This book presents an overview of antimicrobial peptides (AMPs), their mechanisms of antimicrobial action, other activities, and various problems that must still be overcome regarding their clinical application. Divided into four major parts, the book begins with a general overview of AMPs (Part I), and subsequently discusses the various mechanisms of antimicrobial action and methods for researching them (Part 2). It then addresses a range of activities other than antimicrobial action, such as cell penetration, antisepsis, anticancer, and immunomodulatory activities (Part 3), and explores the prospects of clinical application from various standpoints such as the selective toxicity, design, and discovery of AMPs (Part 4). A huge number of AMPs have been discovered in plants, insects, and vertebrates including humans, and constitute host defense systems against invading pathogenic microorganisms. Consequently, many attempts have been made to utilize AMPs as antibiotics. AMPs could help to solve the urgent problem of drug-resistant bacteria, and are also promising with regard to sepsis and cancer therapy. Gathering a wealth of information, this book will be a bible for all those seeking to develop antibiotics, anti-sepsis, or anticancer agents based on AMPs.

This book describes the life, times and science of the Soviet physicist Lev Vasilevich Shubnikov (1901-1937). From 1926 to 1930 Shubnikov worked in Leiden where he was the co-discoverer of the Shubnikov-De Haas effect. After his return to the Soviet Union he founded in Kharkov in Ukraine the first low-temperature laboratory in the Soviet Union, which in a very short time became the foremost physics institute in the country and among other things led to the discovery of type-II superconductivity. In August 1937 Shubnikov, together with many of his colleagues, was arrested and shot early in November 1937. This gripping story gives deep insights into the pioneering work of Soviet physicists before the Second World War, as well as providing much previously unpublished information about their brutal treatment at the hands of the Stalinist regime.

Integrated Nano-Biomechanics provides an integrated look into the rapidly evolving field of nanobiomechanics. The book demystifies the processes in living organisms at the micro- and nano-scale through mechanics, using theoretical, computational and experimental means. The book develops the concept of integrating different technologies along the hierarchical structure of biological systems and clarifies biomechanical interactions among different levels for the analysis of multi-scale pathophysiological phenomena. With a focus on nano-scale processes and biomedical applications, it is shown how knowledge obtained can be utilized in a range of areas, including diagnosis and treatment of various human diseases and alternative energy production. This book is based on collaboration of researchers from a unique combination of fields, including biomechanics, computational mechanics, GPU application, electron microscopy, biology of motile micro-organisms, entomological mechanics and clinical medicine. The book will be of great interest to scientists and researchers involved in disciplines, such as micro- and nano-engineering, bionanotechnology, biomedical engineering, micro- and nano-scale fluid-mechanics (such as in MEMS devices), nanomedicine and microbiology, as well as industries such as optical devices, computer simulation, plant based energy sources and clinical diagnosis of the gastric diseases.

Machine Learning Techniques for Space Weather provides a thorough and accessible presentation of machine learning techniques that can be employed by space weather professionals. Additionally, it presents an overview of real-world applications in space science to the machine learning community, offering a bridge between the fields. As this volume demonstrates, real advances in space weather can be gained using nontraditional approaches that take into account nonlinear and complex dynamics, including information theory, nonlinear auto-regression models, neural networks and clustering algorithms. Offering practical techniques for translating the huge amount of information hidden in data into useful knowledge that allows for better prediction, this book is a unique and important resource for space physicists, space weather professionals and computer scientists in related fields.

Statistical Postprocessing of Ensemble Forecasts brings together chapters contributed by international subject-matter experts describing the current state of the art in the statistical postprocessing of ensemble forecasts. The book illustrates the use of these methods in several important applications including weather, hydrological and climate forecasts, and renewable energy forecasting. After an introductory section on ensemble forecasts and prediction systems, the second section of the book is devoted to exposition of the methods available for statistical postprocessing of ensemble forecasts: univariate and multivariate ensemble postprocessing are first reviewed by Wilks (Chapters 3), then Schefzik and Moeller (Chapter 4), and the more specialized perspective necessary for postprocessing forecasts for extremes is presented by Friederichs, Wahl, and Buschow (Chapter 5). The second section concludes with a discussion of forecast verification methods devised specifically for evaluation of ensemble forecasts (Chapter 6 by Thorarinsdottir and Schuhen). The third section of this book is devoted to applications of ensemble postprocessing. Practical aspects of ensemble postprocessing are first detailed in Chapter 7 (Hamill), including an extended and illustrative case study. Chapters 8 (Hemri), 9 (Pinson and Messner), and 10 (Van Schaeybroeck and Vannitsem) discuss ensemble postprocessing specifically for hydrological applications, postprocessing in support of renewable energy applications, and postprocessing of long-range forecasts from months to decades. Finally, Chapter 11 (Messner) provides a guide to the ensemble-postprocessing software available in the R programming language, which should greatly help readers implement many of the ideas presented in this book. Edited by three experts with strong and complementary expertise in statistical postprocessing of ensemble forecasts, this book assesses the new and rapidly developing field of ensemble forecast postprocessing as an extension of the use of statistical corrections to traditional deterministic forecasts. Statistical Postprocessing of Ensemble Forecasts is an essential resource for researchers, operational practitioners, and students in weather, seasonal, and climate forecasting, as well as users of such forecasts in fields involving renewable energy, conventional energy, hydrology, environmental engineering, and agriculture.

Complexity of Seismic Time Series: Measurement and Application applies the tools of nonlinear dynamics to seismic analysis, allowing for the revelation of new details in micro-seismicity, new perspectives in seismic noise, and new tools for prediction of seismic events. The book summarizes both advances and applications in the field, thus meeting the needs of both fundamental and practical seismology. Merging the needs of the classical field and the very modern terms of complexity science, this book covers theory and its application to advanced nonlinear time series tools to investigate Earth's vibrations, making it a valuable tool for seismologists, hazard managers and engineers.

Indian Shield: Precambrian Evolution and Phanerozoic Reconstitution highlights unique evolutionary trends covering a period of over 3,500 million years, from the oldest crust to the most recent geological activity of the Indian Subcontinent. The book discusses regional terrain geology in terms of the evolutionary history of the crust, describing how the Precambrian Shield evolved from a stable continental region to a tectonically unstable zone marked by frequent high-intensity earthquakes in a Plate-interior setting. It is a complete and readable account of the history of growth and evolution of the Indian Subcontinent, including Bangladesh, Bhutan, India, Nepal and Pakistan. The book is intended for graduate students, researchers, and teachers in the geosciences, especially geophysics, geomorphology and geology. The book also serves as an important resource for tectonics and petrology researchers, as well as those involved in exploration of mineral resources.

This book addresses the mechanism of enrichment of heavy elements in galaxies, a long standing problem in astronomy. It mainly focuses on explaining the origin of heavy elements by performing state-of-the-art, high-resolution hydrodynamic simulations of dwarf galaxies. In this book, the author successfully develops a model of galactic chemodynamical evolution by means of which the neutron star mergers can be used to explain the observed abundance pattern of the heavy elements synthesized by the rapid neutron capture process, such as europium, gold, and uranium in the Local Group dwarf galaxies. The book argues that heavy elements are significant indicators of the evolutionary history of the early galaxies, and presents theoretical findings that open new avenues to understanding the formation and evolution of galaxies based on the abundance of heavy elements in metal-poor stars.

Prior to the 1920s it was generally thought, with a few exceptions, that our galaxy, the Milky Way, was the entire universe. Based on the work of Henrietta Leavitt with Cepheid variables, astronomer Edwin Hubble was able to determine that others had to lie outside our own. This books looks at 60 of those that possess some unusual qualities that make them of particular interest, from supermassive black holes and colliding galaxies to powerful radio sources.

This volume explores how ionic liquids are used in different areas of biotechnology. It also provides insights on the interaction of ionic liquids with biomolecules and biomaterials. Ionic liquids have become essential players in the fields of synthesis, catalysis, extraction and electrochemistry, and their unique properties have opened a wide range of applications in biotechnology. Readers will discover diverse examples of the application of ionic liquids as solvents for biomaterials extraction and pretreatment, in enzymatic and whole cell catalysed reaction, and as activation agents for biocatalysis. Particular attention is given to the biologically functionalized ionic liquids employed in medical and pharmaceutical applications. Although ionic liquids are considered "green solvents", the contributing authors will also explore their environmental impact when applied to biotechnology. Chemical, biological and medical scientists interested in ionic liquids and biotechnology will find this work instructive and informative.

In the field of particle and astrophysics one of the major unresolved problems is to understand the nature and properties of dark matter, which constitutes almost 80% of the matter content of the universe. This book gives a pedagogical introduction to the field of dark matter in general, and in particular to the model building perspective. This book focuses on teaching the basic tools for model building of dark matter, and it aims to motivate the reader to propose a new dark matter model.

This thesis provides new insights into the seemingly anomalous ubiquity of lithium-rich red giant stars. The theory of stellar evolution, one of the most successful models of modern astrophysics, predicts that red giant stars should display negligible levels of lithium (Li) on their surfaces. However, Li-rich giants, defined as those showing more than three times the Li content of the Sun, are found everywhere astronomers look in apparent defiance of established theory. The author addresses this problem, analyzing the different possible explanations for such an anomaly, which include interaction with a binary companion, the production of Li in the interior of the star with its subsequent transport to stellar exteriors, and the stellar interaction with planets. The author focuses on this last possibility, where the Li enrichment may be due to the ingestion of planets or brown dwarfs as the stars in question grew in size while becoming giants. She shows that this process is indeed able to explain an important fraction of giants with Li levels above the three times solar threshold, but that some other mechanism is needed to explain the remaining fraction. While this is an important discovery in its own right, the result that makes this thesis groundbreaking is its demonstration that the threshold between Li-normal and Li-rich is mass dependent rather than a fixed proportion of the Sun's content. This corrects a fundamental misapprehension of the phenomenon and opens up a new framework in which to understand and solve the problem. Finally, the author presents interesting observational applications and samples with which to test this new approach to the problem of Li enrichment in giants.

This thesis describes the design, development, characterisation and clinical translation of three novel devices for optical endoscopic imaging. Over the past decade, rapid innovation in optics and photonics has led to the availability of low-cost and high-performance optical technologies that can be exploited for biomedical applications, but relatively few have been translated into clinic. The work presented outlines for the first time, a comprehensive analysis of the common barriers and unique challenges associated with the translation of optical imaging techniques. To assist developers streamline translation of optical imaging devices in future, a roadmap to clinical translation is outlined, and key translational characteristics are defined. Guided by these, subsequent development of endoscopic devices resulted in preparation and approval of endoscopes for first in human trials in the oesophagus, for early detection of cancer, and in the brain, for delineation of tumour during surgical resection. The thesis culminates in the presentation of results from the first in human use of a compact multispectral endoscope for imaging endogenous tissue contrast in the oesophagus. With continuation of the work as outlined at the end of this thesis, the novel techniques described have the potential to improve the standard of care in their respective indications.

The invention of the semiconductor laser along with silica glass fiber has enabled an incredible revolution in global communication infrastructure of direct benefit to all. Development of devices and system concepts that exploit the same fundamental light-matter interaction continues. Researchers and technologists are pursuing a broad range of emerging applications, everything from automobile collision avoidance to secure quantum key distribution. This book sets out to summarize key aspects of semiconductor laser device physics and principles of laser operation.

This book provides a unified treatment of the characteristics of telescopes of all types, both those whose performance is set by geometrical aberrations and the effect of the atmosphere, and those diffraction-limited telescopes designed for observations from above the atmosphere. The emphasis throughout is on basic principles, such as Fermat's principle, and their application to optical systems specifically designed to image distant celestial sources.
The book also contains thorough discussions of the principles underlying all spectroscopic instrumentation, with special emphasis on grating instruments used with telescopes. An introduction to adaptive optics provides the needed background for further inquiry into this rapidly developing area.

* Geometrical aberration theory based on Fermat's principle
* Diffraction theory and transfer function approach to near-perfect telescopes
* Thorough discussion of 2-mirror telescopes, including misalignments
* Basic principles of spectrometry; grating and echelle instruments
* Schmidt and other catadioptric telescopes
* Principles of adaptive optics
* Over 220 figures and nearly 90 summary tables

Our Universe is amazing. This is its story, told in simple language. The story tells how the Universe came to be what it is today. It starts with the Big Bang and describes how stars, black holes, and our solar system developed. It explores the evolution of life on Earth and investigates the possibility of extra-terrestrial life. It peers into the future and wonders about the Universe's likely old age and death, or whatever else may be its end. The challenge the book takes up is to explain all of this, including some of the astonishing concepts we have in science, such as Einstein's theories of Relativity and Quantum Mechanics, using virtually no mathematics and without dumbing-down. All are described narratively and explained using examples and anecdotes. The book is written for young people with a thirst for learning about the science of space, as well as for 'grown-ups' who want a better understanding of this fascinating subject.