This book describes in detail the various theories on the shape of the Earth from classical antiquity to the present day and examines how measurements of its form and dimensions have evolved throughout this period. The origins of the notion of the sphericity of the Earth are explained, dating back to Eratosthenes and beyond, and detailed attention is paid to the struggle to establish key discoveries as part of the cultural heritage of humanity. In this context, the roles played by the Catholic Church and the philosophers of the Middle Ages are scrutinized. Later contributions by such luminaries as Richer, Newton, Clairaut, Maupertuis, and Delambre are thoroughly reviewed, with exploration of the importance of mathematics in their geodetic enterprises. The culmination of progress in scientific research is the recognition that the reference figure is not a sphere but rather a geoid and that the earth's shape is oblate. Today, satellite geodesy permits the solution of geodetic problems by means of precise measurements. Narrating this fascinating story from the very beginning not only casts light on our emerging understanding of the figure of the Earth but also offers profound insights into the broader evolution of human thought.

This thesis describes the design, development, characterisation and clinical translation of three novel devices for optical endoscopic imaging. Over the past decade, rapid innovation in optics and photonics has led to the availability of low-cost and high-performance optical technologies that can be exploited for biomedical applications, but relatively few have been translated into clinic. The work presented outlines for the first time, a comprehensive analysis of the common barriers and unique challenges associated with the translation of optical imaging techniques. To assist developers streamline translation of optical imaging devices in future, a roadmap to clinical translation is outlined, and key translational characteristics are defined. Guided by these, subsequent development of endoscopic devices resulted in preparation and approval of endoscopes for first in human trials in the oesophagus, for early detection of cancer, and in the brain, for delineation of tumour during surgical resection. The thesis culminates in the presentation of results from the first in human use of a compact multispectral endoscope for imaging endogenous tissue contrast in the oesophagus. With continuation of the work as outlined at the end of this thesis, the novel techniques described have the potential to improve the standard of care in their respective indications.

This book describes the life, times and science of the Soviet physicist Lev Vasilevich Shubnikov (1901-1937). From 1926 to 1930 Shubnikov worked in Leiden where he was the co-discoverer of the Shubnikov-De Haas effect. After his return to the Soviet Union he founded in Kharkov in Ukraine the first low-temperature laboratory in the Soviet Union, which in a very short time became the foremost physics institute in the country and among other things led to the discovery of type-II superconductivity. In August 1937 Shubnikov, together with many of his colleagues, was arrested and shot early in November 1937. This gripping story gives deep insights into the pioneering work of Soviet physicists before the Second World War, as well as providing much previously unpublished information about their brutal treatment at the hands of the Stalinist regime.

This book provides an up-to-date understanding of the progress and current problems of the interplay of nonlocality in the classical theories of gravitation and quantum theory. These problems lie on the border between general relativity and quantum physics, including quantum gravity.

This book provides a general introduction to nanogels, and designs of various stimuli-sensitive nanogels that are able to control drug release in response to specific stimuli. Nanogels are three-dimensional nanosized networks that formed by physically or chemically crosslinking polymers. They have highly interesting properties such as biocompatibility, high stability, particle size adjustment, drug loading capability and modification of the surface for active targeting. They can respond to stimuli which results in the controlled release of drug and targeting of the site.

A conference on "Observational Evidence for Black Holes in the Universe" was held in Calcutta during January 10-17, 1998. This was the first time that experts had gathered to debate and discuss topics such as: Should black holes exist?; If so, how to detect them?; And Have we found them? This book is the essence of this gathering. Black holes are enigmatic objects since it is impossible to locate them through direct observations. State-of-the-art theoretical works and numerical simulations have given us enough clues of what to look for. Observations, from both ground and space-based missions, have been able to find these tell-tale signatures. This book is a compendium of our present knowledge about these theories and observations at the end of the 20th century. Combined, they give an idea of whether black holes, galactic as well as extragalactic, have been detected or not.

This book focuses on the microscopic understanding of the function of organic semiconductors. By tracing the link between their morphological structure and electronic properties across multiple scales, it represents an important advance in this direction. Organic semiconductors are materials at the interface between hard and soft matter: they combine structural variability, processibility and mechanical flexibility with the ability to efficiently transport charge and energy. This unique set of properties makes them a promising class of materials for electronic devices, including organic solar cells and light-emitting diodes. Understanding their function at the microscopic scale - the goal of this work - is a prerequisite for the rational design and optimization of the underlying materials. Based on new multiscale simulation protocols, the book studies the complex interplay between molecular architecture, supramolecular organization and electronic structure in order to reveal why some materials perform well - and why others do not. In particular, by examining the long-range effects that interrelate microscopic states and mesoscopic structure in these materials, the book provides qualitative and quantitative insights into e.g. the charge-generation process, which also serve as a basis for new optimization strategies.

The review papers in this volume provide an in-depth examination of complex astrophysical phenomena of star formation via multi-wavelength observations and modeling. Among the fundamental issues discussed in the book are: The role of gravity and magnetized turbulence in the formation and evolution of molecular clouds The stellar feedback (supernovae, HII regions, winds, cosmic rays) in regulating star formation The origin of the stellar initial mass function and its universality across various environments Jets, magnetic fields and high energy particles in stellar clusters The origin of the first stars and black holes The goal of these papers is to review the major processes governing star formation and to investigate how they are interlinked. In doing so, they provide an in-depth look at the tremendous theoretical and observational progress that has been made in the recent past and also outline future perspectives. Previously published in Space Science Reviews in the Topical Collection "Star Formation"

This book presents the fundamentals and the state of the art of the photophysics of molecular oxygen. The author examines optical transitions between the lowest-lying electronic states in molecular oxygen and how these transitions respond to perturbation, either from an organic molecule or from the plasmon field of a metal nanoparticle. We live on a planet filled with light and oxygen. The interaction between these two components forms the basis of excited state chemistry spanning the fields of synthetic organic chemistry, materials chemistry, molecular biology, and photodynamic treatment of cancer. Still, the fundamental ways in which oxygen is affected by light is an active subject of research and is continually being developed and rationalized. In this book, readers will learn that singlet oxygen, the excited state of oxygen that exhibits unique chemical reactivity, can be selectively made via direct optical excitation of oxygen in a sensitizer-free system. Readers will also discover that this approach can perturb living cells differently depending on the singlet oxygen "dose".

This book focuses on the state-of-the-art of biosensor research and development for specialists and non-specialists. It introduces the fundamentals of the subject with relevant characteristics of transducer elements, as well as biochemical recognition molecules. This book is ideal for researchers of nanotechnology, materials science and biophysics.

This book provides a coherent and comprehensive overview of the generation and application of mono-energetic positron beams. It has been written by acknowledged experts, at a level accessible to graduate students working, or planning to work, with positron beams, and to scientists in other areas who want to know something about the field.

The book begins with a brief historical introduction and an overview of how positron beams are generated and transported. A description of the fate of slow positrons in gaseous and condensed matter, with reference to many of the fundamental measurements made possible by the advent of positron beams, is followed by a discussion on applications in the study of solid surfaces, defect profiling in subsurface regions, interfaces and thin films, and the probing of bulk properties in novel ways. The book ends with a look at the future, considering the prospects for intense positron beams and their potential for further research.

For almost three quarters of a century, the United States has spent billions of dollars and countless person-hours in the pursuit of a national missile defense system that would protect the country from intercontinental ballistic missiles (ICBM) carrying nuclear warheads. The system currently in place consists of 44 long-range antiballistic missiles stationed in Alaska and California to protect the United States from a possible nuclear weapon carrying ICBM attack from North Korea. After all this effort, this systemis still imperfect, being successful only 10 out of 18 tests. This book will provide an historical description of past efforts in national missile defenses to understand the technical difficulties involved. It will also explain how national security concerns, the evolving international environment, and the complexities of US politics have all affected the story. The book will also describe the current systems in place to protect allies and troops in the field from the threat of shorter range missiles. Finally, the book will describe the current US vision for the future of missile defenses and provide some suggestions for alternative paths.

Assuming a background in basic classical physics, multivariable calculus, and differential equations, A Concise Introduction to Quantum Mechanics provides a self-contained presentation of the mathematics and physics of quantum mechanics. The relevant aspects of classical mechanics and electrodynamics are reviewed, and the basic concepts of wave-particle duality are developed as a logical outgrowth of experiments involving blackbody radiation, the photoelectric effect, and electron diffraction. The Copenhagen interpretation of the wave function and its relation to the particle probability density is presented in conjunction with Fourier analysis and its generalization to function spaces. These concepts are combined to analyze the system consisting of a particle confi ned to a box, developing the probabilistic interpretation of observations and their associated expectation values. The Schroedinger equation is then derived by using these results and demanding both Galilean invariance of the probability density and Newtonian energy-momentum relations. The general properties of the Schroedinger equation and its solutions are analyzed, and the theory of observables is developed along with the associated Heisenberg uncertainty principle. Basic applications of wave mechanics are made to free wave packet spreading, barrier penetration, the simple harmonic oscillator, the Hydrogen atom, and an electric charge in a uniform magnetic fi eld. In addition, Dirac notation, elements of Hilbert space theory, operator techniques, and matrix algebra are presented and used to analyze coherent states, the linear potential, two state oscillations, and electron diffraction. Applications are made to photon and electron spin and the addition of angular momentum, and direct product multiparticle states are used to formulate both the Pauli exclusion principle and quantum decoherence. The book concludes with an introduction to the rotation group and the general properties of angular momentum.

This thesis focuses on theoretical analysis of the sophisticated ultrafast optical experiments that probe the crucial first few picoseconds of quantum light harvesting, making an important contribution to quantum biology, an exciting new field at the intersection of condensed matter, physical chemistry and biology. It provides new insights into the role of vibrational dynamics during singlet fission of organic pentacene thin films, and targeting the importance of vibrational dynamics in the design of nanoscale organic light harvesting devices, it also develops a new wavelet analysis technique to probe vibronic dynamics in time-resolved nonlinear optical experiments. Lastly, the thesis explores the theory of how non-linear "breather" vibrations are excited and propagate in the disordered nanostructures of photosynthetic proteins.

This thesis provides new insights into the seemingly anomalous ubiquity of lithium-rich red giant stars. The theory of stellar evolution, one of the most successful models of modern astrophysics, predicts that red giant stars should display negligible levels of lithium (Li) on their surfaces. However, Li-rich giants, defined as those showing more than three times the Li content of the Sun, are found everywhere astronomers look in apparent defiance of established theory. The author addresses this problem, analyzing the different possible explanations for such an anomaly, which include interaction with a binary companion, the production of Li in the interior of the star with its subsequent transport to stellar exteriors, and the stellar interaction with planets. The author focuses on this last possibility, where the Li enrichment may be due to the ingestion of planets or brown dwarfs as the stars in question grew in size while becoming giants. She shows that this process is indeed able to explain an important fraction of giants with Li levels above the three times solar threshold, but that some other mechanism is needed to explain the remaining fraction. While this is an important discovery in its own right, the result that makes this thesis groundbreaking is its demonstration that the threshold between Li-normal and Li-rich is mass dependent rather than a fixed proportion of the Sun's content. This corrects a fundamental misapprehension of the phenomenon and opens up a new framework in which to understand and solve the problem. Finally, the author presents interesting observational applications and samples with which to test this new approach to the problem of Li enrichment in giants.

This book systematically introduces readers to the fundamental physics and a broad range of applications of acoustic levitation, one of the most promising techniques for the container-free handling of small solid particles and liquid droplets. As it does away with the need for solid walls and can easily be incorporated into analysis instruments, acoustic levitation has attracted considerable research interest in many fields, from fluid physics to material science. The book offers a comprehensive overview of acoustic levitation, including the history of acoustic radiation force; the design and development of acoustic levitators; the technology's applications, ranging from drop dynamics studies to bio/chemical analysis; and the insightful perspectives that the technique provides. It also discusses the latest advances in the field, from experiments to numerical simulations. As such, the book provides readers with a clearer understanding of acoustic levitation, while also stimulating new research areas for scientists and engineers in physics, chemistry, biology, medicine and other related fields.

1 Theoretical Background.- 2 Theoretical Calculations on Small Amino Acids.- 3 Gamma-Aminobutyric Acid (GABA).- 4 The Diaminobutyric (DABA), Delta Aminopentanoic, and Epsilon Aminohexanoic Acids.- 5 Ab Initio Studies of Some Acids and Basic Amino Acids: Aspartic, Glutamic, Arginine, and Deaminoarginine.- 6 Proline.- 7 Taurine and Hypotaurine.- 8 Ab Initio Calculations Related to Glucagon.- 9 The Alpha Factor.- 10 Tight Turns in Proteins.- 11 Some Small Peptides.- 12 Oligopeptides That Are Anticancer Drugs.- Appendix Theoretical Studies of a Glucagon Fragment: Ser8-Asp9-Tyr10.

The two years previous to 1997 have produced some of the most exciting results in the history of astronomy: the indirect detection of planets beyond our solar system. The study of the characteristics and physical nature of exo-planets requires an infrared interferometer in space. Such observatory would directly detect the thermal emission from exo-planets and would allow us to see signatures of molecules, such as water, ozone and carbon dioxide, in their atmospheres. The presence of such molecules would be strong evidence for exo-life. In addition, this kind of instrument would help to clarify important questions concerning the birth and death of stars and extragalactic astronomy. In Toledo, scientists and engineers from both sides of the Atlantic met to discuss the technological challenges of an infrared space interferometer and its scientific capabilities, particularly those related to exo-planetary systems and Earth-like planets.

In any linear system, the input and the output are connected by means of a linear operator. When the input can be notionally represented by a function that is null valued everywhere except at a specific location in spacetime, the corresponding output is called the Green function in field theories. Dyadic Green functions are commonplace in electromagnetics, because both the input and the output are vector functions of space and time. This book provides a survey of the state-of-the-art knowledge of infinite space dyadic Green functions.

This book provides information and tools necessary to bridge and integrate the knowledge gaps related to the acquisition and processing of archaeological data, specifically in the field of preventive diagnostics, urban centers, archaeological parks and historical monuments, through activities that involve the application of non-invasive diagnostic detection systems, in the field of applied geophysics. The principal aim of this book is to define a tool for experts that work in the frame of Cultural Heritage and to identify a procedure of intervention transferable and usable in different geographical contexts and areas of investigations: it could help to decide the better technique of investigation to apply in relation to the predictive characteristics of the archaeological site and the objectives of the survey. The book is divided in two parts. The first one explains the theory of ground high resolution penetrating radar (GPR), electrical resistivity tomography (ERT), controlled source electromagnetism system, differential magnetic method and the scenario of integrated methods of different geophysical techniques. Each section covers the basic theory (complete description of the physical parameters involved in the method), field instruments (description of all systems actually offered by commercial companies), field techniques (presentation of the main procedures and setting parameters used to explore the ground surface during data acquisition), techniques of data processing and representation (main processing routines and comparison between different techniques; presentation of different typologies of graphical representation), and the possibility and limitations of methods (explanation of best and worst conditions of implementation of the geophysical technique in relation to the contrasts between archaeological features and the natural background and the features of the instruments and arrays). The second part describes some applications of geophysical prospection to Cultural Heritage in detailed case histories, divided in sections relative to monuments, historical buildings, urban centres, archaeological parks and ancient viability. Moreover, examples of integration of three-dimensional reliefs and geophysical diagnostic of a monuments and studies of large scale reconnaissance implemented into a Geographical Information System are treated. In each case study the authors cover the description of the archaeological or historical contest; an explanation of the problem to solve; a choice of the geophysical methods; the setting of the procedure of data acquisition; techniques of data processing; a representation, interpretation, and discussion of the results.

Crustal Heat Flow: A Guide to Measurement and Modeling is a handbook for geologists and geophysicists who manipulate thermal data, particularly for petroleum exploration. In theory and with practical examples the book discusses the sources of heat within the crust, describes how to maximise the accuracy of temperature data, covers the measurement of the thermal properties of rocks, and explains a number of maturity indicators. The second part covers a range of thermodynamic models of the lithosphere and shows how these can be used to reconstruct the thermal history of individual sedimentary basins. This book will be regarded as a long-term reference source for professionals and researchers. It will also form the basis of advanced undergraduate and graduate student courses in geology, geophysics, engineering, mining, and environmental science, and will be a valuable text for petroleum industry training schemes.

This book explores the dynamics of planetary and stellar fluid layers, including atmospheres, oceans, iron cores, and convective and radiative zones in stars, describing the different theoretical, computational and experimental methods used to study these problems in fluid mechanics, including the advantages and limitations of each method for different problems. This scientific domain is by nature interdisciplinary and multi-method, but while much effort has been devoted to solving open questions within the various fields of mechanics, applied mathematics, physics, earth sciences and astrophysics, and while much progress has been made within each domain using theoretical, numerical and experimental approaches, cross-fertilizations have remained marginal. Going beyond the state of the art, the book provides readers with a global introduction and an up-to-date overview of relevant studies, fully addressing the wide range of disciplines and methods involved. The content builds on the CISM course "Fluid mechanics of planets and stars", held in April 2018, which was part of the research project FLUDYCO, supported by the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program.

Here is an accurate and readable translation of a seminal article by Henri Poincare that is a classic in the study of dynamical systems popularly called chaos theory. In an effort to understand the stability of orbits in the solar system, Poincare applied a Hamiltonian formulation to the equations of planetary motion and studied these differential equations in the limited case of three bodies to arrive at properties of the equations' solutions, such as orbital resonances and horseshoe orbits. Poincare wrote for professional mathematicians and astronomers interested in celestial mechanics and differential equations. Contemporary historians of math or science and researchers in dynamical systems and planetary motion with an interest in the origin or history of their field will find his work fascinating.

This book highlights the current state of the art in single cell analysis, an area that involves many fields of science - from clinical hematology, functional analysis and drug screening, to platelet and microparticle analysis, marine biology and fundamental cancer research. This book brings together an eclectic group of current applications, all of which have a significant impact on our current state of knowledge. The authors of these chapters are all pioneering researchers in the field of single cell analysis. The book will not only appeal to those readers more focused on clinical applications, but also those interested in highly technical aspects of the technologies. All of the technologies identified utilize unique applications of photon detection systems.