This second edition of Medical Biochemistry is supported by more than 45 years of teaching experience, providing coverage of basic biochemical topics, including the structural, physical, and chemical properties of water, carbohydrates, lipids, proteins, and nucleic acids. In addition, the general aspects of thermodynamics, enzymes, bioenergetics, and metabolism are presented in straightforward and easy-to-comprehend language. This book ties these concepts into more complex aspects of biochemistry using a systems approach, dedicating chapters to the integral study of biological phenomena, including cell membrane structure and function, gene expression and regulation, protein synthesis and post-translational modifications, metabolism in specific organs and tissues, autophagy, cell receptors, signal transduction pathways, biochemical bases of endocrinology, immunity, vitamins and minerals, and hemostasis. The field of biochemistry is continuing to grow at a fast pace. This edition has been revised and expanded with all-new sections on the cell plasma membrane, the human microbiome, autophagy, noncoding, small and long RNAs, epigenetics, genetic diseases, virology and vaccines, cell signaling, and different modes of programmed cell death. The book has also been updated with full-color figures, new tables, chapter summaries, and further medical examples to improve learning and better illustrate the concepts described and their clinical significance.

Today, air-to-surface vessel (ASV) radars, or more generally airborne maritime surveillance radars, are installed on maritime reconnaissance aircraft for long-range detection, tracking and classification of surface ships (ASuW--anti-surface warfare) and for hunting submarines (ASW--anti-submarine warfare). Such radars were first developed in the UK during WWII as part of the response to the threat to shipping from German U boats. This book describes the ASV radars developed in the UK and used by RAF Coastal Command during WWII for long-range maritime surveillance.

Renewable energy (RE) is a subject of great interest today. It is one of the two main means for implementing climate change mitigation programmes, and presently the only perceived means for replacing the declining global fossil fuel reserves. It also helps fight poverty and assists in the global quest for gender equity by taking clean energy where it is needed most for development. It is perhaps not surprising therefore that there is so much coverage of RE in both the conventional media and the internet by media and tech writers, economists and bloggers, many of who only have a partial understanding of the technology itself. The end result is mostly promotional rhetoric that says little about the true value of the technology, and leads to a confused picture for the serious individual or decision-maker who wants to know what the technology is really capable of doing. This book provides a clear and factual picture of the status of RE and its capabilities today. The need for such a book was first realized by the author when he was engaged in a renewable energy capacity-building project encompassing countries from Europe, the Caribbean, Africa, and the Pacific. The book is largely non-technical in nature; it does however contain enough mention of the science and technology to enable readers to go further with their own investigations should they wish to. The book covers all areas of renewable energy (RE), starting from biomass energy and hydropower and proceeding to wind, solar and geothermal energy before ending with an overview of ocean energy. It begins with a simple introduction to the physical principles of the RE technologies, followed by an enumeration of the requirements for their successful implementation. The last two chapters consider how the technologies are actually being implemented today and their roles in climate change mitigation and poverty alleviation.

Cosmology is the study of the origin, size, and evolution of the entire universe. Every culture has developed a cosmology, whether it be based on religious, philosophical, or scientific principles. In this book, the evolution of the scientific understanding of the Universe in Western tradition is traced from the early Greek philosophers to the most modern 21st century view. After a brief introduction to the concept of the scientific method, the first part of the book describes the way in which detailed observations of the Universe, first with the naked eye and later with increasingly complex modern instruments, ultimately led to the development of the "Big Bang" theory. The second part of the book traces the evolution of the Big Bang including the very recent observation that the expansion of the Universe is itself accelerating with time.

Since the earliest days of human existence, the clash of thunder and trembling of the hills has struck fear into the hearts of seasoned warriors and tribal villagers alike. Great gods, demi-gods, and heroes were created to explain the awesome, mysterious, and incomprehensibly powerful forces of Nature in a feeble attempt to make sense of the world around them. To our advanced scientific minds today, these explanations seem childish and ridiculous; however, the power to flatten thousands of square miles of ancient forest, create massive holes in the Earth itself, and cause mountains to tremble to their very roots are more than enough reason to believe. Indeed, perhaps our scientific advancement has caused us to not fully or completely appreciate the awesome scale and power that Nature can wield against us. The study of shock wave formation and dynamics begins with a study of waves themselves. Simple harmonic motion is used to analyze the physical mechanisms of wave generation and propagation, and the principle of superposition is used to mathematically generate constructive and destructive interference. Further development leads to the shock singularity where a single wave of immense magnitude propagates and decays through various media. Correlations with the fields of thermodynamics, meteorology, crater formation, and acoustics are made, as well as a few special applications. Direct correlation is made to events in Arizona, Siberia, and others. The mathematical requirement for this text includes trigonometry, differential equations, and large series summations, which should be accessible to most beginning and advanced university students. This text should serve well as supplementary material in a course covering discrete wave dynamics, applied thermodynamics, or extreme acoustics.

All matter, including galaxy clusters, galaxies, and their constituents follow orbits and flows driven by the net attraction of near and distant masses. The book presents the development of studies of peculiar motions along with discoveries in large-scale structure, the cosmic microwave background, baryonic oscillations, gravity waves, and their relation to current work on gravitation and dark matter.The results of peculiar motion measurements in the late 20th century are described as they were used to search for the dipole of the galaxy motions, a determination of cosmic density, and to compare with the cosmic microwave dipole, which led to the discovery of galactic flows and the Great Attractor. Newer detailed measurements from surveys in the 21st century have helped resolve the nature of these structures. Some prospects for future investigations are discussed.

Principles of Nucleic Acid Structure, Second Edition, provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussions of X-ray crystallography, NMR, molecular modelling and databases. The book's focus is on a survey of structures that are especially important for biomedical research and pharmacological applications. This updated edition includes the latest advances relevant to recognition of DNA and RNA by small molecules and proteins, including sections on RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes and short interfering RNA (siRNA). This reference is a must-have for those seeking an authoritative, comprehensive and up-to-date source on all aspects of nucleic acid structure, from basic first principles to details of recent research results.

Visual Astronomy introduces the basics of observational astronomy, a fundamentally limitless opportunity to learn about the universe with your unaided eyes or with tools such as binoculars, telescopes, or cameras.

This book is based on a set of 18 class-tested lectures delivered to fourth-year physics undergraduates at Grifi th University in Brisbane, and the book presents new discoveries by the Nobel-prize winning LIGO collaboration. The author begins with a review of special relativity and tensors and then develops the basic elements of general relativity (a beautiful theory that unifies special relativity and gravitation via geometry) with applications to the gravitational deflection of light, global positioning systems, black holes, gravitational waves, and cosmology. The book provides readers with a solid understanding of the underlying physical concepts; an ability to appreciate and in many cases derive important applications of the theory; and a solid grounding for those wishing to pursue their studies further. General Relativity: An Introduction to Black Holes, Gravitational Waves, and Cosmology also connects general relativity with broader topics. There is no doubt that general relativity is an active and exciting field of physics, and this book successfully transmits that excitement to readers.

This introduction to quantum field theory (QFT) is written by a physical chemist for physical chemists, chemical physicists, and other non-physicists with knowledge of quantum theory but who want to explore ways in which they might use the power of QFT in their investigations. This book starts where many graduate courses in quantum theory that are offered to chemistry students leave off and first develops some of the necessary tools, such as Fock algebra, which is applied to solving the quantum oscillator problem. Then it is used to develop the theory of coherent states, time-dependent perturbation theory, and the treatment of bosons and fermions. With this background, the QFT of a perfect gas is derived and a connection to thermodynamics is demonstrated. Application to imperfect gases provides a new approach to modelling gas-liquid phase transitions. The book concludes with photons and their interaction with molecular ensembles, and brings us to full circle by deriving the blackbody radiation law, which started it all. The power of the QFT methodology and the breadth of its applications should fascinate the reader as it has the author.

All living matter is comprised of cells, small compartments isolated from the environment by a cell membrane and filled with concentrated solutions of various organic and inorganic compounds. Some organisms are single-cell, where all life functions are performed by that cell. Others have groups of cells, or organs, specializing in one particular function. The survival of the entire organism depends on all of its cells and organs fulfilling their roles. While the cells are studied by different sciences, they are seen differently by biologists, chemists, or physicists. Biologists concentrate their attention on cell structure and function. What the cells consists of? Where are its organelles? What function each organelle fulfils? From a chemists' point of view, a cell is a complex chemical reaction chamber where various molecules are synthesized or degraded. The main question is how these, sometimes very complicated chains of reactions are controlled. Finally, from a physics standpoint, some of the fundamental questions are about the physical movement of all these molecules between organelles within the cell, their exchange with the extracellular medium, as well as electrical phenomena resulting from such transport. The aim of this book is to look into the basic physical phenomena occurring in cells. These physical transport processes facilitate chemical reactions in the cell and various electrical effects, and that in turn leads to biological functions necessary for the cell to satisfy its role in the mother organism. Ultimately, the goals of every cell are to stay alive and to fulfill its function as a part of a larger organ or organism. The first volume of this book is an inventory of physical transport processes occurring in cells while this second volume provides a closer look at how complex biological and physiological cell phenomena result from these very basic physical processes.

Biochemistry of Lipids, Lipoproteins and Membranes, Seventh Edition serves as a comprehensive, general reference book for scientists and students studying lipids, lipoproteins and membranes. Here, across 19 chapters, leaders in the field summarize fundamental concepts, recent research developments, data analysis, and implications for human disease and intervention. Topics discussed include lipid biology in both prokaryotes and eukaryotes, fatty acid synthesis, desaturation and elongation, and pathways leading to synthesis of complex phospholipids, sphingolipids and their structural variants. Chapters also examine how bioactive lipids are involved in cell signaling, with an emphasis on disease implications and pathological consequences. As the field advances, each chapter in this new edition has been fully revised to address emerging topics, with all-new coverage of lipid droplets and their role as regulatory organelles for energy homeostasis, as well as their relationship to obesity, liver disease and diabetes. Evolving research in fatty acid handling and storage in eukaryotes is also discussed in-depth, with new sections addressing fatty acid uptake, activation and lipolysis.

For the past decade or more, much of cell biology research has been focused on determining the key molecules involved in different cellular processes, an analytical problem that has been amenable to biochemical and genetic approaches. Now, we face an integrative problem of understanding how all of these molecules work together to produce living cells, a challenge that requires using quantitative approaches to model the complex interactions within a cell, and testing those models with careful quantitative measurements. This book is an introductory overview of the various approaches, methods, techniques, and models employed in quantitative cell biology, which are reviewed in greater detail in the other volumes in this e-book series. Particular emphasis is placed on the goals and purpose of quantitative analysis and modeling, and the special challenges that cell biology holds for understanding life at the physical level.

Structure and Evolution of Single Stars: An introduction is intended for upper-level undergraduates and beginning graduates with a background in physics. Following a brief overview of the background observational material, the basic equations describing the structure and evolution of single stars are derived. The relevant physical processes, which include the equation of state, opacity, nuclear reactions and neutrino losses are then reviewed. Subsequent chapters describe the evolution of low-mass stars from formation to the final white dwarf phase. The final chapter deals with the evolution of massive stars.

This is an in-depth look at baryon number violation in the Standard Model including the necessary background in finite temperature field theory, plasma dynamics and how to calculate the out of equilibrium evolution of particle number densities throughout a phase transition. It is a self-contained pedagogical review of the theoretical background to electroweak baryogenesis as well as a summary of the other prevailing mechanisms for producing the asymmetry between matter and antimatter using the Minimal Supersymmetric Standard Model as a pedagogical tool whenever appropriate.

Electric glow discharges (glows) can be found almost everywhere, from atmospheric electricity to modern plasma technologies, and have long been the object of research. The main purpose of this book is to provide simple illustrations of the basic physical mechanisms and principles that determine the properties of electric glow discharges. It should enable readers to successfully participate in scientific and technical progress.