Gene therapy as a potential method for treatment of genetic disorders and other malignancies as well as treatment of many cancers has attracted a great amount of attention in recent years. Current research focuses on stable and smart drug/gene delivery systems, including controlled release. Smart nanostructures have been considered as a promising approach when applied to drug and gene delivery systems, and could solve the problems related to the inefficient transfer of medication to the affected cells.

Protein assay methods are used for protein identification with blood groups, cell surface markers, drugs and toxins. This text features comprehensive protocols essential for researchers studying various areas of biological and medical sciences. The techniques in this text are presented in a friendly step-by-step fashion, providing useful tips and potential pitfalls while enabling researchers at all stages to embark on basic problems using a vareity of technologies and model systems.
Focus on protein identification using mass spectrometryStep-by-step procedures detailing materials, procedures, comment and pitfallsInformation on the plethora of technologies needed to tackle complex problems

Magnetic methods are widely used in exploration, engineering, borehole and global geophysics, and the subjects of this book are the physical and mathematical principles of these methods regardless of the area of application.
Beginning with Ampere's law, the force of interaction between currents is analyzed, and then the concept of the magnetic field is introduced and the fundamental features are discussed.
Special attention is paid to measurements of relaxation processes, including topics as the spin echoes or refocusing. Also the special role of the magnetic method in the development of the plate tectonic theory is described.
* covers all the physical and mathematical principles of magnetic methods regardless of the area of application.
* presents thorough developments of magnetic methods.

"Advances in Imaging and Electron Physics" merges two long-running serials--"Advances in Electronics and Electron Physics" and "Advances in Optical and Electron Microscopy." This series features extended articles on the physics of electron devices (especially semiconductor devices), particle optics at high and low energies, microlithography, image science and digital image processing, electromagnetic wave propagation, electron microscopy, and the computing methods used in all these domains.
* Updated with contributions from leading international scholars and industry experts
* Discusses hot topic areas and presents current and future research trends
* Invaluable reference and guide for physicists, engineers and mathematicians

"Venus has always been associated with the feminine in astrology and in culture, yet little emphasis is placed upon the wisdom aspect of the planet. With the cycles of Venus we are given insight into the unfolding of wisdom within ourselves and society, especially with the cycle of Venus' inferior conjunctions - the so-called 2nd order cycle of the planet. In her timely and much-needed work, Firegazing, Gail has brilliantly outlined the meaning and import of these cycles and the deeper meaning of a planet that often only receives a passing notice in astrology, yet is so intimately connected with our own lives and what it is to be human. When Venus passes across the face of the solar orb, we are given opportunity to gaze into the very fire of the soul itself. Well done, Gail " - Malvin Artley

With over 150 alphabetically arranged entries about key scientists, concepts, discoveries, technological innovations, and learned institutions, the Oxford Guide to Physics and Astronomy traces the history of physics and astronomy from the Renaissance to the present. For students, teachers, historians, scientists, and readers of popular science books such as Galileo's Daughter, this guide deciphers the methods and philosophies of physics and astronomy as well as the historical periods from which they emerged. Meant to serve the lay reader and the professional alike, this book can be turned to for the answer to how scientists learned to measure the speed of light, or consulted for neat, careful summaries of topics as complicated as quantum field theory and as vast as the universe.
The entries, each written by a noted scholar and edited by J. L. Heilbron, Professor of History and Vice Chancellor, Emeritus, University of California, Berkeley, reflect the most up-to-date research and discuss the applications of the scientific disciplines to the wider world of religion, law, war, art and literature. No other source on these two branches of science is as informative or as inviting. Thoroughly cross-referenced and accented by dozens of black and white illustrations, the Oxford Guide to Physics and Astronomy is the source to turn to for anyone looking for a quick explanation of alchemy, x-rays and any type of matter or energy in between.

This book reports on the extraordinary observation of TeV gamma rays from the Crab Pulsar, the most energetic light ever detected from this type of object. It presents detailed information on the painstaking analysis of the unprecedentedly large dataset from the MAGIC telescopes, and comprehensively discusses the implications of pulsed TeV gamma rays for state-of-the-art pulsar emission models. Using these results, the book subsequently explores new testing methodologies for Lorentz Invariance Violation, in terms of a wavelength-dependent speed of light. The book also covers an updated search for Very-High-Energy (VHE), >100 GeV, emissions from millisecond pulsars using the Large Area Telescope on board the Fermi satellite, as well as a study on the promising Pulsar Wind Nebula candidate PSR J0631. The observation of VHE gamma rays is essential to studying the non-thermal sources of radiation in our Universe. Rotating neutron stars, also known as pulsars, are an extreme source class known to emit VHE gamma rays. However, to date only two pulsars have been detected with emissions above 100 GeV, and our understanding of their emission mechanism is still lacking.

This book treats essentials from neurophysiology (Hodgkin-Huxley equations, synaptic transmission, prototype networks of neurons) and related mathematical concepts (dimensionality reductions, equilibria, bifurcations, limit cycles and phase plane analysis). This is subsequently applied in a clinical context, focusing on EEG generation, ischaemia, epilepsy and neurostimulation. The book is based on a graduate course taught by clinicians and mathematicians at the Institute of Technical Medicine at the University of Twente. Throughout the text, the author presents examples of neurological disorders in relation to applied mathematics to assist in disclosing various fundamental properties of the clinical reality at hand. Exercises are provided at the end of each chapter; answers are included. Basic knowledge of calculus, linear algebra, differential equations and familiarity with MATLAB or Python is assumed. Also, students should have some understanding of essentials of (clinical) neurophysiology, although most concepts are summarized in the first chapters. The audience includes advanced undergraduate or graduate students in Biomedical Engineering, Technical Medicine and Biology. Applied mathematicians may find pleasure in learning about the neurophysiology and clinic essentials applications. In addition, clinicians with an interest in dynamics of neural networks may find this book useful, too.

Have you ever seen a comet? It is a marvelous experience, one that all humans can share, that spawns a deep yearning to understand the spectacle. Have you ever wondered what comets are and why astronomers spend so much time studying them? Now, a comet expert and an astronomical historian have come together to produce the unique book that you now hold in your hands. Using their several decades of teaching experience, the authors have concisely presented the information you need to comprehend these majestic apparitions that grace our night skies. No mathematical proficiency is needed, in fact, this book doesn't contain a single equation! Comets are cosmic Rosetta stones, bridging our current knowledge by digging back to the earliest days of our Solar Systems. How did life arise on Earth? Did comets play a significant role in bringing water and the necessary organic matter to our early Earth? How about the dinosaurs? Were they driven to extinction by a cometary impact 66 million years ago? Comets may be both the enablers and destroyers of life on Earth as we know it. These are some of the tantalizing questions discussed here. If you so desire, steps are given to join the ranks of amateur comet hunters. Astronomy is one of the last sciences where amateurs play a significant role. Your reward for discovery? A comet officially bearing your name in the history books! The next Great Comet is on its way, we just do not know when it will arrive. Armed with this book, you will be ready to enjoy this unforgettable event.

For some time immunotherapy has been heralded as a breakthrough approach for cancer treatment. Although the potential of this strategy remains solid, the approach needs considerable refinement. Whilst some programmes are looking to increase the understanding of molecular and cellular mechanisms underlying the stimulation of antitumor immunity, others are trying to find the most appropriate clinical setting that will reveal the role of the immune system in combating cancer. Among the most important discoveries have been tumor-specific antigens.
This thematic volume highlights some key issues and discusses where they may move forward. It has been put together by two leading cancer immunotherapists from two eminent institutions that focus on cancer research.

This is an overview of single molecule physics, the study of both equilibrium and non-equilibrium properties at the single molecule level. It begins with an introduction to this fascinating science and includes a chapter on how to build the most popular instrument for single molecule biophysics, the total internal reflection fluorescence (TIRF) microscope. It concludes with the Poisson process approach to statistical mechanics, explaining how to relate the process to diverse areas and see how data analysis and error bars are integral parts of science.

This volume is a self-contained companion piece to Studying Vibrational Communication, published in 2014 within the same series. The field has expanded considerably since then, and has even acquired a name of its own: biotremology. In this context, the book reports on new concepts in this fascinating discipline, and features chapters on state-of-the art methods for studying behavior tied to substrate-borne vibrations, as well as an entire section on applied biotremology. Also included are a historical contribution by pioneers in the field and several chapters reviewing the advances that have been made regarding specific animal taxa. Other new topics covered are vibrational communication in vertebrates, multimodal communication, and biotremology in the classroom, as well as in art and music. Given its scope, the book will appeal to all those interested in communication and vibrational behavior, but also to those seeking to learn about an ancient mode of communication.

GPCRS: Structure, Function, and Drug Discovery provides a comprehensive overview of recent discoveries and our current understanding of GPCR structure, signaling, physiology, pharmacology and methods of study. In addition to the fundamental aspects of GPCR function and dynamics, international experts discuss crystal structures, GPCR complexes with partner proteins, GPCR allosteric modulation, biased signaling through protein partners, deorphanization of GPCRs, and novel GPCR-targeting ligands that could lead to the development of new therapeutics against human diseases. GPCR association with, and possible therapeutic pathways for, retinal degenerative diseases, Alzheimer's disease, Parkinson's disease, cancer and diabetic nephropathy, among other illnesses, are examined in-depth.

This book is an introduction to the mechanical properties, the force generating capacity, and the sensitivity to mechanical cues of the biological system. To understand how these qualities govern many essential biological processes, we also discuss how to measure them. However, before delving into the details and the techniques, we will first learn the operational definitions in mechanics, such as force, stress, elasticity, viscosity and so on. This book will explore the mechanics at three different length scales--molecular, cellular, and tissue levels--sequentially, and discuss the measurement techniques to quantify the intrinsic mechanical properties, force generating capacity, mechanoresponsive processes in the biological systems, and rupture forces.

Published by the American Geophysical Union as part of the Geophysical Monograph Series, Volume 138.Subduction zones helped nucleate and grow the continents, they fertilize and lubricate the earth's interior, they are the site of most subaerial volcanism and many major earthquakes, and they yield a large fraction of the earth's precious metals. They are obvious targets for study--almost anything you learn is likely to impact important problems--yet arriving at a general understanding is notoriously difficult: Each subduction zone is distinct, differing in some important aspect from other subduction zones; fundamental aspects of their mechanics and igneous processes differ from those in other, relatively well-understood parts of the earth; and there are few direct samples of some of their most important metamorphic and metasomatic processes. As a result, even first-order features of subduction zones have generated conflict and apparent paradox. A central question about convergent margins, for instance--how vigorous magmatism can occur where plates sink and the mantle cools--has a host of mutually inconsistent answers: Early suggestions that magmatism resulted from melting subducted crust have been emphatically disproved and recently just as emphatically revived; the idea that melting is fluxed by fluid released from subducted crust is widely held but cannot explain the temperatures and volatile contents of many arc magmas; generations of kinematic and dynamic models have told us the mantle sinks at convergent margins, yet strong evidence suggests that melting there is often driven by upwelling. In contrast, our understanding ofwhy volcanoes appear at ocean ridges and "hotspots"--although still presenting their own chestnuts--are fundamentally solved problems.

NASA SP-4113. The NASA History Series. Provides a biography of Dr. William H. Pickering. The dust jacket states: "More than any other individual Bill Pickering was responsible for America's success in exploring the planets, an endeavor that demanded vision, courage, dedication, expertise, and the ability to inspire two generations of scientists and engineers at the Jet Propulsion Laboratory," a quote from Thomas P. Everhart.