This book introduces readers to MesoBioNano (MBN) Explorer - a multi-purpose software package designed to model molecular systems at various levels of size and complexity. In addition, it presents a specially designed multi-task toolkit and interface - the MBN Studio - which enables the set-up of input files, controls the simulations, and supports the subsequent visualization and analysis of the results obtained. The book subsequently provides a systematic description of the capabilities of this universal and powerful software package within the framework of computational molecular science, and guides readers through its applications in numerous areas of research in bio- and chemical physics and material science - ranging from the nano- to the mesoscale. MBN Explorer is particularly suited to computing the system's energy, to optimizing molecular structure, and to exploring the various facets of molecular and random walk dynamics. The package allows the use of a broad variety of interatomic potentials and can, e.g., be configured to select any subset of a molecular system as rigid fragments, whenever a significant reduction in the number of dynamical degrees of freedom is required for computational practicalities. MBN Studio enables users to easily construct initial geometries for the molecular, liquid, crystalline, gaseous and hybrid systems that serve as input for the subsequent simulations of their physical and chemical properties using MBN Explorer. Despite its universality, the computational efficiency of MBN Explorer is comparable to that of other, more specialized software packages, making it a viable multi-purpose alternative for the computational modeling of complex molecular systems. A number of detailed case studies presented in the second part of this book demonstrate MBN Explorer's usefulness and efficiency in the fields of atomic clusters and nanoparticles, biomolecular systems, nanostructured materials, composite materials and hybrid systems, crystals, liquids and gases, as well as in providing modeling support for novel and emerging technologies. Last but not least, with the release of the 3rd edition of MBN Explorer in spring 2017, a free trial version will be available from the MBN Research Center website (mbnresearch.com).

This book lays the foundations of gas- and fluid dynamics.The basic equations are developed from first principles, building on the (assumed) knowledge of Classical Mechanics. This leads to the discussion of the mathematical properties of flows, conservation laws, perturbation analysis, waves and shocks. Most of the discussion centers on ideal (frictionless) fluids and gases. Viscous flows are discussed when considering flows around obstacles and shocks. Many of the examples used to illustrate various processes come from astrophysics and geophysical phenomena.

This book provides detailed calculated values for the thermal radiative and thermodynamic functions of black-body radiation in finite spectral ranges. The results are presented in tabular form. The areas of thermal power generation, infrared medical diagnostics, solar power and nuclear generation, and astrophysics are included. A range of the thermal radiative and thermodynamic functions are calculated by the authors in the finite frequency/wavenumber/wavelength intervals at different temperatures. This book also contains the tables of the chromaticity coordinates and RGB parameters calculated for different color spaces (Rec.709 (HDTV), sRGB, Adobe RGB). A number of the optimization problems is formulated and solved for various thermal black-body radiative and thermodynamic functions in a finite range of frequencies.

Cosmical Aerodynamics - Why was it so Difficult?.- Shaping Planetary Nebulae.- Investigating the Kinematics of the Faint Giant Haloes of Planetary Nebulae.- Shock Modelling of Planetary Nebulae.- Imaging Polarimetry of Proto-Planetary Nebulae.- IRAS 17423-1755: a BQ[ ] Star with a Variable Velocity Outflow.- Spectroscopic Constraints on Outflows from BN-type Objects.- First Wavelet Analysis of Emission Line Variations in Wolf-Rayet Stars-Turbulence in Hot-Star Outflows.- Complex Structure Associated with the Wolf-Rayet Star WR147.- The Importance of Continuum Radiation for the Stellar Wind Hydrodynamics of Hot Stars.- Herbig Ae/Be Stars.- 3-D Radiative Line Transfer for Be Star Envelopes.- Radiatively Driven Winds Using Lagrangian Hydrodynamics.- Parametric Determination of the Inclination of Keplerian Circumstellar Discs from Spectropolarimetric Profiles of Scattered Lines.- Observational Evidence for Global Oscillations in Be Star Disks.- Coupled Stellar Jet/Molecular Outflow Models.- Modelling Jet-Driven Molecular Outflows.- Jets.- A Simulation of a Jet with the Hiccups.- Interactions Between Molecular Outflows and Optical Jets.- Proper Motion Measurements in the HH 46/47 Outflow.- The Serpens Radio Jet: Evidence of Precession or Nutation.- Fragmentation and Heating of Streamers in Orion.- Highly Supersonic Molecular Flows in Wind-Clump Boundary Layers.- High Density Tracers in Outflow Regions: NH3 vs. CS.- Modelling the Constancy of X.- Gas-Grain Interaction in the Low Mass Star-Forming Region B335.- The Structure and Dynamics of M17SW.- The Hydrodynamics of Bipolar Explosions.- Shock-Heated Gas in the Outbursts of Classical Novae.- The Crab Nebula Revisited.- Pulsar Magnetospheres: Classical and Quasi-Classical Descriptions.- The Global Structure of the Insterstellar Medium.- A Power Spectrum Description of Galactic Neutral Hydrogen.- A Statistical Description of Astrophysical Turbulence.- Rosat Wide Field Camera Data and the Temperature of the Interstellar Medium.- Hierarchial Galactic Dynamo and Seed Magnetic Field Problem.- Cosmic Ray Diffusion at Energies of 1 MeV to 105 GeV.- Alfvenic Waves and Alignment of Large Grains.- An Interstellar Thermostat: Gas Temperature Regulated by Grain Charge.- Recent Optical Observations of Circumstellar and Interstellar Phenomena.- Internal Motions of HII Regions and Giant HII Regions.- High-Speed Flows in the Vicinity of the Trapezium Stars.- The Orion Nebula: Structure, Dynamics, and Population.- An Evolutionary Model for the Wolf Rayet Nebula NGC 2539.- Supersonic Turbulence in Giant Extragalactic HII Regions.- The Dynamics of the Ring Nebula Surrounding the LBV Candidate He 3-519.- Turbulent Mixing in Wind-Blown HII Regions.- Shock Wave Structure in the Cygnus Loop.- Catastrophic Cooling Diagnostics.- Star Formation in Shocked Layers.- Binary and Multiple Star Formation.- Galactic Fountains.- The Solution Topology of Galactic Winds.- Galactic Scale Gas Flows in Colliding Galaxies: 3-Dimensional, N-Body/Hydrodynamics Experiments.- Gas Flow in a Two Component Galactic Disk.- How Faithful Are N-Body Simulations of Disc Galaxies? - Artificial Suppression of Gaseous Dynamical Instabilities.- Long-Lived Spiral Structure in N-Body Simulations: Work in Progress.- The Use of Gravitational Microlensing to Scan the Structure of BAL QSOs.- Anomalous Component Motion in the MAS Double Radio Source 0646+600.- Effects of Dense Medium Surrounding Galactic-Sized Radio Sources.- 8.4 Ghz Vla Observations of the CfA Seyfert Sample.- Relativistic Jet Simulations.- Active Galactic Nuclei Flow Velocities and the Highest Energy Cosmic Rays.- Hidden Broad Line Regions and Anisotropy in AGN.- The Starburst Galaxy NGC1808: Another M82?.- List of Forthcoming Papers.- The 'KLUWER' LaTeX Style File.

In his PhD dissertation Martin Bo Nielsen performs observational studies of rotation in stars like the Sun. The interior rotation in stars is thought to be one of the driving mechanisms of stellar magnetic activity, but until now this mechanism was unconstrained by observational data. NASA's Kepler space mission provides high-precision observations of Sun-like stars which allow rotation to be inferred using two independent methods: asteroseismology measures the rotation of the stellar interior, while the brightness variability caused by features on the stellar surface trace the rotation of its outermost layers. By combining these two techniques Martin Bo Nielsen was able to place upper limits on the variation of rotation with depth in five Sun-like stars. These results suggest that the interior of other Sun-like stars also rotate in much the same way as our own Sun.

This book focuses on the mechanobiological principles in tissue engineering with a particular emphasis on the multiscale aspects of the translation of mechanical forces from bioreactors down to the cellular level. The book contributes to a better understanding of the design and use of bioreactors for tissue engineering and the use of mechanical loading to optimize in vitro cell culture conditions. It covers experimental and computational approaches and the combination of both to show the benefits that computational modelling can bring to experimentalists when studying in vitro cell culture within a scaffold. With topics from multidisciplinary fields of the life sciences, medicine, and engineering, this work provides a novel approach to the use of engineering tools for the optimization of biological processes and its application to regenerative medicine. The volume is a valuable resource for researchers and graduate students studying mechanobiology and tissue engineering. For undergraduate students it also provides deep insight into tissue engineering and its use in the design of bioreactors. The book is supplemented with extensive references for all chapters to help the reader to progress through the study of each topic.

This book describes the discovery of the stratosphere itself and of various unexpected phenomena in the stratosphere: e.g., a manned balloon flight in 1901 as high as 11 km; an expedition to Lake Victoria in Africa in 1908 which found inexplicable west winds in the stratosphere above the equator; and the discovery of the ozone layer in the 1930s, the Berlin Phenomenon in 1952, the Quasi-Biennial Oscillation in 1960, the influence of volcanic eruptions in 1970, the ozone hole in 1984, and the influence of the 11-year solar cycle in 1987. The book also describes how these phenomena are connected with each other and how they create variability in the climate system, in addition to man-made changes, such as the decrease in ozone. We use the stratosphere as one example of Nature's complexity and of how often discoveries are ignored because they do not fit prevalent concepts.

Freeze-drying, in the past popular in the food industry, has more recently been adopted by the pharmaceutical industry as a standard method for the production of stable solid preparations. Freeze-drying of Pharmaceuticals and Biopharmaceuticals is the first book to specifically describe this process, as related to the pharmaceutical industry. The emphasis of this book is on the properties of the materials processed, how effective formulations are arrived at, and how they are stored and marketed. Beginning with a historical overview of the process, Freeze-drying of Pharmaceuticals and Biopharmaceuticals briefly describes the processes and equipment involved, including: the physics, chemistry and biochemistry associated with freezing, aspects of formulation development, primary and secondary drying; the economics and engineering of scaling up; and, most importantly, attributes of the dried product. It also discusses in detail the science behind freeze-drying, such as the properties of crystalline and amorphous solids. The book concludes with selected case studies and discusses the future of freeze-drying, advances in alternative drying methods, and concludes with an extensive bibliography. This book, written by a leading expert in the field, is aimed primarily at product and process developers in the biopharmaceutical industry and academia.

This thesis describes the application of a Monte Carlo radiative transfer code to accretion disc winds in two types of systems spanning 9 orders of magnitude in mass and size. In both cases, the results provide important new insights. On small scales, the presence of disc winds in accreting white dwarf binary systems has long been inferred from the presence of ultraviolet absorption lines. Here, the thesis shows that the same winds can also produce optical emission lines and a recombination continuum. On large scales, the thesis constructs a simple model of disc winds in quasars that is capable of explaining both the observed absorption and emission signatures - a crucial advance that supports a disc-wind based unification scenario for quasars. Lastly, the thesis also includes a theoretical investigation into the equivalent width distribution of the emission lines in quasars, which reveals a major challenge to all unification scenarios.

This book talks about photoplethysmography (PPG) techniques based on computer-aided data processing. In particular, it presents the results of a co-operative Indo-German project on the topic between Indian Institute of Technology at Chennai and RWTH Aachen University. Measuring system design, experimental details and some preliminary results obtained so far within the framework of this project are presented here. From the investigations carried out so far using the PPG sensors in conjunction with breathing sensors, it has been possible to monitor the 0.125 to 0.15 Hz rhythms in the arterial volumetric changes and to study the influence of breathing on them. These rhythms, which according to medical experts have relevance to psychosomatic conditions e.g. stress or relaxation, can also be addressed to by ancient Indian practices like yoga and meditation. This book presents the results of studying the effects of Indian relaxation techniques like pranayama, meditation, etc. in comparison to western relaxation techniques like autogenic training. So far it has been established that the Indian techniques of relaxation like yoga and meditation are very effective in generating low frequency rhythms in the skin perfusion as monitored by optical sensors. According to medical experts, these low frequency rhythms have a very important bearing on the human physiology and have potential therapeutic implications. This book is meant to provide an overview of the current state-of-knowledge and encourage the next generation of scientists/engineers to carry this work forward, especially on the novel PPG application fields that are of growing importance like pain and stress assessment, detection of peripheral venous saturation and local arterio-venous oxygen consumption as well as contactless space resolved skin perfusion studies with modern camera based PPG technology.

This books provides up-to-date reviews on current advances of the role of HSP in veterinary medicine and research. Key basic and clinical research laboratories from major universities, veterinary hospitals and pharmaceutical companies around the world have contributed chapters that review present research activity and importantly project this field into the future. For easy readability, the book is sub divided into sections on HSP in the following aspects of Veterinary Medicine, including, I - Domestic Animals, II - Poultry, III - Aquatic and IV - Parasites. The book is a must read for heat shock protein researchers in general and specifically those involved in clinical and research in veterinary medicine.

This thesis discusses the evolution of galaxies through the study of the morphology, kinematics, and star formation properties of a sample of nearby galaxies. The main body of the thesis describes the kinematic observations with the GHaFAS Fabry-Perot instrument on the William Herschel Telescope of a sample of 29 spiral galaxies. The work is closely related to the Spitzer Survey of Stellar Structure in Galaxies, and uses the mid-infrared data of that survey to determine key parameters of the galaxies studied. From these data, important results are obtained on streaming and other non-circular motions in galaxies, on the distribution and rates of star formation, and on how correlations of these parameters and of the rotation curve shape with basic galaxy parameters yield clues on the evolutionary processes taking place in disk galaxies.

Cold atmospheric plasma (CAP) emerges as a possible new modality for cancer treatment. This book provides a comprehensive introduction into fundamentals of the CAP and plasma devices used in plasma medicine. An analysis of the mechanisms of plasma interaction with cancer and normal cells including description of possible mechanisms of plasma selectivity is included. Recent advances in the field, the primary challenges and future directions are presented.

This detailed book systematically investigates subsurface geological fractures using rock mechanics, geology, and geophysics. Based on geological fracture mechanisms and fracture boundary conditions, it presents new finite-difference equations for the simulation of seismic wave responses to geological fractures, and proposes innovative AVO inversion equations for the accurate estimation of the rock properties of the fractured medium. It employs schematics, snapshots, color images and charts to demonstrate the mechanical characteristics of the fractures, the seismic wave-field response to the fractures, the seismic data attributes of the fractures and the rock properties of the fractures obtained via inversion. It provides a new methodology for enhancing geological fracture detection technology and for the accurate delineation of fractured reservoirs that ultimately benefits reservoir and mining engineers, geologists and geophysicists in terms of optimizing reservoir recovery, well performance and mining safety.

This book on space geodesy presents pioneering geometrical approaches in the modelling of satellite orbits and gravity field of the Earth, based on the gravity field missions CHAMP, GRACE and GOCE in the LEO orbit. Geometrical approach is also extended to precise positioning in space using multi-GNSS constellations and space geodesy techniques in the realization of the terrestrial and celestial reference frame of the Earth. This book addresses major new developments that were taking place in space geodesy in the last decade, namely the availability of GPS receivers onboard LEO satellites, the multitude of the new GNSS satellite navigation systems, the huge improvement in the accuracy of satellite clocks and the revolution in the determination of the Earth's gravity field with dedicated satellite missions.

This book focuses on understanding the stellar populations of massive star clusters and aims to investigate the origin, evolution and properties of binary systems, their collision products, as well as the general characteristics (e.g. ages, metal content) of stellar population(s) in star clusters. It introduces the basic background knowledge of various stellar populations in star clusters as well as their formation, interaction and evolution and offers high impact observational results on our understanding of the formation and evolution mode of star clusters. Based on these discoveries, this book proposes a series of future projects that can shed light on these topics. The research introduced in this book reveals key features of star clusters formation and by extension how all stars formed in our universe.

An almost complete collection of the papers given at the International Workshop on Imaging in High Energy Astronomy (Anacapri, Italy, 1994). These proceedings, which concentrate on imaging above 10 keV, represent the state of the art in the field, resulting from the success of many missions (I.C. Granat and CGRO) carrying detectors for high energy astronomy with imaging capabilities. The main topics of the book are Bragg concentrators, coded mask-modulation collimators, double Compton telescopes, the occultation method, tracking chambers, and new experimental techniques. The book also contains some papers dealing with image reconstruction and processing, with an emphasis on the above techniques.

This book presents the first overview of the composition and structure of the Earth's lower mantle. The first part focuses on the study of lower-mantle minerals, identified as inclusions in diamonds from different regions of the world. Three associations are established among the lower-mantle minerals: ultramafic, mafic, and carbonatic. The carbonatic association is of particular interest because it characterizes the media of natural diamond formation. In turn, the second part analyzes the structure of the lower mantle, revealing its heterogeneous composition. It is based on the results of experiments demonstrating phase transitions in lower-mantle minerals, and on seismological data. Deep-seated earthquakes point to the presence within the lower mantle of numerous seismic boundaries caused by mineral structure transitions. In closing, the last part of the book compares observed data with experimental data, highlighting several discrepancies that indicate Earth may have a more complex planetary history than previously assumed, and examining its primarily non-chondritic composition.

This book presents not only the simultaneous combination of optical methods based on holographic principles for marker-free imaging, real-time trapping, identification and tracking of micro objects, but also the application of substantial low coherent light sources and non-diffractive beams. It first provides an overview of digital holographic microscopy (DHM) and holographic optical tweezers as well as non-diffracting beam types for minimal-invasive, real-time and marker-free imaging as well as manipulation of micro and nano objects. It then investigates the design concepts for the optical layout of holographic optical tweezers (HOTs) and their optimization using optical simulations and experimental methods. In a further part, the book characterizes the corresponding system modules that allow the addition of HOTs to commercial microscopes with regard to stability and diffraction efficiency. Further, based on experiments and microfluidic applications, it demonstrates the functionality of the combined setup, and discusses several types of non-diffracting beams and their application in optical manipulation. The book shows that holographic optical tweezers, including several non-diffracting beam types like Mathieu beams, combined parabolic and Airy beams, not only open up the possibility of generating efficient multiple dynamic traps for micro and nano particles with forces in the pico and nano newton range, but also the opportunity to exert optical torque with special beams like Bessel beams, which can facilitate the movement and rotation of particles by generating microfluidic flows. The last part discusses the potential use of a slightly modified DHM-HOT-system to explore the functionality of direct laser writing based on a two photon absorption process in a negative photoresist with a continuous wave laser

This thesis addresses two very different but equally important topics in the very broad fields of astrophysics and cosmology: (I) the generation of cosmological magnetic fields and (II) gravitational fragmentation of the Cosmic Web. All mathematical developments are completed by illuminating physical interpretations, and the thesis, which is guided by existing observations, is purely theoretical. In part I, the author further develops a magnetogenesis model proposed in the literature, providing an unprecedented level of physical understanding. He demonstrates that the physics of photoionisation is very likely to have premagnetised, at a relevant level, the entire Universe at the early epoch of the formation of the first luminous sources. In part II, the author adapts the tools of plasma spectral theory to the context of gravitational instability of the baryonic gas within the stratified structures of the Cosmic Web. He skillfully derives the wave equation governing the growth of perturbations and explores various equilibrium configurations, in planar and cylindrical geometries characteristic of cosmic walls and filaments, for isothermal and polytropic conditions, with or without an external gravitational background. Clearly structured and written in pedagogical style, this outstanding thesis puts the results into perspective and highlights the merits and limitations of the various approaches explored.

This prizewinning PhD thesis presents a general discussion of the orbital motion close to solar system small bodies (SSSBs), which induce non-central asymmetric gravitational fields in their neighborhoods. It introduces the methods of qualitative theory in nonlinear dynamics to the study of local/global behaviors around SSSBs. Detailed mechanical models are employed throughout this dissertation, and specific numeric techniques are developed to compensate for the difficulties of directly analyzing. Applying this method, several target systems, like asteroid 216 Kleopatra, are explored in great detail, and the results prove to be both revealing and pervasive for a large group of SSSBs.

This book presents various examples of how advanced fluorescence and spectroscopic analytical methods can be used in combination with computer data processing to address different biochemical questions. The main focus is on evolutionary biochemistry and the description of biochemical and metabolic issues; specifically, the use of pulse amplitude modulated fluorescence (PAM) for the functional analysis of the cellular state, as well as results obtained by means of the derivative spectroscopy method characterizing structural reorganization of a cell under the influence of external factors, are discussed. The topics presented here will be of interest to biologists, geneticists, biophysicists and biochemists, as well as experts in analytical chemistry, pharmaceutical chemistry and radio chemistry and radio activation studies with protonen and alpha-particles. It also offers a valuable resource for advanced undergraduate and graduate students in biological, physical and chemical disciplines whose work involves derivative spectrophotometry and PAM-fluorescence.

This volume collects the contributions to the 10th European Workshop on White Dwarfs held in Blanes, Spain, in June 1996. The Workshop gathered together a number of specialists working in this area of research and provided an updated description of the current work of the field as well as its connections with other topics. This text provides a snapshot of current understanding of the origin, structure and evolution of white dwarf stars from both the theoretical and the observational points of view. It also takes into account the properties of white dwarfs as members of binary systems, stellar clusters and galactic populations.

This book presents cutting-edge research on the use of physical and mathematical formalisms to model and quantitatively analyze biological phenomena ranging from microscopic to macroscopic systems. The systems discussed in this compilation cover protein folding pathways, gene regulation in prostate cancer, quorum sensing in bacteria to mathematical and physical descriptions to analyze anomalous diffusion in patchy environments and the physical mechanisms that drive active motion in large sets of particles, both fundamental descriptions that can be applied to different phenomena in biology. All chapters are written by well-known experts on their respective research fields with a vast amount of scientific discussion and references in order the interested reader can pursue a further reading. Given these features, we consider Quantitative Models for Microscopic to Macroscopic Biological Macromolecules and Tissues as an excellent and up-to-date resource and reference for advanced undergraduate students, graduate students and junior researchers interested in the latest developments at the intersection of physics, mathematics, molecular biology, and computational sciences. Such research field, without hesitation, is one of the most interesting, challenging and active of this century and the next.

This accessible and entertaining biography chronicles the life and triumphs of astronomer Jan Hendrik Oort, who helped lay the foundations of modern astronomy in the 20th century. The book puts into context some of Oort's most significant achievements, including his discovery that the Milky Way rotates, as well as his famous hypothesis that our Solar System is surrounded by a reservoir of comets - now simply known as the Oort Cloud. Written by Oort's former student, this fascinating story also delves into Oort's pivotal role in the foundation of major astronomical facilities, including radio telescopes in the Netherlands and the European Southern Observatory (ESO), which now operates the most successful astronomical observatories in the world. The book draws extensively on new archival research through the Oort Archives, along with personal reminiscences by Oort's son and astronomer-grandson, to paint a more detailed picture of Oort's life not just as an astronomer, but also as a husband, father, and citizen. The strong public interest in comets triggered by the Rosetta mission to comet 67P/Churyumov-Gerasimenko and the recently discovered interstellar comet in the Solar System make this book particularly timely.