This book introduces readers to MesoBioNano (MBN) Explorer - a multi-purpose software package designed to model molecular systems at various levels of size and complexity. In addition, it presents a specially designed multi-task toolkit and interface - the MBN Studio - which enables the set-up of input files, controls the simulations, and supports the subsequent visualization and analysis of the results obtained. The book subsequently provides a systematic description of the capabilities of this universal and powerful software package within the framework of computational molecular science, and guides readers through its applications in numerous areas of research in bio- and chemical physics and material science - ranging from the nano- to the mesoscale. MBN Explorer is particularly suited to computing the system's energy, to optimizing molecular structure, and to exploring the various facets of molecular and random walk dynamics. The package allows the use of a broad variety of interatomic potentials and can, e.g., be configured to select any subset of a molecular system as rigid fragments, whenever a significant reduction in the number of dynamical degrees of freedom is required for computational practicalities. MBN Studio enables users to easily construct initial geometries for the molecular, liquid, crystalline, gaseous and hybrid systems that serve as input for the subsequent simulations of their physical and chemical properties using MBN Explorer. Despite its universality, the computational efficiency of MBN Explorer is comparable to that of other, more specialized software packages, making it a viable multi-purpose alternative for the computational modeling of complex molecular systems. A number of detailed case studies presented in the second part of this book demonstrate MBN Explorer's usefulness and efficiency in the fields of atomic clusters and nanoparticles, biomolecular systems, nanostructured materials, composite materials and hybrid systems, crystals, liquids and gases, as well as in providing modeling support for novel and emerging technologies. Last but not least, with the release of the 3rd edition of MBN Explorer in spring 2017, a free trial version will be available from the MBN Research Center website (mbnresearch.com).

This book provides detailed calculated values for the thermal radiative and thermodynamic functions of black-body radiation in finite spectral ranges. The results are presented in tabular form. The areas of thermal power generation, infrared medical diagnostics, solar power and nuclear generation, and astrophysics are included. A range of the thermal radiative and thermodynamic functions are calculated by the authors in the finite frequency/wavenumber/wavelength intervals at different temperatures. This book also contains the tables of the chromaticity coordinates and RGB parameters calculated for different color spaces (Rec.709 (HDTV), sRGB, Adobe RGB). A number of the optimization problems is formulated and solved for various thermal black-body radiative and thermodynamic functions in a finite range of frequencies.

The focus of this book is the remarkable advances in understanding of low pressure RF (radio frequency) glow discharges. A basic analytical theory and plasma physics are explained. Plasma diagnostics are also covered before the practicalities of etcher use are explored.

This textbook provides an accessible introduction to physics for undergraduate students in the life sciences, including those majoring in all branches of biology, biochemistry, and psychology and students working on pre-professional programs such as pre-medical, pre-dental, and physical therapy. The text is geared for the algebra-based physics course, often named College Physics in the United States. The order of topics studied are such that most of the problems in the text can be solved with the methods of Statics or Dynamics. That is, they require a free body diagram, the application of Newton’s Laws, and any necessary kinematics. Constructing the text with a standardized problem-solving methodology, simplifies this aspect of the course and allows students to focus on the application of physics to the study of biological systems. Along the way, students apply these techniques to find the tension in a tendon, the sedimentation rate of red blood cells in haemoglobin, the torques and forces on a bacterium employing a flagellum to propel itself through a viscous fluid, and the terminal velocity of a protein moving in a Gel Electrophoresis device. This is part one of a two-volume set; volume 2 introduces students to the conserved-quantities and applies these problem-solving techniques to topics in Thermodynamics, Electrical Circuits, Optics, and Atomic and Nuclear Physics always with continued focus on biological applications.

This book is the first to focus specifically on cancer nanotheranostics. Each of the chapters that make up this comprehensive volume is authored by a researcher, clinician, or regulatory agency member known for their expertise in this field. Theranostics, the technology to simultaneously diagnose and treat a disease, is a nascent field that is growing rapidly in this era of personalized medicine. As the need for cost-effective disease diagnosis grows, drug delivery systems that can act as multifunctional carriers for imaging contrast and therapy agents could provide unique breakthroughs in oncology. Nanotechnology has enabled the development of smart theranostic platforms that can concurrently diagnose disease, start primary treatment, monitor response and initiate secondary treatments if required. In oncology, chemotherapeutics have been routinely used. Some drugs have proven effective but all carry risks of adverse side effects. There is growing interest in using remotely triggered drug delivery systems to limit cytotoxicity in the diseased area. This book reviews the use of theranostic nanoparticles for cancer applications over the past decade. First, it briefly discusses the challenges and limitations of conventional cancer treatments, and presents an overview of the use of nanotechnology in treating cancer. These introductory chapters are followed by those exploring cancer diagnosis and a myriad of delivery methods for nanotherapeutics. The book also addresses multifunctional platforms, treatment monitoring, and regulatory considerations. As a whole, the book aims to briefly summarize the development and clinical potential of various nanotheranostics for cancer applications, and to delineate the challenges that must be overcome for successful clinical development and implementation of such cancer theranostics.

This book explains the anatomy and physiology of cartilage tissue in an integrated way. The emphasis is on how cartilage tissue functions and maintains homeostasis in a challenging mechanical environment. Supported by hundreds of references, the book posts new hypotheses explaining how cartilage adapts and achieves homeostasis in vivo, and tests them against available data. This exploratory approach creates a sense of discovery that the reader can join, or perhaps test themselves through their own research. The main benefit will be obtained by research students and professors looking to understand the deeper concepts that will further their own research, or clinicians (including health professionals and surgeons) who want to gain a deeper physiological understanding of cartilage tissue, which can then serve as a basis for more rational clinical decision-making they need to make on a daily basis. To help bridge the gap between basic science and clinically relevant joint disease, applications and interpretations of key physiological concepts are discussed in the context of osteoarthritis at the end of most chapters.

This book uses new data from the very low radio frequency telescope LOFAR to analyse the magnetic structure in the giant radio galaxy NGC6251. This analysis reveals that the magnetic field strength in the locality of this giant radio galaxy is an order of magnitude lower than in other comparable systems. Due to the observational limitations associated with capturing such huge astrophysical structures, giant radio galaxies are historically a poorly sampled population of objects; however, their preferential placement in the more rarefied regions of the cosmic web makes them a uniquely important probe of large-scale structures. In particular, the polarisation of the radio emissions from giant radio galaxies is one of the few tools available to us that can be used to measure magnetic fields in regions where the strength of those fields is a key differentiator for competing models of the origin of cosmic magnetism. Low frequency polarisation data are crucial for detailed analyses of magnetic structure, but they are also the most challenging type of observational data to work with. This book presents a beautifully coupled description of the technical and scientific analysis required to extract valuable information from such data and, as the new generation of low frequency radio telescopes reveals the larger population of giant radio galaxies, it offers a significant resource for future analyses.

This book on space geodesy presents pioneering geometrical approaches in the modelling of satellite orbits and gravity field of the Earth, based on the gravity field missions CHAMP, GRACE and GOCE in the LEO orbit. Geometrical approach is also extended to precise positioning in space using multi-GNSS constellations and space geodesy techniques in the realization of the terrestrial and celestial reference frame of the Earth. This book addresses major new developments that were taking place in space geodesy in the last decade, namely the availability of GPS receivers onboard LEO satellites, the multitude of the new GNSS satellite navigation systems, the huge improvement in the accuracy of satellite clocks and the revolution in the determination of the Earth's gravity field with dedicated satellite missions.

The investigation of discrete symmetries is a fascinating subject which has been central to the agenda of physics research for 50 years, and has been the target of many experiments, ongoing and in preparation, all over the world. This book approaches the subject from a somewhat less traditional angle: while being self-contained and suitable to the reader who wants to acquire a solid knowledge of the topic, it puts more emphasis on the experimental aspects of the field, trying to provide a wider picture than usual and to convey the intellectual challenge of experimental physics. The book includes the related connection to phenomenology, a purpose for which the precision experiments in this field - often rather elegant and requiring a good amount of ingenuity - are very well suited. The book discusses discrete symmetries (parity, charge conjugation, time reversal, and of course CP symmetry) in microscopic (atomic, nuclear, and particle) physics, and includes the detailed description of some key or representative experiments. The book discusses their principles and challenges more than the historical development. The main past achievements and the most recent developments are both included. The level goes from introductory to advanced. While mainly addressed to graduate students, the book can also be useful to undergraduates (by skipping some of the more advanced sections, and utilizing the brief introductions to some topics in the appendices), and to young researchers looking for a wider modern overview of the issues related to CP symmetry.

This thesis focuses on the very high Mach number shock wave that is located sunward of Saturn's strong magnetic field in the continuous high-speed flow of charged particles from the Sun (the solar wind). The author exploits the fact that the Cassini spacecraft is the only orbiter in a unique parameter regime, far different from the more familiar near-Earth space, to provide in-situ insights into the unreachable exotic regime of supernova remnants. This thesis bridges the gap between shock physics in the Solar System and the physics of ultra-high Mach number shocks around the remnants of supernova explosions, since to date research into the latter has been restricted to theory, remote observations, and simulations.

This book presents the first overview of the composition and structure of the Earth's lower mantle. The first part focuses on the study of lower-mantle minerals, identified as inclusions in diamonds from different regions of the world. Three associations are established among the lower-mantle minerals: ultramafic, mafic, and carbonatic. The carbonatic association is of particular interest because it characterizes the media of natural diamond formation. In turn, the second part analyzes the structure of the lower mantle, revealing its heterogeneous composition. It is based on the results of experiments demonstrating phase transitions in lower-mantle minerals, and on seismological data. Deep-seated earthquakes point to the presence within the lower mantle of numerous seismic boundaries caused by mineral structure transitions. In closing, the last part of the book compares observed data with experimental data, highlighting several discrepancies that indicate Earth may have a more complex planetary history than previously assumed, and examining its primarily non-chondritic composition.

Of Clocks and Time takes readers on a five-stop journey through the physics and technology (and occasional bits of applications and history) of timekeeping. On the way, conceptual vistas and qualitative images abound, but since mathematics is spoken everywhere the book visits equations, quantitative relations, and rigorous definitions are offered as well. The expedition begins with a discussion of the rhythms produced by the daily and annual motion of sun, moon, planets, and stars. Centuries worth of observation and thinking culminate in Newton's penetrating theoretical insights since his notion of space and time are still influential today. During the following two legs of the trip, tools are being examined that allow us to measure hours and minutes and then, with ever growing precision, the tiniest fractions of a second. When the pace of travel approaches the ultimate speed limit, the speed of light, time and space exhibit strange and counter-intuitive traits. On this fourth stage of the journey, Einstein is the local tour guide whose special and general theories of relativity explain the behavior of clocks under these circumstances. Finally, the last part of the voyage reverses direction, moving ever deeper into the past to explore how we can tell the age of "things" - including that of the universe itself.

This book lays the foundations of gas- and fluid dynamics.The basic equations are developed from first principles, building on the (assumed) knowledge of Classical Mechanics. This leads to the discussion of the mathematical properties of flows, conservation laws, perturbation analysis, waves and shocks. Most of the discussion centers on ideal (frictionless) fluids and gases. Viscous flows are discussed when considering flows around obstacles and shocks. Many of the examples used to illustrate various processes come from astrophysics and geophysical phenomena.

The Textbook of Ion Channels is a set of three volumes providing a wide-ranging reference source on ion channels for students, instructors, and researchers. Ion channels are membrane proteins that control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli like light, sound, odor, and taste, and regulate the response to physical stimuli like temperature and pressure. In non-excitable tissues, ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells, giving them the unique ability to communicate with the environment, as well as the membrane of intracellular organelles, allowing them to regulate internal homeostasis. Ion channels are fundamentally important for human health and diseases, and are important targets for pharmaceuticals in mental illness, heart disease, anesthesia, pain and other clinical applications. The modern methods used in their study are powerful and diverse, ranging from single ion-channel measurement techniques to models of ion channel diseases in animals, and human clinical trials for ion channel drugs. All three volumes give the reader an introduction to fundamental concepts needed to understand the mechanism of ion channels, a guide to the technical aspects of ion channel research, offer a modern guide to the properties of major ion channel families, and include coverage of key examples of regulatory, physiological, and disease roles for ion channels.

This thesis addresses two very different but equally important topics in the very broad fields of astrophysics and cosmology: (I) the generation of cosmological magnetic fields and (II) gravitational fragmentation of the Cosmic Web. All mathematical developments are completed by illuminating physical interpretations, and the thesis, which is guided by existing observations, is purely theoretical. In part I, the author further develops a magnetogenesis model proposed in the literature, providing an unprecedented level of physical understanding. He demonstrates that the physics of photoionisation is very likely to have premagnetised, at a relevant level, the entire Universe at the early epoch of the formation of the first luminous sources. In part II, the author adapts the tools of plasma spectral theory to the context of gravitational instability of the baryonic gas within the stratified structures of the Cosmic Web. He skillfully derives the wave equation governing the growth of perturbations and explores various equilibrium configurations, in planar and cylindrical geometries characteristic of cosmic walls and filaments, for isothermal and polytropic conditions, with or without an external gravitational background. Clearly structured and written in pedagogical style, this outstanding thesis puts the results into perspective and highlights the merits and limitations of the various approaches explored.

This prizewinning PhD thesis presents a general discussion of the orbital motion close to solar system small bodies (SSSBs), which induce non-central asymmetric gravitational fields in their neighborhoods. It introduces the methods of qualitative theory in nonlinear dynamics to the study of local/global behaviors around SSSBs. Detailed mechanical models are employed throughout this dissertation, and specific numeric techniques are developed to compensate for the difficulties of directly analyzing. Applying this method, several target systems, like asteroid 216 Kleopatra, are explored in great detail, and the results prove to be both revealing and pervasive for a large group of SSSBs.

In his PhD dissertation Martin Bo Nielsen performs observational studies of rotation in stars like the Sun. The interior rotation in stars is thought to be one of the driving mechanisms of stellar magnetic activity, but until now this mechanism was unconstrained by observational data. NASA's Kepler space mission provides high-precision observations of Sun-like stars which allow rotation to be inferred using two independent methods: asteroseismology measures the rotation of the stellar interior, while the brightness variability caused by features on the stellar surface trace the rotation of its outermost layers. By combining these two techniques Martin Bo Nielsen was able to place upper limits on the variation of rotation with depth in five Sun-like stars. These results suggest that the interior of other Sun-like stars also rotate in much the same way as our own Sun.

This book is an in-depth treatment of the theoretical background relevant to an understanding of materials that can be obtained by using high-energy electron diffraction and microscopy.

This thesis describes novel substrate embedded physical sensors that can be used to monitor different types of cell-based assays non-invasively and label-free. The sensors described provide integrative information of the cells under study with an adaptable time resolution (ranging from milliseconds to days). This information about the dynamic cell response to chemical, physical or biological stimuli defines a new paradigm in fundamental biomedical research. The author, Maximilian Oberleitner, describes approaches in which the cells are directly grown on different sensor surfaces (gold-film electrodes, shear wave resonators or dye-doped polymer films). This approach, with the reacting cells in particularly close proximity and contact with the sensor surface, is key to a remarkable sensitivity, opening the way for a variety of new applications. This thesis not only introduces the fundamentals of each approach, but it also describes in great detail the design principles and elucidates the boundary conditions of the new sensors.

Explores the many facets of redox exchanges that drive magma's behavior and evolution, from the origin of the Earth until today The redox state is one of the master variables behind the Earth's forming processes, which at depth concern magma as the major transport agent. Understanding redox exchanges in magmas is pivotal for reconstructing the history and compositional make-up of our planet, for exploring its mineral resources, and for monitoring and forecasting volcanic activity. Magma Redox Geochemistry describes the multiple facets of redox reactions in the magmatic realm and presents experimental results, theoretical approaches, and unconventional and novel techniques. Volume highlights include: Redox state and oxygen fugacity: so close, so far Redox processes from Earth's accretion to global geodynamics Redox evolution from the magma source to volcanic emissions Redox characterization of elements and their isotopes The American Geophysical Union promotes discovery in Earth and space science for the benefit of humanity. Its publications disseminate scientific knowledge and provide resources for researchers, students, and professionals.

This book focuses on the mechanobiological principles in tissue engineering with a particular emphasis on the multiscale aspects of the translation of mechanical forces from bioreactors down to the cellular level. The book contributes to a better understanding of the design and use of bioreactors for tissue engineering and the use of mechanical loading to optimize in vitro cell culture conditions. It covers experimental and computational approaches and the combination of both to show the benefits that computational modelling can bring to experimentalists when studying in vitro cell culture within a scaffold. With topics from multidisciplinary fields of the life sciences, medicine, and engineering, this work provides a novel approach to the use of engineering tools for the optimization of biological processes and its application to regenerative medicine. The volume is a valuable resource for researchers and graduate students studying mechanobiology and tissue engineering. For undergraduate students it also provides deep insight into tissue engineering and its use in the design of bioreactors. The book is supplemented with extensive references for all chapters to help the reader to progress through the study of each topic.

In this provocative text, a noted neuroscientist reexamines Freud's posthumously published Project of Scientific Psychology in the light of modern neuroscience. This expanded "thermodynamics of the mind" model includes robust conceptions of the cellular and neural processes that accompany creation of consciousness and memory, their contributions to such conditions as depression, dissociative disorders, and schizophrenia, and implications for practice, from imaging to talk-based therapies to pharmacotherapy. Central to this construct is Freud's proposal of specific "omega" neurons as the most volatile carriers of consciousness between mind and brain, which is applied to current issues regarding complexity and executive functioning. In addition, the book is extensively referenced, allowing readers to investigate these and related phenomena in greater detail. Among the topics covered: Neural reductionism in Freud's "Project" and neuropsychoanalysis. Thermodynamics and brain self-organization. Conflicting information and the dissociated mind. The Cartesian model of the mind and the binding problem. Neuroendocrine and immune response to stress. The concept of omega neurons and modern chaos theory. Rigorous, challenging, and occasionally startling, The Brain and Conscious Unity is a milestone in the neuroscience and mind/brain literature to be read and discussed by psychiatrists, psychologists, and neuropsychologists.

This thesis describes the application of a Monte Carlo radiative transfer code to accretion disc winds in two types of systems spanning 9 orders of magnitude in mass and size. In both cases, the results provide important new insights. On small scales, the presence of disc winds in accreting white dwarf binary systems has long been inferred from the presence of ultraviolet absorption lines. Here, the thesis shows that the same winds can also produce optical emission lines and a recombination continuum. On large scales, the thesis constructs a simple model of disc winds in quasars that is capable of explaining both the observed absorption and emission signatures - a crucial advance that supports a disc-wind based unification scenario for quasars. Lastly, the thesis also includes a theoretical investigation into the equivalent width distribution of the emission lines in quasars, which reveals a major challenge to all unification scenarios.