This book provides an introduction to design of biomedical optical imaging technologies and their applications. The main topics include: fluorescence imaging, confocal imaging, micro-endoscope, polarization imaging, hyperspectral imaging, OCT imaging, multimodal imaging and spectroscopic systems.

Each chapter is written by the world leaders of the respective fields, and will cover:

principles and limitations of optical imaging technology, system design and practical implementation for one or two specific applications, including design guidelines, system configuration, optical design, component requirements and selection, system optimization and design examples, recent advances and applications in biomedical researches and clinical imaging.

This book serves as a reference for students and researchers in optics and biomedical engineering.

After an insightful introductory part on recent developments in the thermodynamics of small systems, the author presents his contribution to a long-standing problem, namely the connection between irreversibility and dissipation. He develops a method based on recent results on fluctuation theorems that is able to estimate dissipation using only information acquired in a single, sufficiently long, trajectory of a stationary nonequilibrium process. This part ends with a remarkable application of the method to the analysis of biological data, in this case, the fluctuations of a hair bundle.

The third part studies the energetics of systems that undergo symmetry breaking transitions. These theoretical ideas lead to, among other things, an experimental realization of a Szilard engine using manipulated colloids.

This work has the potential for important applications ranging from the analysis of biological media to the design of novel artificial nano-machines.

Volume 37 is concerned with the use and role of modelling in chemical kinetics and seeks to show the interplay of theory or simulation with experiment in a diversity of physico-chemical areas in which kinetics measurements provide significant physical insight. Areas of application covered within the volume include electro- and interfacial chemistry, physiology, biochemistry, solid state chemistry and chemical engineering.
A leading contributor to this general area has been Professor W. John Albery, FRS, to whom the contributors and editors dedicate this book.

The monograph discusses models of synthetic protocells, which are cell-like structures obtained from non-living matter endowed with some rudimentary kind of metabolism and genetics, but much simpler than biological cells. They should grow and proliferate, generating offsprings that resemble in some way the parent protocells with some variation, so that selection may take place. Sustainable protocell populations have not yet been obtained experimentally and mathematical models are therefore extremely important to address key questions concerning their synthesis and behavior. Different protocell "architectures" have been proposed and high-level abstract models like those that are presented in this book are particularly relevant to gain a better understanding of the different properites. These models are able to treat all the major dynamical phenomena in a unified framework, so they can be seen as "virtual laboratories" for protocell research. Particular attention is paid to the problem of synchronization of the fission rate of the whole protocell and the duplication rate of its "protogenetic" material, which is shown to be an emergent property that spontaneously develops in successive generations. The book is of interest for a broad range of scientists working in soft matter physics, chemistry and biology, interested in the role protocells may play on the development of new technologies with medical, environmental and industrial applications as well as scientists interested in the origin of life.

This book presents the first compilation of scientific research on the island of Nisyros, involving various geoscientific disciplines. Presenting a wealth of illustrations and maps, including a geological map of the volcano, it also provides valuable insights into the geothermal potential of Greece. The island of Nisyros is a Quaternary volcano located at the easternmost end of the South Aegean Volcanic Arc. The island is nearly circular, with an average diameter of 8 km, and covers an area of approximately 42 km2. It lies above a base of Mesozoic limestone and a thin crust, with the mantle-crust transition located at a depth of approximately 27 km. The volcanic edifice of Nisyros comprises a succession of calc-alkaline lavas and pyroclastic rocks, as well as a summit caldera with an average diameter of 4 km. Nisyros marks the most recent volcano in the large prehistoric volcanic field between Kos-Yali-Strongyli-Pyrgousa-Pachia-Nisyros, where the largest eruption ("Kos Plateau Tuff") in the history of the eastern Mediterranean devastated the Dodecanese islands 161,000 years ago. Although the last volcanic activity on Nisyros dates back at least 20,000 to 25,000 years, it encompasses an active hydrothermal system underneath the volcano with temperatures of roughly 100 DegreesC at the Lakki plain, the present-day caldera floor and 350 DegreesC at a depth of 1,550 m. A high level of seismic unrest, thermal waters and fumarolic gases bear testament to its continuous activity, which is due to a large volume of hot rocks and magma batches at greater depths, between 3,000 and 8,000 m. Violent hydrothermal eruptions accompanied by major earthquakes occurred in 1873 and 1888 and left behind large, "world-wide unique" explosion craters in the old caldera. Through diffuse soil degassing, the discharge of all hydrothermal craters in the Lakki plain releases 68 tons of hydrothermal-volcanic derived CO2 and 42 MW of thermal energy per day. This unique volcanic and hydrothermal environment is visited daily by hundreds of tourists.

This book addresses two fundamental issues of motor control for both humans and robots: kinematic redundancy and the posture/movement problem. It blends traditional robotic constrained-optimal approaches with neuroscientific and evidence-based principles, proposing a "Task-space Separation Principle," a novel scheme for planning both posture and movement in redundant manipulators. The proposed framework is first tested in simulation and then compared with experimental motor strategies displayed by humans during redundant pointing tasks. The book also shows how this model builds on and expands traditional formulations such as the Passive Motion Paradigm and the Equilibrium Point Theory. Lastly, breaking with the neuroscientific tradition of planar movements and linear(ized) kinematics, the theoretical formulation and experimental scenarios are set in the nonlinear space of 3D rotations which are essential for wrist motions, a somewhat neglected area despite its importance in daily tasks.

This book provides a general introduction to the rapidly developing astrophysical frontier of stellar tidal disruption, but also details original thesis research on the subject. This work has shown that recoiling black holes can disrupt stars far outside a galactic nucleus, errors in the traditional literature have strongly overestimated the maximum luminosity of "deeply plunging" tidal disruptions, the precession of transient accretion disks can encode the spins of supermassive black holes, and much more. This work is based on but differs from the original thesis that was formally defended at Harvard, which received both the Roger Doxsey Award and the Chambliss Astronomy Achievement Student Award from the American Astronomical Society.

This book contains contributions to the 32nd Polish-Czech-Slovak Symposium on Mining and Environmental Geophysics held in May 2009 in Piechowice (Poland). The papers are related to various aspects of geophysical science such as induced seismicity, engineering seismology, environmental geophysics and geophysics in geology

This book presents an analysis of our current knowledge on the origin of the Earth's continental crust. There are two aspects to consider: tectonic and igneous processes. Tectonic aspects include sedimentary accretion, terrane accretion, and continental collision at continental margins, in association with plate subduction. These processes result in the formation of large mountain belts, the building up of which literally grows the continents. However, these tectonic aspects are concerned with material recycling within the crust, and hence do not contribute to volumetric growth of continental crust. Igneous processes concern separation of continental crust from the mantle and result in the volumetric growth of continental crust. Therefore, the main focus of this book is to systematically examine why and how the Earth's continental crust forms, by evaluating magmatic processes at island arcs where new continental crust forms.

This monograph is the last volume in the series 'Acoustic and Elastic
Wave Fields in Geophysics'. The previous two volumes published by Elsevier (2000, 2002) dealt mostly with wave propagation in liquid media.

The third volume is dedicated to propagation of plane, spherical and cylindrical elastic waves in different media including isotropic and transversely isotropic solids, liquid-solid models, and media with cylindrical inclusions (boreholes).
* Prevalence of physical reasoning on formal mathematical derivations
* Readers do not need to have a strong background in mathematics and mathematical physics
* Detailed analysis of wave phenomena in various types of elastic and liquid-elastic media

How does it happen that billions of stars can cooperate to produce the beautiful spirals that characterize so many galaxies, including ours? This book reviews the history behind the discovery of spiral galaxies and the problems faced when trying to explain the existence of spiral structure within them. In the book, subjects such as galaxy morphology and structure are addressed as well as several models for spiral structure. The evidence in favor or against these models is discussed. The book ends by discussing how spiral structure can be used as a proxy for other properties of spiral galaxies, such as their dark matter content and their central supermassive black hole masses, and why this is important.

In tropical latitudes, monsoons trigger regimes of strong seasonal rainfall over the continents. Over the West African region, the rainfall has shown a strong variability from interannual to decadal time scales. The atmospheric response to global sea surface temperatures is the leading cause of rainfall variability in the West African Sahel. This thesis explores changes in the leading ocean forcing of Sahelian rainfall interannual variability. It anaylzes the dynamical mechanisms at work to explain the non-stationary sea surface temperature-forced response of anomalous rainfall. The underlying multidecadal sea surface temperature background is raised as a key factor that favors some interannual teleconnections and inhibits others. Results of this thesis are relevant for improving the seasonal predictability of summer rainfall in the Sahel.

The invention of the semiconductor laser along with silica glass fiber has enabled an incredible revolution in global communication infrastructure of direct benefit to all. Development of devices and system concepts that exploit the same fundamental light-matter interaction continues. Researchers and technologists are pursuing a broad range of emerging applications, everything from automobile collision avoidance to secure quantum key distribution. This book sets out to summarize key aspects of semiconductor laser device physics and principles of laser operation. It provides a convenient reference and essential knowledge to be understood before exploring more sophisticated device concepts. The contents serve as a foundation for scientists and engineers, without the need to invest in specialized detailed study. Supplementary material in the form of MATLAB is available for numerically generated figures.

Titanium dioxide photocatalysis is based on the semiconducting nature of its anatase crystal type. Construction materials with titanium photocatalyst show performances of air purification, self-cleaning, water purification, antibacterial action. This book describes principles of titanium dioxide photocatalysis, its applications to cementitious and noncementitious materials, as well as an overview of standardization of testing methods.

The versatile and available GNSS signals can detect the Earth's surface environments as a new, highly precise, continuous, all-weather and near-real-time remote sensing tool. This book presents the theory and methods of GNSS remote sensing as well as its applications in the atmosphere, oceans, land and hydrology. Ground-based atmospheric sensing, space-borne atmospheric sensing, reflectometry, ocean remote sensing, hydrology sensing as well as cryosphere sensing with the GNSS will be discussed per chapter in the book.

EPR of Free Radicals in Solids: Trends in Methods and Applications, 2nd ed. presents a critical two volume review of the methods and applications of EPR (ESR) for the study of free radical processes in solids. Emphasis is on the progress made in the developments in EPR technology, in the application of sophisticated matrix isolation techniques and in the advancement in quantitative EPR that have occurred since the 1st edition was published. Improvements have been made also at theoretical level, with the development of methods based on first principles and their application to the calculation of magnetic properties as well as in spectral simulations. EPR of Free Radicals in Solids II focuses on the trends in applications of experimental and theoretical methods to extract structural and dynamical properties of radicals and spin probes in solid matrices by continuous wave (CW) and pulsed techniques in nine chapters written by experts in the field. It examines the studies involving radiation- and photo-induced inorganic and organic radicals in inert matrices, the high-spin molecules and metal-based molecular clusters as well as the radical pro-cesses in photosynthesis. Recent advancements in environmental applications in-cluding measurements by myon resonance of radicals on surfaces and by quantitative EPR in dosimetry are outlined and the applications of optical detection in material research with much increased sensitivity reviewed. The potential use of EPR in quantum computing is considered in a newly written chapter. This new edition is aimed to experimentalists and theoreticians in research involving free radicals, as well as for students of advanced courses in physical chemis-try, chemical physics, materials science, biophysics, biochemistry and related fields.

This book examines non-invasive, electrical-based methods for disease diagnosis and assessment of heart function. In particular, a formalized signal model is proposed since this offers several advantages over methods that rely on measured data alone. By using a formalized representation, the parameters of the signal model can be easily manipulated and/or modified, thus providing mechanisms that allow researchers to reproduce and control such signals. In addition, having such a formalized signal model makes it possible to develop computer tools that can be used for manipulating and understanding how signal changes result from various heart conditions, as well as for generating input signals for experimenting with and evaluating the performance of e.g. signal extraction methods. The work focuses on bioelectrical information, particularly electrical bio-impedance (EBI). Once the EBI has been measured, the corresponding signals have to be modelled for analysis. This requires a structured approach in order to move from real measured data to the model of the corresponding signals. This book proposes a generic framework for this procedure. It can be used as a guide for modelling impedance cardiography (ICG) and impedance respirography (IRG) signals, as well as for developing the corresponding bio-impedance signal simulator (BISS).

Nature is characterized by a number of physical laws and fundamental dimensionless couplings. These determine the properties of our physical universe, from the size of atoms, cells and mountains to the ultimate fate of the universe as a whole. Yet it is rather remarkable how little we know about them. The constancy of physical laws is one of the cornerstones of the scientific research method, but for fundamental couplings this is an assumption with no other justification than a historical assumption. There is no 'theory of constants' describing their role in the underlying theories and how they relate to one another or how many of them are truly fundamental. Studying the behaviour of these quantities throughout the history of the universe is an effective way to probe fundamental physics. This explains why the ESA and ESO include varying fundamental constants among their key science drivers for the next generation of facilities. This symposium discussed the state-of-the-art in the field, as well as the key developments anticipated for the coming years.

This book provides a comprehensive introduction to X-ray and gamma-ray astronomy. The first part discusses the basic theoretical and observational topics related to black hole astrophysics; the optics and the detectors employed in X-ray and gamma-ray astronomy; and past, present, and future X-ray and gamma-ray missions. The second part then describes data reduction and analysis, the statistics used in X-ray and gamma-ray astronomy, and demonstrates how to write a successful proposal and a scientific paper. Data reduction in connection with specific X-ray and gamma-ray missions is covered in the appendices. Presenting the state of the art in X-ray and gamma-ray astronomy, this is both a valuable textbook for students and an important reference resource for researchers in the field.

This book presents high-performance data transmission over plastic optical fibers (POF) using integrated optical receivers having good properties with multilevel modulation, i.e. a higher sensitivity and higher data rate transmission over a longer plastic optical fiber length. Integrated optical receivers and transmitters with high linearity are introduced for multilevel communication. For binary high-data rate transmission over plastic optical fibers, an innovative receiver containing an equalizer is described leading also to a high performance of a plastic optical fiber link. The cheap standard PMMA SI-POF (step-index plastic optical fiber) has the lowest bandwidth and the highest attenuation among multimode fibers. This small bandwidth limits the maximum data rate which can be transmitted through plastic optical fibers. To overcome the problem of the plastic optical fibers high transmission loss, very sensitive receivers must be used to increase the transmitted length over POF. The plastic optical fiber limited bandwidth problem can be decreased by using multilevel signaling like multilevel pulse amplitude modulation or by using an equalizer for binary data transmission.

This book examines the most novel and state-of-the-art applications of biomaterials, with chapters that exemplify approaches with targeted drug delivery, diabetes, neurodegenerative diseases and cranioplasty implants. Expert contributors analyze biomaterials such as calcium phosphate, sol-gel and quenched glasses, metallic and polymer implants, bioactive glass, and polymer composites while also covering important areas such as the soft tissue replacement, apatites, bone regeneration and cell encapsulation. This book is appropriate for biomedical engineers, materials scientists, and clinicians who are seeking to implement the most advanced approaches and technologies with their patients.

This book provides the mathematical foundations of the theory of hyperhamiltonian dynamics, together with a discussion of physical applications. In addition, some open problems are discussed. Hyperhamiltonian mechanics represents a generalization of Hamiltonian mechanics, in which the role of the symplectic structure is taken by a hyperkahler one (thus there are three Kahler/symplectic forms satisfying quaternionic relations). This has proved to be of use in the description of physical systems with spin, including those which do not admit a Hamiltonian formulation. The book is the first monograph on the subject, which has previously been treated only in research papers.

Traditional research methodologies in the human respiratory system have always been challenging due to their invasive nature. Recent advances in medical imaging and computational fluid dynamics (CFD) have accelerated this research. This book compiles and details recent advances in the modelling of the respiratory system for researchers, engineers, scientists, and health practitioners. It breaks down the complexities of this field and provides both students and scientists with an introduction and starting point to the physiology of the respiratory system, fluid dynamics and advanced CFD modeling tools. In addition to a brief introduction to the physics of the respiratory system and an overview of computational methods, the book contains best-practice guidelines for establishing high-quality computational models and simulations. Inspiration for new simulations can be gained through innovative case studies as well as hands-on practice using pre-made computational code. Last but not least, students and researchers are presented the latest biomedical research activities, and the computational visualizations will enhance their understanding of physiological functions of the respiratory system.

"Advances in Imaging and Electron Physics "merges two long-running serials--"Advances in Electronics and Electron Physics" and "Advances in Optical and Electron Microscopy."
This series features extended articles on the physics of electron devices (especially semiconductor devices), particle optics at high and low energies, microlithography, image science and digital image processing, electromagnetic wave propagation, electron microscopy, and the computing methods used in all these domains.
* Contributions from leading international scholars and industry experts
* Discusses hot topic areas and presents current and future research trends
* Invaluable reference and guide for physicists, engineers and mathematicians