This book presents the novel formulation and development of a Stochastic Flood Forecasting System, using the Middle River Vistula basin in Poland as a case study. The system has a modular structure, including models describing the rainfall-runoff and snow-melt processes for tributary catchments and the transformation of a flood wave within the reach. The sensitivity and uncertainty analysis of the elements of the study system are performed at both the calibration and verification stages. The spatial and temporal variability of catchment land use and river flow regime based on analytical studies and measurements is presented. A lumped parameter approximation to the distributed modelling of river flow is developed for the purpose of flow forecasting. Control System based emulators (Hammerstein-Wiener models) are applied to on-line data assimilation. Medium-range probabilistic weather forecasts (ECMWF) and on-line observations of temperature, precipitation and water levels are used to prolong the forecast lead time. The potential end-users will also benefit from a description of social vulnerability to natural hazards in the study area.

To understand the global warming mechanism, global mapping of primary production was carried out under the GCMAPS program. The program was concerned with marine and terrestrial environmental changes, which affect carbon cycle on the regional and global scales. On the regional scale, warm phase of ENSO (El Nino / Southern Oscillation) has been shown to affect economic activities in many countries. The keyword for understanding mechanism of global warming is primary productivity . The earth observation satellites (EOS) like the ADEOS of Japan, and the SeaWiFS, Sea Star and Terra of the U.S.A. provided much required data for modeling and verification of primary production estimates on both land and ocean.
The knowledge gained during the GCMAPS program has been documented in this book. Interpretation of the data suggests that global warming, which causes temperature and sea level rise, and changes in climate and ecosystems, is likely to have the largest influence on mankind. The first half of this book discuss changes in marine environments. Physical and chemical oceanographic properties of the equatorial Pacific and Indian Oceans are presented. Changes in partial pressure of carbon dioxide, flux and composition of settling particles and biological communities in the surface ocean have also been discussed. In addition to this, over hundred years of environmental records based upon coral skeletons are presented. Estimations of primary production and its utilization in validating satellite imagery data were conducted in the western North Pacific. Primary productivity estimates based upon the validated satellite imagery are presented on the global scale. Climate change modeling of primary production in global oceans is also presented.
The latter half of this book deals with changes in terrestrial environments. Primary productivity estimates for different types of ecosystems (e.g., forest, grassland) are presented together with soil carbon dynamics. Also, biomass and productivity estimation and environmental monitoring based upon remote sensing techniques are presented with a model analysis of the relationship between climate perturbations and carbon budget anomalies in global terrestrial ecosystems. This book elucidates integrated aspects of the global carbon cycle involving marine and terrestrial environments.
* Discusses a current understanding of the biogeochemical processes on land and ocean
* Provides global mapping of primary production based on satellite imagery data and modeling
* Presents the latest interpretations of relationships between carbon cycle and climatic change"

This text provides the reader with a comprehensive understanding of the key ideas behind the physics of particle accelerators. Supported by a clear mathematical treatment and a range of calculations which develop a genuine feeling for the subject, it is a thorough introduction to the many aspects of accelerator physics.

Since the use of high-precision/resolution spectroscopy is closely connected to the ability to collect a large number of photons, the scientific domains using this technique benefit tremendously from the use of 8-meter class telescopes and will fully exploit the tremendous gain provided by future Extremely Large Telescopes (ELTs). This volume comprehensively covers the astrophysical and technical aspects of high-precision spectroscopy with an outlook to future developments.

The Earth's average temperature has risen by 1.4 DegreesF over the past century, and computer models project that it will rise much more over the next hundred years, with significant impacts on weather, climate, and human society. Many climate scientists attribute these increases to the build up of greenhouse gases produced by the burning of fossil fuels and to the anthropogenic production of short-lived climate pollutants. Climate Change Modeling Methodologies: Selected Entries from the Encyclopaedia of Sustainability Science and Technology provides readers with an introduction to the tools and analysis techniques used by climate change scientists to interpret the role of these forcing agents on climate. Readers will also gain a deeper understanding of the strengths and weaknesses of these models and how to test and assess them. The contributions include a glossary of key terms and a concise definition of the subject for each topic, as well as recommendations for sources of more detailed information.

The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. Volume 5 is devoted to cells, tissues, and organs of the cardiovascular and ventilatory systems with an emphasis on mechanotransduction-based regulation of flow. The blood vessel wall is a living tissue that quickly reacts to loads applied on it by the flowing blood. In any segment of a blood vessel, the endothelial and smooth muscle cells can sense unusual time variations in small-magnitude wall shear stress and large-amplitude wall stretch generated by abnormal hemodynamic stresses. These cells respond with a short-time scale (from seconds to hours) to adapt the vessel caliber. Since such adaptive cell activities can be described using mathematical models, a key objective of this volume is to identify the mesoscopic agents and nanoscopic mediators required to derive adequate mathematical models. The resulting biomathematical models and corresponding simulation software can be incorporated into platforms developed in virtual physiology for improved understanding and training.

Disulfide-containing proteins belong to a unique class of proteins for studying the mechanism of protein folding. Their folding mechanism can be analyzed by three distinct techniques: (1) The conventional denaturation-renaturation method (disulfide intact); (2) The disulfide oxidation method (oxidative folding); and (3) The emerging disulfide scrambling method. Each technique provides specific information as to how an unfolded disulfide protein refolds to form the native structure. This book is intended to highlight the knowledge of several important proteins (BPTI, RNase A, beta-Lactalbumin and Lysozyme etc.) that have been characterized in depth by these methodologies. The book will also devote sections to comparing these methodologies and chaperones (PDI and Dsb machineries) that facilitate folding of disulfide proteins. Folding of Disulfide Proteins aims to cover the knowledge of protein folding accumulated from studies of disulfide-containing proteins, including methodologies, folding pathways, and folding mechanism of numerous extensively characterized disulfide proteins. This book will be of interest to those interested in problems related to protein folding, and anyone who is interested in understanding the mechanism of protein misfolding and protein misfolding-related diseases. Folding of Disulfide Proteins aims to cover the knowledge of protein folding accumulated from studies of disulfide-containing proteins, including methodologies, folding pathways, and folding mechanism of numerous extensively characterized disulfide proteins. This book will be of interest to those interested in problems related to protein folding, and anyone who is interested in understanding the mechanism of protein misfolding and protein misfolding-related diseases.

This book reviews the phenomenology displayed by relativistic jets as well as the most recent theoretical efforts to understand the physical mechanisms at their origin. Relativistic jets have been observed and studied in Active Galactic Nuclei (AGN) for about half a century and are believed to be fueled by accretion onto a supermassive black hole at the center of the host galaxy. Since the first discovery of relativistic jets associated with so-called "micro-quasars" much more recently, it has seemed clear that much of the physics governing the relativistic outflows in stellar X-ray binaries harboring black holes and in AGN must be common, but acting on very different spatial and temporal scales. With new observational and theoretical results piling up every day, this book attempts to synthesize a consistent, unified physical picture of the formation and disruption of jets in accreting black-hole systems. The chapters in this book offer overviews accessible not only to specialists but also to graduate students and astrophysicists working in other areas. Covered topics comprise Relativistic jets in stellar systems Launching of AGN jets Parsec-scale AGN jets Kiloparsec-scale AGN jets Black hole magnetospheres Theory of relativistic jets The structure and dynamics of the inner accretion disk The origin of the jet magnetic field X-ray observations, phenomenology, and connection with theory

This volume provides a comprehensive selection of recent studies addressing insect hearing and acoustic communication. The variety of signalling behaviours and hearing organs makes insects highly suitable animals for exploring and analysing signal generation and hearing in the context of neural processing, ecology, evolution and genetics. Across a variety of hearing species like moths, crickets, bush-crickets, grasshoppers, cicadas and flies, the leading researchers in the field cover recent scientific progress and address key points in current research, such as:

. How can we approach the evolution of hearing in insects and what is the developmental and neural origin of the auditory organs?

. How are hearing and sound production embedded in the natural lifestyle of the animals, allowing intraspecific communication but also predator avoidance and even predation?

. What are the functional properties of hearing organs and how are they achieved at the molecular, biophysical and neural levels?

. What are the neural mechanisms of central auditory processing and signal generation?

The book is intended for students and researchers both inside and outside of the fascinating field of bioacoustics and aims to foster understanding of hearing and acoustic communication in insects."

Understanding the stars is the bedrock of modern astrophysics. Stars are the source of life. The chemical enrichment of our Milky Way and of the Universe withallelementsheavierthanlithiumoriginatesintheinteriorsofstars.Stars arethe tracersofthe dynamics ofthe Universe,gravitationallyimplying much more than meets the eye. Stars ionize the interstellar medium and re-ionized the early intergalactic medium. Understanding stellar structure and evolution is fundamental. While stellar structure and evolution are understood in general terms, we lack important physical ingredients, despite extensive research during recent decades.Classicalspectroscopy,photometry,astrometryandinterferometryof stars have traditionally been used as observational constraints to deduce the internal stellar physics. Unfortunately, these types of observations only allow the tuning of the basic common physics laws under stellar conditions with relatively poor precision. The situation is even more worrisome for unknown aspects of the physics and dynamics in stars. These are usually dealt with by using parameterised descriptions of, e.g., the treatments of convection, rotation,angularmomentumtransport,theequationofstate,atomicdi?usion andsettlingofelements,magneto-hydrodynamicalprocesses,andmore.There is a dearth of observational constraints on these processes, thus solar values areoftenassignedtothem.Yetitishardtoimaginethatonesetofparameters is appropriate for the vast range of stars.

The years 2012/2013 mark the 50th anniversary of the theoretical prediction that Brown Dwarfs, i.e. degenerate objects which are just not massive enough to sustain stable hydrogen fusion, exist. Some 20 years after their discovery, how Brown Dwarfs form is still one of the main open questions in the theory of star formation. In this volume, the pioneers of Brown Dwarf research review the history of the theoretical prediction and the subsequent discovery of Brown Dwarfs. After an introduction, written by Viki Joergens, reviewing Shiv Kumar's theoretical prediction of the existence of brown dwarfs, Takenori Nakano reviews his and Hayashi's calculation of the Hydrogen Burning Minimum Mass. Both predictions happened in the early 1960s. Jill Tarter then writes on the introduction of the term 'Brown Dwarf', before Ben Oppenheimer, Rafael Rebolo and Gibor Basri describe their first discovery of Brown Dwarfs in the 1990s. Lastly, Michael Cushing and Isabelle Baraffe describe the development of the field to the current state of the art. While the book is mainly aimed at the Brown Dwarf research community, the description of the pioneering period in a scientific field will attract general readers interested in astronomy as well.

For some time immunotherapy has been heralded as a breakthrough approach for cancer treatment. Although the potential of this strategy remains solid, the approach needs considerable refinement. Whilst some programmes are looking to increase the understanding of molecular and cellular mechanisms underlying the stimulation of antitumor immunity, others are trying to find the most appropriate clinical setting that will reveal the role of the immune system in combating cancer. Among the most important discoveries have been tumor-specific antigens.
This thematic volume highlights some key issues and discusses where they may move forward. It has been put together by two leading cancer immunotherapists from two eminent institutions that focus on cancer research.

Availability of advanced computational technology has fundamentally altered the investigative paradigm in the field of biomechanics. Armed with sophisticated computational tools, researchers are seeking answers to fundamental questions by exploring complex biomechanical phenomena at the molecular, cellular, tissue and organ levels. The computational armamentarium includes such diverse tools as the ab initio quantum mechanical and molecular dynamics methods at the atomistic scales and the finite element, boundary element, meshfree as well as immersed boundary and lattice-Boltzmann methods at the continuum scales. Multiscale methods that link various scales are also being developed. While most applications require forward analysis, e.g., finding deformations and stresses as a result of loading, others involve determination of constitutive parameters based on tissue imaging and inverse analysis. This book provides a glimpse of the diverse and important roles that modern computational technology is playing in various areas of biomechanics including biofluids and mass transfer, cardiovascular mechanics, musculoskeletal mechanics, soft tissue mechanics, and biomolecular mechanics.

This book concisely expounds the fundamental concepts, phenomena, theories and procedures in a complete and systematic sense. In this book, not only almost all the important achievements from predecessors but also the contributions from the author himself have been summed up profoundly. Starting from the derivation of fundamental equations, various classical acoustical phenomena such as reflection, refraction, scattering diffraction and absorption in atmosphere, as well as the influences of gravitation and rotation of the earth on the behaviors of different atmospheric waves including acoustic waves, have been discussed in viewpoints of wave acoustics and geometrical acoustics respectively. The recent developments of several computation methods in the field of atmospheric acoustics have been introduced in some detail. As for the application aspects, atmospheric remote sensing has been discussed from the angle of inverse problems.

In early April 1911 Albert Einstein arrived in Prague to become full professor of theoretical physics at the German part of Charles University. It was there, for the first time, that he concentrated primarily on the problem of gravitation. Before he left Prague in July 1912 he had submitted the paper Relativitat und Gravitation: Erwiderung auf eine Bemerkung von M. Abraham in which he remarkably anticipated what a future theory of gravity should look like.

At the occasion of the Einstein-in-Prague centenary an international meeting was organized under a title inspired by Einstein's last paper from the Prague period: "Relativity and Gravitation, 100 Years after Einstein in Prague." The main topics of the conference included: classical relativity, numerical relativity, relativistic astrophysics and cosmology, quantum gravity, experimental aspects of gravitation and conceptual and historical issues.

The conference attracted over 200 scientists from 31 countries, among them a number of leading experts in the field of general relativity and its applications. This volume includes abstracts of the plenary talks and full texts of contributed talks and articles based on the posters presented at the conference. These describe primarily original results of the authors. Full texts of the plenary talks are included in the volume "General Relativity, Cosmology and Astrophysics--Perspectives 100 Years after Einstein in Prague," eds. J. Bi ak and T. Ledvinka, published also by Springer Verlag."

This book contains a collection of papers that were presented at the IUTAM Symposium on "Computer Models in Biomechanics: From Nano to Macro" held at Stanford University, California, USA, from August 29 to September 2, 2011. It contains state-of-the-art papers on: - Protein and Cell Mechanics: coarse-grained model for unfolded proteins, collagen-proteoglycan structural interactions in the cornea, simulations of cell behavior on substrates - Muscle Mechanics: modeling approaches for Ca2+-regulated smooth muscle contraction, smooth muscle modeling using continuum thermodynamical frameworks, cross-bridge model describing the mechanoenergetics of actomyosin interaction, multiscale skeletal muscle modeling - Cardiovascular Mechanics: multiscale modeling of arterial adaptations by incorporating molecular mechanisms, cardiovascular tissue damage, dissection properties of aortic aneurysms, intracranial aneurysms, electromechanics of the heart, hemodynamic alterations associated with arterial remodeling following aortic coarctation, patient-specific surgery planning for the Fontan procedure - Multiphasic Models: solutes in hydrated biological tissues, reformulation of mixture theory-based poroelasticity for interstitial tissue growth, tumor therapies of brain tissue, remodeling of microcirculation in liver lobes, reactions, mass transport and mechanics of tumor growth, water transport modeling in the brain, crack modeling of swelling porous media - Morphogenesis, Biological Tissues and Organs: mechanisms of brain morphogenesis, micromechanical modeling of anterior cruciate ligaments, mechanical characterization of the human liver, in vivo validation of predictive models for bone remodeling and mechanobiology, bridging scales in respiratory mechanics

This book provides a challenging and stimulating introduction to the contemporary topics of complexity and criticality, and explores their common basis of scale invariance, a central unifying theme of the book.Criticality refers to the behaviour of extended systems at a phase transition where scale invariance prevails. The many constituent microscopic parts bring about macroscopic phenomena that cannot be understood by considering a single part alone. The phenomenology of phase transitions is introduced by considering percolation, a simple model with a purely geometrical phase transition, thus enabling the reader to become intuitively familiar with concepts such as scale invariance and renormalisation. The Ising model is then introduced, which captures a thermodynamic phase transition from a disordered to an ordered system as the temperature is lowered in zero external field. By emphasising analogies between percolation and the Ising model, the reader's intuition of phase transitions is developed so that the underlying theoretical formalism may be appreciated fully. These equilibrium systems undergo a phase transition only if an external agent finely tunes certain external parameters to particular values.Besides fractals and phase transitions, there are many examples in Nature of the emergence of such complex behaviour in slowly driven non-equilibrium systems: earthquakes in seismic systems, avalanches in granular media and rainfall in the atmosphere. A class of non-equilibrium systems, not constrained by having to tune external parameters to obtain critical behaviour, is addressed in the framework of simple models, revealing that the repeated application of simple rules may spontaneously give rise to emergent complex behaviour not encoded in the rules themselves. The common basis of complexity and criticality is identified and applied to a range of non-equilibrium systems. Finally, the reader is invited to speculate whether self-organisation in non-equilibrium systems might be a unifying concept for disparate fields such as statistical mechanics, geophysics and atmospheric physics.Visit for animations for the models in the book (available for Windows and Linux), solutions to exercises, as well as a list with corrections.

It is over a quarter of a century since the discovery of out?ows from young stars. The intervening years have led to remarkable advances in our understanding of this phenomenon. Much of the progress can be attributed to advances in facilities and technologies, including not only larger telescopes but also improved instrument and detector performance. In addition protostellar out?ows have now been imaged from the ground and space at high spatial resolution, e. g. with HST, and at a wide - riety of wavelengths from X-rays to radio waves, revealing more and more about their physics. This veritable revolution in observation has been accompanied by an exponential growth in our ability to numerically simulate the launching and pro- gation of jets. Codes continue to improve: they now incorporate more physics and are increasingly ef?cient through, for example, techniques such as adaptive mesh re?nement and the use of parallel processing in cluster environments. Simulating the launching and propagation of a jet all the way from the vicinity of the star up to 4 several thousand AU (a size range of10 ) is now much closer. In more recent times, developments in observation, theory and numerical s- ulation have been joined by laboratory jet experiments reproducing, on centimetre scales, that which is seen in astrophysics to stretch for several parsecs.

Lightning represents a natural phenomenon of substantial interest. Due to its complex nature, research continues in many countries and reveals amazing results. Lightning is actively observed because of its relevance to Earth climate and air composition in addition to the classical aspects of related human fatalities and damage to forests, buildings, power lines, aircraft, structures and electronic devices. In this volume, the most important contemporary questions on lightning are addressed and analyzed under many experimental and theoretical aspects. Lightning detection techniques using ground-based and space-borne methods are described, along with network engineering and statistical analysis. Contributions detail research on atmospheric electricity, cloud physics, lightning physics, modeling of electrical storms and middle atmospheric events. Special phenomena such as triggered lightning and sprite observations are examined. Lightning-induced nitrogen oxides and their effects on atmospheric chemistry and climate are discussed. Each topic is presented by international experts in the field. Topics include: * air chemistry * convective storms * infrasound from lightning * lightning and climate change * lightning and precipitation * lightning and radiation * lightning and supercells * lightning and thunderstorms * lightning detection * lightning from space * lighting protection * lightning return strokes * observations and interpretations * spatial distribution and frequency * triggered lightning * weather extremes

This book focuses on the application of fluorescence to study motor proteins (myosins, kinesins, DNA helicases and RNA polymerases). It is intended for a large community of biochemists, biophysicists and cell biologists who study a diverse collection of motor proteins. It can be used by researchers to gain an insight into their first experiments, or by experienced researchers who are looking to expand their research to new areas. Each chapter provides valuable advice for executing the experiments, along with detailed background knowledge in order to develop own experiments.

Mars, the most habitable of our sister planets, holds a special place in our imaginations and in our space exploration program. Fully half of NASA's planetary exploration effort is now devoted to Mars. Key questions include: Has Mars ever harbored life? Is there life on Mars now? Will humans be able to survive on the Martian surface? Answers to these questions lie in determining the present location of water on Mars and its likely inventory in the past, and in determining the present radiation environment of Mars. The 2001 Mars Odyssey Mission contributes greatly these answers by detecting near-surface water through measurements of neutron flux, from the detection of carbonates, and the quantification of its radiation environment. This book captures the objectives, the design of the mission and the details of the instruments carried to Mars. It should be of interest to every scientist interested in participating in the on-going exploration of Mars from graduate students to senior scientists as it provides the background information essential to interpret the many exciting results now appearing from the mission.