This volume, written by experts in the field, discusses the current understanding of the biophysical principles that govern RNA folding, with featured RNAs including the ribosomal RNAs, viral RNAs, and self-splicing introns. In addition to the fundamental features of RNA folding, the central experimental and computational approaches in the field are presented with an emphasis on their individual strengths and limitations, and how they can be combined to be more powerful than any method alone; these approaches include NMR, single molecule fluorescence, site-directed spin labeling, structure mapping, comparative sequence analysis, graph theory, course - grained 3D modeling, and more. This volume will be of interest to professional researchers and advanced students entering the field of RNA folding.

This book provides an up-to-date understanding of the progress and current problems of the interplay of nonlocality in the classical theories of gravitation and quantum theory. These problems lie on the border between general relativity and quantum physics, including quantum gravity.

Jean-Pierre Vigier continually labeled one of les heretiques de la science, l'eternel resistant et le patriarche is yet a pillar of modern physics and mathematics, with one leg firmly planted in theory and the other in empiricism spanning a career of nearly 60 years with a publication vitae quickly approaching 400! He wrote of his mentor Louis de Broglie "Great physicists fight great battles", which perhaps applies even more so to 1 Jean-Pierre Vigier himself . If fortune allows a visit to Paris, reported to be the city of love, and certainly one of the most beautiful and interesting cities in the world; one has been treated to a visual and cultural feast. For example a leisurely stroll from the Musee du Louvre along the Champs-Elysees to the Arc de Triomphe would instill even the least creative soul with the entelechies of a poets muse. It is perhaps open to theoretical interpretation, but if causal conditions have allowed one to be a physicist, visiting Paris, one may have taken opportunity to visit the portion of the old Latin quarter in place Jussieu where Pierre et Marie Curie Universite, reported to be 'the best university in France', is stationed.

Quantum mechanics is widely recognized as the basic law which governs all of nature, including all materials and devices. It has always been essential to the understanding of material properties, and as devices become smaller it is also essential for studying their behavior. Nevertheless, only a small fraction of graduate engineers and materials scientists take a course giving a systematic presentation of the subject. The courses for physics students tend to focus on the fundamentals and formal background, rather than on application, and do not fill the need. This invaluable text has been designed to fill the very apparent gap.The book covers those parts of quantum theory which may be necessary for a modern engineer. It focuses on the approximations and concepts which allow estimates of the entire range of properties of nuclei, atoms, molecules, and solids, as well as the behavior of lasers and other quantum-optic devices. It may well prove useful also to graduate students in physics, whose courses on quantum theory tend not to include any of these applications. The material has been the basis of a course taught to graduate engineering students for the past four years at Stanford University.Topics Discussed: Foundations; Simple Systems; Hamiltonian Mechanics; Atoms and Nuclei; Molecules; Crystals; Transitions; Tunneling; Transition Rates; Statistical Mechanics; Transport; Noise; Energy Bands; Electron Dynamics in Solids; Vibrations in Solids; Creation and Annihilation Operators; Phonons; Photons and Lasers; Coherent States; Coulomb Effects; Cooperative Phenomena; Magnetism; Shake-off Excitations; Exercise Problems.A supplementary Instructor's Solutions Manual is available for this book.

Silicon, the basic material for a multibillion-dollar industry, is the most widely researched and applied semiconductor, and its surfaces are the most thoroughly studied of all semiconductor surfaces. Silicon Surfaces and Formation of Interfaces may be used as an introduction to graduate-level physics and chemical physics. Moreover, it gives a specialized and comprehensive description of the most common faces of silicon crystals as well as their interaction with adsorbates and overlayers. This knowledge is presented in a systematic and easy-to-follow way. Discussion of each system is preceded by a brief overview which categorizes the features and physical mechanisms before the details are presented. The literature is easily available, and the references am numerous and organized in tables, allowing a search without the need to browse through the text.

Though this volume focuses on a scientific understanding of physics on the atomistic and mesoscopic levels, it also highlights existing and potential links between basic research in surface science and applications in the silicon industry. It will be valuable to anyone writing a paper, thesis, or proposal in the field of silicon surfaces.

This volume is one outcome of the 6th International Conference on Paleoceano graphy (ICP VI). The conference was held August 23-28, 1998 in Lisbon, Portugal. The meeting followed the traditional format of a small number of invited oral presentations complemented by a large number ofcontributed posters. Over 550 participants attended, representing thirty countries and nearly 450 posters were presented. The invited speakers addressed the main themes of the 5oral sessions. The session topics were: Polar-Tropical and Interhemisphere Linkages; Does the Ocean Cause, or Respond to, Abrupt Climatic Changes?; Biotic Responses to Major Paleoceanographic Changes; Past Warm Climates; and Innovations In Monitoring Ocean History. This is the first time in ICP history that the Conference Proceedings are published. The aim of the organisers with the publication of this book is two-fold: to provide a useful review of the field and to document the ideas/controversies raised during the con ference that may stimulate future work. The book reflects the initial intentions of the conference, but it is not a conven tional conference proceedings, given that the papers have been reviewed by formal exter nal referees. Each of the conference topics is introduced by a review article designed to summarize the state of the art in each theme followed by articles prepared by the invited speakers. As with most conference proceedings, each theme is covered heterogenously. Some topics have all the expected contributions, others are less well covered."

The PUILS series delivers up-to-date reviews of progress in Ultrafast Intense Laser Science, a newly emerging interdisciplinary research field spanning atomic and molecular physics, molecular science, and optical science, which has been stimulated by the recent developments in ultrafast laser technologies. Each volume compiles peer-reviewed articles authored by researchers at the forefront of each their own subfields of UILS. Every chapter opens with an overview of the topics to be discussed, so that researchers unfamiliar to the subfield, as well as graduate students, can grasp the importance and attractions of the research topic at hand; these are followed by reports of cutting-edge discoveries. This ninth volume covers a broad range of topics from this interdisciplinary research field, focusing on ultrafast molecular responses to an intense laser field, advanced techniques for attosecond pulse generation, atomic and molecular responses to attosecond pulses, photoelectron spectroscopy of atoms and molecules interacting with intense light fields, and attosecond pulse interaction with solid materials.

Ring polymers are one of the last big mysteries in polymer physics, and this thesis tackles the problem of describing their behaviour when interacting in dense solutions and with complex environments and reports key findings that help shed light on these complex issues. The systems investigated are not restricted to artificial polymer systems, but also cover biologically inspired ensembles, contributing to the broad applicability and interest of the conclusions reached. One of the most remarkable findings is the unambiguous evidence that rings inter-penetrate when in dense solutions; here this behaviour is shown to lead to the emergence of a glassy state solely driven by the topology of the constituents. This novel glassy state is unconventional in its nature and, thanks to its universal properties inherited from polymer physics, will attract the attention of a wide range of physicists in the years to come.

This new fourth edition of Allen's classic Astrophysical Quantities belongs on every astronomer's bookshelf. It has been thoroughly revised and brought up to date by a team of more than ninety internationally renowned astronomers and astrophysicists. While it follows the basic format of the original, this indispensable reference has grown to more than twice the size of the earlier editions to accommodate the great strides made in astronomy and astrophysics. It includes detailed tables of the most recent data on: - General constants and units - Atoms, molecules, and spectra - Observational astronomy at all wavelengths from radio to gamma-rays, and neutrinos - Planetary astronomy: Earth, planets and satellites, and solar system small bodies - The Sun, normal stars, and stars with special characteristics - Stellar populations - Cataclysmic and symbiotic variables, supernovae - Theoretical stellar evolution - Circumstellar and interstellar material - Star clusters, galaxies, quasars, and active galactic nuclei - Clusters and groups of galaxies - Cosmology. As well as much explanatory material and extensive and up-to-date bibliographies. The CD-ROM contains the full text of the book as a searchable PDF file.

This volume describes and discusses recent advances in angiogenesis research. The chapters are organized to address all biological length scales of angiogenesis: molecular, cellular and tissue in both in vivo and in vitro settings. Specific emphasis is given to novel methodologies and biomaterials that have been developed and applied to angiogenesis research. Angiogenesis experts from diverse fields including engineering, cell and developmental biology, chemistry and physics will be invited to contribute chapters which focus on the mechanical and chemical signals which affect and promote angiogenesis.

This book is a continuation of 'Acoustic and Elastic Wave Fields in Geophysics, Part I' published in 2000. The second volume is dedicated to propagation of linear plane, spherical and cylindrical acoustic waves in different media. Chapter 1 is devoted to principles of geometric acoustic in plane wave approximation. The eikonal and transport equations are derived. Ray tracing and wavefront construction techniques are explained. Chapter 2 deals with dynamic properties of wave fields. The behavior of pressure and displacements amplitudes in zero approximation is analysed in two ways: using Poynting vector and solving the transport equation. This chapter contains several examples related to shadow zones and caustics. In Chapter 3 using the results of analysis of high-frequency wave kinematics and dynamics some fundamental aspects of Kirchhoff migration are described. Chapters 4 and 5 are devoted to propagation of plane waves in media with flat boundaries in the case of normal and oblique incidence. Special attention is paid to the case when an incident angle exceeds the critical angles. Formation of normal modes in the waveguide is discussed. Chapter 6 deals with a spherical wave reflection and refraction. The steepest descent method is introduced to describe the behavior of reflected, transmitted, head and evanescent waves. In Chapter 7 propagation of stationary and transient waves in a waveguide formed by a flat layer with low velocity are investigated. Normal modes and waves related to the branch points of integrands under consideration are studied. Dispersive properties of normal modes are discussed. Chapter 8 describes wave propagation inside cylinder in acoustic media. Several appendices are added to help the reader understand different aspects of mathematics used in the book.

Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies.
Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered.
This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology.
Key Features
* Introduces the relevant aspects of molecular biology and biophysics
* Describes the principal methods used to study channelopathies
* Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function
* Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype

Sodium reabsorbing epithelia play a major role in whole-body sodium homeostasis. Some examples of sodium regulating tissues include kidney, colon, lung, and sweat ducts. Sodium transport across these membranes is a two-step process: entry through an amiloride-sensitive sodium channel and exit via the ouabain-sensitive sodium/potassium ATPase. The sodium entry channels are the rate-limiting determinant for transport and are regulated by several different hormones. The sodium channels also play a significant role in a number of disease states, like hypertension, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity provides the first in-depth exchange of ideas concerning these sodium channels, their regulation and involvement in normal and pathophysiological situations.
Key Features
* Summarizes current state of amiloride-sensitive sodium channel field
* Analyzes structure-function of epithelial sodium channels
* Discusses immunolocalization of epithelial sodium channels
* Examines hormonal regulation of sodium channels
* Discusses sodium channels in lymphocytes, kidney, and lung
* Considers mechanosensitivity of sodium channels
* Provides ideas on sodium channels and disease

The study of the mechanisms that govern origin and propagation of stellar jets involves the treatment of many concurrent physical processes such as gravitation, hydrodynamics and magnetohydrodynamics, atomic physics and radiation. In the past years, an intensive work has been done looking for so- tions of the ideal MHD equations in the steady state limit as well as studying the stability of out?ows in the linear regime. These kind, of approaches have provided a contribution to the understanding of jets that can hardly be ov- estimated. However, the extension of the analyses to the time-dependent and nonlinear regimes could not be avoided, and the MHD numerical simulations were the only mean to achieve this goal. Intherecentyears,considerableprogresseshavebeenmadebythecom- tational?uiddynamiccommunityinthedevelopmentofnumericaltechniques, theso-calledhighresolutionshockcapturingschemes,wellsuitedforthetre- ment of supersonic ?ows with discontinuities. The numerical simulations of astrophysical jets took advantage of these developments; however new physics needed to be incorporated, such as magnetic ?eld e?ects, radiation losses by diluted gases, and proper astrophysics environments. These needs led to the nontrivial extension of the methods devised for the Euler equations of g- dynamics to the magneto-hydrodynamical system. On the other hand, the possibility of carrying out numerical calculations has been greatly facilitated bytheavailability, ononehand,ofpowerfulsupercomputersand,ontheother hand, of fast processors at low cost. Large scale 3D simulations of jets at high resolution are now possible thanks to supercomputers, but also high reso- tion 2D MHD simulations can be performed routinely on desktop computers.

This book provides a coherent and comprehensive overview of the generation and application of mono-energetic positron beams. It has been written by acknowledged experts, at a level accessible to graduate students working, or planning to work, with positron beams, and to scientists in other areas who want to know something about the field.

The book begins with a brief historical introduction and an overview of how positron beams are generated and transported. A description of the fate of slow positrons in gaseous and condensed matter, with reference to many of the fundamental measurements made possible by the advent of positron beams, is followed by a discussion on applications in the study of solid surfaces, defect profiling in subsurface regions, interfaces and thin films, and the probing of bulk properties in novel ways. The book ends with a look at the future, considering the prospects for intense positron beams and their potential for further research.

This thesis presents a novel single-molecule spectroscopy method that, for the first time, allows the dipole orientations and fluorescence lifetimes of individual molecules to be measured simultaneously. These two parameters are needed to determine the position of individual molecules with nanometer accuracy near a metallic structure. Proof-of-principle experiments demonstrating the value of this new single-molecule localization concept are also presented. Lastly, the book highlights potential applications of the method in biophysics, molecular physics, soft matter and structural biology.

Since the invention of the first laser 30 years ago, the frequency conversion of laser radiation in nonlinear optical crystals has become an important technique widely used in quantum electronics and laser physics for solving various scientific and engineering problems. The fundamental physics of three-wave light interactions in nonlinear optical crystals is now well understood. This has enabled the production of various harmonic generators, sum-and difference frequency generators, and optical parametric oscillators based on nonlinear optical crystals that are now commercially available. At the same time, scientists continue an active search for novel, highly efficient nonlinear optical materials. Therefore, in our opinion, there is a great need for a handbook of nonlinear optical crystals, intended for specialists and practitioners with an engineering background. This book contains a complete description of the properties and applications of all nonliner optical crystals of practical importance reported in the literature up to the beginning of 1990. In addition, it contains the most important equations for calculating the main parameters (such as phase-matching direction, effective nonlinearity, and conversion efficiency) of nonlinear frequency converters. Dolgoprudnyi, Yerevan, Troitzk v. G. Dmitriev USSR G. G. Gurzadyan October 1990 D. N. Nikogosyan Contents 1 Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Optics of Nonlinear Crystals. . . . . . . . . . . . . . . . . . . . . . . . 3 . . . . . ."

This handbook is a compendium giving a comprehensive description of the basics of semiconductor physics relevant to the design and analysis of thin film solar cell materials. It starts from the basics of material science, describing the material and its growth, defect and electrical properties, the basics of its interaction with photons and the involved statistics, proceeding to space charge effects in semiconductors and pn-junctions. Most attention is given to analyze homo- and hetero-junction solar cells using various models and applying the field-of-direction analysis for discussing current voltage characteristics, and helping to discover the involvement of high-field effects in solar cells. The comprehensive coverage of the main topics of - and relating to - solar cells with extensive reference to literature helps scientists and engineers at all levels to reach a better understanding and improvement of solar cell properties and their production. The author is one of the founders of thin film solar cell research.

In seismology an earthquake source is described in terms of a fault with a particular rupture size. The faulting process of large earthquakes has been investigated in the last two decades through analyses of long-period seismo grams produced by advanced digital seismometry. By long-period far-field approximation, the earthquake source has been represented by physical parameters such as s ismic moment, fault dimension and earthquake mag nitude. Meanwhile, destruction often results from strong ground motion due to large earthquakes at short distances. Since periods of strong ground motion are far shorter than those of seismic waves at teleseismic distances, the theory of long-period source process of earthquakes cannot be applied directly to strong ground motion at short distances. The excitation and propagation of high-frequency seismic waves are of special interest in recent earthquake seismology. In particular, the descrip tion and simulation of strong ground motion are very important not only for problems directly relevant to earthquake engineering, but also to the frac ture mechanics of earthquake faulting. Understanding of earthquake sources has been developed by investigating the complexity of faulting processes for the case of large earthquakes. Laboratory results on rock failures have also advanced the understanding of faulting mechanisms. Various attempts have been made to simulate, theoretically and empirically, the propagation of short-period seismic waves in the heterogeneous real earth."

The articles included in this Volume represent a broad and highly qualified view on the present state of general relativity, quantum gravity, and their cosmological and astrophysical implications. As such, it may serve as a valuable source of knowledge and inspiration for experts in these fields, as well as an advanced source of information for young researchers.
The occasion to gather together so many leading experts in the field was to celebrate the centenary of Einstein's stay in Prague in 1911-1912. It was in fact during his stay in Prague that Einstein started in earnest to develop his ideas about general relativity that fully developed in his paper in 1915.
Approaching soon the centenary of his famous paper, this volume offers a precious overview of the path done by the scientific community in this intriguing and vibrant field in the last century, defining the challenges of the next 100 years.
The content is divided into four broad parts: (i) Gravity and Prague, (ii) Classical General Relativity, (iii) Cosmology and Quantum Gravity, and (iv) Numerical Relativity and Relativistic Astrophysics.

In this thesis, the author investigates the biophysical basis of the local field potential (LFP) as a way of gaining a better understanding of its underlying physiological mechanisms. The results represent major advances in our understanding and interpretation of LFPs and brain oscillations. They highlight the importance of using suitable experimental and analytical methods to explore the activity of brain circuits and point to the LFP as a useful, but complex variable for this purpose.

This 6th edition of "Tools of Radio Astronomy", the most used introductory text in radio astronomy, has been revised to reflect the current state of this important branch of astronomy. This includes the use of satellites, low radio frequencies, the millimeter/sub-mm universe, the Cosmic Microwave Background and the increased importance of mm/sub-mm dust emission. Several derivations and presentations of technical aspects of radio astronomy and receivers, such as receiver noise, the Hertz dipole and beam forming have been updated, expanded, re-worked or complemented by alternative derivations. These reflect advances in technology. The wider bandwidths of the Jansky-VLA and long wave arrays such as LOFAR and mm/sub-mm arrays such as ALMA required an expansion of the discussion of interferometers and aperture synthesis. Developments in data reduction algorithms have been included. As a result of the large amount of data collected in the past 20 years, the discussion of solar system radio astronomy, dust emission, and radio supernovae has been revisited. The chapters on spectral line emission have been updated to cover measurements of the neutral hydrogen radiation from the early universe as well as measurements with new facilities. Similarly the discussion of molecules in interstellar space has been expanded to include the molecular and dust emission from protostars and very cold regions. Several worked examples have been added in the areas of fundamental physics, such as pulsars. Both students and practicing astronomers will appreciate this new up-to-date edition of Tools of Radio Astronomy.

This book provides an in-depth treatment of both linear fiber-optic systems and their key enabling devices. It presents a concise but rigorous treatment of the theory and practice of analog (linear) fiber-optics links and systems that constitute the foundation of Hybrid Fiber Coax infrastructure in present-day CATV distribution and cable modem Internet access. Emerging applications in remote fiber-optic feed for free-space millimeter wave enterprise campus networks are also described. Issues such as dispersion and interferometric noise are treated quantitatively, and means for mitigating them are explained. This broad but concise text will thus be invaluable not only to students of fiber-optics communication but also to practicing engineers. To the second edition of this book important new aspects of linear fiber-optic transmission technologies are added, such as high level system architectural issues, algorithms for deriving the optimal frequency assignment, directly modulated or externally modulated laser transmitters and the use of Erbium-doped fiber amplifier (EDFA) in linear fiber optic systems. Significant examples of field deployed military systems enabled by linear fiber optic links are described in an appendix.

The occurrence of seismic events in glaciers has been an issue in the scientific literature since the early 1950s, following the report about icequakes in Baffin Island. Targeted seismological studies were undertaken by the Polish Expedition to Spitsbergen in 1962 and then continued at various glaciers in the Arctic, Antarctic and the Alps. The author of the book has been engaged in the project since 1970; he designed the layout of observations and instrumentation. The quakes he observed were categorized into two groups: typical seismic events called icequakes, and relatively long-period events named ice vibrations. In the case of icequakes, the space-time distributions and focal parameters were determined. In the case of ice vibrations, a spectral analysis was made. The present book is a synthesis of the results obtained. There are reports that the number of seismic events in glaciers has recently grown, which may be related to changing geometry of glaciers due to changing thermal conditions.

As the first comprehensive and authoritative review of intra-seasonal variability (ISV), this multi-author work balances coverage of observation, theory and modeling and provides a single source of reference for all those interested in this important, multi-faceted natural phenomenon and its relation to major short-term climatic variations. Commencing with an overview of ISV and observations from an historical perspective, the book offers successive chapters that deal with the role of ISV in monsoon variability on the monsoon regions of South Asia, East Asia and South America, in North America, and in the oceans. The coupling between ocean and atmosphere is considered, together with the function of angular momentum and Earth rotation. Later chapters deal with modeling ISV in the atmosphere and oceans, and the connection between the Madden and Julian Oscillations, and El Nino/Southern Oscillation with short-term climate are considered.