Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies.
Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered.
This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology.
Key Features
* Introduces the relevant aspects of molecular biology and biophysics
* Describes the principal methods used to study channelopathies
* Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function
* Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype

Sodium reabsorbing epithelia play a major role in whole-body sodium homeostasis. Some examples of sodium regulating tissues include kidney, colon, lung, and sweat ducts. Sodium transport across these membranes is a two-step process: entry through an amiloride-sensitive sodium channel and exit via the ouabain-sensitive sodium/potassium ATPase. The sodium entry channels are the rate-limiting determinant for transport and are regulated by several different hormones. The sodium channels also play a significant role in a number of disease states, like hypertension, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity provides the first in-depth exchange of ideas concerning these sodium channels, their regulation and involvement in normal and pathophysiological situations.
Key Features
* Summarizes current state of amiloride-sensitive sodium channel field
* Analyzes structure-function of epithelial sodium channels
* Discusses immunolocalization of epithelial sodium channels
* Examines hormonal regulation of sodium channels
* Discusses sodium channels in lymphocytes, kidney, and lung
* Considers mechanosensitivity of sodium channels
* Provides ideas on sodium channels and disease

The study of the mechanisms that govern origin and propagation of stellar jets involves the treatment of many concurrent physical processes such as gravitation, hydrodynamics and magnetohydrodynamics, atomic physics and radiation. In the past years, an intensive work has been done looking for so- tions of the ideal MHD equations in the steady state limit as well as studying the stability of out?ows in the linear regime. These kind, of approaches have provided a contribution to the understanding of jets that can hardly be ov- estimated. However, the extension of the analyses to the time-dependent and nonlinear regimes could not be avoided, and the MHD numerical simulations were the only mean to achieve this goal. Intherecentyears,considerableprogresseshavebeenmadebythecom- tational?uiddynamiccommunityinthedevelopmentofnumericaltechniques, theso-calledhighresolutionshockcapturingschemes,wellsuitedforthetre- ment of supersonic ?ows with discontinuities. The numerical simulations of astrophysical jets took advantage of these developments; however new physics needed to be incorporated, such as magnetic ?eld e?ects, radiation losses by diluted gases, and proper astrophysics environments. These needs led to the nontrivial extension of the methods devised for the Euler equations of g- dynamics to the magneto-hydrodynamical system. On the other hand, the possibility of carrying out numerical calculations has been greatly facilitated bytheavailability, ononehand,ofpowerfulsupercomputersand,ontheother hand, of fast processors at low cost. Large scale 3D simulations of jets at high resolution are now possible thanks to supercomputers, but also high reso- tion 2D MHD simulations can be performed routinely on desktop computers.

This handbook is a compendium giving a comprehensive description of the basics of semiconductor physics relevant to the design and analysis of thin film solar cell materials. It starts from the basics of material science, describing the material and its growth, defect and electrical properties, the basics of its interaction with photons and the involved statistics, proceeding to space charge effects in semiconductors and pn-junctions. Most attention is given to analyze homo- and hetero-junction solar cells using various models and applying the field-of-direction analysis for discussing current voltage characteristics, and helping to discover the involvement of high-field effects in solar cells. The comprehensive coverage of the main topics of - and relating to - solar cells with extensive reference to literature helps scientists and engineers at all levels to reach a better understanding and improvement of solar cell properties and their production. The author is one of the founders of thin film solar cell research.

In seismology an earthquake source is described in terms of a fault with a particular rupture size. The faulting process of large earthquakes has been investigated in the last two decades through analyses of long-period seismo grams produced by advanced digital seismometry. By long-period far-field approximation, the earthquake source has been represented by physical parameters such as s ismic moment, fault dimension and earthquake mag nitude. Meanwhile, destruction often results from strong ground motion due to large earthquakes at short distances. Since periods of strong ground motion are far shorter than those of seismic waves at teleseismic distances, the theory of long-period source process of earthquakes cannot be applied directly to strong ground motion at short distances. The excitation and propagation of high-frequency seismic waves are of special interest in recent earthquake seismology. In particular, the descrip tion and simulation of strong ground motion are very important not only for problems directly relevant to earthquake engineering, but also to the frac ture mechanics of earthquake faulting. Understanding of earthquake sources has been developed by investigating the complexity of faulting processes for the case of large earthquakes. Laboratory results on rock failures have also advanced the understanding of faulting mechanisms. Various attempts have been made to simulate, theoretically and empirically, the propagation of short-period seismic waves in the heterogeneous real earth."

In this thesis, the author investigates the biophysical basis of the local field potential (LFP) as a way of gaining a better understanding of its underlying physiological mechanisms. The results represent major advances in our understanding and interpretation of LFPs and brain oscillations. They highlight the importance of using suitable experimental and analytical methods to explore the activity of brain circuits and point to the LFP as a useful, but complex variable for this purpose.

Many large-scale projects for detecting gravitational radiation are currently being developed, all with the aim of opening a new window onto the observable Universe. As a result, numerical relativity has recently become a major field of research, and Elements of Numerical Relativity and Relativistic Hydrodynamics is a valuable primer for both graduate students and non-specialist researchers wishing to enter the field.

A revised and significantly enlarged edition of LNP 673 Elements of Numerical Relativity, this book starts with the most basic insights and aspects of numerical relativity before it develops coherent guidelines for the reliable and convenient selection of each of the following key aspects: evolution formalism; gauge, initial, and boundary conditions; and various numerical algorithms. And in addition to many revisions, it includes new, convenient damping terms for numerical implementations, a presentation of the recently-developed harmonic formalism, and an extensive, new chapter on matter space-times, containing a thorough introduction to relativistic hydrodynamics.

While proper reference is given to advanced applications requiring large computational resources, most tests and applications in this book can be performed on a standard PC.

Defined as, "The science about the development of an embryo from the fertilization of the ovum to the fetus stage," embryology has been a mainstay at universities throughout the world for many years. Throughout the last century, embryology became overshadowed by experimental-based genetics and cell biology, transforming the field into developmental biology, which replaced embryology in Biology departments in many universities. Major contributions in this young century in the fields of molecular biology, biochemistry and genomics were integrated with both embryology and developmental biology to provide an understanding of the molecular portrait of a "development cell." That new integrated approach is known as stem-cell biology; it is an understanding of the embryology and development together at the molecular level using engineering, imaging and cell culture principles, and it is at the heart of this seminal book. Stem Cells and Regenerative Medicine: From Molecular Embryology to Tissue Engineering is completely devoted to the basic developmental, cellular and molecular biological aspects of stem cells as well as their clinical applications in tissue engineering and regenerative medicine. It focuses on the basic biology of embryonic and cancer cells plus their key involvement in self-renewal, muscle repair, epigenetic processes, and therapeutic applications. In addition, it covers other key relevant topics such as nuclear reprogramming induced pluripotency and stem cell culture techniques using novel biomaterials. A thorough introduction to stem-cell biology, this reference is aimed at graduate students, post-docs, and professors as well as executives and scientists in biotech and pharmaceutical companies.

As the first comprehensive and authoritative review of intra-seasonal variability (ISV), this multi-author work balances coverage of observation, theory and modeling and provides a single source of reference for all those interested in this important, multi-faceted natural phenomenon and its relation to major short-term climatic variations. Commencing with an overview of ISV and observations from an historical perspective, the book offers successive chapters that deal with the role of ISV in monsoon variability on the monsoon regions of South Asia, East Asia and South America, in North America, and in the oceans. The coupling between ocean and atmosphere is considered, together with the function of angular momentum and Earth rotation. Later chapters deal with modeling ISV in the atmosphere and oceans, and the connection between the Madden and Julian Oscillations, and El Nino/Southern Oscillation with short-term climate are considered.

Compact objects are an important class of astronomical objects in current research. Supermassive black holes play an important role in the understanding of the formation of galaxies in the early Universe. Old white dwarfs are nowadays used to calibrate the age of the Universe. Mergers of neutron stars and black holes are the sources of intense gravitational waves which will be measured in the next ten years by gravitational wave detectors.

Camenzind's Compact Objects in Astrophysics gives a comprehensive introduction and up-to-date overview about the physical processes behind these objects, covering the field from the beginning to most recent results, including all relevant observations.

After a presentation of the taxonomy of compact objects, the basic principles of general relativity are given. The author then discusses in detail the physics and observations of white dwarfs and neutron stars (including the most recent equations of state for neutron star matter), the gravitational field of rapidly rotating compact objects, rotating black holes (including ray tracing and black hole magnetospheres), gravitational waves, and the new understanding of accretion processes by means of the magnetorotational instability of accretion disks.
This modern treatise of compact object astrophysics uses the 3+1 split approach to Einstein's equations, and to relativistic hydrodynamics and magnetohydrodynamics. In each chapter problems and solutions help deepen the understanding of the subject. Both advanced students and researchers will appreciate this book as an advanced textbook and reference on this fascinating field of astrophysics.

Lithium niobate, LiNbO , is an oxide ferroelectric with various kinds of pro- 3 nouncedphysicalproperties. Thisversatilityhaspromoteditscareerinscience anddevices. Ithasbeenparticularlyfruitfulintheopticalregime,wheremany e?ects have been found in LiNbO and devices introduced using it as a host. 3 One of the few big drawbacks, namely the low level laser damage threshold based on photorefraction due to extrinsic defects was discovered very early. A relatively new topic, not involved so far in any general description, is a fundamental dependence of the optical properties of LiNbO on intrinsic de- 3 fects. Their importance has been realised out due to the development of varies growthtechniquesintherecentpast. Theprogressinthegrowthandstudiesof LiNbO crystals with di?erent composition, particularly almost stoichiomet- 3 ric ones, has revealed a signi?cant and sometimes decisive role of the intrinsic defects. For example, the photoinduced charge transport, and therefore the photorefractive properties governing the recording of the phase gratings in LiNbO , are strongly controlled by the content of intrinsic defects. The re- 3 cently found impact of intrinsic defects on the coercive ?eld in LiNbO is 3 of fundamental importance for the creation of periodically poled structures (PPLN) aimed at the optical-frequency conversion in the quasi-phase mat- ing (QPM) mode of operation. As a consequence of these results, an idea of the intrinsic defects in LiNbO has been developed during the last decade 3 and involves microscopic studies on defects, photorefraction and ferroelectric switching using spectroscopic and structure methods.

The second edition of Solar System Astrophysics: Background Science and the Inner Solar System provides new insights into the burgeoning field of planetary astronomy. As in the first edition, this volume begins with a rigorous treatment of coordinate frames, basic positional astronomy, and the celestial mechanics of two and restricted three body system problems. Perturbations are treated in the same way, with clear step-by-step derivations. Then the Earth's gravitational potential field and the Earth-Moon system are discussed, and the exposition turns to radiation properties with a chapter on the Sun. The exposition of the physical properties of the Moon and the terrestrial planets are greatly expanded, with much new information highlighted on the Moon, Mercury, Venus, and Mars. All of the material is presented within a framework of historical importance. This book and its sister volume, Solar System Astrophysics: Background Science and the Inner Solar system, are pedagogically well written, providing clearly illustrated explanations, for example, of such topics as the numerical integration of the Adams-Williamson equation, the equations of state in planetary interiors and atmospheres, Maxwell's equations as applied to planetary ionospheres and magnetospheres, and the physics and chemistry of the Habitable Zone in planetary systems. Together, the volumes form a comprehensive text for any university course that aims to deal with all aspects of solar and extra-solar planetary systems. They will appeal separately to the intellectually curious who would like to know how just how far our knowledge of the solar system has progressed in recent years.

These Proceedings present selected research papers from CSNC2016, held during 18th-20th May in Changsha, China. The theme of CSNC2016 is Smart Sensing, Smart Perception. These papers discuss the technologies and applications of the Global Navigation Satellite System (GNSS), and the latest progress made in the China BeiDou System (BDS) especially. They are divided into 12 topics to match the corresponding sessions in CSNC2016, which broadly covered key topics in GNSS. Readers can learn about the BDS and keep abreast of the latest advances in GNSS techniques and applications.

Research of the interstellar medium (ISM) has been advancing rapidly during the last 10 years, mainly due to immensely improved observational facilities and techniques in all wavelength ranges. We are now able to investigate the ISM in external galaxies and even the intergalactic and intracluster medium in great detail. Increased spatial and spectral resolution have provided us with a great deal of information on the interstellar gas in its various phases, the magnetic field and the cosmic rays, and of course, also the stellar component, which is the driving agent of the interstellar matter cycle.
Since only fairly recently, a sufficient amount of computing power has become available to tackle these problems with some prospect of obtaining a self-consistent picture of the ISM, a major goal of this workshop was to bring together observers and theoreticians sufficiently close, so that intense discussions about the necessities and desiderata of modelling the ISM could be stimulated. Observers have shown in great detail on this conference of what is seen on all scales of the ISM, near and far, and what boundary conditions would be appropriate for realistic models, and theoreticians pointed out what assumptions and simplifications their codes need, and how future observations could test their models. As a first step towards this goal, some self-consistent numerical simulations with a minimum number of relevant physical processes were also presented on this meeting. There was wide agreement, that this approach - to keep observers and theoreticians in close contact and also in sometimes quite controversial discussions - will bear fruitful results in the near future.

With a focus on modified gravity this book presents a review of the recent developments in the fields of gravity and cosmology, presenting the state of the art, high-lighting the open problems, and outlining the directions of future research. General Relativity and the CDM framework are currently the standard lore and constitute the concordance paradigm of cosmology. Nevertheless, long-standing open theoretical issues, as well as possible new observational ones arising from the explosive development of cosmology in the last two decades, offer the motivation and lead a large amount of research to be devoted in constructing various extensions and modifications. In this review all extended theories and scenarios are first examined under the light of theoretical consistency, and are then applied in various geometrical backgrounds, such as the cosmological and the spherical symmetric ones. Their predictions at both the background and perturbation levels, and concerning cosmology at early, intermediate and late times, are then confronted with the huge amount of observational data that astrophysics and cosmology has been able to offer in the last two decades. Theories, scenarios and models that successfully and efficiently pass the above steps are classified as viable and are candidates for the description of Nature, allowing readers to get a clear overview of the state of the art and where the field of modified gravity is likely to go. This work was performed in the framework of the COST European Action "Cosmology and Astrophysics Network for Theoretical Advances and Training Actions" - CANTATA.

This book describes the operation of a particular technique for the production of compound semiconductor materials. It describes how the technique works, how it can be used for the growth of particular materials and structures, and the application of these materials for specific devices. It contains not only a fundamental description of the operation of the technique but also contains lists of data useful for the everyday operation of OMVPE reactors. It also offers specific recipes that can be used to produce a wide range of specific materials, structures, and devices.
Key Features
* Updated with new emphasis on the semiconducting nitride materials-GaN and its alloys with In and Al
* Emphasizes the newly understood aspects of surface processes
* Contains a new chapter, as well as several new sections in chapters on thermodynamics and kinetics

These proceedings contain the reviewed papers presented at the Symposium J on "Ion Implantation into Semiconductors, Oxides and Ceramics," which was held at the Spring Meeting of the European Materials Research Society in Strasbourg, France, 16-19, June 1998. The symposium attracted 110 contributions, with authors from 31 nations in 5 continents. It was thereby the largest in a series of E-MRS ion beam symposia, documenting the importance of ion beam techniques and research in this area.
The aim of this symposium was to provide a forum for the discussion of new results in the implantation of materials from three different classes: semiconductors, oxides and ceramics.

This book mainly focuses on key aspects of biomembranes that have emerged over the past 15 years. It covers static and dynamic descriptions, as well as modeling for membrane organization and shape at the local and global (at the cell level) scale. It also discusses several new developments in non-equilibrium aspects that have not yet been covered elsewhere. Biological membranes are the seat of interactions between cells and the rest of the world, and internally, they are at the core of complex dynamic reorganizations and chemical reactions. Despite the long tradition of membrane research in biophysics, the physics of cell membranes as well as of biomimetic or synthetic membranes is a rapidly developing field. Though successful books have already been published on this topic over the past decades, none include the most recent advances. Additionally, in this domain, the traditional distinction between biological and physical approaches tends to blur. This book gathers the most recent advances in this area, and will benefit biologists and physicists alike.

This book delves into the recent developments in the microscale and microfluidic technologies that allow manipulation at the single and cell aggregate level. Expert authors review the dominant mechanisms that manipulate and sort biological structures, making this a state-of-the-art overview of conventional cell sorting techniques, the principles of microfluidics, and of microfluidic devices. All chapters highlight the benefits and drawbacks of each technique they discuss, which include magnetic, electrical, optical, acoustic, gravity/sedimentation, inertial, deformability, and aqueous two-phase systems as the dominant mechanisms utilized by microfluidic devices to handle biological samples. Each chapter explains the physics of the mechanism at work, and reviews common geometries and devices to help readers decide the type of style of device required for various applications. This book is appropriate for graduate-level biomedical engineering and analytical chemistry students, as well as engineers and scientists working in the biotechnology industry.

Intended for undergraduate non-science majors, satisfying a general education requirement or seeking an elective in natural science, this is a physics text, but with the emphasis on topics and applications in astronomy. The perspective is thus different from most undergraduate astronomy courses: rather than discussing what is known about the heavens, this text develops the principles of physics so as to illuminate what we see in the heavens. The fundamental principles governing the behaviour of matter and energy are thus used to study the solar system, the structure and evolution of stars, and the early universe. The first part of the book develops Newtonian mechanics towards an understanding of celestial mechanics, while chapters on electromagnetism and elementary quantum theory lay the foundation of the modern theory of the structure of matter and the role of radiation in the constitution of stars. Kinetic theory and nuclear physics provide the basis for a discussion of stellar structure and evolution, and an examination of red shifts and other observational data provide a basis for discussions of cosmology and cosmogony.

Acoustics of Layered Media II presents the theory of sound propagation and reflection of spherical waves and bounded beams in layered media. It is mathematically rigorous but at the same time care is taken that the physical usefulness in applications and the logic of the theory are not hidden. Both moving and stationary media, discretely and continuously layered, including a range-dependent environment, are treated for various types of acoustic wave sources. Detailed appendices provide further background on the mathematical methods.This second edition reflects the notable recent progress in the field of acoustic wave propagation in inhomogeneous media.

Generalising Newton's law of gravitation, general relativity is one of the pillars of modern physics. While applications in the beginning were restricted to isolated effects such as a proper understanding of Mercury's orbit, the second half of the twentieth century saw a massive development of applications. These include cosmology, gravitational waves, and even very practical results for satellite based positioning systems as well as different approaches to unite general relativity with another very successful branch of physics - quantum theory. On the occassion of general relativity's centennial, leading scientists in the different branches of gravitational research review the history and recent advances in the main fields of applications of the theory, which was referred to by Lev Landau as "the most beautiful of the existing physical theories". Contributions from: Andy C. Fabian, Anthony L. Lasenby, Astrophysical black Holes Neil Ashby, GNSS and other applications of General Relativity Gene Byrd, Arthur Chernin, Pekka Teerikorpi, Mauri Vaaltonen, Observations of general Relativity at strong and weaks limits Ignazio Ciufolini, General Relativity and dragging of inertial frames Carlo Rovelli, The strange world of quantum spacetime

Neutron stars are the most compact astronomical objects in the universe which are accessible by direct observation. Studying neutron stars means studying physics in regimes unattainable in any terrestrial laboratory.

Understanding their observed complex phenomena requires a wide range of scientific disciplines, including the nuclear and condensed matter physics of very dense matter in neutron star interiors, plasma physics and quantum electrodynamics of magnetospheres, and the relativistic magneto-hydrodynamics of electron-positron pulsar winds interacting with some ambient medium. Not to mention the test bed neutron stars provide for general relativity theories, and their importance as potential sources of gravitational waves. It is this variety of disciplines which, among others, makes neutron star research so fascinating, not only for those who have been working in the field for many years but also for students and young scientists.

The aim of this book is to serve as a reference work which not only reviews the progress made since the early days of pulsar astronomy, but especially focuses on questions such as: "What have we learned about the subject and how did we learn it?," "What are the most important open questions in this area?" and "What new tools, telescopes, observations, and calculations are needed to answer these questions?."

All authors who have contributed to this book have devoted a significant part of their scientific careers to exploring the nature of neutron stars and understanding pulsars. Everyone has paid special attention to writing educational comprehensive review articles with the needs of beginners, students and young scientists as potential readers in mind. This book will be a valuable source of information for these groups.

This volume contains the proceedings of The Second Polish-US Conf- ence on High Temperature Superconductivity which was held August 18-21, 1998 in Karpacz, Poland. The conference followed The First Polish-US C- ference on High Temperature Superconductivity organized in 1995, proce- ings of which were published by Springer-Verlag in 1996 (Recent Devel- ments in High Temperature Superconductivity, Lecture Notes in Physics 475). High Temperature Superconductivity (HTSC) in complex copper oxides has become a household name after twelve years of intense research following its discovery in 1986 by J. G. Bednorz and K. A. Miiller. Because of the rapid growth of the HTSC field, there is a need for periodic summary and conden- tion both for scientists working in the field and, especially, for young resear- ers entering the field of oxide materials. Following the First Conference, it was recognized that an extended format of lectures perfectly satisfied that need, providing adequate time for experts from the international community to fully introduce and develop complex ideas. Thus, the format of the Second Conference brought together by cooperating scientists from the Institute of Low Temperature and Structure Research of the Polish Academy of Science at Wroctaw, Northern Illinois University, and Argonne National Laboratory remained mostly unchanged. Again, we were delighted to receive enthusiastic responses from distinguished US and Polish scientists who were invited to p- ticipate.

Dealing with astrophysics derived from the radiation emitted by radioactive atomic nuclei, this book describes the different methods used to measure cosmic radio-isotopes. It demonstrates how this astronomical window has contributed to the understanding of the sources and the chemical evolution of cosmic gas. Reference materials and explanations are included for students in advanced stages of their education. Nuclear reactions in different sites across the universe lead to the production of stable and unstable nuclei. Their abundances can be measured through different methods, allowing to study the various nuclear processes taking place in cosmic environments. Nucleosynthesis is the cosmic formation of new nuclear species, starting from hydrogen and helium resulting from the big bang origins. Stars create and eject synthesized nuclei during their evolution and explosions. Incorporation of the new interstellar composition into next-generation stars characterises the compositional (chemical) evolution of cosmic gas in and between galaxies. Radioactive species have unique messages about how this occurs. Since the first Edition of this book published in 2011 with the title Astronomy with Radioactivities, long-awaited new direct observations of supernova radioactivity have been made and are now addressed in two updated chapters dealing with supernovae. In this second Edition, the advances of recent years beyond one-dimensional treatments of stellar structure and stellar explosions towards 3-dimensional models have been included, and led to significant re-writings in Chapters 3-5. The sections on the Solar System origins have been re-written to account for new insights into the evolution of giant molecular clouds. The chapter on diffuse radioactivities now also includes material measurements of radioactivities in the current solar system, and their interpretations for recent nucleosynthesis activity in our Galaxy. Significant new results on gamma-rays from positron annihilations have been accounted for in that chapter, and led to new links with nucleosynthesis sources as well as interstellar transport processes. A new chapter now provides a description of interstellar processes often called 'chemical evolution', thus linking the creation of new nuclei to their abundance observations in gas and stars. The experimental / instrumental chapters on nuclear reaction measurements, on gamma-ray telescopes, and pre-solar grain laboratories have been updated. Moreover, new windows of astronomy that have been opened up in recent years have been included in the discussions of the multi-messenger approach that broadens the basis for astrophysical insights.