This second edition of the book on Store-operated Ca2+ Entry Pathways has been updated with the newest discoveries that emerged in the field within the last five years. The crystal structure of the Ca2+ signaling core complex is described which adds to a new understanding of the molecular interactions involved. Each chapter has been revised and extended. The book retains its interdisciplinary approach and supplies biochemists, cell biologists and biophysicists as well as clinicians in immunology, neurology and cardiology with valuable information on Ca2+ signaling mechanisms, functions, dysfunctions and their consequences.

Stephen Hawking, the Lucasian Professor of Mathematics at Cambridge University, has made important theoretical contributions to gravitational theory and has played a major role in the development of cosmology and black hole physics.

Hawking's early work, partly in collaboration with Roger Penrose, showed the significance of spacetime singularities for the big bang and black holes. His later work has been concerned with a deeper understanding of these two issues. The work required extensive use of the two great intellectual achievements of the first half of the Twentieth Century: general relativity and quantum mechanics; and these are reflected in the reprinted articles. Hawking's key contributions on black hole radiation and the no-boundary condition on the origin of the universe are included.

The present compilation of Stephen Hawking's most important work also includes an introduction by him, which guides the reader though the major highlights of the volume. This volume is thus an essential item in any library and will be an important reference source for those interested in theoretical physics and applied mathematics.

It is an excellent thing to have so many of Professor Hawking's most important contributions to the theory of black holes and space-time singularities all collected together in one handy volume. I am very glad to have them". Roger Penrose (Oxford)

"This was an excellent idea to put the best papers by Stephen Hawking together. Even his papers written many years ago remain extremely useful for those who study classical and quantum gravity. By watching the evolution of his ideas one can get a very clear picture of the development of quantum cosmology during thelast quarter of this century". Andrei Linde (Stanford)

"This review could have been quite short: 'The book contains a selection of 21 of Stephen Hawking's most significant papers with an overview written by the author'. This would be sufficient to convince any researcher, student or librarian to acquire the book, so indisputable is the contribution of this man to the theoretical physics of the last half of our century ... Collected together, these brilliant works constitute a valuable contribution to the literature on modern classical and quantum gravity and cosmology. This book will certainly be a source of inspiration for new generations of physicists entering into this fascinating area of research". D Gal'tsov Classical & Quantum Gravity

The work developed in this thesis addresses very important and relevant issues of accretion processes around black holes. Beginning by studying the time variation of the evolution of inviscid accretion discs around black holes and their properties, the author investigates the change of the pattern of the flows when the strength of the shear viscosity is varied and cooling is introduced. He succeeds to verify theoretical predictions of the so called Two Component Advective Flow (TCAF) solution of the accretion problem onto black holes through numerical simulations under different input parameters. TCAF solutions are found to be stable. And thus explanations of spectral and timing properties (including Quasi-Period Oscillations, QPOs) of galactic and extra-galactic black holes based on shocked TCAF models appear to have a firm foundation.

This thesis reports on the development of the first quantum enhanced microscope and on its applications in biological microscopy. The first quantum particle-tracking microscope, described in detail here, represents a pioneering advance in quantum microscopy, which is shown to be a powerful and relevant technique for future applications in science and medicine. The microscope is used to perform the first quantum-enhanced biological measurements -- a central and long-standing goal in the field of quantum measurement. Sub diffraction-limited quantum imaging is achieved, also for the first time, with a scanning probe imaging configuration allowing 10-nanometer resolution.

Gamma-ray astronomy began in the mid-1960s with balloon satellite, and, at very high photon energies, also with ground-based instruments. However, the most significant progress was made in the last decade of the 20th century, when the tree satellite missions SIGMA, Compton, and Beppo-Sax gave a completely new picture of our Universe and made gamma-ray astronomy an integral part of astronomical research. This book, written by well-known experts, gives the first comprehensive presentation of this field of research, addressing both graduate students and researchers. Gamma-ray astronomy helps us to understand the most energetic processes and the most violent events in the Universe. After describing cosmic gamma-ray production and absorption, the instrumentation used in gamma-ray astronomy is explained. The main part of the book deals with astronomical results, including the somewhat surprising result that the gamma-ray sky is continuously changing.

Natural saline water, waste water, and irrigation return flow endanger the groundwater aquifers in the Rift. In the long run this will ruin the socio-economic backbone of the settlements in the area. Sustainability of the water resources will only be achieved when the process of water replenishment and its underground flow is understood and water extraction is regionally controlled. Rare earth element and spider patterns are presented as new tools for studying the hydrology. Progress in 3-D modelling of groundwater flow proved successfully the impact of pumping on the surroundings of wells and overexploitation of aquifers.

As a research subject, the biomechanics of the urinary bladder are relatively young, yet medical problems associated with them are as old as mankind. Offering an update on recent achievements in the field, the authors highlight the underlying biological, chemical and physical processes of bladder function and present the systematic development of a mathematical model of the organ as a thin, soft biological shell. The book will be a valuable resource for postgraduate students and researchers interested in the applications of computational mathematics and solid mechanics to modern problems in biomedical engineering and medicine.

This text discusses mathematical modelling, analysis and control of the immune system and disease dynamics. The purpose of the book is the practical application of mathematics to immunology and medicine in order to establish a basis for more effective treatment, to provide a tutorial systematic description of how the immune system controls diseases and to present several significant examples such as malignant tumour dynamics and control, and viral hepatitis. The book is multidisciplinary in content, with the intended readers including biomathematicians, biologists and physicists. It combines immunological principles, mathematical models, computer simulations and methods of analysis.

This doctoral thesis applies measurements of ground deformation from satellite radar using their potential to play a key role in understanding volcanic and magmatic processes throughout the eruption cycle. However, making these measurements is often problematic, and the processes driving ground deformation are commonly poorly understood. These problems are approached in this thesis in the context of the Cascades Volcanic Arc. From a technical perspective, the thesis develops a new way of using regional-scale weather models to assess a priori the influence of atmospheric uncertainties on satellite measurements of volcano deformation, providing key parameters for volcano monitoring. Next, it presents detailed geodetic studies of two volcanoes in northern California: Medicine Lake Volcano and Lassen Volcanic Centre. Finally, the thesis combines geodetic constraints with petrological inputs to develop a thermal model of cooling magma intrusions. The novelty and range of topics covered in this thesis mean that it is a seminal work in volcanic and magmatic studies.

The study of dielectric properties of biological systems and their components is important not only for fundamental scientific knowledge but also for its applications in medicine, biology, and biotechnology. The associated technique - known as dielectric spectroscopy - has enabled researchers to quickly and accurately acquire time- or frequency-spectra of permittivity and conductivity and permitted the derivation and testing of realistic electrical models for cells and organelles. This text covers the theoretical basis and practical aspects of the study of dielectric properties of biological systems, such as water, electrolyte and polyelectrolytes, solutions of biological macromolecules, cells suspensions and cellular systems. The authors' combined efforts provide a comprehensive and cohesive book that takes advantage of the expertise of multiple scientists involved in cutting-edge research in the specific sub-fields of bio-dielectric spectroscopy while maintaining its self-consistency through numerous discussions. The first six chapters cover theoretical, methodological and experimental aspects of relaxation and dispersion in biological dielectrics at molecular, cellular and cellular aggregate level. Applications are presented in the following chapters which are organized in the order of increased complexity, beginning with pure water, amino acids and proteins, continuing with vesicles and simple cells such as erythrocytes, and then with more complex, organelle-containing cells and cellular aggregates. Due to its broad coverage, the text could be used as a reference book by researchers, and as a textbook for upper-level undergraduate classes and graduate classes in (bio) physics, medical physics, quantitative biology, and engineering.

Many biological phenomena are especially interesting from a physical point of view, and recent developments have made it possible to perform quantitative, 'physics-style' experiments on many different biological systems. In this volume, composed largely of lectures at a summer workshop for students in 1991, many of those emerging problems in biophysics are surveyed, with emphasis on the confrontation between theory and experiment. The topics range from the structure and dynamics of individual biological molecules to the computational strategies of the nervous system.

On September 15, 2017, the Cassini spacecraft sent its final transmission to the Earth as it entered the atmosphere of Saturn, ending its historic 13 year mission at the ringed planet. This book is a beautifully illustrated journey of discovery through the Saturn system. Cassini's instruments have revealed never seen before details, including the only extraterrestrial lakes known in the solar system, and have provided unprecedented views of the rings, moons, and the planet itself. Results from Cassini's dramatic Grand Finale of ring-grazing and planet-skimming orbits are included in this expanded and updated second edition. Saturn is the jewel of the solar system. The Cassini spacecraft has been exploring the ringed planet and its moons and rings since 2004 and has helped us solve many of its mysteries while generating a wealth of new questions. Cassini has observed the bizarre mountains of Iapetus, the geysers of Enceladus, the lakes of Titan, and the dynamic and evolving rings. Along the way, this book explores and explains the fundamental processes that shape not just the Saturn system, but planets and moons in general. Written for the general audience with an emphasis on the fundamental physics of planetary systems, The Ringed Planet is a fascinating exploration of the Saturn system that places Saturn in the context of the solar system as a whole. Cassini's instruments have revealed Enceladus and Titan to have subsurface oceans of liquid water. Its cameras have returned stunning images of rings in turmoil, a tumbling moon, the only extraterrestrial lakes known in the solar system, a hexagon of clouds, some of the highest mountains in the solar system and much more. More than a journey of discovery at Saturn, The Ringed Planet is also an introduction to how planetary systems work.

In this book, the fundamental knowledge involved in petroleum & gas development engineering, such as physical and chemical phenomena, physical processes and the relationship between physical factors is covered. It is arranged into 3 Sections. Section 1 including chapter 1-4 is to introduce the properties of fluids (gases, hydrocarbon liquids, and aqueous solutions). Section II including Chapter 5-7 is to introduce the porous rock properties of reservoir rocks. Section III including Chapter 8-10 is to introduce the mechanism of multiphase fluid flow in porous medium. The book is written primarily to serve professionals working in the petroleum engineering field. It can also be used as reference book for postgraduate and undergraduate students as well for the related oil fields in petroleum geology, oil production engineering, reservoir engineering and enhancing oil recovery.

This unique volume contains the proceedings of two "Non-Sleeping Universe" conferences: "Stars and the ISM" and "From Galaxies to the Horizon." The book provides an overview of recent developments in a variety of areas, covering a very wide range of spatial and temporal scales.

This volume contains the Proceedings of the Fourth Scientific Meeting of the Spanish Astronomical Society (Sociedad Espanola de Astronomfa, SEA). The meeting was held at the Universidade de Santiago de Compostela in Galicia from September 11 to 14, 2000. The event brought together 156 participants who pre- sented their latest results in many different subjects. In comparison with the previous scientific meetings of the Society, the numbers of oral talks and poster contributions (95 and 51, respectively) are rapidly increasing, confirming that the SEA conferences are becoming a point of reference to assess the interests and achievements of astrophysical research in Spain. During the meeting, the SEA made public the granting of the Prize to the Best Spanish Ph. D. Thesis in As- tronomy and Astrophysics for the period 1998-1999 to Dr. H. Socas. This is the first time that the SEA is awarding this prize, which aim is to encourage young spanish astrophysicists to pursue a high level scientific career. The Society is indebted to the Universidade de Santiago de Compostela, and, in particular, to the Observatorio Astronomico Ramon Marfa Aller, for its hospi- tality. The Local Organizing Committee took care of all the logistics details to ensure a nice stay for all the participants. The effort of the Scientific Organizing Committee was decisive in determining the organizational and scientific success of the meeting.

Rationality - as opposed to 'ad-hoc' - and asymptotics - to emphasize the fact that perturbative methods are at the core of the theory - are the two main concepts associated with the Rational Asymptotic Modeling (RAM) approach in fluid dynamics when the goal is to specifically provide useful models accessible to numerical simulation via high-speed computing. This approach has contributed to a fresh understanding of Newtonian fluid flow problems and has opened up new avenues for tackling real fluid flow phenomena, which are known to lead to very difficult mathematical and numerical problems irrespective of turbulence. With the present scientific autobiography the author guides the reader through his somewhat non-traditional career; first discovering fluid mechanics, and then devoting more than fifty years to intense work in the field. Using both personal and general historical contexts, this account will be of benefit to anyone interested in the early and contemporary developments of an important branch of theoretical and computational fluid mechanics.

This interdisciplinary meeting has brought together a group of astrophysicists with hands-on experience in the numerical computation of astrophysical fluid dynamics, in particular nonlinear stellar pulsations, and a group of applied mathematicians who are actively engaged with the development of novel and improved numerical methods. The goal of the workshop has been for the astrophysicists to discuss in detail the numerical problems encountered in the modelling of stellar pulsations and for the mathematicians to present a survey of recent developments in numerical techniques. This astrophysical-mathematical intercourse will help the astrophysicists in the future development of more reliable and efficient codes, on the one hand, and it has introduced the mathematicians to an unfamiliar area which is a tough testing ground for their techniques. Since the difficulties encountered are common to other fluid dynamics problems, and are in fact perhaps more severe, fluid dynamicists in other research areas may fmd the results of this workshop of interest as well. Much of our theoretical understanding of the intricate and interesting behavior of variable stars rests on our ability to perform accurate numerical hydrodynamical computations of stellar models. Extensive calculations of nonlinear radial stellar pulsations with the use of increasingly powerful computers are showing more and more clearly that the numerical codes in current use have serious deficiencies.

This book will bring together experts in the field of astronomical photometry to discuss how their subfields provide the precision and accuracy in astronomical energy flux measurements that are needed to permit tests of astrophysical theories. Differential photometers and photometry, improvements in infrared precision, theimprovements in precision and accuracy of CCD photometry, the absolute calibration of flux, the development of the Johnson UBVRI photometric system and other passband systems to measure and precisely classify specific types of stars and astrophysical quantities, and the current capabilities of spectrophotometry, and polarimetry to provide precise and accurate data, will all be discussed in this volume. The discussion of differential or two-star photometers will include those developed for planetary as well as stellar photometry and will range from the Princeton polarizing photometer through the pioneering work of Walraven to the differential photometers designed to measure the ashen light of Venus and to counter the effects of aurorae at high latitude sites; the last to be discussed will be the Rapid Alternate Detection System (RADS) developed at the University of Calgary in the 1980s."

Cognition and artificial intelligence are entering a new era in which the aspects of symbolic manipulation and of connectionism begin to come together. This leads to a dialog of truly interdisciplinary character. The book covers aspects of fuzzy logic, case based reasoning, learning as well as meaning, language, and consciousness. The authors of this topical volume have their background in logic, computer science, physics and mathematics, philosophy, psychology and neurobiology.

This book focuses on all of the major problems associated with the absence of body weight in space, by analyzing effects, adaption, and re-adaptation upon returning to Earth, using sound scientific principles embedded in a historical context. Serious problems for space travelers range from Space Motion Sickness (SMS) to recently discovered ocular effects that may permanently impair vision. Fluid loss and shifts, spinal changes, and bone and muscle loss are also all results of weightlessness. Starting with a brief definition and history of weightlessness, the authors then address in detail each problem as well as the countermeasures aimed at alleviating them. In some cases, alternative hypotheses regarding what can and should be attempted are also presented. As plans for long-term missions to the Moon and Mars develop, it will be essential to find countermeasures to weightlessness that are effective for missions that could span years.

Les deuxiernes "Rencontres de l'Observatoire", qui ont eu lieu a l'Observatoire de Paris a Meudon du 10 au 14 Janvier 2000, ont reuni autour du theme "Problernes ernergents en physique de I'espace" 120 physiciens et astrophysiciens venus d'une vingtaine de pays differents. Nous avons voulu honorer a cette occasion Jean-Louis Steinberg pour ses con- tributions majeures a la recherche spatiale, ala radioastronomie et a la physique de I'espace. L'approche explicitement pluridisciplinaire de ce colloque, qui ne s'est pas laisse confiner dans les limites etroites de la physique spatiale ni dans celles imposees par certains programmes officiels, suit l'esprit de sa carriere scientifique: sortir des limites des sujets deja etudies ou sur Ie point de l'etre, et appliquer les connaissances acquises pour explorer de nouveaux domaines. Ce dernier quart de siecle a vu une croissance vertigineuse des performances spatiales. La technologie moderne ne perrnet pas encore de jongler avec les univers comme Ie prestidigitateur de Grandville (Grandville, Un autre monde, ed. H. Four- nier, Paris, 1844); mais quelques decades ont suffi pour voir des instruments soph- istiques explorer les frontieres du systerne solaire, et la cornmunaute de la recher- che spatiale a depasse rapidement Ie sujet etroit de I'environnement soleil-terre pour s'interesser a I'ensemble de l'heliosphere, OU les memes processus physiques sont a I'ceuvre.

The nature of dark matter remains one of the preeminent mysteries in physics and cosmology. It appears to require the existence of new particles whose interactions to ordinary matter are extraordinarily feeble. One well-motivated candidate is the axion, an extraordinarily light neutral particle that may possibly be detected by looking for their conversion to detectable microwaves in the presence of a strong magnetic field. This has led to a number of experimental searches that are beginning to probe plausible axion model space and may discover the axion in the near future. These proceedings discuss the challenges of designing and operating tunable resonant cavities and detectors at ultralow temperatures. The topics discussed here have potential application far beyond the field of dark matter detection and may be applied to resonant cavities for accelerators as well as designing superconducting detectors for quantum information and computing applications. This work is intended for graduate students and researchers interested in learning the unique requirements for designing and operating microwave cavities and detectors for direct axion searches and to introduce several proposed experimental concepts that are still in the prototype stage.

The information received from BeppoSAX, Chandra and other instruments in the last two years has more than doubled the number of samples of Gamma-Ray Bursts localized and followed up for afterglow search. This has also increased the interest of astronomers in GRBs. This book reviews the research of the last two years and covers the global properties of GRBs, GRB afterglows, GRB host galaxies, cosmology using GRBs, and theories for GRBs and their afterglows. Theoretical and observational aspects are presented as well as tools for the analysis of the data.

The feasibility to extract porous medium parameters from acoustic recordings is investigated. The thesis gives an excellent discussion of our basic understanding of different wave modes, using a full-waveform and multi-component approach. Focus lies on the dependency on porosity and permeability where especially the latter is difficult to estimate. In this thesis, this sensitivity is shown for interface-wave and reflected-wave modes. For each of the pseudo-Rayleigh and pseudo-Stoneley interface waves unique estimates for permeability and porosity can be obtained when impedance and attenuation are combined.
The pseudo-Stoneley wave is most sensitive to permeability: both the impedance and the attenuation are controlled by the fluid flow. Also from reflected-wave modes unique estimates for permeability and porosity can be obtained when the reflection coefficients of different reflected modes are combined. In this case the sensitivity to permeability is caused by subsurface heterogeneities generating mesoscopic fluid flow at seismic frequencies. The results of this thesis suggest that estimation of in-situ permeability is feasible, provided detection is carried out with multi-component measurements. The results of this thesis argely affect geotechnical and reservoir engineering practices.

This volume is composed of extensive and detailed notes from the lectures given at the 40th Karpacz Winter School. This school focussed on quantum gravity phenomenology with emphasis on its relation to observational astrophysics and cosmology. These notes have been carefully edited with the aim to give advanced students and young researchers a balanced and accessible introduction to a rather heavily mathematical subject.