This book provides a molecular view of membrane transport by means of numerous biochemical and biophysical techniques. The rapidly growing numbers of atomic structures of transporters in different conformations and the constant progress in bioinformatics have recently added deeper insights.The unifying mechanism of energized solute transport across membranes is assumed to consist of the conformational cycling of a carrier protein to provide access to substrate binding sites from either side of a cellular membrane. Due to the central role of active membrane transport there is considerable interest in deciphering the principles of one of the most fundamental processes in nature: the alternating access mechanism.This book brings together particularly significant structure-function studies on a variety of carrier systems from different transporter families: Glutamate symporters, LeuT-like fold transporters, MFS transporters and SMR (RND) exporters, as well as ABC-type importers.The selected examples impressively demonstrate how the combination of functional analysis, crystallography, investigation of dynamics and computational studies has made it possible to create a conclusive picture or more precisely, a molecular movie . Although we are still far from a complete molecular description of the alternating access mechanism, remarkable progress has been made from static snapshots towards membrane transport dynamics."

This monograph, unique in the literature, is the first to develop a mathematical theory of gravitational lensing. The theory applies to any finite number of deflector planes and highlights the distinctions between single and multiple plane lensing. Introductory material in Parts I and II present historical highlights and the astrophysical aspects of the subject. Among the lensing topics discussed are multiple quasars, giant luminous arcs, Einstein rings, the detection of dark matter and planets with lensing, time delays and the age of the universe (Hubble's constant), microlensing of stars and quasars. The main part of the book---Part III---employs the ideas and results of singularity theory to put gravitational lensing on a rigorous mathematical foundation and solve certain key lensing problems. Results are published here for the first time. Mathematical topics discussed: Morse theory, Whitney singularity theory, Thom catastrophe theory, Mather stability theory, Arnold singularity theory, and the Euler characteristic via projectivized rotation numbers. These tools are applied to the study of stable lens systems, local and global geometry of caustics, caustic metamorphoses, multiple lensed images, lensed image magnification, magnification cross sections, and lensing by singular and nonsingular deflectors. Examples, illustrations, bibliography and index make this a suitable text for an undergraduate/graduate course, seminar, or independent thesis project on gravitational lensing. The book is also an excellent reference text for professional mathematicians, mathematical physicists, astrophysicists, and physicists.

Current understanding of different phases as well as the phase transitions between them has only been achieved following recent theoretical advances on the effects of dimensionality in statistical physics. P S Pershan explains the connection between these two separate areas and gives some examples of problems where the understanding is still not complete. The most important example is the second order phase transition between the nematic and smectic-A phase. Others include the relation between the several hexatic phases that have been observed and the first order restacking transitions between phases that were all previously identified as smectic-B, but which should more properly be identified as crystalline-B. Some relatively recent experimental developments on the discotic phase, liquid crystal surfaces and lyotropic phases are also included. The book includes 41 major reprints of some of the recent seminal work on the structure of liquid crystals. They are introduced by a brief review of the symmetries and other properties of liquid crystalline phases. In addition, there is a discussion of the differences between true liquid crystalline phases and others that were described as liquid crystalline in the early literature, but which have since been shown to be true three-dimensional crystals. The progression from the isotropic fluid, through the nematic, smectic, and various crystalline phases can be understood in terms of a systematic decrease in symmetry, together with an accompanying variation in structure is explained. A guide to the selected reprints and a sort of "Rosetta Stone" for these various phases is provided. The goal of this book is to explain the systematics of this progression to students and others that are new to this field, as well as to provide a useful handbook for people already working in the field.

With a length of about 1200 km, the Son-Narmada-Tapti Lineament (NSL) is one of the most prominent geomorphic features in the Indian subcontinent. Anomalous conductive bodies are delineated at mid-lower crustal depths below major earthquake epicentral zones. The region has been interpreted as the collision zone of the Indian Plate with the Eurasian Plate. The NSL zone is therefore also known to be the second most important tectonic feature in the Indian geology, after the Himalayas.
The present thesis describes significant new insight into the seismotectonics of this Central India tectonic zone, based on thorough magnetotelluric studies. The main objectives of the present study are: (i) to delineate subtrappean sediments across the NSL region along four different traverses, (ii) to understand the characterization of geo-electrical structure of the crust and examine the nature of geo-electrical signatures of the known faults, (iii) to integrate the results with other geophysical data such as seismicity, gravity and heat flow, in order to understand the tectonic scenario of the region.
Deep electromagnetic (magnetotelluric) analyses were integrated in this study with gravity, seismic and heat flow studies and distinct, delineated deep crustal features. The resulting high conductivity is justified with the presence of fluids at mid-lower crustal depths. The migration of these fluids from mantle to mid-lower crustal depths through pre-existing brittle fracture/fault zones were obviously caused by the plume related to the Deccan volcanism. Migration of the fluids generated a higher fluid pressure along the faults and resulted in earthquakes.
Based on the geo-electric sections derived along the four traverses of the Narmada-Son Lineament Zone, the present study gives important clues on the subduction/collision history in this important tectonic zone.

This book is an edited version of lectures given by the authors at the 1985 Jilin University Summer School on Laser Physics. The School was held at Jilin University in Changchun, Peoples' Republic of China.

This book provides an exhaustive account of the origin and dynamics of cosmic rays. Divided into three parts, it first gives an up-to-date summary of the observational data, then -- in the following theory section -- deals with the kinetic description of cosmic ray plasma. The underlying diffusion-convection transport equation, which governs the coupling between cosmic rays and the background plasma, is derived and analyzed in detail. In the third part, several applications of the solutions of the transport equation are presented and how key observations in cosmic ray physics can be accounted for is demonstrated. The applications include cosmic ray modulation, acceleration near shock waves and the galactic propagation of cosmic rays. While the book is primarily of interest to scientists working at the forefront of research, the very careful derivations and explanations make it suitable also as an introduction to the field of cosmic rays for graduate students.

Magnetized plasmas in the universe exhibit complex dynamical behavior over a huge range of scales. The fundamental mechanisms of energy transport, redistribution and conversion occur at multiple scales. The driving mechanisms often include energy accumulation, free-energy-excited relaxation processes, dissipation and self-organization. The plasma processes associated with energy conversion, transport and self-organization, such as magnetic reconnection, instabilities, linear and nonlinear waves, wave-particle interactions, dynamo processes, turbulence, heating, diffusion and convection represent fundamental physical effects. They demonstrate similar dynamical behavior in near-Earth space, on the Sun, in the heliosphere and in astrophysical environments. 'Multi-scale Dynamical Processes in Space and Astrophysical Plasmas' presents the proceedings of the International Astrophysics Forum Alpbach 2011. The contributions discuss the latest advances in the exploration of dynamical behavior in space plasmas environments, including comprehensive approaches to theoretical, experimental and numerical aspects. The book will appeal to researchers and students in the fields of physics, space and astrophysics, solar physics, geophysics and planetary science.

Starting from Sophus Lie, the invariance of a differential equation under its continuous group of symmetries has become a major tool for solving ordinary and partial differential equations, in particular, nonlinear ones. The proceedings focus on the application of these techniques to nonlinear partial differential equations. The state of the art in this field is presented clearly in a series of comprehensive lectures. Several lectures on applications point out the physical importance of such methods.

Mechanics plays a central role in determining form and function in biology. This holds at the cellular, molecular and tissue scales. At the cellular scale, mechanics in?uences cell adhesion, cytoskeletal dynamics and the traction that the cell can generate on a given substrate. All of these in turn - fect the cellular functions of migration, mitosis, phagocytosis, endocytosis and stem cell differentiation among others. Indeed, if cells do not develop the appropriate stresses, they are unviable and die. These aspects of cell mechanics are frequently used by mainstream biologists, as traditional mechanicians may be surprised to learn. There is a growing view that many functions of the cell are mechanical in nature even though chemical signals play crucial roles in the processes. Free energy barriers control transitions between different conformations of vir- ally every macromolecule including DNA, RNA, the adhesion protein integrin, the motor protein myosin, and the proteins vinculin and talin that link the cytoskeleton to focal adhesions. The strain energy can be a signi?cant component of the total free energy barrier. For binding to take place, the macromolecules need to be in conf- mational states that expose chemical groups without steric hinderance. The kinetics of chemical reactions are therefore strongly in?uenced by the conformational strain energy.

This book addresses the subject of gravity theories in two and three spacetime dimensions. The prevailing philosophy is that lower dimensional models of gravity provide a useful arena for developing new ideas and insights, which are applicable to four dimensional gravity. The first chapter consists of a comprehensive introduction to both two and three dimensional gravity, including a discussion of their basic structures. In the second chapter, the asymptotic structure of three dimensional Einstein gravity with a negative cosmological constant is analyzed. The third chapter contains a treatment of the effects of matter sources in classical two dimensional gravity. The fourth chapter gives a complete analysis of particle pair creation by electric and gravitational fields in two dimensions, and the resulting effect on the cosmological constant. Lower dimensional gravity may have never been reviewed in its entirety anywhere in the literature.

Anyone who has experienced turbulence in flight knows that it is usually not pleasant, and may wonder why this is so difficult to avoid. The book includes papers by various aviation turbulence researchers and provides background into the nature and causes of atmospheric turbulence that affect aircraft motion, and contains surveys of the latest techniques for remote and in situ sensing and forecasting of the turbulence phenomenon. It provides updates on the state-of-the-art research since earlier studies in the 1960s on clear-air turbulence, explains recent new understanding into turbulence generation by thunderstorms, and summarizes future challenges in turbulence prediction and avoidance.

The present 15th volume of the ISSI Space Science Series is devoted to Auroral Plasma Physics. The aurora is arguably the most intriguing phenomenon in space plasma physics. Not only is it the most spectacular manifestation of the Sun-Earth connection chain, but the underlying plasma processes are expected to be ubiqui- tous in the plasma universe. Recognizing the enormous progress made over the last decade in the understanding of the physics of the auroral acceleration processes, it seemed timely to write a comprehensive and integrated book on the subject. Re- cent advances concern the clarification of the nature of the acceleration process of the electrons that are responsible for the visible aurora, the recognition of the fundamental role of the large-scale current systems in organizing the auroral mor- phology, and of the interplay between particles and electromagnetic fields. The project began in March 1999, as a natural follow-up of the project on Magnetospheric Plasma Sources and Losses that resulted in volume 6 of this se- ries, with a planning meeting by a core-group that coordinated the project. The group consisted of J. E. Borovsky, Los Alamos National Laboratory; C. W. Carl- son, University of California, Berkeley; G. Haerendel, Max-Planck-Institut fur ex- traterrestrische Physik, Garching; B. Hultqvist, Swedish Intitute ofSpace Physics, H. E. J. Koskinen, Finnish Meteorological Institute, Helsinki; W. Lotko, Kiruna; Dartmouth College, Hanover, New Hampshire; K. A. Lynch, University of New Hampshire, Durham and G. Marklund, Royal Institute ofTechnology, Stockholm. G. Paschmann, ISSI, Bern, was the project leader.

The need for tsunami research and analysis has grown dramatically following the devastating tsunami of December 2004, which affected Southern Asia. This book pursues a detailed theoretical and mathematical analysis of the fundamentals of tsunamis, especially the evolution and dynamics of tsunamis and other great waves. Of course, it includes specific measurement results from the 2004 tsunami, but the emphasis is on the nature of the waves themselves and their links to nonlinear phenomena.

This volume describes the state-of-knowledge in the study of the relationships between mechanical loading states in tissues and common pathophysiologies related to increase in mass of adipose tissues and/or hyperglycemia which eventually lead to obesity, diabetes, insulin resistance, hyperlipidemia, metabolic inflammations, certain types of cancer and other related diseases. There appears to be an interaction between the loading states in tissues and cells and these chronic conditions, as well as with factors such as age, gender and genetics of the individual. Bioengineering has made key contributions to this research field in providing technologies for cell biomechanics experimentation, microscopy and image processing, tissue engineering and multi-scale, multi-physics computational modeling. Topics at the frontier of this field of study include: the continuous monitoring of cell growth, proliferation and differentiation in response to mechanical factors such as stiffness of the extracellular matrix (ECM) and mechanical loads transferred through the ECM; mechanically-activated signaling pathways and molecular mechanisms; effects of different loading regimes and mechanical environments on differentiation fates of mesenchymal stem cells (MSCs) into myogenic and osteogenic versus adipogenic lineages; the interactions between nutrition and mechanotransduction; cell morphology, focal adhesion patterns and cytoskeletal remodeling changes in adipogenesis; activation of receptors related to diabetes by mechanical forces; brown and white adipose plasticity and its regulation by mechanical factors.

If standard gravitational theory is correct, then most of the matter in the universe is in an unidentified form which does not emit enough light to have been detected by current instrumentation. This proceedings was devoted to a discussion of the so-called "missing matter" problem in the universe. The goal of the School was to make current research work on unseen matter accessible to students of faculties without prior experience in this area. Due to the pedagogical nature of the School and the strong interactions between students and the lectures, the written lectures included in this volume often contain techniques and explanations not found in more formal journal publications.

This book is a collection of experimental studies demonstrating structure-function relationships in various biological systems having particular surface specialization to increase/decrease friction and adhesion. Studies on snake skin, adhesive pads, wing-interlocking devices and sticky mouthparts of insects as well as anti-adhesive and adhesive surfaces of plants are included in the volume containing four main subsections: (1) adhesion, (2) friction, (3) attachment-devices, (4) attachment-related behavior. Numerous experimental methods for characterizing tribological properties of biological surfaces at macro-, micro-, and nanoscale levels are demonstrated. This book is an excellent collection of publications on biotribology for both engineers and physicists working with biological systems as well as for biologists studying friction and adhesion. Inspirations from biology reported here may be also potentially interesting for biomimetics.

The workshop "From Dust to Terrestrial Planets" was initiated by a working group of planetary scientists invited to ISSI by Johannes Geiss in November 1997. The group split to focus on three topics, one of which was the history of the early solar system, including the formation of the terrestrial planets in the inner solar system. Willy Benz, Gunter Lugmair, and Frank Podosek were invited to convene planetary scientists, astrophysicists, and cosmochemists to synthesize the current knowledge on the origin and evolution of our inner planetary system. The convenors raised the interest of scientists from all over the world in the detailed assessment of the available astronomical, chronological, geochemical and dynamical constraints of the first period of inner solar system evolution. In partic ular, this included appraisal of the newest results from astronomical observations by the Hubble Space Telescope, the Infrared Space Observatory, and other space and ground-based facilities of solar-like systems and nebular disks, possibly repre senting early stages of the solar accretion disk and planet formation. At the same time, the current models of the origin, evolution, transport, and accretion processes of circum stellar disks were presented. This included the new insights provided by the recent discovery of extrasolar giant planets, which were considered insofar as they are relevant to the overall dynamics of the inner part of the solar system.

This volume contains the lectures presented at the first course of the Inter national School of Space Chemistry held in Erice (Sicily) from May 10 to May 20 at the 'E. Majorana Centre for Scientific Culture'. The course was attended by 57 participants from 11 countries. The recognition by Professor A. Zichichi that space chemistry is one of the important and rapidly growing scientific disciplines with many and varied appli cations provided the stimulation to initiate this new school. Historically, the study of chemistry in space had its major origins in comets, the solar nebula and circumstellar envelopes before the interstellar medium achieved its current prominence. A remarkably rapid development in interstellar chemistry was precipitated by the discovery of formaldehyde in the late 1960's made possible by the new radio observational techniques. A four atom molecule in interstellar space was indeed a surprise considering that only a short time ear lier there were still arguments about the existence of the simplest of all molecules - the hydrogen molecule. The application of ion-molecule reactions to interstellar cloud chemistry provided a rich variety of new possibilities which were, however, continuously under pressure to keep pace with radio-astronomical discoveries of more and more complex molecules."

The study of orbits in dynamical systems and the theory of order and chaos has progressed enormously over the last few decades. It thus became an essential tool in dynamical astronomy. The book is the first to provide a general overview of order and chaos in dynamical astronomy. The progress of the theory of chaos has a profound impact on galactic dynamics. It has even invaded celestial mechanics, since chaos was found in the solar system which in the past was considered as a prototype of order. The book provides a unifying approach to these topics from an author who has spent more than 50 years of research in the field. The first part treats order and chaos in general. The other two parts deal with order and chaos in galaxies and with other applications in dynamical astronomy, ranging from celestial mechanics to general relativity and cosmology. This book, addressing especially the astrophysics, is also written as a textbook on dynamical systems for students in physics.

A reissue of a classic book, intended for undergraduate courses in biophysics, biological physics, physiology, medical physics, and biomedical engineering. This is an introduction to mechanics, with examples and problems from the medical and biological sciences, covering standard topics of kinematics, dynamics, statics, momentum, and feedback, control and stability but with the emphasis on physical and biological systems. The book can be used as a supplement to standard introductory physics courses, as well as for medical schools, medical physics courses, and biology departments. The three volumes combined present all the major topics in physics. Originally published in 1974 from the authors typescript, this reissue will be edited, corrected, typeset, the art redrawn, and an index added, plus a solutions manual will also be available.

This book provides an overview of recent research highlights in the main areas of application of magnetic reconnection (MR), including planetary, solar and magnetospheric physics and astrophysics. It describes how research on magnetic reconnection, especially concerning the Earth's magnetosphere, has grown extensively due to dedicated observations from major satellite missions such as Cluster, Double Star and Themis. The accumulated observations from these missions are being supplemented by many theoretical and modelling efforts, for which large scale computer facilities are successfully being used, and the theoretical advances are also covered in detail. Opening with an introductory discussion of some fundamental issues related to magnetic reconnection, subsequent chapters address topics including collisionless magnetic reconnection, MHD structures in 3D reconnection, energy conversion processes, fast reconnection mediated by plasmoids, rapid reconnection and magnetic field topology. Further chapters consider specific areas of application such as magnetospheric dayside and tail reconnection, comparative reconnection in planetary systems and reconnection in astrophysical systems. The book offers insight into discussions about fundamental concepts and key aspects of MR, access to the full set of applications of MR as presently known in space physics and in astrophysics, and an introduction to a new related area of study dealing with the annihilation of quantum magnetic fluxes and its implications in the study on neutron star activity. The book is aimed primarily at students entering the field, but will also serve as a useful reference text for established scientists and senior researchers.

Geometrical Physics in Minkowski Spacetime is an overview and description of the geometry in spacetime, and aids in the creation and development of intuition in four-dimensional Minkowski space. The deepest understanding of relativity and spacetime is in terms of the geometrical absolutes, and this is what the book seeks to develop. The most interesting topics requiring special relativity are covered, including:SpacetimeVectors in SpacetimeElectromagnetismAsymptotic Momentum ConservationCovectors and Dyadics in SpacetimeEnergy Tensor Although the book is not meant for the complete beginner in special relativity, the mathematical prerequisites for the early chapters of the book are very few - linear algebra and elementary geometry (done using vectors and a scalar product). For the later chapters, multivariable calculus and ordinary differential equations are often needed.

This book focuses on important interfacial phenomena, such as interfacial potential and interfacial multi-functionality, responsible for determining the fate of nanoparticles inside the biological milieu. Additionally, this book explores the role of surface defects in photocatalytic nanoparticles in defining the nanoparticle interaction to biological membrane and cytotoxic propensity.The authors describe the interfacial assembly of peptide/protein on conformational/functional dynamics of the peptide/protein, which may be adopted as an approach to moderate the protein misfolding diseases.

An up-to-date account on the advancement in science and technology and the most recent developments on materials used for solar energy devices is presented with detailed description in the following areas: selective coating for heating and cooling; photovoltaic conversion and comparison among single crystalline silicon, concentrating cells and amorphous silicon and advance tendum coating for selective spectrum which can be used for greenhouse, homes and in energy conservation.

An up-to-date account on the advancement in science and technology and the most recent developments on materials used for solar energy devices is presented with detailed description in the following areas: selective coating for heating and cooling; photovoltaic conversion and comparison among single crystalline silicon, concentrating cells and amorphous silicon and advance tendum coating for selective spectrum which can be used for greenhouse, homes and in energy conservation.