Mechanics plays a central role in determining form and function in biology. This holds at the cellular, molecular and tissue scales. At the cellular scale, mechanics in?uences cell adhesion, cytoskeletal dynamics and the traction that the cell can generate on a given substrate. All of these in turn - fect the cellular functions of migration, mitosis, phagocytosis, endocytosis and stem cell differentiation among others. Indeed, if cells do not develop the appropriate stresses, they are unviable and die. These aspects of cell mechanics are frequently used by mainstream biologists, as traditional mechanicians may be surprised to learn. There is a growing view that many functions of the cell are mechanical in nature even though chemical signals play crucial roles in the processes. Free energy barriers control transitions between different conformations of vir- ally every macromolecule including DNA, RNA, the adhesion protein integrin, the motor protein myosin, and the proteins vinculin and talin that link the cytoskeleton to focal adhesions. The strain energy can be a signi?cant component of the total free energy barrier. For binding to take place, the macromolecules need to be in conf- mational states that expose chemical groups without steric hinderance. The kinetics of chemical reactions are therefore strongly in?uenced by the conformational strain energy.

This book addresses the subject of gravity theories in two and three spacetime dimensions. The prevailing philosophy is that lower dimensional models of gravity provide a useful arena for developing new ideas and insights, which are applicable to four dimensional gravity. The first chapter consists of a comprehensive introduction to both two and three dimensional gravity, including a discussion of their basic structures. In the second chapter, the asymptotic structure of three dimensional Einstein gravity with a negative cosmological constant is analyzed. The third chapter contains a treatment of the effects of matter sources in classical two dimensional gravity. The fourth chapter gives a complete analysis of particle pair creation by electric and gravitational fields in two dimensions, and the resulting effect on the cosmological constant. Lower dimensional gravity may have never been reviewed in its entirety anywhere in the literature.

Anyone who has experienced turbulence in flight knows that it is usually not pleasant, and may wonder why this is so difficult to avoid. The book includes papers by various aviation turbulence researchers and provides background into the nature and causes of atmospheric turbulence that affect aircraft motion, and contains surveys of the latest techniques for remote and in situ sensing and forecasting of the turbulence phenomenon. It provides updates on the state-of-the-art research since earlier studies in the 1960s on clear-air turbulence, explains recent new understanding into turbulence generation by thunderstorms, and summarizes future challenges in turbulence prediction and avoidance.

This book introduces the basic theoretical concepts required for the analysis of the optical response of semiconductor systems in the coherent regime. It is the most instructive textbook on the theory and optical effects of semiconductors. The entire presentation is based on a one-dimensional tight-binding model. Starting with discrete-level systems, increasing complexity is added gradually to the model by including band-structure and many-particle interaction. Various linear and nonlinear optical spectra and temporal phenomena are studied. The analysis of many-body effects in nonlinear optical phenomena covers a major part of the book.

This book is a collection of experimental studies demonstrating structure-function relationships in various biological systems having particular surface specialization to increase/decrease friction and adhesion. Studies on snake skin, adhesive pads, wing-interlocking devices and sticky mouthparts of insects as well as anti-adhesive and adhesive surfaces of plants are included in the volume containing four main subsections: (1) adhesion, (2) friction, (3) attachment-devices, (4) attachment-related behavior. Numerous experimental methods for characterizing tribological properties of biological surfaces at macro-, micro-, and nanoscale levels are demonstrated. This book is an excellent collection of publications on biotribology for both engineers and physicists working with biological systems as well as for biologists studying friction and adhesion. Inspirations from biology reported here may be also potentially interesting for biomimetics.

The need for tsunami research and analysis has grown dramatically following the devastating tsunami of December 2004, which affected Southern Asia. This book pursues a detailed theoretical and mathematical analysis of the fundamentals of tsunamis, especially the evolution and dynamics of tsunamis and other great waves. Of course, it includes specific measurement results from the 2004 tsunami, but the emphasis is on the nature of the waves themselves and their links to nonlinear phenomena.

This volume describes the state-of-knowledge in the study of the relationships between mechanical loading states in tissues and common pathophysiologies related to increase in mass of adipose tissues and/or hyperglycemia which eventually lead to obesity, diabetes, insulin resistance, hyperlipidemia, metabolic inflammations, certain types of cancer and other related diseases. There appears to be an interaction between the loading states in tissues and cells and these chronic conditions, as well as with factors such as age, gender and genetics of the individual. Bioengineering has made key contributions to this research field in providing technologies for cell biomechanics experimentation, microscopy and image processing, tissue engineering and multi-scale, multi-physics computational modeling. Topics at the frontier of this field of study include: the continuous monitoring of cell growth, proliferation and differentiation in response to mechanical factors such as stiffness of the extracellular matrix (ECM) and mechanical loads transferred through the ECM; mechanically-activated signaling pathways and molecular mechanisms; effects of different loading regimes and mechanical environments on differentiation fates of mesenchymal stem cells (MSCs) into myogenic and osteogenic versus adipogenic lineages; the interactions between nutrition and mechanotransduction; cell morphology, focal adhesion patterns and cytoskeletal remodeling changes in adipogenesis; activation of receptors related to diabetes by mechanical forces; brown and white adipose plasticity and its regulation by mechanical factors.

If standard gravitational theory is correct, then most of the matter in the universe is in an unidentified form which does not emit enough light to have been detected by current instrumentation. This proceedings was devoted to a discussion of the so-called "missing matter" problem in the universe. The goal of the School was to make current research work on unseen matter accessible to students of faculties without prior experience in this area. Due to the pedagogical nature of the School and the strong interactions between students and the lectures, the written lectures included in this volume often contain techniques and explanations not found in more formal journal publications.

If standard gravitational theory is correct, then most of the matter in the universe is in an unidentified form which does not emit enough light to have been detected by current instrumentation. This proceedings was devoted to a discussion of the so-called "missing matter" problem in the universe. The goal of the School was to make current research work on unseen matter accessible to students of faculties without prior experience in this area. Due to the pedagogical nature of the School and the strong interactions between students and the lectures, the written lectures included in this volume often contain techniques and explanations not found in more formal journal publications.

This volume contains the lectures presented at the first course of the Inter national School of Space Chemistry held in Erice (Sicily) from May 10 to May 20 at the 'E. Majorana Centre for Scientific Culture'. The course was attended by 57 participants from 11 countries. The recognition by Professor A. Zichichi that space chemistry is one of the important and rapidly growing scientific disciplines with many and varied appli cations provided the stimulation to initiate this new school. Historically, the study of chemistry in space had its major origins in comets, the solar nebula and circumstellar envelopes before the interstellar medium achieved its current prominence. A remarkably rapid development in interstellar chemistry was precipitated by the discovery of formaldehyde in the late 1960's made possible by the new radio observational techniques. A four atom molecule in interstellar space was indeed a surprise considering that only a short time ear lier there were still arguments about the existence of the simplest of all molecules - the hydrogen molecule. The application of ion-molecule reactions to interstellar cloud chemistry provided a rich variety of new possibilities which were, however, continuously under pressure to keep pace with radio-astronomical discoveries of more and more complex molecules."

This volume focuses on latest research in therapeutic devices for cardiovascular, i.e. vascular and valvular and cardiac diseases. In the area of vascular therapies, aspects covered relate to latest research in small-diameter tissue-regenerative vascular grafts, one of the greatest persisting challenges in cardiovascular therapies, stent grafts and endovascular stents for percutaneous arterial interventions. Contributions on valvular therapies focus on tissue engineered and tissue regenerative prosthetic heart valves and valvular prostheses for trans-apical implantation including the challenges posed on the prosthesis design. The section on cardiac diseases aims at covering therapeutic advances for myocardial infarction and prevention of heart failure and on in vivo biomechanics of implantable cardiac pacemaker devices. A further section complements these three areas by presenting constitutive modelling of soft biological tissues of the cardiovascular system, an area imperative for advanced numerical and computational modelling in the development and optimisation of cardiovascular devices and therapies.

The study of orbits in dynamical systems and the theory of order and chaos has progressed enormously over the last few decades. It thus became an essential tool in dynamical astronomy. The book is the first to provide a general overview of order and chaos in dynamical astronomy. The progress of the theory of chaos has a profound impact on galactic dynamics. It has even invaded celestial mechanics, since chaos was found in the solar system which in the past was considered as a prototype of order. The book provides a unifying approach to these topics from an author who has spent more than 50 years of research in the field. The first part treats order and chaos in general. The other two parts deal with order and chaos in galaxies and with other applications in dynamical astronomy, ranging from celestial mechanics to general relativity and cosmology. This book, addressing especially the astrophysics, is also written as a textbook on dynamical systems for students in physics.

This book provides an overview of recent research highlights in the main areas of application of magnetic reconnection (MR), including planetary, solar and magnetospheric physics and astrophysics. It describes how research on magnetic reconnection, especially concerning the Earth's magnetosphere, has grown extensively due to dedicated observations from major satellite missions such as Cluster, Double Star and Themis. The accumulated observations from these missions are being supplemented by many theoretical and modelling efforts, for which large scale computer facilities are successfully being used, and the theoretical advances are also covered in detail. Opening with an introductory discussion of some fundamental issues related to magnetic reconnection, subsequent chapters address topics including collisionless magnetic reconnection, MHD structures in 3D reconnection, energy conversion processes, fast reconnection mediated by plasmoids, rapid reconnection and magnetic field topology. Further chapters consider specific areas of application such as magnetospheric dayside and tail reconnection, comparative reconnection in planetary systems and reconnection in astrophysical systems. The book offers insight into discussions about fundamental concepts and key aspects of MR, access to the full set of applications of MR as presently known in space physics and in astrophysics, and an introduction to a new related area of study dealing with the annihilation of quantum magnetic fluxes and its implications in the study on neutron star activity. The book is aimed primarily at students entering the field, but will also serve as a useful reference text for established scientists and senior researchers.

A reissue of a classic book, intended for undergraduate courses in biophysics, biological physics, physiology, medical physics, and biomedical engineering. This is an introduction to mechanics, with examples and problems from the medical and biological sciences, covering standard topics of kinematics, dynamics, statics, momentum, and feedback, control and stability but with the emphasis on physical and biological systems. The book can be used as a supplement to standard introductory physics courses, as well as for medical schools, medical physics courses, and biology departments. The three volumes combined present all the major topics in physics. Originally published in 1974 from the authors typescript, this reissue will be edited, corrected, typeset, the art redrawn, and an index added, plus a solutions manual will also be available.

The present 15th volume of the ISSI Space Science Series is devoted to Auroral Plasma Physics. The aurora is arguably the most intriguing phenomenon in space plasma physics. Not only is it the most spectacular manifestation of the Sun-Earth connection chain, but the underlying plasma processes are expected to be ubiqui- tous in the plasma universe. Recognizing the enormous progress made over the last decade in the understanding of the physics of the auroral acceleration processes, it seemed timely to write a comprehensive and integrated book on the subject. Re- cent advances concern the clarification of the nature of the acceleration process of the electrons that are responsible for the visible aurora, the recognition of the fundamental role of the large-scale current systems in organizing the auroral mor- phology, and of the interplay between particles and electromagnetic fields. The project began in March 1999, as a natural follow-up of the project on Magnetospheric Plasma Sources and Losses that resulted in volume 6 of this se- ries, with a planning meeting by a core-group that coordinated the project. The group consisted of J. E. Borovsky, Los Alamos National Laboratory; C. W. Carl- son, University of California, Berkeley; G. Haerendel, Max-Planck-Institut fur ex- traterrestrische Physik, Garching; B. Hultqvist, Swedish Intitute ofSpace Physics, H. E. J. Koskinen, Finnish Meteorological Institute, Helsinki; W. Lotko, Kiruna; Dartmouth College, Hanover, New Hampshire; K. A. Lynch, University of New Hampshire, Durham and G. Marklund, Royal Institute ofTechnology, Stockholm. G. Paschmann, ISSI, Bern, was the project leader.

An up-to-date account on the advancement in science and technology and the most recent developments on materials used for solar energy devices is presented with detailed description in the following areas: selective coating for heating and cooling; photovoltaic conversion and comparison among single crystalline silicon, concentrating cells and amorphous silicon and advance tendum coating for selective spectrum which can be used for greenhouse, homes and in energy conservation.

An up-to-date account on the advancement in science and technology and the most recent developments on materials used for solar energy devices is presented with detailed description in the following areas: selective coating for heating and cooling; photovoltaic conversion and comparison among single crystalline silicon, concentrating cells and amorphous silicon and advance tendum coating for selective spectrum which can be used for greenhouse, homes and in energy conservation.

Infrared astronomy has undergone an enormous revolution during the last decade. Despite the great technical difficulties of building detectors in a cryogenic environment, the scientific advances in infrared astronomy have been astounding. In the near future many more advances can be expected from still newer developments in telescope and detector designs. High quality detector arrays and passively cooled telescopes are very promising techniques for achieving considerably larger apertures. This volume contains the refereed papers from the workshop on 'Next Generation Infrared Observatory', dealing with all new aspects of future infrared telescopes.

The workshop "From Dust to Terrestrial Planets" was initiated by a working group of planetary scientists invited to ISSI by Johannes Geiss in November 1997. The group split to focus on three topics, one of which was the history of the early solar system, including the formation of the terrestrial planets in the inner solar system. Willy Benz, Gunter Lugmair, and Frank Podosek were invited to convene planetary scientists, astrophysicists, and cosmochemists to synthesize the current knowledge on the origin and evolution of our inner planetary system. The convenors raised the interest of scientists from all over the world in the detailed assessment of the available astronomical, chronological, geochemical and dynamical constraints of the first period of inner solar system evolution. In partic ular, this included appraisal of the newest results from astronomical observations by the Hubble Space Telescope, the Infrared Space Observatory, and other space and ground-based facilities of solar-like systems and nebular disks, possibly repre senting early stages of the solar accretion disk and planet formation. At the same time, the current models of the origin, evolution, transport, and accretion processes of circum stellar disks were presented. This included the new insights provided by the recent discovery of extrasolar giant planets, which were considered insofar as they are relevant to the overall dynamics of the inner part of the solar system.

Interesting and often unexpected achievements of the mechanics of space flight throw a new light onto several classical problems. The book 's emphasis is on analysis carried out on the level of graphs and drawings, and sometimes numbers, revealing the beauty of the research process leading to the results.

The Swiss Society for Astrophysics and Astronomy organizes each year in the late winter or early spring an advanced course. The format of the school is always iden tical: three leading lecturers are invited to cover the subject in nine or ten lectures each and to deliver a written version of their lecture notes. Lectures are held in the morning and late afternoon, thus leaving ample time for discussion and skiing. These arrangements prove very convivial and lead to an excellent atmosphere in which to learn exciting new subjects and establish contacts with colleagues. A wide variety of people attend the school, including many young students, mostly from Europe, and some experienced researchers. The 20th Advanced Course of the Swiss Society for Astrophysics and Astronomy took place in Les Diablerets from 1 to 6 April 1990. It was devoted to observational and theoretical aspects of active galactic nuclei. The previous advanced courses of the Swiss Society for Astrophysics and Astronomy have regularly taken place in Saas-Fee, a small resort in the Swiss Alps, hence the name "Saas-Fee" used to de scribe the courses and lecture notes. In the last three years, however, the course was organized in Leysin and in Les Diablerets, both also situated in the Swiss Alps."

Laser measurement technology has evolved in the last years in a versatile and reflationary way. Today, its methods are indispensable for research and development activities as well as for production technology. Every physicist and engineer should therefore gain a working knowledge of laser measurement technology.

This book closes the gap of existing textbooks. It introduces in a comprehensible presentation laser measurement technology in all its aspects. Numerous figures, graphs and tables allow for a fast access into the matter. In the first part of the book the important physical and optical basics are described being necessary to understand laser measurement technology. In the second part technically significant measuring methods are explained and application examples are presented.

Target groups of this textbook are students of natural and engineering sciences as well as working physicists and engineers, who are interested to make themselves familiar with laser measurement technology and its fascinating potentials.

Geometrical Physics in Minkowski Spacetime is an overview and description of the geometry in spacetime, and aids in the creation and development of intuition in four-dimensional Minkowski space. The deepest understanding of relativity and spacetime is in terms of the geometrical absolutes, and this is what the book seeks to develop. The most interesting topics requiring special relativity are covered, including:SpacetimeVectors in SpacetimeElectromagnetismAsymptotic Momentum ConservationCovectors and Dyadics in SpacetimeEnergy Tensor Although the book is not meant for the complete beginner in special relativity, the mathematical prerequisites for the early chapters of the book are very few - linear algebra and elementary geometry (done using vectors and a scalar product). For the later chapters, multivariable calculus and ordinary differential equations are often needed.

At the opening of the "Third Meeting on Celestial Mechanics - CELMEC III", strong sensations hit our minds. The conference (18-22 June 2001) was being held in Villa Mondragone, a beautiful complex of buildings and gardens located within the township of Monte Porzio Catone, on the hills surrounding Rome. A former papal residence, the building has been recently restored by the University of Rome "Tor Vergata" to host academic activities and events. The conference room is called "Salone degli Svizzeri": here, Gregory XIII, on February 24, 1582, gave its sanction to the reform of the Julian calendar and declared officially in use the calendar still adopted nowadays. The magnificent high walls and tall ceiling strongly resounded, giving to our voice a peculiar Vatican sound, which took us by surprise. May be - we thought - a distant echo of the very words of Gregory XIII proclaiming the modem calendar was still haunting the room. Around us, in the audience, many countries were represented, thus indicating that the idea of putting together the three "souls" of modem Celestial Mechanics - perturbation theories, solar and stellar system studies, spaceflight dynamic- had been successful. CELMEC III is in fact the latest of a series of meetings (the first two editions took place in 1993 and 1997 in L' Aquila, Italy) whose aim is to establish a common ground among people working in Celestial Mechanics, yet belonging to different institutions such as universities, astronomical observatories, research institutes, space agencies and industries.