This book uses new data from the very low radio frequency telescope LOFAR to analyse the magnetic structure in the giant radio galaxy NGC6251. This analysis reveals that the magnetic field strength in the locality of this giant radio galaxy is an order of magnitude lower than in other comparable systems. Due to the observational limitations associated with capturing such huge astrophysical structures, giant radio galaxies are historically a poorly sampled population of objects; however, their preferential placement in the more rarefied regions of the cosmic web makes them a uniquely important probe of large-scale structures. In particular, the polarisation of the radio emissions from giant radio galaxies is one of the few tools available to us that can be used to measure magnetic fields in regions where the strength of those fields is a key differentiator for competing models of the origin of cosmic magnetism. Low frequency polarisation data are crucial for detailed analyses of magnetic structure, but they are also the most challenging type of observational data to work with. This book presents a beautifully coupled description of the technical and scientific analysis required to extract valuable information from such data and, as the new generation of low frequency radio telescopes reveals the larger population of giant radio galaxies, it offers a significant resource for future analyses.

This book on space geodesy presents pioneering geometrical approaches in the modelling of satellite orbits and gravity field of the Earth, based on the gravity field missions CHAMP, GRACE and GOCE in the LEO orbit. Geometrical approach is also extended to precise positioning in space using multi-GNSS constellations and space geodesy techniques in the realization of the terrestrial and celestial reference frame of the Earth. This book addresses major new developments that were taking place in space geodesy in the last decade, namely the availability of GPS receivers onboard LEO satellites, the multitude of the new GNSS satellite navigation systems, the huge improvement in the accuracy of satellite clocks and the revolution in the determination of the Earth's gravity field with dedicated satellite missions.

The investigation of discrete symmetries is a fascinating subject which has been central to the agenda of physics research for 50 years, and has been the target of many experiments, ongoing and in preparation, all over the world. This book approaches the subject from a somewhat less traditional angle: while being self-contained and suitable to the reader who wants to acquire a solid knowledge of the topic, it puts more emphasis on the experimental aspects of the field, trying to provide a wider picture than usual and to convey the intellectual challenge of experimental physics. The book includes the related connection to phenomenology, a purpose for which the precision experiments in this field - often rather elegant and requiring a good amount of ingenuity - are very well suited. The book discusses discrete symmetries (parity, charge conjugation, time reversal, and of course CP symmetry) in microscopic (atomic, nuclear, and particle) physics, and includes the detailed description of some key or representative experiments. The book discusses their principles and challenges more than the historical development. The main past achievements and the most recent developments are both included. The level goes from introductory to advanced. While mainly addressed to graduate students, the book can also be useful to undergraduates (by skipping some of the more advanced sections, and utilizing the brief introductions to some topics in the appendices), and to young researchers looking for a wider modern overview of the issues related to CP symmetry.

This thesis focuses on the very high Mach number shock wave that is located sunward of Saturn's strong magnetic field in the continuous high-speed flow of charged particles from the Sun (the solar wind). The author exploits the fact that the Cassini spacecraft is the only orbiter in a unique parameter regime, far different from the more familiar near-Earth space, to provide in-situ insights into the unreachable exotic regime of supernova remnants. This thesis bridges the gap between shock physics in the Solar System and the physics of ultra-high Mach number shocks around the remnants of supernova explosions, since to date research into the latter has been restricted to theory, remote observations, and simulations.

This book presents the first overview of the composition and structure of the Earth's lower mantle. The first part focuses on the study of lower-mantle minerals, identified as inclusions in diamonds from different regions of the world. Three associations are established among the lower-mantle minerals: ultramafic, mafic, and carbonatic. The carbonatic association is of particular interest because it characterizes the media of natural diamond formation. In turn, the second part analyzes the structure of the lower mantle, revealing its heterogeneous composition. It is based on the results of experiments demonstrating phase transitions in lower-mantle minerals, and on seismological data. Deep-seated earthquakes point to the presence within the lower mantle of numerous seismic boundaries caused by mineral structure transitions. In closing, the last part of the book compares observed data with experimental data, highlighting several discrepancies that indicate Earth may have a more complex planetary history than previously assumed, and examining its primarily non-chondritic composition.

Of Clocks and Time takes readers on a five-stop journey through the physics and technology (and occasional bits of applications and history) of timekeeping. On the way, conceptual vistas and qualitative images abound, but since mathematics is spoken everywhere the book visits equations, quantitative relations, and rigorous definitions are offered as well. The expedition begins with a discussion of the rhythms produced by the daily and annual motion of sun, moon, planets, and stars. Centuries worth of observation and thinking culminate in Newton's penetrating theoretical insights since his notion of space and time are still influential today. During the following two legs of the trip, tools are being examined that allow us to measure hours and minutes and then, with ever growing precision, the tiniest fractions of a second. When the pace of travel approaches the ultimate speed limit, the speed of light, time and space exhibit strange and counter-intuitive traits. On this fourth stage of the journey, Einstein is the local tour guide whose special and general theories of relativity explain the behavior of clocks under these circumstances. Finally, the last part of the voyage reverses direction, moving ever deeper into the past to explore how we can tell the age of "things" - including that of the universe itself.

This book lays the foundations of gas- and fluid dynamics.The basic equations are developed from first principles, building on the (assumed) knowledge of Classical Mechanics. This leads to the discussion of the mathematical properties of flows, conservation laws, perturbation analysis, waves and shocks. Most of the discussion centers on ideal (frictionless) fluids and gases. Viscous flows are discussed when considering flows around obstacles and shocks. Many of the examples used to illustrate various processes come from astrophysics and geophysical phenomena.

This thesis addresses two very different but equally important topics in the very broad fields of astrophysics and cosmology: (I) the generation of cosmological magnetic fields and (II) gravitational fragmentation of the Cosmic Web. All mathematical developments are completed by illuminating physical interpretations, and the thesis, which is guided by existing observations, is purely theoretical. In part I, the author further develops a magnetogenesis model proposed in the literature, providing an unprecedented level of physical understanding. He demonstrates that the physics of photoionisation is very likely to have premagnetised, at a relevant level, the entire Universe at the early epoch of the formation of the first luminous sources. In part II, the author adapts the tools of plasma spectral theory to the context of gravitational instability of the baryonic gas within the stratified structures of the Cosmic Web. He skillfully derives the wave equation governing the growth of perturbations and explores various equilibrium configurations, in planar and cylindrical geometries characteristic of cosmic walls and filaments, for isothermal and polytropic conditions, with or without an external gravitational background. Clearly structured and written in pedagogical style, this outstanding thesis puts the results into perspective and highlights the merits and limitations of the various approaches explored.

This prizewinning PhD thesis presents a general discussion of the orbital motion close to solar system small bodies (SSSBs), which induce non-central asymmetric gravitational fields in their neighborhoods. It introduces the methods of qualitative theory in nonlinear dynamics to the study of local/global behaviors around SSSBs. Detailed mechanical models are employed throughout this dissertation, and specific numeric techniques are developed to compensate for the difficulties of directly analyzing. Applying this method, several target systems, like asteroid 216 Kleopatra, are explored in great detail, and the results prove to be both revealing and pervasive for a large group of SSSBs.

In his PhD dissertation Martin Bo Nielsen performs observational studies of rotation in stars like the Sun. The interior rotation in stars is thought to be one of the driving mechanisms of stellar magnetic activity, but until now this mechanism was unconstrained by observational data. NASA's Kepler space mission provides high-precision observations of Sun-like stars which allow rotation to be inferred using two independent methods: asteroseismology measures the rotation of the stellar interior, while the brightness variability caused by features on the stellar surface trace the rotation of its outermost layers. By combining these two techniques Martin Bo Nielsen was able to place upper limits on the variation of rotation with depth in five Sun-like stars. These results suggest that the interior of other Sun-like stars also rotate in much the same way as our own Sun.

This book is an in-depth treatment of the theoretical background relevant to an understanding of materials that can be obtained by using high-energy electron diffraction and microscopy.

This thesis describes novel substrate embedded physical sensors that can be used to monitor different types of cell-based assays non-invasively and label-free. The sensors described provide integrative information of the cells under study with an adaptable time resolution (ranging from milliseconds to days). This information about the dynamic cell response to chemical, physical or biological stimuli defines a new paradigm in fundamental biomedical research. The author, Maximilian Oberleitner, describes approaches in which the cells are directly grown on different sensor surfaces (gold-film electrodes, shear wave resonators or dye-doped polymer films). This approach, with the reacting cells in particularly close proximity and contact with the sensor surface, is key to a remarkable sensitivity, opening the way for a variety of new applications. This thesis not only introduces the fundamentals of each approach, but it also describes in great detail the design principles and elucidates the boundary conditions of the new sensors.

Explores the many facets of redox exchanges that drive magma's behavior and evolution, from the origin of the Earth until today The redox state is one of the master variables behind the Earth's forming processes, which at depth concern magma as the major transport agent. Understanding redox exchanges in magmas is pivotal for reconstructing the history and compositional make-up of our planet, for exploring its mineral resources, and for monitoring and forecasting volcanic activity. Magma Redox Geochemistry describes the multiple facets of redox reactions in the magmatic realm and presents experimental results, theoretical approaches, and unconventional and novel techniques. Volume highlights include: Redox state and oxygen fugacity: so close, so far Redox processes from Earth's accretion to global geodynamics Redox evolution from the magma source to volcanic emissions Redox characterization of elements and their isotopes The American Geophysical Union promotes discovery in Earth and space science for the benefit of humanity. Its publications disseminate scientific knowledge and provide resources for researchers, students, and professionals.

This book focuses on the mechanobiological principles in tissue engineering with a particular emphasis on the multiscale aspects of the translation of mechanical forces from bioreactors down to the cellular level. The book contributes to a better understanding of the design and use of bioreactors for tissue engineering and the use of mechanical loading to optimize in vitro cell culture conditions. It covers experimental and computational approaches and the combination of both to show the benefits that computational modelling can bring to experimentalists when studying in vitro cell culture within a scaffold. With topics from multidisciplinary fields of the life sciences, medicine, and engineering, this work provides a novel approach to the use of engineering tools for the optimization of biological processes and its application to regenerative medicine. The volume is a valuable resource for researchers and graduate students studying mechanobiology and tissue engineering. For undergraduate students it also provides deep insight into tissue engineering and its use in the design of bioreactors. The book is supplemented with extensive references for all chapters to help the reader to progress through the study of each topic.

The work describes the production technology of standard medical radionuclides using reactors and cyclotrons for patient diagnosis and therapy. A special focus lies on the science and technology involved in the development of novel radionuclides for positron emission tomography (PET) and internal targeted radiotherapy. The availability of those radionuclides is opening up new potential in clinical research, especially in neurology, cardiology and oncology. The future perspectives of the developing technology are also discussed.

In this provocative text, a noted neuroscientist reexamines Freud's posthumously published Project of Scientific Psychology in the light of modern neuroscience. This expanded "thermodynamics of the mind" model includes robust conceptions of the cellular and neural processes that accompany creation of consciousness and memory, their contributions to such conditions as depression, dissociative disorders, and schizophrenia, and implications for practice, from imaging to talk-based therapies to pharmacotherapy. Central to this construct is Freud's proposal of specific "omega" neurons as the most volatile carriers of consciousness between mind and brain, which is applied to current issues regarding complexity and executive functioning. In addition, the book is extensively referenced, allowing readers to investigate these and related phenomena in greater detail. Among the topics covered: Neural reductionism in Freud's "Project" and neuropsychoanalysis. Thermodynamics and brain self-organization. Conflicting information and the dissociated mind. The Cartesian model of the mind and the binding problem. Neuroendocrine and immune response to stress. The concept of omega neurons and modern chaos theory. Rigorous, challenging, and occasionally startling, The Brain and Conscious Unity is a milestone in the neuroscience and mind/brain literature to be read and discussed by psychiatrists, psychologists, and neuropsychologists.

This thesis describes the application of a Monte Carlo radiative transfer code to accretion disc winds in two types of systems spanning 9 orders of magnitude in mass and size. In both cases, the results provide important new insights. On small scales, the presence of disc winds in accreting white dwarf binary systems has long been inferred from the presence of ultraviolet absorption lines. Here, the thesis shows that the same winds can also produce optical emission lines and a recombination continuum. On large scales, the thesis constructs a simple model of disc winds in quasars that is capable of explaining both the observed absorption and emission signatures - a crucial advance that supports a disc-wind based unification scenario for quasars. Lastly, the thesis also includes a theoretical investigation into the equivalent width distribution of the emission lines in quasars, which reveals a major challenge to all unification scenarios.

This books provides up-to-date reviews on current advances of the role of HSP in veterinary medicine and research. Key basic and clinical research laboratories from major universities, veterinary hospitals and pharmaceutical companies around the world have contributed chapters that review present research activity and importantly project this field into the future. For easy readability, the book is sub divided into sections on HSP in the following aspects of Veterinary Medicine, including, I - Domestic Animals, II - Poultry, III - Aquatic and IV - Parasites. The book is a must read for heat shock protein researchers in general and specifically those involved in clinical and research in veterinary medicine.

This volume comprises the latest developments in both fundamental science and patient-specific applications, discussing topics such as: cellular mechanics; injury biomechanics; biomechanics of heart and vascular system; medical image analysis; and both patient-specific fluid dynamics and solid mechanics simulations. With contributions from researchers world-wide, the Computational Biomechanics for Medicine series of titles provides an opportunity for specialists in computational biomechanics to present their latest methodologies and advancements.

This volume presents different studies carried out on induced seismicity, both from experimental and theoretical viewpoints. Several examples of seismic activity induced by underground nuclear explosions, impoundment of artificial reservoirs, and mining activities are given and discussed. Another important subject which is covered is earthquakes induced by other large earthquakes. Further, tectonic stress release in the immediate vicinity of an underground nuclear explosion is treated. The release produces aftershocks of small magnitude, usually for several weeks, occurring a few kilometers within the shot point. This phenomenon is of importance in the context of monitoring a Comprehensive Test Ban Treaty.

This book presents various examples of how advanced fluorescence and spectroscopic analytical methods can be used in combination with computer data processing to address different biochemical questions. The main focus is on evolutionary biochemistry and the description of biochemical and metabolic issues; specifically, the use of pulse amplitude modulated fluorescence (PAM) for the functional analysis of the cellular state, as well as results obtained by means of the derivative spectroscopy method characterizing structural reorganization of a cell under the influence of external factors, are discussed. The topics presented here will be of interest to biologists, geneticists, biophysicists and biochemists, as well as experts in analytical chemistry, pharmaceutical chemistry and radio chemistry and radio activation studies with protonen and alpha-particles. It also offers a valuable resource for advanced undergraduate and graduate students in biological, physical and chemical disciplines whose work involves derivative spectrophotometry and PAM-fluorescence.

This detailed book systematically investigates subsurface geological fractures using rock mechanics, geology, and geophysics. Based on geological fracture mechanisms and fracture boundary conditions, it presents new finite-difference equations for the simulation of seismic wave responses to geological fractures, and proposes innovative AVO inversion equations for the accurate estimation of the rock properties of the fractured medium. It employs schematics, snapshots, color images and charts to demonstrate the mechanical characteristics of the fractures, the seismic wave-field response to the fractures, the seismic data attributes of the fractures and the rock properties of the fractures obtained via inversion. It provides a new methodology for enhancing geological fracture detection technology and for the accurate delineation of fractured reservoirs that ultimately benefits reservoir and mining engineers, geologists and geophysicists in terms of optimizing reservoir recovery, well performance and mining safety.

This book describes modern biophysical techniques that enable us to understand and examine dynamic processes of infection at the molecular level. Cutting-edge research articles, laboratory protocols, case studies and up-to-date reviews cover topics such as single-molecule observation of DNA replication repair pathways in E. coli; evolution of drug resistance in bacteria; restriction enzymes as barriers to horizontal gene transfer in Staphylococcus aureus; infectious and bacterial pathogen biofilms; killing infectious pathogens through DNA damage; bacterial surfaces in host-pathogen interactions; bacterial gene regulation by riboswitches; transcription regulation in enterobacterial pathogens; the bacterial flagellar motor; initial surface colonization by bacteria; Salmonella Typhi host restrictions; as well as monitoring proton motive force in bacteria; microbial pathogens using digital holography; mathematical modelling of microbial pathogen motility; neutron reflectivity in studying bacterial membranes; force spectroscopy in studying infection and 4D multi-photon imaging to investigate immune responses. The focus is on the development and application of complex techniques and protocols at the interface of life sciences and physics, which increase the physiological relevance of biophysical investigations.

This book is a passionate account of the scientific breakthroughs that led to the solution of the first protein structures and to the understanding of their function at atomic resolution. The book is divided into self-standing chapters that each deal with a protein or protein family. The subject is presented in a fluid, non-technical style that will engage student and scientists in biochemistry, biophysics, molecular and structure biology and physiology.

This thesis explores fluid distribution along the Nankai-Trough megathrust fault around the Kii Peninsula of Japan, where devastating earthquakes are expected to occur in the near future. Exploring fluid distribution along subduction zones is an important issue because the fluid is considered to control the occurrence of earthquakes. One of the effective strategies to estimate fluid content is retrieving receiver functions (RFs) from seismograms, but in the case of ocean-bottom seismometers (OBSs), noisy P-wave reverberations within the seawater column make such an analysis difficult. The author therefore developed a novel technique to suppress the water reverberations, which allows obtaining the fluid distribution data along a wide depth range on the plate interface. This thesis first presents the new technique, called the water layer filter method, and demonstrates its efficiency by using both synthetic and observation data. Then, using the method, a receiver function image of the Philippine Sea Plate is constructed to reveal dehydration processes of the subducting oceanic crust around the Kii Peninsula. Finally, the author performs high-frequency receiver function inversion analysis. The results indicate the presence of a thin fluid-rich sediment layer along the megathrust fault off the Kii Peninsula that acts as a pathway of fluid. Nowadays, the number of offshore observations is increasing worldwide. In this respect, the attempt to better analyze OBS data employing the new method will become more important in future studies.