This book addresses the mechanism of enrichment of heavy elements in galaxies, a long standing problem in astronomy. It mainly focuses on explaining the origin of heavy elements by performing state-of-the-art, high-resolution hydrodynamic simulations of dwarf galaxies. In this book, the author successfully develops a model of galactic chemodynamical evolution by means of which the neutron star mergers can be used to explain the observed abundance pattern of the heavy elements synthesized by the rapid neutron capture process, such as europium, gold, and uranium in the Local Group dwarf galaxies. The book argues that heavy elements are significant indicators of the evolutionary history of the early galaxies, and presents theoretical findings that open new avenues to understanding the formation and evolution of galaxies based on the abundance of heavy elements in metal-poor stars.

Prior to the 1920s it was generally thought, with a few exceptions, that our galaxy, the Milky Way, was the entire universe. Based on the work of Henrietta Leavitt with Cepheid variables, astronomer Edwin Hubble was able to determine that others had to lie outside our own. This books looks at 60 of those that possess some unusual qualities that make them of particular interest, from supermassive black holes and colliding galaxies to powerful radio sources.

This volume explores how ionic liquids are used in different areas of biotechnology. It also provides insights on the interaction of ionic liquids with biomolecules and biomaterials. Ionic liquids have become essential players in the fields of synthesis, catalysis, extraction and electrochemistry, and their unique properties have opened a wide range of applications in biotechnology. Readers will discover diverse examples of the application of ionic liquids as solvents for biomaterials extraction and pretreatment, in enzymatic and whole cell catalysed reaction, and as activation agents for biocatalysis. Particular attention is given to the biologically functionalized ionic liquids employed in medical and pharmaceutical applications. Although ionic liquids are considered "green solvents", the contributing authors will also explore their environmental impact when applied to biotechnology. Chemical, biological and medical scientists interested in ionic liquids and biotechnology will find this work instructive and informative.

In the field of particle and astrophysics one of the major unresolved problems is to understand the nature and properties of dark matter, which constitutes almost 80% of the matter content of the universe. This book gives a pedagogical introduction to the field of dark matter in general, and in particular to the model building perspective. This book focuses on teaching the basic tools for model building of dark matter, and it aims to motivate the reader to propose a new dark matter model.

This thesis provides new insights into the seemingly anomalous ubiquity of lithium-rich red giant stars. The theory of stellar evolution, one of the most successful models of modern astrophysics, predicts that red giant stars should display negligible levels of lithium (Li) on their surfaces. However, Li-rich giants, defined as those showing more than three times the Li content of the Sun, are found everywhere astronomers look in apparent defiance of established theory. The author addresses this problem, analyzing the different possible explanations for such an anomaly, which include interaction with a binary companion, the production of Li in the interior of the star with its subsequent transport to stellar exteriors, and the stellar interaction with planets. The author focuses on this last possibility, where the Li enrichment may be due to the ingestion of planets or brown dwarfs as the stars in question grew in size while becoming giants. She shows that this process is indeed able to explain an important fraction of giants with Li levels above the three times solar threshold, but that some other mechanism is needed to explain the remaining fraction. While this is an important discovery in its own right, the result that makes this thesis groundbreaking is its demonstration that the threshold between Li-normal and Li-rich is mass dependent rather than a fixed proportion of the Sun's content. This corrects a fundamental misapprehension of the phenomenon and opens up a new framework in which to understand and solve the problem. Finally, the author presents interesting observational applications and samples with which to test this new approach to the problem of Li enrichment in giants.

This thesis describes the design, development, characterisation and clinical translation of three novel devices for optical endoscopic imaging. Over the past decade, rapid innovation in optics and photonics has led to the availability of low-cost and high-performance optical technologies that can be exploited for biomedical applications, but relatively few have been translated into clinic. The work presented outlines for the first time, a comprehensive analysis of the common barriers and unique challenges associated with the translation of optical imaging techniques. To assist developers streamline translation of optical imaging devices in future, a roadmap to clinical translation is outlined, and key translational characteristics are defined. Guided by these, subsequent development of endoscopic devices resulted in preparation and approval of endoscopes for first in human trials in the oesophagus, for early detection of cancer, and in the brain, for delineation of tumour during surgical resection. The thesis culminates in the presentation of results from the first in human use of a compact multispectral endoscope for imaging endogenous tissue contrast in the oesophagus. With continuation of the work as outlined at the end of this thesis, the novel techniques described have the potential to improve the standard of care in their respective indications.

This book recounts the developments of fundamental electrodynamics from Ampère's investigation of the forces between electric currents to Einstein's introduction of a new doctrine of space and time. Thorough accounts are given of crucial episodes such as Faraday's redefinition of charge and current, the genesis of Maxwell's field equations, and Hertz' experiments on fast electric oscillations. Darrigol provides a vivid picture of the intellectual and instrumental variety of nineteenth century physics, emphasising the diverse, evolving practices of electrodynamics, and the interactions between the corresponding scientific traditions. This richly documented, clearly written, and abundantly illustrated history should appeal to students and scholars of physics, and also to those interested in the history and philosophy of science.

This book provides a unified treatment of the characteristics of telescopes of all types, both those whose performance is set by geometrical aberrations and the effect of the atmosphere, and those diffraction-limited telescopes designed for observations from above the atmosphere. The emphasis throughout is on basic principles, such as Fermat's principle, and their application to optical systems specifically designed to image distant celestial sources.
The book also contains thorough discussions of the principles underlying all spectroscopic instrumentation, with special emphasis on grating instruments used with telescopes. An introduction to adaptive optics provides the needed background for further inquiry into this rapidly developing area.

* Geometrical aberration theory based on Fermat's principle
* Diffraction theory and transfer function approach to near-perfect telescopes
* Thorough discussion of 2-mirror telescopes, including misalignments
* Basic principles of spectrometry; grating and echelle instruments
* Schmidt and other catadioptric telescopes
* Principles of adaptive optics
* Over 220 figures and nearly 90 summary tables

The invention of the semiconductor laser along with silica glass fiber has enabled an incredible revolution in global communication infrastructure of direct benefit to all. Development of devices and system concepts that exploit the same fundamental light-matter interaction continues. Researchers and technologists are pursuing a broad range of emerging applications, everything from automobile collision avoidance to secure quantum key distribution. This book sets out to summarize key aspects of semiconductor laser device physics and principles of laser operation. It provides a convenient reference and essential knowledge to be understood before exploring more sophisticated device concepts. The contents serve as a foundation for scientists and engineers, without the need to invest in specialized detailed study. Supplementary material in the form of MATLAB is available for numerically generated figures.

This monograph presents recent advances in neural network (NN) approaches and applications to chemical reaction dynamics. Topics covered include: (i) the development of ab initio potential-energy surfaces (PES) for complex multichannel systems using modified novelty sampling and feedforward NNs; (ii) methods for sampling the configuration space of critical importance, such as trajectory and novelty sampling methods and gradient fitting methods; (iii) parametrization of interatomic potential functions using a genetic algorithm accelerated with a NN; (iv) parametrization of analytic interatomic potential functions using NNs; (v) self-starting methods for obtaining analytic PES from ab inito electronic structure calculations using direct dynamics; (vi) development of a novel method, namely, combined function derivative approximation (CFDA) for simultaneous fitting of a PES and its corresponding force fields using feedforward neural networks; (vii) development of generalized PES using many-body expansions, NNs, and moiety energy approximations; (viii) NN methods for data analysis, reaction probabilities, and statistical error reduction in chemical reaction dynamics; (ix) accurate prediction of higher-level electronic structure energies (e.g. MP4 or higher) for large databases using NNs, lower-level (Hartree-Fock) energies, and small subsets of the higher-energy database; and finally (x) illustrative examples of NN applications to chemical reaction dynamics of increasing complexity starting from simple near equilibrium structures (vibrational state studies) to more complex non-adiabatic reactions.
The monograph is prepared by an interdisciplinary group of researchers working as a team for nearly two decades at Oklahoma State University, Stillwater, OK with expertise in gas phase reaction dynamics; neural networks; various aspects of MD and Monte Carlo (MC) simulations of nanometric cutting, tribology, and material properties at nanoscale; scaling laws from atomistic to continuum; and neural networks applications to chemical reaction dynamics. It is anticipated that this emerging field of NN in chemical reaction dynamics will play an increasingly important role in MD, MC, and quantum mechanical studies in the years to come.

Marine enzymes and specialized metabolism - Part B, Volume 605 in the Methods in Enzymology series, highlights experimental methods on diverse marine enzymes involved in the construction of bioactive natural product molecules. Unique sections in this new release include discussions on polysaccharide-degrading enzymes from marine gastropods, radical SAM epimerases from sponge microbes, DMS/P demethylase in bacteria, reconstitution of particulate methane monooxygenase into membrane mimetics, the structure and function of cyanobactin enzymes, marine cyanobacterial polyketide beta-branching enzymology, marine cyanobacterial PKS-NRPS enzymology and structural biology, biochemical profiling of DMSP lyases, and more.

Black holes entered the world of science fiction and films in the 1960s, and their popularity in our culture remains today. The buzz surrounding black holes was and is due, in large part, to their speculative nature. It is still difficult for the general public to determine fact versus fiction as it pertains to this terrifying idea: something big enough to swallow anything and everything in close proximity, with a gravitational force so strong that nothing, including light, can escape. In the fall of 2015, scientists at the Laser Interferometry Gravitational-Wave Observatory (LIGO) detected the first sounds from black holes, brought to earth by the gravitational waves that emitted from the merging of two black holes 1.4 billion light years away in space. This confirmed the existence of gravitational waves, which Albert Einstein predicted in 1916. In the spring of 2017, physicists and astronomers who were working on the Event Horizon Telescope (EHT) project captured the first image of a black hole. This was the supermassive black hole hosted by the galaxy M87 in the constellation Virgo, 53 million light years away, and the image shows the shadow the black hole casts upon the bright light surrounding it. In this book, John Moffat shares the history of black holes and presents the latest research into these mysterious celestial objects, including the astounding results from gravitational wave detection and the shadow of the black hole.

This book provides a general introduction to nanogels, and designs of various stimuli-sensitive nanogels that are able to control drug release in response to specific stimuli. Nanogels are three-dimensional nanosized networks that formed by physically or chemically crosslinking polymers. They have highly interesting properties such as biocompatibility, high stability, particle size adjustment, drug loading capability and modification of the surface for active targeting. They can respond to stimuli which results in the controlled release of drug and targeting of the site.

This book presents the fundamentals and the state of the art of the photophysics of molecular oxygen. The author examines optical transitions between the lowest-lying electronic states in molecular oxygen and how these transitions respond to perturbation, either from an organic molecule or from the plasmon field of a metal nanoparticle. We live on a planet filled with light and oxygen. The interaction between these two components forms the basis of excited state chemistry spanning the fields of synthetic organic chemistry, materials chemistry, molecular biology, and photodynamic treatment of cancer. Still, the fundamental ways in which oxygen is affected by light is an active subject of research and is continually being developed and rationalized. In this book, readers will learn that singlet oxygen, the excited state of oxygen that exhibits unique chemical reactivity, can be selectively made via direct optical excitation of oxygen in a sensitizer-free system. Readers will also discover that this approach can perturb living cells differently depending on the singlet oxygen "dose".

Biophysical Basis of Physiology and Calcium Signaling Mechanism in Cardiac and Smooth Muscle acts as a bridge between physiology and physics by discussing the physiology and calcium signaling mechanism in cardiac and smooth muscle. By exploring the mechanism of the cyclic release of stored Ca^(2+) in the SR or ER, this book covers the cell communication system, including excitable cells, recognizing the most relevant mechanisms of cell communication. Serving as a bridge between physiology and physics, coverage spans the physiology and calcium signaling mechanism in cardiac and smooth muscle, offering insight to physiological scientists, pharmaceutical scientists, medical doctors, biologists and physicists.

At the heart of this book is the generalized theoretical approach that is applied to investigate the geoelectrical structure of the Earth's mantle. It also analyzes the results of regional and global induction sounding of the Earth's mantle and compares them with the results obtained by other geophysical methods. The generalized theoretical approach employs the Induction Law as a basis for identifying extended relations between magnetic field components, including their plane divergence, impedances and spatial derivatives. The estimations of impedance values and spatial derivatives are performed using the theory of stochastic processes. The book also considers the external sources of magnetic fields used for sounding the Earths mantle from the modern theory perspective, as well as the problem of coincidence of magneto-variation and magnetotelluric methods. Further, it discusses secular variations in the Earth's resistance caused by non-induction sources, factors that are correlated with the number of earthquakes in the region and shifted in time with global indexes. It is a valuable resource for scientists applying deep induction soundings or interested in the structures of and processes in the Earth's interior.

This book focuses on the microscopic understanding of the function of organic semiconductors. By tracing the link between their morphological structure and electronic properties across multiple scales, it represents an important advance in this direction. Organic semiconductors are materials at the interface between hard and soft matter: they combine structural variability, processibility and mechanical flexibility with the ability to efficiently transport charge and energy. This unique set of properties makes them a promising class of materials for electronic devices, including organic solar cells and light-emitting diodes. Understanding their function at the microscopic scale - the goal of this work - is a prerequisite for the rational design and optimization of the underlying materials. Based on new multiscale simulation protocols, the book studies the complex interplay between molecular architecture, supramolecular organization and electronic structure in order to reveal why some materials perform well - and why others do not. In particular, by examining the long-range effects that interrelate microscopic states and mesoscopic structure in these materials, the book provides qualitative and quantitative insights into e.g. the charge-generation process, which also serve as a basis for new optimization strategies.

This thesis focuses on theoretical analysis of the sophisticated ultrafast optical experiments that probe the crucial first few picoseconds of quantum light harvesting, making an important contribution to quantum biology, an exciting new field at the intersection of condensed matter, physical chemistry and biology. It provides new insights into the role of vibrational dynamics during singlet fission of organic pentacene thin films, and targeting the importance of vibrational dynamics in the design of nanoscale organic light harvesting devices, it also develops a new wavelet analysis technique to probe vibronic dynamics in time-resolved nonlinear optical experiments. Lastly, the thesis explores the theory of how non-linear "breather" vibrations are excited and propagate in the disordered nanostructures of photosynthetic proteins.