This book provides a concise introduction to the special theory of relativity and the general theory of relativity. The format has been chosen to provide the basis for a single semester course that can take the students all the way from the foundations of special relativity to the core results of general relativity: the Einstein equation, and the equations of motion for particles and light in curved spacetime. To facilitate access to the topics of special and general relativity for science and engineering students, without prior training in relativity or geometry, the relevant geometric notions are also introduced.

This thesis describes the design, development, characterisation and clinical translation of three novel devices for optical endoscopic imaging. Over the past decade, rapid innovation in optics and photonics has led to the availability of low-cost and high-performance optical technologies that can be exploited for biomedical applications, but relatively few have been translated into clinic. The work presented outlines for the first time, a comprehensive analysis of the common barriers and unique challenges associated with the translation of optical imaging techniques. To assist developers streamline translation of optical imaging devices in future, a roadmap to clinical translation is outlined, and key translational characteristics are defined. Guided by these, subsequent development of endoscopic devices resulted in preparation and approval of endoscopes for first in human trials in the oesophagus, for early detection of cancer, and in the brain, for delineation of tumour during surgical resection. The thesis culminates in the presentation of results from the first in human use of a compact multispectral endoscope for imaging endogenous tissue contrast in the oesophagus. With continuation of the work as outlined at the end of this thesis, the novel techniques described have the potential to improve the standard of care in their respective indications.

Comprehensive and up-to-date information on Earth's most dominant year-to-year climate variation The El Nino Southern Oscillation (ENSO) in the Pacific Ocean has major worldwide social and economic consequences through its global scale effects on atmospheric and oceanic circulation, marine and terrestrial ecosystems, and other natural systems. Ongoing climate change is projected to significantly alter ENSO's dynamics and impacts. El Nino Southern Oscillation in a Changing Climate presents the latest theories, models, and observations, and explores the challenges of forecasting ENSO as the climate continues to change. Volume highlights include: Historical background on ENSO and its societal consequences Review of key El Nino (ENSO warm phase) and La Nina (ENSO cold phase) characteristics Mathematical description of the underlying physical processes that generate ENSO variations Conceptual framework for understanding ENSO changes on decadal and longer time scales, including the response to greenhouse gas forcing ENSO impacts on extreme ocean, weather, and climate events, including tropical cyclones, and how ENSO affects fisheries and the global carbon cycle Advances in modeling, paleo-reconstructions, and operational climate forecasting Future projections of ENSO and its impacts Factors influencing ENSO events, such as inter-basin climate interactions and volcanic eruptions The American Geophysical Union promotes discovery in Earth and space science for the benefit of humanity. Its publications disseminate scientific knowledge and provide resources for researchers, students, and professionals. Find out more about this book from this Q&A with the editors.

This book presents an overview of antimicrobial peptides (AMPs), their mechanisms of antimicrobial action, other activities, and various problems that must still be overcome regarding their clinical application. Divided into four major parts, the book begins with a general overview of AMPs (Part I), and subsequently discusses the various mechanisms of antimicrobial action and methods for researching them (Part 2). It then addresses a range of activities other than antimicrobial action, such as cell penetration, antisepsis, anticancer, and immunomodulatory activities (Part 3), and explores the prospects of clinical application from various standpoints such as the selective toxicity, design, and discovery of AMPs (Part 4). A huge number of AMPs have been discovered in plants, insects, and vertebrates including humans, and constitute host defense systems against invading pathogenic microorganisms. Consequently, many attempts have been made to utilize AMPs as antibiotics. AMPs could help to solve the urgent problem of drug-resistant bacteria, and are also promising with regard to sepsis and cancer therapy. Gathering a wealth of information, this book will be a bible for all those seeking to develop antibiotics, anti-sepsis, or anticancer agents based on AMPs.

This book discusses in detail the special theory of relativity without including all the instruments of theoretical physics, enabling readers who are not budding theoretical physicists to develop competence in the field. An arbitrary but fixed inertial system is chosen, where the known velocity of light is measured. With respect to this system a moving clock loses time and a moving length contracts. The book then presents a definition of simultaneity for the other inertial frames without using the velocity of light. To do so it employs the known reciprocity principle, which in this context serves to provide a definition of simultaneity in the other inertial frames. As a consequence, the Lorentz transformation is deduced and the universal constancy of light is established. With the help of a lattice model of the special theory of relativity the book provides a deeper understanding of the relativistic effects. Further, it discusses the key STR experiments and formulates and solves 54 problems in detail.

Cold atmospheric plasma (CAP) emerges as a possible new modality for cancer treatment. This book provides a comprehensive introduction into the fundamentals of the CAP and plasma devices used in plasma medicine. An analysis of the mechanisms of plasma interaction with cancer and normal cells, including a description of possible mechanisms of plasma selectivity, is included. Recent advances in the field, the primary challenges and future directions are also presented.

Integrated Nano-Biomechanics provides an integrated look into the rapidly evolving field of nanobiomechanics. The book demystifies the processes in living organisms at the micro- and nano-scale through mechanics, using theoretical, computational and experimental means. The book develops the concept of integrating different technologies along the hierarchical structure of biological systems and clarifies biomechanical interactions among different levels for the analysis of multi-scale pathophysiological phenomena. With a focus on nano-scale processes and biomedical applications, it is shown how knowledge obtained can be utilized in a range of areas, including diagnosis and treatment of various human diseases and alternative energy production. This book is based on collaboration of researchers from a unique combination of fields, including biomechanics, computational mechanics, GPU application, electron microscopy, biology of motile micro-organisms, entomological mechanics and clinical medicine. The book will be of great interest to scientists and researchers involved in disciplines, such as micro- and nano-engineering, bionanotechnology, biomedical engineering, micro- and nano-scale fluid-mechanics (such as in MEMS devices), nanomedicine and microbiology, as well as industries such as optical devices, computer simulation, plant based energy sources and clinical diagnosis of the gastric diseases.

Following the breakthrough in the last decade in identifying the key parameters for time and depth imaging in anisotropic media and developing practical methodologies for estimating them from seismic data, this title primarily focuses on the far reaching exploration benefits of anisotropic processing.

This volume provides the first comprehensive description of reflection seismic signatures and processing methods in anisotropic media. It identifies the key parameters for time and depth imaging in transversely isotropic media and describes practical methodologies for estimating them from seismic data. Also, it contains a thorough discussion of the important issues of uniqueness and stability of seismic velocity analysis in the presence of anisotropy. The book contains a complete description of anisotropic imaging methods, from the theoretical background to algorithms to implementation issues. Numerous applications to synthetic and field data illustrate the improvements achieved by the anisotropic processing and the possibility of using the estimated anisotropic parameters in lithology discrimination.

All living matter is comprised of cells; small compartments isolated from the environment by a cell membrane and filled with concentrated solutions of various organic and inorganic compounds. Some organisms are a single cell and all life functions are performed by that cell. Others have groups of cells, or entire organs, specializing in one particular function. The survival of the entire organism depends on all its cells and organs fulfilling their roles. The aim of this book is to investigate the basic physical phenomena occurring in cells. These physical transport processes facilitate chemical reactions in the cell and that, in turn, leads to the biological functions necessary for the cell to satisfy its role in the mother organism. Ultimately, the goal of every cell is to stay alive and to fulfil its function as a part of a larger organ or organism. This first volume is an inventory of physical transport processes occurring in cells, while the second volume will take a closer look at how complex biological and physiological cell phenomena result from these very basic physical processes.

This book presents the fundamentals and the state of the art of the photophysics of molecular oxygen. The author examines optical transitions between the lowest-lying electronic states in molecular oxygen and how these transitions respond to perturbation, either from an organic molecule or from the plasmon field of a metal nanoparticle. We live on a planet filled with light and oxygen. The interaction between these two components forms the basis of excited state chemistry spanning the fields of synthetic organic chemistry, materials chemistry, molecular biology, and photodynamic treatment of cancer. Still, the fundamental ways in which oxygen is affected by light is an active subject of research and is continually being developed and rationalized. In this book, readers will learn that singlet oxygen, the excited state of oxygen that exhibits unique chemical reactivity, can be selectively made via direct optical excitation of oxygen in a sensitizer-free system. Readers will also discover that this approach can perturb living cells differently depending on the singlet oxygen "dose".

Complexity of Seismic Time Series: Measurement and Application applies the tools of nonlinear dynamics to seismic analysis, allowing for the revelation of new details in micro-seismicity, new perspectives in seismic noise, and new tools for prediction of seismic events. The book summarizes both advances and applications in the field, thus meeting the needs of both fundamental and practical seismology. Merging the needs of the classical field and the very modern terms of complexity science, this book covers theory and its application to advanced nonlinear time series tools to investigate Earth's vibrations, making it a valuable tool for seismologists, hazard managers and engineers.

Indian Shield: Precambrian Evolution and Phanerozoic Reconstitution highlights unique evolutionary trends covering a period of over 3,500 million years, from the oldest crust to the most recent geological activity of the Indian Subcontinent. The book discusses regional terrain geology in terms of the evolutionary history of the crust, describing how the Precambrian Shield evolved from a stable continental region to a tectonically unstable zone marked by frequent high-intensity earthquakes in a Plate-interior setting. It is a complete and readable account of the history of growth and evolution of the Indian Subcontinent, including Bangladesh, Bhutan, India, Nepal and Pakistan. The book is intended for graduate students, researchers, and teachers in the geosciences, especially geophysics, geomorphology and geology. The book also serves as an important resource for tectonics and petrology researchers, as well as those involved in exploration of mineral resources.

For almost three quarters of a century, the United States has spent billions of dollars and countless person-hours in the pursuit of a national missile defense system that would protect the country from intercontinental ballistic missiles (ICBM) carrying nuclear warheads. The system currently in place consists of 44 long-range antiballistic missiles stationed in Alaska and California to protect the United States from a possible nuclear weapon carrying ICBM attack from North Korea. After all this effort, this systemis still imperfect, being successful only 10 out of 18 tests. This book will provide an historical description of past efforts in national missile defenses to understand the technical difficulties involved. It will also explain how national security concerns, the evolving international environment, and the complexities of US politics have all affected the story. The book will also describe the current systems in place to protect allies and troops in the field from the threat of shorter range missiles. Finally, the book will describe the current US vision for the future of missile defenses and provide some suggestions for alternative paths.

Prior to the 1920s it was generally thought, with a few exceptions, that our galaxy, the Milky Way, was the entire universe. Based on the work of Henrietta Leavitt with Cepheid variables, astronomer Edwin Hubble was able to determine that others had to lie outside our own. This books looks at 60 of those that possess some unusual qualities that make them of particular interest, from supermassive black holes and colliding galaxies to powerful radio sources.

This book describes in detail the various theories on the shape of the Earth from classical antiquity to the present day and examines how measurements of its form and dimensions have evolved throughout this period. The origins of the notion of the sphericity of the Earth are explained, dating back to Eratosthenes and beyond, and detailed attention is paid to the struggle to establish key discoveries as part of the cultural heritage of humanity. In this context, the roles played by the Catholic Church and the philosophers of the Middle Ages are scrutinized. Later contributions by such luminaries as Richer, Newton, Clairaut, Maupertuis, and Delambre are thoroughly reviewed, with exploration of the importance of mathematics in their geodetic enterprises. The culmination of progress in scientific research is the recognition that the reference figure is not a sphere but rather a geoid and that the earth's shape is oblate. Today, satellite geodesy permits the solution of geodetic problems by means of precise measurements. Narrating this fascinating story from the very beginning not only casts light on our emerging understanding of the figure of the Earth but also offers profound insights into the broader evolution of human thought.

In the field of particle and astrophysics one of the major unresolved problems is to understand the nature and properties of dark matter, which constitutes almost 80% of the matter content of the universe. This book gives a pedagogical introduction to the field of dark matter in general, and in particular to the model building perspective. This book focuses on teaching the basic tools for model building of dark matter, and it aims to motivate the reader to propose a new dark matter model.

This book describes the life, times and science of the Soviet physicist Lev Vasilevich Shubnikov (1901-1937). From 1926 to 1930 Shubnikov worked in Leiden where he was the co-discoverer of the Shubnikov-De Haas effect. After his return to the Soviet Union he founded in Kharkov in Ukraine the first low-temperature laboratory in the Soviet Union, which in a very short time became the foremost physics institute in the country and among other things led to the discovery of type-II superconductivity. In August 1937 Shubnikov, together with many of his colleagues, was arrested and shot early in November 1937. This gripping story gives deep insights into the pioneering work of Soviet physicists before the Second World War, as well as providing much previously unpublished information about their brutal treatment at the hands of the Stalinist regime.

Marine enzymes and specialized metabolism - Part B, Volume 605 in the Methods in Enzymology series, highlights experimental methods on diverse marine enzymes involved in the construction of bioactive natural product molecules. Unique sections in this new release include discussions on polysaccharide-degrading enzymes from marine gastropods, radical SAM epimerases from sponge microbes, DMS/P demethylase in bacteria, reconstitution of particulate methane monooxygenase into membrane mimetics, the structure and function of cyanobactin enzymes, marine cyanobacterial polyketide beta-branching enzymology, marine cyanobacterial PKS-NRPS enzymology and structural biology, biochemical profiling of DMSP lyases, and more.

This thesis focuses on theoretical analysis of the sophisticated ultrafast optical experiments that probe the crucial first few picoseconds of quantum light harvesting, making an important contribution to quantum biology, an exciting new field at the intersection of condensed matter, physical chemistry and biology. It provides new insights into the role of vibrational dynamics during singlet fission of organic pentacene thin films, and targeting the importance of vibrational dynamics in the design of nanoscale organic light harvesting devices, it also develops a new wavelet analysis technique to probe vibronic dynamics in time-resolved nonlinear optical experiments. Lastly, the thesis explores the theory of how non-linear "breather" vibrations are excited and propagate in the disordered nanostructures of photosynthetic proteins.

This book recounts the developments of fundamental electrodynamics from Ampère's investigation of the forces between electric currents to Einstein's introduction of a new doctrine of space and time. Thorough accounts are given of crucial episodes such as Faraday's redefinition of charge and current, the genesis of Maxwell's field equations, and Hertz' experiments on fast electric oscillations. Darrigol provides a vivid picture of the intellectual and instrumental variety of nineteenth century physics, emphasising the diverse, evolving practices of electrodynamics, and the interactions between the corresponding scientific traditions. This richly documented, clearly written, and abundantly illustrated history should appeal to students and scholars of physics, and also to those interested in the history and philosophy of science.