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Books > Science & Mathematics > Biology, life sciences > Biochemistry

Stearoyl-CoA Desaturase Genes in Lipid Metabolism (Hardcover, 2013 ed.): James M. Ntambi, Ph.D. Stearoyl-CoA Desaturase Genes in Lipid Metabolism (Hardcover, 2013 ed.)
James M. Ntambi, Ph.D.
R4,913 R4,640 Discovery Miles 46 400 Save R273 (6%) Ships in 10 - 15 working days

Obesity and diabetes develop as a complex result of genetic, metabolic and environmental factors and are characterized by increased lipogenesis and lipid accumulation in many tissues. Stearoyl-CoA desaturase (SCD) genes are a critical regulator of lipogenesis and catalyzes the synthesis of monounsaturated fatty acids (MUFA), mainly oleoyl- (18:1n9) and palmitoleoyl-CoA (16:1n7). These MUFAs are the major fatty acid substrates for the synthesis of triglycerides, cholesterol esters, wax esters and membrane phospholipids. There are 4 SCD isoforms (SCD1-4) in mice and two (hSCD1 and hSCD5) expressed in humans. At first glance, stearoyl-CoA desaturase enzyme would be considered a housekeeping enzyme because it synthesizes oleate a well-known fatty acid that is abundant in many dietary sources. However numerous studies have shown that SCD is a very highly regulated enzyme that features in so many physiological processes ranging from fat differentiation, carbohydrate and fat metabolism, inflammation and cancer. The editor's studies using stearoyl-CoA desaturase knockout (SCD1-/-) mice and studies of other investigators using pharmacological approaches to reduce SCD1 expression in mouse tissues have all established that the expression of SCD1 gene isoform represents a key step in partitioning of lipids between storage and oxidation. High SCD expression favors fat storage leading to obesity while reduced SCD expression favors fat burning and leanness. Although these studies clearly illustrated that SCD1 expression is involved in the development of obesity and insulin resistance, questions remain in the elucidation of the mechanisms involved and role of SCD1. This book includes chapters by leading researchers on SCD Genes in the brain, heart, muscle, liver metabolism, Colitis, and more.

Purification and Characterization of Secondary Metabolites - A Laboratory Manual for Analytical and Structural Biochemistry... Purification and Characterization of Secondary Metabolites - A Laboratory Manual for Analytical and Structural Biochemistry (Paperback)
Thomas E. Crowley
R2,476 Discovery Miles 24 760 Ships in 10 - 15 working days

Purification and Characterization of Secondary Metabolites: A Laboratory Manual for Analytical and Structural Biochemistry provides students with working knowledge of the fundamental and advanced techniques of experimental biochemistry. Sections provide an overview of the microbiological and biochemical methods typically used for the purification of metabolites and discuss the biological significance of secondary metabolites secreted by three diverse species of bacteria. Additionally, this lab manual covers the theory and practice of the most commonly-used techniques of analytical biochemistry, UV-vis and IR spectrophotometry, high-performance liquid chromatography, mass spectrometry, X-ray crystallography and nuclear magnetic resonance, and how to evaluate and effectively use scientific data. Instructors will find this book useful because of the modular nature of the lab exercises included. Written in a logical, easy-to-understand manner, this book is an indispensable resource for both students and instructors.

Insect Pheromone Biochemistry and Molecular Biology - The Biosynthesis and Detection of Pheromones and Plant Volatiles... Insect Pheromone Biochemistry and Molecular Biology - The Biosynthesis and Detection of Pheromones and Plant Volatiles (Hardcover, New)
Gary Blomquist
R2,762 Discovery Miles 27 620 Ships in 10 - 15 working days

A valuable new reference on insect behavior, this exceptional new text delves into the primary sensory communication system used by most insects -- their sense of smell. This important text covers how insects produce pheromones and how they detect pheromones and plant volatiles. Since insects rely on pheromone detection for both feeding and breeding, a better understanding of insect olfaction and pheromone biosynthesis could help curb the behavior of pests without the use of harmful pesticides and even help to reduce the socio-economic impacts associated to human-insect interactions.
* Covers biochemistry and molecular biology of insect pheromone production
* Explains pheromone production in moths, beetles, flies, and social insects
* Describes pheromone and plant volatile reception

Clinical Studies in Medical Biochemistry (Hardcover, 3rd Revised edition): Robert H. Glew, Miriam Rosenthal Clinical Studies in Medical Biochemistry (Hardcover, 3rd Revised edition)
Robert H. Glew, Miriam Rosenthal
R3,626 Discovery Miles 36 260 Ships in 10 - 15 working days

This text uses a case-study approach to present the core principles of biochemistry and molecular biology in the context of human disease to students who will be involved in patient care. The 33 cases are carefully selected to cover key concepts and common diseases. Each chapter provides a specific patient report that includes the relevant history, pertinent clinical laboratory data, physical findings, and subsequent diagnosis. This is followed by a comprehensive discussion of the normal biochemical processes and reactions pertaining to the case, along with the pathophysiological mechanisms of the disease. In this third edition of the book, a new co-editor has aided in the substantially revised and more targeted selection of cases. The whole volume is now clearly focussed on intermediary metabolism and other topics central to biochemistry. There are new chapters on topics such as collagen structure, mitochondrial metabolism, and hyperhomocysteinemia and vascular disease. There is also more coverage of nutrional biochemistry, including new chapters on protein-calorie malnutrition, obesity, vitamin A deficiency, and iron metabolism.The best cases were retained from the previous edition, and have been completely rewritten and updated to include recent advances in diagnostic biochemistry and the status of current therapies. Although the first edition was intended primarily for medical students, through the years the book has proven useful for a wide variety of students interested in the health science professions.

Advances in Macromolecular Carbohydrate Research, Volume 2 (Hardcover): Robert J. Sturgeon Advances in Macromolecular Carbohydrate Research, Volume 2 (Hardcover)
Robert J. Sturgeon
R6,468 Discovery Miles 64 680 Ships in 10 - 15 working days

In recent years the most significant advances in carbohydrate research have been made in the knowledge of the structure and function of carbohydrates in the macromolecular state. This title addresses those areas in which the authors believe the most important work is being carried out.
Successfully deals with significant advances in the understanding of the chemistry, biochemistry and biology of carbohydrates.
Comprehensive reviews provided throughout by the authors, in this ever popular field.

Intrinsically Disordered Proteins - Dynamics, Binding, and Function (Paperback): Nicola Salvi Intrinsically Disordered Proteins - Dynamics, Binding, and Function (Paperback)
Nicola Salvi
R3,037 Discovery Miles 30 370 Ships in 10 - 15 working days

Intrinsically Disordered Proteins: Dynamics, Binding, and Function thoroughly examines and ties together the fundamental biochemical functions of intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs), including signaling, binding, and regulation, with the methodology for study and the associated pathways for drug design and therapeutic intervention. The role of new mechanistic, computational, and experimental approaches in IDP study are explored in depth, with methods for the characterization of IDP dynamics; models, simulations, and mechanisms of IDP and IDR binding; and biological and medical implications of IDP dynamics prominently featured. Written and edited by leading scientists in the field, this book explores groundbreaking areas such as ensemble descriptions of IDPs and IDRs, single-molecule studies of IDPs and IDRs, IDPs and IDRs in membraneless organelles, and molecular mechanisms of fibrillation of IDPs. Intrinsically Disordered Proteins provides students and researchers in biochemistry, molecular biology, and applied microbiology with a comprehensive and updated discussion of the complex dynamics of IDPs and IDRs.

Vitamin E in Health and Disease (Hardcover): Jose Antonio Morales-Gonzalez Vitamin E in Health and Disease (Hardcover)
Jose Antonio Morales-Gonzalez
R3,052 Discovery Miles 30 520 Ships in 18 - 22 working days
Peroxidases and Catalases - Biochemistry, Biophysics, Biotechnology and Physiology (Hardcover, 2 Rev Ed): H.Brian Dunford Peroxidases and Catalases - Biochemistry, Biophysics, Biotechnology and Physiology (Hardcover, 2 Rev Ed)
H.Brian Dunford
R5,535 Discovery Miles 55 350 Ships in 18 - 22 working days

SINGLE SOURCE GUIDE TO PEROXIDASES AND CATALASES

Reflecting the important historical discoveries and exciting research in the field in recent years, "Peroxidases and Catalases: Biochemistry, Biophysics, Biotechnology and Physiology" provides a much-needed systematic, up-to-date treatment of peroxidases and catalases.

From the structure and properties of the various superfamilies to current applications of peroxidases, the book consolidates vast amounts of information previously scattered in the professional literature, covering all aspects of these ubiquitous enzymes that act on a variety of substances and processes in living systems--their properties, reactions, crystal structures, cloning, and more.

Considering the subject from both theoretical and applied perspectives, "Peroxidases and Catalases" offers a critical review of the literature and detailed discussions of the most current research. Chapters cover:

The background and history of peroxidases and catalases

Plant, fungal, and bacterial peroxidase superfamilies and their organization

Mammalian peroxidases including medical and physiological roles

Spectroscopic and theoretical techniques for studying peroxidases highlighting the contributions of physicists and physical/theoretical chemists

Heme peroxidases, catalases, and other peroxidases such as vanadium and selenium peroxidase

Relevant plant and animal physiology

This one-stop reference is a vital reference for biochemists, biologists, biochemical engineers, physiologists, environmental and pharmaceutical researchers, and others interested in the study and use of peroxidases and catalases.

Studies in Natural Products Chemistry, Volume 28 - Bioactive Natural Products (Part I) (Hardcover): Atta-ur Rahman Studies in Natural Products Chemistry, Volume 28 - Bioactive Natural Products (Part I) (Hardcover)
Atta-ur Rahman
R12,485 Discovery Miles 124 850 Ships in 10 - 15 working days

The book contains articles written by leading authorities in their respective fields of research. It presents current frontiers and future guidelines for research based on important discoveries made in the field of bioactive natural products.
- Volume 28 is part of a great family of useful reference books
- Illustrates the types of critical discoveries that emerge from the interface of chemistry and biology
- Contributions are from well-respected authors

Lactic Acid Bacteria - Bioengineering and Industrial Applications (Hardcover, 1st ed. 2019): Wei Chen Lactic Acid Bacteria - Bioengineering and Industrial Applications (Hardcover, 1st ed. 2019)
Wei Chen
R4,716 Discovery Miles 47 160 Ships in 18 - 22 working days

This book introduces readers to basic studies on and applied techniques involving lactic acid bacteria, including their bioengineering and industrial applications. It summarizes recent biotechnological advances in lactic acid bacteria for food and health, and provides detailed information on the applications of these bacteria in fermented foods. Accordingly, it offers a valuable resource for researchers and graduate students in the fields of food microbiology, bioengineering, fermentation engineering, food science, nutrition and health.

Selected Topics in the History of Biochemistry, Volume 42 - Personal Recollections VII (Hardcover): G. Semenza, A.J. Turner Selected Topics in the History of Biochemistry, Volume 42 - Personal Recollections VII (Hardcover)
G. Semenza, A.J. Turner
R4,604 Discovery Miles 46 040 Ships in 10 - 15 working days

This book is the latest volume in a highly successful series within "Comprehensive Biochemistry "and provides a historical and autobiographical perspective of the development of the field through the contributions of leading individuals who reflect on their careers and their impact on biochemistry. The book is essential reading for everybody, from graduate student to professor, placing in context major advances not only in biochemical terms but in relation to historical and social developments. Readers will be delighted by the lively style and the insight into the lives and careers of leading scientists of their time.

Collagen - Methods and Protocols (Hardcover, 1st ed. 2019): Irit Sagi, Nikolaos A. Afratis Collagen - Methods and Protocols (Hardcover, 1st ed. 2019)
Irit Sagi, Nikolaos A. Afratis
R4,742 Discovery Miles 47 420 Ships in 18 - 22 working days

This detailed volume compiles state-of-the-art protocols that will serve as recipes for scientists researching collagen, an abundant protein with great importance to health and disease, as well as in applications like food, cosmetics, pharmaceuticals, cosmetic surgery, artificial skin, and glue. Beginning with a section on in vitro models for the characterization of collagen formation, the book continues by highlighting large-scale analysis of collagen with mass spectrometry in order to elucidate the proteomics, degradomics, interactomes, and cross-linking of collagen, high resolution imaging approaches for collagen by the use of scanning electron microscopy and multiphoton imaging, as well as the role of collagen during physiological and pathological conditions. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Collagen: Methods and Protocols is an ideal guide to high quality and repeatable protocols in this vital field of study.

Vitamin A (Hardcover): Leila Queiroz Zepka, Veridiana Vera De Rosso, Eduardo Jacob-Lopes Vitamin A (Hardcover)
Leila Queiroz Zepka, Veridiana Vera De Rosso, Eduardo Jacob-Lopes
R3,054 Discovery Miles 30 540 Ships in 18 - 22 working days
Ecometabolomics - Metabolic Fluxes versus Environmental Stoichiometry (Paperback): Sumira Jan, Parvaiz Ahmad Ecometabolomics - Metabolic Fluxes versus Environmental Stoichiometry (Paperback)
Sumira Jan, Parvaiz Ahmad
R3,988 Discovery Miles 39 880 Ships in 10 - 15 working days

Ecometabolomics: Metabolic Fluxes versus Environmental Stoichiometry focuses on the interaction between plants-particularly plants that have vigorous secondary metabolites-and the environment. The book offers a comprehensive overview of the responses of the metabolome of organisms to biotic and abiotic environmental changes. It includes an introduction to metabolomics, summaries of metabolomic techniques and applications, studies of stress in plants, and insights into challenges. This is a must-have reference for plant biologists, plant biochemists, plant ecologists and phytochemists researching the interface between plants and the environment using metabolomics.

Marine Polysaccharides: An Applied Approach (Hardcover): Stephan Blackwood Marine Polysaccharides: An Applied Approach (Hardcover)
Stephan Blackwood
R3,264 R2,954 Discovery Miles 29 540 Save R310 (9%) Ships in 18 - 22 working days
Nitrogen Fixation at the Millennium (Hardcover): G.J. Leigh Nitrogen Fixation at the Millennium (Hardcover)
G.J. Leigh
R4,089 Discovery Miles 40 890 Ships in 10 - 15 working days

The turn of the millennium from the twentieth to the twenty-first century provides an occasion to review our understanding of a biological process, biological nitrogen fixation, that is of prime importance for the continued survival of mankind. This process has provided a basis for maintaining soil fertility since the beginning of organised agriculture, yet its very existence was confirmed only just over a century ago. In the intervening years, an enormous intellectual effort has dispersed much of the mystery surrounding biological nitrogen fixation. Biological fixation is widely exploited in agriculture, as are nitrogen fertilisers prepared for the last hundred years under extreme conditions of temperature and pressure. However, despite all our efforts, the fundamental nature of the reactions involved at the heart of the biological process remain unknown.


This book aims to describe what we have learned in the last one hundred years or so about biological nitrogen fixation, about what its chemistry appears to be, and how it is applied in agriculture. This ambitious objective has not been attempted recently. It is aimed at students and those who wish to enter these very challenging areas of research, and who need to learn the state of the art at the turn of the millennium.


The authors are all acknowledged world experts in their fields. They have prepared concise, well referenced and authoritative accounts of their subjects. This book provides a unique summary of the current state of knowledge that will be indispensable to all students and researchers, actual and potential, interested in biological nitrogen fixation.

Question Bank on Veterinary Biochemistry (Hardcover): Neera Jain Question Bank on Veterinary Biochemistry (Hardcover)
Neera Jain
R1,516 Discovery Miles 15 160 Ships in 18 - 22 working days
Mesoporous Silica-based Nanomaterials and Biomedical Applications - Part A, Volume 43 (Hardcover): Fuyuhiko Tamanoi Mesoporous Silica-based Nanomaterials and Biomedical Applications - Part A, Volume 43 (Hardcover)
Fuyuhiko Tamanoi
R3,446 Discovery Miles 34 460 Ships in 10 - 15 working days

Cancer Therapy and Diagnosis, Part A, Volume 43 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on Mesoporous silica nanoparticle synthesis, Periodic mesoporous organosilica, Nanovalves and other nanomachine-equipped nanoparticles and controlled release, Two-photon light control and photodynamic therapy, Biodegradable PMO nanoparticles, Cationic mesoporous silica and protein delivery, Drug loading, stimuli-responsive delivery and cancer treatment, Animal models and cancer therapy, siRNA delivery and TWIST shutdown for ovarian cancer treatment, and TBC (mesoporous silica nanoparticles and cancer therapy or biodistribution of MSN).

The Antiphospholipid Syndrome II - Autoimmune Thrombosis (Hardcover, 2nd ed.): R. Cervera, J.C. Piette, Y. Shoenfeld The Antiphospholipid Syndrome II - Autoimmune Thrombosis (Hardcover, 2nd ed.)
R. Cervera, J.C. Piette, Y. Shoenfeld
R4,958 R4,601 Discovery Miles 46 010 Save R357 (7%) Ships in 10 - 15 working days

This book provides the reader with a comprehensive overview of the Antiphospholipid syndrome. One of the most important advances in rheumatology and connective tissue diseases of the last decade. It provides an explanation for many previously undefined conditions with no clear pathogenesis encompassing all subspeculations in internal medicine as well as obstetrics. Clotting problems leading to strokes and myocardial infarctions (in younger people) as well as a large variety of other syndromes such as chorea, hyproadrenalism, pulmonary problems are now being understood.

Calpain - Methods and Protocols (Hardcover, 1st ed. 2019): Jeannette S. Messer Calpain - Methods and Protocols (Hardcover, 1st ed. 2019)
Jeannette S. Messer
R4,069 Discovery Miles 40 690 Ships in 18 - 22 working days

This volume brings together a plethora of protocols and experimental methods used by scientists to study calpains, their inhibitors, and their substrates. It also explores bioinformatic approaches to calpain substrate identification. The chapters in this book are divided into five parts and cover topics such as production and purification of calpains; determination of calpain localization, expression, and activity; identification of calpain-activated protein function; interrogation of calpastatin; and manipulation of calpain expression. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Calpain: Methods and Protocols is a valuable resource for researchers and scientists who want to learn more about this developing field, and get inspired to make new discoveries that will aid in diagnosing and treating calpain-related diseases.

Bioorganic Synthesis - An Introduction (Hardcover): Gary W. Morrow Bioorganic Synthesis - An Introduction (Hardcover)
Gary W. Morrow
R3,439 Discovery Miles 34 390 Ships in 10 - 15 working days

Over the last three decades, the interface between chemistry and biology has grown increasingly dynamic, resulting in the rapid expansion of communication and collaboration amongst research scientists, faculty and students in the fields of chemistry, biochemistry, biology, bioengineering, and beyond. This is due in part to society's growing demand for scientists, engineers and practitioners who can bring a more interdisciplinary approach to their work. For this reason, new elective courses at the undergraduate level that address topics crossing the traditional boundaries of chemistry and biology are increasingly necessary, as are courses that can provide traditional chemistry students with additional insight into the fundamental role that chemistry plays in the function and evolution of biological systems. Morrow's book builds on the foundation of a one-year introductory course in organic chemistry, focusing on familiar organic chemical processes associated with the biosynthesis of primary and secondary metabolites, with special emphasis on the latter group. Ultimately, it brings to undergraduate science majors the opportunity to develop a deeper understanding of fundamental mechanistic organic chemistry within a meaningful biological context that goes far beyond the usual boxed essays or supplemental problems that increasingly crowd the margins of many introductory organic chemistry textbooks. The book offers ideal support for courses in chemistry, biochemistry, biology, pre-medicine and bioengineering programs.

Enzymes in Synthetic Biology, Volume 608 (Hardcover): Nigel Scrutton Enzymes in Synthetic Biology, Volume 608 (Hardcover)
Nigel Scrutton
R4,324 Discovery Miles 43 240 Ships in 10 - 15 working days

Volume 608 of the series Methods in Enzymology covers key aspects of enzyme discovery, engineering tools and platforms, and examples of applications in the enzymology of synthetic biology.

Universes in Delicate Balance: Chemokines and the Nervous System (Hardcover, 1st ed): R.M. Ransohoff, K. Suzuki, A.E.I.... Universes in Delicate Balance: Chemokines and the Nervous System (Hardcover, 1st ed)
R.M. Ransohoff, K. Suzuki, A.E.I. Proudfoot, W.F. Hickey, J.K. Harrison
R4,466 Discovery Miles 44 660 Ships in 10 - 15 working days

It is commonly acknowledged that the nervous system and the immune system, those most complex of networks, share attributes beyond their intricacy. Elements common to the two systems include memory, connectivity, flexibility and developmental selection of cellular composition by a rigorous process involving widespread programmed cell death. There is one salient difference: the cells of the immune system are predominantly in constant motion, while post-mitotic neurons and glia are largely fixed in place. Therefore, chemokines, initially characterized as leukocyte chemoattractants, have for the last one and one-half decades been intensely and productively studied in the contexts of inflammation, immunity and hematopoietic development. Only recently have the two fields, neurobiology and immunology, displayed mutual interests in chemokines. This convergence of the two tribes of investigators was catalyzed by the finding that SDF-1 (now known as CXCL12) and its receptor, CXCR4, exerted significant and similar functions in development of both nervous and immune systems. Indeed CXCL12 and CXCR4 were required, in an uncannily similar fashion, for retention of pre-B lymphocytes at sites of maturation in the bone marrow and of neuronal progenitors in the external granule cell layer of the developing cerebellum. Recent reports indicate that chemoattraction of cerebellar granule cells through CXCR4 can be suppressed by reverse signaling initiated by binding of soluble eph receptors to transmembrane ephrin B, thereby establishing a link between chemokine action and a cardinal patterning system of the developing nervous system. As may be anticipated when a dam breaks, a massive influx of correlative observations in the nervous and immune systems is likely to ensue.


This volume represents the state of current knowledge. To this end, introductory material for both systems is provided. Basic and advanced 'chemokinology' are presented. The recipe for making a nervous system (both ingredients and instructions for preparation) is described, as are the roles of chemokines and their receptors in making an immune system. Given their importance and complexity, CXCL12/CXCR4 interactions are separately treated in varying contexts.


The field of 'neurobiology of chemokines' has not lain fallow during the last ten years. During much of this time the principal focus has been on neuroinflammation. Linking the immune and nervous systems are explanations of the functions of chemokines and their receptors for resident brain macrophages, the microglia, the unique cerebrovascular endothelium and angiogenesis.


Understanding human disease is the goal of much of this research. New discoveries are being made and reported at a gratifying rate. It is expected that this volume will promote the steady production and application of useful new knowledge in this developing field. It provides a unique single-source database for basic neurobiology highlighting the fundamental aspects of chemokines and discussing the relations of chemokine science to animal models and human disease.

Computational Molecular Modelling in Structural Biology, Volume 113 (Hardcover): Tatyana Karabencheva-Christova, Christo... Computational Molecular Modelling in Structural Biology, Volume 113 (Hardcover)
Tatyana Karabencheva-Christova, Christo Christov
R3,710 Discovery Miles 37 100 Ships in 10 - 15 working days

Computational Molecular modelling in Structural Biology, Volume 113, the latest release in the Advances in Protein Chemistry and Structural Biology, highlights new advances in the field, with this new volume presenting interesting chapters on charting the Bromodomain BRD4: Towards the Identification of Novel Inhibitors with Molecular Similarity and Receptor Mapping, and Computational Methods to Discover Compounds for the Treatment of Chagas Disease.

Phagocytosis: The Host, Volume 5 (Hardcover): S. Gordon Phagocytosis: The Host, Volume 5 (Hardcover)
S. Gordon
R2,768 Discovery Miles 27 680 Ships in 10 - 15 working days

An accompanying volume (Volume 6) in this series presents strategies of cellular invasion from the viewpoint of the microbe.
This filed of study is growing rapidly after a somewhat slow start over recent decades. This collection of invited chapters attempts to reflect current research, and brings together cell biologists, microbiologists and immunologists with disparate interests. However, there is a certain unity, even repetition of key themes, hopefully like a symphony rather than a boring catalogue. It will be evident that editorial bias favors intracellular paratism and medically important organisms. The neutrophil is far more than a supporting player to the macrophage, and some attempt is made to remind the reader of some of its unique skills. To retain a manageable size, the emphasis is on relatively early events such as mutual recognition, cell entry, and response, rather than on longterm changes in gene expression by either host cell or pathogen. Viruses are excluded not because of lack of importance but because of somewhat different research approaches, although it is cytogenes, share common strategies in invasion and intercellular spread.

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