An all-in-one practical guide on how to efficiently use chromatographic separation methods Based on a training course that teaches the theoretical as well as practical aspects of protein bioseparation to bioprocess professionals, this fully updated and revised new edition offers comprehensive coverage of continuous chromatography and provides readers with many relevant examples from the biopharmaceutical industry. Divided into two large parts, Protein Chromatography: Process Development and Scale-Up, Second Edition presents all the necessary knowledge for effective process development in chromatographic bioseparation, both on small and large scale. The first part introduces chromatographic theory, including process design principles, to enable the reader to rationalize the set-up of a bioseparation process. The second part illustrates by way of case studies and sample protocols how the theory learned in the first part may be applied to real-life problems. Chapters look at: Downstream Processing of Biotechnology Products; Chromatography Media; Laboratory and Process Columns and Equipment; Adsorption Equilibrium; Rate Processes; and Dynamics of Chromatography Columns. The book closes with chapters on: Effects of Dispersion and Rate Processes on Column Performance; Gradient Elution Chromatography; and Chromatographic Column Design and Optimization. -Presents the most pertinent examples from the biopharmaceutical industry, including monoclonal antibodies -Provides an overview of the field along with design tools and examples illustrating the advantages of continuous processing in biopharmaceutical productions -Focuses on process development and large-scale bioseparation tasks, making it an ideal guide for the professional bioengineer in the biotech and pharma industries -Offers field-tested information based on decades of training courses for biotech and chemical engineers in Europe and the U.S. Protein Chromatography: Process Development and Scale-Up, Second Edition will appeal to biotechnologists, analytical chemists, chromatographers, chemical engineers, pharmaceutical industry, biotechnological industry, and biochemists.

Biologically active natural products and their substructures have long been valuable starting points for medicinal chemistry and drug discovery. This new volume explores biologically active natural products and their use in microbial technologies and as phyto-pharmaceuticals in drug development. It presents detailed scientific principles and recent research on applications of nanotechnology in diagnostics and drug delivery. Topics include pharmacotherapeutically active proteins and peptides; the biotechnological potential of hydrogen-oxidizing bacteria; synthesis and production; synthetic colorants, pigments, dyes, and lakes; and more. The use of various plants is discussed in several chapters, including Artemisia, Asteraceae, Abutilon indicum, Prosopis juliflora, Acacia arabica, Aloe barbadensis, Tabermontana divaricate Linn., among others. With the information presented in Biologically Active Natural Products: Microbial Technologies and Phyto-Pharmaceuticals in Drug Development, scientists, faculty, and graduate students will gain a unique insight into nanotechnology and natural pharmaceuticals today with practical implementation in various industrial sectors.

By providing an applied and modern approach, this volume will help readers understand the value and relevance of studying chemical physics and technology to all areas of applied chemical engineering, and gives them the depth of coverage they need to develop a solid understanding of the key principles in the field. Presenting a wide-ranging view of current developments in applied methodologies in chemical and biochemical physics research, the papers in this collection, all written by highly regarded experts in the field, examine various aspects of chemical and biochemical physics and experimentation. The book: * Highlights applications of chemical physics to subjects that chemical engineering students will see in graduate courses * Introduces the types of challenges and real problems that are encountered in industry and graduate research * Provides short chapters that introduce students to the subject in more bite-sized pieces * Presents biochemical examples and applications * Focuses on concepts above formal experimental techniques and theoretical methods The book is ideal for upper-level research students in chemistry, chemical engineering, and polymers. The book assumes a working knowledge of calculus, physics, and chemistry, but no prior knowledge of polymers.

This second review volume is a follow-up to the book "Engineering of Chemical Complexity" that appeared in 2013. Co-edited by the Nobel laureate Gerhard Ertl, this book provides a broad perspective over the current research aimed at understanding, the design and control of complex chemical systems of various origins, on the scales ranging from single molecules and nano-phenomena to macroscopic chemical reactors. Self-organization behavior and emergence of coherent collective dynamics in reaction-diffusion systems, in active soft matter and biochemical networks are discussed. Special attention is paid to applications in cell biology, to molecular motors and microfluidics effects. The reviews, prepared by leading international experts from the EU, USA, Russia and Japan, together yield a fascinating picture of a rapidly developing research discipline that brings chemical engineering to new frontiers.

Exposes a Powerful Material-Making Tool Dedicated to the physical, chemical, and structural transformations that take place during combustion synthesis (CS) of advanced materials, Combustion for Material Synthesis analyzes the nature of solid flame phenomenon and provides readers with undisputed proof that 'fire' is a powerful tool used in making materials. Of interest to specialists in the field of materials engineering, this book explores the physical and chemical principles of synthesis of materials in the self-sustained combustion mode. It describes mechanisms for a variety of solid-solid and gas-solid reactions and examines structure and properties of different materials produced by CS. The authors discuss a wide range of topics, including phenomenology, theory, experimental methods and observations, as well as properties of the product synthesized and approaches for large-scale materials production using the combustion synthesis technique. They examine conventional concepts and present recent breakthroughs in the field of materials synthesis by rapid self-sustained reactions that include fabrication of different nanomaterials. They compare CS with other methods, factoring in different types of combustion processes, including processes that can occur in a vacuum, inert gas, or oxygen-free atmosphere. Covering research on topics that have been around for a while, but not widely circulated, this work: Outlines in detail both fundamental aspects of CS, including modern theoretical approaches and advanced in situ experimental methods Examines the advantages and disadvantages, achievements, and challenges remained in heterogeneous combustion used for material synthesis Explores the emergence of a new fundamental direction in material science, i.e., structural macrokinetics Details new technologies that are based on fundamental scientific discoveries and innovative scientific ideas Analyzes structure and properties of variety of CS materials, including nanomaterials Authored by world-recognized specialists in the field of combustion synthesis for advanced materials, Combustion for Material Synthesis presents the state of the art in R&D in the field of CS, focusing on the fabrication of novel materials. It is intended for researchers, engineers, and graduate students from different disciplines and is also suggested as recommended reading for materials science courses.

A range of factors must be considered when developing a topical antimicrobial for use in a healthcare personnel handwash, surgical scrub, or preoperative skin preparation. Antimicrobial effectiveness, low skin irritation, ease of use, and pleasing aesthetics are all essential if the product is to succeed. In addition, all facets of the product must comply with stringent regulatory requirements. With updated protocols and research, Topical Antimicrobials Testing and Evaluation, Second Edition comprehensively presents and reviews the latest techniques for testing antimicrobial compounds for effectiveness and regulatory compliance. Topics include: The anatomical structure of the skin and skin microbiology relevant to product testing Use of antimicrobial products against specific microorganisms such as Staphylococcus and Streptococcus species Measurement of antimicrobial action of topical antimicrobials from experimental design, microbiological, biostatistical, and marketplace perspectives Various aspects of the topical antimicrobial products currently in common use in medical, food service, and consumer markets Statistical analysis and specific statistical designs for clinical trials Epistemological requirements in evaluating the effects of specific treatments Evaluation strategies and sample working protocols for hand and body soaps, food-handler antimicrobial products, and medical/healthcare industry antimicrobial products The book is designed to inform industry and academia on the requirements to get products approved by the FDA and to market while also providing critical insight on ways to best service expanding markets.

Progress in Filtration and Separation contains reference content on fundamentals, core principles, technologies, processes, and applications. It gives detailed coverage of the latest technologies and research, models, applications and standards, practical implementations, case studies, best practice, and process selection. Extensive worked examples are included that cover basic calculations through to process design, including the effects of key variables. Techniques and topics covered include pervaporation, electrodialysis, ion exchange, magnetic (LIMS, HIMS, HGMS), ultrasonic, and more.

Teaches Readers How to Apply a Structured Problem-Solving Methodology for Industrial Fields Based on Sound Scientific Principles As modern industrial processes have become increasingly complex, complicated multi-factor problems have emerged. These complex problems end up costing companies millions of dollars every day. Existing problem-solving techniques are only effective to a certain point. This book provides a solution to a myriad of industrial problems by using first principles and rigorous hypothesis testing. Key topics covered within the work include: How to use the latest research, advanced modeling, big data mining, analytical testing, and many other techniques to systematically create and test hypotheses surrounding why a process is malfunctioning How to use scenario development to frame a team's understanding of why a process is malfunctioning How to approach today's lack of experienced industrial workers, whose failure to approach problem solving from first fundamentals are causing myriad of inefficiencies in industry How to use multiple methodologies together with an emphasis on first principles and mechanistic math modeling as a basis to industrial problem solving Engineers of any discipline working in both research and development of manufacturing environments, along with professionals in any industrial discipline looking to reduce costs will be able to use this work to both understand and pragmatically solve the pressing issues we see in today's industrial market.

This comprehensive work shows how to design and develop innovative, optimal and sustainable chemical processes by applying the principles of process systems engineering, leading to integrated sustainable processes with 'green' attributes. Generic systematic methods are employed, supported by intensive use of computer simulationas a powerful tool for mastering the complexity of physical models.

New to the second edition are chapters on product design and batch processes with applications in specialty chemicals, process intensification methods for designing compact equipment with high energetic efficiency, plantwide control for managing the key factors affecting the plant dynamics and operation, as well as sustainability analysis for achieving high environmental performance. All chapters are completely rewritten or have been revised.

This new edition is suitable as teaching material for Chemical Process and Product Design courses for graduate MSc students, being compatible withacademic requirements world-wide.The inclusion of the newest design methodswill be of great value to professional chemical engineers.
Systematic approach to developing innovative and sustainable chemical processes Presents generic principles of process simulation for analysis, creation and assessmentEmphasis on sustainable development for the future of process industries"

Fuel Production with Heterogeneous Catalysis presents the groundbreaking discoveries, recent developments, and future perspectives of one of the most important areas of renewable energy research-the heterogeneous catalytic production of fuels. Comprised of chapters authored by leading experts in the field, this authoritative text: Focuses primarily on the state-of-the-art catalysts and catalytic processes anticipated to play a pivotal role in the production of fuels Describes production of fuels from renewable sources using environmentally friendly technologies Exposes the advantages and disadvantages of each production process Suggests solutions to minimize the impact of fuel transportation Conveys the importance of catalysis for the sustainable production of fuels Fuel Production with Heterogeneous Catalysis delivers a comprehensive overview of the current state of the art of the heterogeneous catalytic production of fuels, providing reaction mechanism schemes, engineering solutions, valuable industry insights, and more.

"Voids in Materials" treats voids of different shapes and forms in various materials, and examines their effects on material properties. The book covers the origins of voids in materials, how they are sometimes introduced in the form of hollow spheres, and the resultant properties of materials containing voids.

There are many books that focus on foams (which intentionally incorporate voids into materials) and that cover voids incidental to or unwanted in the fabrication of non-porous materials. In fact, all materials have voids. This book starts from the premise that voids are pervasive in all material on some level. It goes beyond foams to provide a comprehensive overview of voids, a central reference for scientists and engineers to use for the effect of voids in materials.
Includes 3D renderings of void geometriesExplains how and why voids are introduced into materials across the length scales; from nanometer-scale voids up to macro-scale voidsProvides a continuous picture of how material properties change as the volume fraction of voids increases, and the implications for product design

In the recent decades, the emerging new molecular measurement techniques and their subsequent availability in chemical database has allowed easier retrieval of the associated data by the chemical analyst. Before the data revolution, most books focused either on mathematical modeling of chemical processes or exploratory chemometrics. Computational and Statistical Methods for Chemical Engineering aims to combine these two approaches and provide aspiring chemical engineers a single, comprehensive account of computational and statistical methods. The book consists of four parts: Part I discusses the necessary calculus, linear algebra, and probability background that the student may or may not have encountered before. Part II provides an overview on standard computational methods and approximation techniques useful for chemical engineering systems. Part III covers the most important statistical models, starting from simple measurement models, via linear models all the way to multivariate, non-linear stochiometric models. Part IV focuses on the importance of designed experiments and robust analyses. Each chapter is accompanied by an extensive selection of theoretical and practical exercises. The book can be used in combination with any modern computational environment, such as R, Python and MATLAB. Given its easy and free availability, the book includes a bonus chapter giving a simple introduction to R programming. This book is particularly suited for undergraduate students in Chemical Engineering who require a semester course in computational and statistical methods. The background chapters on calculus, linear algebra and probability make the book entirely self-contained. The book takes its examples from the field of chemistry and chemical engineering. In this way, it motivates the student to engage actively with the material and to master the techniques that have become crucial for the modern chemical engineer.

Recent studies indicate that China accounts for about 96 percent of the world's supply of rare earth materials (REMs). With REMs becoming increasingly important for a growing number of high-tech applications, appropriate action must be taken to mitigate the effects of a shortage of critical REMs in defense systems and components. Bringing together information previously available only from disparate journal articles and databases, Rare Earth Materials: Properties and Applications describes the unique characteristics and applications of 17 REMs. It defines their chemical, electrical, thermal, and optical characteristics. Maintaining a focus on physical and chemical properties, it addresses the history and critical issues pertaining to mining and processing of REMs. In this book, Dr. A.R. Jha continues his distinguished track record of distilling complex theoretical physical concepts into an understandable technical framework that can be extended to practical applications across commercial and industrial frameworks. He summarizes the chemical, optical, electrical, thermal, magnetic, and spectroscopic properties of REMs best suited for next-generation commercial and military systems or equipment. Coverage includes extraction, recycling, refinement, visual inspection, identification of spectroscopic parameters, quality control, element separation based on specific application, pricing control, and environmental / geo-political considerations. Potential applications are identified with an emphasis on scientific instruments, nuclear resonance imaging equipment, MRI systems, magnetic couplers for uranium enrichment equipment, battery-electrodes, electric motors, electric generators, underwater sensors, and commercial and military sensors. The book describes unique applications of rare earth magnets in all-electric and hybrid electric cars and microwave components. It also considers the use of rare earth magnets in commercial and military systems where weight and size are the critical design requirements. Suitable for both students and design engineers involved in the development of high-technology components or systems, the book concludes by summarizing future applications in electro-optic systems and components, including infrared lasers, diode-pumped solid-state lasers operating at room temperatures, and other sophisticated military and commercial test equipment

The aim and purpose of this book is to provide an understanding of the current science underpinning Carbon Capture and Sequestration (CCS) and to provide students and interested researchers with sufficient background on the basics of chemical engineering, material science, and geology that they can understand the current state of the art of the research in the field of CCS. In addition, the book provides a comprehensive discussion of the impact on CCS on the energy landscape, society, and climate as these topics govern the success of the science being done in this field. The book is aimed at undergraduate students, graduate students, scientists, and professionals who would like to gain a broad multidisciplinary view of the research that is being carried out to solve one of biggest challenges of our generation.

Compiled by an expert in the field, the book provides an engineer with data they can trust. Spanning gases, liquids, and solids, all critical properties (including viscosity, thermal conductivity, and diffusion coefficient) are covered.

From C1 to C100 organics and Ac to Zr inorganics, the data in this handbook is a perfect quick reference for field, lab or classroom usage. By collecting a large - but relevant - amount of information in one source, the handbook enables engineers to spend more time developing new designs and processes, and less time collecting vital properties data. This is not a theoretical treatise, but an aid to the practicing engineer in the field, on day-to-day operations and long range projects.
Simplifies research and significantly reduces the amount of time spent collecting properties data
Compiled by an expert in the field, the book provides an engineer with data they can trust in design, research, development and manufacturing.
A single, easy reference for critical temperature dependent properties for a wide range of hydrocarbons, including C1 to ClOO organics and Ac to Zr inorganics

Advances in Energy, Environment and Chemical Engineering collects papers resulting from the conference on Energy, Environment and Chemical Engineering (AEECE 2022), Dali, China, 24-26 June, 2022. The primary goal is to promote research and developmental activities in energy technology, environment engineering and chemical engineering. Moreover, it aims to promote scientific information interchange between scholars from the top universities, business associations, research centers and high-tech enterprises working all around the world. The conference conducts in-depth exchanges and discussions on relevant topics such as energy engineering, environment technology and advanced chemical technology, aiming to provide an academic and technical communication platform for scholars and engineers engaged in scientific research and engineering practice in the field of saving technologies, environmental chemistry, clean production and so on. By sharing the research status of scientific research achievements and cutting-edge technologies, it helps scholars and engineers all over the world comprehend the academic development trend and broaden research ideas. So as to strengthen international academic research, academic topics exchange and discussion, and promote the industrialization cooperation of academic achievements.

Fulfilling the need for a classical approach, Experimental Combustion: An Introduction begins with an overview of the key aspects of combustion including chemical kinetics, premixed flame, diffusion flame, and liquid droplet combustion followed by a discussion of the general elements of measurement systems and data acquisition and analysis. In addition to these aspects, thermal flow measurements, gas composition measurements, and optical combustion diagnostics are covered extensively.

Building upon this foundation in the fundamentals, the text addresses measurements, instruments, analyses, and diagnostics specific to combustion experiments, as well as:

• Describes the construction, working principles, application areas, and limitations of the necessary instruments for combustion systems
• Familiarizes the reader with the procedure for uncertainty analysis in combustion experiments
• Discusses advanced optical techniques, namely particle image velocimetry (PIV), laser Doppler anemometry (LDA), and planar laser-induced fluorescence (PLIF) methods

From stoichiometry to smoke meters and statistical analysis, Experimental Combustion: An Introduction provides a solid understanding of the underlying concepts and measurement tools required for the execution and interpretation of practical combustion experiments."

By far the most commonly encountered and energy-intensive unit operation in almost all industrial sectors, industrial drying continues to attract the interest of scientists, researchers, and engineers. The Handbook of Industrial Drying, Fourth Edition not only delivers a comprehensive treatment of the current state of the art, but also serves as a consultative reference for streamlining industrial drying operations. New to the Fourth Edition: Computational fluid dynamic simulation Solar, impingement, and pulse combustion drying Drying of fruits, vegetables, sugar, biomass, and coal Physicochemical aspects of sludge drying Life-cycle assessment of drying systems Covering commonly encountered dryers as well as innovative dryers with future potential, the Handbook of Industrial Drying, Fourth Edition not only details the latest developments in the field, but also explains how improvements in dryer design and operation can increase energy efficiency and cost-effectiveness.

Used lubricating oil is a valuable resource. However, it must be re-refined mainly due to the accumulation of physical and chemical contaminants in the oil during service. Refining Used Lubricating Oils describes the properties of used lubricating oils and presents ways these materials can be re-refined and converted into useful lubricants as well as other products. It provides an up-to-date review of most of the processes for used lubricating oil refining that have been proposed or implemented in different parts of the world, and addresses feasibility and criteria for selecting a particular process. The book begins with an overview of lubricating oil manufacturing, both petroleum-based and synthetic-based. It reviews the types and properties of lubricating oils and discusses the characteristics and potential of used lubricating oils. The authors describe the basic steps of used oil treatment including dehydration, distillation or solvent extraction, and finishing. They explore the combustion of used oil for use as fuel, covering chemistry and equipment, fuel oil properties, and combustion emissions. The book considers alternative processing options such as refinery processing and re-refining. It also reviews the major refining processes that have been suggested over the years for used oil. These include acid/clay, simple distillation, combinations of distillation and hydrogenation, solvent extraction, filtration, and coking processes. The book addresses economic, life cycle assessment, and other criteria for evaluating the attractiveness of an oil recycling project, examining various costs and presenting an economic evaluation method using an Excel spreadsheet that can be downloaded from the publisher's website. The book concludes with a chapter offering insights on how to choose the most suitable process technology.

Numerical simulation of multiphase reactors with continuous liquid phase provides current research and findings in multiphase problems, which will assist researchers and engineers to advance this field. This is an ideal reference book for readers who are interested in design and scale-up of multiphase reactors and crystallizers, and using mathematical model and numerical simulation as tools.

Yang and Mao s book focuses on modeling and numerical applications directly in the chemical, petrochemical, and hydrometallurgical industries, rather than theories of multiphase flow. The content will help you to solve reacting flow problems and/or system design/optimization problems. The fundamentals and principles of flow and mass transfer in multiphase reactors with continuous liquid phase are covered, which will aid the reader s understanding of multiphase reaction engineering.
Provides practical applications for using multiphase stirred tanks, reactors, and microreactors, with detailed explanation of investigation methods.Presents the most recent research efforts in this highly active field on multiphase reactors and crystallizers. Covers mathematical models, numerical methods and experimental techniques for multiphase flow and mass transfer in reactors and crystallizers. "

This volume, Bioresponsive Polymers: Design and Application in Drug Delivery, focuses on recent advancements in bioresponsive polymers and their design, characterization, and applications in varied fields, such as drug delivery and gene delivery. It looks at several carriers for drug delivery and biological molecules using different bioresponsive polymers. To address the many difficulties in existing dosage forms, this book provides information on recent developments to overcome drawbacks of conventional forms of the drug delivery. The chapters cover most areas of bioresponsive polymers, starting with a basic introduction to bioresponsive polymers, followed by chapters on design, characterization, and mechanism of bioresponsive polymers; and applications of drug and gene delivery using bioresponsive polymers via oral, topical, nasal, ocular, and parenteral methods. The book also reviews recent advancements in bioresponsive polymers and advanced applications, such as engineering particulate moieties, biomedical applications, hydrogels as emerging therapy, and electrochemical responses, bioresponsive nanoparticles, and bioresponsive hydrogels.

This volume is part of a continuing series that provides authoritative reviews on recent developments and applications of well-established techniques in the field of electroanalytical chemistry. Each volume provides the necessary background and starting point for graduate students undertaking related research projects and is of special interest to practicing analytical chemists concerned with electroanalytical techniques. Volume 27 continues this tradition with innovative contributions from internationally respected scientists who highlight new technologies and trends in Protein Biosensing, Bipolar Electrochemistry, and X-ray Absorption Spectroscopy in Electrochemistry.

The aim and purpose of this book is to provide an understanding of the current science underpinning Carbon Capture and Sequestration (CCS) and to provide students and interested researchers with sufficient background on the basics of chemical engineering, material science, and geology that they can understand the current state of the art of the research in the field of CCS. In addition, the book provides a comprehensive discussion of the impact on CCS on the energy landscape, society, and climate as these topics govern the success of the science being done in this field. The book is aimed at undergraduate students, graduate students, scientists, and professionals who would like to gain a broad multidisciplinary view of the research that is being carried out to solve one of biggest challenges of our generation.

This book, Chemistry and Industrial Techniques for Chemical Engineers, brings together innovative research, new concepts, and novel developments in the application of new tools for chemical and materials engineers. It contains significant research, reporting new methodologies, and important applications in the fields of chemical engineering as well as the latest coverage of chemical databases and the development of new methods and efficient approaches for chemists. With clear explanations, real-world examples, this volume emphasizes the concepts essential to the practice of chemical science, engineering, and technology while introducing the newest innovations in the field.

In the process industry, shutdown and turnaround costs are responsible for an excessive amount of maintenance expenses. Process Plants: Shutdown and Turnaround Management explores various types of shutdowns, presents recommendations for better management, and offers feasible solutions to help reduce overheads. Because turnaround management is the largest maintenance activity, plant turnaround is the focal point of this text. The book details a plan to lengthen the interval between turnarounds, and curtail costs in process production management by at least 30 percent.

This practical guidebook provides a thorough study of shutdown management, discusses different types of shutdown and managing events (emergency, unplanned, planned, and turnaround), and covers all aspects of plant turnaround management including startup, shutdown, and maintenance. It describes the five phases of shutdown management initiating, planning, executing, controlling, and closing. It contains specific principles and precautions for successful shutdown planning, and highlights many aspects including turnaround philosophy, planning and scheduling, estimation, contractor management, execution, safety management, managing human resources, and post shut down review.

Process Plants: Shutdown and Turnaround Management also includes topical information that readers can successfully apply to future shutdown projects. It is suitable for industry professionals and graduate students."