Heme oxygenases (HOs) are the enzymes responsible for the breakdown of heme and the generation of biliverdin/bilirubin and carbon monoxide (CO). The kidney is a complex organ consisting of many different cell types all working together for the single purpose of filtering the blood to eliminate waste products and conserving ions, minerals, and water necessary for life. HO enzymes and their products play a critical role in the normal function of the kidney as well as protecting the kidney from various insults including ischemia and exposure to nephrotoxins. For example, the HO metabolite, bilirubin, is a potent antioxidant which can limit damage to renal tubular epithelial cells following exposure to nephrotoxins associated with chemotherapy or traumatic injury. Another HO metabolite, CO, is an important vasodilator of renal blood vessels and helps protect against severe decreases in renal blood flow in conditions as diverse as exposure to radiocontrast agents and in hypertension-induced kidney disease. HO and its metabolites also play an important role in the survival of kidney cells after acute and chronic injuries by regulating important cell growth and programmed cell death pathways. The intent of this volume is to highlight the important role that HO enzymes and their related metabolites, bilirubin and CO, play in the regulation of renal function and in the response of the kidney to both acute and chronic pathologies. Table of Contents: Introduction to the HO System / HO and Renal Vascular Function / HO and Renal Tubule Function / HO and Acute Kidney Injury / HO and Chronic Kidney Injury / Future of Renal HO Research / References

This unique volume may very well foreshadow the treatment of renal disease in the twenty-first century. The editors have obviously compiled and reviewed the current clinical problems in which the kidney plays a major role. They then selected as topics for chapters those in which recent scientific investigations have added significant new data. The investigators themselves or their peers have been persuaded to produce a summary of current concepts of renal structure and function for each topic. The result is a volume which will be as invaluable as a clinical guide on the laboratory bench as it will be a reference for the clinician seeking guidance to rational therapy at the bedside. The strength of the volume lies in the incorporation of those data on renal cellular structure and function which hold the key to the etiology of the majority of renal diseases we now call 'end-stage'. Fully, two-thirds of the volume is devoted to current concepts of renal function and related subcellular structure of various renal tissues. The illustrations, correlations, and explanations are superbly presented in much detail and with an obvious effort to fill out the current knowledge of each subject. We may anticipate this book will remain a valuable reference for many years to come.

This official publication of the National Kidney Foundation (NKF) covers all aspects of adult and pediatric kidney diseases and is ideal for nephrologists and non-nephrologists alike. The full-color design, high-quality photographs, and outstanding graphs and tables make information easy to access and understand. The latest management techniques and pearls from leading clinical experts - including international contributors - offer practical and authoritative guidance. Edited by Dr. Arthur Greenberg and members of the NKF Scientific Advisory Board, this state-of-the-art primer provides consistent depth of coverage, balanced discussion of controversy, and a uniform focus of information.

Every Year, High Blood Pressure Causes More Than 25,000 New Cases Of Kidney Failure In The United States. 100 Questions & Answers About Kidney Disease And Hypertension Offers Authoritative, Up-To-Date, Practical Answers About Kidney Disease, End-Stage Kidney Failure, Transplants, And Dialysis. The Book Is An Invaluable Resource For Anyone Coping With The Physical And Emotional Turmoil Of This Condition.

Little Black Book Of Nephrology And Hypertension Is A Comprehensive Pocket Reference To All Aspects Of Kidney Disease. This Convenient Resource Offers Quick Access To Vital Information And Makes A Great Reference For Solving Pressing Problems On The Ward Or In The Clinic.

This scarce antiquarian book is included in our special Legacy Reprint Series. In the interest of creating a more extensive selection of rare historical book reprints, we have chosen to reproduce this title even though it may possibly have occasional imperfections such as missing and blurred pages, missing text, poor pictures, markings, dark backgrounds and other reproduction issues beyond our control. Because this work is culturally important, we have made it available as a part of our commitment to protecting, preserving and promoting the world's literature.

This manual contains protocols and guidance documents assembled by the authors during many years of clinical experience in nephrology. Many are not evidence-based but we have found them useful and hope that others will do likewise. The recommendations were made on the basis of clinical trials wherever possible. In the absence of relevant clinical trials, we used evidence available or our personal experience. Our aim was to provide a manual for the treatment of the most frequent kidney diseases or disorders related to the practice of Nephrology. The information may be of use to nephrologists, general internists, general practitioners or medical students.

This story depicts the love of two soul mates and the miracle of life that was given: a kidney. She knows a "higher power" allows unbelievable things to happen. Their lives together survive the good times and slow times of prosperity, to the diagnosis of kidney failure. From the blue days of his dialysis treatments to the day after surgery, their lives are a true inspiration to those who love "Dialysis Patience" and hope for a donor.

INHALT LANG: Diuretika: Die Harnbildung in der Niere ist ein Vorgang aus Filtration des Blutplasmas und Einengung der filtrierten Flussigkeitsmenge; Diuretika steigern den Harnfluss (Diurese); OEdeme und Hypertonie sind die haufigsten Indikationen fur Diuretika; Unerwunschte Wirkungen von Diuretika sind vor allem Kreislauf-, Elektrolyt- und Stoffwechselstoerungen; Nierenversagen durch Arzneimittel, Umwelt- und Gewerbegifte; Verzeichnis der Handelspraparate.- Renin-Angiotensin-Aldosteron: Renin wird in der Niere freigesetzt, wenn das Plasmavolumen abnimmt und der Blutdruck sinkt; Angiotensin II bewirkt einen Anstieg des Plasmavolumens und des Blutdrucks; Aldosteron foerdert die Resorption von Natrium und die Ausscheidung von Kalium und Protonen uber die Niere; Hyperaldosteronismus kann mit Aldosteron-Antagonisten behandelt werden; ACE-Hemmer spielen eine zentrale Rolle bei der Therapie von Hypertonie und chronischer Herzinsuffizienz; Verzeichnis der Handelspraparate.- Vasopressin: Vasopressin wird im Hypophysenhinterlappen freigesetzt, wenn die Osmolalitat im Plasma steigt und das Plasmavolumen abnimmt; Diabetes insipidus und andere Indikationen fur Vasopressin-Rezeptor-Agonisten; Verzeichnis der Handelspraparate.- Wasser-, Saure-Basen- und Elektrolytgleichgewicht: Volumenanderungen im Extrazellularraum sind primar auf Stoerungen der Wasser- und Natriumbilanz zuruckzufuhren; Stoerungen des Saure-Basengleichgewichts koennen respiratorische und nichtrespiratorische Ursachen haben; Stoerungen des Kaliumgleichgewichts koennen zu lebensbedrohlichen Herzrhythmusstoerungen fuhren; Stoerungen des Calcium- und Magnesiumgleichgewichts beeinflussen muskulare Erregbarkeit und ZNS-Funktionen; Verzeichnis der Handelspraparate.- Literatur.

Why do we sleep? How much sleep do we really need? What causes sleep apnea, narcolepsy, and insomnia-and what can be done about these sleep disorders? Why do older people have more trouble sleeping than young people? We have all puzzled over-or been plagued by-the mysteries of sleep. Now a leading researcher on sleep provides an engaging and informative introduction to the subject that answers many of our questions. Peretz Lavie surveys the entire field of sleep research and sleep medicine-from the structure of sleep stages and the brain centers involved in sleep regulation to the reasons for and significance of dreams, the importance of sleep in maintaining good health, and the function of biological rhythms-interweaving facts with fascinating case histories, anecdotes, and personal reflections. We learn, for example, about: *development of sleep patterns from infancy to adulthood and in the aged; *the wide variety of sleep habits in animals; *dreams of Holocaust survivors; *sleep under the threat of Scud missile attacks; *how melatonin influences sleep; *the story of the "Acrobat's Leap" sleep-deprivation experiments in the Israeli army; *how to treat insomnia; *what to do with a baby who refuses to go to sleep; and much more. Originally published in Hebrew to great acclaim, this book will enlighten and entertain everyone interested in how and why we sleep.

The Oxford Handbook of Dialysis is a comprehensive and practical guide to all aspects of dialysis, the management of patients with end stage kidney disease, and all its complications. The fourth edition has been completely updated, and covers all aspects of dialysis from haemodialysis techniques and haemodiafitration, to the medical, nursing and psychosocial aspects of managing patients with end stage kidney failure. Renal transplantation, plasma exchange, palliative care, and drug dosing are discussed, along with end of life care, and complications of chronic kdney disease. This handbook is packed with practical guidance and management, presented in a compact and easy to use format. The Oxford Handbook of Dialysis is aimed at all health care professionals dealing with dialysis patients from nephrologists to dieticians, as well as pharmacists, nurses, and surgeons. There are specific chapters on nursing patients on haemodialysis and peritoneal dialysis, and detailed nutrition and drug prescribing chapters. The fourth edition includes new sections on renal replacement therapies in acute kidney injury, home dialysis, new peritoneal dialysis fluids, new drugs including new epoietins and phosphate binders, updated sections on nocturnal dialysis, dialysis monitoring, encapsulating peritoneal sclerosis, and sleep disorders. Easy to read, practical, and focussed, this handbook should have a home in every renal unit, dialysis centre, renal ward, and be close to hand for every nephrologist, renal trainee, or renal nurse.

The congress of the International Society of Nephrology is held every three years. These comprehensive proceedings of the congress held in Tokyo in 1990 document the progress made in this field since the previous congress. This book of proceedings on nephrology is intended for researchers and clinicians.

This unique book reviews the information available in the literature regarding the new syndrome, frailty, in patients with various renal conditions, such as acute kidney injury, chronic kidney disease, as well as dialysis and transplant patients. The topic is of importance in nephrology, specifically nephrogeriatrics, since frailty is a condition affecting many elderly patients and which is becoming increasingly common in medical practice. As such, there is a considerable need for information to assist professionals treating these patients. The book includes chapters on the frailty syndrome (definition, evaluation and treatment), the main geriatric syndromes (gait disorder, falls, incontinence, and delirium), the main renal syndromes (acute renal injury, chronic kidney disease) as well as dialysis and kidney transplant, and the relationship between geriatrics and renal syndromes. Frailty and Kidney Disease: A Practical Guide to Clinical Management is an essential resource for general practitioners, researchers, internal medicine physicians, geriatricians, and nephrologists.

The third edition of a bestseller, this book provides insight from a wide array of international contributors in the field of pediatric nephrology. Copiously illustrated with photomicrographs and clinical diagrams, the third edition reflects current advances in the field. Each chapter contains a set of questions, directed at helping fellows succeed at the American Pediatric Nephrology Board examination. New information for this edition includes changes in treatment options for hyponatremia, and updates on hyperparathyroidism and transplantation. Text boxes highlight important "take home points" throughout the chapters. Clinical Pediatric Nephrology, Third Edition will be a valuable reference for clinicians in nephrology, pediatrics and urology, and any professional involved in the care of children with renal diseases seeking a reliable contemporary text.

Kidney transplantation is a medical procedure performed on patients with end-stage kidney disease that can increase their life expectancy by several years. However, the procedure involves some risk and potential complications. Chapter One of this monograph summarizes the current strategy for diagnosis and treatment of chronic kidney disease-associated mineral bone disease (CKD-MBD) in kidney transplant recipients and aims to demonstrate the latest findings and therapeutic options in the field beyond recent published guidelines. Chapter Two describes the necessity of involving a psychiatrist in the transplant team to facilitate positive outcomes in kidney transplants, as psychological factors can contribute to treatment non-compliance and other issues. Chapter Three defines the surgical techniques used in living donor nephrectomy, discusses the use and reliability of these techniques in different patient groups, and examines the long-term follow-up results of donors and recipients. Lastly, Chapter Four discusses the variables involved in treating patients with autosomal dominant polycystic kidney disease (ADPCKD), whose enlarged and deformed kidneys can complicate kidney transplantation.

This handbook on vacuolar and plasma membrane H+-ATPases is the first to focus on an essential link between vacuolar H+-ATPase and the glycolysis metabolic pathway to understand the mechanism of diabetes and the metabolism of cancer cells. It presents recent findings on the structure and function of vacuolar H+-ATPase in glucose promoting assembly and signaling, in addition to describing the regulatory mechanisms of vacuolar H+-ATPase in yeast cells, neural stem cells, kidney cells, cancer cells, as well as under diabetic conditions.

This book provides a concise yet comprehensive overview of acid-base disorders. Each chapter reviews an acid-base disorder, covering pathophysiology, evaluation, and management of the disorder. The chapters also include clinical cases and a Q&A section, based on scenarios and questions that clinicians regularly encounter when treating patients with these disorders. The book concludes with two chapters on acid-based disorders in special patient populations, including critically ill patients, pregnant patients, and surgical patients. Written by an expert in the field, Acid-Base Disorders: Clinical Evaluation and Management is a state-of-the-art resource that should assist clinicians and practitioners in managing patients with acid-base disorders.

Zur Untersuchung des Einflusses von tubularem HIF auf die renale EPO-Produktion generierte Navid Farsijani ein genetisches Mausmodell, in dem durch tubulare Vhl-Ablation, tubulare Epithelzellen HIF uberexprimieren. Die tubulare Vhl-Ablation fuhrte zu einer prompten Suppression der renalen EPO-Produktion. Anhand weitere konditioneller Mausmodelle zeigt der Autor, dass die Entwicklung der Anamie von HIF-abhangig ist, proximale Tubuluszellen fur die Regulation von EPO im Nephron verantwortlich sind und die tubulare Vhl-Ablation mit einer Reduktion der mitochondrialen Masse sowie einer Erhoehung des kortikalen Gewebssauerstoffpartialdruckes (PtO2) einhergeht. Dies spricht fur eine multi-zellulare Regulation der renalen EPO-Synthese, in der eine Homoeostase zwischen tubularen Epithelzellen und REPC fur eine adaquate EPO-Produktion der Niere notwendig ist. Zudem koennte der EPO-suppressive Effekt von tubularem HIF einen pathophysiologischen Faktor in der Entstehung von renalen Anamien darstellen.

Written by an interdisciplinary team of experts, this book contains historical information as well as current update on renal replacement therapy. New technology and techniques are presented in a concise, easy-to-read style that keeps the reader interested.

The contributors include physicians who practise uremia therapy since its conception to more recent graduates, along with surgeons, pioneers and physicians who are patients themselves, thus giving readers the broadest perspective.

The aim of the book is to update the reader on renal replacement therapy as of 2009. It is a textbook that can be read cover to cover and still serve as a fine reference guide. The book is targeted at anyone interested in kidney replacement therapy, from students and patients to the professorial level.

Adenocarcinoma is the predominant malignancy found in the colon and rectum. Colorectal cancer is the third most common cancer diagnosed in the developed world with a high incidence of mortality and morbidity. The average five-year survival rate remains poor at 55%, although the development of new drugs has improved the survival rate of colorectal cancer patients. The prognosis of colorectal cancer remains poor in spite of the development of novel therapeutic strategies. Human colorectal cancer represents a heterogeneous group of diseases, and its molecular classification is increasingly important. Characterization of novel biomarker targets may lead to prolong the survival rate of colorectal cancer. Biomarkers may have a potential role in screening, diagnosis, prognosis and monitoring disease. Mutations in the KRAS gene in ~40% of tumors have been reported to be induced by genetic and epigenetic alterations. This book, comprised of four chapters, introduces recent topics regarding colorectal cancer, and provides recent highlighted information concerning prevention, diagnosis and treatment. This book will be of interest to undergraduate and graduate students, biomedical researchers, and medical doctors focused on the fields of molecular and cellular biology, medical sciences, and clinical challenges.

Die zweite, komplett uberarbeitete Auflage des Standardwerkes umfasst das gesamte Spektrum der Kinderurologie auf dem neuesten Wissensstand. - Angeborene Fehlformen und Fehlfunktionen der Urogenitalorgane von pranatal bis adult. - Aufgliederung der kongenital-reduktiven Nephropathie nach Dysplasie, Obstruktion und Refluxkrankheit. - Diagnostische und indikatorische Abklarung zwischen konservativer und operativer Therapie, insbesondere der kanzerologischen Krankheiten, der Nephrolithiasis und der Harnableitung. - Padiatrische Nephrologie samt Nierentransplantation, Behandlung der Spaltfehlbildungen der testikularen Erkrankung, der ambivalenten Geschlechtsmerkmale und der urogenitalen Traumatologie des Kindesalters. Zahlreiche Abbildungen, UEbersichten und Tabellen sorgen fur rasche Orientierung. Mit diesem systematischen Nachschlagewerk sind Sie schnell, umfassend und aktuell informiert.

Durch die technische Weiterentwicklung von der einfachen Dopplersonographie bis hin zur farbkodierten Duplexsonographie ist diese Methode in vielen Gebieten der Medizin mittlerweile ein wichtiger Bestandteil der nichtinvasiven Gefassdiagnostik geworden. Die Spezialisierung in der Medizin macht eine fur die einzelnen Fachgebiete differenzierte Literatur auch fur die Duplexsonographie notwendig. In diesem Buch wird deshalb die Anwendung dieser Diagnostik auf dem Gebiet der Nieren- und Hochdruckkrankheiten abgehandelt. Dazu gehort die Diagnostik der renalen Hypertonie, die Erkennung von Komplikationen nach Nierentransplantation sowie die Diagnostik von Dialyseshunts. Damit sind jedoch nicht nur Nephrologen, sondern auch Radiologen und Internisten angesprochen.

Ziel dieses Buches ist es, das bisherige Wissen fiber das Harn- steinleiden umfassend darzustellen und neuere Entwicklun- gen anzusprechen. Aufgrund der speziellen Gliederung des Stoffes muBten einige Aspekte von mehreren Autoren aufge- griffen werden. 1m Interesse einer instruktiven Darstellung aller Kapitel wurden dabei gelegentlich Wiederholungen, im Interesse einer kritischen Darstellung gelegentlich auch kon- troverse Darstellungen in Kauf genommen. Ich hoffe, daB dies den Leser anregt, er aber letztlich immer eine klare Ant- wort auf seine Fragen findet. Weiterffihrende Literatur ist jeweils am Ende eines Kapitels zu finden. Allen Koautoren mochte ich sehr herzlich fUr ihre Mitarbeit und ihr Engagement danken. Auch dem Verlag gehOrt ein Wort des Dankes fUr seine Einsatz- und Hilfsbereitschaft. Ich haffe mit den Kaautaren, daB das Buch eine breite Auf- nahme findet und den Studenten wie allen am Thema interes- sierten Anten zum Wohl unserer Patienten zum Nutzen ist. Bonn, im April 1987 W. Vahlensieck Inhaltsverzeichnis 1 Epidemiologie und Kausalfaktoren (w. Vahlensieck) 1 Literatur. . . . . . . . . . . . . . . . . . . . . . . . 35 2 Formalgenese (w. Dosch) 47 Literatur . . 82 3 Diagnostik . . . . . . . . . . . " 91 3. 1 Spezielle Anamnese (w. Vahlensieck) . . . 91 3. 2 Klinische Untersuchung und bildgebende Verfahren (w. Vahlensieck und D. Bach) . . 99 3. 3 Laboruntersuchungen (W. Vahlensieck, A Hesse und D. Bach) . . . . . . . . . . . . . . . . . . . . 113 3. 4 Harnsteinanalysen. . . . . . . . . . . . . . . . 151 3. 4. 1 Harnsteinanalyse mittels Rontgendiffraktion (M. Gebhardt und K. -F. Seifert) . . . . . . . . . . 151 3. 4. 2 Polarisationsmikroskopische Harnsteinanalyse (A Hesse) . . . . . . . . . . . . . . . . . . . . . . 198 3. 4. 3 Harnsteinanalyse mittels Infrarotspektroskopie (AHesse) . . . . . . . . . . . . . . . . . . . . . 208 3. 4. 4 Rasterelektronenmikroskopie (H. -P. Bastian) . . . 215 Literatur . . . . . . . . 224 4 Harnsteinentfernung . . . . . . .

The first edition of Comorbidities in Chronic Kidney Disease is focused on the main clinical syndromes associated with renal failure. Chronic kidney disease (CKD) and end-stage renal disease (ESRD) are characterized by a wide spectrum of comorbidities, potentially complicating patients clinical outcomes. In this volume, both editor and authors have planned a complete review of the main clinical syndromes associated with renal injury and failure. The first chapter is dedicated to epidemiological aspects of chronic kidney disease, and also introduces risk factors and associated comorbidities. Arterial hypertension and cardiovascular diseases are actually accountable as major risk factors for developing renal disease, and the next chapter is mainly focused on the latest trials in this field. The following chapter is dedicated to pathophysiology, diagnosis and treatment of dyslipidemia and atherosclerosis in patients with declined renal function. The subsequent chapter is exhaustively focused on the clinical features of secondary hyperparathyroidism and the diseases complications on kidneys, bone, vessels and heart, from early laboratory findings to severe vascular and heart valvular calcifications. The section that succeeds reflects on secondary anemia and consequent cardiorenal anemia syndrome with particular attention on the latest treatment schedules. Coronary artery disease is also discussed, especially for those concerned with clinical features and laboratory diagnosis in chronic kidney disease patients with impaired clearance of coronary acute syndrome biomarkers. Cardiorenal syndrome and sudden cardiac death are well-established clinical aspects in CKD patients, and they are discussed both in terms of pathophsysiological and clinical features. The book finally ends with two sections on hepato-renal syndrome and contrast-induced nephropathy (CIN). CIN represents daily challenges for all nephrologists because due to the large amounts of instrumental diagnostic tests and an increasing number of chronic kidney disease patients involved. This volume could be appreciated both by nephrologists and all clinicians involved in chronic patients management due to schematic and practical editing and form.

Das Grundlagenwerk fur Dialyse-Teams

Fur die professionelle Versorgung von Dialysepatienten und Nierenkranken finden Pflegende und medizinische Fachangestellte hier alles Wissenswerte rund um das Gebiet der Nephrologie und Dialyse, u. a.: pflegerische Aufgabenbereiche akuter und chronischer Nierenerkrankungen Ernahrungsempfehlungen bei Dialysepflicht Planung und Organisation der Arbeitsablaufe in Dialyseeinrichtungen Nierentransplantation.

Verstandlich geschrieben, mit zahlreichen Abbildungen, Tabellen und Merksatzen erganzt, eignet sich das Werk hervorragend zum Lernen und Nachschlagen.

• Alle Inhalte der Fachweiterbildung Nephrologie und Dialyse
• Stellenbeschreibungen fur Fachpersonal in der Nephrologie und Dialyse
• Glossar wichtiger Fachbegriffe

Empfohlen von der Deutschen Gesellschaft fur Fachkrankenpflege und Funktionsdienste."