Systemic Lupus Erythematosus (often abbreviated to SLE or lupus) is a systemic autoimmune disease that can affect any part of the body, causing the immune system to attack the body's cells and tissue, and resulting in inflammation and tissue damage. This new addition to the Oxford Rheumatology Library series provides a practical approach to the assessment and management of patients with this complex, multisystem autoimmune disease to improve the diagnosis and treatment of the disease and its complications. It provides comprehensive but easy to assimilate reading for consultant rheumatologists, dermatologists, nephrologists, obstetricians and other specialists and their trainees, interested GPs, specialist nurses, and clinical trial teams both in hospitals and contract research organizations.

Continuous Renal Replacement Therapy (CRRT) is the standard of care for management of critically ill patients with acute renal failure. Part of the Pittsburgh Critical Care series, Continuous Renal Replacement Therapy provides concise, evidence-based, bedside guidance about this treatment modality, offering quick reference answers to clinicians' questions about treatments and situations encountered in daily practice. Organized into sections on theory, practice, special situations, and organizational issues, this volume provides a complete view of CRRT theory and practice. Tables summarize and highlight key points, and key studies and trials are included in each chapter. The second edition has been updated to include a new chapter on the use of biomarkers to aid in patient selection and timing, extensive revisions on terminology and nomenclature to match current standards, and the most up-to-date information on newly developed CRRT machines.

A Proven Plan to Prevent Painful Kidney Stones

At last Whether you are a chronic kidney stone sufferer or at risk of developing stones, this practical, comprehensive guide will help you take charge of your health and eliminate this painful disease from your life forever. Written by a team of experts in the field, No More Kidney Stones includes the latest information on risk factors, dietary and lifestyle choices, and state-of-the-art treatments. It includes:
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Specific, detailed remedies to prevent the formation of the four major types of kidney stones
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Prescriptions for creating a diet that works and dietary troublemakers to avoid
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Treatment options, including Extracorporeal Shock Wave Lithotripsy (ESWL), cystoscopy, ureteroscopy, percutaneous stone surgery, and open surgery
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Case histories showing what types of treatment are appropriate for what specific conditions
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Guidance on what to expect before, during, and after treatment
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Advice on finding the right specialist

Severe inflammation of the kidney can indicate the serious, negative prognosis of lupus nephritis when present in conjunction with systemic lupus erythematosus (SLE), a chronic autoimmune connective tissue disease that can affect any part of the body, most often harming the heart, joints, skin, lungs, blood vessels, liver, kidneys, and nervous system. This book pulls together in one comprehensive reference the current knowledge regarding the inherited and immunologic abnormalities that have been identified in SLE, with specific reference to the development of renal disease and the way in which these factors may impact upon the chronic care of these patients. Since publication of the first edition in 1999, the discipline of medicine has experienced some revolutionary changes in the way drugs are used to treat to immune system diseases. On the basis of careful analysis of physical make-up, the immune system, and microscopic features of the human body, it has become clear that multiple components of the immune system are responsible for renal injury and that any given patient can experience a combination of these mechanisms. With this in mind, specific therapies can be tested, and drugs that interrupt the immune response in highly specific ways are being scrutinized for their value in lupus nephritis. This new edition reflects the updated methods of classification and advances in treatment options for SLE, and covers recent clinical trials to help treat patients using the most up-to-date knowledge available. It takes a practical approach throughout, and will be of interest to those working with patients with lupus nephritis, and those who manage their everyday care.

Moving beyond the science of hemodialysis access, this collection of clinical cases covers procedural and practical aspects of arteriovenous fistula, arteriovenous graft, dialysis catheter, draining veins, central veins, arterial interventions and hand ischemia. World experts in the disciplines of interventional nephrology, interventional radiology and surgery offer creative visions of their practice and provide insights on topics from routine access creation to advanced novel techniques. Dialysis Access Cases presents solutions to problems encountered in practice while capturing the art of this medical discipline and challenging procedure.

In all branches of medicine, effective communication between health care professionals and patients, families and carers is essential to ensure first-class treatment. Increasing public awareness of health issues and the ready availability of health information have lead the public to be more widely informed about common conditions and the treatments available. Patients therefore attend a medical consultation better informed so the need for improved communication skills is even greater. This book aims to demystify the 'doctor-patient' relationship in order that patients and potential patients can more easily understand the information which doctors are seeking to convey as well as gaining some insight into the difficulties of communication from a doctor's perspective. Some conversations require specialised skills. Talking to people with difficult personalities and poor social skills can be challenging. Strong emotions of anger, frustration or distress need sensitive handling and particular age groups call on styles of address appropriate to their particular needs. Using the expertise of experienced doctors from many specialties this book covers not only the theory behind good communication skills but also gives a wealth of practical advice. The book covers ethical and legal issues, planning difficult conversations, the patient's and doctor's perspectives, issues surrounding special groups such as children and the elderly, and conversations with patients from different cultural backgrounds. Outlines of possible clinical cases posing specific problems are included with guidance on how to handle them.

Renal genetic disorders may become apparent at any time in life and recognition of specific renal disorders is important in allowing accurate genetic counselling. Active counselling requires knowledge about the natural history of the disorder, an understanding of the genetic component and mode of inheritance, risk of the disorder in other family members, information about patient attitudes towards family planning and the possibility of pre-natal diagnosis.

Genetics of Renal Disease provides a comprehensive account of both the hereditary nephropathies and more generalised disorders which may affect the renal tract. It includes comprehensive guidelines from an international group of authors on renal function and development, chromosomal disorders, dysmorphic syndromes, inherited predisposition to kidney cancer and gene therapy for renal cancer. Specific chapters deal with individual renal tract disorders such as an extensive discussion of Alport's disease, cystic renal diseases, the Bardet-Biedl and Alstrom syndromes. Each section gives a brief description of the clinical and pathological features of a particular disorder, followed by a review of the genetics of the disorder including incidence, inheritance of familial occurrence, genetic linkage and gene assignment, and prenatal diagnosis and carrier detection. Original studies are extensively quoted and are referenced at the end of each section. There are a great many dysmorphic syndromes which involve the urinary tract. These are incorporated within the book.

Aimed primarily at clinical and medical geneticists, this book will also appeal to researchers into genetic kidney disease and genetic counsellors as well as nephrologists with an interest in this area.

This book provides comprehensive, cutting-edge scientific data on acute and chronic tubulointerstitial nephritis, an area that has not been fully addressed in many nephrology textbooks. This book covers all relevant aspects of the disease, from historical aspects and pathogenesis to diagnosis, pathological findings, treatment, and prognosis and outcomes. The chapters also discuss both immune and non-immune mediated forms of the disease, as well as entities causing tubulointerstitial disease such as medications and toxins, infectious agents, autoimmune diseases, transplant rejection, genetic diseases, infiltrative disease and chronic kidney disease of unknown etiology. The text features up-to-date educational materials that will benefit both basic and clinical scientists. Written by experts in the field, Tubulointerstitial Nephritis is a valuable resource for clinicians, practitioners, researchers and trainees working in the field of nephrology and internal medicine.

This book provides a concise yet comprehensive resource on Diabetic Kidney Disease. Similar to the previous edition, the book reviews the most up-to-date research on diabetic nephropathy, the current understanding of its pathophysiology, renal structural alterations and clinical features, and summarizes recent evidence-based clinical treatment modalities for the prevention and management of diabetic kidney disease. General clinical aspects are also covered, as well as an overview to the novel approaches being designed by leading researchers in the field. A convenient compendium for physicians involved in the care of diabetic patients with varying degrees of kidney involvement, Diabetes and Kidney Disease, 2e is also a handy resource for medical residents and students interested in the current status and future approaches to reducing the burden of diabetes and diabetic kidney disease.

Das Standardwerk zur arteriellen Hypertonie, das keine noch so knifflige Frage auslasst! Die Klinik aller Hypertonieformen, die zeitgemasse Diagnostik und alle etablierten und neuen Therapieansatze sind von den jeweiligen Top-Spezialisten beschrieben. Ein besonderer Schwerpunkt liegt auf dem Umgang mit speziellen therapeutischen Problemen. Kein Arzt in Praxis und Klinik, der Patienten mit arterieller Hypertonie betreut, kann auf dieses Buch verzichten. Von der Hochdruckliga wird das Buch empfohlen.

This book describes the current status of vascular access for patients with end-stage renal failure who require dialysis. The book highlights controversial areas and problems and describes differences in practice in USA and Europe. Vascular Access is the Achilles heel of dialysis. In the United States and Europe in 1999 there were in access of 400,000 patients maintained on dialysis. The success of this life sustaining procedure is dependant on being able to successfully access the circulation and obtain blood flows of between two and five hundred mls per minute three times a week. In 1964 Cimino and Brescia described what remains today the premier form of vascular access. Not long after the development of the Cimino Brescia fistula it became apparent that there were patients in whom it was either impossible or extremely difficult to create an adequate fistula for dialysis. As dialysis technology has been applied to older and sicker patients this trend has continued, such that in the United States the majority of patients starting dialysis do not have a primary fistula. The maintenance of long-term vascular access in patients who do not have a primary fistula requires considerably increased effort. In recent years a number of innovations have considerably increased the success of long- term vascular access in these patients. This book brings together these developments, including strategies to prospectively detect impending vascular access failure, and strategies to pre-emptively prevent graft failure. Simultaneously with these developments there have been dramatic improvements in our understanding of the pathophysiology of graft failure, this improved understanding of the biology of access failure are beginning to bring to the clinical arena newer strategies to delay graft failure.

The Renal System at a Glance is a highly illustrated and practical guide to the structure and function of the kidney, renal, and urinary system. It also covers related disorders and abnormalities and their treatment. Fully updated to reflect the many exciting new developments in the understanding of nephrology, this new edition has been restructured to better integrate basic science and clinical examples to the medical school curricula. New chapters on glomerular filtration and global kidney medicine are included, while the latest guidance and approaches to acute kidney injury, chronic kidney diseases, and renal replacement therapy have also been incorporated. The Renal System at a Glance: * Offers clear explanations on tricky topics such as electrolytes, fluid balance and acid-base handling * Features new sections on glomerular filtration, and a new chapter on the global differences in kidney problems * Includes cross-referencing between basic science and related clinical content * Focuses on clinical disorders and investigations ideal for those embarking on medicine rotations * Illustrates each topic in a double page spread, complete with charts, graphs, and photographs * An updated companion website is available at www.ataglanceseries.com/renalsystem featuring animations and MCQs This new edition is the perfect guide for medical students, junior doctors, and allied health professionals, including specialist nurses, who wish to learn, or refresh their knowledge, on the kidney and renal system in health and disease.

Der arterielle Bluthochdruck ist die haufigste Form der Druckbelastung des linken Ventrikels. Der Hochdruck selbst gilt als einer der wichtigsten Risikofaktoren der koronaren Herzkrankheit. In dieser 3. Neuauflage werden erstmals systematische Untersuchungen zur Hypertrophieregression des Ventrikelmyokards sowie zur Beeinflussung der hypertensiven Mikroangiopathie dargestellt. Daruber hinaus analysiert der Autor die Probleme der Inzidenz von Herzrhythmusstorungen bei hypertensiver Herzhypertrophie, der diastolischen Eigenschaften des linken Ventrikels, der stummen Myokardischamie sowie der Rheologie des Koronarkreislaufs. Die Neuauflage berucksichtigt die Umsetzung der neuesten wissenschaftlichen Erkenntnisse in der Therapie des Hochdruckherzens."

Dieses Buch von H. Bartels, dem Begrunder der Urosonographie in Deutschland, ist ein Buch aus der Praxis fur die Praxis. Es ist dem sonographierenden Arzt eine unmittelbare Hilfe fur die taglich zu treffenden Entscheidungen bei der Klarung morphologischer Veranderungen der Niere und ihrer Umgebung. Besonders hingewiesen wird auf die umfassende Differentialdiagnostik aller Raumforderungen der Niere mit pragmatischen Merksatzen zur schnellen Interpretation. Der Schwerpunkt liegt hierbei auf der Fruherkennung von Tumoren und ihrer Differentialdiagnostik."

Im vorliegenden Buch werden s{mtliche Aspekte immunologischer Behandlungsverfahren bei urologischen Karzinomerkrankungen dargestellt. Au erdem wird auf die theoretischen und wissenschaftlichen Grundlagen der Immuntherapie dieser Erkrankungen eingegangen. Die Autoren geben eine umfassende ]bersicht }ber den derzeitigen Stand der Forschung auf diesem Gebiet und pr{sentieren aktuelle immunologische Therapieschemata urologischer Tumoren.

Dieses Buch beschreibt die Bedeutung des Kallikrein-Kinin-Systems fur die Nierenfunktion und die Kreislaufregulation und diskutiert die Rolle seiner Regulationsmechanismen. Im 1. Teil des Buches werden die aktuellsten, hochspezifischen Messverfahren vorgestellt, die als Grundlage fur die Tierversuche und die Studien an Probanden und Patienten verwendet wurden. Erstmalig steht damit eine zuverlassige Bestimmung der einzelnen Komponenten dieses Systems zur Verfugung. Der 2. Teil des Buches befasst sich mit der physiologischen Bedeutung des renalen Kallikrein-Kinin-Systems fur die Nierenfunktion und die Kreislaufregulation, wahrend im 3. Teil renale und plasmatische Veranderungen im Kallikrein-Kinin-System an dem wohl bisher grossten Patientenkollektiv mit arterieller Hypertonie berichtet wird. Dieses Buch ist fur die klinische und wissenschaftliche Arbeit aller Forscher, die sich mit diesem Thema beschaftigen, ein ausgezeichnetes Nachschlagewerk.

In recent years, important technological innovations have made it possible to evaluate the small bowel endoscopically. Thus, traditional diagnostic methods such as imaging techniques are flanked by enteroscopy. The aim of this book is to present the results of enteroscopy as a method to diagnose small bowel disease, correlating it to the other investigative methods and above all to clinical findings. The book is a unique selected collection of images deriving from the results of documented experience and also including a brief clinical presentation, tables and diagrams of diagnostic algorithms. Renowned and accredited experts in gastroenterology, enteroscopy and researchers in the sector of small bowel disease have contributed to this volume.

Das Buch gibt eine aktuelle Darstellung der Behandlungsmethoden des Nierenkarzinoms. Neben der Wertigkeit der heutigen bildgebenden Verfahren und der Pathologie des Nierenkarzinoms werden die operativen Techniken und deren Ergebnisse ausfuhrlich dargestellt, insbesondere die organerhaltende Nierentumorchirurgie (Nierentumorausschalung, Exzisionen, die operative Ausraumung von Nierentumoren mit Cavazapfen und die systematische radikale Lymphadenektomie bei Tumornephrektomie). Weitere Themen befassen sich mit dem Stellenwert der Embolisation in der Behandlung des Nierenkarzinoms, immunologischen Aspekten sowie der Strahlentherapie und der Chemotherapie des metastasierten Nierenkarzinoms. Die umfassende Darstellung des Themas macht dieses Buch zu einem zuverlassigen Ratgeber fur alle, die Patienten mit Nierenkarzinom behandeln."

Im vorliegenden Band wird die vielschichtige klinische Problematik von Herzmuskel- und Perikarderkrankungen sowie der Herz- und Perikardtumoren ausfuhrlich dargestellt. Die Klassifizierung der Myokarderkrankungen folgt der derzeitigen Einteilung in (primare) Kardiomyopathien und (sekundare) spezifische Herzmuskelerkrankungen. Besondere Schwerpunkte liegen in der Darstellung der Immunpathogenese myokardialer Erkrankungen und der Anwendung neuer diagnostischer Verfahren wie Myokardbiopsie und bildgebender Verfahren. Breiter Raum ist in der Therapie neben den klassischen Methoden der Anwendung von Vasodilatantien, Betablockern, Kalziumantagonisten und Immunsuppressiva gewidmet. Erstmalig werden Myokardalterationen bei genetischen Erkrankungen und neurologischen Systemkrankheiten zusammenfassend dargestellt. Von besonderer Aktualitat sind toxische Einwirkungen auf das Myokard sowie Strahlenschaden. Internisten und allen kardiologisch interessierten Arzten vermittelt dieser Band umfassende Basisinformationen uber die diagnostischen und therapeutischen Fortschritte unter Einschluss der jeweils aktuellen Probleme in Pathogenese und Therapie."

Many inherited diseases and non-herediatry disorders have in common the development of renal cyctic disease. The most common, autosonal dominant polycystic kidney disease, is responsible for 5-10% of end-stage renal failure treated by dialysis or transplantation.
Since the publication six years ago of the last book on polycystic kidney disease, a number of genes causing the disease have been identified, mapped, or sequenced; new experimental models and the application of molecular biology techniques have provided new insights into the pathogenesis of polycystic kidney disease; novel clinical studies have provided valuable information for the prevention, evaluation, and treatment of the complications of this disease. This book provides an updated, state-of-the-art review of the genetics, pathophysiology, evaluation, and management of these diseases and will be of interest to both basic researchers and clinicians in nephrology.

Das Buch behandelt alle Aspekte des Purinstoffwechsels sowie den Purimidinstoffwechsel. Die klinischen Abschnitte werden durch Kapitel zu denbiochemischen Grundlagen er- g{nzt. Neben der Terapie von St-rungen des Purinstoffwech- sels wird auch die Bedeutung der Purinanaloga in der medika- ment-sen Therapie diskutiert, wo sie z.B. zur Behandlung der HIV-Infektion eingesetzt werden. Das Buch ist deshalb sowohl f}r denklinisch t{tigen Arzt als auch f}r den Wis- senschaftler interessant.

- Primare und sekundare VUR sind zu differenzieren, sekundare VUR mtissen kausaI be- handelt werden; flir sie gelten die folgenden Oberlegungen nicht. - Wenn auch ein Einzelbefund fur die Wahl der Therapieform nie entscheidend sein darf, so hat sich die radiologische Graduierung nach Heikel u. Parkulainen (1966) in die Grade I-V (Abb. 11-16) doch aIs bedeutsam fur die Prognose erwiesen. Die Stadien I und II soIl ten konservativ behandelt werden, wenn keine Golflochostien vorliegen. Bei konservativer Behandlung ist die niedrig dosierte dauernde der intermittierenden antibiotischen Behandlung deutlich tiberlegen. Unter niedrig dosierter antibiotischer Dauertherapie ist in den Stadien I und II nur sel- ten mit einer Verschlechterung zu rechnen. Bisher sind nennenswerte, ernsthafte Nebenwirkungen der niedrig dosierten antibioti- schen Dauertherapie nicht zu erwarten. Bei zusatzlichei, auch geringgradiger Harnrohrenenge soUte bei VUR der Grade I-III immer die moglichst frtihe Beseitigung des distalen Abflu hindernisses vorgenommen werden (vgl. nachfolgendes Kapitel und Tab. 7 und 8). Operieren sollte man vor Vollendung des 3. Lebensjahres nur bei vitaler Indikation. Da andererseits nach dem ersten Lebensjahr kein signiflkanter Unterschied in der Hei- lungsrate bezogen auf die Altersgruppen besteht, sollten VUR der Grade IV und V moglichst frtih durch ARP bzw. Nephroureterektomie versorgt werden (vgl. 10.4. Ope- rative Therapie). Paraureterale Divertikel sind eine Kontraindikation zur konservativen Therapie. 10.4. Operative Therapie Vor dem umfangreichen Tell tiber die Antirefluxplastiken (ARP) wird zuniichst besprochen, wann eine ARP noch nicht (distaIes Abflu hindernis) oder nicht mehr (Nephroureter- ektomie) sinnvoll ist.

Dieses Standard-Praxisbuch fur das ganze Transplantations-team bietet einen umfassenden Uberblick uber den aktuellen Leistungsstand im Bereich der Nierentransplantation: Neben den wesentlichen Grundlagen werden alle Aspekte der Nierenverpflanzung dargestellt, die wahrend der pra-, peri- und postoperativen Phasen relevant sind.
Concise text: Dieses Standard-Praxisbuch fur das ganze Transplantations-team bietet einen umfassenden Uberblick uber den aktuellen Leistungsstand im Bereich der Nierentransplantation.
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In diesem Buch wird eine neue diagnostische Methode vorgestellt: das ambulante Blutdruckmonitoring (ABDM). Die Langzeitblutdruckmessung und vor allem das ABDM haben einen Wissenszuwachs in der Hypertonologie erbracht, der wesentlich zur Erkennung des Bluthochdruckleidens beitr{gt. Eine fr}he Diagnose und die daraus resultierende Behandlung der arteriellen Hypertonie sind von entscheidender pr{ventiver Bedeutung. Die hier klar erl{uterte Rolle des ABDM in der allgemeinen Hypertonologie und die anschaulichen Beispiele spezieller Anwendungsm-glichkeiten bezeugen den Wert dieser Untersuchungsmethode f}r die Therapie des Bluthochdruckleidens.