An accessible introduction to the history, fundamental concepts, challenges, and controversies of the fMRI by one of the pioneers in the field. The discovery of functional MRI (fMRI) methodology in 1991 was a breakthrough in neuroscience research. This non-invasive, relatively high-speed, and high sensitivity method of mapping human brain activity enabled observation of subtle localized changes in blood flow associated with brain activity. Thousands of scientists around the world have not only embraced fMRI as a new and powerful method that complemented their ongoing studies but have also gone on to redirect their research around this revolutionary technique. This volume in the MIT Press Essential Knowledge series offers an accessible introduction to the history, fundamental concepts, challenges, and controversies of fMRI, written by one of the pioneers in the field. Peter Bandettini covers the essentials of fMRI, providing insight and perspective from his nearly three decades of research. He describes other brain imaging and assessment methods; the sources of fMRI contrasts; the basic methodology, from hardware to pulse sequences; brain activation experiment design strategies; and data and image processing. A unique, standalone chapter addresses major controversies in the field, outlining twenty-six challenges that have helped shape fMRI research. Finally, Bandettini lays out the four essential pillars of fMRI: technology, methodology, interpretation, and applications. The book can serve as a guide for the curious nonexpert and a reference for both veteran and novice fMRI scientists.

Modern neuroimaging offers tremendous opportunities for gaining insights into normative development and a wide array of developmental neuropsychiatric disorders. Focusing on ontogeny, this text covers basic processes involved in both healthy and atypical maturation, and also addresses the range of neuroimaging techniques most widely used for studying children. This book will enable you to understand normative structural and functional brain maturation and the mechanisms underlying basic developmental processes; become familiar with current knowledge and hypotheses concerning the neural bases of developmental neuropsychiatric disorders; and learn about neuroimaging techniques, including their unique strengths and limitations. Coverage includes normal developmental processes, atypical processing in developmental neuropsychiatric disorders, ethical issues, neuroimaging techniques and their integration with psychopharmacologic and molecular genetic research approaches, and future directions. This comprehensive volume is an essential resource for neurologists, neuropsychologists, psychiatrists, pediatricians, and radiologists concerned with normal development and developmental neuropsychiatric disorders.

Imaging tests are integral to the management of patients with suspected lung disease. Staggering advances in radiological technology have been associated with an ever-increasing complexity, and so keeping up with terminology, understanding the significance of basic radiological signs, and appreciating the prognostic impact of findings on imaging tests, is not an easy undertaking for the physician. Until now, there has been a lack of practical, pocket-sized, but authoritative texts dealing principally with the imaging features of pulmonary disease. Covering the essential elements of pulmonary imaging in a concise and digestible format, Thoracic Imaging deals with both the key principles of thoracic imaging, including a separate section on the common radiological terms used to describe pulmonary pathology, and the principal pathological compartments that are affected in specific disease processes. It is packed with over 600 high quality illustrations to highlight the important radiological features in the different diseases, with an emphasis on chest radiography (CXR) and computed tomography (CT) to mirror routine clinical practice.

This fully updated, self-contained textbook covering modern optical microscopy equips students with a solid understanding of the theory underlying a range of advanced techniques. Two new chapters cover pump-probe techniques, and imaging in scattering media, and additional material throughout covers light-sheet microscopy, image scanning microscopy, and much more. An array of practical techniques are discussed, from classical phase contrast and confocal microscopy, to holographic, structured illumination, multi-photon, and coherent Raman microscopy, and optical coherence tomography. Fundamental topics are also covered, including Fourier optics, partial coherence, 3D imaging theory, statistical optics, and the physics of scattering and fluorescence. With a wealth of end-of-chapter problems, and a solutions manual for instructors available online, this is an invaluable book for electrical engineering, biomedical engineering, and physics students taking graduate courses on optical microscopy, as well as advanced undergraduates, professionals, and researchers looking for an accessible introduction to the field.

This book addresses all the issues a patient may experience prior to receiving a VAD. Selection of equipment, practical aspects of technique, the pros and cons of the various veins, and modifications of technique for certain circumstances are examined. Covereage also includes the roles played by radiologists, anaesthetists, surgeons, nurses, and other team memebers. Throughout the chapters a reference is made to the IV Therapy Standards published by the Royal College of Nursing IV Therapy Forum in 2003. Each chapter is evidence based and fully referenced.

This book covers the broad field of cellular, molecular, preclinical, and clinical imaging either associated with or combined with photodynamic therapy (PDT). It showcases how this approach is used clinically for cancer, infections, and diseases characterized by unwanted tissue such as atherosclerosis or blindness. Because the photosensitizers are also fluorescent, the book also addresses various imaging systems such as confocal microscopy and small animal imaging systems, and highlights how they have been used to follow and optimize treatment, and to answer important mechanistic questions. Chapters also discuss how imaging has made important contributions to clinical outcomes in skin, bladder, and brain cancers, as well as in the development of theranostic agents for detection and treatment of disease. This book provides a resource for physicians and research scientists in cell biology, microscopy, optics, molecular imaging, oncology, and drug discovery.

Part of the "What Do I Do Now?: Emergency Medicine" series, Pediatric Emergency Radiology uses a case-based approach to cover common and important topics in radiology imaging for pediatric emergency care. Each chapter provides a discussion of the diagnosis, key points to remember, and selected references for further reading. Areas of controversy are clearly delineated with a discussion regarding evidence-based options and a balanced view of treatment and disposition decisions. The book addresses a wide range of topics including neonatal respiratory distress, foreign body ingestion, Bronchiolitis, and related radiology issues faced by emergency medicine providers and pediatricians. Pediatric Emergency Radiology is an engaging collection of thought-provoking cases which clinicians can utilize for effective imaging of pediatric patients. The volume is also a self-assessment tool that tests the reader's ability to answer the question, "What do I do now?"

This book is an introduction to diagnostic radiology (including nuclear medicine). Written in a user-friendly format, it takes into account that radiology is divided into many subspecialties that constitute a universe of their own. The book is subdivided into ten sections, such as musculoskeletal, thoracic, gastrointestinal, cardiovascular and breast imaging. Each chapter is presented with an introduction of the subspecialty and ten case studies with illustrations and comments from anatomical, physiopathological and radiological standpoints and with bibliographic recommendations. This book is aimed at radiologists, radiology residents, medical students, nurses, technicians, and anybody else beginning to work in the radiological Written for: Medical students, residents of radiology, nurses, technicians

Part of the Oxford Textbooks in Clinical Neurology series, the Oxford Textbook of Neuroimaging provides an overview of the established and latest neuroimaging methodologies, and illustrates their application to the main diseases of the brain and the spinal cord including movement disorders, headache and stroke. In addition, assessments of neuroimaging techniques in both adult and paediatric neurological conditions are included, enabling thorough examples from both age groups. This full-colour book contains 280 detailed photographs and illustrations that enable a clear understanding of each technique. Covering the newest advances, each different imagining technique is comprehensively described, providing a practical relevance and a stimulus for more in-depth readings. The print edition is supplemented with a concurrent online edition, which allows access to the full content of the textbook, contains links from the references to primary research journal articles, and provides access to figures and tables that can be downloaded by the user. Providing a balanced state-of-the-art guide to neuroimaging for neurologists and radiologists, this title will enhance understanding of the pathophysiological basis of neurological conditions and will help set the stage for future research.

This easy-to-follow textbook presents an engaging introduction to the fascinating world of medical image analysis. Avoiding an overly mathematical treatment, the text focuses on intuitive explanations, illustrating the key algorithms and concepts in a way which will make sense to students from a broad range of different backgrounds. Topics and features: explains what light is, and how it can be captured by a camera and converted into an image, as well as how images can be compressed and stored; describes basic image manipulation methods for understanding and improving image quality, and a useful segmentation algorithm; reviews the basic image processing methods for segmenting or enhancing certain features in an image, with a focus on morphology methods for binary images; examines how to detect, describe, and recognize objects in an image, and how the nature of color can be used for segmenting objects; introduces a statistical method to determine what class of object the pixels in an image represent; describes how to change the geometry within an image, how to align two images so that they are as similar as possible, and how to detect lines and paths in images; provides further exercises and other supplementary material at an associated website. This concise and accessible textbook will be invaluable to undergraduate students of computer science, engineering, medicine, and any multi-disciplinary courses that combine topics on health with data science. Medical practitioners working with medical imaging devices will also appreciate this easy-to-understand explanation of the technology.

"Introduction to Sectional Anatomy Workbook and Board Review Guide "helps you better understand the principles of sectional anatomy, When used in conjunction with its corresponding text, this workbook reinforces key concepts covered in "Introduction to Sectional Anatomy "and contains a variety of exercises and tools that make it easy for you to remember essential information and build critical-thinking skills. This resource is also designed to thoroughly prepare you for the CT and MR registry examinations.

The fourth edition of this highly successful textbook discusses the practical applications of the various methods of regional anaesthesia, including ultrasound, as well as giving an account of their theoretical aspects. The well-established author team use their experience to provide a practical and stimulating book which reflects everyday clinical activity, supplemented by high definition ultrasound images and schematic diagrams. The book will also discuss the place of regional anaesthesia in current medical practice, particularly with regard to pain processes, ultrasound imaging, and patient outcomes. Regional anaesthesia is a rapidly expanding sub-speciality of anaesthesia: routine provision of long-lasting pain relief and the introduction of real-time ultrasound block has fuelled a demand for cadaver and ultrasound-based anatomy training courses. Thus, it is more important than ever to have a thorough grounding in this exciting subspecialty.

This book constitutes the refereed proceedings of the 5th International Workshop and Challenge on Computational Methods and Clinical Applications for Spine Imaging, CSI 2018, held in conjunction with MICCAI 2018, in Granada, Spain, in September 2018. The 8 full papers presented together with 8 short papers and 1 keynote were carefully reviewed and selected for inclusion in this volume. Papers on novel methodology and clinical research, and also papers which demonstrate the performance of methods on the provided challenges, the aim is to cover both theoretical and very practical aspects of computerized spinal imaging.

This two-volume set LNCS 11383 and 11384 constitutes revised selected papers from the 4th International MICCAI Brainlesion Workshop, BrainLes 2018, as well as the International Multimodal Brain Tumor Segmentation, BraTS, Ischemic Stroke Lesion Segmentation, ISLES, MR Brain Image Segmentation, MRBrainS18, Computational Precision Medicine, CPM, and Stroke Workshop on Imaging and Treatment Challenges, SWITCH, which were held jointly at the Medical Image Computing for Computer Assisted Intervention Conference, MICCAI, in Granada, Spain, in September 2018. The 92 papers presented in this volume were carefully reviewed and selected from 95 submissions. They were organized in topical sections named: brain lesion image analysis; brain tumor image segmentation; ischemic stroke lesion image segmentation; grand challenge on MR brain segmentation; computational precision medicine; stroke workshop on imaging and treatment challenges.

Pattern recognition is an important learning tool in the interpretation of ECGs. Unfortunately, until faced with a patient with an arrhythmia or structural heart disease, pediatric practitioners generally receive limited exposure to ECGs. The ability to clearly distinguish an abnormal ECG pattern from a normal variant in an emergency situation is an essential skill, but one that many pediatricians feel ill-prepared to utilize confidently. In "Pediatric ECG Interpretation: An Illustrative Guide," Drs. Deal, Johnsrude and Buck aim to address this issue by illustrating many of the ECG patterns a pediatric practitioner is likely to encounter.

ECG illustrations with interpretations are presented in several categories: normal children of all ages, acquired abnormalities such as hypertrophy or electrolyte disorders, and common congenital heart disease lesions. Later sections cover bradycardia, supraventricular and ventricular arrhythmias, and a basic section on pacemaker ECGs. Simple techniques used to interpret mechanisms of arrhythmias are described as a resource for practitioners in cardiology, adult electrophysiology, or pediatrics who may not have a readily accessible resource for these ECG examples.

The accompanying CD has been prepared with 3 purposes in mind:
1 as a self-evaluation tool for interpretation of ECGs
2 as a teaching reference for Cardiology fellows, residents, and house staff
3 as an invaluable resource for the Emergency Room physician or pediatrician who might obtain an ECG on a pediatric patient

Written by a pioneer in the field, this text provides a complete introduction to X-ray microscopy, providing all of the technical background required to use, understand and even develop X-ray microscopes. Starting from the basics of X-ray physics and focusing optics, it goes on to cover imaging theory, tomography, chemical and elemental analysis, lensless imaging, computational methods, instrumentation, radiation damage, and cryomicroscopy, and includes a survey of recent scientific applications. Designed as a 'one-stop' text, it provides a unified notation, and shows how computational methods in different areas are linked with one another. Including numerous derivations, and illustrated with dozens of examples throughout, this is an essential text for academics and practitioners across engineering, the physical sciences and the life sciences who use X-ray microscopy to analyze their specimens, as well as those taking courses in X-ray microscopy.

Practical and clinically oriented, the third edition of Clinical Molecular Anatomic Imaging focuses on PET/CT, SPECT/CT, and PET/MR examinations - precisely the information you need to know, without lengthy physics discussions. Ideal for clinical hybrid imaging users, it fully integrates all applications, allowing you to easily compare modalities and decide whether to use PET/CT, PET/MR, or SPECT/CT to solve a clinical dilemma. More than 1,600 high-quality illustrations document the use of integrated imaging and provide superb visual references for interpreting integrated imaging studies. Key Features Covers established and emerging indications for the three most versatile and powerful hybrid molecular anatomic imaging modalities currently in clinical use: PET/CT, SPECT/CT and PET/MR. Follows a practical, disease-based structure. The only available book that incorporates the emerging field of PET/MR in a systematic manner. More than 1,600 superb illustrations document the use of integrated imaging. A new section covers workflow and normal scans with various clinical tracers. Sharp focus on clinical applications, omitting technological and radiopharmaceutical details. Each chapter is self-contained and can be consulted for quick reference on its own. World-renowned clinician-scientist Gustav von Schulthess provides editorial leadership and a strong understanding of both nuclear medicine imaging and cross-sectional imaging. Now with the print edition, enjoy the bundled interactive eBook edition, which can be downloaded to your tablet and smartphone or accessed online and includes features like: Complete content with enhanced navigation Powerful search tools and smart navigation cross-links that pull results from content in the book, your notes, and even the web Cross-linked pages, references, and more for easy navigation Highlighting tool for easier reference of key content throughout the text Ability to take and share notes with friends and colleagues Quick reference tabbing to save your favorite content for future use

An introduction to Neuroimaging and Neurophysiology in Psychiatry, this book explains the basic physics and physiology behind the main techniques of neuroimaging, including MRI and PET, and non-invasive neurophysiology. This title covers all the clinically relevant aspects of neuroimaging and neurophysiology methods. It includes individual chapters on techniques, diagnostic disease markers, and neurophysiological treatments to ensure psychiatrists are familiar with the clinical relevance of reported abnormalities. With the latest research, Neuroimaging and Neurophysiology in Psychiatry is an invaluable and easy-to-read reference that will help practising psychiatrists in the evaluation of the use of neuroimaging methods in clinical, research, and forensic settings.

Multiple advanced neuroimaging applications in various neurodegenerative diseases including Parkinson's disease (PD), frontotemporal dementia (FTD), vascular dementia (VaD) and autism spectrum disorder (ASD) are covered in this book. Relatively novel techniques such as integrated PET/MRI and independent component analysis (ICA)-based dual regression (DR) methods were developed to capture multi-level molecular/functional and structural/microstructural as well as high-order inter-network coordination abnormalities. For instance, both PET dopamine transporter and striatal binding ratio reductions in the caudate and putamen were found in PD, consistent with the diffusion tensor imaging (DTI) fractional anisotropy (FA) reduction and fMRI voxel-mirrored homotopic correlation (VMHC) in the substantia nigra (swallow tail sign signature of PD). Furthermore, dopamine storage and pathway labeled with the vesicular monoamine transporter tracer identified decreased densities in the bilateral mesial temporal cortex, caudate, orbitofrontal cortex, left frontal and occipital cortices, consistent with the morphological atrophy, functional connectivity and conductivity deficits in PD. Similarly in FTD patients, the advanced MRI methods such as ICA-DR, VMHC, voxel-based morphometry (VBM) as well as PET tracer for amyloid accumulation and FDG glucose uptake identified typical brain atrophy, structural dis-connectivity, glucose hypometabolism, higher neuropathological burden, lower interhemispheric correlation as well as disrupted intra- and inter-network modulation in the orbitofrontal and anterior temporal cortices together with insular and frontoparietal networks, with the cerebellum and dorsolateral attentional network as typical compensations. Functional and structural abnormalities had further been elucidated in the VaD dependent participants and autistic children. For instance, both lower FA and VMHC, brain atrophy and functional connectivity deficits, demyelination, axonal degeneration and white matter integrity damage in several white matter tracts were present in the dependent compared to independent participants in VaD data cohort. Increased neuronal activity with higher global fractional amplitude of low frequency fluctuation (fALFF) in the conventional and slow-wave sub-band was confirmed with less efficiency of systematic integration in VaD dependent group. Moreover, in ASD compared to controls, regional gray matter volume and cortical thickness in all four brain lobes increased, whereas white matter volume were decreased in addition to the lower temporal, visual and superior frontal but higher inferior and dorsolateral prefrontal cortical functional connectivities exhibited in ASD. The differences in each type of disease could also be revealed with the same imaging method based on either unique region or distinct brain circuit inter-connection, using VMHC, ICA-DR, DTI, VBM, fALFF and graph-theory based small-worldness analysis. In this book, we have developed and generalized conventional and advanced imaging methodologies to several common neurodegenerative diseases. For instance, we have identified the unique imaging signature for each disease type and the underlying neuropathological mechanism connections with conductivity, structural and microstructural connectivity, intra- and inter-network correlation, systematic integration and efficiency analyses. Our objective, comprehensive and confirmative results indicated great potential in utilizing these quantifications for accurate disease classification and staging. With solid imaging evidence, thorough analysis and generalized applications, this book should capture the interests of readers in the broad fields of brain science, disease diagnosis and effective treatment.

Dieser Band behandelt das weite Gebiet der organisch bedingten psychischen Stoerungen. Einleitend werden die Grundlagen der psychoorganischen Syndromlehre, der Neuropsychologie, Neurophysiologie und Neuroradiologie abgehandelt. Der Hauptteil des Bandes beschreibt in mehreren Beitragen alle wichtigen Gruppen psychiatrischer Krankheiten, die organisch bedingt sind. Ein Bericht uber den gegenwartigen Stand der Schlafforschung beschliesst den Band. Insgesamt wird mit diesem Band ein zusammenfassender UEberblick uber ein Thema vermittelt, das trotz seiner grossen epidemiologischen Bedeutung seit langerer Zeit nicht mehr im Vordergrund des psychiatrischen Interesses gestanden hat.

This book presents the cutting-edge technologies of knee joint vibroarthrographic signal analysis for the screening and detection of knee joint injuries. It describes a number of effective computer-aided methods for analysis of the nonlinear and nonstationary biomedical signals generated by complex physiological mechanics. This book also introduces several popular machine learning and pattern recognition algorithms for biomedical signal classifications. The book is well-suited for all researchers looking to better understand knee joint biomechanics and the advanced technology for vibration arthrometry. Dr. Yunfeng Wu is an Associate Professor at the School of Information Science and Technology, Xiamen University, Xiamen, Fujian, China.

This book constitutes the refereed proceedings of the 6th International Workshop ABDI 2014, held in conjunction with MICCAI 2014, in Cambridge, MA, USA, in September 2014. The book includes 29 papers which were carefully reviewed and selected from 33 submissions. The topics covered are liver and pancreas - ablation, perfusion, and segmentation; gastrointestinal tract - Crohn's disease; gastrointestinal tract - colonoscopy, colonography; and abdominal operation planning - registration, segmentation.

Die Wirkung ionisierender Strahlen im Niedrigdosenbereich mit den moglichen Risiken von Spatschaden wird derzeit noch kontrovers diskutiert. Verschiedene Ansatze und Studien zu diesem Problemkreis wurden von Experten unterschiedlicher Fachrichtungen - der Strahlenbiologie, Nuklearmedizin und Physik - im Laufe des Symposiums vorgestellt. Die Diskussion betraf vor allem genetische Schaden, die sich auf Grund tierexperimenteller Daten belegen lassen sowie Untersuchungen zu kanzerogenen und teratogenen Effekten von Niedrigstdosisstrahlen, vor allem durch naturliche Grundstrahlung oder durch Exponierung in der Strahlenmedizin. Von besonderem Interesse sind die Ergebnisse der Neubewertung des Strahlenkrebsrisikos von Uberlebenden der Atombombenexplosionen in Japan. Messungen und Beurteilungen der Gesundheitsrisiken im Zusammenhang mit der Reaktorkatastrophe von Tschernobyl bilden die Grundlage fur weitere Diskussionen uber Gefahren und Nutzen der Kernenergie.

Die M|glichkeiten der angiographischen Diagnostik und der radiologischen Interventionen bei degenerativen Gef{~erkrankungen sind in diesem Buch aktuell und }bersichtlich zusammengefa~t. F}r alle wichtigen Indikationsbereiche der Angiographie werden die Fragestellungen, die Vor- und Nachteile der ven|sen und arteriellen Vorgehensweise und die Aussagekraft der Verfahren diskutiert. Technik, Indikationen, Ergebnisse und Kemplikationen von Angioplastie, Stentimplantationen, Fibrinolyse und Sympathikolyse werden systematisch dargestellt. Angiologisch t{tige [rzte erhalten damit einen kompakten ]berblick }ber die derzeitigen diagnostischen und therapeutischen Verfahren.