Biomedical image analysis has become a major aspect of engineering sciences, and radiology in particular has become a dominant player in the field. Recent developments have made it possible to use biomedical imaging to view the human body from an anatomical or physiological perspective in a non-invasive fashion. Computer-aided diagnosis consists of developing algorithms and intelligent software components that can automatically process images and spot potential irregularities in the health chain.

The aim of this book is to explain the process of biomedical imaging, from image acquisition to automated diagnosis. This process consists of three thematic areas. The first is dedicated to the acquisition process and the underlying properties of images from a physics-oriented perspective. The second part addresses the dominant state-of-the-art methodologies behind content extraction and interpretation of medical images. The third section presents an application-based example, which develops solutions to address the particular needs of various diagnoses.

This complete volume is an exceptional tool for radiologists, research scientists, senior undergraduate and graduate students in health sciences and engineering, and university professors. This book offers a unique guide to the entire chain of biomedical imaging, explaining how image formation is done, and how the most appropriate algorithms are used to address demands and diagnoses.

The Atlas of Genitourinary Oncological Imaging presents a comprehensive visual review of appearances for normal anatomy and oncological diseases in the genitourinary system using over 900 radiological images and illustrations. The book presents current imaging techniques and discusses the role of imaging in pre-treatment staging and post-treatment follow-up. Diseases discussed include kidney, adrenal gland, upper tract, bladder, prostate, testes, and pediatric malignancies. Individual chapters include normal anatomy, imaging techniques, and pathology of each cancer type. The staging of the malignancy and what to include in the radiology report are discussed, and expected and complicated postoperative and post-treatment findings and recurrence are presented. Dedicated chapters on interventional and radiation therapy discuss their unique role in the management and treatment of oncology of the genitourinary system. Additionally, a chapter on chemotherapy toxicities discusses drug reaction treatment therapies unique to the genitourinary system. Edited and written by radiologists from the genitourinary disease management team at Memorial Sloan-Kettering Cancer Center, the Atlas of Genitourinary Oncological Imaging is an ideal resource for radiology and urology trainees seeking a review of the basics and for practicing radiologists looking for answers to challenging cases confronted in daily practice.

Neutron capture therapy (NCT) is based on the ability of the non-radioactive isotope boron-10 to capture thermal neutrons with very high probability and immediately to release heavy particles with a path length of one cell diameter, which in principle allows for tumor cell-selective high-LET particle radiotherapy. This book provides a comprehensive summary of the progress made in NCT in recent years. Individual sections cover all important aspects, including neutron sources, boron chemistry, drugs for NCT, dosimetry, and radiation biology. The use of NCT in a variety of malignancies and also some non-malignant diseases is extensively discussed. NCT is clearly shown to be a promising modality at the threshold of wider clinical application. All of the chapters are written by experienced specialists in language that will be readily understood by all participating disciplines.

Atlas of Brain and Spine Oncology Imaging presents a comprehensive visual review of pathologic disease variations of cancers of the brain and spine through extensive radiologic images. The focus of the book is on algorithmic strategies for identifying neoplastic pathologies commonly found in brain and spinal tumors through a visual representation of the variety of appearances that each neoplasm takes, within both benign and malignant manifestations. With contributions from radiologists on staff at a National Cancer Institute-designated comprehensive cancer center, who draw from an extensive collection of diagnostic images across all imaging modalities, this book will be valuable to practicing radiologists, radiation oncologists, surgeons and other practitioners involved in the diagnosis and treatment of brain and spinal neoplasms in all patient populations.

Traditional research methodologies in the human respiratory system have always been challenging due to their invasive nature. Recent advances in medical imaging and computational fluid dynamics (CFD) have accelerated this research. This book compiles and details recent advances in the modelling of the respiratory system for researchers, engineers, scientists, and health practitioners. It breaks down the complexities of this field and provides both students and scientists with an introduction and starting point to the physiology of the respiratory system, fluid dynamics and advanced CFD modeling tools. In addition to a brief introduction to the physics of the respiratory system and an overview of computational methods, the book contains best-practice guidelines for establishing high-quality computational models and simulations. Inspiration for new simulations can be gained through innovative case studies as well as hands-on practice using pre-made computational code. Last but not least, students and researchers are presented the latest biomedical research activities, and the computational visualizations will enhance their understanding of physiological functions of the respiratory system.

This book is instrumental to building a bridge between scientists and clinicians in the field of spine imaging by introducing state-of-the-art computational methods in the context of clinical applications. Spine imaging via computed tomography, magnetic resonance imaging, and other radiologic imaging modalities, is essential for noninvasively visualizing and assessing spinal pathology. Computational methods support and enhance the physician's ability to utilize these imaging techniques for diagnosis, non-invasive treatment, and intervention in clinical practice. Chapters cover a broad range of topics encompassing radiological imaging modalities, clinical imaging applications for common spine diseases, image processing, computer-aided diagnosis, quantitative analysis, data reconstruction and visualization, statistical modeling, image-guided spine intervention, and robotic surgery. This volume serves a broad audience as contributions were written by both clinicians and researchers, which reflects the intended readership as well, being a potentially comprehensive book for all spine related clinicians, technicians, scientists, and graduate students.

A single source of information about pathologic lesions of the adrenal, the urinary tract, and the male genital system, minimizing the need to consult numerous texts of limited scope, this book contains gross photos and photomicrographs of virtually every pathologic entity, and variants of those entities. The book is lavishly illustrated with images accompanied by text that explains the visual images, highlighting key diagnostic features and providing brief but helpful discussions of the differential diagnosis. This book is designed for practicing pathologists and pathologists in training as well as urologists, GU radiologists, GU radiation oncologists, and GU medical oncologists.

Modern signal and image acquisition systems used in the field of cardiology acquire, analyze, and store data digitally. Surface electrocardiography, intra-cardiac electrogram recording, echocardiograms, x-ray, magnetic resonance imaging, and computed tomography are among the modalities in the cardiology field where signal processing is applied. Digital signal processing techniques allow us to automate many of the analyses that had previously been done manually with greater precision, accuracy and speed, as well as detect features and patterns in data that may be too subtle to observe by eye. As more cardiologists are becoming more reliant on such technology, a basic understanding of digital signals and the techniques used to extract information from these signals are required.

This book provides a comprehensive up-to-date review of optical approaches used in brain imaging and therapy. It covers a variety of imaging approaches including diffuse optical imaging, laser speckle imaging, photoacoustic imaging and optical coherence tomography. A number of laser-based therapeutic techniques are reviewed, including photodynamic therapy, fluorescence guided resection and photothermal therapy. Fundamental principles and instrumentation are discussed for each imaging and therapeutic approach.

This Recent Results in Cancer Research volume contains the majority of the invited expert contributions from the First St. Gallen EORTC Gastrointestinal Cancer Conference, held on 22-24 March 2012 in St. Gallen, Switzerland. Written by some of the world's leading experts in the field, the volume constitutes a comprehensive update on recent developments in the imaging, molecular biology, pathology, and multidisciplinary management of early cancer of the gastrointestinal tract. The latest recommendations regarding diagnosis and treatment are provided, and areas of consensus and controversy, identified. While the principal focus is on esophageal and gastric cancer, advances in the treatment of colorectal and pancreatic cancer are also discussed in some detail. This book will be of interest to every clinician involved in the care of patients with gastrointestinal malignancies.

This book constitutes the refereed proceedings of the First International Workshop on Computer Assisted and Robotic Endoscopy, CARE 2014, held in conjunction with MICCAI 2014, in Boston, MA, USA, in September 2014. The 12 papers presented focus on recent technical advances associated with computer vision; graphics; robotics and medical imaging; external tracking systems; medical device control systems; information processing techniques; endoscopy; planning and simulation.

Edited by some of the most experienced authors in the field, Biomedical Imaging provides comprehensive coverage on medical and biological imaging. Original research and critical reviews on software and hardware technologies for medical and biological imaging tasks are presented in the book, along with data processing in all imaging modalities for molecular, cellular, anatomical and functional imaging. Research topics include image acquisition, registration, reconstruction, multimodality methods, noise filtering and image enhancement, segmentation, classification and feature detection, model and atlas based imaging, as well as system development and acceleration technologies. Biomedical Imaging is comprised of 40 contributed chapters, which are organized in such a way that researchers, engineers, clinical practitioners and graduate students can easily follow up with relevant topics, and will benefit from reading the views of the domain experts in their fields.

Drug development today needs to balance agility, speed, and risk in defining probability of success for molecules, mechanisms, and therapeutic concepts. New techniques such as fMRI promise to be part of a sequence that could transform drug development. Although numerous review articles exist that discuss the use of imaging in drug development, no one source is available that combines the various techniques and includes a discussion of disease mapping. Imaging in CNS Drug Discovery and Development, Implications for Disease and Therapy will serve to distill the most salient developments in the use of imaging in drug development and disease mapping. It will launch evolving concepts that integrate new imaging technologies and paradigms with molecular medicine and molecular profiling ("monics") as well as consider the ethical issues that arise as a result of disease or state diagnosis and the use of imaging in the public eye.

This book, featuring more than 180 high spatial resolution images obtained with state-of-the-art MDCT and MRI scanners, depicts in superb detail the anatomy of the temporal bone, recognized to be one of the most complex anatomic areas. In order to facilitate identification of individual anatomic structures, the images are presented in the same way in which they emanate from contemporary imaging modalities, namely as consecutive submillimeter sections in standardized slice orientations, with all anatomic landmarks labeled. While various previous publications have addressed the topic of temporal bone anatomy, none has presented complete isotropic submillimeter 3D volume datasets of MDCT or MRI examinations. The Temporal Bone MDCT and MRI Anatomy offers radiologists, head and neck surgeons, neurosurgeons, and anatomists a comprehensive guide to temporal bone sectional anatomy that resembles as closely as possible the way in which it is now routinely reviewed, i.e., on the screens of diagnostic workstations or picture archiving and communication systems (PACS).

This book provides an overview of the current state-of-art in combining advances in biomedical imaging with intraoperative navigation and preoperative planning for urologic surgery. These advances hold great promise in improving diagnostic and therapeutic urologic interventions to improve patient outcomes. Leading experts in this exciting emerging field covers early clinical and pre-clinical applications of optical, ultrasound, cross-sectional and computer-assisted imaging in urologic surgery.

"Advances in Image-Guided Urologic Surgery" provides a unique and valuable resource for audience with clinical and research interest in minimally invasive surgery, endourology, urologic oncology, imaging and biomedical engineering.

This book offers an excellent review of the various rheumatological conditions, both common and uncommon, that may present on imaging on a daily basis. The book uses a unique format that will be beneficial for clinicians, radiologists, medical students, and consultant staff. The text is written by both rheumatology and radiology staff to provide a balanced approach. A clinical overview and the common clinical presentations are briefly reviewed for each condition followed by a more detailed discussion of imaging findings produced by the various imaging modalities, including radiographs, ultrasound, MRI, CT, and nuclear medicine. This book details the imaging of normal musculoskeletal anatomy and pathology; discusses image-guided musculoskeletal interventions; and examines disorders such as rheumatoid arthritis, connective tissue disease, osteoarthritis, osteonecrosis, infection-related arthritis, soft tissue calcification, and bone and synovial tumors. Featuring over 600 multi-part, high-resolution images of rheumatic diseases across current imaging modalities, Essential Imaging in Rheumatology offers up-to-date and complete information on the imaging of these disorders. Developed by the authors of Essential Imaging In Rheumatology are three new exciting interactive imaging Apps that enhance the invaluable information provided in the book. Rheumatology and imaging are closely linked specialties particularly with the expansion of the imaging armamentarium available to the rheumatologists in the last decade. Imaging has a strong impact on patient diagnosis, management and outcome, requiring both the rheumatologist and the radiologist to have a clear understanding of pathologies and their variable imaging appearances, differential diagnosis and optimal imaging algorithms. A primary focus of our " Imaging In Rheumatology Edicational Initiative " is to thus to stimulate interest in rheumatological imaging and as such we are delighted to provide a be able to provide our "UnRavelling Spondyloarthropathy" App free. ESIMR: Uncovering The Hand Radiograph iOS https://appsto.re/ca/ydsmfb.i Android https://play.google.com/store/apps/details?id=com.radiologyhand ESIMR: Clinical Case Challenge https://appsto.re/ca/bdsmfb.i https://play.google.com/store/apps/details?id=com.radiologyccc ESIMR: UnRavelling Spondyloarthropathy (Free) https://appsto.re/ca/Tzsmfb.i https://play.google.com/store/apps/details?id=com.radiologyspa

Molecular imaging plays an important role in drug discovery and advanced medical practice. A symposium of world leaders in drug research and development, molecular imaging, and medical therapy including regenerative treatment and radiation therapy has led to the publication of this book. Based on the proceedings of the symposium, many excellent ideas and valuable discussions are introduced that will guide the reader toward new advances in photon detection and protein modification as well as new developments in molecular imaging itself. Both protein modification and photon detection are emerging technologies that hold forth the promise of innovative strategies for drug discovery and medical care. The publication of these proceedings is a timely means of sharing significant experience and knowledge with many specialists all over the world. This book will be of great value to a wide variety of researchers in the fields of drug development and molecular imaging technologies, leading to integrated medical therapy and progress in human health.

Comparatively little is known about the risk of sudden death associated with exercise in young competitive athletes, and whether the benefits of sports activity outweigh the hazards of exercise-related fatal events is a clinical dilemma. This is only a small part of the story, however, as there are considerable effects of exercise whether it be at a competitive level or on a 'leisure' level on patients of all ages. This in itself is of massive importance to the cardiac patient population as exercise is a key component of effective recovery and recommended as central in the prevention of much cardiac disease.

This book provides a detailed and comprehensive overview of the role of diagnostic imaging in the assessment and management of trauma and polytrauma in children. The coverage includes imaging of injuries to the head, thorax, abdomen, bone and musculoskeletal system, with careful attention to the newest imaging techniques, imaging during the course of recovery and imaging of complications. A series of illustrative cases underline the prognostic value of imaging. In addition, an individual chapter is devoted to diagnostic imaging in cases of child abuse. The book concludes by discussing informed consent and medicolegal issues related to the imaging of pediatric traumatic emergencies. "Imaging Trauma and Polytrauma in Pediatric Patients "will be invaluable in enabling radiologists and clinicians to identify the main features and signs of injuries on a wide range of imaging techniques, including X-ray, ultrasonography, computed tomography and magnetic resonance imaging.

Image-Based Computational Modeling of the Human Circulatory and Pulmonary Systems provides an overview of the current modeling methods and applications enhancing interventional treatments and computer-aided surgery. A detailed description of the techniques behind image acquisition, processing and three-dimensional reconstruction are included. Techniques for the computational simulation of solid and fluid mechanics and structure interaction are also discussed, in addition to various cardiovascular and pulmonary applications. Engineers and researchers involved with image processing and computational modeling of human organ systems will find this a valuable reference.

Genitourinary Imaging - A Case Based Approach is a user friendly, portable guide that offers a comprehensive coverage of the subspecialty with an emphasis on all modalities. As subspecialty practice has become the norm in radiology, it becomes increasingly important to keep abreast of the latest information within the specialty that one is practising. The case based nature of this book, with modality independent content, allows the reader to assimilate practice specific information with ease. Full color images with tabular salient points, imaging algorithms and evidence based criterion support the text. Key points provide succinct explanations of the disease and an appropriate differential diagnosis, as well as providing a brief description of therapy and prognosis. Genitourinary Imaging - A Case Based Approach is aimed at residents and training and practicing genitourinary radiologists.

Nous sommes entrA(c) dans une civilisation de l'image et du numA(c)rique. L'imagerie mA(c)dicale numA(c)rique offre au clinicien des outils nouveaux, riches de promesses, et en pleine A(c)volution. Or ces techniques ne peuvent se concevoir sans utilisation de l'informatique. Mais cette imagerie utilise une information complexe, volumineuse, non structurA(c)e, souvent multimA(c)dia. Elle pose donc A l'informaticien des problA]mes difficiles qu'il ne sait pas encore parfaitement rA(c)soudre. Par consA(c)quent, la recherche d'outils informatique adaptA(c)s et la determination de leur meilleur mode d'utilisation est un domaine riche de possibilitA(c) de collaboration entre mA(c)decins et informaticiens. La premiA]re confA(c)rence organisA(c)e dans le cadre des Entretiens de Lyon a permis A des informaticiens et A des mA(c)decins, ensemble, d'une part d'A(c)tudier les aspects informatiques des bases de donnA(c)es d'imagerie mA(c)dicale, d'autre part de rechercher comment faire A(c)voluer les systA]mes d'imagerie mA(c)dicale (PACS) vers une intA(c)gration dans des systA]mes d'information hospitaliers, d'autre part encore de dA(c)terminer par quelles techniques pourraient Aatre obtenues et mieux visualisA(c)es des images mA(c)dicales notamment tridimensionnelles, enfin d'A(c)tudier les systA]mes experts mA(c)dicaux et les problA]mes d'intelligence artificielle appliquA(c)e A la mA(c)decine.

This volume highlights the remarkable new developments in brain imaging, including those that apply magnetic resonance imaging (MRI) and Positron Emission Tomography (PET), that allow us to non invasively study the living human brain in health and in disease. These technological advances have allowed us to obtain new and powerful insights into the structure and function of the healthy brain as it develops across the life cycle, as well as the molecular make up of brain systems and circuits as they develop and change with age. New brain imaging technologies have also given us new insights into the causes of many common brain disorders, including ADHD, schizophrenia, depression and Alzheimer's disease, which collectively affect a large segment of the population. These new insights have major implications for understanding and treating these brain disorders, and are providing clinicians with the first ever set of biomarkers that can be used to guide diagnosis and monitor treatment effects. The advances in brain imaging over the last 20 years, summarized in this volume, represent a major advance in modern biomedical sciences.