Edited by some of the most experienced authors in the field, Biomedical Imaging provides comprehensive coverage on medical and biological imaging. Original research and critical reviews on software and hardware technologies for medical and biological imaging tasks are presented in the book, along with data processing in all imaging modalities for molecular, cellular, anatomical and functional imaging. Research topics include image acquisition, registration, reconstruction, multimodality methods, noise filtering and image enhancement, segmentation, classification and feature detection, model and atlas based imaging, as well as system development and acceleration technologies. Biomedical Imaging is comprised of 40 contributed chapters, which are organized in such a way that researchers, engineers, clinical practitioners and graduate students can easily follow up with relevant topics, and will benefit from reading the views of the domain experts in their fields.

Traditional research methodologies in the human respiratory system have always been challenging due to their invasive nature. Recent advances in medical imaging and computational fluid dynamics (CFD) have accelerated this research. This book compiles and details recent advances in the modelling of the respiratory system for researchers, engineers, scientists, and health practitioners. It breaks down the complexities of this field and provides both students and scientists with an introduction and starting point to the physiology of the respiratory system, fluid dynamics and advanced CFD modeling tools. In addition to a brief introduction to the physics of the respiratory system and an overview of computational methods, the book contains best-practice guidelines for establishing high-quality computational models and simulations. Inspiration for new simulations can be gained through innovative case studies as well as hands-on practice using pre-made computational code. Last but not least, students and researchers are presented the latest biomedical research activities, and the computational visualizations will enhance their understanding of physiological functions of the respiratory system.

Comparatively little is known about the risk of sudden death associated with exercise in young competitive athletes, and whether the benefits of sports activity outweigh the hazards of exercise-related fatal events is a clinical dilemma. This is only a small part of the story, however, as there are considerable effects of exercise whether it be at a competitive level or on a 'leisure' level on patients of all ages. This in itself is of massive importance to the cardiac patient population as exercise is a key component of effective recovery and recommended as central in the prevention of much cardiac disease.

Neutron capture therapy (NCT) is based on the ability of the non-radioactive isotope boron-10 to capture thermal neutrons with very high probability and immediately to release heavy particles with a path length of one cell diameter, which in principle allows for tumor cell-selective high-LET particle radiotherapy. This book provides a comprehensive summary of the progress made in NCT in recent years. Individual sections cover all important aspects, including neutron sources, boron chemistry, drugs for NCT, dosimetry, and radiation biology. The use of NCT in a variety of malignancies and also some non-malignant diseases is extensively discussed. NCT is clearly shown to be a promising modality at the threshold of wider clinical application. All of the chapters are written by experienced specialists in language that will be readily understood by all participating disciplines.

This book is a concise guide to ordering radiology tests for diagnosis and treatment and provides best practice guidelines for patients whose management depends on a clinical question that is best approached through imaging. Organized primarily by organ system, it outlines considerations in selecting the most efficacious imaging studies based on the clinical history, laboratory values, and physical findings to arrive cost-effectively at a correct diagnosis. It also explores the current limitations of each imaging modality and presents evidence-based information to insure that patient safety considerations are observed when ordering potentially dangerous examinations. Clinician's Guide to Diagnostic Imaging is a valuable resource for all physicians who regularly order imaging studies, including primary care physicians, family practitioners, internists, and surgeons alike. Further, this volume serves as an invaluable reference for medical students who are exposed to medical imaging for their first time or who are rotating through a radiology elective in medical school.

Diagnosing neurodegenerative diseases can prove particularly intimidating to clinicians, because many times the diagnosis cannot be critically "confirmed" by a simple test. New imaging modalities have advanced to the point of high resolution, morphological, metabolic and functional analysis. Computed tomography, magnetic resonance, nuclear medicine and molecular imaging have recently emerged as outstanding non-invasive techniques for the study of the neurodegenerative disorders. Imaging in Neurodegenerative Disorders covers all the imaging techniques and new exciting methods like new tracers, biomarker, metabolomic and gene-array profiling, potential for applying such techniques clinically, and offers present and future applications as applied to the neurodegenerative disorders with the most world renowned scientists in these fields. This book is an invaluable resource for researchers, clinicians, and trainees in neuroscience, neurology, psychiatry, and radiology.

This book provides a comprehensive up-to-date review of optical approaches used in brain imaging and therapy. It covers a variety of imaging approaches including diffuse optical imaging, laser speckle imaging, photoacoustic imaging and optical coherence tomography. A number of laser-based therapeutic techniques are reviewed, including photodynamic therapy, fluorescence guided resection and photothermal therapy. Fundamental principles and instrumentation are discussed for each imaging and therapeutic approach.

A single source of information about pathologic lesions of the adrenal, the urinary tract, and the male genital system, minimizing the need to consult numerous texts of limited scope, this book contains gross photos and photomicrographs of virtually every pathologic entity, and variants of those entities. The book is lavishly illustrated with images accompanied by text that explains the visual images, highlighting key diagnostic features and providing brief but helpful discussions of the differential diagnosis. This book is designed for practicing pathologists and pathologists in training as well as urologists, GU radiologists, GU radiation oncologists, and GU medical oncologists.

Terahertz biomedical imaging has become an area of interest due to its ability to simultaneously acquire both image and spectral information. Terahertz imaging systems are being commercialized, with increasing trials performed in a biomedical setting. As a result, advanced digital image processing algorithms are needed to assist screening, diagnosis, and treatment. "Pattern Recognition and Tomographic Reconstruction" presents these necessary algorithms, which will play a critical role in the accurate detection of abnormalities present in biomedical imaging. Terhazertz tomographic imaging and detection technology contributes to the ability to identify opaque objects with clear boundaries, and would be useful to both in vivo and ex vivo environments, making this book a must-read for anyone in the field of biomedical engineering and digital imaging.

Intraoperative imaging technologies have taken an ever-increasing role in the daily practice of neurosurgeons and the increasing attention and interest necessitated international interaction and collaboration. The Intraoperative Imaging Society was formed in 2007. This book brings together highlights from the second meeting of the Intraoperative Imaging Society, which took place in Istanbul-Turkey from June 14 to 17, 2009. Included within the contents of the book is an overview of the emergence and development of the intraoperative imaging technology as well as a glimpse on where the technology is heading. This is followed by in detail coverage of intraoperative MRI technology and sections on intraoperative CT and ultrasonography. There are also sections on multimodality integration, intraoperative robotics and other intraoperative technologies. We believe that this book will provide an up-to date and comprehensive general overview of the current intraoperative imaging technology as well as detailed discussions on individual techniques and clinical results.

In modern medicine, imaging is the most effective tool for diagnostics, treatment planning and therapy. Almost all modalities have went to directly digital acquisition techniques and processing of this image data have become an important option for health care in future. This book is written by a team of internationally recognized experts from all over the world. It provides a brief but complete overview on medical image processing and analysis highlighting recent advances that have been made in academics. Color figures are used extensively to illustrate the methods and help the reader to understand the complex topics.

This book constitutes the thoroughly refereed post-conference proceedings of the Third International Workshop on Statistical Atlases and Computational Models of the Heart: Imaging and Modelling Challenges, STACOM 2012, held in conjunction with MICCAI 2012, in Nice, France, in October 2012.
The 42 revised full papers were carefully reviewed and selected from numerous submissions. The papers are organized in topical sections on CFD challenge, DE-MRI segmentation challenge, LV landmark detection challenge, motion tracking analysis challenge, and regular papers.

Liver metastases are a frequent and often fatal occurrence in cancer patients, particularly those with malignancies of the gastrointestinal (GI) tract. While recent improvements in surgical techniques and a more aggressive approach to resection of liver metastases have improved long term survival for some patients, most patients with hepatic metastases still succumb to their disease. To improve these dismal statistics, a better understanding of the biology of liver metastasis, particularly the early stages that can be targeted for prevention, is essential.

Once cancer cells enter the liver, several different scenarios may occur. The cancer cells may be immediately destroyed by local defence mechanisms, they may enter a state of dormancy as solitary cells and never produce a metastasis, initiate a short-lived process of proliferation that is aborted before a metastasis is established or actively proliferate to form macrometastases. The chapters in Part I of this book provide insight into the cellular/molecular mechanisms that determine which of these scenarios prevails. Written by experts researchers in the filed of metastasis, these chapters provide state-of-the art reviews on the cellular and molecular processes that impact the early stages of the metastatic process. The unique microenvironment of the liver, its various anatomical, cellular and molecular features and the impact they have on metastasis are highlighted. In addition, the role of inflammation (pre-existing and tumor-induced), host innate and adaptive immune responses, cytokines, chemokines, growth factors and the unique molecular signatures of metastatic tumor cells are reviewed with an underscoring of the translational implications of the current state of knowledge.

Against this background, the chapters in Part II of the book provide critical reviews on major aspects of the clinical management of hepatic metastases. These include imaging strategies, surgical and chemotherapeutic treatment approaches and the use of targeted biological therapeutics such as anti-angiogenic drugs as treatment modalities.

By combining information on biological and clinical aspects of liver metastasis, this volume will serve as an excellent resource for scientists, clinicians, clinician/ scientists and trainees in the domains of oncology, surgical oncology, hepatobiliary physiology and radiology. "

An informative and comprehensive review from the leading researchers in the field, this book provides a complete one-stop guide to neuroimaging techniques and their application to a wide range of neuropsychiatric disorders. For each disorder or group of disorders, separate chapters review the most up-to-date findings from structural imaging, functional imaging and/or molecular imaging. Each section ends with an overview from a internationally-renowned luminary in the field, addressing the question of 'What do we know and where are we going?' Richly illustrated throughout, each chapter includes a 'summary box', providing readers with explicit take-home messages. This is an essential resource for clinicians, researchers and trainees who want to learn how neuroimaging tools lead to new discoveries about brain and behaviour associations in neuropsychiatric disorders.

Specialists in cardiac imaging offer their extensive experience of performing and interpreting myocardial perfusion studies with thallium 201 and single photon emission tomography in this unique teaching atlas which contains over 1500 colour illustrations.

This highly comprehensive and informed textbook has been prepared by the Cardiovascular Magnetic Resonance section of the European Society of Cardiology association on imaging, the EACVI. The EACVI Textbook of Cardiovascular Magnetic Resonance is the authority on the subject. The textbook is aligned with ESC Core Curriculum and EACVI Core Syllabus for CMR. It is a practical resource and provides a disease orientated outlook on the subject. Structured with thirteen clear and detailed sections, ranging from Physics to Methodology, and featuring specific sections on ischemic heart disease, myocardial disease, pericardial disease, and congenital heart disease and adult congenital heart disease, The EACVI Textbook of Cardiovascular Magnetic Resonance provides extensive knowledge across the entire subject area in CMR. Beautifully illustrated and physical principles enriched with schematic animations, the textbook is advanced further with key video content based on clinical cases. Written by leading experts in the field from across the world, the textbook aims to summarise the existing research and clinical evidence for the various CMR indications and provide an invaluable resource for cardiologists and radiologists across the board. The textbook is ideal for cardiologists and radiologists new to the field of Cardiovascular Magnetic Resonance, those preparing for ESC certification in CMR, and those established in the field wishing to gain a deep understanding of CMR. Online access to the digital version is included with purchase of the print book, with accompanying videos referenced within the text available on Oxford Medicine Online.

Through 145 clinically-relevant cases, Musculoskeletal Imaging Cases covers the full spectrum of imaging for this field. Part of the Cases in Radiology series, this book follows the easy-to-learn case format of question and answer, complete with concise summaries and a generous amount of top-quality images. Pathologies addressed in the cases include: arthritis, bone and soft tissue tumors and tumor-like conditions, infection, trauma, internal derangement of joints, metabolic and hematologic disorders affecting the MSK system, bone marrow, infection, and pediatric problems. Within their sections, cases appear in a random order for the beneficial self-assessment experience of the reading cases as unknowns. Musculoskeletal Imaging Cases is ideal for the resident preparing for the boards, or the radiologist in need of a quick review.

by Mario Banche, M.D. IX The neologism "coloscopy" (colonscopy, colonoscopy) is the latest addition to the vocabulary of endoscopy of the large intestine. just as the term "duodenoscopy" was in endoscopy of the upper digestive tract a few years ago. With the advent of the coloscope it is now possible to examine the large bowel more extensively and effectively than was formerly possible with the use of its rigid forerunner, the rectosigmoidoscope. The earliest rectoscopes, 11 endoscopes" introduced during the 19th century by Segales and Desormeaux (1826, 1853), were conceived for many uses-inspection of the urethra, bladder, uterus, rectum. Successive improvements eventually led to the construction of an instrument designed exclusively for endoscopy of the rectum and sigmoid colon (Bensaude, 1907). Over the following years the rectoscope underwent no substantial change and thus an abundant and homogeneous literature accrued in which the available instruments and their use were described while the endoscopic pathologic nosography and corresponding endoscopic pictures of the rectum and sigmoid colon were codified, illustrated first by simple sketches and later by still and motion photography. The literature contains many excellent publications, some in monograph form.

This book constitutes the refereed proceedings of the 5th International Workshop on Biomedical Image Registration, WBIR 2012, held in Nashville, Tennessee, USA, in July 2012. The 20 full papers and 11 poster papers included in this volume were carefully reviewed and selected from 44 submitted papers. They full papers are organized in the following topical sections: multiple image sets; brain; non-rigid anatomy; and frameworks and similarity measures.

Current techniques for studying biological macromolecules and their interactions are based on the application of physical methods, ranging from classical thermodynamics to more recently developed techniques for the detection and manipulation of single molecules. Reflecting the advances made in biophysics research over the past decade, and now including a new section on medical imaging, this new edition describes the physical methods used in modern biology. All key techniques are covered, including mass spectrometry, hydrodynamics, microscopy and imaging, diffraction and spectroscopy, electron microscopy, molecular dynamics simulations and nuclear magnetic resonance. Each method is explained in detail using examples of real-world applications. Short asides are provided throughout to ensure that explanations are accessible to life scientists, physicists and those with medical backgrounds. The book remains an unparalleled and comprehensive resource for graduate students of biophysics and medical physics in science and medical schools, as well as for research scientists looking for an introduction to techniques from across this interdisciplinary field.

Revolutionary advances in imaging technology that provide high resolution, 3-D, non-invasive imaging of biological subjects have made biomedical imaging an essential tool in clinical medicine and biomedical research. Key technological advances include MRI, positron emission tomography (PET) and multidetector X-ray CT scanners. Common to all contemporary imaging modalities is the creation of digital data and pictures. The evolution from analog to digital image data is driving the rapidly expanding field of digital image analysis. Scientists from numerous disciplines now require in-depth knowledge of these complex imaging modalities. Introduction to the Science of Medical Imaging presents scientific imaging principles, introduces the major biomedical imaging modalities, reviews the basics of human and computer image analysis and provides examples of major clinical and research applications. Written by one of the world's most innovative and highly respected neuroradiologists, Introduction to the Science of Medical Imaging is a landmark text on image acquisition and interpretation.

Core Concepts in Colonoscopy covers all aspects of diagnostic and therapeutic colonoscopy, emphasizing overarching concepts that gastroenterology fellows and physicians must know to achieve success in both the technical and cognitive aspects of the procedure. In this comprehensive resource, Dr. Douglas G. Adler and his contributors provides a straightforward and practical review of colonoscopy. Core Concepts in Colonoscopy aims to address and convey the core concepts of colonoscopy: from the structure and function of the colonoscope itself, to insertion techniques, loop formation and reduction, polypectomy techniques for any situation, the avoidance and management of perforations and other adverse events, as well as advanced techniques including (but not limited to) endoscopic mucosal resection and colonic stenting. Each chapter inside Core Concepts in Colonoscopy is lavishly illustrated with multiple key images to accentuate and enhance the written text, as well as a plethora of tips, tricks, and accumulated points of wisdom in each chapter on all facets of colonoscopy. Additional Website Component! Core Concepts in Colonoscopy is accompanied by a video website with specific videos connected to individual chapters that will illustrate basic and advanced colonoscopic techniques from many leading experts and will further enhance the learning process. The addition of the video website allows for a more robust learning experience and allows the reader to watch, listen, view repeatedly, and reinforces the techniques presented in the written text. GI fellows, junior gastroenterologists, and even advanced physicians will appreciate Core Concepts in Colonoscopy because of the user-friendly and efficient structure that allows for the material to be quickly read, as well as easily absorb the wealth of key practical knowledge found inside.

Biomedical imaging is a relatively young discipline that started with Conrad Wilhelm Roentgen's discovery of the x-ray in 1895. X-ray imaging was rapidly adopted in hospitals around the world. However, it was the advent of computerized data and image processing that made revolutionary new imaging modalities possible. Today, cross-sections and three-dimensional reconstructions of the organs inside the human body is possible with unprecedented speed, detail and quality. This book provides an introduction into the principles of image formation of key medical imaging modalities: X-ray projection imaging, x-ray computed tomography, magnetic resonance imaging, ultrasound imaging, and radionuclide imaging. Recent developments in optical imaging are also covered. For each imaging modality, the introduction into the physical principles and sources of contrast is provided, followed by the methods of image formation, engineering aspects of the imaging devices, and a discussion of strengths and limitations of the modality. With this book, the reader gains a broad foundation of understanding and knowledge how today's medical imaging devices operate. In addition, the chapters in this book can serve as an entry point for the in-depth study of individual modalities by providing the essential basics of each modality in a comprehensive and easy-to-understand manner. As such, this book is equally attractive as a textbook for undergraduate or graduate biomedical imaging classes and as a reference and self-study guide for more specialized in-depth studies.

Featuring 150 cases and over 400 high-quality images, Pediatric Imaging Cases offers a complete survey of the field of pediatric radiology. Cases are formatted as questions and answers, allowing for self-assessment, complete with relevant radiologic findings, differential diagnoses, teaching points, further steps in management, and suggested further readings. Part of the Cases in Radiology series, this book offers a comprehensive overview of the clinical issues of pediatric radiology: cardiovascular system, gastrointestinal system, genitourinary system, spine, neuroradiology, chest and airway, and musculoskeletal system. Ideal for residents preparing for board exams as well as seasoned clinicians wishing to test their knowledge, Pediatric Imaging Cases provides a thorough investigation of the field.

Practical and clinically oriented, Specialty Imaging: Acute and Chronic Pain Intervention provides unique, authoritative guidance on the use of image-guided techniques for periprocedural analgesia and pain management procedures. Ideal for practicing and trainee interventional radiologists, pain physicians, and anesthesiologists, this one-stop resource is tailored to your decision support needs, with coverage of everything from neuroanatomy and specific pain conditions to interventional procedures for acute and chronic pain. Provides up-to-date content informed by best practices and the perspectives of both interventional radiology and anesthesiology Discusses key topics such as multimodal opioid sparing techniques as adjuncts and alternatives to the use of opioids for acute pain management, as well as shared decision making in interventional radiology pain management Demonstrates the new fascial pain blocks as well as sympathetic nerve blocks for periprocedural analgesia during interventional procedures Covers adult and pediatric acute and chronic pain conditions Integrates neuroanatomy and the "why" of clinical procedures for a better understanding of the pathways and various options for therapeutic intervention Presents information consistently, using a highly templated format with bulleted text for quick, easy reference Begins each section with a discussion of neuroanatomy, followed by succinct chapters that provide "how-to" information on a clinically useful, imaging-guided interventional procedure for treating a specific acute or chronic pain condition Features procedural videos and clear, high-quality drawings for visual reinforcement, e.g., sequential illustrations that show where nerves are located through successive peeling of anatomic layers Includes an Expert ConsultT eBook version that allows you to search all text, figures, and references on a variety of devices