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Introduction to Electrophysiological Methods and Instrumentation
covers all topics of interest to electrophysiologists,
neuroscientists and neurophysiologists, from the reliable
penetration of cells, the behaviour and function of the equipment,
to the mathematical tools available for analysing data. It
discusses the pros and cons of techniques and methods used in
electrophysiology and how to avoid their pitfalls.
In recent decades, the use of neuroimaging techniques has resulted in outstanding progress in the diagnosis and management of neurological diseases, and this is particularly true of those diseases that affect the white matter of the brain and spinal cord. This book, written by internationally acclaimed experts, comprises a series of comprehensive and up-to-date reviews on the use of MR imaging in these major neurological conditions. The diverse available MR techniques, such as magnetization transfer MRI, diffusion-weighted MRI, MR spectroscopy, functional MRI, cell-specific MRI, perfusion MRI, and microscopic imaging with ultra-high field MRI, offer an extraordinarily powerful means of gaining fundamental in vivo insights into disease processes. The strengths and weaknesses of all these techniques in the study of multiple sclerosis and other relevant diseases are extensively considered. After an introductory section on neuroimaging technology, subsequent sections address disorders of myelination, demyelinating diseases, immune-mediated disorders, and white matter disorders related to aging and other conditions. This book provides a valuable summary of the state of the art in the field, and defines important areas for future research.
Over the last two decades, there have been numerous exciting developments in the surgical field of articular cartilage repair. Magnetic resonance imaging plays a critical role in pre-operative surgical planning, through its ability to identify the extent and severity of cartilage lesions. It also plays an important role in post-operative management, by allowing surgeons to noninvasively monitor the morphological status of repaired cartilage tissue.This book covers recent advances in ultra high field MRI and biochemical MRI techniques such as T2 mapping, delayed gadolinium enhanced MRI of cartilage (dGEMRIC), gagCEST and sodium MRI. It is written by a multidisciplinary team including basic scientists, radiologists, orthopaedic surgeons and biomedical engineers. The volume is an ideal reference guide for musculoskeletal radiologists, basic research scientists, orthopedic surgeons and biomedical engineers etc.
Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The acclaimed pocket atlas of the most common pathologic conditions seen on CT and MRI - more essential than ever, with new images and cases Designed for quick look-up at the point of care, this concise handbook provides technologists and students with CT and MRI findings of 200 pathologic conditions most often seen in day-to-day practice, along with pertinent clinical information. Each pathology listed has a single page of text accompanied by MRI and/or CT images, often providing multiple perspectives of the same pathology. The text includes a description of etiology, epidemiology, signs and symptoms, imaging characteristics, for CT and MRI, treatment, and prognosis statements. The book also includes a valuable opening section on the Principles of Imaging in Computed Tomography and Magnetic Resonance Imaging and an informative section on Contrast Media. Designed for portability and ease of use, this handbook enables technologists to quickly check pathologic imaging findings and essential clinical information without having to refer to large, heavy textbooks
Written by experts in the field, this beautifully illustrated text/atlas provides the tools you need to directly visualize and interpret cranial CT and MR images. It reviews with exacting detail the normal anatomic brain structures identified on sagittal, coronal, and axial imaging planes. Use this book to make accurate and complete neurological assessments at the earliest possible stages - before reaching the sectioning or operating table. This revised and expanded third edition contains nearly 600 illustrations - most in color - that provide graphic representations of brain structures, arteries, arterial territories, veins, nerves and neurofunctional systems. The illustrations depict anatomic structures in shades of gray similar to the way they are seen in CT and MR images. Clinically relevant, easily readable, and clearly organized, this well-illustrated book is an essential introduction to the field for medical students and residents in neurology, neurosurgery, neuroradiology, and radiology. Practicing specialists will also benefit from this practical day-to-day tool.
Dermoscopy is a noninvasive skin imaging technique that uses optical magnification and either liquid immersion or cross-polarized lighting to make subsurface structures more easily visible when compared to conventional clinical images. It allows for the identification of dozens of morphological features that are particularly important in identifying malignant melanoma. Dermoscopy Image Analysis summarizes the state of the art of the computerized analysis of dermoscopy images. The book begins by discussing the influence of color normalization on classification accuracy and then: Investigates gray-world, max-RGB, and shades-of-gray color constancy algorithms, showing significant gains in sensitivity and specificity on a heterogeneous set of images Proposes a new color space that highlights the distribution of underlying melanin and hemoglobin color pigments, leading to more accurate classification and border detection results Determines that the latest border detection algorithms can achieve a level of agreement that is only slightly lower than the level of agreement among experienced dermatologists Provides a comprehensive review of various methods for border detection, pigment network extraction, global pattern extraction, streak detection, and perceptually significant color detection Details a computer-aided diagnosis (CAD) system for melanomas that features an inexpensive acquisition tool, clinically meaningful features, and interpretable classification feedback Presents a highly scalable CAD system implemented in the MapReduce framework, a novel CAD system for melanomas, and an overview of dermatological image databases Describes projects that made use of a publicly available database of dermoscopy images, which contains 200 high-quality images along with their medical annotations Dermoscopy Image Analysis not only showcases recent advances but also explores future directions for this exciting subfield of medical image analysis, covering dermoscopy image analysis from preprocessing to classification.
Measurement of Cardiac Deformations from MRI: Physical and Mathematical Models describes the latest imaging and imag analysis techniques that have been developed at leading centers for the visualization, analysis, and understanding of normal and abnormal cardiac motion with magnetic resonance imaging (MRI). The use of MRI in measuring cardiac motion is particularly important because MRI is non-invasive, and it is the only modality capable of imaging detailed intramural motion within the myocardium. Biomedical engineers, medical physicists, computer scientists, and physicians interested in learning about the latest advances in cardiovascular MRI should find this book to be a valuable educational resource. In particular, it is more tutorial in nature than most of the technical papers where the research was originally published. Practitioners and researchers working in the field of cardiovascular MRI will find the book to be filled with practical technical details and references to other work, enabling the implementation of existing methods and serving as a basis for further research in the area.
This volume is unique in reporting on strategies for the application of molecular targeted imaging agents such as antibodies, peptides, receptors and contrast agents in the biologic grading of tumors, differential diagnosis of tumors, prediction of therapeutic response and monitoring tumor response to treatment. It also includes updated information on the imaging of tumor angiogenesis, hypoxia, apoptosis and gene delivery as well as expression in the understanding and utility of tumor molecular biology for better cancer management.
This scholarly set of well-harmonized volumes provides indispensable and complete coverage of the exciting and evolving subject of medical imaging systems. Leading experts on the international scene tackle the latest cutting-edge techniques and technologies in an in-depth but eminently clear and readable approach.Complementing and intersecting one another, each volume offers a comprehensive treatment of substantive importance to the subject areas. The chapters, in turn, address topics in a self-contained manner with authoritative introductions, useful summaries, and detailed reference lists. Extensively well-illustrated with figures throughout, the five volumes as a whole achieve a unique depth and breath of coverage.As a cohesive whole or independent of one another, the volumes may be acquired as a set or individually.
Goals of the Book Overthelast thirty yearsthere has been arevolutionindiagnostic radiology as a result oftheemergenceofcomputerized tomography (CT), which is the process of obtaining the density distribution within the human body from multiple x-ray projections. Since an enormous variety of possible density values may occur in the body, a large number of projections are necessary to ensure the accurate reconstruction oftheir distribution. There are other situations in which we desire to reconstruct an object from its projections, but in which we know that the object to be recon- structed has only a small number of possible values. For example, a large fraction of objects scanned in industrial CT (for the purpose of nonde- structive testing or reverse engineering) are made of a single material and so the ideal reconstruction should contain only two values: zero for air and the value associated with the material composing the object. Similar as- sumptions may even be made for some specific medical applications; for example, in angiography ofthe heart chambers the value is either zero (in- dicating the absence of dye) or the value associated with the dye in the chamber. Another example arises in the electron microscopy of biological macromolecules, where we may assume that the object to be reconstructed is composed of ice, protein, and RNA. One can also apply electron mi- croscopy to determine the presenceor absence ofatoms in crystallinestruc- tures, which is again a two-valued situation.
The 1999 international conference on Information Processing in Medical Imaging (IPMI '99) was the sixteenth in the series of biennial meetings and followed the successful meeting in Poultney, Vermont, in 1997. This year, for the rst time, the conference was held in central Europe, in the historical Hungarian town of Visegr ad, one of the most beautiful spots not only on the Danube Bend but in all Hungary. The place has many historical connections, both national and international. The castle was once a royal palace of King Matthias. In the middle ages, the Hungarian, Czech, and Polish kings met here. Recently, after the summit meeting of reestablished democracies in the area, it became a symbol for the cooperation between central European countries as they approached the European Union. It was thus also symbolic to bring IPMI, in the year of the 30th anniversary of its foundation, to this place, and organize the meeting with the close cooperation of local and traditional western organizers. It also provided a good opportunity to summarize brie?y a history of IPMI for those who were new to the IPMI conference. This year we received 82 full paper submissions from all over the world. Of these, 24 were accepted as oral presentations. These were divided into 6 sessions. In spite of our e orts, it was found to be impossible to make these sessions fully balanced and homogeneous.
The definite treatment ofaortic disorders goes back to the resection ofisthmic coarctation by Clarence Crafoord in 1944. It took another third of a century until all portionsofthe aortabecameaccessible to highly standardized surgery. This progress, delayed as it was in relation to most other cardiovascular in- terventions, depended on the availability of safe protective methods for the heart and central nervous system, of reliable vascular grafts and atraumatic instruments, novel suture material and tissue adhesives. The development ofadvanced surgical techniques went hand in hand with, and depended upon, the emergence of proper diagnostic tools, starting with aortography andultimately culminating inCT-scanning, transesophageal echo- cardiography and magnetic resonance imaging. These tools now allow for the rational planning and conductofany aortic intervention which may be surgical or, more recently, catheter-guided. Nienaber's and Fattori's new book aptly is addressing both the diagnos- tic procedure as well as the treatment of aortic disease. The authors are well known experts in the fields of advanced diagnostics of aortic pathology, both spearheading a remarkably innovative group of aortic interventionalists as well. On account of their expertise, their chapters are able to answer any question rising in conjunction with these subjects.
Medical Image Databases covers the new technologies of biomedical imaging databases and their applications in clinical services, education, and research. Authors were selected because they are doing cutting-edge basic or technology work in relevant areas. This was done to infuse each chapter with ideas from people actively investigating and developing medical image databases rather than simply review the existing literature. The authors have analyzed the literature and have expanded on their own research. They have also addressed several common threads within their generic topics. These include system architecture, standards, information retrieval, data modeling, image visualizations, query languages, telematics, data mining, and decision supports. The new ideas and results reported in this volume suggest new and better ways to develop imaging databases and possibly lead us to the next information infrastructure in biomedicine. Medical Image Databases is suitable as a textbook for a graduate-level course on biomedical imaging or medical image databases, and as a reference for researchers and practitioners in industry.
." . . this volume has much to offer readers interested in science and technology and constructs of the body, expecially the 'normal' body."--"Disabilities Studies Quarterly"
Hand in hand with such health crises as HIV/AIDS, breast cancer, and the resurgence of tuberculosis has come an explosion of scientific and medical technologies. As technology documents illness with ever greater precision and clarity, the knowledge and vocabulary of patients is being similarly expanded by activists, consumer advocates, and artists working with new electronic technologies.
Into this breach steps The Visible Woman, collecting professional, academic, and lay viewpoints on gender and the role of visual and textual representation in contemporary health and science. From fetal photography and mammography to mental retardation and chronic fatigue syndrome, The Visible Woman reveals how identities are constructed in medical research and public health initiatives, as well as in popular press accounts of health. New ways of seeing the body, through medical imaging, plastic and sexual surgery, and services for people with disabilities, are all informed, the book argues, by a broader cultural fascination with visuality and media.
Emphasizing the authors' first-hand experiences as medical practitioners, activists, scholars, and patients, The Visible Woman breaks with more established approaches that cast patients as passive objects of medical inquiry, and medical professionals as perpetrators of institutional exploitation in the name of the public good. Asking what it means to be on both ends of the microscope, The Visible Woman highlights the complex perspectives of medical and scientificpractitioners who themselves exist both inside and outside their workplaces and professional identities.
The contributors are Michael BA(c)rubA(c), Lisa Cartwright, Stacie A. Colwell, Richard Cone, Anne Eckman, Valerie Hartouni, Janet Lyon, Emily Martin, Gaye Naismith, Mark Rose, Ella Shohat, Vivian Sobchack, Carol Stabile, Sandy Stone, and Paula A. Treichler.
Looking for the resource to help your students fully understand and retain critical knowledge of sectional anatomy? Allow us to introduce this new edition of" Introduction to""Sectional Anatomy." Focusing on presenting this highly visual an dynamic topic in a way that makes it engaging and accessible to students, "Introduction to Sectional Anatomy"begins with key terminology and concepts and then moves through the body from head to toe. This new edition has been completely updated to include the most current imaging modalities, including ultrasound, MR, and PET/CT, so your students are fully equipped for what they will encounter in practice. Here's what you can expect to find inside "Introduction to Sectional Anatomy," Third Edition...""- A design that makes it easy for students to compare images from several patients- Clinical cases demonstrating how knowledge of sectional anatomy is applied in practice- Chapter objectives that help students study more efficiently- Clinical application questions at the end of each chapter that review students' understanding of essential concepts
Blume's Atlas of Pediatric and Adult EEGs combines Dr. Blume's two classic books, the Atlas of Adult EEG and the Atlas of Pediatric EEG, into a single resource for adult and pediatric epileptologists, neurologists, and neurology trainees. This new, consolidated atlas features substantially more digitally obtained illustrations, offers hundreds of new recordings that demonstrate seizure states, normal phenomena, and artifacts, and expands on ICU bedside monitoring with the four-channel abbreviated recording typically used in the intensive care setting. The authors provide examples of typical waveforms and the expected variances.
A companion website offers the fully searchable text and
hundreds of additional EEG recordings with captions. Users can test
their knowledge with the caption "off," then click to confirm the
Non-Invasive Imaging of Atherosclerosis is a primer, reference and review of some of the key features of current activities in the field of atherosclerosis. The Editors' goal is to provide material and stimulating ideas to basic scientists and clinical researchers in order to extend the application of vascular imaging and to further develop methods suitable for investigation of the arterial wall. The first section presents current knowledge about pathology, vascular mechanics and compensatory mechanisms active during atherogenesis. It explores the early lesion, complications of plaques and early detection of plaques. Section II reviews several key methodological issues of B-mode ultrasound imaging and some of the most current data. Quantitative B-mode ultrasound is an established non-invasive tool widely used in large epidemiologic studies and interventional clinical trials of atherosclerosis. The last section addresses the most promising areas of development in vascular imaging. This involves new techniques to evaluate the atherosclerotic bed, to follow atheroma progression/regression and to evaluate vascular mechanics in atherosclerotic arteries. The last chapter places the application of non-invasive imaging in perspective.
14 contributions present mathematical models for different imaging techniques in medicine and nondestructive testing. The underlying mathematical models are presented in a way that also newcomers in the field have a chance to understand the relation between the special applications and the mathematics needed for successfully treating these problems. The reader gets an insight into a modern field of scientific computing with applications formerly not presented in such form, leading from the basics to actual research activities.
This book offers the first comprehensive overview of artificial intelligence (AI) technologies in decision support systems for diagnosis based on medical images, presenting cutting-edge insights from thirteen leading research groups around the world. Medical imaging offers essential information on patients' medical condition, and clues to causes of their symptoms and diseases. Modern imaging modalities, however, also produce a large number of images that physicians have to accurately interpret. This can lead to an "information overload" for physicians, and can complicate their decision-making. As such, intelligent decision support systems have become a vital element in medical-image-based diagnosis and treatment. Presenting extensive information on this growing field of AI, the book offers a valuable reference guide for professors, students, researchers and professionals who want to learn about the most recent developments and advances in the field.
Essential reading for both clinicians and researchers, this comprehensive resource covers what you need to know about the basic principles of perfusion, as well as its many clinical applications. Broad coverage outlines the overarching framework that interlinks methods such as DSC, DCE, CTP, and ASL. International experts in the field demonstrate how perfusion and pharmacokinetic imaging can be effectively used to analyze medical conditions, helping you reach accurate diagnoses and monitor disease progression and response to therapy. Key Features Provides thorough coverage of CT and MR perfusion , including clinical applications, in a single, convenient volume. Covers every area relevant to perfusion : image acquisition and reconstruction methods, contrast agent based methods for measuring organ perfusion and pharmacokinetic modeling, x-ray dose and general safety considerations, the basic concepts of perfusion, the methods of acquiring perfusion data, models and formulas to compute relevant perfusion parameters, protocols and how to make studies comparable, patient setup, and more. Contains " pearls" and clinical summaries throughout , helping you quickly grasp the most important points of each topic. Places complex technical and mathematical material in separate boxes which can be referred to as needed. Offers a basis for understanding potential future applications in the management of oncologic, cerebral, renal, pulmonary, and cardiac pathologies. Now with the print edition, enjoy the bundled interactive eBook edition, which can be downloaded to your tablet and smartphone or accessed online and includes features like: Complete content with enhanced navigation Powerful search tools and smart navigation cross-links that pull results from content in the book, your notes, and even the web Cross-linked pages, references, and more for easy navigation Highlighting tool for easier reference of key content throughout the text Ability to take and share notes with friends and colleagues Quick reference tabbing to save your favorite content for future use
This book constitutes the refereed proceedings of the First Joint
Conference; Computer Vision, Virtual Reality and Robotics in
Medicine, CVRMed, and Medical Robotics and Computer-Assisted
Surgery, MRCAS, held in Grenoble, France, in March 1997.
The most salient feature of the infor- last four chapters of the book evaluate the mation provided by nuclear medicine is its information from an analytical and pathophysiological and functional charac- statistical point of view. This approach is ter. For adequate experimental or clinical required for correct decision-making. interpretation, such information should This book is therefore the result of necessarily be interpreted alongside the accumulated experience in nuclear cardiology views of the clinical cardiologist, who is with the invaluable cooperation of medical able to apply it to the individual patient. statisticians. It is directed to physicians This approach, which is routine in every- with an interest in nuclear cardiology, to day clinical practice, reaches its plenitude nuclear medicine specialists wishing to when the whole process is completed and learn the uses and limitations of these an intimate cooperation is established procedures in everyday clinical cardiology, between the nuclear medicine specialist and to cardiologists who feel the need to and the clinical cardiologist. In such understand the rationale and methodology instances, each one of these professionals of the studies which benefit their patients. understands the needs, limits and possi- We understand that the ultimate reason bilities of the other. for any scientific book is the transmission The present book is the fruit of such of knowledge, and we are fully conscious cooperation. In our hospital, an efficient of the enthusiasm of the authors of the nuclear cardiology team has been made up present text to achieve that aim.
The textbook begins with exercises related to radioactive sources and decay schemes. The problems covered include series decay and how to determine the frequency and energy of emitted particles in disintegrations. The next chapter deals with the interaction of ionizing radiation, including the treatment of photons and charged particles. The main focus is on applications based on the knowledge of interaction, to be used in subsequent work and courses. The textbook then examines detectors and measurements, including both counting statistics and properties of pulse detectors. The chapter that follows is dedicated to dosimetry, which is a major subject in medical radiation physics. It covers theoretical applications, such as different equilibrium situations and cavity theories, as well as experimental dosimetry, including ionization chambers and solid state and liquid dosimeters. A shorter chapter deals with radiobiology, where different cell survival models are considered. The last chapter concerns radiation protection and health physics. Both radioecology and radiation shielding calculations are covered. The textbook includes tables to simplify the solutions of the exercises, but the reader is mainly referred to important websites for importing necessary data.
Quantitative coronary angiography has become an invaluable tool for the interventional cardiologist, providing objective and reproducible measurements of coronary artery dimensions, which can be used to study progression or regression of coronary atherosclerosis, as well as the immediate and long term effects of percutaneous interventions. Until recently, this powerful imaging technology was confined to a small number of so-called high level institutions. Fortunately, with the development of digital cardiac imaging equipment and adaptation of cine-angiographically based computer software for on-line use in the catheterization room, quantitative coronary angiography is now available to all interventionalists. This book is a timely guide for the impending QCA user, providing practical as well as theoretical and scientific information. A comprehensive evaluation of the clinical usefulness of QCA is covered, from the fundamental principles through experimental validation studies, application to clinical trials of a wide range of pharmacological and interventional therapies in the full spectrum of clinical presentation of coronary disease syndromes, evaluation of the therapeutic efficacy of various new devices for coronary intervention, together with extensive presentation of its physiological, functional and anatomical correlations, by comparison with other intracoronary measurement and imaging techniques. In addition, evolving theories and concepts in the ever topical restenosis phenomenon' after percutaneous intervention, based on serial QCA studies, are presented and discussed and a potentially unifying methodological approach to further study of this ubiquitous problem is offered. Thisbook, thanks to the collaboration of many experts in the field of intracoronary imaging and measurement, provides stimulating, interesting and practical information, both for the academic scientist and practising clinician.
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