Characterisation and Design of Tissue Scaffolds offers scientists a useful guide on the characterization of tissue scaffolds, detailing what needs to be measured and why, how such measurements can be made, and addressing industrially important issues. Part one provides readers with information on the fundamental considerations in the characterization of tissue scaffolds, while other sections detail how to prepare tissue scaffolds, discuss techniques in characterization, and present practical considerations for manufacturers.

Guide to Cell Therapy GxP is a practical guide to the implementation of quality assurance systems for the successful performance of all cell-based clinical trials. The book covers all information that needs to be included in investigational medicinal product dossier (IMPD), the launching point for any clinical investigation, and beyond. Guide to Cell Therapy GxP bridges a knowledge gap with the inclusion of examples of design of GLP-compliant preclinical studies; design of bioprocesses for autologous/allogeneic therapies; and instruction on how to implement GLP/GMP standards in centers accredited with other quality assurance standards. Guide to Cell Therapy GxP is an essential resource for scientists and researchers in hospitals, transfusion centers, tissue banks, and other research institutes who may not be familiar with the good scientific practice regulations that were originally designed for product development in corporate environments. This book is also a thorough resource for PhD students, Post-docs, Principal Investigators, Quality Assurance Units, and Government Inspectors who want to learn more about how quality standards are implemented in public institutions developing cell-based products.

Biomineralization is a natural process by which living organisms form minerals in association with organic biostructures to form hybrid biological materials such as bone, enamel, dentine and nacre among others. Scientists have researched the fundamentals of these processes and the unique structures and properties of the resulting mineralized tissues. Inspired by them, new biomaterials for tissue engineering and regenerative medicine have been developed in recent years. Biomineralization and biomaterials: fundamentals and applications looks at the characteristics of these essential processes and natural materials and describes strategies and technologies to biomimetically design and produce biomaterials with improved biological performance.

First handbook in the market to cover regulatory affairs in Asia. This handbook covers medical device regulatory systems in different countries, ISO standards for medical devices, clinical trial and regulatory requirements, and documentation for application. Experts from influential international regulatory bodies have contributed to the book.

Nanotechnology-Enhanced Orthopedic Materials provides the latest information on the emergence and rapid development of nanotechnology and the ways it has impacted almost every aspect of biomedical engineering. This book provides readers with a comprehensive overview of the field, focusing on the fabrication and applications of these materials, presenting updated, practical, and systematic knowledge on the synthesis, processing, and modification of nanomaterials, along with the rationale and methodology of applying such materials for orthopedic purposes. Topics covered include a wide range of orthopedic material formulations, such as ceramics, metals, polymers, biomolecules, and self-assemblies. Final sections explore applications and future trends in nanotechnology-enhanced orthopedic materials.

Bioengineering is the application of engineering principles to address challenges in the fields of biology and medicine encompassing the principles of engineering design to the full spectrum of living systems. In surgery, recent advances in minimal invasive surgery and robotics are the culmination of the work that both engineers and surgeons have achieved in the medical field through an exciting and challenging interface. This interface rests on the medical curiosity and engineering solutions that lead eventually to collaboration and development of new ideas and technologies. Most recently, innovation by surgeons has become a fundamental contribution to medical research in the surgical field, and it is through effective communication between surgeons and biomedical engineers and promoting collaborative initiatives that translational research is possible. Bioengineering for Surgery explores this interface between surgeons and engineers and how it leads to innovation processes, providing clinical results, fundraising and prestige for the academic institution. This book is designed to teach students how engineers can fit in with their intended environment and what type of materials and design considerations must be taken into account in regards to medical ideas.

Principles of Measurement and Transduction of Biomedical Variables is a comprehensive text on Biomedical Transducers covering principles of functioning, application examples and new technology solutions. It presents measurement methods of biomedical variables and their transduction to an electrical variable such as voltage. This can then be more easily quantified, processed and visualized as numerical values and graphics; for instance, in a video monitor or liquid crystal display. A different type of transducer is presented in every chapter, such as the functioning principle, transducer block diagram, modeling equations and basic applications in biomedical engineering.
It shows technical and theoretical principles to measure biomedical variables as arterial blood pressure, blood flow, temperature and CO2 concentration in exhaled air. Coverage of these principles will enable you to know how to construct main type of transducers with biomedical applications. Prof. Button s book brings together universal concepts and current technical information on how sensors and transducers function which makes this book an ideal resource for teaching measurement and transduction of biomedical variables in undergraduate and postgraduate Biomedical Engineering programs.
Learn how to design transducers through practical examples and applied informationCovers MEMS and laser sensorsGet an overview of the range of devices and techniques available plus advantages and shortcomings for each transducer type"

Analytical Ultracentrifugation, the latest volume in Methods in Enzymology, focuses on analytical ultracentrifugation. The scope of this technique has greatly expanded in recent years due to advances in instrumentation, algorithms and software. This volume describes the latest innovations in the field and in the applications of analytical ultracentrifugation in the analysis of macromolecules, macromolecular assemblies, and biopharmaceuticals.

Biophotonics for Medical Applications presents information on the interface between laser optics and cell biology/medicine. The book discusses the development and application of photonic techniques that aid the diagnosis and therapeutics of biological tissues in both healthy and diseased states. Chapters cover the fundamental technologies used in biophotonics and a wide range of therapeutic and diagnostic applications.

Functional Marine Biomaterials: Properties and Applications provides readers with the latest information on the diverse marine environment as a resource for many new substances, including biopolymers, bioceramics, and biominerals. As recent advances and funding has enabled scientists to begin harnessing many of these materials for biomedical applications from drug delivery to bone tissue engineering and biosensors, this important new text provides readers with a comprehensive review of these materials and their functional applications in the biomedical field. Chapters discuss the properties of the main classes of functional marine biomaterials, applications of marine products in tissue engineering, applications in drug delivery systems, and the role of marine derived materials in medical devices.

Hydroxyapatite in the form of hydroxycarbonate apatite is the principal mineral component of bone tissue in mammals. In Bioceramics, it is classed as a bioactive material, which means bone tissue grows directly on it when placed in apposition without intervening fibrous tissue. Hydroxyapatite is hence commonly used as bone grafts, fillers and as coatings for metal implants. This important book provides an overview of the most recent research and developments involving hydroxyapatite as a key material in medicine and its application.

Innovation in areas such as power supplies, size reduction, biocompatibility, durability and lifespan is leading to a rapid increase in the range of devices and applications in the field of implantable biomedical microsystems, which are used for monitoring, diagnosing, and controlling the activities of the human body.

This book provides comprehensive coverage of the fundamental design principles for implantable systems, as well as several major application areas. Each component in an implantable system is described, and major case studies demonstrate how these systems can be designed and optimized for specific design objectives.

Beside low-power signal processing electronics for implantable systems, further topics covered include signal processing hardware, sensor selection, wireless telemetry devices, new types of bio-transducers, power management solutions, system integration techniques, computational algorithms, device packaging, and security measures.

Case studies include studies on implantable neural signal processors, brain-machine interface (BMI) systems, implantable pressure sensors, pacemakers, neural prosthesis, cochlear implant systems, bladder pressure monitoring for treating urinary incontinence, and drug delivery for cancer patients.

Implantable Biomedical Microsystems is the first comprehensive coverage of bioimplantable system design providing an invaluable information source for researchers in Biomedical, Electrical, Computer, Systems, and Mechanical Engineering as well as Engineers involved in design and development of implantable electronic systems and, more generally, Engineers working on low-power wireless applications.
First time comprehensive coverage of system-level and component-level design and engineering aspects for implantable microsystems.
Provides insight into a wide range of proven applications and application specific design trade-offs of bioimplantable systems, including several major case studies.
Enables Engineers involved in development of implantable electronic systems to optimize applications for specific design objectives."

Despite advances in alternative materials, metals are still the biomaterial of choice for a number of clinical applications such as dental, orthopedic and cardiac implants. However, there are a number of intrinsic problems associated with implanting metal in the biological environment, such as wear, corrosion, biocompatibility and toxicity, which must be addressed. Modern technology has enabled scientists to modify metal surfaces or apply special coatings to metals to improve their performance safety. Surface Coating and Modification of Metallic Biomaterials will discuss the most important modification techniques and coatings for metals, first covering the fundamentals of metals as a biomaterial and then exploring surface modification techniques and coatings.

Shape memory polymers (SMPs) are an emerging class of smart polymers which give scientists the ability to process the material into a permanent state and predefine a second temporary state which can be triggered by different stimuli. The changing chemistries of SMPs allows scientists to tailor important properties such as strength, stiffness, elasticity and expansion rate. Consequently SMPs are being increasingly used and developed for minimally invasive applications where the material can expand and develop post insertion. This book will provide readers with a comprehensive review of shape memory polymer technologies. Part 1 will discuss the fundamentals and mechanical aspects of SMPs. Chapters in part 2 will look at the range of technologies and materials available for scientific manipulation whilst the final set of chapters will review applications.

Chitosan in Biomedical Applications provides a thorough insight into the complete chitosan chemistry, collection, chemical modifications, characterization and applications of chitosan in biomedical applications and healthcare fields. Chitosan, a biopolymer of natural origin, has been explored for its variety of applications in biomedical research, medical diagnostic aids and material science. It is the second most abundant natural biopolymer after cellulose, and considered as an excellent excipient because of its non-toxic, stable, biodegradable properties. Several research innovations have been made on applications of chitosan in biomedical applications. The book explores key topics, such as molecular weight, degree of deacetylation, and molecular geometry, along with an emphasis on recent advances in the field written by academic, industry, and clinical researchers. Chitosan in Biomedical Applications will be of interest to those in biomedical fields including the biomaterials and tissue engineering community investigating and developing biomaterials for biomedical applications, particularly graduate students, young faculty and others exploring chitosan-based materials.

Repair and regeneration of musculoskeletal tissues is generating substantial interest within the biomedical community. Consequently, these are the most researched tissues from the regeneration point of view. Regenerative Engineering of Musculoskeletal Tissues and Interfaces presents information on the fundamentals, progress and recent developments related to the repair and regeneration of musculoskeletal tissues and interfaces. This comprehensive review looks at individual tissues as well as tissue interfaces. Early chapters cover various fundamentals of biomaterials and scaffolds, types of cells, growth factors, and mechanical forces, moving on to discuss tissue-engineering strategies for bone, tendon, ligament, cartilage, meniscus, and muscle, as well as progress and advances in tissue vascularization and nerve innervation of the individual tissues. Final chapters present information on musculoskeletal tissue interfaces.

Research and developments in neuroprostheses are providing scientists with the potential to greatly improve the lives of individuals who have lost some function. Neuroprostheses can help restore or substitute motor and sensory functions which may have been damaged as a result of injury or disease. However, these minute implantable sensors also provide scientists with challenges. This important new book provides readers with a comprehensive review of neuroprostheses. Chapters in part one are concerned with the fundamentals of these devices. Part two looks at neuroprostheses for restoring sensory function whilst part three addresses neuroprostheses for restoring motor function. The final set of chapters discusses significant considerations concerning these sensors.

Nanoparticle therapeutics: Production Technologies, Types of Nanoparticles, and Regulatory Aspects employs unique principles for applications in cell-based therapeutics, diagnostics and mechanistics for the study of organ physiology, disease etiology and drug screening of advanced nanoparticles and nanomaterials. The book focuses on the extrapolation of bioengineering tools in the domain of nanotechnology and nanoparticles therapeutics, fabrication, characterization and drug delivery aspects. It acquaints scientists and researchers on the experiential and experimental aspects of nanoparticles and nanotechnology to equip their rational application in various fields, especially in differential diagnoses and in the treatment of diverse diseased states. This complete resource provides a holistic understanding of the principle behind formation, characterization, applications, regulations and toxicity of nanoparticles employing myriad principles of nanotechnology. Investigators, pharmaceutical researchers, and advanced students working on technology advancement in the areas of designing targeted therapies, nanoscale imaging systems and diagnostic modalities in human diseases where nanoparticles can be used as a critical tool for technology advancement in drug delivery systems will find this book useful.

Surface modification of magnesium and its alloys for biomedical applications: Biological interactions, mechanical properties and testing, the first of two volumes, is an essential guide on the use of magnesium as a degradable implant material. Due to their excellent biocompatibility and biodegradability, magnesium based degradable implants provide a viable option for the permanent metallic implants. This volume focuses on the fundamental concepts of surface modification of magnesium, its biological interactions, mechanical properties and, in vitro and in vivo testing. The contents of volume 1 is organized and presented in three parts. Part 1 reviews the fundamental aspects of surface modification of magnesium, including surface design, opportunities, challenges and its role in revolutionizing biodegradable biomaterials. Part 2 addresses the biological and mechanical properties covering an in vivo approach to the bioabsorbable behavior of magnesium alloys, mechanical integrity and, the effects of amino acids and proteins on the performance of surface modified magnesium. Part 3 delves in to testing and characterization, exploring the biocompatibility and effects on fatigue life alongside the primary characteristics of surface modified magnesium. All chapters are written by experts, this two volume series provides systematic and thorough coverage of all major modification technologies and coating types of magnesium and its alloys for biomedical applications.

The Case Studies in Medical Devices Design series consists of practical, applied case studies relating to medical device design in industry. These titles complement Ogrodnik's Medical Device Design and will assist engineers with applying the theory in practice. The case studies presented directly relate to Class I, Class IIa, Class IIb and Class III medical devices. Designers and companies who wish to extend their knowledge in a specific discipline related to their respective class of operation will find any or all of these titles a great addition to their library. Class 1 Devices is a companion text to Medical Devices Design: Innovation from Concept to Market. The intention of this book, and its sister books in the series, is to support the concepts presented in Medical Devices Design through case studies. In the context of this book the case studies consider Class I (EU) and 510(k) exempt (FDA) . This book covers classifications, the conceptual and embodiment phase, plus design from idea to PDS.

Are we satisfied with the rate of drug development? Are we happy with the drugs that come to market? Are we getting our money's worth in spending for basic biomedical research? In Translational Systems Biology, Drs. Yoram Vodovotz and Gary An address these questions by providing a foundational description the barriers facing biomedical research today and the immediate future, and how these barriers could be overcome through the adoption of a robust and scalable approach that will form the underpinning of biomedical research for the future. By using a combination of essays providing the intellectual basis of the Translational Dilemma and reports of examples in the study of inflammation, the content of Translational Systems Biology will remain relevant as technology and knowledge advances bring broad translational applicability to other diseases. Translational systems biology is an integrated, multi-scale, evidence-based approach that combines laboratory, clinical and computational methods with an explicit goal of developing effective means of control of biological processes for improving human health and rapid clinical application. This comprehensive approach to date has been utilized for in silico studies of sepsis, trauma, hemorrhage, and traumatic brain injury, acute liver failure, wound healing, and inflammation.

Neuroprosthetics is a fast-growing area that brings together the fields of biomedical engineering and neuroscience as a means to interface the neural system directly to prostheses. Advancing research and applications in this field can assist in successfully restoring motor, sensory, and cognitive functions. Emerging Theory and Practice in Neuroprosthetics brings together the most up-to-date research surrounding neuroprosthetics advances and applications. Presenting several new results, concepts, and further developments in the area of neuroprosthetics, this book is an essential publication for researchers, upper-level students, engineers, and medical practitioners.

The use of bioresorbable polymers in stents, fixation devices and tissue engineering is revolutionising medicine. Both industry and academic researchers are interested in using computer modelling to replace some experiments which are costly and time consuming. This book provides readers with a comprehensive review of modelling polymers and polymeric medical devices as an alternative to practical experiments. Chapters in part one provide readers with an overview of the fundamentals of biodegradation. Part two looks at a wide range of degradation theories for bioresorbable polymers and devices. The final set of chapters look at advances in modelling biodegradation of bioresorbable polymers. This book is an essential guide to those concerned with replacing tests and experiments with modelling.

Total hip arthroplasty, the most commonly performed orthopedic procedure, is used to replace or reconstruct the hip with an artificial joint. "Perspectives in Total Hip Arthroplasty" outlines developments in technologies and biomaterials used for this procedure, with a focus on the tribological interactions of the materials used.

Part one outlines the history of total hip arthroplasty and goes on to explore advances in techniques and biomaterials. Part two focuses on the tribology of materials used to perform this procedure, explaining the impact of wear on the load-bearing surface, a major cause of failure in hip prostheses. Chapters review a range of materials, including modern biomaterials, hybrid materials, metal, ceramic, and polyethylene. The book also discusses the tribological interactions of these materials when used in total hip arthroplasty.

"Perspectives in Total Hip Arthroplasty "is a key resource for clinicians, researchers, and academics interested in the tribology of total hip arthroplasty, as well as materials researchers, engineers, and academics concerned with the tribology of biomaterials.
Covers techniques from innovative surgeons and designs from multinational manufacturers, as well as information on improvements in technologies and biomaterialsDiscusses the tribology of all the major materials used in total hip arthroplasty