Comprises four parts, the first of which provides an overview of the topics that are developed from fundamental principles to more advanced levels in the other parts. Presents in the second part an in-depth introduction to the relevant background in molecular and cellular biology and in physical chemistry, which should be particularly useful for students without a formal background in these subjects. Provides in the third part a detailed treatment of microscopy techniques and optics, again starting from basic principles. Introduces in the fourth part modern statistical approaches to the determination of parameters of interest from microscopy data, in particular data generated by single molecule microscopy experiments. Uses two topics related to protein trafficking (transferrin trafficking and FcRn-mediated antibody trafficking) throughout the text to motivate and illustrate microscopy techniques

The book fills a void as a textbook with hands-on laboratory exercises designed for biomedical engineering undergraduates in their senior year or the first year of graduate studies specializing in electrical aspects of bioinstrumentation. Each laboratory exercise concentrates on measuring a biophysical or biomedical entity, such as force, blood pressure, temperature, heart rate, respiratory rate, etc., and guides students though all the way from sensor level to data acquisition and analysis on the computer. The book distinguishes itself from others by providing electrical circuits and other measurement setups that have been tested by the authors while teaching undergraduate classes at their home institute over many years. Key Features: * Hands-on laboratory exercises on measurements of biophysical and biomedical variables * Each laboratory exercise is complete by itself and they can be covered in any sequence desired by the instructor during the semester * Electronic equipment and supplies required are typical for biomedical engineering departments * Data collected by undergraduate students and data analysis results are provided as samples * Additional information and references are included for preparing a report or further reading at the end of each chapter Students using this book are expected to have basic knowledge of electrical circuits and troubleshooting. Practical information on circuit components, basic laboratory equipment, and circuit troubleshooting is also provided in the first chapter of the book.

Mild traumatic brain injury (mTBI), directly related to chronic traumatic encephalopathy, presents a crisis in contact sports, the military, and public health. Mild Traumatic Brain Injury: A Science and Engineering Perspective reviews current understanding of mTBI, methods of diagnosis, treatment, policy concerns, and emerging technologies. It details the neurophysiology and epidemiology of brain injuries by presenting disease models and descriptions of nucleating events, characterizes sensors, imagers, and related diagnostic measures used for evaluating and identifying brain injuries, and relates emerging bioinformatics analysis with mTBI markers. The book goes on to discuss issues with sports medicine and military issues; covers therapeutic strategies, surgeries, and future developments; and finally addresses drug trials and candidates for therapy. The broad coverage and accessible discussions will appeal to professionals in diverse fields related to mTBI, students of neurology, medicine, and biology, as well as policy makers and lay persons interested in this hot topic. Features Summarizes the entire scope of the field of mTBI Details the neurophysiology, epidemiology, and presents disease models and descriptions of nucleating events Characterizes sensors, imagers, and related diagnostic measures and relates emerging bioinformatics analysis with mTBI markers Discusses issues with sports medicine and military issues Covers therapeutic strategies, surgeries, and future developments and addresses drug trials and candidates Dr Mark Mentzer earned his PhD in Electrical Engineering from the University of Delaware. He is a former research scientist at the US Army Research Laboratory where he studied mild traumatic brain injury and developed early-detection brain injury helmet sensors. He is a certified test director and contracting officer representative. He possesses two Level-III Defense Acquisition University Certifications in Science and Technology Management and in Test and Evaluation. During his career, he developed a wide range of sensors and instrumentation as well as biochemical processes to assess brain trauma. Mentzer currently teaches graduate systems engineering and computer science courses at the University of Maryland University College.

For more than a decade, the focus of information technology has been on capturing and sharing data from a patient within an all-encompassing record (a.k.a. the electronic health record, EHR), to promote improved longitudinal oversight in the care of the patient. There are both those who agree and those who disagree as to whether this goal has been met, but it is certainly evolving. A key element to improved patient care has been the automated capture of data from durable medical devices that are the source of (mostly) objective data, from imagery to time-series histories of vital signs and spot-assessments of patients. The capture and use of these data to support clinical workflows have been written about and thoroughly debated. Yet, the use of these data for clinical guidance has been the subject of various papers published in respected medical journals, but without a coherent focus on the general subject of the clinically actionable benefits of objective medical device data for clinical decision-making purposes. Hence, the uniqueness of this book is in providing a single point-of-capture for the targeted clinical benefits of medical device data--both electronic- health-record-based and real-time--for improved clinical decision-making at the point of care, and for the use of these data to address and assess specific types of clinical surveillance. Clinical Surveillance: The Actionable Benefits of Objective Medical Device Data for Crucial Decision-Making focuses on the use of objective, continuously collected medical device data for the purpose of identifying patient deterioration, with a primary focus on those data normally obtained from both the higher-acuity care settings in intensive care units and the lower-acuity settings of general care wards. It includes examples of conditions that demonstrate earlier signs of deterioration including systemic inflammatory response syndrome, opioid-induced respiratory depression, shock induced by systemic failure, and more. The book provides education on how to use these data, such as for clinical interventions, in order to identify examples of how to guide care using automated durable medical device data from higher- and lower-acuity care settings. The book also includes real-world examples of applications that are of high value to clinical end-users and health systems.

For more than a decade, the focus of information technology has been on capturing and sharing data from a patient within an all-encompassing record (a.k.a. the electronic health record, EHR), to promote improved longitudinal oversight in the care of the patient. There are both those who agree and those who disagree as to whether this goal has been met, but it is certainly evolving. A key element to improved patient care has been the automated capture of data from durable medical devices that are the source of (mostly) objective data, from imagery to time-series histories of vital signs and spot-assessments of patients. The capture and use of these data to support clinical workflows have been written about and thoroughly debated. Yet, the use of these data for clinical guidance has been the subject of various papers published in respected medical journals, but without a coherent focus on the general subject of the clinically actionable benefits of objective medical device data for clinical decision-making purposes. Hence, the uniqueness of this book is in providing a single point-of-capture for the targeted clinical benefits of medical device data--both electronic- health-record-based and real-time--for improved clinical decision-making at the point of care, and for the use of these data to address and assess specific types of clinical surveillance. Clinical Surveillance: The Actionable Benefits of Objective Medical Device Data for Crucial Decision-Making focuses on the use of objective, continuously collected medical device data for the purpose of identifying patient deterioration, with a primary focus on those data normally obtained from both the higher-acuity care settings in intensive care units and the lower-acuity settings of general care wards. It includes examples of conditions that demonstrate earlier signs of deterioration including systemic inflammatory response syndrome, opioid-induced respiratory depression, shock induced by systemic failure, and more. The book provides education on how to use these data, such as for clinical interventions, in order to identify examples of how to guide care using automated durable medical device data from higher- and lower-acuity care settings. The book also includes real-world examples of applications that are of high value to clinical end-users and health systems.

Gives a comprehensive view on the nanomaterials used in plasmonic optical fiber biosensors Includes synthesis, characterization, and usage for detection of different analytes Discusses trends in the design of wavelength-based optical fiber sensors Reviews micro- and nanostructured biosensing devices Explores application of plasmonic sensors in the biosensing field

In 2019 the world was struck with the Coronavirus (COVID-19) infecting major portions of the world's population. There were no vaccines or treatments available to help mitigate the disease or offer a cure. The world's health systems were inundated with massive numbers of patients with varying ranges of symptoms, acuity, and levels of criticality. The world's healthcare organizations soon found themselves in an unmanageable situation, directly impacting the ability to manage patients across the entire healthcare environment. Most healthcare institutions had plans for emergency preparedness and procedures to deal with temporary crises, none of which were effective against the impact of COVID-19. COVID-19 was a highly contagious disease, resulting in high volumes of admissions with long lengths of stay. The virus quickly overwhelmed institutions with large patient volumes, resulting in shortages of patient beds, medical equipment, personal protective devices, cleaning agents, and other critical supplies. Hospital operations were further impacted by staff shortages due to exposure, resulting contagion, the shutdown of transit systems, and responsibilities at home due to school and business closures. This timely and important book describes the impact on the hospital ability to provide patient care and how healthcare institutions leveraged diverse technology solutions to combat the impact of COVID-19 on providing patient care. The authors also discuss implementation of these technology solutions and the many lessons learned of how healthcare institutions can enhance their emergency preparedness in the future from the COVID experience. The authors would like to acknowledge, thank, and dedicate this book to the hundreds of thousands of healthcare workers around the world who spent countless hours and put their own lives and families lives at risk to help patients though this pandemic.

In today's world, the use of technology is growing rapidly, and people need effective solutions for their real-life problems. This book discusses smart applications of associated technologies to develop cohesive and comprehensive solutions for the betterment of humankind. It comprehensively covers the effective use of the Internet of Things (IoT), wireless sensor network, wearable sensors, body area network, cloud computing, and distributed computing methodologies. The book comprehensively covers IoT and fog computing sensor supported technologies or protocols including web of things, near-field communication, 6LoWPAN, LoRAWAN, XMPP, DDS, LwM2M, Mesh Protocol, and radio-frequency identification. The book- Discusses smart applications to develop cohesive and comprehensive solutions for real-life problems. Covers analytical descriptions with appropriate simulation and prototype models. Examines the role of IoT and fog computing technologies during global emergency situations. Discusses key technologies including cloud computing, 5G communication, big data, artificial intelligence, control systems, and wearable sensors. The text is primarily written for graduate students, and academic researchers working in diverse fields of electrical engineering, biomedical engineering, electronics and communication engineering, computer engineering, and information technology.

Provides academic introduction to the uses of nanotechnology in drug delivery Discusses use of nanomaterials in targeting a drug to specific tissues and cells Presents an analysis of clinical status for different types of Nano platforms Covers applications in drug delivery, therapy, and engineering Focus on how novel nanotechnology orientated methods can help improve treatment

Covers synthesis, properties and applications of quantum dots Discusses the modern fabrication technologies, processing, nanostructure formation, and mechanisms of reinforcement of quantum dots-polymer nanocomposites Explores the properties of quantum dots-based polymer nanocomposites Discusses the biocompatibility, suitability, and toxic effects of quantum dots-based polymer nanocomposites Reviews recent innovations, applications, opportunities, and future directions in quantum dots-based polymer nanocomposites

Provides a platform related to fabrication and advancement of all categories of polymeric biomaterials Explores advancement of pertinent biomedical and drug delivery systems Includes a wide range of biomaterials and its application in diversified fields Gives out environmental justification of green biopolymers and their applications in water remediation Discusses advanced applications of bio-composite polymers viz. food packaging and anti-corrosive coatings

Discusses the topological charge of an optical vortex is equal to the number of screw dislocations or the number of phase singularities in the beam cross-section Presents a single approach based on the M. Berry formula Describes the topological competition between different optical vortices in a superposition Demonstrates the stability of the topological charge to random phase distortions and insensitivity to amplitude distortions Contains many numerical examples, which clearly show how the phase of optical vortices changes during propagation in free space and the topological charge is preserved

Linear induction accelerators are successfully used as power supplies for numerous devices of relativistic high-frequency electronics. This book addresses ways to solve physical and engineering problems arising in the calculation, design, modeling and operation of linear induction accelerators intended for supplying relativistic microwave devices. It reviews and analyzes both classic and recent studies on the topic of linear induction accelerators (LIA) for generating and amplifying microwave radiation by relativistic devices.

The first book of its kind to highlight the unique capabilities of laser-driven acceleration and its diverse potential, Applications of Laser-Driven Particle Acceleration presents the basic understanding of acceleration concepts and envisioned prospects for selected applications. As the main focus, this new book explores exciting and diverse application possibilities, with emphasis on those uniquely enabled by the laser driver that can also be meaningful and realistic for potential users. It also emphasises distinction, in the accelerator context, between laser-driven accelerated particle sources and the integrated laser-driven particle accelerator system (all-optical and hybrid versions). A key aim of the book is to inform multiple, interdisciplinary research communities of the new possibilities available and to inspire them to engage with laser-driven acceleration, further motivating and advancing this developing field. Material is presented in a thorough yet accessible manner, making it a valuable reference text for general scientific and engineering researchers who are not necessarily subject matter experts. Applications of Laser-Driven Particle Acceleration is edited by Professors Paul R. Bolton, Katia Parodi, and Joerg Schreiber from the Department of Medical Physics at the Ludwig-Maximilians-Universitat Munchen in Munchen, Germany. Features: Reviews the current understanding and state-of-the-art capabilities of laser-driven particle acceleration and associated energetic photon and neutron generation Presents the intrinsically unique features of laser-driven acceleration and particle bunch yields Edited by internationally renowned researchers, with chapter contributions from global experts

The mechanics underlying the form and structure of biological tissues is being increasingly investigated and appreciated, with new results appearing at a fast pace. Cellular Patterns covers the salient elements of this thriving field of research in a textbook style, including both historic landmark results and recent achievements. By building on concepts such as packing, confinement, surface tension, and elastic instabilities, the book explains the structure and the shape of sheet-like and bulk tissues by adapting the mechanics of continuous media to living matter. It reviews experimental results and empirical laws, and wherever possible, it discusses more than a single theoretical interpretation of a given phenomenon. The in-depth treatment of technical details, the many boxes summarizing essential physical and biological ideas, and an extensive set of problems make this book suitable as a complementary textbook for a graduate course in biophysics and as a standalone reference for students and researchers in biophysics, bioengineering, and mathematical biology interested in the mechanics of tissue. Features: Provides an overview of patterns and shapes seen in animal tissues in addition to an interpretation of these structures in terms of physical forces and processes Contains detailed analysis and a critical comparison of mechanical models of cells, tissues, and morphogenetic movements Presents a visually rich style which is accessible to physicists and biologists alike

Book initiates with introductory material to hemodialysis technology and its historical evolution and later on divulging into the field of biomaterials. With this background, the book discusses selection criteria of a suitable biomaterial for synthesis of haemodialysis membranes along with illustration of a complete indigenous, low cost technology for spinning of haemodialysis fibres. Well illustrated description of instruments used for membrane characterization and biomedical engineering is also provided at suitable junctures to effectively present the concept including worked out examples. Present title can be a good textbook as well as a research material for membrane as well as biomedical engineering curricula and provides coverage for appropriate undergraduate and graduate students interested in hemodialysis membranes.

. Despite their capacity to carry out functions that previously were unobtainable, smart polymers and hydrogels tend to have painfully slow response times. On the other hand biological systems go through phase changes at an extremely fast rate. Reflexive Polymers and Hydrogels examines the natural systems that respond almost instantaneously to environmental stimuli, and thus gives the reader an understanding of the mechanisms that govern these responses. The book includes chapters on approaches and procedures for designing a synthetic ...flash... system based on naturally occurring systems. It also deals with some of the promising potential applications of flash systems in industry.

Presents exclusive material on integration of 4D imaging and 4D printing Demonstrates the industrial applications of 4D imaging in 4D printing using multiple case studies Discusses use of open source 4D imaging tools for biomedical applications Includes in-house development of smart materials for 4D printing Reviews low cost, indigenous lab scale solutions for various veterinary applications

Provides detailed introduction to Internet of Healthcare Things (IoHT) and its applications Reviews underlying sensor and hardware technologies Includes recent advances in the IoHT such as remote healthcare monitoring and wearable devices Explores applications of Data Analytics/Data Mining in IoHT, including data management and data governance Focusses on regulatory and compliance issues in IoHT

Composites in Biomedical Applications presents a comprehensive overview on recent developments in composites and their use in biomedical applications. It features cutting-edge developments to encourage further advances in the field of composite research. Highlights a completely new research theme in polymer-based composite materials Outlines a broad range of different research fields, including polymer and natural fiber reinforcement used in the development of composites for biomedical applications Discusses advanced techniques for the development of composites and biopolymer-based composites Covers fatigue behavior, conceptual design in ergonomics design application, tissue regeneration or replacement, and skeletal bone repair of polymer composites Details the latest developments in synthesis, preparation, characterization, material evaluation, and future challenges of composite applications in the biomedical field This book is a comprehensive resource for advanced students and scientists pursuing research in the broad fields of composite materials, polymers, organic or inorganic hybrid materials, and nano-assembly.

In the fast-developing field of nanomedicine, a broad variety of materials have been used for the development of advanced delivery systems for drugs, genes, and diagnostic agents. With the recent breakthroughs in the field, we are witnessing a new age of disease management, which is governed by precise regulation of dosage and delivery. This book presents the advances in the use of lipid-based and inorganic nanomaterials for medical imaging, diagnosis, theranostics, and drug delivery. The materials discussed include liposome-scaffold systems, elastic liposomes, targeted liposomes, solid lipid nanoparticles, lipoproteins, exosomes, porous inorganic nanomaterials, silica nanoparticles, and inorganic nanohybrids. The book provides all available information about them and describes in detail their advantages and disadvantages and the areas where they could be utilized successfully.

Automata Theory and Formal Languages: Concepts and Practices presents the difficult concepts of automata theory in a straightforward manner, including discussions on diverse concepts and tools that play major roles in developing computing machines, algorithms and code. Automata theory includes numerous concepts such as finite automata, regular grammar, formal languages, context free and context sensitive grammar, push down automata, Turing machine, and decidability, which constitute the backbone of computing machines. This book enables readers to gain sufficient knowledge and experience to construct and solve complex machines. Each chapter begins with key concepts followed by a number of important examples that demonstrate the solution. The book explains concepts and simultaneously helps readers develop an understanding of their application with real-world examples, including application of Context Free Grammars in programming languages and Artificial Intelligence, and cellular automata in biomedical problems.

Environmental stress caused by water continuously exposes buildings to microbial colonization. This is highly evident when both minor dampness and mass flooding occur. The text describes how microbiological corrosion of buildings and the structures and substances derived from these hazards are responsible for adverse health effects on people exposed to these contaminated environments. Microbiological Corrosion of Buildings: A Guide to Detection, Health Hazards, and Mitigation describes the key elements and methods for neutralising and removing microbiological contamination, and the operating algorithm for checking the effectiveness of preventative solutions. Ideal for construction engineers, microbiologists and professionals in the field. Features: Latest methods for detection of indoor microbial hazards Identifies the tools needed for natural, non-destructive and non-invasive methods of bio-corrosion removal Describes the social and health problems associated with exposure to microbiological hazards Provides case studies and examples of microorganisms responsible for microbial corrosion. 'Climate change and the associated adverse effects, such as floods and whirlwinds, make the problem of microbiological corrosion of buildings that generates health risks and economic losses on a global scale, the focus of science and technology. The monograph presents a complex problem of building bio-corrosion, that requires knowledge of the distant fields of microbiology and building technology, for the use of both scientists and practitioners. This pioneering work of an interdisciplinary nature harmoniously combines knowledge on specific microbiological issues relating to the process of bio-corrosion and the associated health risks with detailed issues of construction technology concerning the prevention of bio-corrosion and its removal. The authors succeeded in combining a very high scientific level in the monograph with an accessible and understandable presentation of complex problems. The extensive references, ranging from "classical" items from many years ago to the most recent articles presenting the state of the art in this field, are worth emphasising.' -Prof. Jacek Dutkiewicz, Ph.D., D.Sc., Institute of Rural Health in Lublin

Recent toxicological studies show that nanoparticles released in technological processes and combustion processes outside industry can be dangerous for humans especially when entering the body through the mouth and nose. In connection with the above, the use of adequately effective respiratory protection equipment is of great importance in prophylactic and preventive activities. The first part of Nanoaerosols, Air Filtering and Respiratory Protection: Science and Practice refers to the general phenomena of filtration described on the basis of the authors' own experience and international reports. The book also includes a description of the respiratory system and principles of its functioning and the accumulation of aerosol particles. It goes on to discuss technological innovations regarding the production of filtering materials for protection against nanoparticles and the latest test methods. Finally, the book contains information about the proper selection and use of respiratory protective devices against airborne nanoparticles in the workplace and everyday life. Special attention is paid to proper fit procedures as well as use and maintenance activities of such devices. The content of the book with rich illustrative material has been presented so that it can be used by health and safety experts, students as well as employers, employees and private users of respiratory protective devices. "Through a comprehensive approach to the subject of the work, the authors present theoretical foundations as well as practical solutions that are used in the research and development of personal respiratory protection. The complementarity of the information contained in the book will allow the reader to become familiar with a wide range of knowledge related to the design and manufacture as well as assessment of properties and procedures for the use of respiratory protection against the adverse effects of aerosols, including air contaminated with nanoparticles and microparticles. In my opinion the book is a valuable part of the series Occupational Safety, Health, and Ergonomics: Theory and Practice, published by Taylor & Francis." -Maciej Bogun, LUKASIEWICZ - The Textile Research Institute, Lodz

The need for qualified specialists to work with and apply sophisticated technology in contemporary medicine is rapidly growing. Professional bodies predict that meeting the needs of healthcare globally will require almost tripling the number of Medical Physicists by 2035. Similar challenges exist in the constantly growing profession of Medical Engineering. They can be solved most efficiently and effectively with the tools of e-Learning, and a free and open-source Virtual Learning Environment (VLE) platform such as Moodle is a welcome solution. The Moodle VLE platform is a free, open source learning management system that is the most popular choice for higher educational institutions worldwide. However, the best practices of the Moodle system are still unknown to many. This practical guide provides educators, programme administrators, and programme directors with a condensed guide to Moodle and step-by-step instructions on how to create a single course or an entire educational programme. It also discusses cost-effective ways to apply e-Learning in an educational institution. This guide is accessible to all professionals, even those without specialist IT skills, and will be helpful to educators of all levels in Medical Physics and Engineering, as well as in other medical and medical-related specialties or disciplines with a strong imaging component. Features: Provides step-by-step instructions of how to build a course/module for Higher Education on Moodle Gives practical solutions to implementing e-Learning in Medical Physics and Engineering Explores useful tips and tricks for best practice