This book provides in-depth insights into assembling dynamics of proteins, DNA and other nanoparticles. The applications of basic knowledge in the development of artificial self-assembling systems will be discussed and state of the art methodology in the field will be presented.This interdisciplinary work brings together aspects of different fields of expertise such as Biology, Physics and Material Sciences and is intended for researchers, professors and graduate students interested in the design of self-assembling materials.

This textbook is designed for an introductory course at undergraduate and graduate levels for bioengineering students. It provides a systematic way of examining bioengineering problems in a multidisciplinary computational approach. The book introduces basic concepts of multidiscipline-based computational modeling methods, provides detailed step-by-step techniques to build a model with consideration of underlying multiphysics, and discusses many important aspects of a modeling approach including results interpretation, validation, and assessment.

This book focuses on the systems biomechanics of bone remodeling that provide a multiscale platform for bone adaptation, spanning the cellular, tissue, and organ levels. The mathematical model explained in each section provides concrete examples of in silico approaches for bone adaptation. It will be immensely useful for readers interested in bone morphology and metabolism and will serve as an effective bridge connecting mechanics, cellular and molecular biology, and medical sciences. These in silico approaches towards exploring the mechanisms by which the functioning of dynamic living systems is established and maintained have potential for facilitating the efforts of graduate students and young researchers pioneering new frontiers of biomechanics.

This book on classification in biomedical image applications presents original and valuable research work on advances in this field, which covers the taxonomy of both supervised and unsupervised models, standards, algorithms, applications and challenges. Further, the book highlights recent scientific research on artificial neural networks in biomedical applications, addressing the fundamentals of artificial neural networks, support vector machines and other advanced classifiers, as well as their design and optimization. In addition to exploring recent endeavours in the multidisciplinary domain of sensors, the book introduces readers to basic definitions and features, signal filters and processing, biomedical sensors and automation of biomeasurement systems. The target audience includes researchers and students at engineering and medical schools, researchers and engineers in the biomedical industry, medical doctors and healthcare professionals.

This book covers the properties of biomaterials that have found wide clinical applications, while also reviewing the state-of-the-art in the development towards future medical applications, starting with a brief introduction to the history of biomaterials used in hip arthroplasty. The book then reviews general types of biomaterials - polymers, ceramics, and metals, as well as different material structures such as porous materials and coatings and their applications - before exploring various current research trends, such as biodegradable and porous metals, shape memory alloys, bioactive biomaterials and coatings, and nanometals used in the diagnosis and therapy of cancer. In turn, the book discusses a range of methods and approaches used in connection with biomaterial properties and characterization - chemical properties, biocompatibility, in vivo behaviour characterisation, as well as genotoxicity and mutagenicity - and reviews various diagnostic techniques: histopathological analysis, imagining techniques, and methods for physicochemical and spectroscopic characterization. Properties of stent deployment procedures in cardiovascular surgeries, from aspects of prediction, development and deployment of stent geometries are presented on the basis of novel modelling approaches. The last part of the book presents the clinical applications of biomaterials, together with case studies in dentistry, knee and hip prosthesis. Reflecting the efforts of a multidisciplinary team of authors, gathering chemical engineers, medical doctors, physicists and engineers, it presents a rich blend of perspectives on the application of biomaterials in clinical practice. The book will provide clinicians with an essential review of currently available solutions in specific medical areas, also incorporating non-medical solutions and standpoints, thus offering them a broader selection of materials and implantable solutions. This work is the result of joint efforts of various academic and research institutions participating in WIMB Tempus project, 543898-TEMPUS-1-2013-1-ES-TEMPUS-JPHES, "Development of Sustainable Interrelations between Education, Research and Innovation at WBC Universities in Nanotechnologies and Advanced Materials where Innovation Means Business", co-funded by the Tempus Programme of the European Union.

This book discusses the importance of oxidative stress, related biomarkers, and its diagnostic methods including bio-analytical and advanced detection systems. Oxidative stress is associated with diminished capacity of a biological system to overcome the overproduction of reactive oxygen species. Since oxidative stress has been suggested as a causative factor in many diseases, its prevention is vital, and there is an urgent need for oxidative stress monitoring using in vitro and in vivo models. Interdisciplinary approaches have lead to the development of various oxidative stress monitoring models for real-world clinical and biomedical applications. The development of such methods requires a broad understanding of biology, chemistry, molecular biology, immunology and microbiology. As such, the book is a valuable resource for students, researchers and clinicians interested in the fundamental as well as applied aspects of oxidative stress associated diseases.

Realizing the Promise of Precision Medicine: The Role of Patient Data, Mobile Technology, and Consumer Engagement explains the potential of personalized medicine and the value of those approaches in making that potential a reality. The book helps transform one-size-fits-all healthcare into a system that focuses on individual needs and the unique needs of each family member, discussing topics such as U.S. sponsored precision medicine initiative, genomics, the role of electronic health records and mobile medicine, patient engagement and empowerment, health information exchange and patient data protection. In addition, the book discusses the barriers and limitations of precision medicine and how to overcome them. Readers will find valuable insights into how big data, patient engagement, mobile technology, and genomics help individualize medical care and offer a pathway to help detect many undiscovered causes of diseases.

Up-to-Date Details on Using Ultrasound Imaging to Help Diagnose Various Diseases Due to improvements in image quality and the reduced cost of advanced features, ultrasound imaging is playing a greater role in the diagnosis and image-guided intervention of a wide range of diseases. Ultrasound Imaging and Therapy highlights the latest advances in using ultrasound imaging in image-guided interventions and ultrasound-based therapy. The book presents current and emerging techniques, identifies trends in the use of ultrasound imaging, and addresses technical and computational problems that need to be solved. The book is organized into three sections. The first section covers advances in technology, including transducers (2-D, 3-D, and 4-D), beamformers, 3-D imaging systems, and blood velocity estimation systems. The second section focuses on diagnostic applications, such as elastography, quantitative techniques for therapy monitoring and diagnostic imaging, and ultrasound tomography. The final section explains the use of ultrasound in image-guided interventions for image-guided biopsy and brain imaging.

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. Cutting-edge coverage of stem cell biology and applicationsFeaturing contributions from leading global experts, this authoritative volume addresses all major areas of stem cell biology and their potential therapeutic applications. The first part of the book covers embryonic stem cells and contains details on the emerging field of embryonic stem cell-based drug screening platforms. The second part deals with multipotent adult stem cells from different tissue types, and covers unique concepts such as cancer stem cells and tissue engineering-based approaches for designing microenvironments for tissue regeneration. Eighty pages of inserts with 113 color figures are included in this pioneering work. Coverage includes: Zebrafish, medaka, chicken embryonic, and mouse embryonic stem cells Derivation of human embryonic stem cells (hESCs) from blastocysts Treating diabetes with hESCs hESCs as a model system to study human genetics Application of hESCs in drug discovery Adult stem cells for regenerative medicine and cancer therapies Mesenchymal stem cells for neurodegenerative disease therapies Dental pulp, hematopoietic, and spermatogonial stem cells Epigenetic regulators of stem cell pluripotency Cancer stem cells

This book investigates the transfer of technology from basic research to society. When transferring technology, two main ways may arise: licensing out the further exploitation rights straight from the University departments to the industry or joining the technology a step beyond into market applications for products and services development, through spin-off and startup companies. This book focuses on the second process and the stakeholders involved, with several study cases from real life. Profiles of research entrepreneurs are described, along with categories and general characteristics of entrepreneurial infrastructure. Different phases of launching university ventures are presented, as well as currently perceived technology transfer systems. Important practical considerations for IP protection are included. Case studies of research transfer are shortly given, related to nanotechnology, biomaterials and magnetic sensing applications.The book was written by experts in the field with extensive practical experience in both academic and entrepreneurship real life cases, thus being able to uniquely integrate both approaches to spin-offs and startups.

As health care is moving toward a team effort with patients as partners, this book provides guidance on the optimized use of health information and supporting technologies, and how people think and make decisions that affect their health and wellbeing. It focuses on investigations of how general public understand health information, assess risky behaviors, make healthcare decisions, and how they use health information technologies. e-health technologies have opened up new horizons for promoting increased self-reliance in patients. Although information technologies are now in widespread use, there is often a disparity between the scientific and technological knowledge underlying health care practices and the cultural beliefs, mental models, and cognitive representations of illness and disease. Misconceptions based on inaccurate perceptions and mental models, and flawed prior beliefs could lead to miscommunication as well as to erroneous decisions about individuals' own health or the health of their family members. Cognitive Informatics in Health and Biomedicine: Understanding and Modeling Health Behaviors presents state of the art research in cognitive informatics for assessing the impact of patient behaviour. It is designed to assist all involved at the intersection of the health care institution and the patient and covers contributions from recognized researchers and leaders in the field.

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. Master Artificial Tactile Sensing Design for Biomedical Engineering ApplicationsFilled with high-quality photographs and illustrations, including some in color, this definitive guide details the design and manufacturing of artificial tactile systems and their applications in surgical procedures. Artificial Tactile Sensing in Biomedical Engineering explains the fundamentals of the human sense of touch and the latest techniques for artificially replicating it. The book describes the mechanistic principles of static and dynamic tactile sensors and discusses cutting-edge biomedical applications, including minimally invasive surgery, tumor detection, robotic surgery, and surgical simulations. Artificial Tactile Sensing in Biomedical Engineering covers: Capacitive, magnetic, inductive, conductive elastomeric, optical, and thermal sensors Strain gauge and piezoelectric sensors Tactile sensing in surgery and palpation Tactile image information through palpation Tumor detection via artificial tactile sensing Estimating tumor parameters using the finite element method and an artificial neural network Determination of mechanical properties of biological tissues Tactile sensing in remote and robotic surgery Haptics application in surgical simulation

This book covers biological synthesis approaches for nanomaterials and nanoparticles, including introductory material on their structure, phase compositions and morphology, nanomaterials chemical, physical, and biological properties. The chapters of this book describe in sequence the synthesis of various nanoparticles by microorganisms, bacteria, yeast, algae, and actynomycetes; plant and plant extract-based synthesis; and green synthesis methods. Each chapter provides basic knowledge on the synthesis of nanomaterials, defines fundamental terms, and aims to build a solid foundation of knowledge, followed by explanations, examples, visual photographs, schemes, tables and illustrations. Each chapter also contains control questions, problem drills, as well as case studies that clarify theory and the explanations given in the text. This book is ideal for researchers and advanced graduate students in materials engineering, biotechnology, and nanotechnology fields. As a reference book this work is also appropriate for engineers in R&D and product manufacturing.

This detailed volume focuses on the CRISPR-associated guide RNA and how it can be designed, modified, and validated for a broad repertoire of purposes. Beginning with a section on computational design of target-specific guide RNAs, the book continues by covering chemical modifications to alter guide RNA stability, specificity, and efficiency, as well as to create inducible guide RNAs, append additional functional domains, and express guide RNAs in a conditional manner. It concludes with methods for measuring off-target guide RNA activity. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and essential, CRISPR Guide RNA Design: Methods and Protocols provides a comprehensive pipeline for guide RNA design and aims to be an invaluable resource in applying this powerful technology to basic research and therapeutic applications.

This book sheds new light on ways to alleviate biotic and abiotic stress in plants, using signaling molecules of plant growth promotory rhizobacteria. Further, it elaborates on the different types of stress and strategies used by plants under various stress conditions. The respective sections describe the importance of the microbiome for the overall health of plants and how exploring plant-microbe communication and signaling pathways could offer a promising avenue for future research. The book also discusses how rhizobacteria could be exploited in stress alleviation and sustainable agriculture, and addresses omics strategies for stress response and mitigation. Thanks to clearly annotated references, the book also supports and encourages readers to further explore the topics discussed.

Dentistry is a branch of medicine with its own peculiarities and very diverse areas of action, which means that it can be considered as an interdisciplinary field. BIODENTAL ENGINEERING II contains the full papers presented at the 2nd International Conference on Biodental Engineering (BioDENTAL 2012, Porto, Portugal, 7-8 December 2012). The contributions from 8 countries provide a comprehensive, multi-disciplinary coverage of the state-of-the-art in biodental engineering, and include the following subjects: * Aesthetics * Bioengineering * Biomaterials * Biomechanical disorders * Biomedical devices * Computational bio-imaging and visualization * Computational methods * Dental medicine * Experimental mechanics * Signal processing and analysis * Implantology * Minimally invasive devices and techniques * Orthodontics * Prosthesis and orthosis * Simulation * Software development * Telemedicine * Tissue engineering * Virtual reality BIODENTAL ENGINEERING II intends to cover recent advances in new techniques and technologies, and will be of interest to academics and others interested in biodental engineering.

This book describes the development of quantitative techniques for ultrasound and photoacoustic imaging in the assessment of architectural and vascular parameters. It presents morphological vascular research based on the development of quantitative imaging techniques for the use of clinical B-mode ultrasound images, and preclinical architectural vascular investigations on quantitative imaging techniques for ultrasounds and photoacoustics. The book is divided into two main parts, the first of which focuses on the development and validation of quantitative techniques for the assessment of vascular morphological parameters that can be extracted from B-mode ultrasound longitudinal images of the common carotid artery. In turn, the second part highlights quantitative imaging techniques for assessing the architectural parameters of vasculature that can be extracted from 3D volumes, using both contrast-enhanced ultrasound (CEUS) imaging and photoacoustic imaging without the addition of any contrast agent. Sharing and summarizing the outcomes of this important research, the book will be of interest to a broad range of researchers and practitioners in the fields of medical imaging and biomedical engineering.

Biomaterials: Principles and Applications offers a comprehensive review of all the major biomaterials in this rapidly growing field. In recent years, the role of biomaterials has been influenced considerably by advances in many areas of biotechnology and science, as well as advances in surgical techniques and instruments. Comprising chapters contributed by a panel of international experts, this text provides a familiarity with the uses of materials in medicine and dentistry and the rational basis for these applications. It covers such subjects as biodegradable polymeric materials and their relation to tissue engineering, biologic materials, and biomaterials applications in soft and hard tissues. Nearly one hundred figures and tables further add to the value of this book. The text is concise, topical, and not overly technical - No other book covers the entire field of biomaterials so succinctly in one volume.

This book comprehensively reviews the various automated and semi-automated signal and image processing techniques, as well as deep-learning-based image analysis techniques, used in healthcare diagnostics. It highlights a range of data pre-processing methods used in signal processing for effective data mining in remote healthcare, and discusses pre-processing using filter techniques, noise removal, and contrast-enhanced methods for improving image quality. The book discusses the status quo of artificial intelligence in medical applications, as well as its future. Further, it offers a glimpse of feature extraction methods for reducing dimensionality and extracting discriminatory information hidden in biomedical signals. Given its scope, the book is intended for academics, researchers and practitioners interested in the latest real-world technological innovations.

The book describes the core resources in informatics necessary to support biomedical research programs and how these can best be integrated with hospital systems to receive clinical information that is necessary to conduct translational research. The focus is on the authors' recent practical experiences in establishing an informatics infrastructure in a large research-intensive children's hospital. This book is intended for translational researchers and informaticians in pediatrics, but can also serve as a guide to all institutions facing the challenges of developing and strengthening informatics support for biomedical research. The first section of the book discusses important technical challenges underlying computer-based pediatric research, while subsequent sections discuss informatics applications that support biobanking and a broad range of research programs. Pediatric Biomedical Informatics provides practical insights into the design, implementation, and utilization of informatics infrastructures to optimize care and research to benefit children.

Mechanics of Biological Systems and Materials, Volume 6 of the Proceedings of the 2016 SEM Annual Conference & Exposition on Experimental and Applied Mechanics, the sixth volume of ten from the Conference, brings together contributions to this important area of research and engineering. The collection presents early findings and case studies on a wide range of areas, including: Soft Material Mechanics Bio-Engineering and Biomechanics Cells Mechanics Biomaterials and Mechanics Across Multiple Scales Biomechanics Biotechnologies Traumatic Brain Injury Mechanics

Prostheses, assistive systems, and rehabilitation systems are essential to increasing the quality of life for people with disabilities. Research and development over the last decade has resulted in enormous advances toward that goal-none more so than the development of intelligent systems and technologies.

In the first truly comprehensive book addressing intelligent technologies for the disabled, top experts from around the world provide an overview of this dynamic, rapidly evolving field. They present state-of-the-art information on the latest, innovative technologies and their applications in various systems designed to better the lives of the disabled.

From the underlying principles to the design, practical applications, and assessment of results, Intelligent Systems and Technologies in Rehabilitation Engineering offers broad, pragmatic coverage of the field. It incorporates the most recent advances in sensory and limb prostheses, myoelectric control systems, circulatory systems, assistive technologies, and applications of virtual reality.

Rapid progress demands a concerted effort to keep up with the latest developments so they can begin to serve their purpose and improve the lives of the disabled. By incorporating details of the latest and most important advances into one volume, Intelligent Systems and Technologies in Rehabilitation Engineering makes that undertaking essentially effortless.

Biomaterials have had a major impact on the practice of contemporary medicine and patient care. Growing into a major interdisciplinary effort involving chemists, biologists, engineers, and physicians, biomaterials development has enabled the creation of high-quality devices, implants, and drug carriers with greater biocompatibility and biofunctionality. The fast-paced research and increasing interest in finding new and improved biocompatible or biodegradable polymers has provided a wealth of new information, transforming this edition of Polymeric Biomaterials into a two-volume set. This volume, Polymeric Biomaterials: Medicinal and Pharmaceutical Applications, contains 28 authoritative chapters written by experts from around the world. Contributors cover the following topics: Processing polymeric biomaterials into specific forms that ensure biocompatibility and biodegradability for use in various applications in the medical and pharmaceutical arenas Use of biomaterials to address medical issues such as pulmonary disease, cancer, heart disease, tissue damage, and bone disease Applications including a variety of drug delivery systems, medical devices, anticancer therapies, biological uses for hydrogels, nanotechnology, bioartificial organs, and tissue engineering Completely revised and expanded, this state-of-the-art reference presents recent developments in polymeric biomaterials and the most up-to-date applications of biomaterials in medicine.

This unique text presents a comprehensive review of methods for modeling signal and noise in magnetic resonance imaging (MRI), providing a systematic study, classifying and comparing the numerous and varied estimation and filtering techniques. Features: provides a complete framework for the modeling and analysis of noise in MRI, considering different modalities and acquisition techniques; describes noise and signal estimation for MRI from a statistical signal processing perspective; surveys the different methods to remove noise in MRI acquisitions from a practical point of view; reviews different techniques for estimating noise from MRI data in single- and multiple-coil systems for fully sampled acquisitions; examines the issue of noise estimation when accelerated acquisitions are considered, and parallel imaging methods are used to reconstruct the signal; includes appendices covering probability density functions, combinations of random variables used to derive estimators, and useful MRI datasets.

Biomaterials have had a major impact on the practice of contemporary medicine and patient care. Growing into a major interdisciplinary effort involving chemists, biologists, engineers, and physicians, biomaterials development has enabled the creation of high-quality devices, implants, and drug carriers with greater biocompatibility and biofunctionality. The fast-paced research and increasing interest in finding new and improved biocompatible or biodegradable polymers has provided a wealth of new information, transforming this edition of Polymeric Biomaterials into a two-volume set. This volume, Polymeric Biomaterials: Structure and Function, contains 25 authoritative chapters written by experts from around the world. Contributors cover the following topics: The structure and properties of synthetic polymers including polyesters, polyphosphazenes, and elastomers The structure and properties of natural polymers such as mucoadhesives, chitin, lignin, and carbohydrate derivatives Blends and composites-for example, metal-polymer composites and biodegradable polymeric/ceramic composites Bioresorbable hybrid membranes, drug delivery systems, cell bioassay systems, electrospinning for regenerative medicine, and more Completely revised and expanded, this state-of-the-art reference presents recent developments in polymeric biomaterials: from their chemical, physical, and structural properties to polymer synthesis and processing techniques and current applications in the medical and pharmaceutical fields.