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MATLAB Programming for Biomedical Engineers and Scientists provides an easy-to-learn introduction to the fundamentals of computer programming in MATLAB. This book explains the principles of good programming practice, while demonstrating how to write efficient and robust code that analyzes and visualizes biomedical data. Aimed at the biomedical engineer, biomedical scientist, and medical researcher with little or no computer programming experience, it is an excellent resource for learning the principles and practice of computer programming using MATLAB. This book enables the reader to: Analyze problems and apply structured design methods to produce elegant, efficient and well-structured program designs Implement a structured program design in MATLAB, making good use of incremental development approaches Write code that makes good use of MATLAB programming features, including control structures, functions and advanced data types Write MATLAB code to read in medical data from files and write data to files Write MATLAB code that is efficient and robust to errors in input data Write MATLAB code to analyze and visualize medical data, including imaging data For a firsthand interview with the authors, please visit http://scitechconnect.elsevier.com/matlab-programming-biomedical-engineers-scientists/ To access student materials, please visit https://www.elsevier.com/books-and-journals/book-companion/9780128122037 To register and access instructor materials, please visit http://textbooks.elsevier.com/web/Manuals.aspx?isbn=9780128122037
"Microalgae Biotechnology for Food, Health and High Value Products" presents the latest technological innovations in microalgae production, market status of algal biomass-based products, and future prospects for microalgal applications. It provides stimulating overviews from different perspectives of application that demonstrate how rapidly the commercial production of microalgae-based food, health and high value products is advancing. It also addresses a range of open questions and challenges in this field. The book highlights the latest advances of interest to those already working in the field, while providing a comprehensive overview for those readers just beginning to learn about the promise of microalgae as a sustainable source of both specialty and commercial products. It offers a valuable asset for commercial algae producers, algae product developers, scientific researchers and students who are dedicated to the advancement of microalgae biotechnology for applications in health, diet, nutrition, cosmetics, biomaterials etc.
Comprehensive Biomaterials II, Second Edition brings together the myriad facets of biomaterials into one expertly-written series of edited volumes. Articles address the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, research and development, regulatory management, commercial aspects, and applications, including medical applications. Detailed coverage is given to both new and emerging areas and the latest research in more traditional areas of the field. Particular attention is given to those areas in which major recent developments have taken place. This new edition, with 75% new or updated articles, will provide biomedical scientists in industry, government, academia, and research organizations with an accurate perspective on the field in a manner that is both accessible and thorough.
A complete mathematical guide to creating models for the distribution of properties of cell populations .
. "Population Balances in Biomedical Engineering: Segregation through the Distribution of Cell States" offers a framework for developing and solving simple models that are essential to determining the distribution of properties of cell populations and analyzing their underlying dynamic behavior..
. This rigorous resource takes a quantitative approach to overcoming obstacles that researchers face in building models that accurately approximate properties and classification of various cell populations. Coverage includes: . Population balancing techniques for filamentous organisms. Control points of steady-state and transient solutions. Methods for analysis of the underlying behavior of cellular systems.
. A Powerful Statistical Approach to Population Balance
Brain science is at the dawn of a new era-and the technologies emerging as a result could forever alter what it means to be human. Welcome to what tech pioneer and inventor Tan Le calls "the NeuroGeneration." It will blow your mind. The human brain is perhaps the most powerful and mysterious arrangement of matter in the known universe. New discoveries that unravel this mystery and let us tap into this power offer almost limitless potential-the ability to reshape ourselves and our thought processes, to improve our health and extend our lives, and to enhance and augment the ways we interact with the world around us. It may sound like the stuff of science fiction, but it is quickly becoming reality. In The NeuroGeneration, award-winning inventor Tan Le explores exciting advancements in brain science and neurotechnology that are revolutionizing the way we think, work, and heal. Join Le as she criss-crosses the globe, introducing the brilliant neurotech innovators and neuroscientists at the frontiers of brain enhancement. Along the way, she shares incredible stories from individuals whose lives are already being transformed by their inventions-an endurance racer paralyzed in a fall, who now walks thanks to neural stimulation and an exoskeleton; a man who drives a race car with his mind; even a color-blind "cyborg" whose brain implant allows him to "hear" colors. The NeuroGeneration reveals the dizzying array of emerging technologies-including cranial stimulation that makes you learn faster, an artificial hippocampus that restores lost memories, and neural implants that aim to help us keep up with or even outpace artificial intelligence-that promise to alter the brain in unprecedented ways, unlocking human potential we never dreamed possible. Le also explores how these futuristic innovations will impact our world, disrupt the way we do business, upend healthcare as we know it, and remake our lives in wondrous and unexpected ways. As fascinating as it is timely, The NeuroGeneration offers a thrilling glimpse of the future of our species, and how changing our brains can change human life as we know it.
This volume explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease, and psychiatry. Additional chapters focus on methodology, technologies and instrumentation, as well as on analysis of protein-protein interactions, protein quantitation, and protein post-translational modifications. Various omics fields such as proteomics, metabolomics, glycomics, lipidomics, and adductomics are also covered. Applications of mass spectrometry in biotechnological and pharmaceutical industry are also discussed. This volume provides readers with a comprehensive and informative manual that will allow them to appreciate mass spectrometry and proteomic research, but also to initiate and improve their own work. This book acts as a technical guide as well as a conceptual guide to the newest information in this exciting field.
Learn about the theory, techniques and applications of wavefront shaping in biomedical imaging using this unique text. With authoritative contributions from researchers who are defining the field, cutting-edge theory is combined with real-world practical examples, experimental data and the latest research trends to provide the first book-level treatment of the subject. It is suitable for both background reading and use in a course, with coverage of essential topics such as adaptive optical microscopy, deep tissue microscopy, time reversal and optical phase conjugation, and tomography. The latest images from the forefront of biomedical imaging are included, and full-colour versions are available in the eBook version. Researchers, practitioners and graduate students in optics, biophotonics, biomedical engineering, and biology who use biomedical imaging tools and are looking to advance their knowledge of the subject will find this an indispensable resource.
This book explains how current medicines against cancer work and how we find new ones. It provides an easy-to-understand overview of current options to treat patients with cancer, which includes Surgery, Radiation therapy, Chemotherapy, Targeted therapy and Immunotherapy. The efficiency of all these treatments is limited by the capacity of cancer cells to escape therapy. This book explains the mechanisms of anti-cancer drug resistance and strategies to overcome it. The discovery and development process of a new drug is detailed beginning with the identification and validation of a therapeutic target, the identification of an inhibitor of the target and its subsequent preclinical and clinical development until its approval by regulatory authorities. Particular emphasis has been given to specific aspects of the development process including lead generation and optimization, pharmacokinetics, ADME analysis, pharmacodynamics, toxicity and efficacy assessment, investigational new drug (IND) and new drug application (NDA) and the design of clinical trial and their phases. The book covers many aspects of modern personalized oncology and discusses economic aspects of our current system of developing new medicines and its impact on our societies and on future drug research. The author of this book, Dr. Link counts with more than 20 years of experience in biomedical research reflected in numerous publications, patents and key note and plenary presentations at international conferences. Interested readers, students and teachers should read this book as it provides a unique way to learn/teach about basic concepts in oncology and anti-cancer drug research.
This volume describes breeding methods for the development of biparental and multiparental mapping populations. Chapters detail lab protocols for high-throughput isolation of nucleic acids and metabolites, high performing genotyping approaches, mapping strategies for QTLs, mutation identifications, computational, bioinformatic pipelines, tissue culture-based and transformation methods for androgenesis, ploidy modification, and RNA interference. Additional chapters highlight recent developed genome editing protocols including CRISPR and TALEN methods and methodologies for in-field/in-soil plant phenotyping. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Crop Breeding: Genetic Improvement Methods aims to ensure successful results in the further study of this vital field.
This book reviews recent advances in the emerging field of computational network biology with special emphasis on comparative network analysis and network module detection. The chapters in this volume are contributed by leading international researchers in computational network biology and offer in-depth insight on the latest techniques in network alignment, network clustering, and network module detection. Chapters discuss the advantages of the respective techniques and present the current challenges and open problems in the field. Recent Advances in Biological Network Analysis: Comparative Network Analysis and Network Module Detection will serve as a great resource for graduate students, academics, and researchers who are currently working in areas relevant to computational network biology or wish to learn more about the field. Data scientists whose work involves the analysis of graphs, networks, and other types of data with topological structure or relations can also benefit from the book's insights.
This book covers two most important applications of smart sensors, namely bio-health sensing and environmental monitoring. The approach taken is holistic and covers the complete scope of the subject matter from the principles of the sensing mechanism, through device physics, circuit and system implementation techniques, and energy issues to wireless connectivity solutions. It is written at a level suitable mainly for post-graduate level researchers interested in practical applications. The chapters are independent but complementary to each other, and the book works within the wider perspective of essential smart sensors for the Internet of Things (IoT). This is the second of three books based on the Integrated Smart Sensors research project, which describe the development of innovative devices, circuits, and system-level enabling technologies. The aim of the project was to develop common platforms on which various devices and sensors can be loaded, and to create systems offering significant improvements in information processing speed, energy usage, and size. This book contains substantial reference lists and over 150 figures, introducing the reader to the subject in a tutorial style whilst also addressing state-of-the-art research results, allowing it to be used as a guide for starting researchers.
The International Congress on Neurotechnology, Electronics, and Informatics (NEUROTECHNIX) took place in Algarve, Portugal in September of 2013. The congress provided a meeting point of academics and clinical and engineering professionals, promoting translational discussions on how research and technology can meet the needs of clinical practitioners and patients. NEUROTECHNIX emphasized research and application of neurotechnologies to various neurological disorders, including neuromuscular diseases, Parkinson's disease, developmental disorders, dementia, epilepsy, sleep disorders, Multiple Sclerosis, neuroinfections, brain tumors, stroke, traumatic brain injuries, Cerebral Palsy, spinal cord injury and vision and hearing disorders. Authors were invited to submit innovative research work that highlighted new advancements of neurotechnology. Papers describing case studies, advanced prototypes, systems, tools and techniques and general survey papers indicating future directions were encouraged. This book contains a limited selection of extended and revised versions of the best papers presented at the congress, by regular and keynote speakers.
This unique introductory text explains cell functions using the engineering principles of robust devices. Adopting a process-based approach to understanding cell and tissue biology, it describes the molecular and mechanical features that enable the cell to be robust in operating its various components, and explores the ways in which molecular modules respond to environmental signals to execute complex functions. The design and operation of a variety of complex functions are covered, including engineering lipid bilayers to provide fluid boundaries and mechanical controls, adjusting cell shape and forces with dynamic filament networks, and DNA packaging for information retrieval and propagation. Numerous problems, case studies and application examples help readers connect theory with practice, and solutions for instructors and videos of lectures accompany the book online. Assuming only basic mathematical knowledge, this is an invaluable resource for graduate and senior undergraduate students taking single-semester courses in cell mechanics, biophysics and cell biology.
Non-Invasive Instrumentation and Measurement in Medical Diagnosis, Second Edition discusses NIMD as a rapidly growing, interdisciplinary field. The contents within this second edition text is derived from Professor Robert B. Northrop's experience teaching for over 35 years in the Biomedical Engineering Department at the University of Connecticut. The text focusses on the instruments and procedures which are used for non-invasive medical diagnosis and therapy, highlighting why NIMD is the preferred procedure, whenever possible, to avoid the risks and expenses associated with surgically opening the body surface. This second edition also covers a wide spectrum of NIMD topics including: x-ray bone densitometry by the DEXA method; tissue fluorescence spectroscopy; optical interferometric measurement of nanometer tissue displacements; laser Doppler velocimetry; pulse oximetry; and applications of Raman spectroscopy in detecting cancer, to name a few. This book is intended for use in an introductory classroom course on Non-Invasive Medical Instrumentation and Measurements taken by juniors, seniors, and graduate students in Biomedical Engineering. It will also serve as a reference book for medical students and other health professionals intrigued by the topic. Practicing physicians, nurses, physicists, and biophysicists interested in learning state of the art techniques in this critical field will also find this text valuable. Non-Invasive Instrumentation and Measurement in Medical Diagnosis, Second Edition concludes with an expansive index, bibliography, as well as a comprehensive glossary for future reference and reading.
This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology - New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.
Highlighting dynamic developments in polymer synthesis, this book focuses on the chemical techniques to synthesize and characterize biomedically relevant polymers and macromolecules. Aids researchers developing polymers and materials for biomedical applications Describes biopolymers from a synthetic perspective, which other similar books do not do Covers areas that include: cationically-charged macromolecules, pseudo-peptides, polydrugs and prodrugs, controlled radical polymerization, self-assembly, polycondensates, and polymers for surface modification
This edited volume explores the use of technology to enable us to visualise the life sciences in a more meaningful and engaging way. It will enable those interested in visualisation techniques to gain a better understanding of the applications that can be used in imaging and analysis, education, engagement and training. The reader will be able to explore the utilisation of technologies from a number of fields to enable an engaging and meaningful visual representation of the life sciences. This use of technology-enhanced learning will be of benefit for the learner, trainer, in patient care and the wider field of education and engagement. By examining a range of techniques in image capture (photogrammetery, stereophotogrammetry, microphotogrammetry and autostereoscopy), this book will showcase the wide range of tools we can use. Researchers in this field will be able to find something suitable to apply to their work to enhance user engagement through improved visual means using the technologies we have available to us today. It will highlight the uses of these technologies to examine many aspects of the human body, and enable improved ways to enhance visual and tactile learning, including 3D printing. By demonstrating co-design processes, working directly with the end-stage users (including patients), it will also highlight successes in adopting tools like hand motion tracking rehabilitation for patients with conditions like multiple sclerosis. The book will also discuss the applications of immersive environments including virtual, augmented and mixed reality. The ultimate aim is to show how, by using these tools, we can enhance communication, mobile applications, health literacy and illustration of both normal and pathological processes in the body. By applying a wide range of tools and technologies, this volume will highlight the wide range of applications in education, training and learning both for students and faculty, but also for patient care and education. Therefore, the work presented here can be accessed by a wide range of users from faculty and students involved in the design and development of these processes, by examining the pedagogy around these technologies. Importantly, it presents material, which will be of benefit for the patient, engaging them to become more involved with techniques like physiotherapy.
This edited book explores the use of technology to enable us to visualise the life sciences in a more meaningful and engaging way. It will enable those interested in visualisation techniques to gain a better understanding of the applications that can be used in visualisation, imaging and analysis, education, engagement and training. The reader will be able to explore the utilisation of technologies from a number of fields to enable an engaging and meaningful visual representation of the biomedical sciences, with a focus in this volume related to anatomy, and clinically applied scenarios. The first six chapters have an anatomical focus examining digital technologies and applications to enhance education. The first examines the history and development of ultrasound, applications in an educational setting, and as a point-of-care ultrasound at the bedside. The second chapter presents a transferable workflow methodology in creating an interactive educational and training package to enhance understanding of the circadian rhythm. The third chapter reviews tools and technologies, which can be used to enhance off-campus learning, and the current range of visualisation technologies like virtual, augmented and mixed reality systems. Chapter four discusses how scanning methodologies like CT imagery, can make stereoscopic models. The fifth chapter describes a novel way to reconstruct 3D anatomy from imaging datasets and how to build statistical 3D shape models, described in a clinical context and applied to diagnostic disease scoring. The sixth chapter looks at interactive visualisations of atlases in the creation of a virtual resource, for providing next generation interfaces. The seventh and eight chapters discuss neurofeedback for mental health education and interactive visual data analysis (applied to irritable bowel disease) respectively. The final two chapters examine current immersive technologies -virtual and augmented reality, with the last chapter detailing virtual reality in patients with dementia. This book is accessible to a wide range of users from faculty and students, developers and computing experts, the wider public audience. It is hoped this will aid understanding of the variety of technologies which can be used to enhance understanding of clinical conditions using modern day methodologies.
With mathematical and computational models furthering our understanding of lung mechanics, function and disease, this book provides an all-inclusive introduction to the topic from a quantitative standpoint. Focusing on inverse modeling, the reader is guided through the theory in a logical progression, from the simplest models up to state-of-the-art models that are both dynamic and nonlinear. Key tools used in biomedical engineering research, such as regression theory, linear and nonlinear systems theory, and the Fourier transform, are explained. Derivations of important physical principles, such as the Poiseuille equation and the wave speed equation, from first principles are also provided. Example applications to experimental data throughout illustrate physiological relevance, whilst problem sets at the end of each chapter provide practice and test reader comprehension. This book is ideal for biomedical engineering and biophysics graduate students and researchers wishing to understand this emerging field.
This book presents the latest research on the uses of polyhydroxyalkanoates (PHA), introducing readers to these natural, biodegradable polyesters produced by microorganisms, their functions and applications. The individual chapters discuss the various potentials of these bioplastics, which offer an attractive alternative to non-biodegradable plastics. The book also describes the diverse medical and biomedical applications of PHAs, including their use as drug carriers, memory enhancers, and biocontrol agents, and examines their role in creating a more sustainable economy - which is the need of the hour.
Taking advantage of the accessibility of the skin "in vivo," non-invasive methods were developed about 40 years ago, which have now developed as accurate sources to measure skin properties and structures at the microscopic and macroscopic levels. However, even at the dawn of the twenty-first century, the mechanisms involved in these properties are still only partly understood. As in many domains, including biomedical engineering, numerical modeling has appeared as a complementary key actor for improving our knowledge on skin physiology.
This book gathers, for the first time, chapters describing scientific computing and numerical modeling for a deeper understanding of mechanisms involved in skin physiology. The book is structured around some skin properties and functions, including optical and biomechanical properties, skin barrier function, and homeostasis, covered through several chapters describing either biological or physical models at different scales.
The book introduces the latest advances in dental materials and biomaterials science. It contains a comprehensive introduction and covers ceramic, metallic, and polymeric oral biomaterials. The contributing authors are from all over the world and are distinguished in their disciplines. A solid primer for dental students, the book is also highly recommended for students of engineering and basic science who want to gain an insight in contemporary biomaterials science. For medical practitioners, the book offers an invaluable opportunity to learn about the latest steps in dental biomaterials.
This book is a compendium of the ICCMIA 2018 proceedings, which provides an ideal reference for all medical imaging researchers and professionals to explore innovative methods and analyses on imaging technologies for better prospective patient care. This work serves as an exclusive source for new computer assisted clinical and medical developments in imaging diagnosis, intervention and analysis. It includes articles on computer assisted medical scanning techniques, computer-aided diagnosis, robotic surgery and imaging, imaging genomics, clinically-oriented imaging physics and informatics, augmented-reality medical visualization, imaging modalities, computerized radiology, oncology, and surgery. Moreover, information on non-medical imaging that has medical applications such as multi-photon microscopy and confocal, photoacoustic imaging, optical microendoscope, infra-red radiation, and other imaging modalities is also represented.
Statistical Computing in Nuclear Imaging introduces aspects of Bayesian computing in nuclear imaging. The book provides an introduction to Bayesian statistics and concepts and is highly focused on the computational aspects of Bayesian data analysis of photon-limited data acquired in tomographic measurements. Basic statistical concepts, elements of decision theory, and counting statistics, including models of photon-limited data and Poisson approximations, are discussed in the first chapters. Monte Carlo methods and Markov chains in posterior analysis are discussed next along with an introduction to nuclear imaging and applications such as PET and SPECT. The final chapter includes illustrative examples of statistical computing, based on Poisson-multinomial statistics. Examples include calculation of Bayes factors and risks as well as Bayesian decision making and hypothesis testing. Appendices cover probability distributions, elements of set theory, multinomial distribution of single-voxel imaging, and derivations of sampling distribution ratios. C++ code used in the final chapter is also provided. The text can be used as a textbook that provides an introduction to Bayesian statistics and advanced computing in medical imaging for physicists, mathematicians, engineers, and computer scientists. It is also a valuable resource for a wide spectrum of practitioners of nuclear imaging data analysis, including seasoned scientists and researchers who have not been exposed to Bayesian paradigms.
With its content taken from only the very latest results, this is an extensive summary of the various polymeric materials used for biomedical applications. Following an introduction listing various functional polymers, including conductive, biocompatible and conjugated polymers, the book goes on to discuss different synthetic polymers that can be used, for example, as hydrogels, biochemical sensors, functional surfaces, and natural degradable materials. Throughout, the focus is on applications, with worked examples for training purposes as well as case studies included. The whole is rounded off with a look at future trends.
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