Many of our daily-life problems can be written in the form of an optimization problem. Therefore, solution methods are needed to solve such problems. Due to the complexity of the problems, it is not always easy to find the exact solution. However, approximate solutions can be found. The theory of the best approximation is applicable in a variety of problems arising in nonlinear functional analysis and optimization. This book highlights interesting aspects of nonlinear analysis and optimization together with many applications in the areas of physical and social sciences including engineering. It is immensely helpful for young graduates and researchers who are pursuing research in this field, as it provides abundant research resources for researchers and post-doctoral fellows. This will be a valuable addition to the library of anyone who works in the field of applied mathematics, economics and engineering.

Very little has been published on optimization of pharmaceutical portfolios. Moreover, most of published literature is coming from the commercial side, where probability of technical success (PoS) is treated as fixed, and not as a consequence of development strategy or design. In this book there is a strong focus on impact of study design on PoS and ultimately on the value of portfolio. Design options that are discussed in different chapters are dose-selection strategies, adaptive design and enrichment. Some development strategies that are discussed are indication sequencing, optimal number of programs and optimal decision criteria. This book includes chapters written by authors with very broad backgrounds including financial, clinical, statistical, decision sciences, commercial and regulatory. Many authors have long held executive positions and have been involved with decision making at a product or at a portfolio level. As such, it is expected that this book will attract a very broad audience, including decision makers in pharmaceutical R&D, commercial and financial departments. The intended audience also includes portfolio planners and managers, statisticians, decision scientists and clinicians. Early chapters describe approaches to portfolio optimization from big Pharma and Venture Capital standpoints. They have stronger focus on finances and processes. Later chapters present selected statistical and decision analysis methods for optimizing drug development programs and portfolios. Some methodological chapters are technical; however, with a few exceptions they require a relatively basic knowledge of statistics by a reader.

This book is the first easy-to-read text on nonsmooth optimization (NSO, not necessarily differentiable optimization). Solving these kinds of problems plays a critical role in many industrial applications and real-world modeling systems, for example in the context of image denoising, optimal control, neural network training, data mining, economics and computational chemistry and physics. The book covers both the theory and the numerical methods used in NSO and provide an overview of different problems arising in the field. It is organized into three parts: 1. convex and nonconvex analysis and the theory of NSO; 2. test problems and practical applications; 3. a guide to NSO software. The book is ideal for anyone teaching or attending NSO courses. As an accessible introduction to the field, it is also well suited as an independent learning guide for practitioners already familiar with the basics of optimization.

This book presents the latest findings on stochastic dynamic programming models and on solving optimal control problems in networks. It includes the authors' new findings on determining the optimal solution of discrete optimal control problems in networks and on solving game variants of Markov decision problems in the context of computational networks. First, the book studies the finite state space of Markov processes and reviews the existing methods and algorithms for determining the main characteristics in Markov chains, before proposing new approaches based on dynamic programming and combinatorial methods. Chapter two is dedicated to infinite horizon stochastic discrete optimal control models and Markov decision problems with average and expected total discounted optimization criteria, while Chapter three develops a special game-theoretical approach to Markov decision processes and stochastic discrete optimal control problems. In closing, the book's final chapter is devoted to finite horizon stochastic control problems and Markov decision processes. The algorithms developed represent a valuable contribution to the important field of computational network theory.

This book on PDE Constrained Optimization contains contributions on the mathematical analysis and numerical solution of constrained optimal control and optimization problems where a partial differential equation (PDE) or a system of PDEs appears as an essential part of the constraints. The appropriate treatment of such problems requires a fundamental understanding of the subtle interplay between optimization in function spaces and numerical discretization techniques and relies on advanced methodologies from the theory of PDEs and numerical analysis as well as scientific computing. The contributions reflect the work of the European Science Foundation Networking Programme ’Optimization with PDEs’ (OPTPDE).

Statistical Decision Problems presents a quick and concise introduction into the theory of risk, deviation and error measures that play a key role in statistical decision problems. It introduces state-of-the-art practical decision making through twenty-one case studies from real-life applications. The case studies cover a broad area of topics and the authors include links with source code and data, a very helpful tool for the reader. In its core, the text demonstrates how to use different factors to formulate statistical decision problems arising in various risk management applications, such as optimal hedging, portfolio optimization, cash flow matching, classification, and more. The presentation is organized into three parts: selected concepts of statistical decision theory, statistical decision problems, and case studies with portfolio safeguard. The text is primarily aimed at practitioners in the areas of risk management, decision making, and statistics. However, the inclusion of a fair bit of mathematical rigor renders this monograph an excellent introduction to the theory of general error, deviation, and risk measures for graduate students. It can be used as supplementary reading for graduate courses including statistical analysis, data mining, stochastic programming, financial engineering, to name a few. The high level of detail may serve useful to applied mathematicians, engineers, and statisticians interested in modeling and managing risk in various applications.

The International Conference on Health Care Systems Engineering (HCSE) provided a timely opportunity to discuss statistical analysis and operations management issues in health care delivery systems. The conference took place in Milan between May 22nd and 24th, 2013. Scientists and practitioners discussed new ideas, methods and technologies for improving the operation of health care organizations. The event and this resulting volume emphasize research in the field of health care systems engineering developed in close collaboration with clinicians. Topics applicable to researchers and practitioners include: hospital drug logistics, operating theatres, modelling and simulation in patient care and healthcare organizations, home care services.

This textbook is devoted to a compressed and self-contained exposition of two important parts of contemporary mathematics: convex and set-valued analysis. In the first part, properties of convex sets, the theory of separation, convex functions and their differentiability, properties of convex cones in finite- and infinite-dimensional spaces are discussed. The second part covers some important parts of set-valued analysis. There the properties of the Hausdorff metric and various continuity concepts of set-valued maps are considered. The great attention is paid also to measurable set-valued functions, continuous, Lipschitz and some special types of selections, fixed point and coincidence theorems, covering set-valued maps, topological degree theory and differential inclusions. Contents: Preface Part I: Convex analysis Convex sets and their properties The convex hull of a set. The interior of convex sets The affine hull of sets. The relative interior of convex sets Separation theorems for convex sets Convex functions Closedness, boundedness, continuity, and Lipschitz property of convex functions Conjugate functions Support functions Differentiability of convex functions and the subdifferential Convex cones A little more about convex cones in infinite-dimensional spaces A problem of linear programming More about convex sets and convex hulls Part II: Set-valued analysis Introduction to the theory of topological and metric spaces The Hausdorff metric and the distance between sets Some fine properties of the Hausdorff metric Set-valued maps. Upper semicontinuous and lower semicontinuous set-valued maps A base of topology of the spaceHc(X) Measurable set-valued maps. Measurable selections and measurable choice theorems The superposition set-valued operator The Michael theorem and continuous selections. Lipschitz selections. Single-valued approximations Special selections of set-valued maps Differential inclusions Fixed points and coincidences of maps in metric spaces Stability of coincidence points and properties of covering maps Topological degree and fixed points of set-valued maps in Banach spaces Existence results for differential inclusions via the fixed point method Notation Bibliography Index

This book shows how the use of S-variables (SVs) in enhancing the range of problems that can be addressed with the already-versatile linear matrix inequality (LMI) approach to control can, in many cases, be put on a more unified, methodical footing. Beginning with the fundamentals of the SV approach, the text shows how the basic idea can be used for each problem (and when it should not be employed at all). The specific adaptations of the method necessitated by each problem are also detailed. The problems dealt with in the book have the common traits that: analytic closed-form solutions are not available; and LMIs can be applied to produce numerical solutions with a certain amount of conservatism. Typical examples are robustness analysis of linear systems affected by parametric uncertainties and the synthesis of a linear controller satisfying multiple, often conflicting, design specifications. For problems in which LMI methods produce conservative results, the SV approach is shown to achieve greater accuracy. The authors emphasize the simplicity and easy comprehensibility of the SV approach and show how it can be implemented in programs without difficulty so that its power becomes readily apparent. The S-variable Approach to LMI-based Robust Control is a useful reference for academic control researchers, applied mathematicians and graduate students interested in LMI methods and convex optimization and will also be of considerable assistance to practising control engineers faced with problems of conservatism in their systems and controllers.

This book examines optimization problems that in practice involve random model parameters. It details the computation of robust optimal solutions, i.e., optimal solutions that are insensitive with respect to random parameter variations, where appropriate deterministic substitute problems are needed. Based on the probability distribution of the random data and using decision theoretical concepts, optimization problems under stochastic uncertainty are converted into appropriate deterministic substitute problems. Due to the probabilities and expectations involved, the book also shows how to apply approximative solution techniques. Several deterministic and stochastic approximation methods are provided: Taylor expansion methods, regression and response surface methods (RSM), probability inequalities, multiple linearization of survival/failure domains, discretization methods, convex approximation/deterministic descent directions/efficient points, stochastic approximation and gradient procedures and differentiation formulas for probabilities and expectations. In the third edition, this book further develops stochastic optimization methods. In particular, it now shows how to apply stochastic optimization methods to the approximate solution of important concrete problems arising in engineering, economics and operations research.

The authors present a new formal framework for finding the long-run competitive market equilibrium through short-run equilibria by exploiting the operating policies and plant valuations. This "short-run approach" develops ideas of Boiteux and Koopmans. Applied to the peak-load pricing of electricity generated by thermal, hydro and pumped-storage plants, it gives a sound and practical method of valuing the fixed assets-in this case, the river flows and the geological sites suitable for reservoirs. Its main mathematical basis is the producer's short-run profit maximization programme and its dual; their solutions have relatively simple forms that can greatly ease the fixed-point problem of solving for the general equilibrium. Since the optimal values (profit and cost functions) are usually nondifferentiable-this is so when there are joint costs of production such as capacity constraints-nonsmooth calculus is employed to resolve long-standing discrepancies between textbook theory and industrial reality by giving subdifferential extensions of basic results of microeconomics, including the Wong-Viner Envelope Theorem.

Optimization has long been a source of both inspiration and applications for geometers, and conversely, discrete and convex geometry have provided the foundations for many optimization techniques, leading to a rich interplay between these subjects. The purpose of the Workshop on Discrete Geometry, the Conference on Discrete Geometry and Optimization, and the Workshop on Optimization, held in September 2011 at the Fields Institute, Toronto, was to further stimulate the interaction between geometers and optimizers. This volume reflects the interplay between these areas. The inspiring Fejes Toth Lecture Series, delivered by Thomas Hales of the University of Pittsburgh, exemplified this approach. While these fields have recently witnessed a lot of activity and successes, many questions remain open. For example, Fields medalist Stephen Smale stated that the question of the existence of a strongly polynomial time algorithm for linear optimization is one of the most important unsolved problems at the beginning of the 21st century. The broad range of topics covered in this volume demonstrates the many recent and fruitful connections between different approaches, and features novel results and state-of-the-art surveys as well as open problems.

With the proliferation of Software-as-a-Service (SaaS) offerings, it is becoming increasingly important for individual SaaS providers to operate their services at a low cost. This book investigates SaaS from the perspective of the provider and shows how operational costs can be reduced by using "multi tenancy," a technique for consolidating a large number of customers onto a small number of servers. Specifically, the book addresses multi tenancy on the database level, focusing on in-memory column databases, which are the backbone of many important new enterprise applications. For efficiently implementing multi tenancy in a farm of databases, two fundamental challenges must be addressed, (i) workload modeling and (ii) data placement. The first involves estimating the (shared) resource consumption for multi tenancy on a single in-memory database server. The second consists in assigning tenants to servers in a way that minimizes the number of required servers (and thus costs) based on the assumed workload model. This step also entails replicating tenants for performance and high availability. This book presents novel solutions to both problems.

This book explores the extremely modular systems that meet two criteria: they allow the creation of structurally sound free-form structures, and they are comprised of as few types of modules as possible. Divided into two parts, it presents Pipe-Z (PZ) and Truss-Z (TZ) systems. PZ is more fundamental and forms spatial mathematical knots by assembling one type of unit (PZM). The shape of PZ is controlled by relative twists of a sequence of congruent PZMs. TZ is a skeletal system for creating free-form pedestrian ramps and ramp networks among any number of terminals in space. TZ structures are composed of four variations of a single basic unit subjected to affine transformations (mirror reflection, rotation and combination of both).

This book presents and applies a novel efficient meta-heuristic optimization algorithm called Colliding Bodies Optimization (CBO) for various optimization problems. The first part of the book introduces the concepts and methods involved, while the second is devoted to the applications. Though optimal design of structures is the main topic, two chapters on optimal analysis and applications in constructional management are also included. This algorithm is based on one-dimensional collisions between bodies, with each agent solution being considered as an object or body with mass. After a collision of two moving bodies with specified masses and velocities, these bodies again separate, with new velocities. This collision causes the agents to move toward better positions in the search space. The main algorithm (CBO) is internally parameter independent, setting it apart from previously developed meta-heuristics. This algorithm is enhanced (ECBO) for more efficient applications in the optimal design of structures. The algorithms are implemented in standard computer programming languages (MATLAB and C++) and two main codes are provided for ease of use.

The focus of the present volume is stochastic optimization of dynamical systems in discrete time where - by concentrating on the role of information regarding optimization problems - it discusses the related discretization issues. There is a growing need to tackle uncertainty in applications of optimization. For example the massive introduction of renewable energies in power systems challenges traditional ways to manage them. This book lays out basic and advanced tools to handle and numerically solve such problems and thereby is building a bridge between Stochastic Programming and Stochastic Control. It is intended for graduates readers and scholars in optimization or stochastic control, as well as engineers with a background in applied mathematics.

Although they are believed to be unsolvable in general, tractability results suggest that some practical NP-hard problems can be efficiently solved. Combinatorial search algorithms are designed to efficiently explore the usually large solution space of these instances by reducing the search space to feasible regions and using heuristics to efficiently explore these regions. Various mathematical formalisms may be used to express and tackle combinatorial problems, among them the constraint satisfaction problem (CSP) and the propositional satisfiability problem (SAT). These algorithms, or constraint solvers, apply search space reduction through inference techniques, use activity-based heuristics to guide exploration, diversify the searches through frequent restarts, and often learn from their mistakes. In this book the author focuses on knowledge sharing in combinatorial search, the capacity to generate and exploit meaningful information, such as redundant constraints, heuristic hints, and performance measures, during search, which can dramatically improve the performance of a constraint solver. Information can be shared between multiple constraint solvers simultaneously working on the same instance, or information can help achieve good performance while solving a large set of related instances. In the first case, information sharing has to be performed at the expense of the underlying search effort, since a solver has to stop its main effort to prepare and commu nicate the information to other solvers; on the other hand, not sharing information can incur a cost for the whole system, with solvers potentially exploring unfeasible spaces discovered by other solvers. In the second case, sharing performance measures can be done with little overhead, and the goal is to be able to tune a constraint solver in relation to the characteristics of a new instance - this corresponds to the selection of the most suitable algorithm for solving a given instance. The book is suitable for researchers, practitioners, and graduate students working in the areas of optimization, search, constraints, and computational complexity.

Presenting a study of geometric action functionals (i.e., non-negative functionals on the space of unparameterized oriented rectifiable curves), this monograph focuses on the subclass of those functionals whose local action is a degenerate type of Finsler metric that may vanish in certain directions, allowing for curves with positive Euclidean length but with zero action. For such functionals, criteria are developed under which there exists a minimum action curve leading from one given set to another. Then the properties of this curve are studied, and the non-existence of minimizers is established in some settings. Applied to a geometric reformulation of the quasipotential of Wentzell-Freidlin theory (a subfield of large deviation theory), these results can yield the existence and properties of maximum likelihood transition curves between two metastable states in a stochastic process with small noise. The book assumes only standard knowledge in graduate-level analysis; all higher-level mathematical concepts are introduced along the way.

The book presents applications of stochastic calculus to derivative security pricing and interest rate modelling. By focusing more on the financial intuition of the applications rather than the mathematical formalities, the book provides the essential knowledge and understanding of fundamental concepts of stochastic finance, and how to implement them to develop pricing models for derivatives as well as to model spot and forward interest rates. Furthermore an extensive overview of the associated literature is presented and its relevance and applicability are discussed. Most of the key concepts are covered including Ito's Lemma, martingales, Girsanov's theorem, Brownian motion, jump processes, stochastic volatility, American feature and binomial trees. The book is beneficial to higher-degree research students, academics and practitioners as it provides the elementary theoretical tools to apply the techniques of stochastic finance in research or industrial problems in the field.

Victor Isakov This volume contains various results on partial di?erential equations where Sobolev spaces are used. Their selection is motivated by the research int- ests of the editor and the geographicallinks to the places where S. L. Sobolev worked and lived: St. Petersburg, Moscow, and Novosibirsk. Most of the papers are written by leading experts in control theory and inverse pr- lems. Another reason for the selection is a strong link to applied areas. In my opinion, control theory and inverse problems are main areas of di?er- tial equations of importance for some branches of contemporary science and engineering. S. L. Sobolev, as many great mathematicians, was very much motivated by applications. He did not distinguished between pure and - plied mathematics, but, in his own words, between "good mathematics and bad mathematics. " While he possessed a brilliant analytical technique, he most valued innovative ideas, solutions of deep conceptual problems, and not mathematical decorations, perfecting exposition, and "generalizations. " S. L. Sobolev himself never published papers on inverse problems or c- trol theory, but he was very much aware of the state of art and he monitored research on inverse problems. In particular, in his lecture at a Conference on Di?erentialEquationsin1954(found inSobolev'sarchiveandmadeavailable to me by Alexander Bukhgeim), he outlined main inverse problems in g- physics: theinverseseismicproblem, theelectromagneticprospecting, andthe inverse problem of gravimetry.

This book shows how the use of S-variables (SVs) in enhancing the range of problems that can be addressed with the already-versatile linear matrix inequality (LMI) approach to control can, in many cases, be put on a more unified, methodical footing. Beginning with the fundamentals of the SV approach, the text shows how the basic idea can be used for each problem (and when it should not be employed at all). The specific adaptations of the method necessitated by each problem are also detailed. The problems dealt with in the book have the common traits that: analytic closed-form solutions are not available; and LMIs can be applied to produce numerical solutions with a certain amount of conservatism. Typical examples are robustness analysis of linear systems affected by parametric uncertainties and the synthesis of a linear controller satisfying multiple, often  conflicting, design specifications. For problems in which LMI methods produce conservative results, the SV approach is shown to achieve greater accuracy. The authors emphasize the simplicity and easy comprehensibility of the SV approach and show how it can be implemented in programs without difficulty so that its power becomes readily apparent. The S-variable Approach to LMI-based Robust Control is a useful reference for academic control researchers, applied mathematicians and graduate students interested in LMI methods and convex optimization and will also be of considerable assistance to practising control engineers faced with problems of conservatism in their systems and controllers.

This special volume is a collection of outstanding more applied articles presented in AMAT 2015 held in Ankara, May 28-31, 2015, at TOBB Economics and Technology University. The collection is suitable for Applied and Computational Mathematics and Engineering practitioners, also for related graduate students and researchers. Furthermore it will be a useful resource for all science and engineering libraries. This book includes 29 self-contained and well-edited chapters that can be among others useful for seminars in applied and computational mathematics, as well as in engineering.

Optimal analysis is defined as an analysis that creates and uses sparse, well-structured and well-conditioned matrices. The focus is on efficient methods for eigensolution of matrices involved in static, dynamic and stability analyses of symmetric and regular structures, or those general structures containing such components. Powerful tools are also developed for configuration processing, which is an important issue in the analysis and design of space structures and finite element models. Different mathematical concepts are combined to make the optimal analysis of structures feasible. Canonical forms from matrix algebra, product graphs from graph theory and symmetry groups from group theory are some of the concepts involved in the variety of efficient methods and algorithms presented. The algorithms elucidated in this book enable analysts to handle large-scale structural systems by lowering their computational cost, thus fulfilling the requirement for faster analysis and design of future complex systems. The value of the presented methods becomes all the more evident in cases where the analysis needs to be repeated hundreds or even thousands of times, as for the optimal design of structures by different metaheuristic algorithms. The book is of interest to anyone engaged in computer-aided analysis and design and software developers in this field. Though the methods are demonstrated mainly through skeletal structures, continuum models have also been added to show the generality of the methods. The concepts presented are not only applicable to different types of structures but can also be used for the analysis of other systems such as hydraulic and electrical networks.

This book opens new avenues in understanding mathematical models within the context of a transition economy. The exposition lays out the methods for combining different mathematical structures and tools to effectively build the next model that will accurately reflect real world economic processes. Mathematical modeling of weather phenomena allows us to forecast certain essential weather parameters without any possibility of changing them. By contrast, modeling of transition economies gives us the freedom to not only predict changes in important indexes of all types of economies, but also to influence them more effectively in the desired direction. Simply put: any economy, including a transitional one, can be controlled. This book is useful to anyone who wants to increase profits within their business, or improve the quality of their family life and the economic area they live in. It is beneficial for undergraduate and graduate students specializing in the fields of Economic Informatics, Economic Cybernetics, Applied Mathematics and Large Information Systems, as well as for professional economists, and employees of state planning and statistical organizations.

This book describes how evolutionary algorithms (EA), including genetic algorithms (GA) and particle swarm optimization (PSO) can be utilized for solving multi-objective optimization problems in the area of embedded and VLSI system design. Many complex engineering optimization problems can be modelled as multi-objective formulations. This book provides an introduction to multi-objective optimization using meta-heuristic algorithms, GA and PSO and how they can be applied to problems like hardware/software partitioning in embedded systems, circuit partitioning in VLSI, design of operational amplifiers in analog VLSI, design space exploration in high-level synthesis, delay fault testing in VLSI testing and scheduling in heterogeneous distributed systems. It is shown how, in each case, the various aspects of the EA, namely its representation and operators like crossover, mutation, etc, can be separately formulated to solve these problems. This book is intended for design engineers and researchers in the field of VLSI and embedded system design. The book introduces the multi-objective GA and PSO in a simple and easily understandable way that will appeal to introductory readers.