Abiotic Stress and Legumes: Tolerance and Management is the first book to focus on the ability of legume plants to adapt effectively to environmental challenges. Using the -omic approach, this book takes a targeted approach to understanding the methods and means of ensuring survival and maximizing the productivity of the legume plant by improving tolerance to environmental /abiotic stress factors including drought, temperature change, and other challenges. The book presents a comprehensive overview of the progress that has been made in identifying means of managing abiotic stress effects, specifically in legumes, including the development of several varieties which exhibit tolerance through high yield using transcriptomic, proteomic, metabolomic and ionomic approaches. Further, exogenous application of various stimulants such as plant hormones, nutrients, sugars, and polyamines has emerged as an alternative strategy to improve productivity under these environmental challenges. Abiotic Stress and Legumes: Tolerance and Management examines these emerging strategies and serves as an important resource for researchers, academicians and scientists, enhancing their knowledge and aiding further research.

Titanium Alloys for Biomedical Development and Applications: Design, Microstructure, Properties and Application systematically introduces basic theories and progress in the research of biomedical ss-Ti alloys achieved by researchers from different fields. It focuses on a high-strength and low elastic modulus biomedical ss-Ti alloy (TLM), etc. designed by the authors. The alloy design methods, microstructural characteristics, mechanical properties, surface treatment methods and biocompatibility of the TLM alloy are discussed in detail, along with a concise description of the medical devices made from this alloy and the application examples. This book will appeal to researchers as well as students from different disciplines, including materials science, biology, medicine and engineering fields.

Biomedical Applications of Electrospinning and Electrospraying describes the principles and laboratory set up for electrospinning and electrospraying, addressing a range of biomedical applications. Sections cover novel combinational approaches, such as electrospinning/spraying and 3D printing. Electrospinning has evolved from being a technique to prepare random networks of textile fibers to a technique to fabricate highly ordered patterns of biomedical materials of defined scale. The technological advancements in recent years with regard to the way the jet is facilitated, how the jet path is controlled, and how the fibers are collected have provided invaluable insights into controlled fabrication of a material of choice. Additionally, the electrospray technique has also evolved from being a technique to prepare food formulations to a technique to prepare cell encapsulated beads for transplantation in clinics. Several innovations in this line, such as those leading to core-shell materials have tremendously changed the way the technique is used. Thus, a combinational approach using electrospinning, electrospraying and 3D printing has emerged.

Advances in Applied Microbiology, Volume 116 continues the comprehensive reach of this widely read and authoritative review source in microbiology. Users will find invaluable references and information on a variety of areas relating to the topic of microbiology, with this release focusing on the lipid production by oleaginous yeasts.

Bioleaching of chalcopyrite is always a challenge and research hotspot. The low copper extraction and dissolution kinetics restricted the industrial application of chalcopyrite bioleaching. To solve this problem, the dissolution process and passivation mechanism of chalcopyrite in bioleaching should be first studied, then the rate-limiting steps should be analysed explicitly, and finally the intensifying method can be put forward. Many scholars have made efforts to investigate the dissolution mechanism of chalcopyrite in bioleaching. However, there is no congruence of opinion as yet. Biohydrometallurgy of Chalcopyrite summarizes and discusses the reported research findings. In addition, this book publishes the related results found by the authors' research. Then, the dissolution mechanism of chalcopyrite in bioleaching is interpreted. Finally, the process intensification techniques of chalcopyrite bioleaching are provided and discussed. Hence, this book provides useful reference and guidance in both laboratory research and industrial production.

Modern Practical Healthcare Issues in Biomedical Instrumentation describes the designs, applications and principles of several medical devices used in hospitals and at home. The book presents practical devices that can potentially be used for healthcare purposes. Sections cover the use of biosensors to monitor the physiological properties of the human body, focusing on devices used to evaluate, measure and manipulate the biological system, and highlighting practical devices that can potentially be used for healthcare purposes. It is an excellent resource for undergraduate, graduate and post-graduate students of biomedical engineering.

Microbial Extremozymes: Novel Sources and Industrial Applications is a unique resource of practical research information on the latest novel sources and technologies regarding extremozymes in bioremediation, waste management, valorization of industrial by-products, biotransformation of natural polymers, nutrition, food safety and diagnosis of disease. The book's broad knowledge and varying applications are useful to the food industry, dairy industry, fruit and vegetable processing, and baking and beverages industries, as well as the pharmaceutical and biomedical industries. This is a concise, all-encompassing resource for a range of scientists needing knowledge of extremozymes to enhance and research. Furthermore, it provides an updated knowledge of microbial enzymes isolated from extreme environments (temperatures, etc.) and their biotechnological applications. It will be useful to researchers, scientists and students in enzyme research. In addition, users from the dairy and baking industries will benefit from the presented content.

Micro and Nano Systems for Biophysical Studies of Cells and Small Organisms provides a comprehensive introduction to the state-of-the-art micro and nano systems that have recently been developed and applied to biophysical studies of cells and small organisms. These micro and nano systems span from microelectromechanical systems (MEMS) and microfluidic devices to robotic micro-nanomanipulation systems. These biophysical studies range from cell mechanics to the neural science of worms and Drosophila. This book will help readers understand the fundamentals surrounding the development of these tools and teach them the most recent advances in cellular and organismal biophysics enabled by these technologies.

Wild Germplasm for Genetic Improvement in Crop Plants addresses the need for an integrated reference on a wide variety of crop plants, facilitating comparison and contrast, as well as providing relevant relationships for future research and development. The book presents the genetic and natural history value of wild relatives, covers what wild relatives exist, explores the existing knowledge regarding specific relatives and the research surrounding them and identifies knowledge gaps. As understanding the role of crop wild relatives in plant breeding expands the genetic pool for abiotic and biotic stress resistance, this is an ideal reference on this important topic.

Polysaccharide-Based Nanocomposites for Gene Delivery and Tissue Engineering presents quantitative background on new polysaccharide nanocomposites in a clear and logical way, highlighting the most exciting applications in gene delivery and tissue engineering and their progress. The book focuses on the different types of polysaccharide nanocomposites for gene delivery and tissue engineering and covers polysaccharide hydrogels for tissue engineering and polysaccharide magnetic nanocomposites for gene delivery. Chapters cover various nanocomposites presented in twenty-one separate chapters. This book will be of great interest to all those researching the development and applications of polysaccharide-based nanocomposites for modeling. As polysaccharide-based nanocomposites promise cutting-edge applications in gene delivery and tissue engineering, with their development at the forefront of modern medicine, this book is a welcome title on this exciting science.

Autonomous Robot-Aided Optical Manipulation for Biological Cells gives a systematically and almost self-contained description of the many facets of modeling, sensing, and control techniques or experimentally exploring emerging trends in optical manipulation of biological cell in micro/nanorobotics systems. To achieve biomedical applications, reliability design, modeling, and precision control are vitally important for the development of engineering systems. With the advances in modeling, sensing, and control techniques, it is opportunistic to exploit them for the benefit of reliability design, actuation, and precision control of micro/nanomanipulation systems to expanding the applications of robot at the micro and nano scales, especially in biomedical engineering. This book presents new techniques in reliability modeling and advanced control of robot-aided optical manipulation of biological cells systems. The book will be beneficial to the researchers within robotics, mechatronics, biomedical engineering, and automatic control society, including both academic and industrial parts.

Nanotechnology in Conservative Dentistry provides a detailed review of the use of nanotechnology in conservative dentistry, from diagnosis and restorative materials, through to tissue engineering and regeneration. This book covers fundamental topics in the field of conservative dentistry, including caries therapy, dentin reconstruction, pulp protection and more; each chapter reviews and discusses how nanotechnology can be implemented as a novel approach to traditional conservative dentistry techniques, exploring the many uses and advantages of this fast-growing technology. Various nanobiomaterials and technologies are covered, as well as assessment of the biocompatibility and toxicological risks of utilizing nanotechnology in dentistry. Nanotechnology in Conservative Dentistry will help dentists and materials science academics alike, understand the potential of nanotechnology in dentistry, building on and going beyond traditional concepts and techniques in this field.

Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an "inert" immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition. There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response. The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines.

Bioinspired and Biomimetic Materials for Drug Delivery delves into the potential of bioinspired materials in drug delivery, detailing each material type and its latest developments. In the last decade, biomimetic and bioinspired materials and technology has garnered increased attention in drug delivery research. Various material types including polymer, small molecular, protein, peptide, cholesterol, polysaccharide, nano-crystal and hybrid materials are widely considered in drug delivery research. However, biomimetic and bioinspired materials and technology have shown promising results for use in therapeutics, due to their high biocompatibility and reduced immunogenicity. Such materials include dopamine, extracellular exosome, bile acids, ionic liquids, and red blood cell. This book covers each of these materials in detail, reviewing their potential and usage in drug delivery. As such, this book will be a great source of information for biomaterials scientists, biomedical engineers and those working in pharmaceutical research.

Herbal Biomolecules in Healthcare Applications presents extensive detailed information on all the vital principles, basics and fundamental aspects of multiple herbal biomolecules in the healthcare industry. This book examines important herbal biomolecules including alkaloids, glycosides, flavonoids, anthraquinones, steroids, polysaccharides, tannins and polyphenolic compounds, terpenes, fats and waxes, proteins and peptides, and vitamins. These herbal biomacromolecules are responsible for different bioactivities as well as pharmacological potentials. A systematic understanding of the extraction, purification, characterization, applications of these herbal biomolecules and their derivatives in healthcare fields is developed in this comprehensive book. Chapters explore the key topics along with an emphasis on recent research and developments in healthcare fields by leading experts. They include updated literature review of the relevant key topics, good quality illustrations, chemical structures, flow charts, well-organized tables and case studies. Herbal Biomolecules in Healthcare Applications will be useful for researchers working on natural products and biomolecules with bioactivity and nutraceutical properties. Professionals specializing in scientific areas such as biochemistry, pharmacology, analytical chemistry, organic chemistry, clinics, or engineering focused on bioactive natural products will find this book useful.

Innovation Strategies for the Food Industry: Tools for Implementation, Second Edition explores how process technologies and innovations are implemented in the food industry, by i.e., detecting problems and providing answers to questions of modern applications. As in all science sectors, Internet and big data have brought a renaissance of changes in the way academics and researchers communicate and collaborate, and in the way that the food industry develops. The new edition covers emerging skills of food technologists and the integration of food science and technology knowledge into the food chain. This handbook is ideal for all relevant actors in the food sector (professors, researchers, students and professionals) as well as for anyone dealing with food science and technology, new products development and food industry.

Lignin-based Materials for Biomedical Applications: Preparation, Characterization, and Implementation explores the emerging area of lignin-based materials as a platform for advanced biomedical applications, guiding the reader from source through to implementation. The first part of the book introduces the basics of lignin, including extraction methods, chemical modifications, structure and composition, and properties that make lignin suitable for biomedical applications. In addition, structural characterization techniques are described in detail. The next chapters focus on the preparation of lignin-based materials for biomedical applications, presenting methodologies for lignin-based nanoparticles, hydrogels, aerogels, and nanofibers, and providing in-depth coverage of lignin-based materials with specific properties-including antioxidant properties, UV absorbing capability, antimicrobial properties, and colloidal particles with tailored properties-and applications, such as drug and gene delivery, and tissue engineering. Finally, future perspectives and possible new applications are considered. This is an essential reference for all those with an interest in lignin-based materials and their biomedical applications, including researchers and advanced students across bio-based polymers, polymer science, polymer chemistry, biomaterials, nanotechnology, materials science and engineering, drug delivery, and biomedical engineering, as well as industrial R&D and scientists involved with bio-based polymers, specifically for biomedical applications.

Sustainable Biofuels: Opportunities and challenges, a volume in the "Applied Biotechnology Reviews" series, explores the state-of-the-art in research and applied technology for the conversion of all types of biofuels. Its chapters span a broad spectrum of knowledge, from fundamentals and technical aspects to optimization, combinations, economics, and environmental aspects. They cover various facets of research, production, and commercialization of bioethanol, biodiesel, biomethane, biohydrogen, biobutanol, and biojet fuel. This book discusses biochemical, thermochemical, and hydrothermal conversion of unconventional feedstocks, including the role of biotechnology applications to achieve efficiency and competitiveness. Through case studies, techno-economic analysis and sustainability assessment, including life cycle assessment, it goes beyond technical aspects to provides actual resources for better decision-making during the development of commercially viable technology by researchers, PhD students, and practitioners in the field of bioenergy. It is also a useful resource for those in adjacent areas, such as biotechnology, industrial microbiology, chemical engineering, environmental engineering, and sustainability science, who are working on solutions for the bioeconomy. The ability to compare different technologies and their outcome that this book provides is also beneficial for energy analysts, consultants, planners, and policy-makers. The "Applied Biotechnology Reviews" series highlights current development and research in biotechnology-related fields, combining in single-volume works the theoretical aspects and real-world applications for better decision-making.

Advances in Applied Microbiology, Volume 115 continues the comprehensive reach of this widely read and authoritative review source in microbiology. Users will find invaluable references and information on a variety of areas relating to the topic of microbiology, with this release focusing on the preparation of functional oligosaccharides using microbial coupling fermentation.

Bionanocomposites in Tissue Engineering and Regenerative Medicine explores novel uses of these in tissue engineering and regenerative medicine. This book offers an interdisplinary approach, combining chemical, biomedical engineering, materials science and pharmacological aspects of the characterization, synthesis and application of bionanocomposites. Chapters cover a broad selection of bionanocomposites including chitosan, alginate and more, which are utilized in tissue engineering, wound healing, bone repair, drug formulation, cancer therapy, drug delivery, cartilage regeneration and dental implants. Additional sections of Bionanocomposites in Tissue Engineering and Regenerative Medicine discuss, in detail, the safety aspects and circular economy of bionanocomposites - offering an insight into the commercial and industrial aspects of these important materials. Bionanocomposites in Tissue Engineering and Regenerative Medicine will prove a highly useful text for for those in the fields of biomedical engineering, chemistry, pharmaceutics and materials science, both in academia and industrial R&D groups.

Demystifying Big Data, Machine Learning, and Deep Learning for Healthcare Analytics presents the changing world of data utilization, especially in clinical healthcare. Various techniques, methodologies, and algorithms are presented in this book to organize data in a structured manner that will assist physicians in the care of patients and help biomedical engineers and computer scientists understand the impact of these techniques on healthcare analytics. The book is divided into two parts: Part 1 covers big data aspects such as healthcare decision support systems and analytics-related topics. Part 2 focuses on the current frameworks and applications of deep learning and machine learning, and provides an outlook on future directions of research and development. The entire book takes a case study approach, providing a wealth of real-world case studies in the application chapters to act as a foundational reference for biomedical engineers, computer scientists, healthcare researchers, and clinicians.

Microfluidic Devices for Biomedical Applications, Second Edition provides updated coverage on the fundamentals of microfluidics, while also exploring a wide range of medical applications. Chapters review materials and methods, microfluidic actuation mechanisms, recent research on droplet microfluidics, applications in drug discovery and controlled-delivery, including micro needles, consider applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds, and cover the applications of microfluidic devices in diagnostic sensing, including genetic analysis, low-cost bioassays, viral detection, and radio chemical synthesis. This book is an essential reference for medical device manufacturers, scientists and researchers concerned with microfluidics in the field of biomedical applications and life-science industries.

Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index. This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations. Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer.

Structural Biomaterials: Properties, Characteristics, and Selection serves as a single point of reference to digest current research and develop a deeper understanding in the field of biomaterials engineering. This book uses a materials-focused approach, allowing the reader to quickly access specific, detailed information on biomaterials characterization and selection. Relevant to a range of readers, this book provides holistic coverage of the broad categories of structural biomaterials currently available and used in medical applications, highlighting the property requirements for structural biomaterials, their biocompatibility performance and their safety regulation in key categories such as metals, ceramics and polymers. The materials science perspective of this text ensures the content is accessible even to those without an extensive background in applied medicine, positioning this text not just for students, but as an overview and reference for researchers, scientists and engineers entering the field from related materials science disciplines.