"Algae are mysterious and fascinating organisms that hold great potential for discovery and biotechnology." -Dr. Thierry Tonon, Department of Biology, University of York "Science is a beautiful gift to humanity; we should not distort it." -A.P.J. Abdul Kalam In this book, we emphasise the importance of algal biotechnology as a sustainable platform to replace the conventional fossil-based economy. With this focus, Volume 2 summarizes up-to-date literature knowledge and discusses the advances in algal cultivation, genetic improvement, wastewater treatment, resource recovery, commercial operation, and technoeconomic analysis of algal biotechnology. FEATURES Discusses in detail recent developments in algae cultivation and biomass harvesting Provides an overview of genetic engineering and algal-bacteria consortia to improve productivity Presents applications of algae in the area of wastewater treatment and resource recovery Provides case studies and technoeconomic analysis to understand the algal biorefinery Shashi Kant Bhatia, PhD, is an Associate Professor in the Department of Biological Engineering, Konkuk University, Seoul, South Korea. Sanjeet Mehariya, PhD, is a Postdoctoral Researcher in the Department of Chemistry, Umea University, Umea, Sweden. Obulisamy Parthiba Karthikeyan, PhD, is a Research Scientist and Lecturer (Adjunct) in the Department of Civil and Environmental Engineering, South Dakota School of Mines and Technology, Rapid City, South Dakota, USA.

General compendium of HDAC inhibitors with deep emphasis on toxicity issues of synthetic HDAC inhibitors Various groups of natural HDAC inhibitors, their representatives and premier sources Cyclic tetrapeptides of natural origin and their importance as cancer chemotherapeutic agents Hydroxamates and depsipeptides from natural sources and their promising role in cancer therapy Natural Flavonoids, their HDAC inhibitory tendency and marvellous anticancer activity Non-flavonoid natural HDAC inhibitors and their pleasing cytotoxic effects towards cancer models Combined therapy involving natural flavonoids with other anticancer molecules for synergistic and additive benefits against cancer models Non-flavonoid HDAC inhibitors and conventional drugs in collaborative mode against aggressive malignancies Nanotechnology based delivery of natural HDAC inhibitors for greater therapeutic efficacy over traditional combinatorial therapy

Directs the attention to the smart digital healthcare system in this COVID-19 pandemic. Simulates novel investigations and how they will be beneficial in understanding the pandemic. Presents the latest ideas developed for data scientists, doctors, engineers, and economists. Analyses the various issues related to computing, AI apps, big data analytic techniques, and predictive scientific skill gaps. Explains some interesting and diverse types of challenges and data-driven healthcare applications.

This book provides a well-focused and comprehensive overview of novel technologies involved in advanced microfluidics based diagnosis via various types of prognostic and diagnostic biomarkers. This authors examine microfluidics based diagnosis in the biomedical field as an upcoming field with extensive applications. It provides a unique approach and comprehensive technology overview for diagnosis management towards early stages of various bioanalytes via cancer diagnostics diabetes, alzheimer disease, toxicity in food products, brain and retinal diseases, cardiovascular diseases, and bacterial infections etc. Thus, this book would encompass a combinatorial approach of medical science, engineering and biomedical technology. The authors provide a well-focused and comprehensive overview of novel technologies involved in advanced microfluidics based diagnosis via various types of prognostic and diagnostic biomarkers. Moreover, this book contains detailed description on the diagnosis of novel techniques. This book would serve as a guide for students, scientists, researchers, and microfluidics based point of care technologies via smart diagnostics and to plan future research in this valuable field.

This book is designed as a reference book and presents a systematic approach to analyze evolutionary and nature-inspired population-based search algorithms. Beginning with an introduction to optimization methods and algorithms and various enzymes, the book then moves on to provide a unified framework of process optimization for enzymes with various algorithms. The book presents current research on various applications of machine learning and discusses optimization techniques to solve real-life problems. The book compiles the different machine learning models for optimization of process parameters for production of industrially important enzymes. The production and optimization of various enzymes produced by different microorganisms are elaborated in the book It discusses the optimization methods that help minimize the error in developing patterns and classifications, which further helps improve prediction and decision-making Covers the best-performing methods and approaches for optimization sustainable enzymes production with AI integration in a real-time environment Featuring valuable insights, the book helps readers explore new avenues leading towards multidisciplinary research discussions The book is aimed primarily at advanced undergraduates and graduates studying machine learning, data science and industrial biotechnology. Researchers and professionals will also find this book useful.

The scope of opportunities in chemical and biomolecular engineering has grown tremendously in recent years. Careers in Chemical and Biomolecular Engineering conveys the breadth and depth of today's chemical and biomolecular engineering practice, and describes the intellectually enriching, socially conscious and financially lucrative opportunities available for such graduates in an ever-widening array of industries and applications. This book aims to help students interested in studying chemical engineering and biomolecular engineering to understand the many potential career pathways that are available in these dynamic fields - and is an indispensable resource for the parents, teachers, advisors and guidance counselors who support them, In addition to 10 chapters that discuss the roles such graduates play in many diverse industries, this book also features 25 Profile articles that share in-depth, first-person insight from industry-leading chemical and biomolecular engineers. These technical professionals discuss their work and educational experiences (in terms of both triumphs and challenges), and share wisdom and recommendations for students pursuing these two dynamic engineering disciplines.

The Textbook of Ion Channels is a set of three volumes that provides a wide-ranging reference source on ion channels for students, instructors, and researchers. Ion channels are membrane proteins that control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli like light, sound, odor, and taste, and regulate the response to physical stimuli like temperature and pressure. In non-excitable tissues, ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells, giving them the unique ability to communicate with the environment, as well as the membrane of intracellular organelles, allowing them to regulate internal homeostasis. Ion channels are fundamentally important for human health and diseases, and are important targets for pharmaceuticals in mental illness, heart disease, anesthesia, pain and other clinical applications. The modern methods used in their study are powerful and diverse, ranging from single ion-channel measurement techniques to models of ion channel diseases in animals, and human clinical trials for ion channel drugs. Volume II starts with ion channel taxonomy and features coverage of major ion channel families and describes the physiological role, structural components, gating mechanisms and biophysics, permeation and selectivity, regulation, pharmacology and roles in disease mechanisms. Channels in this volume include voltage-activated sodium, calcium and potassium channels, inward-rectifier and two-pore domain potassium channels, calcium-activated potassium channels, cyclic-nucleotide gated channels, pacemaker ion channels, chloride channels, the ligand-gated receptors activated by acetylcholine, glutamate, 5-HT3, GABA and glycine, acid-sensing channels, P2X receptors, TRP channels, store-operated channels, pressure-activated piezo channels, ryanodine receptors and proton channels. All three volumes give the reader an introduction to fundamental concepts needed to understand the mechanism of ion channels, a guide to the technical aspects of ion channel research, offer a modern guide to the properties of major ion channel families, and include coverage of key examples of regulatory, physiological, and disease roles for ion channels.

The Textbook of Ion Channels is a set of three volumes that provides a wide-ranging reference source on ion channels for students, instructors, and researchers. Ion channels are membrane proteins that control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli like light, sound, odor, and taste, and regulate the response to physical stimuli like temperature and pressure. In non-excitable tissues, ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells, giving them the unique ability to communicate with the environment, as well as the membrane of intracellular organelles, allowing them to regulate internal homeostasis. Ion channels are fundamentally important for human health and diseases, and are important targets for pharmaceuticals in mental illness, heart disease, anesthesia, pain and other clinical applications. The modern methods used in their study are powerful and diverse, ranging from single ion-channel measurement techniques to models of ion channel diseases in animals, and human clinical trials for ion channel drugs. Volume III includes coverage of key ion channel regulators and their mechanisms, the role of ion channels working in concert in selected physiological systems, and examples of ion channel mutations and dysfunction in a selection of diseases. Chapters on ion channel regulation include splice variants, calcium-calmodulin regulation, regulation by G-proteins, and lipids. A selection of ion channels in physiological systems includes ion channels of the heart, ion channels in immune cells and their role in pancreatic beta cells and regulation of insulin secretion, and the role of channels in sperm and eggs. While disease mechanisms are integrated into the chapters of Volume II, Volume III offers special consideration of ion channels in epilepsy, cystic fibrosis, and pain syndromes. All three volumes give the reader an introduction to fundamental concepts needed to understand the mechanism of ion channels, a guide to the technical aspects of ion channel research, offer a modern guide to the properties of major ion channel families, and include coverage of key examples of regulatory, physiological, and disease roles for ion channels.

As medical devices become even more intricate, concerns about efficacy, safety, and reliability continue to be raised. Users and patients both want the device to operate as specified, perform in a safe manner, and continue to perform over a long period of time without failure. Following in the footsteps of the bestselling second edition, Reliable Design of Medical Devices, Third Edition shows you how to improve reliability in the design of advanced medical devices. Reliability engineering is an integral part of the product development process and of problem-solving activities related to manufacturing and field failures. Mirroring the typical product development process, the book is organized into seven parts. After an introduction to the basics of reliability engineering and failures, it takes you through the concept, feasibility, design, verification and validation, design transfer and manufacturing, and field activity phases. Topics covered include Six Sigma for design, human factors, safety and risk analysis, and new techniques such as accelerated life testing (ALT) and highly accelerated life testing (HALT). What's New in This Edition Updates throughout, reflecting changes in the field An updated software development process Updated hardware test procedures A new layout that follows the product development process A list of deliverables needed at the end of each development phase Incorporating reliability engineering as a fundamental design philosophy, this book shares valuable insight from the author's more than 35 years of experience. A practical guide, it helps you develop a more effective reliability engineering program-contributing to increased profitability, more satisfied customers, and less risk of liability.

The best source for cutting-edge insights into AI in healthcare operations AI in Healthcare: How Artificial Intelligence Is Changing IT Operations and Infrastructure Services collects, organizes and provides the latest, most up-to-date research on the emerging technology of artificial intelligence as it is applied to healthcare operations. Written by a world-leading technology executive specializing in healthcare IT, this book provides concrete examples and practical advice on how to deploy artificial intelligence solutions in your healthcare environment. AI in Healthcare reveals to readers how they can take advantage of connecting real-time event correlation and response automation to minimize IT disruptions in critical healthcare IT functions. This book provides in-depth coverage of all the most important and central topics in the healthcare applications of artificial intelligence, including: Healthcare IT AI Clinical Operations AI Operational Infrastructure Project Planning Metrics, Reporting, and Service Performance AIOps in Automation AIOps Cloud Operations Future of AI Written in an accessible and straightforward style, this book will be invaluable to IT managers, administrators, and engineers in healthcare settings, as well as anyone with an interest or stake in healthcare technology.

Drawing on contributions from more than thirty scholars and experts in the field, this book examines the role of business as an enabler, as an inhibitor, and ultimately as a co-actor in global sustainability transformations expected over the next few decades. The Role of Business in Global Sustainability Transformations employs several theoretical perspectives and provides abundant examples and cases to discuss a variety of emerging concepts, phenomena, and trends shaping business sustainability. Weaving through the chapters, the editors present core tensions and sources of inertia towards transformative change, and acknowledge that envisioning multiple solutions and pathways are possible and desirable. They advocate for the need to align visions, actions and time horizons between policy, society and business in addressing the interlinked socio-ecological challenges that our society currently faces. This book will be an important resource for scholars and professionals working in the field of sustainability and sustainable business, and a vital educational text for students interested in this discipline.

The book is an introduction to nanomedicine informed by a philosophical reflection about the domain and recent developments. It is an overview of the field, sketching out the main areas of current investment and research. The authors present some case-studies illustrating the different areas of research (nanopharmacy, theranostics and patient monitoring) as well as reflecting on the risks that accompany it, such as unanticipated impacts on human health and environmental toxicity. This introduction to a fast-growing field in modern medical research is of great interest to researchers working in many disciplines as well as the general public. In addition to an overview of the work currently ongoing, the authors critically assess these projects from an ethical and philosophical perspective. Key Features Provides an overview of nanomedicine Employs a reflective and coherent critical evaluation of the benefits and risks of nanomedicine Written in an accessible manner intended for a wide audience Related Titles Hehenberger, M. Nanomedicine: Science, Business, and impact (ISBN 978-9-8146-1376-7). Beg, S., et al. Nanomedicine for the treatment of Disease: From Concept to Application (ISBN 978-1-7746-3443-1) Brenner, S. The Clinical Nanomedicine Handbook (ISBN 978-1-1380-7578-8)

The book is an introduction to nanomedicine informed by a philosophical reflection about the domain and recent developments. It is an overview of the field, sketching out the main areas of current investment and research. The authors present some case-studies illustrating the different areas of research (nanopharmacy, theranostics and patient monitoring) as well as reflecting on the risks that accompany it, such as unanticipated impacts on human health and environmental toxicity. This introduction to a fast-growing field in modern medical research is of great interest to researchers working in many disciplines as well as the general public. In addition to an overview of the work currently ongoing, the authors critically assess these projects from an ethical and philosophical perspective. Key Features Provides an overview of nanomedicine Employs a reflective and coherent critical evaluation of the benefits and risks of nanomedicine Written in an accessible manner intended for a wide audience Related Titles Hehenberger, M. Nanomedicine: Science, Business, and impact (ISBN 978-9-8146-1376-7). Beg, S., et al. Nanomedicine for the treatment of Disease: From Concept to Application (ISBN 978-1-7746-3443-1) Brenner, S. The Clinical Nanomedicine Handbook (ISBN 978-1-1380-7578-8)

Biomimetics is based on nature, while technology is based on economy. One of the solutions for a sustainable society is to learn a grand design of technology from nature. Methods that mimic nature have a long history in various fields. Now is the time to use biomimetics as a starting technology design. Biomimetics is gaining a great deal of attention not only in materials and mechanical engineering but also in the ecosystem that comprises city planning, agriculture, and forestry. Informatics is being added to biomimetics to support its diversity and cross-disciplinarity. This book will inspire the undergraduate and graduate students, researchers, and general readers who aim to develop technology for sustainability. Edited by Profs Akihiro Miyauchi and Masatsugu Shimomura, two prominent nanotechnology researchers, the book is their second volume on biomimetics. The first volume, Industrial Biomimetics, also published by Jenny Stanford Publishing, focused on the engineering aspect of biomimetics.

This book highlights the characteristics, aims, and applications of bionanotechnology as a possible solution for sustainable management and bioremediation of environmental pollutants. It covers remediation of toxic pollutants, removal of emerging contaminants from industrial wastewater, eco-design and modification study of bio-nanoparticles and life-cycle assessment, nano-filtration, bio-nanomaterials based sensors for monitoring air and water pollution, resource recovery from wastewater, and highlights Internet of things-based green nanotechnology. Provides a comprehensive solution of environmental problems in sustainable and cost-effective mode Reviews bionanotechnological applications in nanomaterials design, modification, and treatment of emerging contaminants from industrial wastewater. Covers Eco-design study of bio-nanomaterials, bio-nano filters, and assessment for the treatment of emerging pollutants Includes IoT- based bionanotechnology Explores future research needs on bionanotechnology and scientific challenges in the mitigation of environmental pollutants This book is aimed at researchers, professionals, and graduate students in nanobiotechnology, environmental engineering, biotechnology.

Documents the confused early history of DNA, RNA and proteins - a transformative history of molecular biology like no other. Integrates the influences of biochemistry and genetics on the landscape of molecular biology. Chronicles the important discoveries, preconceptions and misconceptions that retarded or misdirected progress. Highlights major pioneers and contributors to molecular biology, with a focus on RNA and noncoding DNA. Summarizes the mounting evidence for the central roles of non-protein-coding RNA in cell and developmental biology. Provides a thought-provoking retrospective and forward-looking perspective for advanced students and professional researchers.

Covers applications of various image processing techniques in thermal imaging applications for diagnosis of different medical conditions Describes the development of a computer diagnostics system (CAD) based on thermographic data Discusses customized deep learning models for accurate diagnosis of various diseases Includes new aspects in rheumatoid arthritis and diabetes research with usage of advanced analytical tools Reviews application of feature fusion algorithms and feature reduction algorithms for accurate classification of images

1. Discusses implications of COVID on education, environment, and lifestyle 2. Elucidates life-style transformation strategy to counter COVID 3. Focuses on transformative strategy to overcome COVID impact

Develop a healthier connection between worker and work with this practical introduction The United States Bureau of Labor Statistics estimates that 34% of all workdays lost each year are the result of work-related musculoskeletal disorders (WMSDs). These disorders result from a mismatch between a worker, their working conditions, and the task they perform. Improperly designed tasks or equipment, insufficient downtime between shifts or tasks, or even simple sitting position can all produce WMSDs. The key insights into preventing these disorders are produced by ergonomics, the scientific study of human bodies as they relate to objects, systems, and environments, especially work environments. Occupational Ergonomics: A Practical Approach aims to supply an ergonomic toolkit for creating healthier relationships between workers' bodies and their work. Beginning with a set of foundational ergonomic principles, it then details multiple assessment techniques in ways easily adapted to specific workplace situations. This balance of theory and practice has made Occupational Ergonomics an essential reference concerning human beings and the work they do. Readers of the second edition will also find: Up-to-date ergonomic research reflecting the latest clinical and workplace data. Entirely new chapters on Work Physiology, Total Worker Health, Return on Investment, and more. Major revisions to chapters on Elements of an Ergonomic Program, Workstation Design, Work-Related MSDs, How to Conduct an Assessments, and Office Ergonomics Detailed and updated case studies applying ergonomic assessment techniques to common workplace scenarios. Occupational Ergonomics is a must for workplace safety managers, safety coordinators, ergonomics program coordinators, facilities managers, and any professionals concerned with the work environment, and worker health and safety.

This Springer Handbook provides, for the first time, a complete and consistent overview over the methods, applications, and products in the field of marine biotechnology. A large portion of the surface of the earth (ca. 70%) is covered by the oceans. More than 80% of the living organisms on the earth are found in aquatic ecosystems. The aquatic systems thus constitute a rich reservoir for various chemical materials and (bio-)chemical processes. Edited by a renowned expert with a longstanding experience, and including over 60 contributions from leading international scientists, the Springer Handbook of Marine Biotechnology is a major authoritative desk reference for everyone interested or working in the field of marine biotechnology and bioprocessing - from undergraduate and graduate students, over scientists and teachers, to professionals. Marine biotechnology is concerned with the study of biochemical materials and processes from marine sources, that play a vital role in the isolation of novel drugs, and to bring them to industrial and pharmaceutical development. Today, a multitude of bioprocess techniques is employed to isolate and produce marine natural compounds, novel biomaterials, or proteins and enzymes from marine organisms, and to bring them to applications as pharmaceuticals, cosmeceuticals or nutraceuticals, or for the production of bioenergy from marine sources. All these topics are addressed by the Springer Handbook of Marine Biotechnology. The book is divided into ten parts. Each part is consistently organized, so that the handbook provides a sound introduction to marine biotechnology - from historical backgrounds and the fundamentals, over the description of the methods and technology, to their applications - but it can also be used as a reference work. Key topics include: - Marine flora and fauna - Tools and methods in marine biotechnology - Marine genomics - Marine microbiology - Bioenergy and biofuels - Marine bioproducts in industrial applications - Marine bioproducts in medical and pharmaceutical applications - and many more...

Provides a contemporary view of the impact of climate change on cultivation of various fruit species. Offers modern approaches for mitigating the adverse impact of climate change on fruits cultivation. Describes case studies, empirical experiments and observations emphasizing the research progress of understanding and combating the impact of climate change on fruits production. Illustrates presented concepts with relevant figures and tabulated data.

Biohydrogen is a promising gaseous biofuel that has prospective applications in combined heat and power, for fuel cells, or as a precursor for chemicals production. Hydrogen can also be converted to liquid hydrocarbon fuels and value-added chemicals through catalytic thermochemical or through biocatalytic biological pathways. This book covers some the important recent advances in the production and utilization of biohydrogen and its solutions for clean fuel, waste management, waste valorization, reduced greenhouse gas emissions, and climate change mitigation. Biohydrogen: Developments and Prospects first covers the basic principles, benefits, and challenges concerning both the biological and thermochemical routes for biohydrogen production and then goes on to address topics such as biomass conversion to hydrogen through gasification with a focus on the process parameters, catalytic reforming technologies for hydrogen production concerning various feedstocks; the co-conversion of plastic wastes and biomass into biohydrogen through co-gasification technology; the effect of process parameters on syngas yields through co-gasification; fermentative hydrogen production technologies; the molecular mechanism of hydrogen production and enhancing the yield in hydrogen production by genetic and metabolic engineering; hydrogen production routes through microbial electrolysis; and much more. Key features: Helps to provide the most up-to-date information addressing solutions for clean fuel, waste management, waste valorization, reduced greenhouse gas emissions, and climate change mitigation Offers in-depth knowledge about recent developments on thermochemical methanation technologies and bioreactor and bioprocess design in anaerobic digestion technologies Discusses biotechnological interventions for metabolic engineering of microorganisms towards biohydrogen production Looks at gasification technologies and catalytic reforming technologies for hydrogen production Addressing both the fundamentals as well as advanced new technological research on biohydrogen production by focusing on recent global research with emphasis on the technological, environmental, socioeconomic, and techno-economic aspects, this volume will be a valuable resource for faculty and advanced students, chemical and biochemical engineers, bioprocess technologists, biochemists, environmental scientists and researchers as well as theoretical and applied statisticians and policymakers in this area.

The replacement of fossil-derived compounds by bio-based fuels and chemicals is crucial for the implementation of a sustainable bioeconomy. In this context, microorganisms are key players for biofuels' production from renewable sources. Biotechnological biofuel production processes require conversion microorganisms capable of both efficiently assimilating renewable low-cost carbon sources and diverting their metabolisms towards the specific biofuel. Exploring the wide diversity of microorganisms available on Earth will surely aid to make the production of green fuels a reality. This book gives a wide overview of different microbial-based processes for green fuels production. The book also includes techno-economic analysis and highlights strategic, commercial and environmental interests in promoting green fuels. All these facts make this book very valuable not only for the scientific community but also for biofuel companies and policy makers.

Microfluidic biochips have gained prominence due to their versatile applications to biochemistry and health-care domains such as point-of-care clinical diagnosis of tropical and cardiovascular diseases, cancer, diabetes, toxicity analysis, and for the mitigation of the global HIV crisis, among others. Microfluidic Lab-on-Chips (LoCs) offer a convenient platform for emulating various fluidic operations in an automated fashion. However, because of the inherent uncertainty of fluidic operations, the outcome of biochemical experiments performed on-chip can be erroneous even if the chip is tested a priori and deemed to be defect-free. This book focuses on the issues encountered in reliable sample preparation with digital microfluidic biochips (DMFBs), particularly in an error-prone environment. It presents state-of-the-art error management techniques and underlying algorithmic challenges along with their comparative discussions. Describes a comprehensive framework for designing a robust and error-tolerant biomedical system which will help in migrating from cumbersome medical laboratory tasks to small-sized LOC-based systems Presents a comparative study on current error-tolerant strategies for robust sample preparation using DMFBs and reports on efficient algorithms for error-tolerant sample dilution using these devices Illustrates how algorithmic engineering, cyber-physical tools, and software techniques are helpful in implementing fault tolerance Covers the challenges associated with design automation for biochemical sample preparation Teaches how to implement biochemical protocols using software-controlled microfluidic biochips Interdisciplinary in its coverage, this reference is written for practitioners and researchers in biochemical, biomedical, electrical, computer, and mechanical engineering, especially those involved in LOC or bio-MEMS design.

The book provides background knowledge on the molecular biology of plants and a comprehensive description of plant biotechnology. It is in three parts. Part A deals with an overview of Plant Molecular Biology. Part B is concerned with Plant Tissue Culture. Part C is about Plant Genetic Engineering and Biotechnological Applications. Several transgenic applications dealt with in detail are in areas of engineering plants for stress tolerance, metabolic engineering of plants, transplastomic technology, crop protection, and antisense technology in plants. One of the highlights of this book is that it presents the concepts of both plant molecular biology and plant biotechnology.