Biomass-Derived Materials for Environmental Applications presents state-of-the-art coverage of bio-based materials that can be applied to address the growing global concern of pollutant discharge in the environment. The book examines the production, characterization and application of bio-based materials for remediation. Organized clearly by type of material, the book includes details on lignocellulosic materials, natural clays, carbonaceous materials, composites and advanced materials from natural origins. Readers will find an interdisciplinary and practical examination of these materials and their use in environmental remediation that will be valuable to environmental scientists, materials scientists, environmental chemists, and environmental engineers alike.

Biomass, Biofuels, and Biochemicals: Algae-Based Biomaterials for Sustainable Development, Biomedical, Environmental Remediation and Sustainability Assessment, a new release in the Biomass, Biofuels, and Biochemicals series, covers algae-based biomaterials-the green and renewable material that can be produced from various micro- and macro-algae species and utilized for several applications, including biomedical healthcare and environmental remediation. The book provides assessments of the current development of algae-based biomaterials, delivering information on diverse feedstocks and technologies for biomaterial production with a perspective surrounding sustainable development. In addition, circular bioeconomy aspects are included, giving researchers a comprehensive, sustainable development view. This valuable addition to the series delivers a much-needed reference for today's applications in biomedical and environmental remediation.

Citrus Fruit: Biology, Technology and Evaluation, Second Edition presents a comprehensive view of these globally important crops, from cultivars to consumer acceptability. Now fully revised and updated to address the latest technologies and advancements, along with an exploration of highly current topics, including the impacts of climate and COVID-19, the book presents fresh fruit scenarios from around the globe. Sections explore the challenge of losses, background on fresh citrus cultivars production, factors that impact fruit quality, morphology, anatomy, physiology and biochemistry of fruit, fruit maturity, grades, and physico-chemical characteristics before moving into aspects of post-harvest technology. From irradiation and quality control to the nutritive, medicinal and safety aspects, the book presents the wide range of factors that can impact successful citrus crop production, delivery and consumption. Intended as a resource for researchers and scientists dealing with the growth, development and distribution of citrus fruit, the book provides up-to-date coverage on global citrus fruit production and practices.

Polymeric Biomaterials for Healthcare Applications details a broad range of polymeric biomaterials, methods of synthesis and preparation, and their various applications in healthcare and biomedicine. The book provides a fundamental overview of polymers and processing technologies to allow clinical scientists to explore the use of these polymers in alternative applications. A wide variety of healthcare applications are covered, including treatment for autoimmune diseases and bacterial infections, tissue engineering, gene delivery, wound dressing, and more. The book provides a core introductory text for clinical and materials scientists new to the area of polymeric biomaterials. This book will prove useful to academics and researchers in materials science, biomedical engineering, clinical science and pharmaceutical science.

Polymeric materials offer a high level of versatility due to the range of applications possible within the biomedical and clinical fields - including wound closure - particularly in comparison to metals or ceramics. These specialised materials also allow for a diverse array of therapeutic effects. Although there have been advances in improving polymeric materials for surgical sutures, there is little information available regarding improving the therapeutic value of sutures, and advanced technologies used to implement this improvement. Advanced Technologies and Polymer Materials for Surgical Sutures provides thorough coverage on suture materials with improved mechanical and therapeutic properties that can improve quality of life; chapter topics include drug-releasing kinetics of sutures, shape memory polymer sutures and future trends. This book is a useful resource for academics and researchers in the materials science and biomedical engineering fields, as well as professionals in biomaterials and biotextiles development and clinicians looking to learn more about suture material properties and suture/body interactions.

IN "THE ANTIDOTE," Barry Werth draws upon unprecedented inside reporting spanning more than two decades to provide a groundbreaking closeup of the upstart pharmaceutical company Vertex and the ferocious but indispensable world of Big Pharma that it inhabits.
In 1989, the charismatic Joshua Boger left Merck, then America's most admired business, to found a drug company that would challenge industry giants and transform health care. Werth described the company's tumultuous early days during the AIDS crisis in "The Billion-Dollar Molecule," a celebrated classic of science and business journalism. Now he returns to tell a riveting story of Vertex's bold endurance and eventual success.
The $325 billion-a-year pharmaceutical business is America's toughest and one of its most profitable. It's riskier and more rigorous at just about every stage than any other business, from the towering biological uncertainties inherent in its mission to treat disease; to the 30-to-1 failure rate in bringing out a successful medicine even after a molecule clears all the hurdles to get to human testing; to the multibillion-dollar cost of ramping up a successful product; to operating in the world's most regulated industry, matched only by nuclear power.
Werth captures the full scope of Vertex's twentyfive- year drive to deliver breakthrough medicines. At a time when America struggles to maintain its innovative edge, "The Antidote" is a powerful inside look at one of the most intriguing and important business stories of recent decades.

Advanced Materials for Sustainable Environmental Remediation: Terrestrial and Aquatic Environments presents detailed, comprehensive coverage of novel and advanced materials that can be applied to address the growing global concern of the pollution of natural resources in waters, the air and soil. It provides fundamental knowledge on available materials and treatment processes, as well as applications, including adsorptive remediation and catalytic remediation. Organized clearly by type of material, this book presents a consistent structure for each chapter, including characteristics of the materials, basic and important physicochemical features for environmental remediation applications, routes of synthesis, recent advances as remediation medias, and future perspectives. This book offers an interdisciplinary and practical examination of available materials and processes for environmental remediation that will be valuable to environmental scientists, materials scientists, environmental chemists, and environmental engineers alike.

Engineered Nanostructures for Therapeutics and Biomedical Applications offers a single reference for a diverse biomedical readership to learn about the application of nanotechnology in biomedicine and biomedical engineering, from past developments to current research and future prospects. This book sets out a broad selection of biomedical and therapeutic applications for nanostructures, including bioimaging, nanorobotics, orthopedics, and tissue engineering, offering a useful, multidisciplinary approach. Each chapter discusses challenges faced in each discipline, including limiting factors, biocompatibility, and toxicity, thus enabling the reader to make informed decisions in their research. This book is a comprehensive, broad overview of the role and significance of nanomaterials and their composites that also includes discussions of key aspects in the field of biomedicine. It will be of significant interest to academics and researchers in materials science and engineering, biomedicine and biomedical engineering, chemical engineering, pharmaceutics, bioimaging, and nanorobotics.

Digital Agritechnology: Robotics and Systems for Agriculture and Livestock Production describes how systems acquire and use data in livestock production and agricultural systems, and how researchers can extract and aggregate efficiencies. The origins of digital agritechnology are decades old, with robotic milkers available for over 20 years and GPS-based tractor controls existing for nearly 30. However, only a few capabilities of these sensing and control systems are used. This book addresses the need to educate agriculturists on the full usage scale of these arable and livestock systems.

Multi-Chaos, Fractal and Multi-Fractional Artificial Intelligence of Different Complex Systems addresses different uncertain processes inherent in the complex systems, attempting to provide global and robust optimized solutions distinctively through multifarious methods, technical analyses, modeling, optimization processes, numerical simulations, case studies as well as applications including theoretical aspects of complexity. Foregrounding Multi-chaos, Fractal and Multi-fractional in the era of Artificial Intelligence (AI), the edited book deals with multi- chaos, fractal, multifractional, fractional calculus, fractional operators, quantum, wavelet, entropy-based applications, artificial intelligence, mathematics-informed and data driven processes aside from the means of modelling, and simulations for the solution of multifaceted problems characterized by nonlinearity, non-regularity and self-similarity, frequently encountered in different complex systems. The fundamental interacting components underlying complexity, complexity thinking, processes and theory along with computational processes and technologies, with machine learning as the core component of AI demonstrate the enabling of complex data to augment some critical human skills. Appealing to an interdisciplinary network of scientists and researchers to disseminate the theory and application in medicine, neurology, mathematics, physics, biology, chemistry, information theory, engineering, computer science, social sciences and other far-reaching domains, the overarching aim is to empower out-of-the-box thinking through multifarious methods, directed towards paradoxical situations, uncertain processes, chaotic, transient and nonlinear dynamics of complex systems.

Biotechnology in Healthcare presents up-to-date knowledge on the emerging field of biotechnology as applied to the healthcare industry. Biotechnology has revolutionized healthcare in the last two decades by developing and introducing novel diagnostics, therapeutics, and preventive measures; whether it is noncommunicable or communicable disease, primary or secondary care, or public health, it has shown its immense potential to provide a solution to the healthcare providers, physicians, and allied health care professionals. The second volume, Applications and Initiatives, contains 19 chapters focused on the applications of biotechnology related to public healthcare, hospital management, oncology, neurodegenerative and infectious diseases, regenerative medicine, IVF, clinical trials, precision food, FMGCs, PPCPs, pharmaceuticals, and smart technologies to monitor pandemic. Further, this volume also presents government initiatives and entrepreneurship challenges in healthcare biotechnology sector. This is a valuable resource for students, biotechnologists, bioinformaticians, clinicians, and members of biomedical and healthcare fields who need to understand more about the promising developments of the emerging field of biotechnology in healthcare.

Application of Sampling and Detection Methods in Agricultural Plant Biotechnology describes detection methods for seed, plants and grain derived from biotechnology. This international handbook, based on a series of workshops carried out for governments in collaboration with ILSI and Co-published in partnership with the Cereals & Grains Association, provides the technical and practical information needed to develop, validate and use detection methods. This useful resource provides readers with the tools necessary to carry out reliable sampling, detection and interpretation of data.

Bioinformatics in Agriculture: Next Generation Sequencing Era is a comprehensive volume presenting an integrated research and development approach to the practical application of genomics to improve agricultural crops. Exploring both the theoretical and applied aspects of computational biology, and focusing on the innovation processes, the book highlights the increased productivity of a translational approach. Presented in four sections and including insights from experts from around the world, the book includes: Section I: Bioinformatics and Next Generation Sequencing Technologies; Section II: Omics Application; Section III: Data mining and Markers Discovery; Section IV: Artificial Intelligence and Agribots. Bioinformatics in Agriculture: Next Generation Sequencing Era explores deep sequencing, NGS, genomic, transcriptome analysis and multiplexing, highlighting practices forreducing time, cost, and effort for the analysis of gene as they are pooled, and sequenced. Readers will gain real-world information on computational biology, genomics, applied data mining, machine learning, and artificial intelligence. This book serves as a complete package for advanced undergraduate students, researchers, and scientists with an interest in bioinformatics.

Biomedical Product and Materials Evaluation: Standards and Ethics provides a much-needed overview of the procedures, issues, standards and ethical issues in the early development of biomedical products. The book covers a range of key biomedical products, from 3D printed organs and blood derived products, to stem calls and decellularized tissue products. Each chapter reviews a single product type, associated materials, biomedical applications, proven development strategies, and potential challenges. The core focus of the book is on the standardization and ethical aspects of biomedical product development, with these elements addressed and discussed in chapters dedicated to product evaluation. This is a useful reference for academics, researchers and industry professionals in R&D groups with an interest in biomaterial research and production, as well as those working in the fields of biomedical engineering, biotechnology and toxicology.

Microbiome Under Changing Climate: Implications and Solutions presents the latest biotechnological interventions for the judicious use of microbes to ensure optimal agricultural yield. Summarizing aspects of vulnerability, adaptation and amelioration of climate impact, this book provides an important resource for understanding microbes, plants and soil in pursuit of sustainable agriculture and improved food security. It emphasizes the interaction between climate and soil microbes and their potential role in promoting advanced sustainable agricultural solutions, focusing on current research designed to use beneficial microbes such as plant growth promoting microorganisms, fungi, endophytic microbes, and more. Changes in climatic conditions influence all factors of the agricultural ecosystem, including adversely impacting yield both in terms of quantity and nutritional quality. In order to develop resilience against climatic changes, it is increasingly important to understand the effect on the native micro-flora, including the distribution of methanogens and methanotrophs, nutrient content and microbial biomass, among others.

Advances in Applied Microbiology, Volume 118 continues the comprehensive reach of this widely read and authoritative review source in microbiology. Users will find invaluable references and information on a variety of areas relating to the topics of microbiology.

Green Sustainable Process for Chemical and Environmental Engineering and Science, the latest release in the Green Composites: Preparation, Properties and Allied Applications series, deals with the most promising aspects of green composites. The book presents in-depth and updated literature related to the manufacturing of green composites and their properties and discusses special features of green composites and their applications in daily life. All green composites covered in this work are polymeric and of bio-origin. The book also provides industrial applications of green composites. Topics covered include the use of green composites, vegetable packing, foam, blends, rubber, solar cells, adhesives and 3D printing.

Combination Drug Delivery Approach as an Effective Therapy for Various Diseases explores the use of bioengineering tools in combination drug delivery approaches to control various diseases at different clinical stages of synergistic action, varying mechanisms of action, and during the suppression of drug resistance. The book presents fundamental knowledge on the experiential and experimental aspects of drug combination approaches in order to equip rational applications in preventing the emergence of resistance during the treatment of various diseases. It provides a holistic understanding of the principles behind formation, characterization, applications, regulations, toxicity, challenges and future perspectives of combination drug delivery approaches. It will be of interest to researchers and advanced graduate students in pharmaceutical science, chemistry, biology and medicine, as well as pharmaceutical companies and scientific organizations.

Innovations in Fermentation and Phytopharmaceutical Technologies discusses recent advancements in the field of different bioprocessing aspects for the development of different reactors, fermented products and phytopharmaceuticals. Written by leading experts in the field, the book presents the basic principles of upstream processing techniques, advanced downstream process technologies, and recycling of by-products during formation/production of various fermented and phytopharmaceutical products. The informative chapters in the book outline an application-oriented path for academicians, researchers and scientists in the field of industrial fermentation technology and phytopharmaceutical production.

Immunomodulatory Effects of Nanomaterials: Assessment and Analysis provides an overview of the modulatory impact of nanomaterials on the immune system, as well as evaluative and analytical methods for assessing effects. Sections cover a range of common nanomaterials for biomedical use and how different properties can elicit varied responses from the immune system. The immunomodulatory effects of these materials are then discussed, with coverage on adverse and/or toxic effects on the immune system, as well as desired modulatory effects to improve efficacy of applied therapeutics. Readers will also learn about the best evaluation methods for immunomodulatory effects of nanomaterials and associated risks. This book is a useful reference for academics and researchers with an interest in immunology, but it is also idea for those working in the fields of materials science, biomedical engineering, pharmaceutical science, immunology and toxicology.

Biomaterials for Angiogenesis and Vasculogenesis covers the application of materials designed to encourage new blood vessel formation. Angiogenesis and vasculogenesis play an important role in tissue engineering and regenerative medicine research by promoting vascular networks inside engineered tissues and thereby increasing tissue healing and regeneration. However, researchers are faced with the challenge of finding suitable materials for improving angiogenesis and vascular formation in assays. This book reviews a broad range of biomaterials for the promotion of blood vessel genesis, from polymers and bioactive glass, to nanomaterial scaffolds and 3D angiogenic constructs. In addition, the book covers a variety of applications for biomaterials in tissue repair and regeneration, including cardiovascular regeneration, liver tissue engineering and much more. It will serve as a detailed reference for researchers in academia and industry, working in the fields of biomedical science and engineering, materials science, regenerative medicine and translational medicine.