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To succeed in the lab, it is crucial to be comfortable with the math calculations that are part of everyday work. This accessible introduction to common laboratory techniques focuses on the basics, helping even readers with good math skills to practice the most frequently encountered types of problems. Basic Laboratory Calculations for Biotechnology, Second Edition discusses very common laboratory problems, all applied to real situations. It explores multiple strategies for solving problems for a better understanding of the underlying math. Primarily organized around laboratory applications, the book begins with more general topics and moves into more specific biotechnology laboratory techniques at the end. This book features hundreds of practice problems, all with solutions and many with boxed, complete explanations; plus hundreds of "story problems" relating to real situations in the lab. Additional features include: Discusses common laboratory problems with all material applied to real situations Presents multiple strategies for solving problems help students to better understand the underlying math Provides hundreds of practice problems and their solutions Enables students to complete the material in a self-paced course structure with little teacher assistance Includes hundreds of "story problems"that relate to real situations encountered in the laboratory
This authoritative reference work presents comprehensive information about one of the most important and most wide-spread classes of (bio)organic compounds: the polysaccharides. The comprehensive and thoroughly up-to-date handbook presents the sources, identification, analysis, biosynthesis, biotechnology and applications of important polysaccharides likes starches, cellulose, chitin, gum and microbial polysaccharides. Polysaccharides can exhibit complex structure and various functional activities. These bio macromolecules can therefore serve as raw materials for various different materials, e.g. rayon, cellulose acetate, celluloid and nitrocellulose; and they find multiple applications, for instance as surgical threads (chitin), as sources of energy, dietary fibers, as blood flow adjuvants, in cosmetics, emulsion stabilizers, film formers, binders, viscosity increasing agents or skin conditioning agenta, as food additives in gums, chewing gum bases and as vaccines. Polysaccharides form the basis for useful products, like xanthan gum, dextran, welan gum, gellan gum, diutan gum and pullulan. Some of the polysaccharide-derived products have interesting and useful properties and show biological activities, such as immunomodulatory, antibacterial, anti-mutagenic, radioprotective, anti-oxidative, anti-ulcer, antidepressant, anti-septicaemic or anti-inflammatory activities. All these applications and properties of polysaccharides are for the first time compiled in a thorough and comprehensive overview in the present work. This reference work is organized thematically in four parts: Part I. Polysaccharides: Occurrence, Structure, Distribution and Biotechnology. Part II. Methods. Part III. Bioactive Polysaccharides. Part IV. Polysaccharides as Food. This reference work is edited by experienced experts, all chapters are written by well recognized international specialists. It is useful to all those working in the field of botany, phytochemistry, pharmacy, drug delivery, molecular biology, metabolomics, forestry, environment, conservation, biotechnology and NGOs working for forest protection.
The best source for cutting-edge insights into AI in healthcare operations AI in Healthcare: How Artificial Intelligence Is Changing IT Operations and Infrastructure Services collects, organizes and provides the latest, most up-to-date research on the emerging technology of artificial intelligence as it is applied to healthcare operations. Written by a world-leading technology executive specializing in healthcare IT, this book provides concrete examples and practical advice on how to deploy artificial intelligence solutions in your healthcare environment. AI in Healthcare reveals to readers how they can take advantage of connecting real-time event correlation and response automation to minimize IT disruptions in critical healthcare IT functions. This book provides in-depth coverage of all the most important and central topics in the healthcare applications of artificial intelligence, including: Healthcare IT AI Clinical Operations AI Operational Infrastructure Project Planning Metrics, Reporting, and Service Performance AIOps in Automation AIOps Cloud Operations Future of AI Written in an accessible and straightforward style, this book will be invaluable to IT managers, administrators, and engineers in healthcare settings, as well as anyone with an interest or stake in healthcare technology.
Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. Nanotechnology-based targeted delivery strategies could improve the delivery efficiency of IO agents as well as provide additional avenues for novel therapeutic and vaccination strategies. Additionally, a number of locally-administered immunogenic scaffolds and therapeutic strategies, such as the use of STING agonist, could benefit from rationally designed biomaterials and delivery approaches. Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side.
Biology and Engineering of Stem Cell Niches covers a wide spectrum of research and current knowledge on embryonic and adult stem cell niches, focusing on the understanding of stem cell niche molecules and signaling mechanisms, including cell-cell/cell-matrix interactions. The book comprehensively reviews factors regulating stem cell behavior and the corresponding approaches for understanding the subsequent effect of providing the proper matrix molecules, mechanical cues, and/or chemical cues. It encompasses a variety of tools and techniques for developing biomaterials-based methods to model synthetic stem cell niches in vivo, or to enhance and direct stem cell fate in vitro. A final section of the book discusses stem cell niche bioengineering strategies and current advances in each tissue type.
Multiple myeloma is a form of bone cancer. Specifically, it is a cancer of the plasma cells found in bone marrow (bone soft tissue). Normal plasma cells are an important part of the immune system. Mathematical models for multiple myeloma based on ordinary and partial differential equations (ODE/PDEs) are presented in this book, starting with a basic ODE model in Chapter 1, and concluding with a detailed ODE/PDE model in Chapter 4 that gives the spatiotemporal distribution of four dependent variable components in the bone marrow and peripheral blood: (1) protein produced by multiple myeloma cells, termed the M protein, (2) cytotoxic T lymphocytes (CTLs), (3) natural killer (NK) cells, and (4) regulatory T cells (Tregs). The computer-based implementation of the example models is presented through routines coded (programmed) in R, a quality, open-source scientific computing system that is readily available from the Internet. Formal mathematics is minimized, e.g., no theorems and proofs. Rather, the presentation is through detailed examples that the reader/researcher/analyst can execute on modest computers using the R routines that are available through a download. The PDE analysis is based on the method of lines (MOL), an established general algorithm for PDEs, implemented with finite differences.
Hybrid Nanomaterials for Drug Delivery covers a broad range of hybrid nanomaterials and nanocomposites used in drug delivery systems. The book reviews a variety of hybrid nanomaterials and structures, including polymer-lipid, chitosan-based, protein-inorganic, quantum dot hybrids, and more. The strengths, limitations and regulatory aspects of hybrid drug delivery systems are also discussed, allowing readers to make informed decisions when choosing to utilize hybrid nanomaterials. Users will find this to be an exciting and comprehensive look into this emerging area. It will be of particular interest to academics and researchers working in materials science, engineering, biomedical engineering, nanotechnology and pharmaceutical science. Multi nanocarrier-based hybrid systems are an emerging concept in the field of drug delivery that allow researchers to avoid some of the challenges faced when administering drugs, such as low bioavailability, development of drug resistance, toxicities, premature drug release, and therapeutic efficacy.
Biosensors are essential to an ever-expanding range of applications, including healthcare; drug design; detection of biological, chemical, and toxic agents; environmental monitoring; biotechnology; aviation; physics; oceanography; and the protection of civilian and engineering infrastructures. This book, like the previous five books on biosensors by this author (and one by the co-author), addresses the neglected areas of analyte-receptor binding and dissociation kinetics occurring on biosensor surfaces. Topics are covered in a comprehensive fashion, with homogeneous presentation for the benefit of the reader. The contributors address the economic aspects of biosensors and incorporate coverage of biosensor fabrication and nanobiosensors, among other topics. The comments, comparison, and discussion presented provides a better perspective of where the field of biosensors is heading.
Titanium Alloys for Biomedical Development and Applications: Design, Microstructure, Properties and Application systematically introduces basic theories and progress in the research of biomedical ss-Ti alloys achieved by researchers from different fields. It focuses on a high-strength and low elastic modulus biomedical ss-Ti alloy (TLM), etc. designed by the authors. The alloy design methods, microstructural characteristics, mechanical properties, surface treatment methods and biocompatibility of the TLM alloy are discussed in detail, along with a concise description of the medical devices made from this alloy and the application examples. This book will appeal to researchers as well as students from different disciplines, including materials science, biology, medicine and engineering fields.
Microbiome Under Changing Climate: Implications and Solutions presents the latest biotechnological interventions for the judicious use of microbes to ensure optimal agricultural yield. Summarizing aspects of vulnerability, adaptation and amelioration of climate impact, this book provides an important resource for understanding microbes, plants and soil in pursuit of sustainable agriculture and improved food security. It emphasizes the interaction between climate and soil microbes and their potential role in promoting advanced sustainable agricultural solutions, focusing on current research designed to use beneficial microbes such as plant growth promoting microorganisms, fungi, endophytic microbes, and more. Changes in climatic conditions influence all factors of the agricultural ecosystem, including adversely impacting yield both in terms of quantity and nutritional quality. In order to develop resilience against climatic changes, it is increasingly important to understand the effect on the native micro-flora, including the distribution of methanogens and methanotrophs, nutrient content and microbial biomass, among others.
Autonomous Robot-Aided Optical Manipulation for Biological Cells gives a systematically and almost self-contained description of the many facets of modeling, sensing, and control techniques or experimentally exploring emerging trends in optical manipulation of biological cell in micro/nanorobotics systems. To achieve biomedical applications, reliability design, modeling, and precision control are vitally important for the development of engineering systems. With the advances in modeling, sensing, and control techniques, it is opportunistic to exploit them for the benefit of reliability design, actuation, and precision control of micro/nanomanipulation systems to expanding the applications of robot at the micro and nano scales, especially in biomedical engineering. This book presents new techniques in reliability modeling and advanced control of robot-aided optical manipulation of biological cells systems. The book will be beneficial to the researchers within robotics, mechatronics, biomedical engineering, and automatic control society, including both academic and industrial parts.
This book provides an account of the biogenic synthesis of nanomaterials by using different microorganisms. The chapters are focused on the biosynthesis of various metal and metal oxide nanosized materials by using bacteria, actinomycetes, fungi, and algae, including mechanisms of microbial synthesis. Other chapters summarize recent developments of microbial-based nanostructures for the management of food-borne pathogens, plant pathogenic fungi, as nutrients, and biomedical applications. Microorganisms are discussed not only as biofactories for the synthesis of nanomaterials but also as removal agents of toxic metals from the environment. Exposure sources and ecotoxicity of microbially synthesized nanoparticles are also discussed.
Sustainable Biofuels: Opportunities and challenges, a volume in the "Applied Biotechnology Reviews" series, explores the state-of-the-art in research and applied technology for the conversion of all types of biofuels. Its chapters span a broad spectrum of knowledge, from fundamentals and technical aspects to optimization, combinations, economics, and environmental aspects. They cover various facets of research, production, and commercialization of bioethanol, biodiesel, biomethane, biohydrogen, biobutanol, and biojet fuel. This book discusses biochemical, thermochemical, and hydrothermal conversion of unconventional feedstocks, including the role of biotechnology applications to achieve efficiency and competitiveness. Through case studies, techno-economic analysis and sustainability assessment, including life cycle assessment, it goes beyond technical aspects to provides actual resources for better decision-making during the development of commercially viable technology by researchers, PhD students, and practitioners in the field of bioenergy. It is also a useful resource for those in adjacent areas, such as biotechnology, industrial microbiology, chemical engineering, environmental engineering, and sustainability science, who are working on solutions for the bioeconomy. The ability to compare different technologies and their outcome that this book provides is also beneficial for energy analysts, consultants, planners, and policy-makers. The "Applied Biotechnology Reviews" series highlights current development and research in biotechnology-related fields, combining in single-volume works the theoretical aspects and real-world applications for better decision-making.
Stimuli-Responsive Nanocarriers: Recent Advances in Tailor-Made Therapeutics compiles dispersed knowledge into a complete and comprehensive source to help researchers understand and progress stimuli-responsive nanocarriers. The book contains recent advancements made in the field of stimuli-responsive nanocarriers with their application in controlled drug delivery against various diseases. It focuses on the design, mechanism, construction, therapeutic application and future challenges of stimuli-responsive nanocarriers which will help new researchers in designing next generation tailor-made advanced therapeutics. Finally, the book covers future aspects and challenges present in the route of development of stimuli responsive nanocarriers for disease therapeutics. Various recent advances and biomedical applications assembled in this book will guide scientists on how to design and develop novel controlled drug release systems.
The book Nanopharmaceuticals in regenerative medicine is a collective and comprehensive volume of the latest innovations in nanoscience technology for practical use in clinical, biomedicine and diagnostic arena. The term nanotechnology pops up in every segment of modern-day life. The primary aim of this book is to deliver the precise information to students, educators, technologists and researchers. A conglomerate of scientists from various research fields contributed to the chapters, giving detailed descriptions on the most recent developments of nanotechnology in the area of disease management. This book will also be useful for industrial research and development partners, start-up entrepreneurs, government policy makers and other professionals who are interested in nanomedicines.
Evidence-Based Validation of Herbal Medicines brings together current thinking and practice in the areas of characterization and validation of natural products. This book reviews all aspects of evaluation and development of medicines from plant sources, including their cultivation, collection, phytochemical and phyto-pharmacological evaluation, and therapeutic potential. Emphasis is placed on describing the full range of evidence-based analytical and bio-analytical techniques used to characterize natural products, including -omic technologies, phyto-chemical analysis, hyphenated techniques, and many more.
Bone substitute biomaterials are fundamental to the biomedical sector, and have recently benefitted from extensive research and technological advances aimed at minimizing failure rates and reducing the need for further surgery. This book reviews these developments, with a particular focus on the desirable properties for bone substitute materials and their potential to encourage bone repair and regeneration.
Part I covers the principles of bone substitute biomaterials for
medical applications. One chapter reviews the quantification of
bone mechanics at the whole-bone, micro-scale, and non-scale
levels, while others discuss biomineralization, osteoductivization,
materials to fill bone defects, and bioresorbable materials. Part
II focuses on biomaterials as scaffolds and implants, including
multi-functional scaffolds, bioceramics, and titanium-based foams.
Finally, Part III reviews further materials with the potential to
encourage bone repair and regeneration, including cartilage grafts,
chitosan, inorganic polymer composites, and marine organisms.
Biomedical Product and Materials Evaluation: Standards and Ethics provides a much-needed overview of the procedures, issues, standards and ethical issues in the early development of biomedical products. The book covers a range of key biomedical products, from 3D printed organs and blood derived products, to stem calls and decellularized tissue products. Each chapter reviews a single product type, associated materials, biomedical applications, proven development strategies, and potential challenges. The core focus of the book is on the standardization and ethical aspects of biomedical product development, with these elements addressed and discussed in chapters dedicated to product evaluation. This is a useful reference for academics, researchers and industry professionals in R&D groups with an interest in biomaterial research and production, as well as those working in the fields of biomedical engineering, biotechnology and toxicology.
Nanomaterials in the Battle Against Pathogens and Disease Vectors presents an overview of the use of nanotechnology to mitigate pathogens of concern, and is the first book to discuss applications of nanotechnology in the fight against all three major domains of disease-causing pathogens. Bacteria, viruses, and parasites constitute the list of emerging and re-emerging pathogens of high priority. Nanotechnology has proven to be a groundbreaking success in the elimination, targeted toxicity, precise immunogenicity, diagnosis, and imaging of these major pathogens and disease vectors. This text discusses basic concepts and advanced applications for bacteria, viruses, and parasites. It describes the use of metallic and non-metallic nanoparticles and nanotoxicity, as well as presents future applications of nanotechnology in biological applications. This work is ideal for engineers and scientists across the interdisciplinary fields of materials science, biomedical engineering, biotechnology, and others concerned with mitigating the risk and effect of pathogens.
Plant Breeding and Cultivar Development features an optimal balance between classical and modern tools and techniques related to plant breeding. Written for a global audience and based on the extensive international experience of the authors, the book features pertinent examples from major and minor world crops. Advanced data analytics (machine learning), phenomics and artificial intelligence are explored in the book's 28 chapters that cover classical and modern plant breeding. By presenting these advancements in specific detail, private and public sector breeding programs will learn about new, effective and efficient implementation. The insights are clear enough that non-plant breeding majoring students will find it useful to learn about the subject, while advanced level students and researchers and practitioners will find practical examples that help them implement their work.
Handbook of Analytical Quality by Design addresses the steps involved in analytical method development and validation in an effort to avoid quality crises in later stages. The AQbD approach significantly enhances method performance and robustness which are crucial during inter-laboratory studies and also affect the analytical lifecycle of the developed method. Sections cover sample preparation problems and the usefulness of the QbD concept involving Quality Risk Management (QRM), Design of Experiments (DoE) and Multivariate (MVT) Statistical Approaches to solve by optimizing the developed method, along with validation for different techniques like HPLC, UPLC, UFLC, LC-MS and electrophoresis. This will be an ideal resource for graduate students and professionals working in the pharmaceutical industry, analytical chemistry, regulatory agencies, and those in related academic fields.
"Engineered Biomimicry" covers a broad range of research topics in the emerging discipline of biomimicry. Biologically inspired science and technology, using the principles of math and physics, has led to the development of products as ubiquitous as Velcro (modeled after the spiny hooks on plant seeds and fruits). Readers will learn to take ideas and concepts like this from nature, implement them in research, and understand and explain diverse phenomena and their related functions. From bioinspired computing and medical products to biomimetic applications like artificial muscles, MEMS, textiles and vision sensors, "Engineered Biomimicry" explores a wide range of technologies informed by living natural systems.
"Engineered Biomimicry" helps physicists, engineers and material
scientists seek solutions in nature to the most pressing technical
problems of our times, while providing a solid understanding of the
important role of biophysics. Some physical applications include
adhesion superhydrophobicity and self-cleaning, structural
coloration, photonic devices, biomaterials and composite materials,
sensor systems, robotics and locomotion, and ultra-lightweight
The fields of microfluidics and BioMEMS are significantly impacting cell biology research and applications through the application of engineering solutions to human disease and health problems. The dimensions of microfluidic channels are well suited to the physical scale of biological cells, and the many advantages of microfluidics make it an attractive platform for new techniques in biology.
This new professional reference applies the techniques of microsystems to cell culture applications. The authors provide a thoroughly practical guide to the principles of microfluidic device design and operation and their application to cell culture techniques. The resulting book is crammed with strategies and techniques that can be immediately deployed in the lab. Equally, the insights into cell culture applications will provide those involved in traditional microfluidics and BioMEMS with an understanding of the specific demands and opportunities presented by biological applications.
The goal is to guide new and interested researchers and
technology developers to the important areas and
state-of-the-practice strategies that will enhance the efficiency
and value of their technologies, devices and biomedical
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