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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical)

A Short History Of Humanity - How Migration Made Us Who We Are (Paperback): Johannes Krause, Thomas Trappe A Short History Of Humanity - How Migration Made Us Who We Are (Paperback)
Johannes Krause, Thomas Trappe; Translated by Caroline Waight
R350 R280 Discovery Miles 2 800 Save R70 (20%) Ships in 5 - 10 working days

Humanity has often found itself on the precipice. We've survived and thrived because we've never stopped moving...

In this eye-opening book, Johannes Krause, Chair of the Max Planck Institute for the History of Humanity, offers a new way of understanding our past, present and future.

Marshalling unique insights from archaeogenetics, an emerging new discipline that allows us to read our ancestors' DNA like journals chronicling personal stories of migration, Krause charts two millennia of adaption, movement and survival, culminating in the triumph of Homo Sapiens as we swept through Europe and beyond in successive waves of migration - developing everything from language, the patriarchy, disease, art and a love of pets as we did so.

We also meet our ancestors, from those many of us have heard of - such as Homo Erectus and the Neanderthals - to the wildly unfamiliar but no less real: the recently discovered Denisovans, who ranged across Asia and, like humans, interbred with Neanderthals; the Aurignacians, skilled artists who, 40,000 years ago, brought about an extraordinary transformation in what our species could invent and create; the Varna, who buried their loved ones with gold long before the Pharaohs of Egypt did; and the Gravettians, big game hunters who were Europe's most successful early settlers until they perished in the face of the toughest opponent humanity had ever faced: the ice age.

As well as being a radical new telling of our shared story, this book is a reminder that the global problems that keep us awake at night - climate catastrophe; the sudden emergence of deadly epidemics; refugee crises; ethnic conflict; over-population - are all things we've faced, and overcome, before.

Molecular Biology - Structure and Dynamics of Genomes and Proteomes (Hardcover, 2nd edition): Jordanka Zlatanova Molecular Biology - Structure and Dynamics of Genomes and Proteomes (Hardcover, 2nd edition)
Jordanka Zlatanova
R5,011 Discovery Miles 50 110 Ships in 12 - 17 working days

Molecular Biology: Structure and Dynamics of Genomes and Proteomes 2nd edition illustrates the essential principles behind the transmission and expression of genetic information at the level of DNA, RNA, and proteins. Emphasis is on the experimental basis of discovery and the most recent advances in the field while presenting a rigorous, yet still concise, summary of the structural mechanisms of molecular biology. Topics new to this edition include the CRISPR-Cas gene editing system, Coronaviruses - structure, genome, vaccine and drug development, and newly-recognised mechanisms for transcription termination. The text is written for advanced undergraduate or graduate-level courses in molecular biology. Key Features * Highlights the experimental basis of important discoveries in molecular biology * Thoroughly updated with new information on gene editing tools, viruses, and transcription mechanisms, termination and antisense. * Provides learning objectives for each chapter. * Includes a list of relevant videos from the internet about the topics covered in the chapter.

Microbial Systematics - Biomolecules and Natural Macromolecules Applications (Hardcover): Bhagwan Narayan Rekadwad Microbial Systematics - Biomolecules and Natural Macromolecules Applications (Hardcover)
Bhagwan Narayan Rekadwad
R4,357 Discovery Miles 43 570 Ships in 12 - 17 working days

Microbial species isolated from extreme and pristine habitats are always diverse, which indicates biomolecules secreted by these species might have importance. A cure for disease is a desire considering the catastrophic situations that threaten the lives of humans and animals. Currently, the world is facing the health, social and economic, and diplomatic impacts of infectious communicable diseases caused by bacteria and viruses. It is a necessity to understand the huge microbial diversity residing everywhere with us in this world. Microorganisms are species that were born at the start of “life” and will stay after the end of all other forms of life in this world. This unseen majority has significant effects on the biogeochemical cycle as well as has numerous medical and non-medical applications. So, the ability of microorganisms to produce bioactive compounds and how they can be used in different fields, especially medicine and health care, have been discussed in this book.

The Masterpiece of Nature - The Evolution and Genetics of Sexuality (Paperback): Graham Bell The Masterpiece of Nature - The Evolution and Genetics of Sexuality (Paperback)
Graham Bell
R1,472 Discovery Miles 14 720 Ships in 12 - 17 working days

Originally published in 1982, The Masterpiece of Nature examines sex as representative of the most important challenge to the modern theory of evolution. The book suggests that sex evolved, not as the result of normal Darwinian processes of natural selection, but through competition between populations or species - a hypothesis elsewhere almost universally discredited. The book also discusses the nature of sex and its consequences for the individual and for the population, as well as various other theories of sex. Since the value of these theories is held to reside wholly in their ability to predict the patterns of sexuality observed in nature, the book seeks to provide an extensive review of the circumstances in which sexuality is attenuated or lost throughout the animal kingdom, and these facts are then used to weigh up the merits of the rival theories. This book will be of interest to researchers in the area of genetics, ecology and evolutionary biology.

Advances in DNA Sequence-Specific Agents, Volume 2 (Hardcover, UK ed.): J.B. Chaires Advances in DNA Sequence-Specific Agents, Volume 2 (Hardcover, UK ed.)
J.B. Chaires
R1,890 Discovery Miles 18 900 Ships in 12 - 17 working days

DNA sequence specificity is a sub-specialty in the general area of molecular recognition. This area includes macromolecular-molecular interactions (e.g., protein-DNA), oligomer-DNA interacitons (e.g., triple strands), and ligand-DNA interactions (e.g., drug-DNA). It is this latter group of DNA sequence specificity interactions that is the subject of Volumes 1 and 2 of "Advances in DNA Sequence Specific Agents." As was the case for Volume 1, Part A also covers methodology, but in Volume 2 we include calorimetric titrations, molecular modeling, X-ray crystallographic and NMR structural studies, and transcriptional assays. Part B also follows the same format as Volume 1 and describes the sequence specificities and covalent and noncovalent interactions of small ligands with DNA.
This volume is aimed in general at scientists who have an interest in deciphering the molecular mechanisms for sequence recognition of DNA. The methods have general applicability to small molecules as well as oligomers and proteins, while the examples provide general principles involved in sequence recognition.

Reconfiguring Nature (2004) - Issues and Debates in the New Genetics (Paperback): Peter Glasner Reconfiguring Nature (2004) - Issues and Debates in the New Genetics (Paperback)
Peter Glasner
R1,049 Discovery Miles 10 490 Ships in 12 - 17 working days

Published in 2004, this collection will encourage and foster informed discussion of key issues as society comes to grips with the implications of genetic engineering, the mapping and sequencing of the human genome, and the advent of the post-genomic era. The contributors are prominent social scientists, health specialists, journalists, bioethicists and commercial representatives from the UK, Finland, Germany, Holland and Norway who are at the leading edge of current research. the book will therefore appeal to the interested public, health and other professionals, teachers and students. This book was originally published as part of the Cardiff Papers in Qualitative Research series edited by Paul Atkinson, Sara Delamont and Amanda Coffey. The series publishes original sociological research that reflects the tradition of qualitative and ethnographic inquiry developed at Cardiff. The series includes monographs reporting on empirical research, edited collections focussing on particular themes, and texts discussing methodological developments and issues.

The Semantic Theory of Evolution (Paperback): Marcello Barbieri The Semantic Theory of Evolution (Paperback)
Marcello Barbieri
R969 Discovery Miles 9 690 Ships in 12 - 17 working days

Originally published in 1985, The Semantic Theory of Evolution addresses the notion that life is not shaped by the single law of natural selection, but instead by a plurality of laws that resemble grammatical rules in language. This remarkable work presents a semantic theory centering on the concept of the ribotype. Supported by both sound facts and logical arguments, this analysis reaches beyond the established cadre of biological thought to unravel many of life's mysteries and paradoxes, including the origin of the cell and the nucleus and the evolution of ribosomes.

Human Evolution - An Introduction for the Behavioural Sciences (Paperback): Graham Richards Human Evolution - An Introduction for the Behavioural Sciences (Paperback)
Graham Richards
R1,087 Discovery Miles 10 870 Ships in 12 - 17 working days

Originally published in 1987, Human Evolution looks at theories of the evolution of human behaviour (contemporary at the time of publication). The book reviews competing theories of psychological and social evolution and provides a detailed historical introduction to the subject. A key theoretical concern which emerges in the book includes the psychological significance of the human evolution issue itself. The period of human evolution covered ranges from the demise of the Miocene hominoids, to the emergence of 'civilization'. Topics covered include: functions of 'origin myths', history of the study of human evolution, methods and data-bases, theories of the nature of 'hominisation', origins of bipedalism, language and tool-use, theories of social evolution, theories of cave art and the spread of Homo sapiens to America and Australia.

Functional Affinities of Man, Monkeys, and Apes - A Study of the Bearings of Physiology and Behaviour on the Taxonomy and... Functional Affinities of Man, Monkeys, and Apes - A Study of the Bearings of Physiology and Behaviour on the Taxonomy and Phylogeny of Lemurs, Monkeys, Apes, and Man (Paperback)
S. Zuckerman
R976 Discovery Miles 9 760 Ships in 12 - 17 working days

Originally published in 1933 Functional Affinities of Man, Monkeys and Apes gives a taxonomic and phylogenetic survey and the findings of diverse experimental investigations of lemurs, monkeys, and apes. The book discusses the inter-relationships of different Primates and emphasizes seldom-used approaches to the question of primate phylogeny. The book attempts to show how little they have been systematically tried, and argues for a regard to the proper place of functional investigations in the study of the classification and evolution of Primates. This book will be of interest to anthropologists, scientists and historians alike.

Routledge International Handbook of Social Neuroendocrinology (Paperback): Oliver C. Schultheiss, Pranjal H. Mehta Routledge International Handbook of Social Neuroendocrinology (Paperback)
Oliver C. Schultheiss, Pranjal H. Mehta
R1,423 Discovery Miles 14 230 Ships in 12 - 17 working days

The Routledge International Handbook of Social Neuroendocrinology is an authoritative reference work providing a balanced overview of current scholarship spanning the full breadth of the rapidly developing field of social neuroendocrinology. Considering the relationships between hormones, the brain, and social behavior, this collection brings together groundbreaking research in the field for the first time. Featuring 39 chapters written by leading researchers, the handbook offers impressive breadth of coverage. It begins with an overview of the history of social neuroendocrinology before discussing its methodological foundations and challenges. Other topics covered include state-of-the-art research on dominance and aggression; social affiliation; reproduction and pair bonding (e.g., sexual behavior, sexual orientation, romantic relationships); pregnancy and parenting; stress and emotion; cognition and decision making; social development; and mental and physical health. The handbook adopts a lifespan approach to the study of social neuroendocrinology throughout, covering the role that hormones play during gestation, childhood, adolescence, and adulthood. It also illustrates the evolutionary forces that have shaped hormone-behavior associations across species, including research on humans, non-human primates, birds, and rodents. The handbook will serve as an authoritative reference work for researchers, students, and others intrigued by this topic, while also inspiring new lines of research on interactions among hormones, brain, and behavior in social contexts.

A Probabilistic Model of the Genotype/Phenotype Relationship: Does Life Play the Dice? - Does Life Play the Dice? (Paperback):... A Probabilistic Model of the Genotype/Phenotype Relationship: Does Life Play the Dice? - Does Life Play the Dice? (Paperback)
Jean-Pierre Hugot
R1,407 Discovery Miles 14 070 Ships in 12 - 17 working days

A Probabilistic Model of the Genotype/Phenotype Relationship provides a new hypothesis on the relationship between genotype and phenotype. The main idea of the book is that this relationship is probabilistic, in other words, the genotype does not fully explain the phenotype. This idea is developed and discussed using the current knowledge on complex genetic diseases, phenotypic plasticity, canalization and others.

Forensic DNA Analysis - Technological Development and Innovative Applications (Hardcover): Elena Pilli, Andrea Berti Forensic DNA Analysis - Technological Development and Innovative Applications (Hardcover)
Elena Pilli, Andrea Berti
R4,471 Discovery Miles 44 710 Ships in 12 - 17 working days

Forensic DNA Analysis: Technological Development and Innovative Applications provides a fascinating overview of new and innovative technologies and current applications in forensic genetics. Edited by two forensic experts with many years of forensic crime experience with the Italian police and with prestigious academic universities, the volume takes an interdisciplinary perspective, the volume presents an introduction to genome polymorphisms, discusses, forensic genetic markers, presents a variety of new methods and techniques in forensic genetics, and looks at a selection of new technological innovations and inventions now available from commercial vendors. The book is an important resource for scientists, researchers, and other experts in the field who will find it of interest for its exhaustive discussion of the most important technological innovations in forensic genetics. For those newer to the field, the volume will be an invaluable reference guide to the forensic world.

Eukaryotic Gene Regulation - Volume II (Paperback): Gerald M Kolodny Eukaryotic Gene Regulation - Volume II (Paperback)
Gerald M Kolodny
R1,414 Discovery Miles 14 140 Ships in 12 - 17 working days

The cause of cancer and its many manifestations is at present unknown. Since many of its manifestations, including is control of cell division, appear to represent abnormal patterns of gene expression, studies of the regulation of gene expression nwill provide important insights in the understanding and treatment of cancer. This volume attempts to present some of the recent work on regulation of gene expression in eukaryotic cells.

Placenta - The Tree of Life (Paperback): Ornella Parolini Placenta - The Tree of Life (Paperback)
Ornella Parolini
R1,425 Discovery Miles 14 250 Ships in 12 - 17 working days

Long regarded as biological waste, the placenta is gaining momentum as a viable product for clinical use. Due to their unique properties, placental cells and derivatives show great promise in curing various diseases. Utilizing contributions from world-renowned experts, Placenta: The Tree of Life considers the therapeutic potential of these cells. It examines new stem cell-based strategies and highlights recent studies that advance the range of treatment for a number of illnesses. Emphasizing the potential research and therapeutic use of stem cells, the book discusses the development, structure, and functions of the human placenta. It introduces overall aspects of the immune system, explains some of the immune mechanisms during pregnancy, and shows the role of the placenta in these mechanisms. Current scientific research is presented that focuses on the mechanisms of action underlying the therapeutic benefit of cells isolated from different placental regions. An exhaustive examination, this pivotal work: Considers how perinatal cells may represent an important source for cell therapy approaches in the near future, in both human and veterinary medicine Describes the clinical potential of placenta-derived cells in regenerative medicine-specifically in neurological disorders, metabolic liver diseases, inflammatory diseases, and autoimmune diseases Explains how cells isolated from different placental tissues share basic properties Placenta: The Tree of Life summarizes the advantages of perinatal tissue as a source of cells with therapeutic potential and is designed for use in the study of genetics, stem cell science, placental function, reproductive biology, regenerative medicine, and related fields.

Cyclic Nucleotide Signaling (Paperback): Xiaodong Cheng Cyclic Nucleotide Signaling (Paperback)
Xiaodong Cheng
R1,421 Discovery Miles 14 210 Ships in 12 - 17 working days

Showcasing the recent progresses of the field, Cyclic Nucleotide Signaling covers the major tools and methodologies used in various areas of research. The majority of the chapters are protocol oriented, with the goal of providing clear directions for laboratory use. Students and investigators new to the field will find this book particularly informative, as will scientists already actively researching nucleotide signaling.

The Ethical Animal (Paperback): C.H. Waddington The Ethical Animal (Paperback)
C.H. Waddington
R1,120 Discovery Miles 11 200 Ships in 12 - 17 working days

First published in 1960, this book discusses the ethical implications of the view of man's nature and his place in the biological world. C. H. Waddington highlights issues of the time, such as social upheavals related to social mobility, and the changing nature of philosophical thinking in relation to the nature of good. The author argues that man differs from all other animals in his ability for social teaching and learning and that this provides him with a second method of evolutionary advance, in addition to biology. He advances this through the idea that man has the capacity to entertain ethical ideas, which is an essential and necessary feature of this new mode of evolution. From here he draws the conclusion that a consideration of the broad trends of evolution provides a framework within which we can rationally discuss the relative merits of the various systems of ethical belief current in the world. In presenting his argument, Waddington draws on research in biology, psychology, the social sciences, and philosophy. He concludes with a short consideration of some of the most important ethical problems facing mankind at the time of the book's publication.

Science and Ethics - An Essay (Paperback): C.H. Waddington Science and Ethics - An Essay (Paperback)
C.H. Waddington
R1,108 Discovery Miles 11 080 Ships in 12 - 17 working days

First published in 1942 (second impression 1944), this book forms a debate about the endeavour to find an intellectual basis for ethics in science.

The Nature of Life (Paperback): C.H. Waddington The Nature of Life (Paperback)
C.H. Waddington
R1,105 Discovery Miles 11 050 Ships in 12 - 17 working days

First published in 1961, this book explains the main trends and problems in modern biological thought, at that time. It was based on lectures presented at the University College of the West Indies, Jamaica, in 1960 to members from different faculties and is therefore an accessible guide for all to the subject.

Forensic DNA Analysis - Current Practices and Emerging Technologies (Paperback): Jaiprakash G. Shewale, Ray H Liu Forensic DNA Analysis - Current Practices and Emerging Technologies (Paperback)
Jaiprakash G. Shewale, Ray H Liu
R2,408 Discovery Miles 24 080 Ships in 12 - 17 working days

The field of forensic DNA analysis has grown immensely in the past two decades and genotyping of biological samples is now routinely performed in human identification (HID) laboratories. Application areas include paternity testing, forensic casework, family lineage studies, identification of human remains, and DNA databasing. Forensic DNA Analysis: Current Practices and Emerging Technologies explores the fundamental principles and the application of technologies for each aspect of forensic DNA analysis. The book begins by discussing the value of DNA evidence and how to properly recognize, document, collect, and store it. The remaining chapters examine: The most widely adopted methods and the best practices for DNA isolation from forensic biological samples and human remains Studies carried out on the use of both messenger RNA and small (micro) RNA profiling Real-time polymerase chain reaction (PCR) methods for quantification and assessment of human DNA prior to genotyping Capillary electrophoresis (CE) as a tool for forensic DNA analysis Next-generation short tandem repeat (STR) genotyping kits for forensic applications, the biological nature of STR loci, and Y-chromosome STRs (Y-STRs) Mitochondrial DNA (mtDNA) sequence analysis Single nucleotide polymorphisms (SNPs) and insertion/deletion polymorphisms (indels) in typing highly degraded DNA Deep-sequencing technologies The current state of integrated systems in forensic DNA analysis The book concludes by discussing various aspects of sample-processing training and the entities that provide such training programs. This volume is an essential resource for students, researchers, teaching faculties, and other professionals interested in human identification/forensic DNA analysis.

Epigenetics, Environment, and Genes (Paperback): Sun Woo Kang Epigenetics, Environment, and Genes (Paperback)
Sun Woo Kang
R2,542 Discovery Miles 25 420 Ships in 12 - 17 working days

This title includes a number of Open Access chapters. Epigenetics is the study of DNA and chromatin modifications that play an important role in the regulation of various genomic functions. This important book reviews human and cellular data that underline paradoxical findings with respect to the contribution of heredity and environment to phenotype, followed by a reinterpretation of these experiments that incorporate epigenetic factors.

Epigenetics and Pathology - Exploring Connections Between Genetic Mechanisms and Disease Expression (Paperback): Kasirajan... Epigenetics and Pathology - Exploring Connections Between Genetic Mechanisms and Disease Expression (Paperback)
Kasirajan Ayyanathan
R2,555 Discovery Miles 25 550 Ships in 12 - 17 working days

This title includes a number of Open Access chapters. This important book explores recent research by experts in the field pertaining to the role played by genetic factors in human pathology. A range of perspectives creates a well-rounded picture, including: host-pathogen interactions causal relationships between genes and the environment the effects of environmental chemicals on gene expression DNA methylation The book also covers the analysis and provides models for understanding the epigenetics-pathology connection. This book is designed for use by senior undergraduate and graduate students from several disciplines such as general, molecular, cellular biology, genetics, genomics, proteomics, and bioinformatics. It will also serve as a reference book for existing researchers and new investigators entering this rather unexplored field.

Specific Gene Expression and Epigenetics - The Interplay Between the Genome and Its Environment (Paperback): Kasirajan... Specific Gene Expression and Epigenetics - The Interplay Between the Genome and Its Environment (Paperback)
Kasirajan Ayyanathan
R2,542 Discovery Miles 25 420 Ships in 12 - 17 working days

This title includes a number of Open Access chapters. This new volume on gene expression and epigenetics discusses environmental effects related to specific gene expression. The book also shows methods for bioinformatic analysis of the epigenome. The book is broken into two sections: the first looks at eukaryotic DNA methylation and the second addresses how to integrate genomic medicine into clinical practice. The book includes chapters on these topics: * Gene expression in colon cancer tissue * Epigenetics in human acute kidney injury * Embryologically relevant candidate genes in MRKH patients * DNA methylation in common skeletal disorders * Causal relationships in genomics * Predicting severe asthma exacerbations in children * Epigenetic understanding of gene-environment interactions in psychiatric disorders

Omics in Clinical Practice - Genomics, Pharmacogenomics, Proteomics, and Transcriptomics in Clinical Research (Paperback): Yu... Omics in Clinical Practice - Genomics, Pharmacogenomics, Proteomics, and Transcriptomics in Clinical Research (Paperback)
Yu Liu
R2,561 Discovery Miles 25 610 Ships in 12 - 17 working days

This title includes a number of Open Access chapters. This book serves as an introduction to genomics, proteomics, and transcriptomics, putting these fields in relation to human disease and ailments. The various chapters consider the role of translation and personalized medicine, as well as pathogen detection, evolution, and infection, in relation to genomics, proteomics, and transcriptomics. The topic of companion diagnostics is also covered. The book is broken into five sections. Part I examines the connection between omics and human disease. Part II looks at the applications for the fields of translational and personalized medicine. Part III focuses on molecular and genetic markers. Part IV describes the use of omics while studying pathogens, and Part V examines the applications for companion diagnostics. The book: * Introduces genomics, proteomics, and transcriptomics in relation to human disease and ailments * Considers the role of translation and personalized medicine in relation to genomics, proteomics, and transcriptomics * Covers molecular and genetic markers * Considers the role of genomics, proteomics, and transcriptomics in relation to pathogen detection, evolution, and infection * Covers companion diagnostics in relation to genomics, proteomics, and transcriptomics clinical applications and research

Genomics and Proteomics - Principles, Technologies, and Applications (Paperback): Devarajan Thangadurai, Jeyabalan Sangeetha Genomics and Proteomics - Principles, Technologies, and Applications (Paperback)
Devarajan Thangadurai, Jeyabalan Sangeetha
R2,557 Discovery Miles 25 570 Ships in 12 - 17 working days

The book provides scope and knowledge on advanced techniques and its applications into the modern fields of biotechnology-genomics and proteomics. In this book, different genomics and proteomics technologies and principles are examined. The fundamental knowledge presented in this book opens up an entirely new way of approaching DNA chip technology, DNA array assembly, gene expression analysis, assessing changes in genomic DNA, structure-based functional genomics, protein networks, and so on. Topics in the book include: * Different gene products with a similar role in neuronal defense against oxidative * Gene-gene and gene-environment interactions in genetic epidemiology * Elucidation of proto-oncogene c-abl function with the use of mouse models and the disease model of chronic myeloid leukemia * Next-generation sequencing, microbiome evaluation, molecular microbiology, and their impact on human health * Proteomics and prostate cancer * RNA interference therapeutics * Molecular mechanisms of hepatitis C virus entry * Molecular phylogenetics for elucidation of evolutionary processes from biological data * The impact of transgenic crops on soil quality, microbial diversity, and plant-associated communities. * Biotechnological and genomic approaches for abiotic stress tolerance in crop plants The book will be valuable for biotechnology researchers and bioinformatics professionals and students in all fields of biotechnology and will serve to broaden their knowledge about these newer tools, techniques, innovations, and applications.

The Future of Man - The BBC Reith Lectures 1959 (Paperback): P.B. Medawar The Future of Man - The BBC Reith Lectures 1959 (Paperback)
P.B. Medawar
R1,205 Discovery Miles 12 050 Ships in 10 - 15 working days

Originally published in 1960, The Future of Man is a chronicle of Professor Medwar's Reith lectures of 1959. The book outlines his predictions about the future estate of man, with the 'process of foretelling, rather than with what is actually foretold'. He asks, can we predict the future size of populations? What is the evidence and theoretical background for the belief that human intelligence is declining? Could human beings become uniformly excellent or is inborn diversity and inequality a necessary part of the texture of human populations? The lectures tried to answer these questions and attempts to end with a definition of the biological standing of man. This book will be of interest to anthropologists, biologists and natural historians.

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