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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical)

Genetics as Social Practice - Transdisciplinary Views on Science and Culture (Paperback): Barbara Prainsack, Silke Schicktanz,... Genetics as Social Practice - Transdisciplinary Views on Science and Culture (Paperback)
Barbara Prainsack, Silke Schicktanz, Gabriele Werner-felmayer
R1,357 Discovery Miles 13 570 Ships in 12 - 17 working days

Recent debate about the ethical and regulatory dimensions of developments in genetics has sidelined societal and cultural aspects, which arguably are indispensable for a nuanced understanding of the complexities of the topic. Regulatory and ethical debates benefit from taking seriously this 'third dimension' of culture, which often determines the configurations and limits of the space within which scientific, ethical and legal debate can take place. To fill this gap, this volume brings together contributions exploring the mutual relationships between genetics, markets, societies and identities in genetics and genomics. It draws upon the recent transdisciplinary debate on how socio-cultural factors influence understandings of 'genetics2.0' and shows how individual and collective identities are challenged or reinforced by cultural meanings and practices of genetics. This book will become a standard reference for everyone seeking to make sense of the controversies and shifts in the field of genetics in the second decade of the twenty-first century.

Heredity and Politics (Paperback): J.B.S. Haldane Heredity and Politics (Paperback)
J.B.S. Haldane
R523 Discovery Miles 5 230 Ships in 12 - 17 working days

This book, first published in 1938, is based on the Muirhead Lectures given at Birmingham University in February and March of 1937. The first half of this book is mainly devoted to an exposition of the principles of genetics, whilst the second half deals with more controversial topics, with the text providing an insight into the ideology of the time. This title will be of interest to students of politics and history.

Evolution - The Origins and Mechanisms of Diversity (Hardcover): Jonathan Bard Evolution - The Origins and Mechanisms of Diversity (Hardcover)
Jonathan Bard
R5,292 Discovery Miles 52 920 Ships in 12 - 17 working days

Evolution is the single unifying principle of biology and core to everything in the life sciences. More than a century of work by scientists from across the biological spectrum has produced a detailed history of life across the phyla and explained the mechanisms by which new species form. This textbook covers both this history and the mechanisms of speciation; it also aims to provide students with the background needed to read the research literature on evolution. Students will therefore learn about cladistics, molecular phylogenies, the molecular-genetical basis of evolutionary change including the important role of protein networks, symbionts and holobionts, together with the core principles of developmental biology. The book also includes introductory appendices that provide background knowledge on, for example, the diversity of life today, fossils, the geology of Earth and the history of evolutionary thought. Key Features Summarizes the origins of life and the evolution of the eukaryotic cell and of Urbilateria, the last common ancestor of invertebrates and vertebrates. Reviews the history of life across the phyla based on the fossil record and computational phylogenetics. Explains evo-devo and the generation of anatomical novelties. Illustrates the roles of small populations, genetic drift, mutation and selection in speciation. Documents human evolution using the fossil record and evidence of dispersal across the world leading to the emergence of modern humans.

Loose Leaf for Genetics: Analysis and Principles (Loose-leaf, 7th ed.): Robert Brooker Loose Leaf for Genetics: Analysis and Principles (Loose-leaf, 7th ed.)
Robert Brooker
R5,360 Discovery Miles 53 600 Ships in 10 - 15 working days
Experience and Development - A Festschrift in Honor of Sandra Wood Scarr (Paperback): Kathleen McCartney, Richard A. Weinberg Experience and Development - A Festschrift in Honor of Sandra Wood Scarr (Paperback)
Kathleen McCartney, Richard A. Weinberg
R1,483 Discovery Miles 14 830 Ships in 12 - 17 working days

The scope of these chapters reflects the strong influence that Sandra Wood Scarr's scholarship-her empirical research and theoretical contributions-has had on what we know about experience and development via the lens of the psychological sciences, especially the fields of developmental psychology, behavior genetics, early education and child care.

Modeling the 3D Conformation of Genomes (Paperback): Guido Tiana, Luca Giorgetti Modeling the 3D Conformation of Genomes (Paperback)
Guido Tiana, Luca Giorgetti
R1,553 Discovery Miles 15 530 Ships in 12 - 17 working days

This book provides a timely summary of physical modeling approaches applied to biological datasets that describe conformational properties of chromosomes in the cell nucleus. Chapters explain how to convert raw experimental data into 3D conformations, and how to use models to better understand biophysical mechanisms that control chromosome conformation. The coverage ranges from introductory chapters to modeling aspects related to polymer physics, and data-driven models for genomic domains, the entire human genome, epigenome folding, chromosome structure and dynamics, and predicting 3D genome structure.

Cilia - Development and Disease (Paperback): Paraskevi Goggolidou Cilia - Development and Disease (Paperback)
Paraskevi Goggolidou
R1,417 Discovery Miles 14 170 Ships in 12 - 17 working days

The scope of the book is to highlight the diverse roles of cilia in human development and disease. Almost all cell types form cilia and although they were first detected about 200 years ago, their significance was unclear. In the past ten years, it has become obvious that cilia have got sensory functions, as well as roles in motility and their mis-formation or the deregulation of the signaling pathways they control has been associated with defective development and human disease. Although research has concentrated on the role of the cilium in each organ, no effort has been made so far to bring all this information together and relate it to the various human diseases. This book aims to gather all the expertise that has been acquired on primary cilia and translate it into a medical and research context that will be of interest to postgraduate students, researchers, medics and scientists.

Aging is a Group-Selected Adaptation - Theory, Evidence, and Medical Implications (Paperback): Joshua Mitteldorf Aging is a Group-Selected Adaptation - Theory, Evidence, and Medical Implications (Paperback)
Joshua Mitteldorf
R1,415 Discovery Miles 14 150 Ships in 12 - 17 working days

Although books exist on the evolution of aging, this is the first book written from the perspective of again as an adaptive program. It offers an insight into the implications of research on aging genetics, The author proposes the Demographic Theory of Senescence, whereby aging has been affirmatively selected because it levels the death rate over time helping stabilize population dynamics and prevent extinctions.

A Mathematical Primer of Molecular Phylogenetics (Paperback): Xuhua Xia A Mathematical Primer of Molecular Phylogenetics (Paperback)
Xuhua Xia
R2,541 Discovery Miles 25 410 Ships in 12 - 17 working days

This volume, A Mathematical Primer of Molecular Phylogenetics, offers a unique perspective on a number of phylogenetic issues that have not been covered in detail in previous publications. The volume provides sufficient mathematical background for young mathematicians and computational scientists, as well as mathematically inclined biology students, to make a smooth entry into the expanding field of molecular phylogenetics. The book will also provide sufficient details for researchers in phylogenetics to understand the workings of existing software packages used. The volume offers comprehensive but detailed numerical illustrations to render difficult mathematical and computational concepts in molecular phylogenetics accessible to a variety of readers with different academic background. The text includes examples of solved problems after each chapter, which will be particularly helpful for fourth-year undergraduates, postgraduates, and postdoctoral students in biology, mathematics and computer sciences. Researchers in molecular biology and evolution will find it very informative as well.

Genetic Engineering - Recent Developments in Applications (Paperback): Dana M. Santos Genetic Engineering - Recent Developments in Applications (Paperback)
Dana M. Santos
R2,543 Discovery Miles 25 430 Ships in 12 - 17 working days

This title includes a number of Open Access chapters. A common tool in both research and agriculture, genetic engineering involves the direct manipulation of genes. Today's areas of medical research include genetic engineering to produce vaccines against disease, pharmaceutical development, and the treatment of disease. In agriculture, genetic engineering is used to modify crops and domestic animals to increase their yields, aid in production, and enhance nutritive aspects. This important book covers new research and studies in genetic engineering in the areas of medicine and agriculture.

Current Research in Embryology (Paperback): Sabine Globig Current Research in Embryology (Paperback)
Sabine Globig
R2,541 Discovery Miles 25 410 Ships in 12 - 17 working days

This title includes a number of Open Access chapters. Embryology is the study of embryos. It is the branch of biological science that deals with the formation and early development of an individual organism, from fertilization of the egg (ovum) to birth. This collection includes articles on some of the most important topics in embryology today, such as cryopreservation of human embryos, in vitro generation of neurons from embryonic stem cells, embryonic transfer, transcriptional profiling, and more.

The Role of Intellectual Property Rights in Agriculture and Allied Sciences (Paperback): Chandan Roy The Role of Intellectual Property Rights in Agriculture and Allied Sciences (Paperback)
Chandan Roy
R2,549 Discovery Miles 25 490 Ships in 12 - 17 working days

This important volume provides a basic understanding of the different forms of intellectual property rights in agricultural science. It provides an abundance of information on the use of IP laws in agriculture and allied subjects and their proper implementation in real-life practice. The chapter authors discuss different kinds of IP laws and their current status in developed as well as developing countries throughout the world. The protection of biological resources is crucial for food security for future generations. Biological resources are the source of several important genes. Researchers are interested in the development of plant varieties that can increase crop production, withstand dramatic climatic changes, etc. Protecting intellectual property rights in plant varieties and the rights of farmers and others are discussed in this volume. It also looks at new trends and developments in the field involving new IP strategies and the application of IP laws in agriculture and biotechnology and in the management of plant genetic resources.

Ethical Issues in Governing Biobanks - Global Perspectives (Paperback): Bernice Elger Ethical Issues in Governing Biobanks - Global Perspectives (Paperback)
Bernice Elger; Nikola Biller-Andorno, Alexander M. Capron
R1,536 Discovery Miles 15 360 Ships in 12 - 17 working days

Population genomics research drawing on genetic databases has expanded rapidly, with some of this information being combined in 'biobanks'. Managing this information in an appropriate way is a highly complex ethical issue in the health policy arena. This book combines theoretical and empirical research to analyze the areas of conflict and consensus in the regulatory and ethical frameworks that have been developed to govern biobanks. Ethicists from the Department of Ethics, Trade, Human Rights and Health Law (ETH) of the World Health Organization, the Institute of Biomedical Ethics of Geneva University and the Institute of Biomedical Ethics of the University of Zurich, with the support of the Geneva International Academic Network (GIAN), examine the conditions under which genetic databases can be established, kept, and made use of in an ethically acceptable way. In addition to a comprehensive review of the scientific literature and a comparative analysis of existing normative frameworks, they present the results of in-depth interviews with experts around the world concerning the most unresolved and controversial issues. The results of that study, combined with their normative analysis, leads to recommendations for a better international framework.

Genetic Association Studies - Background, Conduct, Analysis, Interpretation (Paperback): Mehmet Tevfik Dorak Genetic Association Studies - Background, Conduct, Analysis, Interpretation (Paperback)
Mehmet Tevfik Dorak
R2,528 Discovery Miles 25 280 Ships in 12 - 17 working days

Genetic Association Studies is designed for students of public health, epidemiology, and the health sciences, covering the main principles of molecular genetics, population genetics, medical genetics, epidemiology and statistics. It presents a balanced view of genetic associations with coverage of candidate gene studies as well as genome-wide association studies. All aspects of a genetic association study are included, from the lab to analysis and interpretation of results, but also bioinformatics approaches to causality assessment. The role of the environment in genetic disease is also highlighted. Genetic Association Studies will enable readers to understand and critique genetic association studies and set them on the way to designing, executing, analyzing, interpreting, and reporting their own.

Epigenetics in Organ Specific Disorders, Volume 34 (Paperback): Chandra S. Boosani, Ritobrata Goswami Epigenetics in Organ Specific Disorders, Volume 34 (Paperback)
Chandra S. Boosani, Ritobrata Goswami
R3,596 Discovery Miles 35 960 Ships in 12 - 17 working days

Epigenetics in Organ Specific Disorders, a new volume in the Translational Epigenetics series, provides a foundational overview and nuanced analysis of epigenetic gene regulation distinct to each organ type and organ specific disorders, fully elucidating the epigenetics pathways that promote and regulate disease. After a brief introduction, chapter authors compare epigenetic regulations across normal and disease conditions in different organ tissues, exploring similarities and contrasts. The role of epigenetic mechanisms in stem cells, cell-matrix interactions and cell proliferation, cell migration, cellular apoptosis, necrosis, pyknosis, tumor suppression, and immune responses across different organ types are examined in-depth. Organ specific epigenetic mechanisms and biomarkers of early use in developing drugs, which can selectively target the organ of interest, are also explored to enable new precision therapies.

Topological Data Analysis for Genomics and Evolution - Topology in Biology (Hardcover): Raul Rabadan, Andrew J. Blumberg Topological Data Analysis for Genomics and Evolution - Topology in Biology (Hardcover)
Raul Rabadan, Andrew J. Blumberg
R1,422 R1,343 Discovery Miles 13 430 Save R79 (6%) Ships in 12 - 17 working days

Biology has entered the age of Big Data. A technical revolution has transformed the field, and extracting meaningful information from large biological data sets is now a central methodological challenge. Algebraic topology is a well-established branch of pure mathematics that studies qualitative descriptors of the shape of geometric objects. It aims to reduce comparisons of shape to a comparison of algebraic invariants, such as numbers, which are typically easier to work with. Topological data analysis is a rapidly developing subfield that leverages the tools of algebraic topology to provide robust multiscale analysis of data sets. This book introduces the central ideas and techniques of topological data analysis and its specific applications to biology, including the evolution of viruses, bacteria and humans, genomics of cancer, and single cell characterization of developmental processes. Bridging two disciplines, the book is for researchers and graduate students in genomics and evolutionary biology as well as mathematicians interested in applied topology.

Transgenic Ascidians (Hardcover, 1st ed. 2018): Yasunori Sasakura Transgenic Ascidians (Hardcover, 1st ed. 2018)
Yasunori Sasakura
R4,421 Discovery Miles 44 210 Ships in 10 - 15 working days

This book comprehensively describes the transgenesis techniques and applied experimental methods in ascidians including enthusiastically developed original devices in addition to concrete examples of developmental biology studies. Ascidians have been one of the most important model animals in developmental biology for studying molecular and cellular processes underlying formation of the chordate body plan. Transgenic techniques such as microinjection, electropolation, cis-element analysis and application, and TALENs and CRISPR/Cas9 have been developed in ascidians for more than 20 years, and now many applied methods, some of which are unique in ascidians, have been accumulated. Those extensive technological innovations, such as cell isolation, cell labeling, germ-line transformation, marker transgenic lines, and the experimental systems for studying notochord formation and nervous system, are exceptional particularly in marine invertebrates. This book is useful for ascidian researchers to quickly access the techniques in which they are interested as well as to compare each technology to become familiar with specialized tips, and for biologists of other organisms to learn the unique techniques and ingenious attempts specific to ascidians. Providing detailed and easily understandable descriptions of techniques, the book will inspire ascidian specialists to improve their techniques, encourage anyone wanting to begin studying ascidians, and enable readers to immediately apply the techniques to the organisms they research.

Genome Editing Tools and Gene Drives - A Brief Overview (Hardcover): Reagan Mudziwapasi, Ringisai Chekera, Clophas Zibusiso... Genome Editing Tools and Gene Drives - A Brief Overview (Hardcover)
Reagan Mudziwapasi, Ringisai Chekera, Clophas Zibusiso Ncube, Irvonnie Shoko, Berlinda Ncube, …
R3,306 Discovery Miles 33 060 Ships in 12 - 17 working days

Genome-editing methods are becoming routine tools for molecular and cell biologists. Such tools include ZFNs, CRISPR, megaTALs and TALENs. These tools are revolutionizing the creation of precisely manipulated genomes to modify the characteristics of organisms or cells. Additionally, gene drives have altered the way we understand inheritance laws. They give us the ability to have total control of the inheritance of traits of choice and importance. This succinct volume summarizes the history, principles and applications - as well as the advantages and disadvantages - of each of these tools and various kinds of gene drives. The book is part of a program to produce books helpful to students and faculties of science at colleges and universities. This volume in the Pocket Guides to Biomedical Sciences series will help demystify these technologies. The book fills the gap between established conventional methods and the novel and exciting newly introduced tools of genome editing and gene drives. It will help young scientists understand the emerging genome-editing tools and gene drives, thereby promoting related research and adoption. Key Features Extensively reviews the current genome-editing tools and gene drives Clarifies the targeting mechanisms and specificity of genome-editing tools Details many different types of natural and synthetic gene drives Highlights concerns with gene drives and genome-editing tools Related Titles Brown, T. A. Genomes 4 (ISBN 978-0-8153-4508-4) Samuelsson, T. The Human Genome in Health and Disease: A Story in Four Letters (ISBN 978-0-8153-4591-6) Soh, J., et al. Genome Annotation (ISBN 978-1-4398-4117-4)

Applying Pharmacogenomics in Therapeutics (Hardcover): Xiaodong Feng, Hong-Guang  Xie Applying Pharmacogenomics in Therapeutics (Hardcover)
Xiaodong Feng, Hong-Guang Xie
R5,091 Discovery Miles 50 910 Ships in 12 - 17 working days

Recent advances in high-throughput gene sequencing and other omics biotechnologies have served as a springboard for the field of pharmacogenomics. Pharmacogenomics is now generally accepted as the major determinant of variable drug safety, efficacy, and cost-effectiveness. Therefore, widespread use of pharmacogenomics for patient care has become a critical requirement. There is an unprecedented urgency for aspiring and practicing clinicians to become trained on how to interpret data from pharmacogenomic testing in preparation for the future of healthcare-i.e., personalized medicine. Applying Pharmacogenomics in Therapeutics provides timely coverage of the principles, practice, and potential of pharmacogenomics and personalized medicine. Comprised of chapters contributed by well-established pharmacologists and scientists from US and Chinese academia and industry, this authoritative text: Demonstrates how to apply the principles of pharmacogenomics and its biotechnologies in patient care Depicts the use of genetic biomarkers in drug discovery and development, laboratory medicine, and clinical services Describes the practice of pharmacogenomics in the treatment of cancers, cardiovascular diseases, neurologic and psychiatric disorders, and pulmonary diseases Discusses the merging of pharmacogenomics and alternative medicine, as well as the integration of pharmacogenomics into pharmacoeconomics Each chapter begins with the key concepts, followed by in-depth explorations of case reports or critical evaluations of genetic variants/biomarkers, and concludes with questions for self-examination.

Young Adult Fiction by African American Writers, 1968-1993 - A Critical and Annotated Guide (Paperback): Deborah Kutenplon Young Adult Fiction by African American Writers, 1968-1993 - A Critical and Annotated Guide (Paperback)
Deborah Kutenplon; Ellen Olmstead
R1,474 Discovery Miles 14 740 Ships in 12 - 17 working days

First Published in 1996. Routledge is an imprint of Taylor & Francis, an informa company.

Telomeres, Diet and Human Disease - Advances and Therapeutic Opportunities (Paperback): Amelia Marti, Guillermo Zalba Telomeres, Diet and Human Disease - Advances and Therapeutic Opportunities (Paperback)
Amelia Marti, Guillermo Zalba
R1,407 Discovery Miles 14 070 Ships in 12 - 17 working days

The maintenance of telomeres-repetitive sequences at the end of chromosome-is essential to health. Dysfunction in telomere maintenance pathways plays a role in aging, cancer, atherosclerosis and other diseases. This has led to telomere maintenance as a prime target for patient therapies. This book describes the advances in telomere research as it applies to human health and especially how lifestyle and dietary factors could modify the telomerase maintenance process. The book examines the mechanisms involved, the primary of which are oxidative stress and the role of sirtuins, and how they can be modified by dietary patterns such as Mediterranean diet.

Genetics and the Psychology of Motor Performance (Paperback): Sigal Ben-Zaken, Gershon Tenenbaum, Veronique Richard Genetics and the Psychology of Motor Performance (Paperback)
Sigal Ben-Zaken, Gershon Tenenbaum, Veronique Richard
R1,264 Discovery Miles 12 640 Ships in 12 - 17 working days

Despite the prevalence of behavioral research conducted through genetic studies, there is an absence of literature pertaining to the genetics of motor behavior. Genetics and the Psychology of Motor Performance is the first book to integrate cutting-edge genetic research into the study of the psychological aspects of motor learning and control. The book's central line of enquiry revolves around the extent to which psychological factors central to motor proficiency - including personality, emotion, self-regulation, motivation, and perceptual-cognitive skills - are acquired or inherited. It explains how these factors affect motor performance, distilling the latest research into their genetic underpinnings and, in doing so, assessing the magnitude of the role genetics plays in the stages of motor development, from early proficiency through to expertise. Written by leading experts in the genetics of human performance and exercise psychology, and thoroughly illustrated throughout, Genetics and the Psychology of Motor Performance is a crucial resource for any upper-level student or researcher seeking a deeper understanding of motor learning. It is an important book for anyone studying or working in exercise psychology, motor development, exercise genetics, or exercise physiology more broadly.

Genetic Resources as Natural Information - Implications for the Convention on Biological Diversity and Nagoya Protocol... Genetic Resources as Natural Information - Implications for the Convention on Biological Diversity and Nagoya Protocol (Hardcover)
Manuel Ruiz Muller; Foreword by Joseph Henry Vogel
R4,348 Discovery Miles 43 480 Ships in 12 - 17 working days

Demonstrating the shortcomings of current policy and legal approaches to access and benefit-sharing (ABS) in the Convention on Biological Diversity (CBD), this book recognizes that genetic resources are widely distributed across countries and that bilateral contracts undermine fairness and equity. The book offers a practical and feasible regulatory alternative to ensure the goal of fairness and equity is effectively and efficiently met. Through a legal analysis that also incorporates historic, economic and sociological perspectives, the book argues that genetic resources are not tangible resources but information. It shows that the existing preference for bilateralism and contracts reflects resistance on the part of many of the stakeholders involved in the CBD process to recognize them as such. ABS issues respond very well to the economics of information, yet as the author explains, these have been either sidelined or overlooked. At a time when the Nagoya Protocol on ABS has renewed interest in feasible policy options, the author provides a constructive and provocative critique. The institutional, policy and regulatory framework constitute "bounded openness" under which fairness and equity emerge.

Heredity and Politics (Hardcover): J.B.S. Haldane Heredity and Politics (Hardcover)
J.B.S. Haldane
R1,260 Discovery Miles 12 600 Ships in 12 - 17 working days

This book, first published in 1938, is based on the Muirhead Lectures given at Birmingham University in February and March of 1937. The first half of this book is mainly devoted to an exposition of the principles of genetics, whilst the second half deals with more controversial topics, with the text providing an insight into the ideology of the time. This title will be of interest to students of politics and history.

Natural Products Interactions on Genomes (Hardcover): Siva Somasundaram Natural Products Interactions on Genomes (Hardcover)
Siva Somasundaram
R4,214 Discovery Miles 42 140 Ships in 12 - 17 working days

Foods from natural products are a major contributor to contemporary dietary needs. The knowledge of interactions of specific natural products on genes is accumulating due to recent scientific advancements. Natural Products Interactions on Genomes focuses on recent developments in understanding human genome interactions with various natural products. The book first examines selected major natural products and their interactions with selected genes for each chromosome in mammals, then moves on to focused discussions on interactions of natural products with genes that are involved in specific diseases. It includes studies on breast cancer and prostate cancer. The focus then shifts to the effects of natural products on microbial growth and a final chapter that discusses future challenges and prospects in the field. This book also presents a unique real-time approach by providing hyperlinks to websites with updated literature on natural products and interactions with genes involved in metabolic pathways. With a broad range of relevance among disciplines including biology, biomedical science, pharmacy, medicinal chemistry, and naturopathic and herbal medicine, Natural Products Interactions on Genomes provides a valuable reference. It gives you an understanding of the methods of study of natural products and their effects on genomes while pointing toward the future of natural products and the areas they impact in health and science.

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