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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical)

Pollination in Plants (Hardcover): Phatlane William Mokwala Pollination in Plants (Hardcover)
Phatlane William Mokwala
R3,315 Discovery Miles 33 150 Ships in 10 - 15 working days
Oncogenes as Transcriptional Regulators, v. 1 - Retrovial Oncogenes (Hardcover, illustrated edition): Moshe Vaniv, Jacques... Oncogenes as Transcriptional Regulators, v. 1 - Retrovial Oncogenes (Hardcover, illustrated edition)
Moshe Vaniv, Jacques Ghysdael
R2,583 Discovery Miles 25 830 Ships in 12 - 19 working days

The study of the molecular events leading to cellular transformation and cancer has progressed significantly in the last decade, and it has become apparent that many genes subject to modification in cancer are, in fact, transcription factors that govern the execution of the genetic programme of the cell. Transcription factors can behave either as oncogenes or as tumour suppressor genes. To date only a limited number of transcription factors have been associated with cancer. This volume deals with several transcription factor families that were first identified in oncogenic retroviruses. Each chapter contains a description of the structure of the transcription factors, the nature of target genes, the regulation of their activities, and an explaination of how they can deregulate cell growth and differentiation. This text should be suitable for the specialist scientist and the advanced student

Approaches in Bioremediation - The New Era of Environmental Microbiology and Nanobiotechnology (Hardcover, 1st ed. 2018):... Approaches in Bioremediation - The New Era of Environmental Microbiology and Nanobiotechnology (Hardcover, 1st ed. 2018)
Ramprasad, Elisabet Aranda
R5,152 Discovery Miles 51 520 Ships in 10 - 15 working days

Bioremediation refers to the clean-up of pollution in soil, groundwater, surface water, and air using typically microbiological processes. It uses naturally occurring bacteria and fungi or plants to degrade, transform or detoxify hazardous substances to human health or the environment. For bioremediation to be effective, microorganisms must enzymatically attack the pollutants and convert them to harmless products. As bioremediation can be effective only where environmental conditions permit microbial growth and action, its application often involves the management of ecological factors to allow microbial growth and degradation to continue at a faster rate. Like other technologies, bioremediation has its limitations. Some contaminants, such as chlorinated organic or high aromatic hydrocarbons, are resistant to microbial attack. They are degraded either gradually or not at all, hence, it is not easy to envisage the rates of clean-up for bioremediation implementation. Bioremediation represents a field of great expansion due to the important development of new technologies. Among them, several decades on metagenomics expansion has led to the detection of autochthonous microbiota that plays a key role during transformation. Transcriptomic guides us to know the expression of key genes and proteomics allow the characterization of proteins that conduct specific reactions. In this book we show specific technologies applied in bioremediation of main interest for research in the field, with special attention on fungi, which have been poorly studied microorganisms. Finally, new approaches in the field, such as CRISPR-CAS9, are also discussed. Lastly, it introduces management strategies, such as bioremediation application for managing affected environment and bioremediation approaches. Examples of successful bioremediation applications are illustrated in radionuclide entrapment and retardation, soil stabilization and remediation of polycyclic aromatic hydrocarbons, phenols, plastics or fluorinated compounds. Other emerging bioremediation methods include electro bioremediation, microbe-availed phytoremediation, genetic recombinant technologies in enhancing plants in accumulation of inorganic metals, and metalloids as well as degradation of organic pollutants, protein-metabolic engineering to increase bioremediation efficiency, including nanotechnology applications are also discussed.

DNA Pioneers and Their Legacy (Hardcover, New): Ulf Lagerkvist DNA Pioneers and Their Legacy (Hardcover, New)
Ulf Lagerkvist
R1,653 Discovery Miles 16 530 Ships in 12 - 19 working days

In this entertaining account of the origins of modern molecular biology, the lives of pioneering scientists in the field of nucleic acid research, and the discovery of DNA, Ulf Lagerkvist speaks not only to scientists but to all students and general readers with an interest in science. The author, whose career in the nucleic acid field began in the late 1940s, recreates historical episodes from the nineteenth and early twentieth centuries and introduces for a modern audience the scientists whose discoveries revolutionized the field of biology. Knowledge of these pioneers as professionals and as human beings, Lagerkvist believes, may help us see modern problems in a new light and appreciate the greatness of the researchers who contributed to the foundations of molecular biology and biochemistry. Among these scientific pioneers was nineteenth-century biochemist Friedrich Miescher, discoverer of nuclein, the material now known as DNA. The book also explores early research into general problems of the chemistry of biological materials. Lagerkvist vividly describes the research of such influential scientists as Albrecht Kossel, another early leading figure; Emil Fischer, who received the Nobel Prize in 1902 for his work on carbohydrates and purines and was regarded as the foremost chemist of his time; P. A. Levene, known for his discoveries concerning the structure of nucleotides and the way these nucleic acid building blocks are linked to one another; and Oswald T. Avery, often considered the grandfather of molecular genetics.

Human Population Genomics - Introduction to Essential Concepts and Applications (Hardcover, 1st ed. 2021): Kirk E. Lohmueller,... Human Population Genomics - Introduction to Essential Concepts and Applications (Hardcover, 1st ed. 2021)
Kirk E. Lohmueller, Rasmus Nielsen
R2,180 Discovery Miles 21 800 Ships in 12 - 19 working days

This textbook provides a concise introduction and useful overview of the field of human population genomics, making the highly technical and contemporary aspects more accessible to students and researchers from various fields. Over the past decade, there has been a deluge of genetic variation data from the entire genome of individuals from many populations. These data have allowed an unprecedented look at human history and how natural selection has impacted humans during this journey. Simultaneously, there have been increased efforts to determine how genetic variation affects complex traits in humans. Due to technological and methodological advances, progress has been made at determining the architecture of complex traits. Split in three parts, the book starts with the basics, followed by more advanced and current research. The first part provides an introduction to essential concepts in population genetics, which are relevant for any organism. The second part covers the genetics of complex traits in humans. The third part focuses on applying these techniques and concepts to genetic variation data to learn about demographic history and natural selection in humans. This new textbook aims to serve as a gateway to modern human population genetics research for those new to the field. It provides an indispensable resource for students, researchers and practitioners from disparate areas of expertise.

The Initiation of DNA Replication in Eukaryotes (Hardcover, 1st ed. 2016): Daniel L. Kaplan The Initiation of DNA Replication in Eukaryotes (Hardcover, 1st ed. 2016)
Daniel L. Kaplan
R5,937 R5,302 Discovery Miles 53 020 Save R635 (11%) Ships in 12 - 19 working days

Every time a cell divides, a copy of its genomic DNA has to be faithfully copied to generate new genomic DNA for the daughter cells. The process of DNA replication needs to be precisely regulated to ensure that replication of the genome is complete and accurate, but that re-replication does not occur. Errors in DNA replication can lead to genome instability and cancer. The process of replication initiation is of paramount importance, because once the cell is committed to replicate DNA, it must finish this process. A great deal of progress has been made in understanding how DNA replication is initiated in eukaryotic cells in the past ten years, but this is the first one-source book on these findings. The Initiation of DNA Replication in Eukaryotes will focus on how DNA replication is initiated in eukaryotic cells. While the concept of replication initiation is simple, its elaborate regulation and integration with other cell processes results in a high level of complexity. This book will cover how the position of replication initiation is chosen, how replication initiation is integrated with the phases of the cell cycle, and how it is regulated in the case of damage to DNA. It is the cellular protein machinery that enables replication initiation to be activated and regulated. We now have an in-depth understanding of how cellular proteins work together to start DNA replication, and this new resource will reveal a mechanistic description of DNA replication initiation as well.

Protein Structural Biology in Biomedical Research, Part A, Volume 22 (Hardcover): C Woodward Protein Structural Biology in Biomedical Research, Part A, Volume 22 (Hardcover)
C Woodward; Edited by N. M. Allewell
R3,142 Discovery Miles 31 420 Ships in 12 - 19 working days

Recent advances in protein structural biology, coupled with new developments in human genetics, have opened the door to understanding the molecular basis of many metabolic, physiological, and developmental processes in human biology. Medical pathologies, and their chemical therapies, are increasingly being described at the molecular level. For single-gene diseases, and some multi-gene conditions, identification of highly correlated genes immediately leads to identification of covalent structures of the actual chemical agents of the disease, namely the protein gene products. Once the primary sequence of a protein is ascertained, structural biologists work to determine its three-dimensional, biologically active structure, or to predict its probable fold and/or function by comparison to the data base of known protein structures. Similarly, three-dimensional structures of proteins produced by microbiological pathogens are the subject of intense study, for example, the proteins necessary for maturation of the human HIV virus. Once the three-dimensional structure of a protein is known or predicted, its function, as well as potential binding sites for drugs that inhibit its function, become tractable questions. The medical ramifications of the burgeoning results of protein structural biology, from gene replacement therapy to "rational" drug design, are well recognized by researchers in biomedical areas, and by a significant proportion of the general population. The purpose of this book is to introduce biomedical scientists to important areas of protein structural biology, and to provide an insightful orientation to the primary literature that shapes the field in each subject.
The chapters in this volume cover aspects of protein structural biology which have led to the recognition of fundamental relationships between protein structure and function.

Non-coding RNAs at the Cross-Road of Cardiometabolic Diseases and Cancer (Hardcover, 1st ed. 2021): Paul Holvoet Non-coding RNAs at the Cross-Road of Cardiometabolic Diseases and Cancer (Hardcover, 1st ed. 2021)
Paul Holvoet; Illustrated by Pieterjan Ginckels
R4,134 Discovery Miles 41 340 Ships in 10 - 15 working days

This book gives insight into the functional role of non-coding RNAs in central pathways contributing to the development of obesity, type 2 diabetes, non-alcoholic fatty liver disease, atherosclerosis, myocardial infarction, cardiomyopathy, and heart failure. It also sheds light on the relationship of this cluster with cancer. Tumor cells, in contrast to cells in cardiometabolic tissues, can regulate this cluster of non-coding RNAs to escape from oxidative stress and anti-tumor immunity and maintain insulin sensitivity, facilitating cancer progression. The book presents a cluster of non-coding RNAs that may be prospectively analyzed in extensive cohort studies to determine their value in risk-predicting machine learning algorithms. In addition, it emphasizes the role of microvesicles in communication between tumor-adjacent tissue, inflammatory cells, and tumor cells, with a special focus on the role of miR-155. The book intends to promote interdisciplinary research. Due to the comprehensive background information provided in each chapter, it is suitable for researchers in academia and industry and for graduate students in biology, bioengineering, and medicine.

Recent Advances in Tomato Breeding and Production (Hardcover): Seloame Tatu Nyaku, Agyemang Danquah Recent Advances in Tomato Breeding and Production (Hardcover)
Seloame Tatu Nyaku, Agyemang Danquah
R3,313 Discovery Miles 33 130 Ships in 10 - 15 working days
DeeNA (Hardcover): A. R. Sutton DeeNA (Hardcover)
A. R. Sutton
R896 Discovery Miles 8 960 Ships in 10 - 15 working days
Communicating Genetics - Visualizations and Representations (Hardcover, 1st ed. 2017): Han Yu Communicating Genetics - Visualizations and Representations (Hardcover, 1st ed. 2017)
Han Yu
R3,533 Discovery Miles 35 330 Ships in 12 - 19 working days

This book examines the visual representations used in the popular communication of genetics. Drawing upon public science communication theories, information design theories, and social semiotics, the book offers both in-depth analyses and high-level synthesis of how genetics is visualized for the U.S. public from the early 20th century to the present. Individual chapters focus on six visual genres: photographs, micrographs, illustrations, genetic code images, quantitative graphs, and molecular structure images. Han Yu challenges readers to consider the significance of these images we often take for granted, including their historical contexts, scientific backstories, information richness, stylistic choices, economic motivations, and social implications. In doing so, the book reveals the complex cognitive, affective, and social-cultural factors that both shape and are shaped by these images. The book will be particularly useful to scholars of public science communication and visual communication, practitioners of science communication, and scientists from a range of related life science disciplines.

Epigenetic Regulation of Skin Development and Regeneration (Hardcover, 1st ed. 2018): Vladimir A. Botchkarev, Sarah E. Millar Epigenetic Regulation of Skin Development and Regeneration (Hardcover, 1st ed. 2018)
Vladimir A. Botchkarev, Sarah E. Millar
R4,392 Discovery Miles 43 920 Ships in 10 - 15 working days

This indispensable volume highlights recent studies identifying epigenetic mechanisms as essential regulators of skin development, stem cell activity and regeneration. Chapters are contributed by leading experts and promote the skin as an accessible model system for studying mechanisms that control organ development and regeneration. The timely discussions contained throughout are of broad relevance to other areas of biology and medicine and can help inform the development of novel therapeutics for skin disorders as well as new approaches to skin regeneration that target the epigenome. Part of the highly successful Stem Cells and Regenerative Medicine series, Epigenetic Regulation of Skin Development and Regeneration uncovers the fundamental significance of epigenetic mechanisms in skin development and regeneration, and emphasizes the development of new therapies for a number of skin disorders, such as pathological conditions of epidermal differentiation, pigmentation and carcinogenesis. At least six categories of researchers will find this book essential, including stem cell, developmental, hair follicle or molecular biologists, and gerontologists or clinical dermatologists.

Microbial Population Genetics (Hardcover): Jianping Xu Microbial Population Genetics (Hardcover)
Jianping Xu
R5,677 Discovery Miles 56 770 Ships in 10 - 15 working days

Microbial population genetics is a rapidly advancing field of investigation with relevance to many areas of science. The subject encompasses theoretical issues, such as the origins and evolution of species, sex, and recombination. Population genetics lays the foundations for tracking the origin and evolution of antibiotic resistance and deadly infectious pathogens and is also an essential tool in the utilization of beneficial microbes. This invaluable book, written by leading researchers in the field, details the current major advances in microbial population genetics and genomics. Distinguished international scientists introduce fundamental concepts, describe genetic tools, and comprehensively review recent data from SNP surveys, whole-genome DNA sequences, and microarray hybridizations. The chapters cover broad groups of microorganisms including viruses, bacteria, archaea, fungi, protozoa, and algae. A major focus is the application of molecular tools in the study of genetic variation. Topics covered include microbial systematics, comparative microbial genomics, horizontal gene transfer, pathogenic bacteria, nitrogen-fixing bacteria, cyanobacteria, microalgae, fungi, malaria parasites, viral pathogens, and metagenomics. Microbial Population Genetics is an essential volume for everyone interested in population genetics, and it is highly recommended reading for all microbiologists.

Brachypodium Genomics - Methods and Protocols (Hardcover, 1st ed. 2018): Gaurav Sablok, Hikmet Budak, Peter J Ralph Brachypodium Genomics - Methods and Protocols (Hardcover, 1st ed. 2018)
Gaurav Sablok, Hikmet Budak, Peter J Ralph
R4,898 R3,753 Discovery Miles 37 530 Save R1,145 (23%) Ships in 12 - 19 working days

This volume presents protocols for Brachypodium genomics in numerous areas ranging from marker development, trait evolution, functional genomics, metabolomics, transcriptomics, genomics, and tilling. This book also explores techniques to study the widening genetic base of Brachypodium that will help researchers better understand the model plant using NGS technologies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Brachypodium Genomics: Methods and Protocols is a valuable resource for bench-oriented molecular biologists and computational biologists working towards further evolving this field.

Mendel's Principles of Heredity, by W. Bateson (Hardcover): William 1861-1926 Bateson, Gregor 1822-1884 Mendel Mendel's Principles of Heredity, by W. Bateson (Hardcover)
William 1861-1926 Bateson, Gregor 1822-1884 Mendel
R1,074 Discovery Miles 10 740 Ships in 12 - 19 working days
Alien Introgression in Wheat - Cytogenetics, Molecular Biology, and Genomics (Hardcover, 1st ed. 2015): Marta Molnar-Lang,... Alien Introgression in Wheat - Cytogenetics, Molecular Biology, and Genomics (Hardcover, 1st ed. 2015)
Marta Molnar-Lang, Carla Ceoloni, Jaroslav Dolezel
R6,310 R5,101 Discovery Miles 51 010 Save R1,209 (19%) Ships in 12 - 19 working days

This book provides an overview of the latest advancements in the field of alien introgression in wheat. The discovery and wide application of molecular genetic techniques including molecular markers, in situ hybridization, and genomics has led to a surge in interspecific and intergeneric hybridization in recent decades. The work begins with the taxonomy of cereals, especially of those species which are potential gene sources for wheat improvement. The text then goes on to cover the origin of wheat, breeding in connection with alien introgressions, and the problems of producing intergeneric hybrids and backcross derivatives. These problems can include crossability, sterility, and unequal chromosome transmission. The work then covers alien introgressions according to the related species used, as well as new results in the field of genomics of wild wheat relatives and introgressions.

Stem Cells, Pre-neoplasia, and Early Cancer of the Upper Gastrointestinal Tract (Hardcover, 1st ed. 2016): Marnix Jansen,... Stem Cells, Pre-neoplasia, and Early Cancer of the Upper Gastrointestinal Tract (Hardcover, 1st ed. 2016)
Marnix Jansen, Nicholas A. Wright
R4,482 Discovery Miles 44 820 Ships in 10 - 15 working days

This book is a comprehensive understanding of the evolution of pre-malignant disease, emphasizing common themes in the field, including stem cell biology and histologic modes of cancer progression between the distal esophagus and stomach. Its sixteen chapters discuss metaplastic tissue change in the upper GI, clonalexpansion of early neoplasia, stem cell dynamics in experimental models, pathology of early esophageal squamous cell carcinoma, therapeutic modalities for esophageal squamous cell carcinoma, pathology of Barrett's esophagus, screening, early detection and novel diagnostic tools for Barrett's esophagus, clonal evolution of Barrett's esophagus, endoscopic therapeutic modalities of early esophageal cancer, pathology of early gastric cancer, and experimental models for gastric cancer. Stem Cells, Pre-neoplasia and Early Cancer of the Upper Gastrointestinal Tract is an integrative text on both the current state of translational research on every cancer development of the upper gastrointestinal tract as well as on novel clinical diagnostic and therapeutic modalities. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike. Springer's Advances in Experimental Medicine and Biology series presents multidisciplinary and dynamic findings in the broad fields of experimental medicine and biology. The wide variety in topics it presents offers readers multiple perspectives on a variety of disciplines including neuroscience, microbiology, immunology, biochemistry, biomedical engineering and cancer research.

Genetics and the Unsettled Past - The Collision of DNA, Race, and History (Hardcover, New): Keith Wailoo, Alondra Nelson,... Genetics and the Unsettled Past - The Collision of DNA, Race, and History (Hardcover, New)
Keith Wailoo, Alondra Nelson, Catherine Lee
R3,164 Discovery Miles 31 640 Ships in 12 - 19 working days

Our genetic markers have come to be regarded as portals to the past. Analysis of these markers is increasingly used to tell the story of human migration; to investigate and judge issues of social membership and kinship; to rewrite history and collective memory; to right past wrongs and to arbitrate legal claims and human rights controversies; and to open new thinking about health and well-being. At the same time, in many societies genetic evidence is being called upon to perform a kind of racially charged cultural work: to repair the racial past and to transform scholarly and popular opinion about the "nature" of identity in the present. Genetics and the Unsettled Past considers the alignment of genetic science with commercial genealogy, with legal and forensic developments, and with pharmaceutical innovation to examine how these trends lend renewed authority to biological understandings of race and history. This unique collection brings together scholars from a wide range of disciplines-biology, history, cultural studies, law, medicine, anthropology, ethnic studies, sociology-to explore the emerging and often contested connections among race, DNA, and history. Written for a general audience, the book's essays touch upon a variety of topics, including the rise and implications of DNA in genealogy, law, and other fields; the cultural and political uses and misuses of genetic information; the way in which DNA testing is reshaping understandings of group identity for French Canadians, Native Americans, South Africans, and many others within and across cultural and national boundaries; and the sweeping implications of genetics for society today.

Advances in Genomics (Hardcover): Samuel D'Costa Advances in Genomics (Hardcover)
Samuel D'Costa
R3,437 R3,107 Discovery Miles 31 070 Save R330 (10%) Ships in 10 - 15 working days
RNA-Protein Complexes and Interactions - Methods and Protocols (Hardcover, 1st ed. 2016): Ren-Jang Lin RNA-Protein Complexes and Interactions - Methods and Protocols (Hardcover, 1st ed. 2016)
Ren-Jang Lin
R4,582 R3,725 Discovery Miles 37 250 Save R857 (19%) Ships in 12 - 19 working days

This detailed volume explores the continuing techniques of studying RNA-protein complexes and interactions as research in these areas expand. After an introductory chapter, the book continues with ways to purify RNA-protein complexes assembled in cells or in isolated cellular extracts, methods for measuring various biochemical activities of RNA-interacting proteins or ribonucleoproteins, biochemical methods for measuring direct RNA-protein contact, as well as various new or innovative methods pertinent to the subject. Written for the highly successful Methods in Molecular Biology series, chapters contain brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, RNA-Protein Complexes and Interactions: Methods and Protocols provides a set of useful protocols, both basic and advanced, designed to inspire researchers working with RNA and RNA-interacting proteins.

DNA Methylation and Complex Human Disease (Hardcover): Michel Neidhart DNA Methylation and Complex Human Disease (Hardcover)
Michel Neidhart
R2,926 R2,631 Discovery Miles 26 310 Save R295 (10%) Ships in 12 - 19 working days

DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease. Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. In addition, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases such as rheumatoid arthritis.

Sunflower - Chemistry, Production, Processing, and Utilization (Hardcover): Martinez-Force Enrique, Nurhan T. Dunford, Joaquin... Sunflower - Chemistry, Production, Processing, and Utilization (Hardcover)
Martinez-Force Enrique, Nurhan T. Dunford, Joaquin J. Salas
R4,623 Discovery Miles 46 230 Ships in 12 - 19 working days

This comprehensive reference delivers key information on all aspects of sunflower. With over 20 chapters, this book provides an extensive review of the latest developments in sunflower genetics, breeding, processing, quality, and utilization; including food, energy and industrial bioproduct applications. World-renowned experts in this field review U.S. and international practices, production, and processing aspects of sunflower.

Cell Biology and Translational Medicine, Volume 1 - Stem Cells in Regenerative Medicine: Advances and Challenges (Hardcover,... Cell Biology and Translational Medicine, Volume 1 - Stem Cells in Regenerative Medicine: Advances and Challenges (Hardcover, 1st ed. 2018)
Kursad Turksen
R3,634 Discovery Miles 36 340 Ships in 10 - 15 working days

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. With a goal to accelerate advances by timely information exchange, this new book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature's longstanding and very successful Advances in Experimental Medicine and Biology book series is launched. Emerging areas of regenerative medicine and translational aspects of stem cells will be covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the first volume of a continuing series.

Gene Essentiality - Methods and Protocols (Hardcover, 2015 ed.): Long Jason Lu Gene Essentiality - Methods and Protocols (Hardcover, 2015 ed.)
Long Jason Lu
R3,708 Discovery Miles 37 080 Ships in 12 - 19 working days

This volume opens by covering two main types of approaches widely used to determine essential genes: single-gene knockouts and transposon mutagenesis, in both prokaryotes and Candida albicans. Given the significant advancement in the computational predictions of microbial essential genes, the second half of the book examines four main types of approaches: comparative genomics, supervised machine learning, constraint-based methods, and corrections of transposon mutagenesis data, as well as databases and servers that are often used in studying gene essentiality. Written in the highly successful Methods in Molecular Biology series format, chapters include an introduction to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Gene Essentiality: Methods and Protocols will aid researchers who wish to further our knowledge in this vital field of study.

DNA Replication - Methods and Protocols (Hardcover, 2nd ed. 2015): Sonya Vengrova, Jacob Dalgaard DNA Replication - Methods and Protocols (Hardcover, 2nd ed. 2015)
Sonya Vengrova, Jacob Dalgaard
R4,929 R3,784 Discovery Miles 37 840 Save R1,145 (23%) Ships in 12 - 19 working days

Updated and revised, this thorough volume covers a range of methods focusing on systems, including mammalian, yeast, bacterial and archaeal. This second edition of DNA Replication: Methods and Protocols describes approaches to analyze whole genomes to single molecules, as well as both in vivo and in vitro experiments. As a volume in the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, DNA Replication: Methods and Protocols, Second Edition provides a collections of methods intended for newcomers to this research field and for established laboratories.

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