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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical)
This fourth volume in the Handbook of Stress series, Stress:
Genetics, Epigenetics and Genomics, deals with the influence that
genetics, epigenetics, and genomics have on the effects of and
responses to stress. Chapters refer to epigenetic mechanisms that
involve DNA methylation, histone modification, and/or noncoding
RNA-associated gene activation or silencing. There is also coverage
of epigenetic mechanisms in stress-related transgenerational
transmission of characteristics, and how these may help explain
heritability in some complex human diseases. The Handbook of Stress
series, comprised of self-contained volumes that each focus on a
specific stress area, covers the significant advances made since
the publication of Elsevier's Encyclopedia of Stress (2000 and
2007). Volume 4 is ideal for graduate students, post-doctoral
fellows, faculty and clinicians interested in stress genetics,
epigenetics and genomics involved in neuroendocrinology,
neuroscience, biomedicine, endocrinology, psychology, psychiatry
and the social sciences
For decades, Emery and Rimoin's Principles and Practice of Medical
Genetics and Genomics has served as the ultimate resource for
clinicians integrating genetics into medical practice. With nearly
5,000 pages of detailed coverage, contributions from over 250 of
the world's most trusted authorities in medical genetics, and a
series of 11 volumes available for individual sale, the Seventh
Edition of this classic reference includes the latest information
on seminal topics such as prenatal diagnosis, genome and exome
sequencing, public health genetics, genetic counseling, and
management and treatment strategies to complete its coverage of
this growing field for medical students, residents, physicians, and
researchers involved in the care of patients with genetic
conditions. This comprehensive yet practical resource emphasizes
theory and research fundamentals related to applications of medical
genetics across the full spectrum of inherited disorders and
applications to medicine more broadly. In Metabolic Disorders,
leading physicians and researchers thoroughly examine medical
genetics as applied to a range of metabolic disorders, with
emphasis on understanding the genetic mechanisms underlying these
disorders, diagnostic approaches, and therapeutics that make use of
current genomic technologies and translational studies. Here
genetic researchers, students, and health professionals will find
new and fully revised chapters on the genetic basis of body mass,
amino acid, carbohydrate, iron, copper, lipo protein, and lipid
metabolic disorders, as well as organic acidemias, fatty acid
oxidation, and peroxisome disorders among others. With regular
advances in genomic technologies propelling precision medicine into
the clinic, Emery and Rimoin's Principles and Practice of Medical
Genetics and Genomics: Seventh Edition bridges the gap between
high-level molecular genetics and practical application and serves
as an invaluable clinical tool for health professionals and
researchers.
This book explores the potential applications of animal stem cells
in veterinary medicine. It begins with an overview of stem cells
and their application in treating various animal diseases,
including mastitis. In turn, the book discusses the challenges of
using stem cells in regenerative medicine and emphasizes the
importance of understanding the action of stem cells and
preclinical evidence for ensuring safety and therapeutic efficacy.
It also presents methods for the identification, characterization,
and quantification of stem cells. Further, it discusses the
therapeutic applications of different stem cells, including
milk-derived, testicular, and mesenchymal stem cells in veterinary
medicine. Lastly, it discusses strategies for and therapeutic
applications of genome editing by CRISPER/Cas9 in mammary stem
cells. As such, the book offers a valuable resource for students
and scientists working in the veterinary sciences and
veterinarians.
How do genes determine behavior? How much of behavior is nature
versus nurture? How do behaviors evolve? Anholt and Mackay, leading
scholars in the field of behavioral genetics, address these
questions and much more in this comprehensive textbook that defines
the emerging field of behavioral genetics. The provides a range of
examples, such as laboratory studies on flies and mice, field
observations on species as diverse as butterflies and meerkats, and
human behavioral disorders. The book blends classical and modern
genetic principles with neurobiological and ecological perspectives
to teach students how to find and map genes that affect behaviors,
as well as how the coordinated expression of ensembles of these
genes enables the nervous system to express complex behaviors in
response to changes in the environment. Principles of Behavioral
Genetics introduces us to the fascinating science that aims to
understand how our genes determine what makes us tick.
Principles of Behavioral Genetics presents a comprehensive overview
of the relationship between genes, brain and behavior. Introductory
chapters provide clear explanations of basic processes of the
nervous system and fundamental principles of genetics of complex
traits without excessive statistical jargon. Individual chapters
describe the genetics of social interactions, olfaction and taste,
memory and learning, circadian behavior, locomotion, sleep, and
addiction, as well as the evolution of behavior. Whereas the focus
is on genetics, neurobiological and ecological aspects are also
included to provide intellectual breadth. The book uses examples
that span the gamut from classical model organisms to non-model
systems and human biology, and include both laboratory and field
studies. Samples of historical information accentuate the text to
provide the reader with an appreciation of the history of the
field. All chapters contain general overviews, concise summaries,
study questions that promote not only memorization but also
contemplation of the material, and recommendations for further
in-depth reading. An extensive glossary that defines the
terminology used in the book is included. This textbook encompasses
a broad definition of the emerging science of behavioral genetics.
* Defines the emerging science of behavioral genetics
* Engagingly written by two leading experts in behavioral
genetics
* Clear explanations of basic quantitative genetic, neurogenetic
and genomic applications to the study of behavior
* Numerous examples ranging from model organisms to non-model
systems and humans
* Concise overviews and summaries for each chapter
Histone Modifications in Therapy provides an in-depth analysis of
the role of histone mechanisms in major diseases and the promise of
targeting histone modifications for disease prevention and
treatment. Here, researchers, clinicians and students will discover
a thorough, evidence-based discussion of the biology of histones,
the diseases engaged by aberrant histone modifications, and
pathways with therapeutic potential. Expert chapter addresses the
role of histone modifications across a variety of disorders,
including cancer, neuropsychiatric, neurodegenerative, cardiac,
metabolic, infectious, bacterial, autoimmune and inflammatory
disorders, among others. In relation to these disease types,
histone modifications are discussed, both as mechanisms of
prevention and possible treatment. A concluding chapter brings
together future perspectives for targeting histone modifications in
therapy and next steps in research.
Transcription Factors for Abiotic Stress Tolerance in Plants
highlights advances in the understanding of the regulatory network
that impacts plant health and production, providing important
insights for improving plant resistance. Plant production worldwide
is suffering serious losses due to widespread abiotic stresses
increasing as a result of global climate change. Frequently more
than one abiotic stress can occur at once, for example extreme
temperature and osmotic stress, which increases the complexity of
these environmental stresses. Modern genetic engineering
technologies are one of the promising tools for development of
plants with efficient yields and resilience to abiotic stresses.
Hence deciphering the molecular mechanisms and identifying the
abiotic stress associated genes that control plant response to
abiotic stresses is a vital requirement in developing plants with
increased abiotic stress resilience. Addressing the various
complexities of transcriptional regulation, this book includes
chapters on cross talk and central regulation, regulatory networks,
the role of DOF, WRKY and NAC transcription factors, zinc finger
proteins, CRISPR/CAS9-based genome editing, C-Repeat (CRT) binding
factors (CBFs)/Dehydration responsive element binding factors
(DREBs) and factors impacting salt, cold and phosphorous stress
levels, as well as transcriptional modulation of genes involved in
nanomaterial-plant interactions. Transcription Factors for Abiotic
Stress Tolerance in Plants provides a useful reference by
unravelling the transcriptional regulatory networks in plants.
Researchers and advanced students will find this book a valuable
reference for understanding this vital area.
This open access volume presents state-of-the-art inference methods
in population genomics, focusing on data analysis based on rigorous
statistical techniques. After introducing general concepts related
to the biology of genomes and their evolution, the book covers
state-of-the-art methods for the analysis of genomes in
populations, including demography inference, population structure
analysis and detection of selection, using both model-based
inference and simulation procedures. Last but not least, it offers
an overview of the current knowledge acquired by applying such
methods to a large variety of eukaryotic organisms. Written in the
highly successful Methods in Molecular Biology series format,
chapters include introductions to their respective topics, pointers
to the relevant literature, step-by-step, readily reproducible
laboratory protocols, and tips on troubleshooting and avoiding
known pitfalls. Authoritative and cutting-edge, Statistical
Population Genomics aims to promote and ensure successful
applications of population genomic methods to an increasing number
of model systems and biological questions.
The book presents comprehensive information on fundamental, and
applied knowledge for developing varieties resistant individually
as well as to all the major pathogens of crucifers, such as Albugo,
Alternaria, Erysiphe, Hyaloperonospora, Plasmodiophora,
Leptosphaeria, Sclerotinia, Turnip mosaic virus, Verticillium, and
Xanthomonas through the use of latest biotechnological approaches
including identification of R genes and their incorporation into
agronomically superior varieties. The chapters include the
information's viz., principles of host resistance, identification
of R-genes sources, inheritance of disease resistance, host
resistance signaling network system to multiple stresses. The book
also covers transfer of disease resistance, and management of
disease resistance. Standardized, reproducible techniques are also
included for the researchers of cruciferous crops for developing
resistant cultivars. The book deals with the gaps in understanding,
knowledge of genomics, and offers suggestions for future research
priorities in order to initiate the advance research on disease
resistance. This book is immensely useful to the researchers
especially Brassica breeders, teachers, extension specialists,
students, industrialists, farmers, and all others who are
interested to grow healthy, and profitable cruciferous crops all
over the world.
Responsible Genomic Data Sharing: Challenges and Approaches brings
together international experts in genomics research, bioinformatics
and digital security who analyze common challenges in genomic data
sharing, privacy preserving technologies, and best practices for
large-scale genomic data sharing. Practical case studies, including
the Global Alliance for Genomics and Health, the Beacon Network,
and the Matchmaker Exchange, are discussed in-depth, illuminating
pathways forward for new genomic data sharing efforts across
research and clinical practice, industry and academia.
Secondary Findings in Genomic Research offers a single, highly
accessible resource on interpreting, managing and disclosing
secondary findings in genomic research. With chapters written by
experts in the field, this book is the first to concisely explain
the ethical and practical issues raised by secondary genomics
findings for a multi and interdisciplinary audience of genomic
researchers, translational scientists, clinicians, medical
students, genetic counselors, ethicists, legal experts and law
students, public policy specialists and regulators. Contributors
from Europe, North America, and Asia effectively synthesize
perspectives from a spectrum of different scientific, societal, and
global contexts, and offer pragmatic approaches to a range of
topics, including oversight, governance and policy surrounding
secondary genomic results, criteria for identifying results for
return, communication and consent, stakeholders' attitudes and
perspectives, disclosing results, and clinical, patient-centered
protocols.
Microbiomics: Dimensions, Applications, and Translational
Implications of Human and Environmental Microbiome Research
describes a new, holistic approach to microbiomics. International
experts provide in-depth discussion of current research methods for
studying human, environmental, viral and fungal microbiomes, as
well as the implications of new discoveries for human health,
nutrition, disease, cancer research, probiotics and in the food and
agricultural industries. Distinct chapters covering culturomics and
sub-microbiomes, such as the viriome and mycetobiome, provide an
integrative framework for the expansion of microbiomics into new
areas of application, as well as crosspollination between research
areas. Detailed case studies include the use of microbiomics to
develop natural products with antimicrobial properties, microbiomic
enhancements in food and beverage technology, microbes for
bioprotection and biopreservation, microbial tools to reduce
antibiotic resistance, and maintenance and cultivation of human
microbial communities.
This volume provides comprehensive information on how mapping an
individual's epigenome can be medically relevant and holds the
potential to improve preventive medicine and precision therapeutics
at an early-stage (prior to disease onset). In order to advance
clinical adoption of the recently developed epigenetic approaches,
it is necessary for translational scientists, clinicians, and
students to gain a better understanding about epigenetic mechanisms
that are associated with a particular disorder; and to be able to
effectively identify biomarkers that can be applied in drug
development and for better diagnosis and prognosis of diseases.
Prognostic Epigenetics is the most-inclusive volume to-date
specifically dedicated to epigenetic markers that have been
developed for prognosis of diseases, recent advances in this field,
the clinical implementation of this research, and the future
outlook.
This book offers an essential introduction to the latest advances
in delayed genetic regulatory networks (GRNs) and presents
cutting-edge work on the analysis and design of delayed GRNs in
which the system parameters are subject to uncertain, stochastic
and/or parameter-varying changes. Specifically, the types examined
include delayed switching GRNs, delayed stochastic GRNs, delayed
reaction-diffusion GRNs, delayed discrete-time GRNs, etc. In
addition, the solvability of stability analysis, control and
estimation problems involving delayed GRNs are addressed in terms
of linear matrix inequality or M-matrix tests. The book offers a
comprehensive reference guide for researchers and practitioners
working in system sciences and applied mathematics, and a valuable
source of information for senior undergraduates and graduates in
these areas. Further, it addresses a gap in the literature by
providing a unified and concise framework for the analysis and
design of delayed GRNs.
Translational Systems Medicine and Oral Disease bridges the gap
between discovery science and clinical oral medicine, providing
opportunities for both the scientific and clinical communities to
understand how to apply recent findings in cell biology, genomic
profiling, and systems medicine to favorably impact the diagnosis,
treatment and management of oral diseases. Fully illustrated
chapters from leading international contributors explore clinical
applications of genomics, proteomics, metabolomics, microbiomics
and epigenetics, as well as analytic methods and functional omics
in oral medicine. Disease specific chapters detail systems
approaches to periodontal disease, salivary gland diseases, oral
cancer, bone disease, and autoimmune disease, among others. In
addition, the book emphasizes biological synergisms across
disciplines and their translational impact for clinicians,
researchers and students in the fields of dentistry, dermatology,
gastroenterology, otolaryngology, oncology and primary care.
Emery and Rimoin's Principles and Practice of Medical Genetics and
Genomics: Cardiovascular, Respiratory, and Gastrointestinal
Disorders, Seventh Edition includes the latest information on
seminal topics such as prenatal diagnosis, genome and exome
sequencing, public health genetics, genetic counseling, and
management and treatment strategies. This comprehensive, yet
practical, resource emphasizes theory and research fundamentals
relating to applications of medical genetics across the full
spectrum of inherited disorders and applications to medicine.
Updated sections in this release cover the genetics of
cardiovascular, respiratory and gastrointestinal disorders, with an
emphasis on genetic determinants and new pathways for diagnosis,
prevention and disease management. In addition, genetic
researchers, students and health professionals will find new and
fully revised chapters on the molecular genetics of congenital
heart defects, inherited cardiomyopathies, hypertension, cystic
fibrosis, asthma, hereditary pulmonary emphysema, inflammatory
bowel disease, and bile pigment metabolism disorders among other
conditions.
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