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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical)

The Problem of Mental Deficiency - Eugenics, Democracy, and Social Policy in Britain, c.1870-1959 (Hardcover, New): Mathew... The Problem of Mental Deficiency - Eugenics, Democracy, and Social Policy in Britain, c.1870-1959 (Hardcover, New)
Mathew Thomson
R5,625 Discovery Miles 56 250 Ships in 12 - 19 working days

This is the first detailed assessment of the development and implementation of social policy to deal with the problem of the `mentally deficient' in Britain between 1870 and 1959. Mathew Thomson analyses all the factors involved in the policy-making process, beginning with the politics of the legislature and showing how the demands of central government were interpreted by local authorities, resulting in a wide and varied distribution of medical, institutional, and community care in different parts of the country. The efforts of health professionals, voluntary organizations and the families themselves are considered, alongside questions about the influence of changing concepts of class, gender, and citizenship. The author queries the belief that the policy of segregation was largely unsuccessful, and reveals a hitherto unrecognized system of care in the community. He reframes our understanding of the campaign for sterilization and examines why British policy-makers avoided extremist measures such as the compulsory sterilization introduced in Germany and parts of the US during this period. Thomson shows that the problem of mental deficiency cannot be understood simply in terms of eugenics but must also be considered as part of the process of adjusting to democracy in the twentieth century.

Understanding Animal Genetics (Hardcover): Dominic Fasso Understanding Animal Genetics (Hardcover)
Dominic Fasso
R3,456 R3,126 Discovery Miles 31 260 Save R330 (10%) Ships in 10 - 15 working days
Genetic Engineering of DNA and Protein: Volume I (Hardcover): Tom Lee Genetic Engineering of DNA and Protein: Volume I (Hardcover)
Tom Lee
R2,493 R2,273 Discovery Miles 22 730 Save R220 (9%) Ships in 10 - 15 working days
New War Technologies and International Law - The Legal Limits to Weaponising Nanomaterials (Hardcover): Kobi Leins New War Technologies and International Law - The Legal Limits to Weaponising Nanomaterials (Hardcover)
Kobi Leins
R3,116 Discovery Miles 31 160 Ships in 12 - 19 working days

The desire for humanity and the desire for security have co-existed as long as humans have been alive. As science has become increasingly sophisticated, so have the methods of self-defence by States. Nanotechnology is already changing warfare by increasing capabilities upon which armed forces are heavily reliant: more efficient energy storage, advanced photovoltaics, and improved military protective equipment to name a few of these developments. Some applications of nanomaterials by the military are both powerful and subtle, and have neurological and biological applications: 'devices that can infiltrate electronics and seize control at crucial moments, artificial "disease" agents that can rest harmlessly in victims' bodies until activated by an external signal'. The advance of the use or contemplation of use of these types of nanoscale applications by the military requires urgent analysis in light of existing international law, particularly in light of their potential effects on humans and on the environment.

Stromal Signaling in Cancer, Volume 154 (Hardcover): Peggi Angel, Michael Ostrowski Stromal Signaling in Cancer, Volume 154 (Hardcover)
Peggi Angel, Michael Ostrowski
R4,709 R3,944 Discovery Miles 39 440 Save R765 (16%) Ships in 12 - 19 working days

Stromal Signaling in Cancer, Volume 154 in the Advances in Cancer Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics surrounding cancer research. Each chapter is written by an international board of authors.

Genetic Engineering of DNA and Protein: Volume II (Hardcover): Tom Lee Genetic Engineering of DNA and Protein: Volume II (Hardcover)
Tom Lee
R2,507 R2,286 Discovery Miles 22 860 Save R221 (9%) Ships in 10 - 15 working days
DNA Repair: Novel Insights (Hardcover): Nas Wilson DNA Repair: Novel Insights (Hardcover)
Nas Wilson
R2,733 R2,485 Discovery Miles 24 850 Save R248 (9%) Ships in 10 - 15 working days
DNA Replication (Hardcover): Tom Lee DNA Replication (Hardcover)
Tom Lee
R2,724 R2,476 Discovery Miles 24 760 Save R248 (9%) Ships in 10 - 15 working days
Tumor Microenvironment - Extracellular Matrix Components - Part B (Hardcover, 1st ed. 2020): Alexander Birbrair Tumor Microenvironment - Extracellular Matrix Components - Part B (Hardcover, 1st ed. 2020)
Alexander Birbrair
R4,371 Discovery Miles 43 710 Ships in 10 - 15 working days

Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on the extracellular matrix components of the tumor microenvironment during cancer development. Furthermore, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include elastin, decorin, syndecan-1, versican, lipoproteins, brevican, thrombospondin, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Extracellular Matrix Components - Part B updates us on what we know about the different aspects of the tumor microenvironment, as well as apprises us on the future advances in the field. For the newest generation of researchers, this volume serves as a useful introduction to the history of scientists' focus on the tumor microenvironment, and explores how this knowledge is currently applied in cancer treatments. The book is an essential text for advanced cell biology and cancer biology students, as well as for scientists seeking an update on the developments in tumor microenvironment research. All of the chapters authors are renowned international experts in the field of cancer biology, and in the specific subfields that are the focus of their chapters.

Genetic Engineering (Hardcover): David Rhodes Genetic Engineering (Hardcover)
David Rhodes
R1,818 R1,680 Discovery Miles 16 800 Save R138 (8%) Ships in 10 - 15 working days
DNA Repair: Advanced Concepts (Hardcover): Nas Wilson DNA Repair: Advanced Concepts (Hardcover)
Nas Wilson
R2,504 R2,283 Discovery Miles 22 830 Save R221 (9%) Ships in 10 - 15 working days
Insect Genomics - Methods and Protocols (Hardcover, 1st ed. 2019): Susan J. Brown, Michael E. Pfrender Insect Genomics - Methods and Protocols (Hardcover, 1st ed. 2019)
Susan J. Brown, Michael E. Pfrender
R4,398 Discovery Miles 43 980 Ships in 10 - 15 working days

This volume focuses on the latest methods used to sequence, assemble, and analyze insect genomes. The collection of protocols in this book provides an introduction to the workflows and bioinformatics tools available for researchers. The chapters cover a range of useful topics such as determining genome size by flow cytometry; High Molecular Weight DNA extraction; improvements to a genome assembly provided by long-range sequencing approaches; assessments of orthology and single-copy genes at different phylogenetic levels; detecting regulatory regions with FAIRE, RAMPAGE, and computational analysis of cis-regulatory modules in insects; bioinformatics analysis of epigenetic modifications, high-throughput scanning of insect genomes (TEEseq) for the presence of endosymbionts, and leveraging genome sequence information to design RNAi strategies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Insect Genomics: Methods and Protocols is a valuable resource for graduate students, postdocs, and novice research scientists who are interested in learning more about this developing field.

Innovations in Molecular Mechanisms and Tissue Engineering (Hardcover, 1st ed. 2016): Jeanne Wilson-Rawls, Kenro Kusumi Innovations in Molecular Mechanisms and Tissue Engineering (Hardcover, 1st ed. 2016)
Jeanne Wilson-Rawls, Kenro Kusumi
R4,862 Discovery Miles 48 620 Ships in 12 - 19 working days

This book marries stem cell biology, tissue engineering, and regenerative biology into a single, interdisciplinary volume. The chapters also explore embryonic stem cells, induced pluripotent stem cells, cardiovascular regeneration, skeletal development, inflammation, polymeric biomaterials, neural injury, cartilage regeneration, regeneration in ambystoma, models for regeneration using salamander and zebrafish, and more. The volume also discusses recent advances and their potential in developing future therapies. Innovations in Molecular Mechanisms and Tissue Engineering combines perspectives from the biomedical, bioengineering, and medical fields to present a cutting-edge, multifaceted picture of the tissue engineering and regenerative medicine fields. This installment of Springer's Stem Cell Biology and Regenerative Medicine series is ideal for scientists, clinicians, and researchers in the fields of stem cell biology, regenerative medicine, biomedical engineering, and tissue engineering.

The Bitter Gourd Genome (Hardcover, 1st ed. 2020): Chittaranjan Kole, Hideo Matsumura, Tusar Kanti Behera The Bitter Gourd Genome (Hardcover, 1st ed. 2020)
Chittaranjan Kole, Hideo Matsumura, Tusar Kanti Behera
R2,892 Discovery Miles 28 920 Ships in 10 - 15 working days

This book focusing on the bitter gourd genome is the first comprehensive compilation of knowledge on the botany, cytogenetical analysis, genetic resources and diversity, traditional breeding, tissue culture and genetic transformation, whole genome sequencing and comparative genomics in the Cucurbitaceae family. It discusses the biochemical profile of the bioactives present in this horticultural crop, used both as a vegetable and as a medicine, and also addresses sex determination in bitter gourd. Written by respected international experts, the book is useful to students, teachers and scientists in academia, as well as seed companies and pharmaceutical industries.

Intracellular Protein Degradation, Volume 27 (Hardcover): A. J. Rivett Intracellular Protein Degradation, Volume 27 (Hardcover)
A. J. Rivett
R2,910 Discovery Miles 29 100 Ships in 12 - 19 working days

This volume brings together a set of reviews that provide a summary of our current knowledge of the proteolytic machinery and of the pathways of protein breakdown of prokaryotic and eukaryotic cells. Intracellular protein degradation is much more than just a mechanism for the removal of incorrectly folded or damaged proteins. Since many short-lived proteins have important regulatory functions, proteolysis makes a significant contribution to many cellular processes including cell cycle regulation and transciptional control. In addition, limited proteolytic cleavage can provide a rapid and efficient mechanism of enzyme activation or inactivation in eukaryotic cells.
In the first chapter, Maurizi provides an introduction to intracellular protein degradation, describes the structure and functions of bacterial ATP-dependent proteases, and explores the relationship between chaperone functions and protein degradation. Many of the principles also apply to eukaryotic cells, although the proteases involved are often not the same. Interestingly, homologues of one of the bacterial proteases, Ion protease, have been found in mitochondria in yeast and mammals, and homologues of proteasomes, which are found in all eukaryotic cells (see below), have been discovered in some eubacteria.
Studies of proteolysis in yeast have contributed greatly to the elucidation of both lysosomal (vacuolar) and nonlysosomal proteolytic pathways in eukaryotic cells. Thumm and Wolf (chapter 2) describe studies that have elucidated the functions of proteasomes in nonlysosomal proteolysis and the contributions of lysosomal proteases to intracellular protein breakdown. Proteins can be selected for degradation by a variety of differen mechanisms. The ubiquitin system is one complex and highly regulated mechanism by which eukaryotic proteins are targetted for degradation by proteosomes. In chapter 3, Wilkinson reviews the components and functions of the ubiquitin system and considers some of the known substrates for this pathway which include cell cycle and transcriptional regulators.
The structure and functions of proteosomes and their regulatory components are described in the two subsequent chapters by Tanaka and Tanahashi and by Dubiel and Rechsteiner. Proteasomes were the first known example of threonine proteases. They are multisubunit complexes that, in addition to being responsible for the turnover of most short-lived nuclear and cytoplasmic protein, are also involved in antigen processing for presentation by the MHC class I pathway. Recent studies reviewed by McCracken and colleagues (chapter 6) lead to the exciting conclusion that some ER-associated proteins are degraded by cytosolic proteasomes.
Lysosomes are responsible for the degradation of long-lived proteins and for the enhanced protein degradation observed under starvation conditions. In chapter 7 Knecht and colleagues review the lysosomal proteases and describe studies of the roles of lysosomes and the mechanisms for protein uptake into lysosomes. Methods of measuring the relative contribution of different proteolytic systems (e.g., ubiquitin-proteasome pathway, calcium-dependent proteases, lysosomes) to muscle protein degradation, and the conclusions from such studies, are reviewed by Attai and Taillinder in the following chapter.
Finally, proteases play an important role in signaling apoptosis by catalyzing the limited cleavage of enzymes. Mason and Beyette review the role of the major players, caspases, which are both activated by and catalyze limite proteolysis, and also consider the involvement of other protoelytic enzymes in this pathway leading cell death.

Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma (Hardcover, 1st ed. 2017): Juan Pedro... Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma (Hardcover, 1st ed. 2017)
Juan Pedro Martinez-Barbera, Cynthia Lilian Andoniadou
R3,818 R3,536 Discovery Miles 35 360 Save R282 (7%) Ships in 12 - 19 working days

This astute volume brings together the latest expert research on adamantinomatous craniopharyngiomas (ACPs). ACPs are histologically benign but clinically aggressive tumors exhibiting a high propensity for local invasion into the hypothalamus, optic and vascular structures. These tumors, as well as the current treatments, may result in pan-hypopituitarism, diabetes insipidus, morbid obesity followed by type II diabetes mellitus, blindness, as well as serious behavioral and psychosocial impairments. Exploring in detail advances in both the understanding of tumor biology as well as clinical advances in patient management are explored in detail, this book will also look towards potential new treatment approaches. Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma is the first book compiling all current research on ACPs. Mouse and human studies have unequivocally demonstrated that mutations in CTNNB1 encoding -catenin underlie the etiology of the majority, if not all ACP tumors. Genetic studies in mice have shown that ACPs are tumors of the pituitary gland and not of the hypothalamus as previously thought, and are derived from Rathke's pouch precursors. In addition, a role for tissue-specific adult pituitary stem cells has been revealed as causative of ACP. Together, these studies have provided novel insights into the molecular and cellular etiology as well as the pathogenesis of human ACP. Finally, this volume covers new treatment approaches that have been shown to be effective both in reducing ACP burden as well as reducing the morbidity associated with therapy.

Liver, Lung and Heart Regeneration (Hardcover, 1st ed. 2017): Phuc Van Pham Liver, Lung and Heart Regeneration (Hardcover, 1st ed. 2017)
Phuc Van Pham
R3,818 R3,536 Discovery Miles 35 360 Save R282 (7%) Ships in 12 - 19 working days

This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in liver, lung and heart regeneration. All chapters are contributed by pre-eminent scientists in the field and covers such topics as cell therapy in the treatment of cirrhosis and other liver, heart and lung diseases, characteristics of hepatic progenitor cells, future directions of the discussed therapies and much more. Liver, Lung and Heart Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.

The Tangled Tree - A Radical New History of Life (Paperback): David Quammen The Tangled Tree - A Radical New History of Life (Paperback)
David Quammen
R527 R498 Discovery Miles 4 980 Save R29 (6%) Ships in 10 - 15 working days
A Breeder's Guide to Genetics - Relax, it's Not Rocket Science (Hardcover): Ingrid Wood, Denise Como A Breeder's Guide to Genetics - Relax, it's Not Rocket Science (Hardcover)
Ingrid Wood, Denise Como
R877 Discovery Miles 8 770 Ships in 12 - 19 working days
Transgenic Fish (Hardcover): C.L. Hew, G.L. Fletcher Transgenic Fish (Hardcover)
C.L. Hew, G.L. Fletcher
R3,326 Discovery Miles 33 260 Ships in 12 - 19 working days
The Genetics Revolution - History, Fears, and Future of a Life-Altering Science (Hardcover): Rose Morgan The Genetics Revolution - History, Fears, and Future of a Life-Altering Science (Hardcover)
Rose Morgan
R1,929 Discovery Miles 19 290 Ships in 10 - 15 working days

What will our lives be like fifty years from now? What will we know about ourselves as humans, and how will that affect our lives? It's impossible to know the future for certain, but one thing we do know--perhaps nothing will alter our future more than the Genetics Revolution of the past thirty-five years. This book clarifies the history and examines the possible impact of five major areas of genetic research:

  • The Human Genome Project and genetic engineering
  • In vitro fertilization (IVF) and the technology of reproduction
  • The Human Genome Diversity Project, which is studying the variation of the human genome
  • Embryonic stem-cell research
  • Cloning
All of these areas of research produce two reactions among the general public--hope for the improvement of people's lives, and fear of science out of control. The Genetics Revolution examines the scientific, social, and political impacts of the genetics on everyday life--in the past, in the present, and in the future. Each specific topic is contained within its own chapter for ease in accessing specific information. This is an ideal resource for students, teachers, and others preparing research papers. In addition, it integrates science and social science topics in a way that supports topics in the school curricula. The book contains documented, current information that both supports and challenges current thinking about genetics.
Maize Germplasm - Characterization and Genetic Approaches for Crop Improvement (Hardcover): Mohamed El-Esawi Maize Germplasm - Characterization and Genetic Approaches for Crop Improvement (Hardcover)
Mohamed El-Esawi
R2,770 Discovery Miles 27 700 Ships in 10 - 15 working days
Pancreas, Kidney and Skin Regeneration (Hardcover, 1st ed. 2017): Phuc Van Pham Pancreas, Kidney and Skin Regeneration (Hardcover, 1st ed. 2017)
Phuc Van Pham
R5,032 Discovery Miles 50 320 Ships in 12 - 19 working days

This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in diabetes, kidney and wound treatment. All chapters are contributed by pre-eminent scientists in the field and covers such topics as stem cells and cell therapy in the treatment of diabetes mellitus, kidney failure, wound and other skin aging diseases, characteristics of some kinds of stem/progenitor cells for therapy, future directions of the discussed therapies and much more. Pancreas, Kidney and Skin Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.

Breeding Grasses and Protein Crops in the Era of Genomics (Hardcover, 1st ed. 2018): Gintaras Brazauskas, Grazina... Breeding Grasses and Protein Crops in the Era of Genomics (Hardcover, 1st ed. 2018)
Gintaras Brazauskas, Grazina Statkeviciute, Kristina Jonaviciene
R2,047 Discovery Miles 20 470 Ships in 12 - 19 working days

This book includes papers presented at the 2017 Joint meeting of Fodder Crops and Amenity Grasses Section and Protein Crops Working Group of EUCARPIA-Oil and Protein Crops Section. The theme of the meeting "Breeding Grasses and Protein Crops in the Era of Genomics" has been divided into six parts: (1) Utilisation of genetic resources and pre-breeding, (2) Genetic improvement of quality and agronomic traits, (3) Breeding for enhanced stress tolerance (4) Implementation of phenomics and biometrics, (5) Development of genomic tools and bioinformatics and (6) Reports of Parallel Sessions.

The Wonder of Life - Follow man's ignorance of the secrets of life to the marvels of today's DNA, the genetic code... The Wonder of Life - Follow man's ignorance of the secrets of life to the marvels of today's DNA, the genetic code and the genome of man. (Hardcover)
John Husher
R634 Discovery Miles 6 340 Ships in 12 - 19 working days

The Wonder of Life takes you from Earth's beginning and describes the events that preceded man and carries you along the path of man's education. This came through wars, then religion, and always through the silent killers of man as disease became one of the major carriers of education as well as death. You will journey through the battles with the silent killers and understand how man went from a defensive mode to one of the aggressor with the invention of the microscope. Follow the progress of the wins over the Staff infections, to the use of penicillin during the war and then the defeat of Polio; always in the search of what made man tick. This carries him through the discovery of DNA, the genetic code, AIDS, the human genome and to today's great hope of the use of stem cells to correct for the body's malfunction of its organs. It's an exciting story told in a novel manner for the layman to understand.

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