|
|
Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical)
This document is exclusively dedicated to DNA. It explains the
secrets of DNA from all corners. Presented in a simple, lucid
manner; it will useful to all involved in bioscience. In all it
consists 12 chapters, figures, photos and a wholesome glossary of
the terms related to DNA.
Reciprocity in Population Biobanks: Relational Autonomy and the
Duty to Inform in the Genomic Era begins by discussing how current
judicial interpretation keeps standard of disclosure at the core of
genomic research. The book then outlines multiple limitations
individualistic autonomy faces in the context of gene and
population biobanks, including an analysis of the complexities of
benefit considerations in the research setting. Second, the book
explores how individualistic autonomy fails to acknowledge the
multilateral relationships implicated in genomic research,
including those that affect the broader research community,
research participants' families, and the general public. In
carrying out this analysis, this book pays special attention to
alternative approaches and ways researchers, public health
officials, and judicial bodies might interact in years to come. In
other words, implementing an understanding of relational autonomy
that acknowledges and sustains the multilateral relationships found
in genomic research without compromising the rights of
participants. In short, this book proposes a reconceived duty to
inform for researchers and a new standard of disclosure that is
more meaningful and impactful for research participants and
researchers.
Genetics and Neurobiology of Down Syndrome provides a thorough
review of the genetic etiology and mechanisms of trisomy 21. The
author discusses the history of the syndrome, along with the
clinical features and health consequences, including physical
features, cognitive, and neurologic symptoms. Genetic counseling on
pros and cons of prenatal screening and testing and associated
ethical issues are explored. This unique book also covers the
societal and demographic aspects as well as the future direction of
therapeutic development.
he book deals essentially with the aspects that are of immediate
concern to new researchers in the filed of botanicals and natural
products. It presents the first comprehensive overview of the plant
products since they were introduces in the pest management covering
both theoretical and practical applications. This book covers the
key aspects of the plant products including ; natural pest
management agents from plant, extraction of plant products,
characterization and formulation and bioassay of extracts, a study
on the stability of the prepared extracts towards their various
biological activity against different microbial and stored grain
pests through a large number of the prepared extracts and
formulations in both water and organic media.
Emery and Rimoin's Principles and Practice of Medical Genetics and
Genomics: Perinatal and Reproductive Genetics, Seventh Edition
includes the latest information on seminal topics such as prenatal
diagnosis, genome and exome sequencing, public health genetics,
genetic counseling, and management and treatment strategies in this
growing field. The book is ideal for medical students, residents,
physicians and researchers involved in the care of patients with
genetic conditions. This comprehensive, yet practical resource
emphasizes theory and research fundamentals related to applications
of medical genetics across the full spectrum of inherited disorders
and applications to medicine more broadly. Chapters from leading
international researchers and clinicians focus on topics ranging
from single gene testing to whole genome sequencing, whole exome
sequencing, gene therapy, genome editing approaches, FDA
regulations on genomic testing and therapeutics, and ethical
aspects of employing genomic technologies.
Epigenetics and Metabolomics, a new volume in the Translational
Epigenetics series, offers a synthesized discussion of epigenetic
control of metabolic activity, and systems-based approaches for
better understanding these mechanisms. Over a dozen chapter authors
provide an overview of epigenetics in translational medicine and
metabolomics techniques, followed by analyses of epigenetic and
metabolomic linkage mechanisms likely to result in effective
identification of disease biomarkers, as well as new therapies
targeting the removal of the inappropriate epigenetic alterations.
Epigenetic interventions in cancer, brain damage, and
neuroendocrine disease, among other disorders, are discussed
in-depth, with an emphasis on exploring next steps for clinical
translation and personalized healthcare.
Scientific Principles of Adipose Stem Cells provides readers with
in-depth and expert knowledge on adipose stem cells, their
developmental biologic origins, foundational research on ASC
signaling mechanisms and immunomodulatory properties, and clinical
insights into applications in regenerative medicine. Topics covered
include basic adipose stem cell developmental biology and
mechanisms of regulating self-renewal and activation in the stem
cell niche, important methods for isolation and characterizing
ASCs, and data on the impact on human demographics (age, sex, BMI)
on ASC phenotype. A section devoted to ASC biology, ASCs for stem
cell therapy and regenerative medicine, and ASCs in tissue
engineering applications are also included. The book is written for
scientists and clinicians who are broadly familiar with stem cells
and basic cell biology principles and those seeking advanced
information on adipose stem cells.
Epigenetics of Stress and Stress Disorders, a new volume in the
Translational Epigenetics series, examines the epigenetic
mechanisms involved in modifying DNA following prolonged stress or
trauma. This is accomplished through the evaluation of both the
physiological and molecular effects of stress on the body that can
eventually lead to stress disorders. The book begins by providing a
psychiatric, biological, and phenomenological foundation for
understanding stress disorders, before delving into the genomics of
stress disorders. From here, chapter authors discuss a range of
recent epigenetic research in the area, highlighting epigenome-wide
association studies (EWAS), exciting developments in noncoding RNA
studies, possible effects of prolonged stress on telomere
shortening, and the long-term physical effects of PTSD on the
health of patients. The book also examines the effect of adversity
during sensitive periods or development and across the life span.
The book concludes by looking at possible transgenerational
stress-induced epigenetic alterations on future offspring and
important areas of research for public health, along with the
potential for epigenetic therapeutics or "epidrugs."
The brains of males and females, men and women, are different, that
is a fact. What is debated is how different and how important are
those differences. Sex differences in the brain are determined by
genetics, hormones, and experience, which in humans includes
culture, society, and parental and peer expectations. The
importance of nonbiological variables to sex differences in humans
is paramount, making it difficult if not impossible to parse out
those contributions that are truly biological. The study of animals
provides us the opportunity to understand the magnitude and scope
of biologically based sex differences in the brain, and
understanding the cellular mechanisms provides us insight into
novel sources of brain plasticity. Many sex differences are
established during a developmental sensitive window by differences
in the hormonal milieu of males versus females. The neonatal testis
produces large amounts of testosterone which gains access to the
brain and is further metabolized into active androgens and
estrogens which modify brain development. Major parameters that are
influenced by hormones include neurogenesis, cell death,
neurochemical phenotype, axonal and dendritic growth, and
synaptogenesis. Variance in these parameters results in sex
differences in the size of particular brain regions, the
projections between brain regions, and the number and type of
synapses within particular brain regions. The cellular mechanisms
are both region and endpoint specific and invoke many surprising
systems such as prostaglandins, endocannabinoids, and cell death
proteins. Epigenetic modifications to the genome both establish and
maintain sex differences in the brain and behavior. By
understanding when, why, and how sex differences in the brain are
established, we may also learn the source of strong gender biases
in the relative risk and severity of numerous neurological diseases
and disorders of mental health. Boys are much more likely to be
diagnosed with autism spectrum or attention and hyperactivity
disorders, as well as speech and language deficits, compared to
girls. By contrast, women are more likely to suffer from affective
disorders, such as depression, anxiety, compulsion, and eating
disorders and more likely to experience autoimmune and
neurodegenerative disorders. Schizophrenia with an early onset is
more common in males but a late-onset version is markedly more
frequent in females. Male biased disorders have origins in
development while female biased disorders are almost exclusively
post-puberty. This remarkable shift in disease risk demands our
attention. Novel insights into the biological origins of disease
are also gained by comparing and contrasting the same processes in
different sexes.
Twin and Family Studies of Epigenetics, Volume 27, the latest
release in the Translational Epigenetics series, gathers expert
opinions on epigenetic twin and family study research methods,
recent findings across various disease areas, and future
directions. The book provides in-depth coverage of epigenetics
fundamentals, twin and family epigenetic study design, and the
broader role of epigenetics in answering questions on the
developmental origins of health and disease. Throughout the volume,
twin and family studies are employed to examine causes of
epigenetic variation, the relationship between epigenetic
modifications and mental illness, cancers, cardiovascular disease,
diabetes, obesity, high blood pressure, and more. Emerging research
methods applied in twin and family studies discussed include
imaging epigenetics, exposure-specific DNA methylation changes, and
unravelling time trends in epigenetic effects.
Non-coding RNAs potentially play an active role in modulating gene
transcription and epigenetic states. Several genes in
differentiated cells may be under some form of RNA based
transcriptional and epigenetic regulatory control. This form of
regulation may be controlled by selective pressures and influence
the adaptability of the cell. The concept that RNA can control
epigenetic states impacts on our understanding of the basic fabric
of the cell and may have therapeutic potential. Many studies have
been carried out on the modulation of gene transcription by
non-coding RNAs. This book, written by a group of distinguished
scientists under the expert guidance of the editor Kevin V. Morris,
represents an important overview and summary of the field to date.
The thirteen chapters are organized into three sections: Non-coding
RNAs: Form, Function and Diversity; Non-coding RNAs: Gene
Regulation and Epigenetics; and Non-coding RNAs: Disease and
Therapeutics. This up-to-date volume is an essenti
Multifunctional Theranostic Nanomedicines in Cancer focuses on new
trends, applications, and the significance of novel multifunctional
nanotheranostics in cancer imaging for diagnosis and treatment.
Cancer nanotechnology offers new opportunities for cancer diagnosis
and treatment. Multifunctional nanoparticles harboring various
functions-including targeting, imaging, and therapy-have been
intensively studied with the goal of overcoming the limitations of
conventional cancer diagnosis and therapy. Thus theranostic
nanomedicines have emerged in recent years to provide an efficient
and safer alternative in cancer management. This book covers
polymer-based therapies, lipid-based therapies, inorganic
particle-based therapies, photo-related therapies, radiotherapies,
chemotherapies, and surgeries. Multifunctional Theranostic
Nanomedicines in Cancer offers an indispensable guide for
researchers in academia, industry, and clinical settings; it is
also ideal for postgraduate students; and formulation scientists
working on cancer.
Nitric Oxide in Plant Biology: An Ancient Molecule with Emerging
Roles is an extensive volume which provides a broad and detailed
overview of Nitric Oxide (NO) in plant biology. The book covers the
entirety of the crucial role NO plays in the plant lifecycle, from
the regulation of seed germination and growth to synthesis,
nitrogen fixation and stress response. Beginning with NO production
and NO homeostasis, Nitric Oxide in Plant Biology goes on to cover
a variety of NO roles, with a focus on NO signalling, crosstalk and
stress responses. Edited by leading experts in the field and
featuring the latest research from laboratories from across the
globe, it is a comprehensive resource of interest to students and
researchers working in plant physiology, agriculture,
biotechnology, and the pharmaceutical and food industries.
Brucella is a genus of Gram-negative, facultative, intracellular
bacteria that are highly pathogenic for a variety of mammals,
including humans. Recently the WHO cited brucellosis to be the
world's most widespread zoonosis. An important feature of the
pathogenicity of these organisms is their ability to survive and
replicate within the host macrophages. However the mechanism for
this is unclear. In addition, none of the classical bacterial
virulence factors found in other bacterial pathogens have been
found in the genomes of the forty Brucella species and biovars
analysed to date. Nevertheless the application of systems biology
approaches in recent years has transformed research, permitting
fascinating new insights into Brucella molecular biology and
genomics. Written by highly acclaimed Brucella scientists, this
book comprehensively reviews the most important advances in the
field. Opening chapters focus on genetic diversity within Brucella,
covering both classical and new species. Pa
Medical Epigenetics, Second Edition provides a comprehensive
analysis of epigenetics in health management, across a broad
spectrum of disease categories and specialties, and with a focus on
human systems, epigenetic diseases that affect these systems, and
evolving modes of epigenetic-based treatment. Here, more than 40
leading researchers examine how each human system is affected by
epigenetic maladies, offering an all-in-one resource on medical
epigenetics not only for those directly involved with health care,
but investigators in life sciences, biotech companies, graduate
students, and others who are interested in applied aspects of
epigenetics. Incorporating both diagnostic and prognostic
epigenetic approaches, this volume also fully supports the
application of epigenetics in precision medicine. This second
edition of Medical Epigenetics, a volume in the Translational
Epigenetics series, has been fully revised to address recent
advances in disease epigenetics and role of epigenetics in
precision medicine, with all-new chapters on skin cancer
epigenetics, network analysis in medical epigenetics, machine
learning in epigenetic diseases, and clinical trials of epigenetics
drugs.
Genomics of Rare Diseases: Understanding Disease Genetics Using
Genomic Approaches, a new volume in the Translational and Applied
Genomics series, offers readers a broad understanding of current
knowledge on rare diseases through a genomics lens. This clear
understanding of the latest molecular and genomic technologies used
to elucidate the molecular causes of more than 5,000 genetic
disorders brings readers closer to unraveling many more that remain
undefined and undiscovered. The challenges associated with
performing rare disease research are also discussed, as well as the
opportunities that the study of these disorders provides for
improving our understanding of disease architecture and
pathophysiology. Leading chapter authors in the field discuss
approaches such as karyotyping and genomic sequencing for the
better diagnosis and treatment of conditions including recessive
diseases, dominant and X-linked disorders, de novo mutations,
sporadic disorders and mosaicism.
|
|