Resident Stem Cells and Regenerative Therapy: Sources and Clinical Applications, Second Edition presents the main findings to date and the important factors to be considered when contemplating resident stem cells in regenerative therapies. Chapters on cardiac, brain, neural, liver, kidney, skeletal muscle, bone, pancreatic, skin and lung resident stem cells will assist in defining the level of success that has been achieved and the direction for the road ahead. With contributions from leading laboratories, open questions related to resident stem cells and regenerative therapies will also be presented for debate. In the last several decades, stem cells have greatly impacted the scientific and lay communities, providing huge advances in the treatment of devastating human diseases, including myocardial infarction, diabetes, muscular dystrophy, cystic fibrosis, cirrhosis, and osteoporosis. Alongside debates of induced pluripotent stem cells and embryonic stem cells has been the discovery of adult stem cells in many different tissues. While these organ resident or progenitor stem cells offer prospects to contribute to tissue regeneration, they also present challenges because of the complexity of organ structures.

This volume is the second in the series on 'Higher Plants', otherwise termed Phanerogam or Spermatophyte. The earlier volume, 1A, covered several taxa of Phanerogams and one of Bryophyte. A concurrent series (volume 2A, 2B and so on) cover the lower groups, represented by Algae, Fungi, Bryophytes and Lichens. Bryophyte, because of its importance in evolution of seed plants vis-a-vis higher groups, has been included in both volumes. The present volume includes articles dealing with certain fundamental issues of genomics as well as phylogeny and evolution of certain economic agricultural and medicinal crops. Of these, economic crops include coffee, coconut and papaya; medicinals cover Artemisia and Costus; fodder and agricultural crops include Phleum, Lolium and Triticale; horticultural species include Orchis and Allium and forest plant is represented by Populus species. In general, this volume contains discussions on molecular patters of basic angiosperms as well as genomics and phylogeny of different families covering several commercial, medicinal and agricultural crops.Those working on molecular genetics, evolution and phylogeny of flowering plants, including species of medicinal and agricultural value will find this book interesting.

Computational and high-throughput methods, such as genomics, proteomics, and transcriptomics, known collectively as -omics, have been used to study plant biology for well over a decade now. As these technologies mature, plant and crop scientists have started using these methods to improve crop varieties. Omics in Plant Breeding provides a timely introduction to key omicsbased methods and their application in plant breeding. Omics in Plant Breeding is a practical and accessible overview of specific omics-based methods ranging from metabolomics to phenomics. Covering a single methodology within each chapter, this book provides thorough coverage that ensures a strong understanding of each methodology both in its application to, and improvement of, plant breeding. Accessible to advanced students, researchers, and professionals, Omics in Plant Breeding will be an essential entry point into this innovative and exciting field. A valuable overview of high-throughput, genomics-based technologies and their applications to plant breeding Each chapter explores a single methodology, allowing for detailed and thorough coverage Coverage ranges from well-established methodologies, such as genomics and proteomics, to emerging technologies, including phenomics and physionomics Aluizio Borem is a Professor of Plant Breeding at the University of Vicosa in Brazil. Roberto Fritsche-Neto is a Professor of Genetics and Plant Breeding at the University of Sao Paulo in Brazil.

Emerging Plant Growth Regulators in Agriculture: Roles in Stress Tolerance presents current PGR discoveries and advances for agricultural applications, providing a comprehensive reference for those seeking to apply these tools for improved plant health and crop yield. As demand for agricultural crops and improved nutritional requirement continue to escalate in response to increasing population, plant researchers have focused on identifying scientific approaches to minimize the negative impacts of climate change on agriculture crops. Among the various applied approaches, the application of plant growth regulators (PGRs) have gained significant attention for their ability to enhance stress tolerance mechanisms. This book was developed to provide foundational and emerging information to advance the discovery of novel, cost-competitive, specific and effective PGRs for applications in agriculture.

The first chapter details the different techniques of molecular markers, emphasizing genetic aspects, because these determine the type of use one can put it to. The construction of genetic linkage maps is the subject of the second chapter, where the advantages and disadvantages of the most common mapping populations are specified. The particular case of mapping of major genes, especially for the purpose of positional cloning, is addressed in the third chapter. Detection and applications of QTLs controlling the expression of quantitative traits are presented in the fourth chapter, which also tackles the complex question of their identification. The fifth chapter underscores the major contribution of molecular markers in the analysis of the structure and evolution of natural populations. Finally, the advantages of markers in selection, for studies of diversity and in the context of marker-assisted selection, are discussed in the last chapter. The authors have attempted to highlight the principles of markers, an

'It's all in the genes'. Is this true, and if so, what is all in the genes? Genes: A Philosophical Inquiry is a crystal clear and highly informative guide to a debate none of us can afford to ignore.
Beginning with a much-needed overview of the relationship between science and technology, Gordon Graham lucidly explains and assesses the most important and controversial aspects of the genes debate: Darwinian theory and its critics, the idea of the 'selfish' gene, evolutionary psychology, memes, genetic screening and modification, including the risks of cloning and 'designer' babies.
He considers areas often left out of the genes debate, such as the environmental risks of genetic engineering and how we should think about genes in the wider context of debates on science, knowledge and religion. Gordon Graham asks whether genetic engineering might be introducing God back into the debate and whether the risks of a brave new genetic world outweigh the potential benefits.
Essential reading for anyone interested in science, technology, and philosophy, Genes: A Philosophical Inquiry is ideal for those wanting to find out more about the ethical implications of genetics and the future of biotechnology.

The discovery in the 1920s of a huge cache of fossils in the Gobi Desert fuelled a mania for dinosaurs that continues to the present. But the original goal of the expedition was to search for the origins of man. Henry Fairfield Osborn (1857-1935), director of the American Museum of Natural History, stood at the forefront of the debate over human evolution and the expedition aimed to prove his theory of human origins. Osborn rejected the idea of primate ancestry and constructed a non-Darwinian theory that the evolution of man was the long adventurous story of individuals and groups exerting personal will-power and inborn characteristics to achieve both biological and spiritual success. It is an idea that still echoes today. Study of Osborn's thinking, however, has been obscured by the perception that racism influenced his theories. Brian Regal paints a different and more textured picture in this book - he shows that Osborn's views on race, like his political ideas, were motivated by his science, itself grounded in religious doctrine. His belief in the Central Asian origins of man, his role as an activist for eugenic reform and immigration controls, his support for Nordicism, his place in the 'New' versus 'Old' biology debate, his role in the Christian Fundamentalist controversy, the Scopes Monkey trial, and finally his construction of the 'Dawn Man' hypothesis - all stemmed from his desire to support his human evolution theory, and point the way to salvation. This biography charts Osborn's intellectual development, from its roots in the eclectic Christianity of his mother, through his student days with Arnold Guyot, James McCosh, and T.H. Huxley, to his mature work at the American Museum. It examines his trials and tribulations, friendships and conflicts, and the world in which he lived: all contributed to the construction of his theory. It is the dramatic story of a man holding onto ideas that for him represented the very meaning of life itself.

QTL Mapping in Crop Improvement: Present Progress and Future Perspectives presents advancements in QTL breeding for biotic and abiotic stresses and nutritional improvement in a range of crop plants. The book presents a roadmap for future breeding for resilience to various stresses and improvement in nutritional quality. Crops such as rice, wheat, maize, soybeans, common bean, and pigeon pea are the major staple crops consumed globally, hence fulfilling the nutritional requirements of global populations, particularly in the under-developed world, is extremely important. Sections cover the challenges facing maximized production of these crops, including diseases, insect damage, drought, heat, salinity and mineral toxicity. Covering globally important crops including maize, wheat, rice, barley, soybean, common bean and pigeon pea, this book will be an important reference for those working in agriculture and crop improvement.

ONE OF AMAZON'S TOP 100 BOOKS OF 2014 Neanderthal Man tells the story of geneticist Svante Paabo's mission to answer this question: what can we learn from the genomes of our closest evolutionary relatives? Beginning with the study of DNA in Egyptian mummies in the early 1980s and culminating in the sequencing of the Neanderthal genome in 2010, Neanderthal Man describes the events, intrigues, failures, and triumphs of these scientifically rich years through the lens of the pioneer and inventor of the field of ancient DNA. We learn that Neanderthal genes offer a unique window into the lives of our hominid relatives and may hold the key to unlocking the mystery of why humans survived while Neanderthals went extinct. Paabo's findings have not only redrawn our family tree, but recast the fundamentals of human history,the biological beginnings of fully modern Homo sapiens , the direct ancestors of all people alive today.

Learn how your DNA can empower you to make life choices that lead to a happier, healthier life The personalized medicine wave is here. In this book, biotechnology entrepreneur and CEO of The DNA Company Kashif Khan offers an action plan to help you live your best life. It starts by understanding your genetic makeup. The DNA Way is a preventative guide to various health issues and their link to an individual’s DNA. In it, readers will discover what the DNA Company experts have learned about chronic illness and genetic predispositions, based on years of in-depth genetic analysis of the DNA results of more than 7,000 people. Topics that will be addressed include mood and behavior, energy, diet and nutrition, weight management, sleep, and more. The book will delve into Kashif’s personal journey of overcoming his own genetic legacy and health challenges—using his own DNA results as a case study—and in navigating that journey, how he came to develop a company whose aim is to elevate humanity. It also outlines recommendations—including what foods to eat, how to exercise, and where and how to work—that have helped him prevent or reverse illness, slow down the aging process, and optimize his performance. Learn how to access your human instruction manual—the DNA way.

The "Encyclopedia" includes 125 entries, beginning with the origins of genetics including historical background on the work of Gregor Mendel and Charles Darwin, and progressing to the structure of DNA and modern theories such as selfish genes.
All branches of genetics are covered, including the genetics of bacteria, viruses, insects, animals and plants, as well as humans. Important topical issues such as the human genome project, bioethics, the law and genetics, genetic disorders, GM crops, and the use of transgenic animals for food and pharmaceutical products are fully surveyed. A section on techniques and biotechnology includes modern methods of analysis, from DNA fingerprinting to the new science of bioinformatics.
The articles, all written by specialists, are largely non-mathematical and progress from general concepts to deeper understanding. Each essay is fully referenced, with suggestions for further reading. The text is supplemented by extensive illustrations, tables and a color plate section.
The "Encyclopedia of Genetics" will be a valuable companion for all those working or studying in the various fields of genetical research, and a fascinating reference for all readers with a basic background in biology. Also includes color inserts.

Advances in genetic technology in general and medical genetics in particular will enable us to intervene in the process of human biological development which extends from zygotes and embryos to people. This will allow us to control to a great extent the identities and the length and quality of the lives of people who already exist, as well as those we bring into existence in the near and distant future. "Genes and Future People" explores two general philosophical questions, one metaphysical, the other moral: (1) How do genes, and different forms of genetic intervention (gene therapy, genetic enhancement, presymptomatic genetic testing of adults, genetic testing of preimplantation embryos), affect the identities of the people who already exist and those we bring into existence? and (2) How do these interventions benefit or harm the people we cause to exist in the near future and those who will exist in the distant future by satisfying or defeating their interest in having reasonably long and disease-free lives?"Genes and Future People" begins by explaining the connection between genes and disease, placing genetic within a framework of evolutionary biology. It then discusses such topics as how genes and genetic intervention influence personal identity, what genetic testing of individuals and the knowledge resulting from it entails about responsibility to others who may be at risk, as well as how gene therapy and genetic enhancement can affect the identities of people and benefit or harm them. Furthermore, it discusses various moral aspects of cloning human beings and body parts. Finally, it explores the metaphysical and moral implications of genetic manipulation of the mechanisms of aging to extend the human life span.The aim "Genes and Future People" is to move philosophers, bioethicists, and readers in general to reflect on the extent to which genes determine whether we are healthy or diseased, our identities as persons, the quality of our lives, and our moral obligations to future generations of people.

Radiation-Processed Polysaccharides: Emerging Roles in Agriculture is the first book to focus exclusively on this emerging and important option for reducing the overuse and negative impact of agrochemicals in agriculture. Among practices being developed for effective and eco-friendly plant growth regulators in crop production, using radiation-processed polysaccharides (RPPs) is a promising technique. Comprised of chapters from diverse areas of plant science, including agriculture, agronomy, biotechnology, nanotechnology, molecular biology, and radiation agriculture, this book provides insights into the practical application of RPPs and inspires further research toward sustainable and efficient agricultural production. Polysaccharides (sodium alginate, carrageenan, chitosan and others) in their depolymerized state are increasingly important to agriculture based on their unique biological properties, biocompatibility, biodegradability and non-toxicity. Understanding the impact of RPPs on the plant phenotype, translocation of nutrients from source to sink, signal processing, and crosstalk helps improve the applicability of RPPs and sustainable agricultural yield.

Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth.

Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging. This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability.

Now updated for its second edition, Population Genetics is the classic, accessible introduction to the concepts of population genetics. Combining traditional conceptual approaches with classical hypotheses and debates, the book equips students to understand a wide array of empirical studies that are based on the first principles of population genetics. Featuring a highly accessible introduction to coalescent theory, as well as covering the major conceptual advances in population genetics of the last two decades, the second edition now also includes end of chapter problem sets and revised coverage of recombination in the coalescent model, metapopulation extinction and recolonization, and the fixation index.

Experts from The Jackson Laboratory and around the world provide practical advice on everything from how to establish a colony to where to go for specific mutations. Systematic Approach to Evaluation of Mouse Mutations includes information on medical photography, grafting procedures, how to map the genes and evaluate the special biological characteristics of the mice.

Genome Editing in Plants: Principles and Applications addresses the information of genome editing starting from principles and historical aspects to the latest advancements in the field. As genome-editing technology has emerged as promising and cutting edge, researchers around the world have started producing original research outputs, which have significantly improved our current understanding and potential of this technology. The initial chapters of this book describe different genome-editing tools as well as their principles and applications. Other chapters are dedicated to the present status and future applications of genome-editing techniques in various crop improvement programmes. Some of the advanced applications of CRISPR/Cas tools, such as base editing and RNA detection, along with regulatory aspects of genome-edited crops are described in detail. This book serves as a valuable resource to researchers in the field of crop improvement; graduate and postgraduate students engaged in plant molecular biology and biotechnology; academicians; and policy makers. Key Features: Addresses topics associated with historical development and principles of genome-editing technology Addresses basic mechanisms operating under each genome-editing technology Addresses its application in plants to design crops as per the current and future demands Addresses the regulatory mechanisms of genome-edited crops

This innovative reference explores a wide selection of topics associated with aging, providing a solid understanding of the significance and molecular basis of the aging process and charting the course of future research in the area. Stresses the interplay of mitochondria, mitochondrial DNA, oxidants, and antioxidants! Featuring the research of over 55 experts in the area, Understanding the Process of Aging -covers the functions of nitric oxide and peroxynitrite in mitochondria -integrates several views on the role of mitochondria in the development of apoptosis -gives a quantitative analysis of mutations of mitochondrial DNA during human aging -highlights mitochondrial free radical production -introduces new roles of ubiquinone in mitochondrial functions -offers new antioxidant-based complementary therapeutic strategies -details aspects of intact cells and whole organisms in health and disease -and more! Featuring over 1800 references, tables, drawings, and photographs, Understanding the Process of Aging benefits nutritionists and dieticians, geriatricians, cell and molecular biologists, chemists and biochemists, pharmacologists, biotechnologists, neurologists, cardiologists, oncologists, dermatologists, and graduate and medical school students in these disciplines.

'I loved reading this book, gained further insight into the complexity of human life, and am inspried by the depth of thought, care and experience the author brings to her work. The book is practical, easy to read, rovesfreely between stories and concepts. The Ancestor Syndrome will appeal to anyne who values therapeutic intervention.' - ANZPA Journal

The title of this book derives from C. Wright Mills' classic The Sociological Imagination (Penguin, 1970), in which he sees the essential project of social science as the use of the imagination to 'grasp history and biography and the relations between the two in society'. This enables the social scientist to 'range from the most impersonal and remote transformations to the most intimate features of the human self'. Another of Mills' concerns was the relationship between 'the personal troubles of the milieu' and 'the public issues of social structure' and these are most acutely illustrated in human genetics, the most personal of the new technologies. The chapters in this volume address these issues through discussions of choice and informed decision-making, risks and hazards, the economic and political organization of new technology, and the public as well as the scientist's understanding of science. The methods used range from detailed ethnographies, through deconstruction's of text and action, to surveys and interviews.

The analysis and interpretation of data is fundamental to the subject of genetics and forms a compulsory part of the undergraduate genetics curriculum. Indeed, the key skills that a genetics student requires are an ability to design and understand experimental strategies and to use problem-solving skills to interpret experimental results and data. Genetics? No Problem! provides students with a graded set of problems that aim to enthuse, challenge and entertain the reader. The book is divided into three sections introductory; intermediate and advanced each with 10 problems. For first level students there will be short genetics problems embedded in a wide range of scenarios, such as murder mysteries. As the book progresses, the stories will get longer and the science will get progressively more complex to challenge final year students and enable the reader to identify genetic disease in obscure organisms as well as designing and testing treatments and cures. Genetics? No Problem!: * Takes a unique, innovative approach that provides students with a set of graded problems designed to develop both their skills, and their ability to tackle problems with confidence * Includes problems embedded in a narrative, written in an interesting, informative and entertaining style by an Author with a proven track record in teaching, research and communication * Is well illustrated in full colour throughout. The book will prove invaluable to all students of genetics across a range of disciplines needing to get to grips with the analysis and interpretation of data that is fundamental to the subject.

This book documents and critically analyses the photographs that helped to strengthen as well as bring down the eugenics movement. Using a large body of racial-type images and a variety of historical and archival sources, and concentrating mainly on developments in Britain, the USA and Nazi Germany, this book explains how photography, as the most powerful visual medium of the late nineteenth and early twentieth centuries, was vital to the eugenics movement's success -- not only did it allow eugenicists to identify the people with superior and inferior hereditary traits, but it helped publicise and lend scientific authority to eugenicists' racial theories. The author argues for a strong connection between the racial-type photographs that eugenicists created and the photographic images produced by nineteenth-century anthropologists and prison authorities, and how the photographic works of contemporary liberal anthropologists played a significant role in the eugenics movement's downfall. Besides adding to our knowledge of photography's crucial role in helping to authorise and implement some of the most controversial social policies of modem times, this book makes a major contribution to our understanding of the history of racism. The book looks at eugenics from the standpoint of its most significant cultural data -- racial-type photography, investigating the techniques, media forms, and styles of photography used by eugenicists, and relating these to their racial theories and their social policies and goals. It demonstrates how the visual archive was crucially constitutive of eugenic racial science because it helped make many of its concepts appear both intuitive as well as scientifically legitimate.

Bittersweet Destiny combines discourse on the evolution of human behavior with a philosophical perspective. It explores evolutionary theory aimed at determining human behavior. Del Thiessen presents this material against the broad background of everyday life, allowing the reader to see the theory of evolution as it has shaped his or her own behavior. However, he points out that when evolutionary theory is aimed at human behavior, the critics object, and controversy results.

Thiessen argues that nothing in our lives makes sense unless we look at it through a biological lens. We can thereby understand our origin, our affiliation with all animals and plants, and our cultural destination. However, we can also discover a dark side to our destiny--our favoritism to those who share our own genes, our ability to deceive, and our capacity for abuse, rape, and murder. Good, bad, and indifferent, we serve the replication of our DNA. Critics extrapolate evolutionary theory to a wide range of animal species, and even human morphology and physiology, but when the same perspective is applied to human behavior there is strong dissent. What these critics fear, according to Thiessen, is that accepting evolutionary notions about human behavior strikes at the heart of free will, self-determination, and social equality.

Bittersweet Destiny describes the heroic efforts of naturalists Charles Darwin and Alfred Wallace to unlock the secrets of evolution. It continues with a vivid description of our fossil history and our chance beginnings. From there the story implicates disease processes in evolution, highlights our rational and irrational nature, focuses on those characteristics of brain evolution and language that make us distinctive, and illustrates our most basic survival and reproductive mechanisms. Thiessen warns the reader that things are as they are no matter what we might wish; we ignore facts and controversy at our own risk. This book will be significant to anthropologists, psychologists, biologists, and sociologists.

Advances in Cancer Research, Volume 150, the latest release in this ongoing series, covers the relationship(s) between autophagy and senescence, how they are defined, and the influence of these cellular responses on tumor dormancy and disease recurrence. Specific sections in this new release include Autophagy and senescence, converging roles in pathophysiology, Cellular senescence and tumor promotion: role of the unfolded protein response, autophagy and senescence in cancer stem cells, Targeting the stress support network regulated by autophagy and senescence for cancer treatment, Autophagy and PTEN in DNA damage-induced senescence, mTOR as a senescence manipulation target: A forked road, and more.