DNA Repair and Replication brings together contributions from active researchers. The first part of this book covers most aspects of the DNA damage response, emphasizing the relationship to replication stress. The second part concentrates on the relevance of this to human disease, with particular focus on both the causes and treatments which make use of DNA Damage Repair (DDR) pathways. Key Selling Features: Chapters written by leading researchers Includes description of replication processes, causes of damage, and methods of repair

Standing on the Shoulders of Darwin and Mendel: Early Views of Inheritance explores early theories about the mechanisms of inheritance. Beginning with Charles Darwin's now rejected Gemmule hypothesis, the book documents the reception of Gregor Mendel's work on peas and follows the work of early 20th century scholars. The research of Francis Galton, a cousin of Darwin, and the friction it caused between these two are a part of longer story of the development of genetics and an understanding of how offspring inherit the characteristics of their parents. Bateson, Garrod, de Vries, Tschermak and others are all characters in a scientific story of discovery, acrimony, cooperation and revelation.

Let's face it, say Barash and Lipton: Males and females, boys and girls, men and women are different. To be sure, these differences are often heightened by distinctions in learning, cultural tradition, and social expectation, but underpinning them all is a fundamental difference that derives from biology. Throughout the natural world, males are those creatures that make sperm; females make eggs. The oft-noticed "gender gap" derives, in turn, from this "gamete gap." In "Gender Gap," Barash and Lipton (husband and wife, professor and physician, biologist and psychiatrist) explain the evolutionary aspects of male-female differences.

After describing the theory underlying the evolutionary explanation of male-female differences-in accessible, lay-person's language-they show how it applies to specific examples of animal behavior. Then, they demonstrate comparable male-female differences in the behavior of human beings cross-culturally, as well as within the United States. Barash and Lipton apply this approach to male-female differences in sexual inclinations, propensities for violence, parenting styles, and childhood experiences. They invoke much work within the traditional social sciences, such as psychology, anthropology, and sociology, which have typically ignored biological factors in the past.

Part of the highly successful revolution in scientific thought has been the recognition that evolutionary insights can illuminate behavior, no less than anatomy and physiology. This new discipline, sometimes called "sociobiology" or "evolutionary psychology," promises to help us make sense of ourselves and of our most significant others, shedding new light on what it means to be male or female. Now available in paperback with a new introduction by the authors, this accessible volume integrates work from a variety of fields, applying a new paradigm to research on gender differences.

Access to genetic resources and Benefit Sharing (ABS) has been promoted under the Convention on Biological Diversity, with the aim of combining biodiversity conservation goals with economic development. However, as this book shows, since its inception in 1992, implementation has encountered multiple challenges and obstacles. This is particularly so in the marine environment, where interest in genetic resources for pharmaceuticals and nutrients has increased. This is partly because of the lack of clarity of terminology, but also because of the terms of the comprehensive law of the sea (UNCLOS) and transboundary issues of delineating ownership of marine resources. The author explains and compares relevant provisions and concepts under ABS and the law of the sea taking access, benefit sharing, monitoring, compliance, and dispute settlement into consideration. He also provides an overview of the implementation status of ABS-relevant measures in user states and identifies successful ABS transactions. A key unique feature of the book is to illustrate how biological databases can serve as the central scientific infrastructure to implement the global multilateral benefit sharing mechanism, proposed by the Nagoya Protocol. The research for this book was supported by both the Bremen International Graduate School for Marine Sciences (GLOMAR) and the International Research Training Group INTERCOAST - Integrated Coastal Zone and Shelf-Sea Research.

In today's world, we are witnessing simultaneous breakthroughs in reproductive technologies, genomics, and molecular biology. Advances in molecular genetic technology and understanding of the bovine genome have led to the development of tools that can be used to enhance profitability on cow-calf enterprises. Factors Affecting Calf Crop: Biotechnology of Reproduction provides a detailed compilation of current and forthcoming technology for managing reproduction in cattle.

The book discusses topics such as: approved techniques for controlling the estrous cycle in cattle; managing follicular growth with progesterone, estrogens, and prostaglandins; freezing, thawing, and transfer of cattle embryos; application of embryo transfer to the beef cattle industry; embryo transfer in topically adapted cattle; new factors affecting bull fertility; embryo collection and utilization technology, in vitro fertilization, somatic cell cloning, and genetic technologies; uses of real-time ultrasound; and sexed semen.

Over 25 leading animal scientists have combined their expertise to produce the first single-source reference that covers successful reproductive techniques that will, most likely, be the wave of the future. Expansive in scope, the book addresses current biotechnologies as they impact the production of beef cattle. Written at a level to appeal to the researcher, commercial producer, or student, Factors Affecting Calf Crop: Biotechnology of Reproduction presents you with a wealth of technologies applicable to animal agriculture.

First published in 1923, this book explores the impact on development that heredity and environment has on children. Chaplin argues that too much reliance is placed on education and in fact parents, physicians and teachers should equally be taking into consideration the physical and mental constitution of the child, which could be linked to hereditary and environmental factors. In conjunction with the moral, spiritual and intellectual predispositions that the child may have, Chaplin argues the pros of eugenics (in the perspective of the early 20th century) and equally the importance of euthenics for future prosperity of generations to come.

The rise of the multi-billion dollar ancestry testing industry points to one immutable truth about us as human beings: we want to know where we come from and who our ancestors were. John H. Relethford and Deborah A. Bolnick explore this topic and many more in this second edition of Reflections of Our Past. Where did modern humans come from and how important are the biological differences among us? Are we descended from Neandertals? How should we understand the connections between genetic ancestry, race, and identity? Were Native Americans the first to inhabit the Americas? Can we see evidence of the Viking invasions of Ireland a millennium ago even in the Irish of today? Through engaging examination of issues such as these, and using non-technical language, Reflections of Our Past shows how anthropologists use genetic information to suggest answers to fundamental questions about human history. By looking at genetic variation in the world today and in the past, we can reconstruct the recent and remote events and processes that have created the variation we see, providing a fascinating reflection of our genetic past.

Genetic Steroid Disorders, Second Edition targets adult and pediatric endocrinologists, clinical geneticists, genetic counselors, reproductive endocrinologists, neonatologists, urologists, and psychoendocrinologists. It is designed to assist these specialists in the diagnosis and treatment of steroid disorders. This revision includes a new chapter on "Gonadotropins, Obesity and Bone" and new research on non-invasive prenatal diagnosis with cell-free DNA. Chapters are thoroughly updated covering steroid disorders, the genetic bases for the disorder and case presentations, This definitive reference belongs in every medical library!

Volume I of this book provides a comprehensive discussion of the factors involved in regulation of the cell cycle, the general biological properties of growth factors, and the receptor and postreceptor mechanisms of action of these signaling agents. It evaluates the possible role of growth factors in the regulation of proto-oncogene and tumor suppressor gene expression, and the development of neoplastic processes is discussed in detail.

In Situ hybridization allows the visualization of specific DNA/RNA sequences in individual cells in tissue sections, single cells, or chromosome preparations, and is an especially important method for studying DNA and RNA in heterogeneous cell populations. This book delves into in situ hybridization methods through the use of light microscopy used by molecular biologists, pathologists, geneticists, and biochemists. It will also appeal to research scientists who are interested in visualizing methods for nucleic acids and proteins. The book features a two-column layout for protocols/principles, simplifies the techniques and offers many schemes and tables to help the reader choose the best procedure.

Transcription factors are important in regulating gene expression, and their analysis is of paramount interest to molecular biologists studying this area. This book looks at the basic machinery of the cell involved in transcription in eukaryotes and factors that control transcription in eukaryotic cells. It examines the regulatory systems that modulate gene expression in all cells, a s well as the more specialized systems that regulate localized gene expression throughout the mammalian organism.

Transcription Factors updates classical knowledge with recent advances to provide a full and comprehensive coverage of the field for postgraduates and researchers in molecular biology involved in the study of gene regulation.

Economics is traditionally taken to be the social science concerned with the production, consumption, exchange, and distribution of wealth and commodities. Economists carefully track the comings and goings of the human household, whether written small (microeconomics) or large (macroeconomics) and attempt to predict future patterns under different situations. However, in constructing their models of economic behavior, economists often lose sight of the actual characteristics and motivations of their human subjects. In consequence, they have found the goal of an explanatory and predictive science to be elusive. Economics as an Evolutionary Science reorients economics toward a more direct appreciation of human nature, with an emphasis on what we have learned from recent advances in evolutionary science. The authors integrate economics and evolution to produce a social science that is rigorous, internally coherent, testable, and consistent with the natural sciences. The authors suggest an expanded definition of "fitness," as in Darwin's survival of the fittest, emphasizing not only the importance of reproduction and the quality of offspring, but also the unique ability of humans to provide material wealth to their children. The book offers a coherent explanation for the recent decline in fertility, which is shown to be consistent with the evolutionary goal of maximizing genetic success. In addition, the authors demonstrate the relevance to economics of several core concepts derived from biologists, including the genetics of parent-offspring conflict, inclusive fitness theory, and the phenomena of R-selection and K-selection. The keystone of their presentation is a cogent critique of the traditional concept of "utility." As the authors demonstrate, the concept can be modified to reflect the fundamental evolutionary principle whereby living things-including human beings-have been selected to behave in a manner that maximizes their genetic representation in future generations. Despite the extraordinary interest in applying evolutionary biology to other disciplines, Economics as an Evolutionary Science marks the first major attempt at a synthesis of biology and economics. Scholarly yet accessible, this volume offers unique and original perspectives on an entire discipline. Arthur E. Gandolfi is vice president and senior portfolio manager for Citicorp Bank Cards Treasury. He is co-author of The International Transmission of Inflation. Anna Sachko Gandolfi is professor of economics, finance, and management at Manhattanville College at Purchase, NY. David P. Barash is professor of psychology and zoology at the University of Washington where he has taught since 1973. He is the author of twenty books and more than 170 technical articles.

When a pharmaceutical company decides to build a Quality System, it has to face the fact that there aren't any guideline that define exactly how such a system has to be built. With terms such as quality system, quality assurance, and quality management used interchangeably, even defining the system's objectives is a problem. This book provides a practical guide to building a quality system. Beginning with explanations of key terms and concepts, it covers ISO 9000 and GMP and how to combine them, and includes a matrix showing their similarities and differences. Implementation reviews illustrate how Quality (Management) Systems have been installed successfully in pharmaceutical companies. Also covered are the individual components of a Quality System; auditing, validation, and supplier qualification systems; and Hazard Analysis Critical Control Points (HACCP).

Although the basic statistical theory behind modern genetics is not very difficult, most statistical genetics papers are not easy to read for beginners in the field, and formulae quickly become very tedious to fit a particular area of application.
Introduction to Statistical Methods in Modern Genetics distinguishes between the necessary and unnecessary complexity in a presentation designed for graduate-level statistics students. The author keeps derivations simple, but does so without losing the mathematical details. He also provides the required background in modern genetics for those looking forward to entering this arena. Along with some of the statistical tools important in genetics applications, students will learn:
How a gene is found
How scientists have separated the genetic and environmental aspects of a person's intelligence
How genetics are used in agriculture to improve crops and domestic animals
What a DNA fingerprint is and why there are controversies about it
Although the author assumes students have a foundation in basic statistics, an appendix provides the necessary background beyond the elementary, including multinomial distributions, inference on frequency tables, and discriminant analysis. With clear explanations, a multitude of figures, and exercise sets in each chapter, this text forms an outstanding entr?e into the rapidly expanding world of genetic data analysis.

Learn how your DNA can empower you to make life choices that lead to a happier, healthier life The personalized medicine wave is here. In this book, biotechnology entrepreneur and CEO of The DNA Company Kashif Khan offers an action plan to help you live your best life. It starts by understanding your genetic makeup. The DNA Way is a preventative guide to various health issues and their link to an individual’s DNA. In it, readers will discover what the DNA Company experts have learned about chronic illness and genetic predispositions, based on years of in-depth genetic analysis of the DNA results of more than 7,000 people. Topics that will be addressed include mood and behavior, energy, diet and nutrition, weight management, sleep, and more. The book will delve into Kashif’s personal journey of overcoming his own genetic legacy and health challenges—using his own DNA results as a case study—and in navigating that journey, how he came to develop a company whose aim is to elevate humanity. It also outlines recommendations—including what foods to eat, how to exercise, and where and how to work—that have helped him prevent or reverse illness, slow down the aging process, and optimize his performance. Learn how to access your human instruction manual—the DNA way.

Utilizing the flood of new information derived from the Human Genome Project and corresponding efforts to elucidate the mouse genome, Genetic Influences on Neural and Behavioral Functions provides a scholarly catalog, organized logically, of relations between the expression of specific genes, nerve cell biology and behavior, normal and abnormal, in animals AND humans.
Sample topics include genes in relation to schiziphrenia, panic disorder, epilepsy, alcoholism, sleep, eating disorders, and more.

Molecular biology and genetics techniques now dominate viral research in attempts to cure diseases such as AIDS. Viral Genome Methods is a practical guide to the newest molecular techniques, providing step-by-step protocols to be used in the laboratory. Recognized authorities and pioneers in viral research pass on their expertise to you.

The field of materials science and technology has undergone revolutionary advances due to the development of novel analytical tools, functional materials, and multidisciplinary approaches to engineering. Additionally, theoretical predictions combined with increasingly improved models and computational capabilities are making impressive contributions to the progress of materials science and technology. In particular, the materials science of DNA has emerged as a vital area of research and is expected to immensely broaden the horizon of material science and nanotechnology in this century. Materials Science of DNA highlights the most important subjects and perspectives in the field, with the aim of stimulating the interdisciplinary community and bringing this intensively interesting, emerging field of molecular-scale materials science to maturation. The editors have not only been involved in the research of materials science of DNA for the past decade, but also lead the series of International Biotronics Workshops supported by the US Air Force Research Laboratory. Biotechnology and DNA-based biopolymers are not only applicable for genomic sequencing and clinical diagnosis and treatment, but can also have a major impact on nonbiotech applications-such as electronics and photonics- opening up a whole new field for bioengineering. New concepts and insights gained from DNA research are expected to prove genuinely useful in a variety of devices in nano, micro, and macro dimensions in the future. Where silicon has been the building block of inorganic electronics and photonics, DNA holds promise to become the building block for organic electronics and photonics.

This first volume in the series provides a detailed treatment in ecotoxicology and stresses why genetics is important in understanding if and how chemical contaminants affect populations. Written by an array of international contributors from various fields covering mammals, invertebrates, fish, plants, as well as molecular ecotoxicology, this book considers both ecological/evolutionary consequences and practical implications of the interplay between chemical toxicants and the genetic population.
In broadening the understanding of ecological response, this resource ranges from molecular to classical genetics, from plant to animal, from asexual to sexual, touching on some fundamental issues of evolutionary biology. In addition, gaps in our present understanding of genetic and ecotoxicological processes and future research directions have been identified.

Advances in sequencing technology have allowed scientists to study the human genome in greater depth and on a larger scale than ever before - as many as hundreds of millions of short reads in the course of a few days. But what are the best ways to deal with this flood of data? Algorithms for Next-Generation Sequencing is an invaluable tool for students and researchers in bioinformatics and computational biology, biologists seeking to process and manage the data generated by next-generation sequencing, and as a textbook or a self-study resource. In addition to offering an in-depth description of the algorithms for processing sequencing data, it also presents useful case studies describing the applications of this technology.

First published in 1998. This book is targeted at the beginner who has little or no knowledge of the principles or practice of hybridization. This text concentrates on solution and filter hybridization with a final chapter on current developments which includes DNA chips and advances in probe design.

The book is primarily concerned with DNA fingerprinting and DNA profiling in the context of forensic medicine and kinship testing. It concentrates on methods of determining the degree of relatedness of members of the same species, focusing on humans and occasionally glancing at other species.

An important new collection of clinical and preclinical reports on genetic therapy, this book describes illustrative examples of diseases in which gene-based interventions are presently plausible, and presents case studies of current research using both synthetic oligonucleotides and biological vectors. Combining the insights of over 50 contributors, Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors -furnishes a historical overview of genetic therapy -highlights official Food and Drug Administration positions on the preparation of oligonucleotides and vectors -offers practical models of agent preparation, animal testing, pharmacokinetics, toxicology, and clinical trials -discusses both synthetic DNA and biological vector approaches to cancer, viral, and cardiological indications -illustrates for new practitioners how each stage of genetic therapy is developed -details genetic treatment of leukemia; lymphoma; cancer of the brain, breast, colon, kidney, and lung; melanoma; HIV; and coronary restenosis -includes examples of antisense, ribozyme, tumor suppressor, immunostimulation, and gene replacement therapy -and addresses questions of preparation, delivery, toxicity, mechanism, and specificity.

This volume comprises papers presented at a conference on genomics. The papers discuss whether the availability of genome sequence information for humans and other organisms will yield commercial opportunities and if so, how companies could make use of this information. Examples of commercial applications of genomics in medicine and agriculture are provided. This book is aimed at molecular and clinical geneticists, plant geneticists and molecular biologists.

What should individuals and society do when genetic screening becomes widely available and with its impact on current and future generations still uncertain? How can our education systems around the world respond to these developments? Reproductive and genetic technologies (RGTs) are increasingly controversial and political. We are entering an era where we can design future humans, firstly, by genetic screening of "undesirable" traits or indeed embryos, but perhaps later by more radical genetic engineering. This has a profound effect on what we see as normal, acceptable and responsible. This book argues that these urgent and biopolitical issues should be central to how biology is taught as a subject. Debate about life itself has always been at the forefront of connected molecular, genetic and social/personal identity levels, and each of these levels requires processes of communication and debate, what Anthony Giddens called in passing life politics. In this book Padraig Murphy opens the term up, with examples from field research in schools, student responses to educational films exploring the future of RGTs, and science studies of strategic biotechnology and the lab practices of genetic screening. Life political debate is thoroughly examined and is identified as a way of connecting mainstream education of biology with future generations. Biotechnology, Education and Life Politics will appeal to post-graduates and academics involved with science education, science communication, communication studies and the sociology of education.