"Advances in Cancer Research" provides invaluable information on the exciting and fast-moving field of cancer research. This thematic volume looks at "Histone Deacetylase Inhibitors as Cancer Therapeutics."
Provides invaluable information on the exciting and fast-moving field of cancer researchThis thematic volume looks at "Histone Deacetylase Inhibitors as Cancer Therapeutics"Outstanding and original reviews

Focusing on the systems biology of bacteria and microorganisms, the 39th volume of "Methods in Microbiology"investigates the interface between molecular biology, bioinformatics, and modelling" "and predicting behavior. This cutting-edge research area is of extreme importance to the field and is developing quickly.
Written by research experts in the fieldProvides a guide for lab scientists, researchers, and studentsFocuses on up-to-date research methods"

Described as the earliest, simplest life forms, with unlimited metabolic versatility, bacteria are ideally suited to answer some very fundamental questions on life and its processes. They have been employed in almost all fields of biological studies, including Genetics. The whole edifice of science of Genetics centers around three processes: the generation, expression, and transmission of biological variation, and bacteria offer immediate advantages in studying all the three aspects of heredity. Being haploid and structurally simple, it becomes easy to isolate mutations of various kinds and relate them to a function. The availability of such mutants and their detailed genetic and biochemical analyses lead to a gamut of information on gene expression and its regulation. While studying the transmission of biological variation, it is clear that unlike their eukaryotic counterpart, a more genetic approach needs to be employed. Transmission of genetic information in most eukaryotic organisms rests on sexual reproduction that allows the generation of genetically variable offspring through the process of gene recombination. Even though bacteria show an apparent preference for asexual reproduction, they too have evolved mechanisms to trade their genetic material. In fact, bacteria not only could acquire many genes from close relatives, but also from entirely distant members through the process of horizontal gene transfer. Their success story of long evolutionary existence will stand testimony to these mechanisms. While teaching a course on Microbial Genetics to the post-graduate students at Delhi University, it was realized that a book devoted to bacterial genetics may be very handy to the students, researchers, and teachers alike. A strong foundation in genetics also helps in comprehending more modern concepts of molecular biology and recombinant DNA technology, always a favorite with the students and researchers. Planning the format of the book, emphasis has been laid on the generation and transmission of biological variability. The omission of expression part is indeed intentional because lots of information is available on this aspect in any modern biology book. The contents are spread over seven chapters and the text is supported with figures/tables wherever possible. The endeavor has been to induce the readers to appreciate the strength of bacterial genetics and realize the contribution of these tiny organisms to the growth of biological sciences as a whole and genetics in particular.

This volume summarizes recent advances in environmental microbiology by providing fascinating insights into the diversity of microbial life that exists on our planet. The first two chapters present theoretical perspectives that help to consolidate our understanding of evolution as an adaptive process by which the niche and habitat of each species develop in a manner that interconnects individual components of an ecosystem. This results in communities that function by simultaneously coordinating their metabolic and physiologic actions. The third contribution addresses the fossil record of microorganisms, and the subsequent chapters then introduce the microbial life that currently exists in various terrestrial and aquatic ecosystems. Coverage of the geosphere addresses endolithic organisms, life in caves and the deep continental biosphere, including how subsurface microbial life may impact spent nuclear fuel repositories. The discussion of the hydrosphere includes hypersaline environments and arctic food chains. By better understanding examples from the micro biosphere, we can elucidate the many ways in which the niches of different species, both large and small, interconnect within the overlapping habitats of this world, which is governed by its microorganisms.

"Advances in Botanical Research" publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences. The series features a wide range of reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology and ecology. Thisthematic volume features reviews on Genomic Insights into the Biology of Algae.
"Advances in Botanical Research" publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences. Features a wide range of reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology and ecology. Thisthematic volume features reviews on Genomic Insights into the Biology of Algae."

This book focuses on agricultural waste treatment and renewable energy production from the perspective of anaerobic digestion. It covers topics on anaerobic digestion processes and practices in various types of biogas plant construction and management and systematically addresses the principle and main features of three kinds of anaerobic digestion systems: household digesters, biogas septic tanks, and biogas plants. Instructive, informative and easy to understand, the book offers a valuable asset for researchers, technicians, graduate students and managerial personnel working in the areas of renewable energy, agricultural ecological engineering and the treatment and utilization of agricultural wastes.

This work brings together a number of accounts of the mechanisms whereby microorganisms are able to degrade a wide variety of compounds. These compounds range from petroleum-derived materials, which continue to predominate in questions of environmental contamination and pollution, to the degradation of the major natural materials that microorganisms may encounter in all types of habitat. Both aerobic and anaerobic modes of attack are covered. The emphasis in all the chapters is upon the underlying biochemical pathways that microorganisms use: differences between bacteria, yeasts and moulds are highlighted whenever opportune and uses of microbial consortia for attack on the most recalcitrant molecules is also documented. Activity of microorganisms in the soil, groundwater and marine environments are all considered. The book should be of interest to all whose work brings them into contact with the results of microbial degradations. The consequences of microbial degradations may be beneficial as well as deleterious: an advantage with some compounds, a decided disadvantage with others. The basis by which microorganisms achieve these attacks then provides the vital knowledge that will accelerate the former and, hopefully, retard the latter. The pathways of microbial degradations of all major classes of compounds are covered in a single volume. The diversity of microbial activities are clearly described and current advances in the applications of biochemistry, molecular biology, genetics, enzyme chemistry and engineering feature in almost every chapter.

This book contributes to better understand how lifestyle modulations can effectively halt the emergence and progression of human diseases. The book will allow the reader to gain a better understanding of the mechanisms by which the environment interferes with the bio-molecular regulatory processes underlying the emergence and progression of complex diseases, such as cancer. Focusing on key and early cellular bio-molecular events giving rise to the emergence of degenerative chronic disease, it builds on previous experience on the development of multi-cellular organisms, to propose a mathematical and computer based framework that allows the reader to analyze the complex interplay between bio-molecular processes and the (micro)-environment from an integrative, mechanistic, quantitative and dynamical perspective. Taking the wealth of empirical evidence that exists it will show how to build and analyze models of core regulatory networks involved in the emergence and progression of chronic degenerative diseases, using a bottom-up approach.

This volume focuses on those instances when benign and even beneficial relationships between microbes and their hosts opportunistically change and become detrimental toward the host. It examines the triggering events which can factor into these changes, such as reduction in the host's capacity for mounting an effective defensive response due to nutritional deprivation, coinfections and seemingly subtle environmental influences like the amounts of sunlight, temperature, and either water or air quality. The effects of environmental changes can be compounded when they necessitate a physical relocation of species, in turn changing the probability of encounter between microbe and host. The change also can result when pathogens, including virus species, either have modified the opportunist or attacked the host's protective natural microflora. The authors discuss these opportunistic interactions and assess their outcomes in both aquatic as well as terrestrial ecosystems, highlighting the impact on plant, invertebrate and vertebrate hosts.

Plant microbe interaction is a complex relationship that can have various beneficial impacts on both the communities. An urgent need of today's world is to get high crop yields in an ecofriendly manner. Utilization of beneficial and multifaceted plant growth promoting (PGP) microorganisms can solve the problem of getting enhanced yields without disturbing the ecosystem thus leading to sustainability. For this to achieve understanding of the intricate details of how the beneficial microbes form associations with the host plant and sustain that for millions of years must be known. A holistic approach is required wherein the diversity of microbes associated with plant and the network of mechanisms by which they benefit the host must be studied and utilized. 'Plant Microbe Symbiosis - Fundamentals and Advances' provides a comprehensive understanding of positive interactions that occur between plant and microorganisms and their utilization in the fields. The book reviews the enormous diversity of plant associated microbes, the dialog between plant-microbes-microbes and mechanisms of action of PGP microbes. Utilization of PGPRs as nutrient providers, in combating phytopathogens and ameliorating the stressed and polluted soils is also explained. Importantly, the book also throws light on the unanswered questions and future direction of research in the field. It illustrates how the basic knowledge can be amalgamated with advanced technology to design the future bioformulations.

Published since 1953, "Advances in Virus Research" covers a diverse range of in-depth reviews providing a valuable overview of the current field of virology. The impact factor for 2008 is 4.886, placing it 4th in the highly competitive category of virology.
Key features:

* Contributions from leading authorities * Informs and updates on all the latest developments in the field

This volume of the Trilogy of Traditional Foods, part of the ISEKI Food Series, describes important aspects of the production of foods and beverages from all over the globe. The intention of this volume is to provide readers with an appreciation of how products were initially made, and which factors have shaped their development over time. Some modern products have remained local, while others are commodities that appear in peoples' cabinets all over the world. Modernization of Traditional Food Processes and Products is divided into two sections. The first section focuses on products originating in Europe, while the second section is a collection of products from the rest of the world. Each chapter describes the origin of a particular food or beverage and discusses the changes and the science that led to the modern products found on supermarket shelves. The international List of Contributors, which includes authors from China, Thailand, India, Argentina, New Zealand, and the United Kingdom, attests to the international collaboration for which the ISEKI Food Series is known. The volume is intended for both the practicing food professional and the interested reader.

Since their discovery in 1869, the dictyostelids have attracted the attention of scientists in a wide variety of fields. This interest has stemmed from their peculiar lifestyle and developmental properties, which were shaped by the evolutionary forces that generated multicellularity during eukaryotic evolution. More recently, the dictyostelids have gained attention due to the striking similarities found at the genomic, cellular and biochemical levels with human cells, which has propelled the species Dictyostelium discoideum to become a model system for biology and medicine in many laboratories. This book covers the latest advances in our knowledge of these extraordinary organisms with topics spanning from their evolutionary history, ecology and diversity to the recent discoveries regarding their cellular and molecular biology.

Bacteria were the first life on Earth. But what do we really know about them? In this captivating, science-driven book, you'll learn everything you need to know about these often misunderstood-and incredibly interesting-microbes. In this engagingly written and scientifically rigorous book, author and scientist Ludger Wess introduces an eclectic collection of impressive, useful, weird, and dangerous bacterial species. Wess reveals everything he knows about bacteria, including their ability to survive almost anywhere, to "sleep" for millions of years before becoming active again, to maintain their own immune systems (a discovery that has led to medical breakthroughs for humans), and to-hypothetically-live on other planets. In part two, Wess moves on to his curious compendium of bacterial species, presenting fifty fascinating portraits grouped by useful categories: bacteria that are record holders, extreme-habitat dwellers, unusual consumers, people-helpers, and people-harmers. Beautiful black-and-white illustrations accompany each portrait. At the end of this engrossing read, Wess recognizes how much we still don't know about bacteria. But by starting here, we can come closer to understanding the first life on Earth.

This concise volume describes the latest, up-to-date theory, methodology, and applications of ABC transporters in microorganisms. The topics include the structure, physiology, and evolution of ABC transporters, as well as their special characteristics in specific microorganisms, including bacteria, yeast, trypanosomes, and malaria parasites. In particular, the book describes the most recent research and innovations relative to the role of ABC transporters in the design of strategies to circumvent drug resistance in microorganisms. Each chapter comprises an exhaustive review of the particular topic and provides insights into the future of the field, both from the scientific and clinical perspective. A skillful selection of topics and a panel of acknowledged experts ensure that this concise volume will be of exceptional importance to everyone involved in DNA superfamily research, as well as scientists interested in microbial physiology and multidrug resistance. It is essential reading for anyone involved in this field, and it is a recommended volume for all microbiology laboratories.

The rapid advancement of sequencing techniques, coupled with the new methodologies of bioinformatics to handle large-scale data analysis, are providing exciting opportunities for us to understand microbial communities from a variety of environments beyond previous imagination. This book provides up-to-date and detailed information on various aspects of bioinformatics data analysis with applications to microbiology.

Origin and General Nature of Retroviruses; H.M. Temin. Structure and Classification of Retroviruses; J.M. Coffin. Evolutionary Potential of Complex Retroviruses; G.M. Myers, G.N. Pavlakis. Retroelements in Microorganisms; D.J. Garfinkel. Biology of Avian Retroviruses; L.N. Payne. Retroviruses in Rodents; C.A. Kozak, S. Ruscetti. 1 additional article. Index.

"Advances in Cancer Research" provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.
113th volume of Advances in Cancer ResearchExpert authorsChapters on topics including microRNA regulatory network, multifaceted oncoprotein tax, and underlying chromosomal translocations

This volume, the first of a two-part series, covers topics including historical, ecological and evolutionary considerations, genomics and molecular biology, and interaction of phages with their hosts.
Key features:

* Contributions from leading authorities * Informs and updates on all the latest developments in the field

This volume focuses on the developmental areas of biopesticides: production, formulation, application and field efficacy. Chapters guide readers through methods and techniques on environmental, mammalian, safety, and registration. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Microbial-Based Biopesticides aims to ensure successful results in the further study of this vital field.

This book presents the latest results in the exploration of halophilic bacteria, archaea, fungi and viruses. Basic and molecular aspects as well as possible biotechnological applications of halophiles are highlighted by leading scientists. Topics include: the family "Halomonadaceae"; the hypersaline lakes of Inner Mongolia; "Salinibacter ruber" - from genomics to microevolution and ecology"; "the" "impact of lipidomics on the microbial world of hypersaline environments; molecular mechanisms of adaptation to high salt concentration in the black yeast "Hortaea werneckii"; viruses in hypersaline environments; initiation and regulation of translation in halophilic Archaea; protein transport into and across haloarchaeal cytoplasmic membranes; protein glycosylation in "Haloferax volcanii"; the effect of anoxic conditions and temperature on gas vesicle formation in "Halobacterium salinarum"; halophiles exposed to multiple stressors; cellular adjustments of "Bacillus subtilis" to fluctuating salinities; the nature and function of carotenoids in "Halobacillus halophilus"; xanthorhodopsin; enzymatic biomass degradation by halophilic microorganisms; and enzymes from halophilic Archaea.

This volume summarizes recent advances in our understanding of the mechanisms that produce successful symbiotic partnerships involving microorganisms. It begins with a basic introduction to the nature of and mechanistic benefits derived from symbiotic associations. Taking that background knowledge as the starting point, the next sections include chapters that examine representative examples of coevolutionary associations that have developed between species of microbes, as well as associations between microbes and plants. The authors conclude with a section covering a broad range of associations between microbes and invertebrate animals, in which they discuss the spectrum of hosts, with examples ranging from bryozoans and corals to nematodes, arthropods, and cephalopods. Join the authors on this journey of understanding!

Molecular Structure of the Arenaviruses: Arenavirus Ultrastructure and Morphogenesis; R.W. Compans. Glycoproteins of the Arenaviruses; J.W. Burns, M.J. Buchmeier. Antigenic Diversity among the Arenaviruses; C.R. Howard. Genetic Variation in Junin Virus; C.E. Coto, et al. Mechanism of Arenavirus RNA Synthesis; D. Kolakofsky, D. Garcin. Subgenomic RNAs of Tacaribe Virus; M.T. Franze-Fernandez, et al. Arenavirus Cellular Tropisms and Virulence; D.G. Harnish, et al. Immuno-Pathology, Vaccines, and Epidemiology Lymphocutic Choriomeningitis Virus; C.J. Pfau, A.R. Thomsen. Molecular Anatomy of the Cytotoxic T Lymphocyte Response to Lympocytic Choriomeningitis Virus; L.S. Klavinskis, et al. Virus Induced Acquire Immune Suppression by T Cell Mediated Immunopathology and Vaccine Strategies; R.M. Zinkernagel. Construction and Evaluation of Vaccines for Lassa Fever; D.D. Auperin. 8 additional articles. Index.

The second part of an updated edition of the classic "Methods in Cell Biology, "Volume 48, this book emphasizes diverse methods and technologies needed to investigate "C. elegans," both as an integrated organism and as a model system for research inquiries in cell, developmental, and molecular biology, as well as in genetics and pharmacology. By directing its audience to tried-and-true and cutting-edge recipes for research, this comprehensive collection is intended to guide investigators of "C. elegans" for years to come.
Diverse, up-to-date techniques covered will be useful to the broadening community of "C. elegans" researchers for years to comeChapters written by leaders in the fieldTried and true methods deliver busy researchers a one-stop compendium of essential protocols