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Books > Science & Mathematics > Biology, life sciences > Microbiology (non-medical)

The Handbook of Microbiological Media for the Examination of Food (Hardcover, 2nd edition): Ronald M. Atlas The Handbook of Microbiological Media for the Examination of Food (Hardcover, 2nd edition)
Ronald M. Atlas
R6,269 Discovery Miles 62 690 Ships in 12 - 17 working days

Presents descriptions and the most efficient uses for nearly 1400 media Includes a concise yet comprehensive introduction to food microbiology Offers an extensive index for quick access in addition to alphabetical organization Contains an extensive appendix that includes trademarks, a composition glossary, growth factors, and FDA recommendations for media choices Responding to an estimated 14 million cases of food-borne disease that occur every year in the United States alone, the Food and Drug Administration and US Department of Agriculture have begun implementing new regulations and guidance for the microbial testing of foods. Similarly, Europe and other regions are implementing stricter oversight, as foodborne pathogens that cause deadly diseases such as e. coli 0157: H7 have raised the stakes everywhere. Food safety scientists have acted on this growing public health risk by developing improved media for the cultivation of bacteria, fungi, and viruses, much of it geared toward specific rapid detection. Reflecting the development of these new media and the latest FDA recommendations, the second edition of the Handbook of Microbiological Media for the Examination of Food provides an essential resource for anyone involved with the monitoring of both food production and post-production quality control. Organized alphabetically by medium, the expanded edition of this highly respected handbook includes - Descriptions of nearly 1,400 media including those recommended by the FDA, as well as media used elsewhere in the world Concise and lucid instructions for the preparation and uses of each of the media Cross-referenced indexing that allows the media to be found by name or specific microorganism of interest Descriptions of expected results as they apply to microorganisms of importance for the examination of foods Common synonyms for the various media and listings of compositions, so that alternate media an be effectively employed

Advances in Dairy Microbial Products (Hardcover): Joginder Singh, Ashish Vyas Advances in Dairy Microbial Products (Hardcover)
Joginder Singh, Ashish Vyas
R5,069 Discovery Miles 50 690 Ships in 12 - 17 working days

Advances in Dairy Microbial Products describes the importance and utility of microbial products used in dairy products. This book explains the makeup of these products in a scientifically sound yet simple manner. The appeal of this book is its holistic approach to addressing the different aspects of the dairy industry, from basic dairy microbial biochemistry to production of dairy products and their nutrient quality, and finally to machine learning applications in dairy industry. Comprised of chapters written and edited by international authorities and researchers with top expertise in dairy products, it offers both established and cutting-edge solutions to the numerous challenges commonly encountered in the industrial processing of milk and the production of milk products. This book offers a highly practical approach to the topic, addressing and tackling the problems faced in the workplace by dairy technologists. Researchers and practitioners will find this book to be an ideal source of thorough and up-to-date information on dairy microbial products while also appealing to beginners seeking to understand how advanced dairy technologies can increase the efficiency of current techniques.

Handbook of Media for Environmental Microbiology (Hardcover, 2nd edition): Ronald M. Atlas Handbook of Media for Environmental Microbiology (Hardcover, 2nd edition)
Ronald M. Atlas
R6,297 Discovery Miles 62 970 Ships in 12 - 17 working days

The second edition of a bestseller, this book provides a comprehensive reference for the cultivation of bacteria, Archaea, and fungi from diverse environments, including extreme habitats. Expanded to include 2,000 media formulations, this book compiles the descriptions of media of relevance for the cultivation of microorganisms from soil, water, and air. The format allows easy reference to the information needed to prepare media for the cultivation of microorganisms required for environmental analysis, including the determination of water safety. The media are organized alphabetically, and each listing includes medium composition, instructions for preparation, commercial sources, and uses.

Preventable - How a Pandemic Changed the World & How to Stop the Next One (Hardcover): Devi Sridhar Preventable - How a Pandemic Changed the World & How to Stop the Next One (Hardcover)
Devi Sridhar
R640 R526 Discovery Miles 5 260 Save R114 (18%) Ships in 9 - 15 working days

**THE SUNDAY TIMES BESTSELLER | BBC RADIO 4 BOOK OF THE WEEK** Preventable tells the extraordinary story of COVID-19 and how global politics shape our health - from a world-leading expert and the pandemic's go-to science communicator Professor Devi Sridhar has risen to prominence for her vital roles in communicating science to the public and speaking truth to power. In Preventable she highlights lessons learned from outbreaks past and present in a narrative that traces the COVID-19 pandemic - including her personal experience as a scientist - and sets out a vision for how we can better protect ourselves from the inevitable health crises to come. In gripping and heartfelt prose, Sridhar exposes the varied realities of those affected (from the jailed doctor in Wuhan who sounded the alarm, and the bored passengers marooned on the Diamond Princess cruise ship, to the daily nightmares of exhausted healthcare workers), and puts you in the room with key decision makers at crucial moments (from over-confident heads of states and their hesitant scientific advisors, to the beleaguered leaders of global health organisations). Sridhar vibrantly conveys the twists and turns of a plot that saw: deadlier variants emerge (contrary to the predictions of social media pundits who argued it would mutate to a milder form); the Pyrrhic victory in many countries of the false narrative of health versus the economy (those countries which controlled the virus, like Taiwan and Denmark, had a steadier recovery); countries with weak health systems like Senegal and Vietnam fare better than countries like the US and UK (which were consistently ranked as the most prepared); and the quickest development of game-changing vaccines in history (and their unfair distribution). Combining science, politics, ethics and economics, this definitive book dissects the global structures that determine our fate, and reveals the deep-seated economic and social inequalities at their heart - it will challenge, outrage and inspire. 'A brutally compelling reminder that if voices like Devi's had been listened to, so many more could have lived' OWEN JONES 'One of the most brilliant scientists in the world who has been proven consistently right in this crisis' PIERS MORGAN 'Excellent . . . Fair, clear and compelling' NICOLA STURGEON 'Those who have found Professor Devi Sridhar's expertise and calm advice invaluable since the arrival of Covid-19 will be glad to know that she has written Preventable' RACHEL COOKE, Guardian, Non-fiction to look out for in 2022

Parasites of Homo sapiens - An Annotated Checklist of the Protozoa, Helminths and Arthropods for which we are Home (Hardcover,... Parasites of Homo sapiens - An Annotated Checklist of the Protozoa, Helminths and Arthropods for which we are Home (Hardcover, 2 Rev Ed)
Richard Ashford, William Crewe
R3,234 Discovery Miles 32 340 Ships in 12 - 17 working days


Contents:
Part 1. Protozoa Part 2. Trematoda Part 3. Cestoda Part 4. Nematoda Part 5. Acanthocephala Part 6. Arthropoda References

Advances in Applied Microbiology, Volume 117 (Hardcover): Geoffrey M. Gadd, Sima Sariaslani Advances in Applied Microbiology, Volume 117 (Hardcover)
Geoffrey M. Gadd, Sima Sariaslani
R3,653 Discovery Miles 36 530 Ships in 12 - 17 working days

Advances in Applied Microbiology, Volume 117 continues the comprehensive reach of this widely read and authoritative review source in microbiology. Users will find invaluable references and information on a variety of areas relating to the topic of microbiology.

Rapid Microbiological Methods in the Pharmaceutical Industry (Hardcover): Martin C. Easter Rapid Microbiological Methods in the Pharmaceutical Industry (Hardcover)
Martin C. Easter
R11,330 Discovery Miles 113 300 Ships in 12 - 17 working days

In recent years there has been increased interest in the possibility of rapid microbiological methods offering enhanced potential error detection capabilities. However, these methods raise a number of questions, such as how to validate new methods, will they be accepted by the pharmacopoeias, and, most importantly, how will the regulators respond? Rapid Microbiological Methods in the Pharmaceutical Industry answers these questions and more. Martin Easter and his panel of experts: Describe the range of rapid microbiological methods and their applications, including practical tips, and their status regarding validation, established use, and regulatory acceptance Explore the origins of current methods and the current issues facing the requirements of microbiology and its associated test methods Delineate the challenges involved in seeking better and more pragmatic methods for the assessment of microbial hazards and risks to ensure product and consumer safety The book assists you in applying an effective system to assess the real microbiological hazards and, hence, quantify realistic risks. Additionally, it provides monitoring methods that will deliver meaningful, useful data for effective decision making in manufacturing, quality assurance, and product safety. The expert and authoritative information in Rapid Microbiological Methods in the Pharmaceutical Industry will help you find better solutions to ensuring the microbiological safety of pharmaceutical products. Features

Microbial Biopesticides (Hardcover): Opender Koul, G.S. Dhaliwal Microbial Biopesticides (Hardcover)
Opender Koul, G.S. Dhaliwal
R6,256 Discovery Miles 62 560 Ships in 12 - 17 working days


Biotechnological research has provided key developments in pest control agents, focusing on pathogens of insect pests as formulated biological pesticides. Emphasis has been placed on bacteria and viruses as they are well understood and easily manipulated.
This volume provides a comprehensive overview of the advances made in the use of bacteria, fungi and viruses, focusing on behavioural, chemical and molecular aspects. The authors discuss the potential of nematode-based biochemical agents and bioherbicids and explore the role of microbial biopesticides in integrated pest management and their prospects for commercil exploitation.

eBook available with sample pages: 0203303075

Fighting Infection in the 21st Century (Hardcover): P.W. Andrew, G. L Smith, D.E.S.Stewart- Tull, P Oyston Fighting Infection in the 21st Century (Hardcover)
P.W. Andrew, G. L Smith, D.E.S.Stewart- Tull, P Oyston
R4,531 R3,605 Discovery Miles 36 050 Save R926 (20%) Ships in 7 - 13 working days

The 20th century has seen improvements in both public health and disease prevention which, in turn, have had a dramatic impact on our lives. Success in preventing infection by vaccination and treating infection with antibiotics led some to believe that infectious disease was a thing of the past. However, the adaptability of pathogens and the emergence of new diseases has presented microbiologists with a fresh set of challenges as we enter the new millennium. While celebrating past successes and highlighting developing problems, this volume aims to address some of the issues facing microbiologists in the future. Covering a wide range of topics, it will provide an invaluable resource for microbiologists and an excellent reference for advanced students.

Integrated and Hybrid Process Technology for Water and Wastewater Treatment (Paperback): Abdul Wahab Mohammad, Wei Lun Ang Integrated and Hybrid Process Technology for Water and Wastewater Treatment (Paperback)
Abdul Wahab Mohammad, Wei Lun Ang
R4,683 Discovery Miles 46 830 Ships in 12 - 17 working days

Tackling the issue of water and wastewater treatment nowadays requires novel approaches to ensure that sustainable development can be achieved. Water and wastewater treatment should not be seen only as an end-of-pipe solution but instead the approach should be more holistic and lead to a more sustainable process. This requires the integration of various methods/processes to obtain the most optimized design. Integrated and Hybrid Process Technology for Water and Wastewater Treatment discusses the state-of-the-art development in integrated and hybrid treatment processes and their applications to the treatment of a vast variety of water and wastewater sources. The approaches taken in this book are categorized as (i) resources recovery and consumption, (ii) optimal performance, (iii) physical and environmental footprints, (iv) zero liquid discharge concept and are (v) regulation-driven. Through these categories, readers will see how such an approach could benefit the water and wastewater industry. Each chapter discusses challenges and prospects of an integrated treatment process in achieving sustainable development. This book serves as a platform to provide ideas and to bridge the gap between laboratory-scale research and practical industry application.

Microbes in Land Use Change Management (Paperback): Jay Shankar Singh, Shashank Tiwari, Chhatarpal Singh, Anil Kumar Singh Microbes in Land Use Change Management (Paperback)
Jay Shankar Singh, Shashank Tiwari, Chhatarpal Singh, Anil Kumar Singh
R3,215 Discovery Miles 32 150 Ships in 12 - 17 working days

Microbes in Land Use Change Management details the various roles of microbial resources in management of land uses and how the microbes can be used for the source of income due to their cultivation for the purpose of biomass and bioenergy production. Using various techniques, the disturbed and marginal lands may also be restored eco-friendly in present era to fulfil the feeding needs of mankind around the globe. Microbes in Land Use Change Management provides standard and up to date information towards the land use change management using various microbial technologies to enhance the productivity of agriculture. Needless to say that Microbes in Land Use Change Management also considers the areas including generation of alternative energy sources, restoration of degraded and marginal lands, mitigation of global warming gases and next generation -omics technique etc. Land use change affects environment conditions and soil microbial community. Microbial population and its species diversity have influence in maintaining ecosystem balance. The study of changes of microbial population provides an idea about the variation occurring in a specific area and possibilities of restoration. Meant for a multidisciplinary audience Microbes in Land Use Change Management shows the need of next-generation omics technologies to explore microbial diversity.

Industrielle Mikrobiologie (Paperback, 2013 ed.): Hermann Sahm, Garabed Antranikian, Klaus-Peter Stahmann, Ralf Takors Industrielle Mikrobiologie (Paperback, 2013 ed.)
Hermann Sahm, Garabed Antranikian, Klaus-Peter Stahmann, Ralf Takors
R1,219 Discovery Miles 12 190 Ships in 12 - 17 working days

Die Industrielle Mikrobiologie vereint das Fachwissen von Naturwissenschaftlern und Ingenieuren uber die Nutzung von Bakterien und Pilzen. Als innovative Querschnittsdisziplin bietet sie wichtige Voraussetzungen fur die Entwicklung konkurrenzfahiger Produkte auf der Basis umweltschonender Verfahren. So setzt z.B. die chemische Industrie heute bereits Mikroorganismen in Prozessen ein, um Rohstoffe und Energie sparen. In dieser Branche besteht ein zunehmender Bedarf an gut ausgebildeten Fachkraften.

Dieses neue Lehrbuch wurde von erfahrenen Wissenschaftlern aus Hochschulen und der Industrie verfasst. Es soll Studierende aus Life Science-Bachelorstudiengangen sowie fortgeschrittene Studierende der Chemie oder der Ingenieurwissenschaften in die Industrielle Mikrobiologie einfuhren. Es vermittelt die Grundlagen der Entwicklung von Produktionsstammen und erklart spezielle Verfahren zur Herstellung mikrobieller Produkte. Dabei wird aufgezeigt, wie das Potential der Mikroorganismen optimal genutzt werden kann.

Zunachst wird ein Uberblick uber die geschichtliche Entwicklung der Industrielle Mikrobiologie und eine Einfuhrung in die Bioverfahrenstechnik gegeben. Anschliessend werden in 10 Kapiteln ausgewahlte mikrobielle Verfahren zur Herstellung von Lebensmitteln, organischen Sauren, Alkoholen, Aminosauren, Vitaminen, Antibiotika, Pharmaproteinen, Enzymen, Biopolymeren sowie Steroiden und Aromastoffen beschrieben. Im letzten Kapitel wird am Beispiel der biologischen Abwasserreinigung aufgezeigt, dass die Mikroorganismen nicht nur ein enormes Synthese-, sondern auch ein grosses Abbaupotential besitzen, mit dem sie einen Beitrag zu den Stoffwechselkreislaufen auf unserer Erde leisten.

Die Autoren wunschen sich, dass dieses Lehrbuch das Interesse vieler Studierender an diesem spannenden Lehr- und Forschungsgebiet weckt und sie daraus Nutzen ziehen konnen, um dann selbst zur weiteren Entwicklung der Industriellen Mikrobiologie beizutragen.

Genetically Engineered Viruses - Development and Applications (Paperback): Eddie Blair, Chris J. A. Ring Genetically Engineered Viruses - Development and Applications (Paperback)
Eddie Blair, Chris J. A. Ring
R2,686 Discovery Miles 26 860 Ships in 12 - 17 working days

This book combines an up-to-date summary of how best to genetically engineer viruses with an overview of basic virology. This unique combination makes it an invaluable research tool for virologists and molecular biologists seeking to exploit viruses for a range of applications. Written by highly respected authors, the book also provides comparisons to and guidelines for the use of viruses in difference applications.

Metal Ions in Biological Systems - Volume 37: Manganese and Its Role in Biological Processes (Hardcover): Helmut Sigel Metal Ions in Biological Systems - Volume 37: Manganese and Its Role in Biological Processes (Hardcover)
Helmut Sigel
R11,407 Discovery Miles 114 070 Ships in 12 - 17 working days

"Highlights the availability of magnesium to organisms, its uptake and transport in microorganisms and plants as well as its role in health and disease of animals and humans including its toxicology."

Bacterial Resistance to Antimicrobials (Paperback, 2nd edition): Richard G. Wax, Kim Lewis, Abigail A. Salyers, Harry Taber Bacterial Resistance to Antimicrobials (Paperback, 2nd edition)
Richard G. Wax, Kim Lewis, Abigail A. Salyers, Harry Taber
R1,980 Discovery Miles 19 800 Ships in 12 - 17 working days

The enormous genetic flexibility of bacteria jeopardizes the usefulness of currently available antibiotics, and requires new approaches to antibiotic discovery and development. Antimicrobial resistance can be acquired in a short time frame, both by genetic mutation and by direct transfer of resistance genes across genus and species boundaries. Understanding mechanisms of resistance is crucial to the future of antimicrobial therapy. Extensively revised, with contributions from international leaders in their fields, Bacterial Resistance to Antimicrobials, Second Edition blends scientific and practical approaches to the social, economic, and medical issues related to this growing problem. The book begins with a history of antimicrobial agents and bacterial resistance, and outlines the forces that contributed to the abuse of antibiotics and precipitated the current crisis. It goes on to describe what is known about the ecology of antibiotic resistant bacteria and reveals the inadequacies in our understanding. Emphasizing public health aspects, the editors stress that significant progress will be made only by addressing the problem only as a public, worldwide, problem. Chapters on resistance mechanisms describe the latest findings on what makes different groups of bacteria susceptible or resistant to antibiotics. They reveal the staggering diversity of bacteria and the need for a foundational understanding that will stimulate development of antibiotics capable of avoiding resistance mechanisms. Examining the success and limitations of complementary approaches, such as combining ss-lactam antibiotics with ss-lactamase inhibitors, the book brings together information on resistance mechanisms in different groups of bacteria to help future efforts to more effectively develop and deploy antimicrobial therapies.

Review Questions for Microbiology and Immunology - A Review for the USMLE, Step 1, 2 and 3 Examinations (Paperback, annotated... Review Questions for Microbiology and Immunology - A Review for the USMLE, Step 1, 2 and 3 Examinations (Paperback, annotated edition)
A.C. Reese, C.N. Nair, G.H. Brownell
R1,498 Discovery Miles 14 980 Ships in 12 - 17 working days

This is a review text on medical microbiology and immunology containing approximately 625 board-type review questions on left-hand pages with answers and explanations on facing right-hand pages. It is designed for medical students taking microbiology as well as for those studying for Step 1 of the National Board Exams and is also useful for Step 3 National Boards on infectious diseases or allergy and immunology. The book's main sections cover general and medical microbiology, bacteriology, virology, immunology, and parasitology. The answers summarize relevant information and point out the fault in incorrect answers. Line drawings and figures are used for questions concerning structure of both molecules and organisms and for interpreting graphical results. Authors Reese, Brownell, and Nair, all with the Medical College of Georgia, bring a combined total of some 85 years of medical school teaching experience to their development of the questions and annotated answers for this book.

Advances in Probiotics - Microorganisms in Food and Health (Paperback): Dharumaurai Dhansekaran, Alwarappan Sankaranarayanan Advances in Probiotics - Microorganisms in Food and Health (Paperback)
Dharumaurai Dhansekaran, Alwarappan Sankaranarayanan
R4,274 Discovery Miles 42 740 Ships in 12 - 17 working days

Advances in Probiotics: Microorganisms in Food and Health highlights recent advances in probiotic microorganisms, commercial probiotics, safety aspects of probiotics, preparation and commercialization, microbiome therapy for diseases and disorders, and next generation probiotics. This is a comprehensive resource of developments of new formulations and products for probiotic and prebiotic food with focus on the microorganisms to enable effective probiotic delivery. The book deliberates contemporary trends and challenges, risks, limitations in probiotic and prebiotic food to deliver an understanding not only for research development purposes but also to benefit further standardize industrial requirements and other techno-functional traits of probiotics. At present there is no solitary volume to describe the probiotics and prebiotics properties, Advances in Probiotics: Microorganisms in Food and Health provides novel information to fill the overall gap in the market. It presents the most current information on probiotic and prebiotics for the food industry. This book is a valuable resource for academicians, researchers, food industrialists, and entrepreneurs.

Infection and Immunity (Paperback): D H Davies, M. A. Halablab, T.W.K. Young, F. E. G. Cox, J. Clarke Infection and Immunity (Paperback)
D H Davies, M. A. Halablab, T.W.K. Young, F. E. G. Cox, J. Clarke
R1,506 Discovery Miles 15 060 Ships in 12 - 17 working days

This concise text explores the interactions between pathogens and the immune system. Taking a disease-based approach, it explains how micro-organisms adapted to growth in human hosts can evade the immune system and cause disease. The opening chapter overviews the innate and adaptive immune responses to microbes. Subsequent chapters are specific to particular pathogens, beginning with their biology and leading on to illustrate mechanisms of adaptation and ensuing consequences. Each of these chapters ends with a summary, review questions and further reading lists. The text includes: Concise yet comprehensive discussion of pathogens from the viruses, bacteria, fungi, protozoan parasites and helminth worms. Summaries, review questions and further reading make this book suitable for self-directed study. Infection and Immunity is ideal for any undergraduates taking a course that explores the interaction between pathogens and the human immune system.

Design and Analysis of Ecological Experiments (Hardcover, New): Sam Scheiner Design and Analysis of Ecological Experiments (Hardcover, New)
Sam Scheiner
R4,627 Discovery Miles 46 270 Ships in 12 - 17 working days

The goal of this book is to make some underutilized but potentially very useful methods in experimental design and analysis available to ecologists, and to encourage better use of standard statistical techniques. Ecology has become more and more an experimental science in both basic and applied work, but experiments in the field and in the laboratory often present formidable statistical difficulties. Organized around providing solutions to ecological problems, this book offers ways to improve the statistical aspects of conducting manipulative ecological experiments, from setting them up to interpreting and reporting the results. An abundance of tools, including advanced approaches, are made available to ecologists in step-by-step examples, with computer code provided for common statistical packages. This is an essential how-to guide for the working ecologist and for graduate students preparing for research and teaching careers in the field of ecology.

Advances in Microbial Physiology, Volume 78 (Hardcover): Robert K. Poole, David J. Kelly Advances in Microbial Physiology, Volume 78 (Hardcover)
Robert K. Poole, David J. Kelly
R4,145 Discovery Miles 41 450 Ships in 12 - 17 working days

Advances in Microbial Physiology, Volume 78, the latest release in this ongoing series, continues the long tradition of topical, important, cutting-edge reviews in microbiology. This updated release contains the latest information in the field, with comprehensive chapters covering Microbubble Intensification of Bioprocessing, Bacterial cellulose: biosynthesis, production, and applications, Microbial energy management - a product of three broad tradeoffs, and more.

Advances in Trematode Biology (Hardcover): Bernard Fried Advances in Trematode Biology (Hardcover)
Bernard Fried; Contributions by A. G. M. Tielens; Edited by Thaddeus K. Graczyk; Contributions by Aaron G Maule, David W. Halton, …
R8,816 Discovery Miles 88 160 Ships in 12 - 17 working days

Trematodology - the study of a class of medically important parasitic, flat-bodied worms - has made significant advances over the past ten years. The tremendous amount of information accumulated from research discoveries and technical developments related to trematode biology makes this book a timely and necessary part of the literature. Advances in Trematode Biology presents a thorough treatment of modern trematodology, including principles and practices. With coverage of background material as well as modern methods, Advances in Trematode Biology updates researchers, practitioners, and students with new information in immunology, biochemistry, physiology, and molecular biology.
Advances in Trematode Biology includes practical information on parasitological techniques, emphasizing species of medical and veterinary importance - a key reference for parasitologists, biologists, medical, and veterinary personnel. The excellent presentation of material, including well-organized tables and chapters, make Advances in Trematode Biology easy to use both as a textbook and as a reference.

Proteomics Approaches to Unravel Virus - Vertebrate Host Interactions, Volume 109 (Hardcover): Gisa Gerold Proteomics Approaches to Unravel Virus - Vertebrate Host Interactions, Volume 109 (Hardcover)
Gisa Gerold
R4,397 Discovery Miles 43 970 Ships in 12 - 17 working days

Proteomics Approaches to Unravel Virus - Vertebrate Host Interactions, Volume 109 in the Advances in Virus Research series, highlights state-of-the art mass spectrometry techniques to elucidate the tight interplay of vertebrate viruses and their host cells. The volume includes chapters on Spatio-temporal resolution of host protein complexes during virus entry, Proteomic approaches to investigate gammaherpesvirus biology and associated tumorigenesis, Applications of Mass Spectrometry Imaging in Virus Research, Mapping surfaceome dynamics during viral infection, Characterization of proteolytic events in virus-host interactions, Dynamic protein network modulation upon viral infection, and much more.

Germfree and Gnotobiotic Animal Models - Background and Applications (Hardcover, New): Bernard S. Wostmann Germfree and Gnotobiotic Animal Models - Background and Applications (Hardcover, New)
Bernard S. Wostmann
R3,235 Discovery Miles 32 350 Ships in 12 - 17 working days

The germfree animal is reared in the laboratory to be bacteria free; its counterpart, the gnotobiotic animal, is exposed to select microorganisms. The need for such an animal model for use in biomedical studies was first expressed by Pasteur in the late 1800s. Subsequent development of germfree and gnotobiotic animals led to an explosion of studies on the effects of microflora and its components on the physiology and metabolism of the host. Germfree and Gnotobiotic Animal Models brings together the most notable points of early and recent studies and gives reference to the most pertinent literature.

Autophagy and Senescence in Cancer Therapy, Volume 150 (Hardcover): Paul B. Fisher, David A. Gewirtz Autophagy and Senescence in Cancer Therapy, Volume 150 (Hardcover)
Paul B. Fisher, David A. Gewirtz
R3,933 Discovery Miles 39 330 Ships in 12 - 17 working days

Advances in Cancer Research, Volume 150, the latest release in this ongoing series, covers the relationship(s) between autophagy and senescence, how they are defined, and the influence of these cellular responses on tumor dormancy and disease recurrence. Specific sections in this new release include Autophagy and senescence, converging roles in pathophysiology, Cellular senescence and tumor promotion: role of the unfolded protein response, autophagy and senescence in cancer stem cells, Targeting the stress support network regulated by autophagy and senescence for cancer treatment, Autophagy and PTEN in DNA damage-induced senescence, mTOR as a senescence manipulation target: A forked road, and more.

Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria (Hardcover): F.J. de Bruijn Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria (Hardcover)
F.J. de Bruijn
R13,741 R10,834 Discovery Miles 108 340 Save R2,907 (21%) Ships in 7 - 13 working days

Bacteria in various habitats are subject to continuously changing environmental conditions, such as nutrient deprivation, heat and cold stress, UV radiation, oxidative stress, dessication, acid stress, nitrosative stress, cell envelope stress, heavy metal exposure, osmotic stress, and others. In order to survive, they have to respond to these conditions by adapting their physiology through sometimes drastic changes in gene expression. In addition they may adapt by changing their morphology, forming biofilms, fruiting bodies or spores, filaments, Viable But Not Culturable (VBNC) cells or moving away from stress compounds via chemotaxis. Changes in gene expression constitute the main component of the bacterial response to stress and environmental changes, and involve a myriad of different mechanisms, including (alternative) sigma factors, bi- or tri-component regulatory systems, small non-coding RNA s, chaperones, CHRIS-Cas systems, DNA repair, toxin-antitoxin systems, the stringent response, efflux pumps, alarmones, and modulation of the cell envelope or membranes, to name a few. Many regulatory elements are conserved in different bacteria; however there are endless variations on the theme and novel elements of gene regulation in bacteria inhabiting particular environments are constantly being discovered. Especially in (pathogenic) bacteria colonizing the human body a plethora of bacterial responses to innate stresses such as pH, reactive nitrogen and oxygen species and antibiotic stress are being described. An attempt is made to not only cover model systems but give a broad overview of the stress-responsive regulatory systems in a variety of bacteria, including medically important bacteria, where elucidation of certain aspects of these systems could lead to treatment strategies of the pathogens. Many of the regulatory systems being uncovered are specific, but there is also considerable cross-talk between different circuits. Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria is a comprehensive two-volume work bringing together both review and original research articles on key topics in stress and environmental control of gene expression in bacteria. Volume One contains key overview chapters, as well as content on one/two/three component regulatory systems and stress responses, sigma factors and stress responses, small non-coding RNAs and stress responses, toxin-antitoxin systems and stress responses, stringent response to stress, responses to UV irradiation, SOS and double stranded systems repair systems and stress, adaptation to both oxidative and osmotic stress, and desiccation tolerance and drought stress. Volume Two covers heat shock responses, chaperonins and stress, cold shock responses, adaptation to acid stress, nitrosative stress, and envelope stress, as well as iron homeostasis, metal resistance, quorum sensing, chemotaxis and biofilm formation, and viable but not culturable (VBNC) cells. Covering the full breadth of current stress and environmental control of gene expression studies and expanding it towards future advances in the field, these two volumes are a one-stop reference for (non) medical molecular geneticists interested in gene regulation under stress.

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