An in-depth resource addressing the ecology of Clostridium botulinum which affects the degree of food contamination, and its control in various foods. The text summarizes worldwide data on this organism in food and the environment and the principles of its control in specific foods and products.

Thermophilic Bacteria is a comprehensive volume that describes all major bacterial groups that can grow above 60-65 DegreesC (excluding the Archaea). Over 60 different species of aerobic and anaerobic thermophilic bacteria are covered. Isolation, growth methods, characterization and identification, ecology, metabolism, and enzymology of thermophilic bacteria are examined in detail, and an extensive compilation of recent biotechnological applications and the properties of many thermostable enzymes are also included. Major topics discussed in the book include a general review on thermophilic bacteria and archaea; heterotropic bacilli; the genus Thermus; new and rare genera of aerobic heterophophs, such as Saccharococcus, Rhodothermus, and Scotohermus; aerobic chemolithoautotrophic thermophilic bacteria; obligately anaerobic thermophilic bacteria; and hyperthermophilic Thermotogales and thermophilic phototrophs. Extensive bibliographies are also provided for each chapter. The vast amount of information packed into this one volume makes it essential for all microbiologists, biochemists, molecular biologists, and students interested in the expanding field of thermophilicity. Biotechnologists will find the book useful as a source of information on thermophiles or thermostable enzymes of possible industrial use.

Based on a workshop held at the Sante Fe Institute in June,1990, this book explores structure in organisms-both physical and dynamical-and presents the current status of the search for natural pathways, principles of organization, and the theory of design for organisms. Topic discussed include dynamical systems analysis; the pathways of evolution; development, physiology, and functional morphology; and the principles of dynamical change in connectivity within the networks of processes.

Antimicrobial Activity of Nanoparticles: Applications in Wound Healing and Infection Treatment presents the state of the art among nanotechnological approaches used in the treatment of infections. This field has gained a large amount of interest over the past few years, in response to the increasing resistance of pathogens to antibiotics. Leading researchers from around the world discuss the synthesis routes of nanobiomaterials, characterization, and their applications as antimicrobial agents. The book covers various aspects: from antiviral and antibacterial nanoparticles, to the functionalization of nanoparticles and their toxicity to human cells. This book offers an advanced reference text for biomedical engineers, materials scientists, clinicians, and biochemists, with an interest in nanomedicine and infection control.

The Beans and the Peas: From Orphan to Mainstream Crops presents a comprehensive literature resource on the most important food legume crops previously known as "orphans," but which are increasingly becoming mainstream as their production opportunities have been improved through genetic improvement and biotechnology, and their role as an important nutrient source gains urgency. This book focuses on 12 important food legumes and discusses all relevant aspects on their economic importance, crop statistics, botany, and their general description. It also provides exhaustive information on plant genetic resources and their use, genetic improvement, resistance to biotic and abiotic stresses, improved varieties, agronomy, seed system, and use of information and communication tools in each individual food legume. Development of innovative biotechnological tools, genetic transformation, and the genome sequencing information has also been covered in each chapter providing the readers with state-of-the-art information on pulses. All chapters have been supported by relevant figures, illustrations, and tables, which make the contents accessible and easy to understand. Each of the chapters has been authored by globally known scientists/researchers presenting up-to-date information on various aspects of food legumes. This book provides a current and comprehensive treatise to the readers and will be tremendously helpful in furthering their academic and research pursuits.

Advances in Microbial Physiology, Volume 77, the latest release in this ongoing series, continues the long tradition of topical, important, cutting-edge reviews in microbiology. The updated release contains updates in the field, with comprehensive chapters covering Microbubble Intensification of Bioprocessing, Bacterial cellulose: biosynthesis, production, and applications, Microbial energy management - a product of three broad tradeoffs, and more.

Advances in Virus Research, Volume 108, in this ongoing series, highlights new advances in the field, with this new volume presenting interesting chapters on topics including Virus infections of the developing brain, Geminivirus assembly, Flavivirus assembly, Cell-cell transmission, Archael virus assembly, Potyvirus assembly, Poxvirus assembly and exit, Mycovirus assembly, Reo/orbivirus assembly and exit, Giant virus assembly, Quasi-enveloped virus assembly/exit, and Betaherpesvirus assembly and exit.

This book captures some of the essential developments, both historical and current, relating to the human retroviruses and the diseases they cause. It describes detailed molecular biology and epidemiology of human T-leukemia virus type 1 (HTLV-1).

Focuses on the aggregation of recombinant proteins in bacterial cells in the form of inclusion bodies and on their use in biotechnological and medical applications The first book devoted specifically to the topic of aggregation in bacteria, Protein Aggregation in Bacteria: Functional and Structural Properties of Inclusion Bodies in Bacterial Cells provides a large overview of protein folding and aggregation, including cell biology and methodological aspects. It summarizes, for the first time in one book, ideas and technical approaches that pave the way for a direct use of inclusion bodies in biotechnological and medical applications. Protein Aggregation in Bacteria covers: * Molecular and cellular mechanisms of protein folding, aggregation, and disaggregation in bacteria * Physiological importance and consequences of aggregation for the bacterial cell * Factors inherent to the protein sequence responsible for aggregation and evolutionary mechanisms to keep proteins soluble * Structural properties of proteins expressed as soluble aggregates and as inclusion bodies within bacterial cells both from a methodological point of view and with regard to their similarity with amyloids * Control of the structural and functional properties of aggregated proteins and use thereof in biotechnology and medicine Protein Aggregation in Bacteria is ideal for researchers in protein science, biochemistry, bioengineering, biophysics, microbiology, medicine, and biotechnology, particularly if they are related with the production of recombinant proteins and pharmaceutical science.

Hepatobiliary cancer refers to primary malignant tumors originating in cells of the liver, bile ducts, and gallbladder. Globally, primary liver cancer, which includes hepatocellular carcinoma (~75 % of all cases) and intrahepatic biliary cancer or cholangiocarcinoma (~10-15 % 0f all cases) is the 6th most commonly diagnosed cancer and 3rd leading cause of cancer deaths worldwide. The vast majority of these highly malignant cancers are diagnosed at an advanced stage where treatment options are limited and patient survival outcomes are poor. The biological and therapeutic challenges posed by hepatobililiary cancers such as hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) are daunting, emphasizing a critical need to review and assess current and evolving basic, translational, and clinical research focused on addressing the critical obstacles that continue to limit progress towards achieving significant improvements in HCC and CCA clinical management and patient survival outcomes. Towards this goal, this special edition of Advances in Cancer Research is focused on providing a comprehensive, timely and authoritative reviews covering such topics of significant scientific and clinical relevance, including hepatobiliary cancer risk mechanisms and risk-predictive molecular biomarkers; causes and functional intricacies of inter- and intratumor heterogeneity; novel insights into the role of tumor microenvironment and key signaling pathways in promoting hepatobiliary cancer progression, therapeutic resistance and immunosuppression; emerging biomarkers of HCC and CCA prognosis; advances in molecular genomics for personalizing tumor classification and targeted therapies; innovative preclinical cell culture modeling for hepatobiliary cancer drug discovery; and current and emerging trends in hepatobiliary cancer molecular therapeutic targeting and immunotherapies.

Advances in Applied Microbiology, Volume 113, continues the comprehensive reach of this widely read and authoritative review source in microbiology. Users will find invaluable references and information on a variety of areas relating to the topic, with this release focusing on Gaps in the Assortment of Rapid Assays for Microorganisms of Interest to the Dairy Industry, Metal reduction and corrosion by bacterial biofilms, The microbiology of red brines, Clostridium thermocellum: a microbial platform for high-value chemical production from lignocellulose, and The zincophore system in pathogenic yeasts.

Management of Concentrate from Desalination Plants provides an overview of the alternatives for managing concentrate generated by brackish water and seawater desalination plants, as well as site-specific factors involved in the selection of the most viable alternative for a given project, and the environmental permitting requirements and studies associated with their implementation. The book focuses on widely used alternatives for disposal of concentrate, including discharge to surface water bodies; disposal to the wastewater collection system; deep well injection; land application; evaporation; and zero liquid discharge. Direct discharge through new outfall; discharge through existing wastewater treatment plant outfall; and co-disposal with the cooling water of existing coastal power plant are thoroughly described, and design guidance for the use of these concentrate disposal alternatives is presented with engineers and practitioners in the field of desalination in mind. Key advantages, disadvantages, environmental impact issues, and possible solutions are presented for each discharge alternative. Easy-to-use graphs depicting construction costs as a function of concentrate flow rate are provided for all key concentrate management alternatives.

Antimicrobial Resistance in Wastewater Treatment Processes Antimicrobial resistance is arguably the greatest threat to worldwide human health. This book evaluates the roles of human water use, treatment and conservation in the development and spread of antimicrobial resistance. Designed as a companion volume to Antimicrobial Resistance in the Environment (Wiley-Blackwell, 2012), this book is a multi-disciplinary synthesis of topics related to antimicrobial resistance and wastewater treatment processes. Antimicrobial Resistance in Wastewater Treatment Processes assembles detailed discussions written by many of the world s best-known experts in microbiology, civil engineering, chemistry, environmental science, public health and related fields. The book presents a collection of subjects that includes: * Current knowledge of the role of the environment in development and spread of antimicrobial resistance * Chemical analysis of antibiotics in environmental samples * Molecular methods for analysis of antimicrobial resistance genes * Advanced wastewater treatment processes and antimicrobial resistance effects * Public perception of risk related to health consequences of antimicrobial resistance * Public health implications of antimicrobial resistance with focus on wastewater treatment processes Antimicrobial resistance has gained a foothold in the global consciousness as a serious public health threat. There is a much greater appreciation for the role of the environment in the dissemination of antimicrobial resistance and the effects of pollutants that can potentially promote development of resistance in bacteria. Contaminants released from wastewater treatment plants are a concern. In Antimicrobial Resistance in Wastewater Treatment Processes, readers will be guided through examinations of the current science related to this important health issue.

Advances in Cancer Research, Volume 148, the latest release in this ongoing, well-regarded serial, provides invaluable information on the exciting and fast-moving field of cancer research.

Very Short Introductions: Brilliant, Sharp, Inspiring The term 'microbiomes' encapsulates an important scientific breakthrough of recent years. This is the realization that humans, other animals, and plants harbour communities of microorganisms which are mostly beneficial but can occasionally cause or exacerbate disease. Our quickly developing understanding of microbiomes is being translated into novel microbial therapies for human disease and is contributing to sustainable practices in agriculture and food production. On the flipside, there is a growing concern that some claims for microbiomes, especially in relation to human health, far exceed the scientific data. This Very Short Introduction is an essential guide to the fast-moving discipline of microbiome science. It accessibly distills the key facts about our resident microbiomes, explains how and why our health and wellbeing depend on them, and provides readers with the fundamental knowledge they need to judge the reliability of claims about microbiome-based applications. ABOUT THE SERIES: The Very Short Introduction series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

Water is the most valuable resource for all human development. With increasing global population the demand for water increases whereas the sources of clean water are decreasing. recycling and reuse of wastewater has become an imperative which demands the development of new, efficient and environmentally friendly treatment methods. Current Trends and Future Developments in (Bio-) Membranes: Recent Achievements in Wastewater and Water Treatments provides a comprehensive coverage of the existing wastewater treatment including, but not exclusively, membrane-based methods. The book presents most common used methods compares and evaluates them depending on their particular application. It illustrates many aspects of the various treatment systems used in water and wastewater purification and lists the advantages of membrane-based methods to non-membrane based technologies. This book focuses on introducing, applications, advantages/disadvantages, evaluating of membrane-based technologies and comparing it with other non-membrane based systems. It also analyses the various limitations of each method. Hence, the book is a key reference text for R&D managers in industry interested in the development of water/waste treatment technologies as well as academic researchers and postgraduate students working in the wider area of the strategic treatment, separation and purification processes.

This is the second of three volumes of "Keys to the Trematoda," a series on the systematics and identification of the Class Trematoda. The book presents the taxa in the Order "Echinostomida" and some of those in the Order "Plagiorchiida," with keys for their identification at the superfamily, family, subfamily and generic levels. The keys are based on critical examination of specimens by subject experts, and generic diagnoses are accompanied by illustrations of important morphological characters. This volume includes seven echinostomidan superfamilies (the echinostomatoids, haploporoids, haplosplanchnoids, heronimoids, microscaphidioids, paramphistomatoids and pronocephaloids) and two plagiorchiidan superfamilies (the allocreadioids and lepocreadioids). The first volume covered the Subclass "Aspidogastrea" and Order "Strigeida," while the third volume, due to be published in early 2006, will cover the remaining members of the Plagiorchiida.

Advances in Virus Research serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Microbial Products: Applications and Translational Trends offers complete coverage of the production of microbial products, including biopolymers, biofuels, bioactive compounds, and their applications in fields such as bioremediation, agriculture, medicine, and other industrial settings. This book focuses on multiple processes including upstream procedures and downstream processing, and the tools required for their production. Lab-scale development processes may not be as efficient when aiming for large-scale industrial production, so it is necessary to utilize in silico modeling tools for bioprocess design to ensure success at translational levels. Therefore, this book presents in silico and mathematical simulations and approaches used for such applications. Further, it examines microbial products produced from bacteria, fungi, and algae. These major microbial categories have the capacity to produce various, diverse secondary metabolites, bioactive compounds, enzymes, biopolymers, biofuels, probiotics, and more. The bioproducts examined in the book are of great social, medical, and agricultural benefit, and include examples of biodegradable polymers, biofuels, biofertilizers, and drug delivery agents. Presents approaches and tools that aid in the design of eco-friendly, efficient, and economic bioprocesses. Utilizes in silico and mathematical simulations for optimal bioprocess design. Examines approaches to be used for bioproducts from the lab scale to widely applied microbial biotechnologies. Presents the latest trends and technologies in the production approaches for microbial bio-products manufacture and application. This book is ideal for both researchers and academics, as it provides up-to-date knowledge of applied microbial biotechnology approaches for bio-products.

Advances in Applied Microbiology, Volume 123 continues the comprehensive reach of this widely read and authoritative review source in microbiology. Users will find invaluable references and information on a variety of areas relating to the topics of microbiology.

Epigenetic Regulation of Cancer in Response to Chemotherapy, Volume 158 of the Advances in Cancer Research series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Lyme borreliosi, s commonly known as lyme disease, is now acknowledged as the most highly prevalent arthropod-borne human disease in northern temperate regions of the world. This book describes the basic characteristics of the disease, the biology of the pathogens in their vectors and vertebrate hosts, their ecology in different regions of the world and the global epidemiology of the disease. The final chapters address the prevention and control measures that have resulted from this knowledge

Bioengineered Nanomaterials for Wound Healing and Infection Control is a key reference for those working in the fields of materials science, pharmacy, nanotechnology, biomedical engineering and microbiology. Bioengineered nanomaterials have unique physicochemical properties which promote accelerated wound healing and treatment of infections. The biosynthesis of these nanomaterials also offers a clean, safe and renewable alternative to traditional nanomaterials, helping reduce environmental impact alongside antibacterial resistance.

In 2020 we lost Noel Rose, co-editor of the classic Infection and Autoimmunity. To honor and respect his work, a group of experts in the field have taken the initiative to make this book perpetual. The third edition of Infection and Autoimmunity updates all the recent and leading papers on infection and autoimmunity, in addition to a dedicated section on to the correlation between SARS-CoV-2 infection and autoimmunity. From the very beginning of the COVID-19 pandemic, numerous papers have been published, including studies conducted by the editors and authors of the book, on COVID-19 and autoimmunity, and therefore this knowledge has been incorporated into this new edition. The addition and extended coverage on SARS-CoV-2/COVID-19 and autoimmunity are pivotal for the third edition of the book due to the COVID-19 pandemic. Medical students and practitioners, as well as academic staff in medical schools globally, are enthusiastic in searching for better understanding of the correlation between infection and autoimmunity in general, and the long-term effects of SARS-CoV-2 and COVID-19 on the immunce system in particular, especially in terms of autoimmunity related to the virus.

The aim of this new book series (Diatoms: Biology and Applications) is to provide a comprehensive and reliable source of information on diatom biology and applications. The first book of the series, Diatoms Fundamentals & Applications, is wide ranging, starting with the contributions of amateurs and the beauty of diatoms, to details of how their shells are made, how they bend light to their advantage and ours, and major aspects of their biochemistry (photosynthesis and iron metabolism). The book then delves into the ecology of diatoms living in a wide range of habitats, and look at those few that can kill or harm us. The book concludes with a wide range of applications of diatoms, in forensics, manufacturing, medicine, biofuel and agriculture. The contributors are leading international experts on diatoms. This book is for a wide audience researchers, academics, students, and teachers of biology and related disciplines, written to both act as an introduction to diatoms and to present some of the most advanced research on them.