Age Estimation: A Multidisciplinary Approach is the only reference in the field covering all techniques and methods involving age estimation from different perspectives in just one volume. The book provides comprehensive coverage of all aspects of age estimation: aging the living and the dead, human rights, and skeletal, dental, histological and biochemical techniques and methods available. Each chapter is written by internationally known expert contributors. Age Estimation: A Multidisciplinary Approach is a one of a kind resource for those involved in estimating the age of the living and the dead.

This volume explores experimental approaches used to study Duchenne muscular dystrophy (DMD), an X-linked degenerative skeletal muscle disease caused by mutations in the dystrophin gene. Including the latest progress and scientific achievements, the book covers recent discoveries achieved through in vivo gene editing which have proven to be promising in restoring dystrophin expression, at least in ameliorating skeletal muscle symptoms, and the contents focus on "Omics" techniques in gene expression, protein expression, miRNAs, and long non-coding RNA analysis, as well as experimental studies of the structural/functional changes affecting the skeletal and cardiac muscles and ongoing preclinical studies and clinical trials. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Duchenne Muscular Dystrophy: Methods and Protocols serves as a guide for researchers exploring the complicated nature of dystrophin in the hope of helping the victims of this disorder.

Cardioskeletal Myopathies in Children and Young Adults focuses on plaques that kill people in their 40's-50's and the way they start to form in young adulthood. The Annals of Family Medicine report that approximately half of young adults have at least one cardiovascular disease risk factor (Mar 2010), and an increase in cardiovascular mortality rates in young adults was substantiated in a study at Northwestern Medicine (Nov 2011). Given the increasing recognition of genetic triggers behind all types of cardiovascular disease, and the growing population of young adults with primary or acquired myocardial disease, the need has arisen for a reference that offers a comprehensive approach to the understanding of basic, translational, and clinical aspects of specific muscle diseases while making the link between young adult and adult health.

Spinal Muscular Atrophy: Disease Mechanisms and Therapy provides the latest information on a condition that is characterized by motoneuron loss and muscle atrophy, and is the leading genetic cause of infant mortality. Since the identification of the gene responsible for SMA in 1995, there have been important advances in the basic understanding of disease mechanisms, and in therapeutic development. This book provides a comprehensive accounting of recent advances in basic and clinical research that covers SMA clinical features and standards of care, multifaceted aspects of SMN protein functions and SMA disease pathology, various animal models, and biomarkers, as well as current therapeutic development. This title is ideal for graduate students/postdocs and principal investigators who are already in the SMA field and need to keep updated on recent findings and approaches, and for those who are new to, or would like to join, the field. Likewise, users will find an excellent source of reading for biotech/pharma scientists, clinical researchers, and practitioners, regulators, and patients and their advocacy organizations. Furthermore, this book is a handy reference for researchers and clinicians who may want to apply the research strategies and therapeutic approaches in SMA to other rare diseases.

Covering everything from recognising symptoms and obtaining initial diagnosis to living with the condition on a daily basis, this complete guide to living with and managing Ehlers-Danlos Syndrome (Hypermobility Type - formerly known as Type III) has been revised and fully-updated in this accessible new edition. The author, who has the condition, looks at how it affects children and adolescents and explores pain management, pregnancy, physical and psychological aspects, and how it widely affects dancers and other performance artists. New material includes: changes in terminology information on how osteopathy and nutrition can help psychological approaches beyond CBT how to deal with professionals what to expect from support groups and rehabilitation programmes This new edition will be a must for anybody who suffers, or suspects they might be suffering from, Ehlers-Danlos Syndrome (Hypermobility Type) and provides everything needed to enjoy a fulfilling life with this complex condition. It will also be of interest to their families and friends, and professionals working with Hypermobility Type EDS.

Covering the entire spectrum of this fast-changing field, Diagnostic Imaging: Musculoskeletal Non-Traumatic Disease, third edition, is an invaluable resource for musculoskeletal radiologists, general radiologists, and trainees-anyone who requires an easily accessible, highly visual reference in this complex area of imaging. Drs. Kirkland W. Davis, Donna G. Blankenbaker, Stephanie A. Bernard, and their team of highly regarded experts provide up-to-date information on recent advances in technology and the understanding of musculoskeletal diseases and disorders to help you make informed decisions at the point of care. The text is lavishly illustrated, delineated, and referenced, making it a useful learning tool as well as a handy reference for daily practice. Guides readers through the complexities of the full range of non-traumatic musculoskeletal disorders, including arthritis, collagen vascular diseases, bone tumors, soft tissue tumors, infections, systemic diseases, developmental and congenital abnormalities, and metabolic diseases Contains multiple new chapters on topics such as musculoskeletal genetics, neurinomas, and rapidly progressive osteoarthritis, among others, as well as updates throughout on reclassified lesions, tumors, and neoplasms; musculoskeletal infection details, including image-guided aspirations and biopsies for infections; and evolving medical and surgical treatments for many musculoskeletal conditions Reflects recent changes in the World Health Organization's classification of tumors and tumor-like conditions regarding terminology and diagnostic criteria Covers evolving imaging techniques such as ultrasound in non-traumatic disease imaging, contrast-enhanced ultrasound use in tumor biopsies, enhanced MR of musculoskeletal tumors, and diffusion-weighted MR, and PET/CT and PET/MR use for rapidly progressive osteoarthritis Provides up-to-date discussions of enhancements in bone and soft tissue tumor pathology and imaging of orthopedic implants and related hardware Features more than 3,750 annotated images (with an additional 2,100+ digital-only examples), including radiologic images, full-color medical illustrations, clinical and histologic photographs, and gross pathology images Uses bulleted, succinct text and highly templated chapters for quick comprehension of essential information at the point of care

Logically organized with comprehensive coverage, this newly revised third edition prepares you to choose the right orthopedic tests, accurately assess any patient, and arrive at a clear diagnosis. Trusted for both its depth of coverage and its accessible, accurate information, it features gamuts, clinical pearls, and cross-reference tables for quick and easy reference. Now in brilliant full color, with all new photos of every test, it's even more visually appealing, and illustrates common conditions and procedural tests more effectively than ever before. This edition offers a fresh look at testing for orthopedic conditions, with detailed text that explains the key moves of each test, its alternate names, and the appropriate reporting statement. Extensive cross-referencing ensures that you can easily find the right test for efficient and effective practice, and protocol charts guide you through the examination process step by step. The companion DVD features video footage of Dr. Evans performing each assessment test in the book, along with his expert commentary. Chapters are logically organized by region, and tests within each chapter are arranged alphabetically, so you can find the information you need in seconds! Each test begins with a brief discussion of basic anatomy, then moves into a description of the actual procedure and ends with next-step directives. Critical Thinking questions at the end of each chapter help you apply what you've learned to clinical practice. Orthopedic Gamuts provide summaries of key points in a concise list - numerous gamuts within each chapter help you master material quickly and easily. Clinical Pearls share the author's knowledge gained through years of clinical experience, helping you avoid common misdiagnoses. Cross-reference tables offer at-a-glance guidance on which tests should be used to diagnose particular diseases, for maximum accuracy and efficiency in practice. Each chapter begins with an index of tests for easy reference, and axioms that remind you of elemental information, such as how painful certain maneuvers may be or the extent of some body parts' range. Contains a chapter on malingering (non-organically-based complaints), helping you investigate and determine the root cause of complaint, whether due to injury, for psychological reasons, or an attempt to feign injury for various purposes, such as for improper receipt of worker's compensation. Companion DVD contains video footage of Dr. Evans performing and explaining each assessment test in the book. Full-color photographs demonstrate how to perform 237 orthopedic tests! At the Viewbox feature contains high-quality radiographs that depict various pathologies, as well as musculature and other anatomy that can't be shown photographically.

In the diagnosis and treatment of movement disorders, the use of neuroimaging has expanded widely and has been an exciting, important modality for unlocking the causes of abnormal motor control. With ever improving machinery, data collection techniques and analysis methods, researchers are now being presented with an exponentially increasing amount of data that they must wade through and interpret in the context of existing knowledge about movement disorders.

In "Neuroimaging in Movement Disorders, " the editors have produced a gold-standard resource that brings together an impressive international group of authorities in their respective fields to outline the current state of knowledge. Controversies, such as conflicting findings and methodological limitations, are covered and provide the reader with a comprehensive yet pragmatic understanding of the state of science. The chapters offer both comprehensive reviews of various neuroimaging methods and also more in-depth summaries of the contributions made by neuroimaging in individual movement disorders. Although many of the neuroimaging methods that are discussed have not been routinely used in clinical practice, the authors skillfully provide the reader with adequate detail to understand the requirements for using these methods and in some cases even the starting knowledge to begin local implementation. "Neuroimaging in Movement Disorders" is an indispensable reference that will be of value to all physicians and researchers involved in the care of patients with movement disorders.

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Fully updated in a new, contemporary edition - the bestselling guide to cider vinegar, and its role in reducing pain and improving mobility.

Hundreds of thousands of people with arthritis have been helped by the Margaret Hills Clinic and by Margaret's bestselling book, Treating Arthritis: The Drug-free Way. Cider vinegar is a cornerstone of the treatment protocol, and this companion title has been completely updated with all-new recipes featuring this amazing natural product, in addition to suggesting a wide variety of other uses, all of which can help to reduce arthritic pain and joint stiffness.

Embracing the simple principles that make this drug-free protocol so effective, this book will help you to make cider vinegar a regular part of your daily diet, and offer insight into just why it is so effective. In addition to reducing inflammation and improving mobility, cider vinegar can aid with weight loss - it can also replace many of the chemically-derived products in your home, or in your personal care routine, making your environment a healthier and potentially much less toxic one.

The very many recipes in this book all feature the wonder ingredient that is cider vinegar, and they all cater for vegetarians and vegans. There are recommendations for those managing auto-immune conditions such as coeliac disease, or food allergies, and the emphasis throughout is on fresh, raw, local ingredients.

Cider Vinegar complements Margaret Hills' renowned Treating Arthritis programme to offer gentle, natural and manageable steps to reduce pain and improve mobility.

This issue of Foot and Ankle Clinics, guest-edited by Drs. Jorge Filippi and German Joannas, will discuss Controversies in Acute Trauma and Reconstruction. This issue is one of four selected each year by long-time series Consulting Editor, Dr. Mark Myerson. Topics in this issue will include: Induced Membrane technique (Masquelet) for Bone Defects in the Distal Tibia; New principles in pilon fracture management; High energy pilon fractures; Strategies to avoid syndesmosis malreduction in ankle fractures; Complex Ankle Fractures; Acute deltoid ligament repair in ankle fractures; Chronic syndesmotic injuries: arthrodesis vs reconstruction; Talar neck fractures; Sinus tarsi approach for calcaneal fractures; Fixation by ORIF or primary arthrodesis of calcaneus fractures; How to identify unstable Lisfranc injuries; Subtle Lisfranc injuries; Primary arthrodesis for high energy Lisfranc injuries; and Jones fracture in the non-athletic population.

This issue of Hand Clinics, guest edited by Dr. Julie E. Adams, will cover a number of essential topics surrounding Managing Axial Instability of the Forearm. This issue is one of four issues selected each year by series Consulting Editor, Dr. Kevin Chung. Topics in this issue will include: Problems of Eponymous Proportions: the history of our recognition of forearm instability issues, Biomechanical factors in stability of the forearm, Chronic Distal Radiolunar instability, Acute distal radioulnar joint instability, Galeazzi injuries, Essex Lopresti - evaluation and treatment considerations, Management of Monteggia Injuries in the Pediatric Patient, Management of Moteggia Injuries in the Adult, Elbow instability: evaluation and Treatment, Elbow fracture dislocations, Rehabilitation of the unstable elbow, Solutions for the unstable and arthritic distal radioulnar joint, and Solutions for the unstable and arthritic elbow joint, among others.

This issue of Foot and Ankle Clinics, guest edited by Dr. Anthony Perera, will discuss Advances in Minimally Invasive Foot and Ankle Surgery. This issue is one of four selected each year by long time series Consulting Editor, Dr. Mark Myerson. Topics in this issue will include: Percutaneous lateral release and MIS HV; Biomechanical issues with MICA fixation and the development of intrameduallry fixation; Complications of MIS HV and how to deal with them; Bunionette; The windswept foot and dealing with metatarsus adductus and toe valgus; MIS osteotomies for diabetic foot disease; MIS flatfoot correction; MIS lesser toes; Endoscopic surgery for tarsal coalition; and Minimally invasive Lapidus, among others.

Offering a thorough, highly illustrated review of the musculoskeletal physical exam, this practical guide covers relevant anatomy, pathoanatomy, and special tests using the well-known art of Dr. Frank H. Netter as well as clinical photographs. Netter's Orthopaedic Clinical Examination: An Evidence-Based Approach, 4th Edition, provides the information you need to assess the reliability and diagnostic utility of musculoskeletal physical exams and incorporate evidence into your clinical decision making. Summary tables and carefully selected references highlight best available evidence, providing a practical resource for the busy student and clinician. Provides up-to-date, actionable summaries of available evidence so you can quickly evaluate the effectiveness of clinical tests, review recent studies, and determine which test will best predict a specific diagnosis. Includes more than 25 videos showing movement for select tests, helping you get the most clinically significant information from the orthopaedic examination. Presents classic Netter artwork and anatomy/biomechanics tables that enhance your understanding of the orthopedic anatomy and pathology of each joint. Uses a practical, tabular format that provides quick access to test reliability and diagnostic utility, study quality, anatomy and biomechanics, and summary recommendations for applying evidence in practice. Features an assessment of study quality (QUADAS) appendix and color-coded icons identifying study quality that draw your attention to top-quality studies and help you understand why some studies were included and others omitted. Adds a scale to reliability tables, making it easy to focus on approaches and tests with the highest reliability, and includes QAREL (Quality Appraisal for Reliability Studies) checklists for each reliability study. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

This edition of the companion volumes Muscle Pain: Understanding the Mech- isms and Muscle Pain: Diagnosis and Treatment is essential reading for those interested in clinical approaches to acute and chronic pain conditions involving muscle tissues and in the mechanisms underlying these conditions. The volumes cover a very important topic in pain medicine, since muscle pain is very common and can often be dif?cult to diagnose and treat effectively. Furthermore, chronic pain involving muscle and other components of the musculoskeletal system increases with age, such that it is a common complaint of those of us who are middle-aged or older. Indeed, as changing population demographics in "west- nized" countries result in higher proportions of the population living longer and being middle-aged and elderly, chronic muscle pain will likely become even more of a health problem. In the case of acute muscle pain, this can often be very intense, and in the short term can limit or modify the use of components of the musculoskeletal system associated with the sensitive muscle. Chronic muscle pain can also be intense, as well as unpleasant and disabling, and it is in many cases the over-riding symptom of most musculoskeletal disorders that are associated with long-term deleterious changes in musculoskeletal function.

This volume of Orthopedic Clinics will focus on Global Perspectives in Orthopedic Surgery. Edited by members of a distinguished board from the Campbell Clinic, including Dr. Frederick Azar as editor-in-chief, each issue features several articles from the key subspecialty areas of knee and hip, hand and wrist, shoulder and elbow, foot and ankle, pediatrics, and trauma. Topics discussed in the issue will include but are not limited to: Polio, POSNA-COUR Scholarship Program: Results of the First 15 Years, Delivery of Pediatric Orthopedic Care in Ecuador through Project Perfect World: Past, Present, and Future, The Burden of Disease Worldwide, Ulnar abutment syndrome in the athlete, Conservative and Surgical Treatment of Foot & Ankle Pathology Associated with Leprosy, and Brazilian Total Ankle Experience.

This issue of Hand Clinics, guest edited by Drs. Sandeep Sebastin and David Tan, will cover key topics of importance for Soft Tissue Reconstruction for Digital Defects. This issue is one of four selected each year by our series consulting editor, Dr. Kevin Chung. Topics discussed in this issue will include: Vascular Anatomy of the Hand in relation to flaps, Adipofascial Flaps, Transposition and Rotation Flaps, Antegrade Flow Digital Artery Flaps, Retrograde Flow Digital Artery Flaps, Flaps based on Palmar Vessels, Dorsal Metacarpal Artery based Flaps, Digital Artery Perforator based Flaps, Free Flaps and Venous Flaps for Digital Reconstruction, Soft Tissue Coverage of the Digits and Hand, and a Metanalysis of the Complications of Hand Flaps, among others.

This issue of Hand Clinics, guest edited by John Fowler and Richard J. Tosti, will cover a number of essential topic pertaining to Hand Infections. This issue is one of four issues selected each year by series Consulting Editor, Dr. Kevin Chung. Topics in this issue will include: Epidemiology and Public Health Burden of Hand Infections; Imaging/Lab work-up for Hand Infections; Antibiotic Management and Antibiotic Resistance; Hand Abscesses (Volar and Dorsal); Fingertip Infections (Felon/Paronychia); Flexor Tenosynovitis; Septic Joints (Finger and Wrist); Necrotizing Soft Tissue Infections in the Upper Extremity; Fungal Infections (including nail); Complications of Hand Infections; Soft Tissue Coverage for Severe Infections; Pediatric Hand Infections, among others.

This issue of Foot and Ankle Clinics, guest edited by Dr. Sudheer Reddy, will discuss Current controversies in the approach to complex hallux valgus deformity correction. This issue is one of four selected each year by long time series Consulting Editor, Dr. Mark Myerson. Topics in this issue will include: Hypermobility in Hallux Valgus; Cost-effectiveness of Surgical Techniques in Hallux Valgus; Current trends in anesthesia management in hallux valgus; Management of Hallux Valgus in Metatarsus Adductus; Role of coronal plane malalignment in hallux valgus correction; Evolution of MIS in hallux valgus; Current trends in fixation techniques; The evolution of thinking of fixation in the Lapidus procedure; Intraoperative and Postoperative evaluation of Hallux Valgus Correction; Postoperative Management of Hallux Valgus; Management of Complications; And Management of complications Arthritis of MTP joint Malunion/Nonunion.

Neuromuscular imaging has increasingly become an important tool in the detection and diagnosis of inherited and acquired neuromuscular disease. This book is a groundbreaking radiological and neurological overview of current methods and applications of imaging-including aspects of neuroimaging and musculoskeletal imaging-in patients with inherited, metabolic, and inflammatory muscle diseases. Imaging features are discussed in the context of clincial presentation, histopathology, therapeutic options and differential diagnosis. World leading expert contributors give a comprehensive and didactic review of neuromuscular disorders and available imaging modalities, each illustrated with numerous figures. Topics discussed include: -Modalities such as ultrasound, CT and MRI -Muscle anatomy and physiology -Clinical applications in hereditary and acquired myopathies -Clinical applications in motor neuron disorders and peripheral nerve imaging

This issue of Neuroimaging Clinics of North America focuses on Temporal Bone Imaging: Clinicoradiologic and Surgical Considerations, and is edited by Drs. Gul Moonis and Amy Fan-Yee Juliano. Articles will include: Imaging of Temporal Bone Infection Inflammation; Imaging of Meniere's Disease; Treatment of Vestibular Schwannoma; Post Operative Imaging of the Temporal Bone; Otosclerosis and Dysplasias of the Temporal Bone; Imaging of Syndromes with Temporal Bone Abnormalities; Imaging of Third Window Lesions; Imaging of Tinnitus; Imaging of Temporal Bone Tumors; Imaging of Pediatric Hearing Loss; Common Otologic Surgical Procedures: Clinical Decision Making Pearls; Imaging of Temporal Bone Trauma: A Clinicoradiologic Perspective; and more!

Basic and Applied Bone Biology, Second Edition, provides an overview of skeletal biology, from the molecular level, to the organ level, including cellular control, interaction and response, adaptive responses to various external stimuli, and the interaction of the skeletal system with other metabolic processes in the body. The book includes chapters that address how the skeleton can be evaluated through the use of various imaging technologies, biomechanical testing, histomorphometric analysis, and the use of genetically-modified animal models. Each chapter delves deep into the important details of topics covered to provide a solid understanding of the basics of bone biology. Bone biology researchers who also train undergraduate and graduate students in the lab will use this book constantly to orient new students on the basics of the field and as a background reference for many of the technical aspects of qualification in bone biology (e.g., mechanics, histomorphometry, genetic modification, biochemistry, etc.).

Whether you call them work-related upper limb disorders (WRULDs), cumulative trauma disorders (CTDS), or occupational overuse syndromes (OOSs), these conditions are a cause of pain, disability and suffering to workers worldwide. These designations often imply that their causes are related to work, but the supporting evidence can be unclear. Transparency is important, especially when it is necessary to form a connection with work factors to obtain treatment or compensation. This book addresses the dilemma. Written by a professional ergonomist with almost 40 years of experience in workplace ergonomics, this book combines a critical summary and assessment of the epidemiological literature with an exploration of the scientific and medical evidence for possible causal mechanisms to develop well-informed conclusions on causation of a number of common musculoskeletal disorders of the upper limb and intervertebral disc injury. Although much of the book focuses on physical factors, the role of psychosocial factors is increasingly being recognized and an additional chapter reviews a number of the current theories relating to this important issue. Features Focuses on a clear and authoritative account of the evidence for the role of work in the causation of commonly occurring ULDs and disc injury Provides an up-to-date compilation of the scientific evidence, devoid of views based on assumptions or prejudice Presents a clear explanation of the most likely causal mechanisms for common ULDs and disc injuries Includes a summary of theories concerning the role played by psychosocial factors Outlines the statistical evidence in a clear and understandable manner Bridges the gap between the evidence-base in the scientific and medical research literature and the practitioner

Guest edited by Drs. Donald Lalonde and Jin Bo Tang, this issue of Hand Clinics will cover several key areas of interest related to Global Advances in Wide Awake Hand Surgery. This issue is one of four selected each year by our series Editor-in-Chief, Dr. Kevin Chung of University of Michigan. Articles in this issue include, but are not limited to: The Canadian model for instituting wide awake hand surgery; Latest advances in wide awake hand surgery; Wide awake surgery as an opportunity to enhance clinical research; Wide awake secondary tendon reconstruction; WALANT in South America; Wide awake hand surgery at in South Korea; Wide awake tendon transfers in leprosy patients in India; WALANT hand surgery in military healthcare delivery; Wide awake wrist and small joint arthroscopy of the hand; and the Impact of WALANT on departmental settings, cost, patient satisfaction and beyond