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Entropy-Enthalpy Compensation - Finding a Methodological Common Denominator through Probability, Statistics, and Physics (Hardcover)
Loot Price: R3,556
Discovery Miles 35 560
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Entropy-Enthalpy Compensation - Finding a Methodological Common Denominator through Probability, Statistics, and Physics (Hardcover)
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Professionals recognize entropy-enthalpy compensation as an
important factor in molecular recognition, lead design, water
networks, and protein engineering. It can be experimentally studied
by proper combinations of diverse spectroscopic approaches with
isothermal titration calorimetry and is clearly related to
molecular dynamics. So, how should we treat entropy-enthalpy
compensation? Is it a stubborn hindrance that solely complicates
the predictability of phenomena otherwise laid on the line by
Mother Nature? How should we then deal with it? This book dwells on
these posers. It combines two chapters written by globally
recognized specialists. Chapter 1 deals with general issues and
suggests a definite approach to how we may answer the posers.
Chapter 2 shows how the approach outlined might be successfully
applied in a rational design of enzymes. This might provide other
interesting strategic perspectives in the general theoretical
physical chemistry field.
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