This book summarizes the various microfluidic-based approaches for single-cell capture, isolation, manipulation, culture and observation, lysis, and analysis. Single-cell analysis reveals the heterogeneities in morphology, functions, composition, and genetic performance of seemingly identical cells, and advances in single-cell analysis can overcome the difficulties arising due to cell heterogeneity in the diagnostics for a targeted model of disease. This book provides a detailed review of the state-of-the-art techniques presenting the pros and cons of each of these methods. It also offers lessons learned and tips from front-line investigators to help researchers overcome bottlenecks in their own studies. Highlighting a number of techniques, such as microfluidic droplet techniques, combined microfluidics-mass-spectrometry systems, and nanochannel sampling, it describes in detail a new microfluidic chip-based live single-cell extractor (LSCE) developed in the editor's laboratory, which opens up new avenues to use open microfluidics in single-cell extraction, single-cell mass spectrometric analysis, single-cell adhesion analysis and subcellular operations. Serving as both an elementary introduction and advanced guidebook, this book interests and inspires scholars and students who are currently studying or wish to study microfluidics-based cell analysis methods.

Atomization and sprays are used in a wide range of industries: mechanical, chemical, aerospace, and civil engineering; material science and metallurgy; food; pharmaceutical, forestry, environmental protection; medicine; agriculture; meteorology and others. Some specific applications are spray combustion in furnaces, gas turbines and rockets, spray drying and cooling, air conditioning, powdered metallurgy, spray painting and coating, inhalation therapy, and many others. The Handbook of Atomization and Sprays will bring together the fundamental and applied material from all fields into one comprehensive source. Subject areas included in the reference are droplets, theoretical models and numerical simulations, phase Doppler particle analysis, applications, devices and more.

Describes the methodologies and best practices of the sterile manufacture of drug products Thoroughly trained personnel and carefully designed, operated, and maintained facilities and equipment are vital for the sterile manufacture of medicinal products using aseptic processing. Professionals in pharmaceutical and biopharmaceutical manufacturing facilities must have a clear understanding of current good manufacturing practice (cGMP) and preapproval inspection (PAI) requirements. Sterile Processing of Pharmaceutical Products: Engineering Practice, Validation, and Compliance in Regulated Environments provides up-to-date coverage of aseptic processing techniques and sterilization methods. Written by a recognized expert with more than 20 years of industry experience in aseptic manufacturing, this practical resource illustrates a comprehensive approach to sterile manufacturing engineering that can achieve drug manufacturing objectives and goals. Topics include sanitary piping and equipment, cleaning and manufacturing process validation, computerized automated systems, personal protective equipment (PPE), clean-in-place (CIP) systems, barriers and isolators, and guidelines for statistical procedure. Offering authoritative guidance on the key aspects of sterile manufacturing engineering, this volume: Covers fundamentals of aseptic techniques, quality by design, risk assessment and management, and operational requirements Addresses various regulations and guidelines instituted by the FDA, ISPE, EMA, MHRA, and ICH Provides techniques for systematic process optimization and good manufacturing practice Emphasizes the importance of attention to detail in process development and validation Features real-world examples highlighting different aspects of drug manufacturing Sterile Processing of Pharmaceutical Products: Engineering Practice, Validation, and Compliance in Regulated Environments is an indispensable reference and guide for all chemists, chemical engineers, pharmaceutical professionals and engineers, and other professionals working in pharmaceutical sciences and manufacturing.

Rotary Drum: Fluid Dynamics, Dimensioning Criteria, and Industrial Applications provides in-depth analysis of fluid dynamics in rotary drums. In addition, it provides analysis on the different configurations, including nonconventional ones, diverse industrial applications, and comparison with competing dryer types, as well as the modeling of these devices. Covering important aspects of fluid dynamics in rotary drums, which directly influence the drying performance, the book also considers the significant cost of conventional rotary dryers. It takes into account the scale-up of rotary dryers and the control of product quality during processing, which can leave the final product overdried and overheated, wasting thermal energy. The book serves as a useful reference for researchers, graduate students, and engineers in the field of drying technology.

Molecular and Colloidal Electro-Optics presents cohesive coverage from internationally recognized experts on new approaches and developments in both theoretical and experimental areas of electro-optic science. It comprises a well-integrated yet multi-disciplinary treatment of fundamental principles, strategies, and applications of electro-optic techniques for the characterization of macromolecular, small-particle, and nanomolecular systems. Following a historical review of post-war advances in electro-optics of disperse systems, the first part of the book focuses on the latest achievements in electro-optic theory, particularly low-frequency relaxation. It offers comparative discussions and experimental data to accompany different viewpoints on the origin of the low-frequency effects and multiple theoretical constructions. The second part highlights the unique advantage of using electro-optics as an alternative to conventional characterization and analysis of colloidal systems. Demonstrating the sensitivity of electro-optic methods to interparticle interactions, the book explains how these methods are used to analyze particle surface electric states, evaluate phase transitions, and determine physical properties. As the first treatment of this subject to surface in more than fifteen years, Molecular and Colloidal Electro-Optics is a definitive, up-to-date portrait of modern colloidal electro-optic science. This one-stop reference to the latest theory, methods, and applications is ideal for advanced graduate students and researchers in biophysical chemistry, microbiology, polymer, colloid, and nanoscience.

The construction industry is bombarded with ever-changing building materials-components of which are more and more difficult, if not impossible, to identify. Building material emissions have been implicated as a major source of indoor air pollution, and toxic gases, often unidentified, are generated in building fires. Building Materials: Product Emission and Combustion Health Hazards undertakes the task of identifying building materials emission and combustion health hazards. This practical guide introduces the complex world of polymers commonly used in building materials along with plasticizers and additives that are not regulated by OSHA. It also explores the topic of building materials as they relate to function and their emissions/combustion products along with thermal decomposition and combustion products as they relate to fire first responders. Engaging environmental professionals, construction management firms, architects, first respondents, and students, this valuable reference delivers a comprehensive spectrum of knowledge needed to face the challenges of managing building materials in the twenty-first century. Awareness is the first line of defense!

Based on the International Workshop on Controlled Life-Cycle of Polymeric Materials held in Stockholm, this work examines degradable polymers and the recycling of plastic materials. It highlights recent results on recycling and waste management, including topics such as renewable resources, degradation, processing and products, and environmental issues.

Thermodynamics is an indispensable tool for developing a large and growing fraction of new polymers and polymer blends. These two volumes show the researcher how thermodynamics can be used to rank polymer pairs in order of immiscibility, including the search for suitable chemical structure of compatibilizers. Because of the great current commercial interest in this most dynamic sector of the polymer industry, there is high interest in studying their physical and mechanical properties, their structures, and the processes of their formation and manufacture. These Books are dedicated to Analysis of the Thermodynamics of Polymer Blends. Thermodynamic behavior of blends determines the compatibility of the components, their morphological features, rheological behavior, and microphase structures. As a result, the most important physical and mechanical characteristics of blends can be identified.

This book covers myths about technology, management, toxicology, and the environment. It helps all who work in the chemical industry and all chemical engineers, including teachers and students to avoid accidents and wrong decisions and use resources more effectively.

This book provides an overview of the chemical and physical concepts of instability and incompatibility of petroleum and liquid fuels. It helps the petroleum refinery personnel to handle liquid fuels from other sources as feedstocks for the refinery system.

Hazardous Waste Risk Assessment provides a concise yet comprehensive examination of concepts and techniques in risk assessment that can be applied to hazardous waste problems. The book emphasizes the use of health risk assessment to support management decisions on hazardous waste disposal and site remediation programs. Methods discussed include those for developing strategies for health and environmental assessment and site restoration tasks, evaluating corrective action programs, determining the effects of risk assessment results on risk management decisions in hazardous waste programs and general risk management and prevention programs, and performing safety evaluations of hazardous waste facilities. Step-by-step numerical case evaluations are used to help present the book in an easy-to-follow, realistic manner. Features

A wide-ranging compilation of techniques, Extrapolation Practice for Ecotoxicological Effect Characterization of Chemicals describes methods of extrapolation in the framework of ecological risk assessment. The book, informally known as EXPECT, identifies data needs and situations where these extrapolations can be most usefully applied, making it a practical guide to the application of extrapolation procedures. It focuses on the extrapolation of chemical effects and covers the extrapolation of exposures in the context of interactions between toxicants and the matrix.

After a day's work is finished, take a look around at your company. Do standard production processes and day-to-day operations leave you with loaded trash bins from the front office to the factory floor-and every place inbetween? Such "solid waste" does far more than squander resources and imperil the environment... it's undoubtedly eating up countless dollars of your profits. Corporations throughout the nation are learning to tame solid waste, by implementing improved management of materials. Preventing Waste at the Source demonstrates how more than 50 companies have effectively reduced solid waste throughout all departments-and achieved dramatic reductions in operating costs. Beginning with a strategic framework, readers can then zero in on wasteful practices affecting all aspects of a business. Paper reduction measures for administrative offices, for instance. Ways to minimize packing materials over in the shipping department, while still protecting the product. There's also steps where suppliers and customers can take part in waste minimization efforts. Case histories prove it can be done, to everyone's advantage. Researched and compiled by the Indiana Institute on Recycling, Preventing Waste at the Source offers practical, on-the-job assistance to environmental managers, plant managers, manufacturing and quality engineers. Put its techniques and real-life guidance to work. You'll save more than money: you'll help save the environment.

This book 'Extremophiles: Wastewater and Algal Biorefinery' explores the potential of extremophiles/extremotolerant organisms in wastewater treatment, biorefining of algal biomass and in the treatment of industrial waste effluent. The book provides a holistic overview about the current status of extremophiles in waste water treatment and various industrial processes. The chapters comprehensively cover the scientific and research findings on various industrial applications of extremophiles such as biofuels, extremozymes, electricity generation, biofilms, microbial corrosion and waste water treatment etc. This book is an integrated source of literature for the scientists, engineers, academicians, and students working in the area of extremophiles, microbial technology and biorefinery.

Difficult to measure accurately and deal with effectively, organic pollutants continue to be a major hazard in the environment. Significantly expanded, the second edition of Organic Pollutants: An Ecotoxicological Perspective describes the mechanistic basis of ecotoxicology, using major groups of pollutants as illustrative examples, and explores the problem of complex mixtures of chemicals. New in the Second Edition: Expanded coverage of complex pollution problems and the exploitation of recent scientific and technological developments to investigate them New chapters: Endocrine Disrupting Chemicals and their Environmental Impacts and Neurotoxicity and Behavioral Effects Additional information on biomarker approaches and new technologies, such as microarrays assays, developed to address complex pollution problems Tried-and-True Format Presents Updated Information Keeping the same format that made the first edition so popular, the text begins with coverage of the basic principles underpinning the environmental behavior and effects of organic pollutants. It then describes the properties and ecotoxicology of major pollutants, discusses some issues that arise after consideration of the material in the second part of the text, and explores future prospects. Mechanistic Approach Provides Basis for Development of New Strategies The book takes a bottom up approach, describing the mechanisms by which pollutants have harmful effects on living organisms and how these effects are translated into adverse changes at the population level. This mechanistic approach supplies the basis for development of new mechanistic biomarker assays, which in turn provide measures of toxic effect and not merely of exposure, and subsequently provide evidence of causality between pollutant levels and ecological changes.

Drawing from the third edition of the bestselling Powder Technology Handbook, this book is focused solely on analyzing the fundamental properties and behavior of particles and particle beds. Powder Technology: Fundamentals of Particles, Powder Beds, and Particle Generation concentrates on the most useful analytical methods of observation, measurement, modeling, and prediction. This volume carefully incorporates the progressive work and vision of new authors while retaining the concepts that continue to promote innovative research and applications. The authors highlight new information and developments from areas including surface properties and analysis, particle motion in fluids, mechanical properties of a powder bed, and the design and formation of composite particles. They explain how particles deposit, coagulate, and settle in various media, explore different techniques for generating particles in different states, and detail methods of surface modification. Particularly useful for scientists studying nanoparticle applications, Powder Technology: Fundamentals of Particles, Powder Beds, and Particle Generation incorporates the latest developments in areas including surface properties and analysis, particle motion in fluids, mechanical properties of a powder bed, and the design and formation of composite particles.

Drawing from the third edition of the bestselling Powder Technology Handbook, this book concentrates on handling methods and unit operations for powder and particle processing techniques. Itexamines the purpose and factors involved in each process-including planning, equipment, measurements, and other necessary considerations. This book carefully incorporates the progressive work and vision of new authors while retaining the concepts that continue to promote innovative research and applications. In addition to detailing the purpose and implementation of processes including kneading, drying, filtration, and powder coating, the authors highlight recent developments in combustion and heating, electrostatic powder coating, and simulation. They also emphasize practical information including multipurpose equipment, instrumentation for key measurements, and modeling techniques. The text concludes with a review of recent data on the health effects of small particles and the types of protective devices that are currently available. Powder Technology: Handling and Operations, Process Instrumentation, and Working Hazards offers material scientists and chemical engineers a well-rounded guide to utilizing particle and powder processes for a rapidly expanding array of applications.

Presenting the only textbook available today that covers all of the critical elements of industrial hygiene o conceptual information, computational coverage, case studies, and sample problems and exercises o in one volume. Organized around the basic rubrics of industrial hygiene, this book helps students to think like industrial hygienists while offering the latest techniques for practicing professionals. Applications and Computational Elements of Industrial Hygiene is the most complete reference available on IH, and is also an ideal study aid for exam preparation. This is the first and only textbook that includes all critical computations for each concept covered. Each chapter discusses a different hazard and how to recognize, evaluate, and control it. The advantage of this approach is clear; technical issues, instrumental techniques, engineering control procedures o relevant issues from A to Z o are discussed for each hazard. Chapters conclude with case studies that offer critical insight into the practical aspects of the field. The book also covers emerging issues that will affect industrial hygienists in the future. The book includes real-life situations and experiences to demonstrate practical applications of concepts presented in the text. For students, Applications and Computational Elements of Industrial Hygiene offers critical material formerly scattered across multiple sources. For seasoned industrial hygienists, this is an essential problem-solving tool and state-of-the-art reference that consolidates and updates previously scattered information.

A reference for the chemical engineer on the application, selection, construction, procurement, installation, operation, and maintenance of the three basic types of pumps used in chemical processing: centrifugal, rotary, and reciprocating. Emphasizes aspects that cause practical operating problems,

Strong theoretical and practical knowledge of process control is essential for plant practicing engineers and operators. In addition being able to use control hardware and software appropriately, engineers must be able to select or write computer programs that interface the hardware and software required to run a plant effectively. Designed to help readers understand control software and strategies that mimic human activities, Fundamentals of Automatic Process Control provides an integrated introduction to the hardware and software of automatic control systems. Featured Topics Basic instruments, control systems, and symbolic representations Laplacian mathematics for applications in control systems Various disturbances and their effects on uncontrolled processes Feedback control loops and traditional PID controllers Laplacian analysis of control loops Tuning methods for PID controllers Advanced control systems Virtual laboratory software (included on downloadable resources) Modern plants require operators and engineers to have thorough knowledge of instrumentation hardware as well as good operating skills. This book explores the theoretical analysis of the process dynamics and control via a large number of problems and solutions spread throughout the text. This balanced presentation, coupled with coverage of traditional and advanced systems provides an understanding of industrial realities that prepares readers for the future evolution of industrial operations.

Polymer translocation occurs in many biological and biotechnological phenomena where electrically charged polymer molecules move through narrow spaces in crowded environments. Unraveling the rich phenomenology of polymer translocation requires a grasp of modern concepts of polymer physics and polyelectrolyte behavior. Polymer Translocation discusses universal features of polymer translocations and summarizes the key concepts of polyelectrolyte structures, electrolyte solutions, ionic flow, mobility of charged macromolecules, polymer capture by pores, and threading of macromolecules through pores. With approximately 150 illustrations and 850 equations, the book: Avoids heavy mathematics Uses examples to illustrate the richness of the phenomenon Introduces the entropic barrier idea behind polymer translocation Outlines conceptual components necessary for a molecular understanding of polymer translocation Provides mathematical formulas for the various quantities pertinent to polymer translocation The challenge in understanding the complex behavior of translocation of polyelectrolyte molecules arises from three long-range forces due to chain connectivity, electrostatic interactions, and hydrodynamic interactions. Polymer Translocation provides an overview of fundamentals, established experimental facts, and important concepts necessary to understand polymer translocation. Readers will gain detailed strategies for applying these concepts and formulas to the design of new experiments.

With the advent of polymer nanocomposites, research on polyolefin nanocomposites has grown exponentially. Correcting the deficiency of a meaningful text on these important materials, Advances in Polyolefin Nanocomposites: Sums up recent advances in nanoscale dispersion of filler in polyolefins Presents a basic introduction to polyolefin nanocomposite technology for the readers new to this field Provides insights on the use of technologies for polyolefins nanocomposites for commercial application Includes contributions from the most experienced researchers in the field Offers insights into the commercial usage of techniques The text uses theoretical models to illustrate the organic-inorganic interfaces in polyolefins and also provides a detailed description of the recently developed models for property prediction of these nanocomposites. It concentrates on developments with not only aluminosilicate fillers, but also with equally important fillers like layer double hydroxides and nanotubes. The authors review polyolefin nanocomposite technology and methodologies of generation, properties and generation of composite blends, and advances in synthesis of nanocomposites using solution blending methods. The book covers theoretical and experimental considerations of clay surface modification and the importance and effect of various prominent filler categories.

Derived from the fourth edition of the well-known Plastics Technology Handbook, Industrial Polymers, Specialty Polymers, and Their Applications covers a wide range of general and special types of polymers, along with a wealth of information about their applications. The book first focuses on commonly used industrial polymers, including polypropylenes, low- and high-density polyethylenes, and poly(vinyl chloride), as well as less widely used polymer types, such as acrylics, ether polymers, cellulosics, sulfide polymers, silicones, polysulfones, polyether ether ketones, and polybenzimidazoles. It then explores polymer derivatives and polymeric combinations that play special and often critical roles in diverse fields of human activities. The polymers covered include liquid crystal, electroactive, ionic, and shape memory polymers; hydrogels; and nanocomposites. The volume concludes with a comprehensive overview of new developments in the use of polymers in a variety of areas.

Until now, no comprehensive handbook on industrial biocatalysis has been available. Soliciting chapters on virtually every aspect of biocatalysis from international experts most actively researching the field, the Handbook of Industrial Biocatalysis fills this need. The handbook is divided into three sections based on types of substrates. The first section describes the newest biotechnology and bioprocesses for producing industrial products from hydrophobic substrates such as oils and fats. The discussion of biocatalysis covers single and multiple catalytic reactions involved in the creation of products as well as molecular manipulation of enzymes and product recovery. The products include healthy food, nutritional supplements, nutraceuticals, specialty chemicals, surfactants, biopolymers, and antimicrobial agents. The second section covers the production of value-added products from carbohydrate substrates. The scope of this section includes ethanol production, oligosaccharides and glycosides, utilization of hemicelluloses, and carbohydrate-active enzymes. The third section is dedicated to other potential industrial applications such as bioelectrocatalysis for synthesizing chemicals, fuels, and new drugs. The authors explore novel nutrition delivery systems, green chemistry, and the industrial applications of extremophiles. The organizer of several annual worldwide symposia on biocatalysis, editor Ching T. Hou has compiled a cornerstone reference for scientists in academic, industrial, and government research institutes, as well as for graduate-level students involved in biosciences, chemical engineering, biotechnology, microbiology, oil and colloid chemistry, and food chemistry.