"This work, featuring a reading level appropriate for high school audiences and above, is recommended for academic and public libraries." Library Journal

The Encyclopedia of Obesity is as much of a reference resource as it is a tool to raise awareness in the medical and public health communities. With almost 500 entries, these two volume summarize pertinent topics in obesity and related health conditions, including molecular biology, psychology, medicine, public health and policy, food science, environmental health, and pharmaceuticals. The editor has chosen topics that capture the current climate of obesity research while still addressing and defining the core concepts related to this condition. Based on a theme of Moving Forward in an Ever Expanding World articles address topics for a changing society that is slowly adapting to accommodate obesity, including recent lawsuits, new options for medical and dietary treatment, and the importance of prevention in children.

Key Themes

- Biological or Genetic Contributors to Obesity. Children and Obesity. Dietary Interventions to Treat Obesity. Disordered Eating and Obesity. Environmental Contributors to Obesity. Health Implications of Obesity. Medical Treatments for Obesity. New Research Frontiers on Obesity. Obesity and Behavior. Obesity and Ethnicity/Race. Obesity as a Public Health Crisis. Psychological Influences/Outcomes on Obesity. Societal Influences/Outcomes on Obesity. Women and Obesity. Worldwide Prevalence of Obesity

The Encyclopedia of Obesity is intended to serve as a general and nontechnical resource for biology, sociology, health studies, and other social science students, teachers, scholars, researchers, and anyone in the general public who wishes to understand the development of obesity as it prevails in the United States and worldwide.

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Fully revised for its third edition, the Oxford Handbook of Clinical Diagnosis provides a concise and practical summary of the reasoning processes behind clear and confident diagnosis. The handbook is set out systematically with symptoms and signs through each specialty, and includes a detailed description of the basis of logical evidence-based differential diagnosis. This new edition has been updated with more straightforward diagrams as well as brand new images to help aid understanding. Including rarer diagnoses alongside common conditions, and vital information about longer-term management alongside the initial treatments, this handbook will ensure your excellence and confidence no matter what signs and symptoms your patient presents with. Providing practical help when dealing with problems outside your area of expertise or with unforeseen situations, you can be sure that this handbook will be the reader's perfect companion to sharp and self-assured diagnoses throughout their medical career.

Bristol - 1953 It's Coronation Year. A new beginning in the aftermath of war, but there are still battles to be fought and secrets to be kept. Charlotte Hennessey-White copes with the shortcomings of her marriage and throws herself into helping refugees unwelcome by some and exploited by others. Edna Burbage has three beautiful children and considers herself lucky until the advent of a deadly twentieth century disease makes her think otherwise. Polly Chandler still hopes for a better life, but there are too many obstacles standing in her way. These three women lived through a war, can they now cope with the demands of peace? Praise for Lizzie Lane: 'A gripping saga and a storyline that will keep you hooked' Rosie Goodwin 'The Tobacco Girls is another heartwarming tale of love and friendship and a must-read for all saga fans.' Jean Fullerton 'Lizzie Lane opens the door to a past of factory girls, redolent with life-affirming friendship, drama, and choices that are as relevant today as they were then.' Catrin Collier 'If you want an exciting, authentic historical saga then look no further than Lizzie Lane.' Fenella J Miller

The Gunner Goggles Series is the first exam prep resource written by a high-scoring peer group of medical students, ensuring the most practical and efficient study guidance. It organizes topics around the USMLE and NBME content outlines for the required shelf exams and features state-of-the-art Augmented Reality (AR) mobile application to extend learning beyond the book. This innovative series features AR opportunities throughout the text for an integrated print-mobile experience that maximizes learning and test preparation. The Gunner Goggle function allows you to scan pages for integrated AR links, unlocking animations, visuals, and 3D models that clarify complex anatomy, conditions, and concepts in a remarkably effective and unique manner. Gunner Goggles Series: Medicine is one of seven authoritative exam preparation guides that use cutting-edge AR technology to fully prepare you for the NBME clinical shelf exams, the USMLE Step 2 Clinical Knowledge (CK) exam, and successful clinical rotations. Topics are organized around the USMLE and NBME content outlines for specific shelf exams, and information is presented in a highly templated, concise manner. The Augmented Reality application allows you to efficiently study and learn using an integrated print-mobile approach. In addition to unlocking animations and other visuals, AR app access also includes additional content, links to provide feedback to the authors, community pages, and more. All test topics are covered in just enough detail to help you hone in on key points you must know for exam success. Unique! Every disease is described by its stem clues (buzzwords that appear in question stems) and prophylactic measures (PPx), mechanism (MoD), diagnostic tests (Dx) and treatment/management principles (Tx/Mgmt) - the four "Physician Tasks" that the NBME requires students to know about each disease. You'll also get real-world tips for your clinical rotations from your peers - information that won't show up on the shelf exam but is ideal for maximum impact when on rounds (knowing the prognosis for a specific disease, for example). Plus . effective study techniques, sample study schedules, tips and tricks to better retain information learned from review questions, and methods to self-generate mnemonics. Edited, written, and crowdsourced by high-performing medical students and residents and reviewed by experts in the field to ensure accuracy, relevancy, and accessibility. Titles in the Gunner Goggles series: Family Medicine . Print ISBN: 978-0-323-51034-9 . e-Book ISBN: 978-0-323-52756-9 Medicine . Print ISBN: 978-0-323-51035-6 . e-Book ISBN: 978-0-323-52758-3 Neurology . Print ISBN: 978-0-323-51036-3 . e-Book ISBN: 978-0-323-52760-6 Ob-Gyn . Print ISBN: 978-0-323-51037-0 . e-Book ISBN: 978-0-323-52768-2 Pediatrics . Print ISBN: 978-0-323-51038-7 . e-Book ISBN: 978-0-323-52763-7 Psychiatry . Print ISBN: 978-0-323-51039-4 e-Book ISBN: 978-0-323-52765-1 Surgery . Print ISBN: 978-0-323-51040-0 . e-Book ISBN: 978-0-323-52767-5

It can be argued that ATP is the most important molecule in cells. Not only is ATP the key energy source for cells, but it is also the source of phosphate groups that are transferred to a variety of substrate proteins via the action of elaborate families of protein kinases. An equally elaborate array of protein phosphatases can remove phosphate groups from proteins. It is now well established that protein phosphorylation is a widely used mechanism for cells to selectively modulate the function of a variety of proteins including enzymes, ion channels and pumps and structural proteins. In this volume of ACAG leading experts describe the evidence that protein phosphorylation is altered in aging and age-related disease. Protein phosphorylation controls fundamental processes such as transcription and translation, regulation of the cell cycle, signalling within and between cells, cell motility, synaptic function and so on. Recent findings are revealing how phosphorylation dependent signalling cascades may control lifespan with a prime example being the insulin-signalling pathway first described in c-elegans and now emerging as an important regulator of lifespan of mammals also. Many of the functional changes that occur during aging such as impaired learning and memory and altered energy metabolism are controlled by protein phosphorylation and it is, therefore, important to understand how mechanisms of protein phosphorylation may either mediate aging or provide adaptive responses that allow successful disease-free aging. The authors in addition to considering the roles of protein phosphorylation in aging describe the evidence that abnormalities in protein phosphorylation contribute to the pathogenesis of major age-related diseases including diabetes, atherosclerosis and neurodegenerative disorders such as Alzheimer's and Parkinson's diseases.

This book summarizes recent advances in understanding the mechanism underlying the selective cell death of dopamine neurons in Parkinson's disease. MPTP, endogenous neurotoxins, L-DOPA, and metal were proved to induce apoptosis and necrosis in neurons. The relationship of these causal factors to the pathogenesis of Parkinson's disease was discussed to give us overviews on the role of neurotoxins in this degenerative disorder. This title further presents the intracellular signal transduction, and the related enzymes and other factors involved in dopaminergic neuronal death. Recent results on intracellular mechanism of neuroprotection are presented, suggesting that neuroprotection as a causal therapy of neurodegenerative disorders may become practical in near future. This book shows new neuroprotective agents, such as propargylamine derivatives and neurotrophins, and the intracellular mechanism to prevent the activation of apoptotic cascade in neurons. The authors of this book are active researchers participating in these subjects and the readers will find the knowledge and techniques for the study on neurotoxicity and neuroprotection, and the strategy for future research on these important subjects in clinical and basic neurology and neurosciences.

The book is dedicated to Professor Toshiharu Nagatsu, a pioneer in the search for pathogenic factors in Parkinson's disease. The book is reprinted from the journal 'Neurotoxicology and Teratology', Volume 24/5.

The U.S. Social Security Administration (SSA) administers the Social Security Disability Insurance program and the Supplemental Security Income program. As part of their process, immune system disorders are evaluated under Listing of Impairments 14.00 for adults and 114.00 for children. At the request of the SSA, the National Academies of Sciences, Engineering, and Medicine assembled a committee to review selected conditions related to the immune system. In particular, the SSA was interested in the current status of the diagnosis, treatment, and prognosis of immune system disorders including systemic lupus erythematosus (SLE), scleroderma, polymyositis, Sjoegren's syndrome/disease, and inflammatory arthritis. This report provides an overview of the current status of the diagnosis, treatment, and prognosis of these immune system disorders in the U.S. population and the relative levels of functional limitation typically associated with them, common treatments, and other considerations. Table of Contents Front Matter Summary 1 Introduction 2 Cross-Cutting Issues 3 Systemic Lupus Erythematosus 4 Scleroderma 5 Myositis 6 Inflammatory Arthritis 7 Sj?gren's Disease/Syndrome

This book reviews and examines the novel findings regarding anti-inflammatory effects of aerobic exercise. Furthermore, the authors discuss to what extend the exercise induced anti-inflammatory response may play a therapeutic role in chronic diseases associated with low-grade inflammation. Evidences for the anti-inflammatory healthy effects of regular continuous exercise are presented in this book.

In this book, an international group of investigators from a broad array of clinical and basic disciplines present the ideas and concepts in the foreground of cerebrovascular disease. Included in their discussion are perspectives on topics that continue to guide current investigations, such as white matter injury, newer imaging approaches, delayed neuronal death, and recovery after stroke, as well as continuing disagreements on the value of heparin or MRI endpoints in the management of stroke patients. Further topics include a proposal for a major multicenter re-study of the utility of extracranial-intracranial bypass surgery in light of additional diagnostic information available through PET scanning; examination of how processes such as apoptosis, inflammation, free radicals, poly (ADP-ribose) polymerase activation, and alterations in glutamate receptor function contribute to the pathogenesis of ischemic brain injury; and finally an exploration of how estrogens or cholesterol-lowering agents might be used therapeutically.

An intensive-care doctor reveals the long-term problems caused by ICUs, and how these can be prevented. Thousands of people are admitted to intensive-care units (ICUs) every day, and this is only increasing with the Covid-19 pandemic. Most of these admissions will be sudden, unexpected, and harrowing - an experience that can alter patients and their families in physical, emotional, and spiritual ways, with effects that endure for years. But there is hope. Dr Ely is a leading ICU doctor. His unconventional methods minimise patients being harmed by the cutting-edge technologies that are saving their lives; post-intensive care syndrome (PICS) is a well-established complication that millions of ICU survivors battle, which Dr Ely aims to eradicate. His cutting-edge studies have convinced doctors around the world to change their ICU practices for the better. Through captivating stories, Dr Ely shows how he and colleagues from around the world have re-introduced humanity into the ICU, creating pathways that bring hope and healing to healthcare. This is the future of medicine, and is a must-read for healthcare professionals, patients, and their families.

Volume 109 of "Current Topics in Developmental Biology" covers mouse models of the nuclear envelopathies and related diseases, with contributions from an international board of authors. The chapters provide a comprehensive set of reviews covering such topics as mouse models neurodegenerative diseases including Parkinson s and dystonia, muscle ageing and sarcopenia, cardiac failure and repair, ageing and prospects lifespan extension, lipodystrophy and the significance in fat regulation, also identifying developmental mutations in mammals and nuclear envelope and LINC complex in disease.
Covers the area of mouse models of developmental genetic diseaseInternational board of authors Provides a comprehensive set of reviews covering such topics as mouse models neurodegenerative diseases including Parkinson s, muscle aging, lipodystrophy, and more"

The aim of Volume 11 is to provide evidence on the indicators of fluid distribution and cellular integrity evaluated by nioelectrical impedance analysis in athletes of different performance levels and non-athletes. The second chapter presents a specific examination of the aryl hydrocarbon receptor among xenobiotic receptors, with a commentary on the preventive and therapeutic abilities of lignans against various diseases associated with the aryl hydrocarbon receptor signaling pathway, including cancers, teratogenesis, inflammatory bowel diseases, osteoarthritis, metabolic syndrome and diabetes, allergic diseases, autoimmune diseases, Alzheimer's disease, Parkinson's disease, leukemias and lymphomas. Additionally, the authors discuss scrub typhus, a bacterial disease caused by Orientia tsutsugamushi (O. tsutsugamushi), and how it is recognized as an important cause of fever in Asia. The objective of the next section is to conduct a literature review to identify key risk factors that contribute to the risk of infection and transmission of disease in residential aged care and community care settings. The indications and complications of surgical management of Choanal atresia will be thoroughly illustrated in the followingchapter, mainly focusing on the role of the transnasal endoscopic approach. Recently, a great deal of emphasis has been placed on the creation of more effective drugs for prevention and management of obesity and obesity-related diseases. The penultimate chapter examines the peptide fraction derived from tissue of Antarctic hydrobiont and how it has beneficial effects on the diet induced obesity in rats through the influence on oxidative status, development of inflammation, and disorders of the serotonergic system, which are considered to be the key pathogenic mechanisms of obesity-associated metabolic disturbances. The focus of the final chapter is to describe the demographic, clinical and microbiological characteristics of S. maltophilia infections in pediatric patients during a two year period (2016 to 2018) in a tertiary-care hospital in southern Brazil.

Smoking is a greater cause of death and disability than any single disease, says the World Health Organisation. According to their figures, it is responsible for approximately five million deaths world-wide every year. Tobacco smoking is a known or probable cause of approximately 25 diseases including cancer, heart attacks and strokes. The WHO says that its impact on world health is still not fully assessed. This book offers leading edge research from around the globe with a focus on smoking cessation and the effects of passive smoking on health.

This book brings together the latest research in the battle against autism. Autism is a complex developmental disability that typically appears during the first three years of life. The result of a neurological disorder that affects the functioning of the brain, autism and its associated behaviours have been estimated to occur in as many as 2 to 6 in 1,000 individuals. Autism is four times more prevalent in boys than girls and knows no racial, ethnic, or social boundaries. Autism is a spectrum disorder. The symptoms and characteristics of autism can present themselves in a wide variety of combinations, from mild to severe. Although autism is defined by a certain set of behaviours, children and adults can exhibit any combination of the behaviours in any degree of severity. People with autism process and respond to information in unique ways. In some cases, aggressive and/or self-injurious behaviour may be present.

This practical manual explains a comprehensive, alternative system of diagnosis and treatment of chronic musculoskeletal pain. Medications and commonly available physical therapies often give only temporary relief. The success of the intramuscular stimulation method described here has led to a new model for chronic pain. The manual, and the techniques described in it, will be invaluable to those seeking a more effective physical modality for the management of chronic musculoskeletal pain.a practical clinical manual showing a clear and coherent approach to the treatment of pain written by Dr Gunn who is an acknowledged expert in this area excellent illustrations guide the practitioner through the techniques described

Svadhyaya (self-reflective) Breath Journal is a companion workbook to Restoring Prana. Restoring Prana is a training manual on transformative breathing for yoga therapists, yoga teachers and bodyworkers and it presents a new way of understanding and applying breath to a wide range of ailments. Each chapter in Restoring Prana ends with specific practices that the reader is asked to track in a breath journal and this workbook provides a pre-formulated journal for this purpose. This workbook follows the chapter chronology of the parent text, with the key concepts highlighted and with space for breath charts, logs and reflection.. Svadhyaya Breath Journal is the perfect companion to Restoring Prana and highlights the importance of practical application of theory discussed in the parent book.

This superbly written text gives students, residents, and practitioners the edge in understanding the mechanisms and clinical management of acid-base disorders. Presents the core information to understand renal and electrolyte physiology, and reviews the treatment rationale for all major acid-base and electrolyte disturbances. The entire text is exhaustively revised, and now includes questions and answers in each chapter.