From an acclaimed author in the field, this is a compelling study of the origins and history of the disease commonly seen as afflicting young unmarried girls. Understanding of the condition turned puberty and virginity into medical conditions, and Helen King stresses the continuity of this disease through history, depsite enormous shifts in medical understanding and technonologies, and drawing parallels with the modern illness of anorexia. Examining its roots in the classical tradition all the way through to its extraordinary survival into the 1920s, this study asks a number of questions about the nature of the disease itself and the relationship between illness, body images and what we should call'normal' behaviour. This is a fascinating and clear account which will prove invaluable not just to students of classical studies, but will be of interest to medical professionals also

This completely revised and updated second edition to integrates the many new technologies and insights now available for the diagnosis of genetic diseases. The authors use such methodologies as PCR optimization dosage analysis, mutation scanning, and quantitative fluorescent PCR for aneuploidy analysis, Neurofibromatosis type 1, and Duchenne muscular dystrophy. These largely generic methodologies may be adapted to most genetic conditions for which a molecular diagnosis is relevant, no matter how frequent or rare their incidence. Molecular Diagnosis of Genetic Diseases, Second Edition offers diagnostic molecular geneticists a unique opportunity to sharpen their scientific skills in the design of assays, their execution, and their interpretation.

Call it a remnant of our Victorian past, but sexual concerns lag behind other aspects of health, both in the training of physicians and therapists and in the way they impart this knowledge to clients. But as sexuality gains recognition as crucial to one's quality of life, evidence-based methods of understanding and discussing sex are imperative-and not only in treating pathology. Sexual Medicine in Clinical Practice provides framework, rationale, and strategies for both approaching sexual problems and addressing patients' questions about sexual health, behavior, and relationships. Analyzing sexuality along three dimensions-attachment, reproduction, and desire-this concise manual offers a biopsychosocial lifespan model readily translatable into clinical work. This "syndyastic" framework integrates attachment and relational theory to reinforce the bond between intimacy and connectedness, and models nonjudgmental approaches to disorders of sexual function, maturity, preference, and behavior. The authors' salutogenic rather than pathogenic focus lets clients become major players in their own healing, and the therapist or doctor serve as expert and guide. Among the topics covered: The communicative function of sexuality. The spectrum of sexual disorders. Principles of diagnostics in sexual medicine. Disease-centered versus client-centered aspects of sexual therapy. Therapeutic approaches for sexual traumatization. New challenges, including preventing child sexual abuse and online sex crime. Plus case studies, interdisciplinary references, and ethical issues. A timely, perspective- and practice-altering volume, Sexual Medicine in Clinical Practice is essential reading for family and primary care physicians, family and sex therapists, health psychologists, and psychiatrists.

Andrology is the fastest growing subspecialty in urology and has recently achieved remarkable advances in the understanding of the erectile mechanism and in reproductive medicine. Male Infertility and Sexual Dysfunction presents all the current avenues of treatment with emphasis on multidisciplinary considerations. Chapters are written by select international authorities presenting indepth coverage of their areas of expertise. Each topic will cover the background, anatomy, physiology, diagnosis, classification, and treatment (medical and/or surgical). Part I focuses on the study of male infertility and includes discussions of the basic sciences, office evaluation, laboratory and imaging techniques, and the use of testicular biopsy. This is followed by specialized chapters dealing with immunologic infertility, genital inflammation, reactive oxygen species, medical management, sperm processing and preventive adolescent andrology. Part II reflects a more diverse format in the coverage of sexual dysfunction and includes discussions of androgen insufficiency, nocturnal penile tumescence studies, neurotransmission, penile neurology, premature ejaculation, psychogenic impotence and the latest medical, noninvasive and surgical treatments.

Pharmacogenetics is becoming increasingly relevant in the diagnosis, treatment, and recovery of cancer patients. A major problem facing oncologists is the outstanding varied efficacy of treatment. Promising advances in pharmacogenetics have allowed the development of effective agents which will enable personalized cancer chemotherapy to become routine for the clinical practice.

Written by experts in the field and combining information that is unable to be found in a single source volume, Pharmacogenetics of Breast Cancer

• combines a complete overview of pharmacogenetics and how it relates to breast oncology for diagnosis, treatment, and the recovery of patients using an individualized therapy model
• is the first single source reference demonstrating the application of pharmacogenetics in the care of breast cancer patients
• enables physicians a coherent interpretation of the emerging science of pharmacogenetics, aiding them to incorporate individual therapies in their own practice
• gives practical guidance on various forms of specimen collection, tissue selection, and handling procedures

Recent advances in immunology and biology have opened new horizons in cancer therapy, included in the expanding array of cancer treatment options, which are immunotherapies, or cancer vaccines, for both solid and blood borne cancers. Cancer Vaccines: Challenges and Opportunities in Translation is the first text in the field to bring immunotherapy treatments from the laboratory trial to the bedside for the practicing oncologist. Cancer Vaccines: Challenges and Opportunities in Translation: Critically analyzes the most promising classes of investigational immunotherapies, integrating their scientific rationale and clinical potential Discusses "theranostics" as pertaining to immunotherapy, i.e., using molecular diagnostics to identify patients that would most likely benefit from a therapy Presents the new paradigm of biomarker guided R&D and clinical development in immunotherapy of cancer Reviews bottlenecks in translational process of immunotherapies and offers strategies to resolve them

Just a few decades ago, children born with significant congenital anomalies or genetic and metabolic diseases perished at an early age and very few survived into their teens and even less into adulthood. Congenital heart disease, major errors in metabolism, cancer, cystic fibrosis and many other major diseases were fatal. Because of that many physicians in adult primary care did not have the opportunity to see patients with these problems and thus unable to learn how to care for them. In this book, we have recruited highly qualified and experienced physicians to compile what is to the best of our knowledge, the first book dealing entirely with the issue of children's diseases in adults. Our goal is to provide a resource for all health care providers in order to help with caring for such adult patients. We believe that it will be valuable to all health care providers who provide care to adults with children's diseases. To our knowledge, there is no such resource available for practitioners which will make this book desirable.

Fainting, the sudden and often unpredictable loss of consciousness, can be a frightening experience. While often benign, fainting can sometimes be the sign of serious illness. Recurrent fainting can significantly disrupt a person's life, and make them prone to injury and, on occasion, death.

"The Fainting Phenomenon, "Second Edition is a valuable information resource for anyone whose life is affected by fainting.

Written for the layperson, this book will help you:
Understand the different reasons why people faint and their significance
Seek proper medical attention and treatment
Deal with related conditions such as Postural Tachycardia Syndrome and Orthostatic Hypertension

This is an indispensable and reassuring guide for parents, families and care givers.

Multiple myeloma is the second most prevalent hematological malignancy, with over 55,000 new cases diagnosed each year. This exciting new text, edited by lauded authorities on the topic, stands as the only available reference to assemble, review, and synthesizes the latest studies on translational therapies and clearly explains the impact of molecular pathogenesis, biology, and prognostic factors on the diagnosis, prognosis, and individualization of treatment and the development of novel therapeutic options for patients with myeloma. Moving from the bench to the bedside to the forefront of therapeutic development, this source: helps clinicians and researchers effectively deploy therapeutic strategies into clinical practice reflects trends in the use of agents which target both the tumor cell and its bone marrow microenvironment to overcome resistance to conventional therapies considers the critical role of the bone marrow microenvironment in the regulation of growth, survival, and homing of multiple myeloma discusses novel therapies in phase I and phase II trials, focusing specifically on therapeutic options for patients with newly diagnosed or relapsed/refractory multiple myeloma addresses novel therapies for other plasma cell disorders, and provides the framework for the design of next generation agents and combination therapies covers the entire scope of translational work in multiple myeloma, from advances in molecular pathogenesis, to prognostic factors, immunotherapy, and new options for newly diagnosed and relapsed multiple myeloma patients

Emphasizing new and emerging therapies in each chapter, this reference provides essential information for clinicians to provide accurate diagnoses and select the most appropriate treatment regimens for patients with primary and metastatic brain tumors and neurological complications of cancer. Edited by a leading cast of authorities on the topic-including the Chief and Associate Editors of the Journal of Neuro-oncology-this easily-accessible guide reviews the epidemiology, identification, and management of brain tumors while exploring the latest advances in this increasingly diverse field.

In this issue of Critical Care Clinics, guest editors Drs. Robert M. Kliegman and Brett J. Bordini bring their considerable expertise to the topic of Undiagnosed and Rare Diseases in Critical Care. Top experts in the field cover key topics such as critical genetic arrhythmia disorders, uncommon causes of rhabdomyolysis, status epilepsy syndromes, autoimmune encephalitis, rapid-onset paralysis and weakness, and more. Contains 17 relevant, practice-oriented topics including understanding cognitive diagnostic errors in the ICU; rapid WES/WGS in the ICU; diagnostic time-outs to improve diagnosis; when "sepsis" is not sepsis: MAS, HLH, malignancies and other sepsis mimics; all that wheezes is not asthma or bronchiolitis; and more. Provides in-depth clinical reviews on undiagnosed and rare diseases in critical care, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Scientists have reached a critical point in the development of new therapies for prostate cancer. The information gleaned from the Human Genome Project, alongside the emergence of new technologies for the use of genetic data has expanded the physician's understanding of disease progression and widened his armamentarium for prostate cancer prevention and control. This expertly-written reference thoroughly analyzes the scientific principles and methodologies behind the most recent translational therapies and provides the necessary context, data, and studies for practitioners to select appropriate candidates for treatment and effectively apply new therapies in clinical practice.

The current interest in prion diseases has been fueled by the panic that originated from the appearance of a new variant of Creutzfeldt-Jakob disease and the evidence linking it to human exposure to the bovine spongiform encephalopathy (BSE) agent. Peer-reviewed to assure accuracy, this book describes the science, concepts, hypothesis, and mechanisms of prion disease transmission. It covers human and animal prion diseases, their incidence, prevalence, origin, and clinical and neuropathologic characteristics. The author provides scientific facts and a clear explanation of the relevance and implications of the findings for science in general.

After half a century of doubt and debate, dyslipidemia has at last been accepted by cardiologists and the medical community at large as a major, treatable cause of atherosclerotic cardiovascular disease. Written by a general practitioner, an epidemiologist, and a lipidologist, this updated second edition provides a broad, cutting-edge perspective of dyslipidemia, presenting the very latest information on lipid disorders from etiology to management. Clear, concise and highly illustrated, this user-friendly work: details normal lipid metabolism; describes the genetic and acquired causes of excessively high cholesterol disorders; reviews the evidence that dyslipidemia is a risk factor for vascular disease; and includes chapters summarising current US, British and European guidelines, the importance of diet and the role of lipid-lowering drugs. A highly practical text providing sound advice on screening, risk assessment and the management of dyslipidaemia, this second edition of Dyslipidemia in Clinical Practice is essential reading for a wide range of specialists who are increasingly dealing with patients with excessively high cholesterol disorders.

What is it about the challenges and stresses of midlife that disrupts equilibrium and promotes a sense of despair, even of crisis? Why does this stage of the life cycle give rise to new mental and physical symptoms that, for some, lead to chronic unhappiness to the point of dysfunction? Of course, there are common midlife events that account for the special narcissistic vulnerabilities of this period of life, and Eda Goldstein ably reviews these events and the theoretical perspectives commonly brought to bear on them. In When the Bubble Bursts, however, Goldstein's special concern is those individuals who come to midlife with heightened narcissistic vulnerabilities that make the navigation of this stage of life more difficult still. In understanding the latter such patients and devising a treatment approach appropriate to their self issues, Goldstein adopts a broadly self-psychological frame of reference. It is a matter, she finds again and again, of understanding how current stressors frustrate healthy self needs and trigger narcissistic vulnerabilities. purview, embraces modalities that are, to varying degrees, supportive, psychodynamic, and psychoanalytic, reworks and strengthens self structures in helping patients find new ways of affirming their sense of self. Her substantive case studies, which accompany the reader through all the chapters in her study, draw on personal and supervisory experiences to illustrate crucial foci of the treatment process with a range of midlife patients in psychotherapy. It is a striking that, amid a voluminous literature on psychodynamic psychotherapy, so little attention has been paid to the narcissistic vulnerabilities of midlife and the manner in which they enter into the psychotherapy of midlife patients. Eda Goldstein remedies this glaring lacuna in the literature with a study that comprises an admirable blend of theoretical astuteness, clinical wisdom, and personal honesty. balanced discussion of theoretical perspectives on adult development and her concluding consideration of the countertransference issues elicited by midlife patient in their midlife therapists, is an edifying and ingratiating contribution to the literatures of psychodynamic psychotherapy, self psychology, and adult development.

This book, besides reviewing basic and clinical aspects of Behcet's disease, covers the latest findings, including genetic studies and treatment with biologics for the disease. Although the cause of Behcet's disease is still unknown, it is well known that genetic factors, such as HLA-B51, are involved in its development. Recently, novel susceptibility loci including IL10, IL23R-IL12RB2, and endoplasmic reticulum aminopeptidase 1 have been identified, providing new insights into the pathogenesis of the disease. In addition to basic research, the beneficial efficacy of anti-TNF-alpha monoclonal antibodies has also been suggested for not only uveitis associated with the disease but also other subtypes of the disease such as entero-, vasculo-, and neuro- Behcet's disease. Behcet's Disease: From Genetics to Therapies provides essential information both for basic researchers working in the fields of immunology, inflammation, and genetics, and for clinical physicians who are interested in Behcet's disease, such as ophthalmologists, rheumatologists, dermatologists, gastroenterologists, neurologists, and vascular surgeons.

This reference analyzes the cellular and molecular biology and mechanisms of the blood-brain barrier (BBB) and presents the most recent studies on the role of the BBB in the development and initiation of a wide range of physiological and pathological conditions affecting the central nervous system.

With a greater emphasis on the basic principles, practical recommendations, and economics of phototherapy, the Third Edition remains the standard source on the UV treatment of skin disease-presenting an expanded number of case studies, clinical solutions, and treatment protocols for a clear understanding of the present and future state of phototherapy, photochemotherapy, and phototesting in the dermatologic arena.

This reference discusses state-of-the-art methods for the management of children with conditions affecting the nervous system-providing over 80 chapters that outline direct, logical approaches to numerous pediatric neurologic disorders using clear tables, algorithms, and figures for quick reference to key material.

This publication provides a state-of-the-art overview of key issues related to antimicrobial resistance, including a focus on key pathogens causing common healthcare-associated and community-acquired infections. The epidemiology and therapeutic considerations of these antimicrobial resistant organisms are discussed, as well as the clinical and health economic impact of infections caused by them. This progressive reference also provides a dedicated section covering the clinical programmatic strategies used to minimize the growing antimicrobial resistance problem, including practical information related to interventional concepts and their implementation. In addition to antimicrobial resistance in the context of traditionally discussed problematic bacterial pathogens, emerging data related to clinically important fungal pathogens and Clostridium difficile are also covered.

The book shows how mathematical and computational models can be used to study cancer biology. It introduces the concept of mathematical modeling and then applies it to a variety of topics in cancer biology. These include aspects of cancer initiation and progression, such as the somatic evolution of cells, genetic instability, and angiogenesis. The book also discusses the use of mathematical models for the analysis of therapeutic approaches such as chemotherapy, immunotherapy, and the use of oncolytic viruses.

Parenteral nutrition is the standard of care for patients who are unable to maintain nutritional status via the gastrointestinal tract. New techniques in this therapy are giving patients with intestinal failure the time they need to achieve maximal intestinal rehabilitation and return to a more normal and productive life. Edited and written by an international group of experts in the field, Intestinal Failure and Rehabilitation: A Clinical Guide presents the most current information regarding the prevention, diagnosis, care, and management of patients with intestinal failure. Organized in a logical manner, the book opens with a review of the basic principles and concepts, and progresses into discussions on diagnostic evaluation using a variety of techniques, and treatment plan formulation. The next section addresses dietary modifications, medical management, the use of trophic substances, enteral and parenteral nutrition, surgery, and transplantation. Following a discussion of special considerations, such as pediatrics and enterostomaltherapy, the text concludes with outcomes and future directions for research. This volume is devoted solely to intestinal failure and all of the information is supported by evidence-based medicine. It greatly enhances understanding of this area and aids in the care and rehabilitation of individuals with intestinal insufficiency.

The information in Healthy Solutions can help readers maintain and enhance their own health. Readers will come to understand how natural medicine views health, disease, and healing. Also, how to interpret the body's reaction to illness, and become familiar with self-care remedies for more than 50 health conditions. Explains how to use homopathic tissue salts for treating symptoms, and how to master the therapeutic uses of herbs, spices, and foods.