A handy manual for cornea specialists, this book provides detailed practical information about a complex, sight-threatening disease that can be challenging to diagnose and manage. This text features chapters dedicated to outlining all facets of diagnosis and management while covering both medical and surgical treatment options. Peripheral Ulcerative Keratitis, supplemented with useful references and appendices to provide simple step by step algorithms, is written by internationally renowned authors who are experts in the field.Including practical tips and guidelines for diagnosis and therapy of these disorders, Peripheral Ulcerative Keratitis is designed to serve as a guide for comprehensive ophthalmologists and should find itself on the bookshelves of ophthalmology clinics, corneal practices and training programs across the country.

In the United States alone, roughly 300,000 children suffer from some form of arthritis or rheumatic disease, and millions more are at risk of developing one of these diseases. In this marvelously down-to-earth guide, Thomas Lehman--the head of one of the leading pediatric rheumatology programs in the world--offers a gold mine of expert advice invaluable for pediatricians who want to become more proficient in understanding, diagnosing, and treating rheumatic disease in children. Dr. Lehman helps pediatricians interpret their patients' complaints and determine whether and what type of medical attention is needed, explaining what symptoms to look for, what questions to ask, what tests to run, and what to expect when treatment begins. Using illustrative anecdotes, this book sheds light on a wide range of rheumatic disorders--including juvenile arthritis, Lyme disease, lupus, Kawasaki disease, fibromyalgia, and chronic fatigue syndrome--and it addresses such crucial topics as drug safety, genetic considerations, the potential risks to children posed by medications, the difficulty of family life when a child has a chronic disease, and much more.
A Clinician's Guide to Rheumatic Diseases in Children captures the expertise of a dedicated physician with over thirty years of hands-on experience helping children lead normal, happy lives. It will help pediatricians make sure that patients achieve the best possible outcome.

A leading mind-body researcher provides an invaluable resource of solid scientific evidence for consciousness-based healing--along with practices anyone can use. Spontaneous remission, the placebo effect, and energy healing--these phenomena have baffled the medical community for decades. What do all these marvels tell us? "Our current models of medicine fall short of understanding the depths of our human healing potential," says Dr. Shamini Jain. "We are on the cusp of finally becoming awake to our human healing potential. A growing number of scientists are exploring a new path--a true expansion of science joined with understandings from ancient concepts of spirituality." With Healing Ourselves, Dr. Jain presents a new vision of health and healing. Here she rejects the "either-or" thinking that has placed conventional medicine at odds with so-called alternative methods--offering an integrated path based on sound scientific evidence and personal empowerment. Join her to explore: - Biofield science--peer-reviewed research on the inseparable relationship between consciousness and healing - The placebo and beyond--what placebo research tells us about the power of consciousness to heal ourselves, whether we choose drugs, surgery, or holistic medicine - Evidence--what strong, published research actually says about the healing power of holistic practices such as yoga, tai chi, meditation, and energy healing - The Healing Keys--in-depth instruction with evidence-based recommendations and ancient spiritual practices that you can integrate into your life for healing yourself Today more than ever, we realize that we must change the way we think about health care--and our ability to heal ourselves. "The good news is there is a way forward," teaches Dr. Jain. "The flame that lights the path burns brighter than the darkness of ignorance and suffering we have found ourselves in." With Healing Ourselves, this inspiring teacher shares a holistic model of health that we have known in our hearts, all along, to be true.

In this up-to-date survey and critical assessment of transgenic and knockout models in neuropsychiatry and behavior, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond. The authors focus on transgenic and knockout models of neurocognitive dysfunction and neuropsychiatric dysfunction. The discussion of neurobiological problems covers mental retardation, polyglutamate, and speech disorders, as well as disorders that involve cognitive, social, speech, and language dysfunction. The neuropsychiatric dysfunctions examined include psychosis and schizophrenia, anxiety, depression, and bipolar disorder.

Medicinal Chemistry Approaches to Malaria and Other Tropical Disease, Volume 53 in the Annual Reports in Medicinal Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Epilepsy has a fascinating history. To the medical historian Oswei Temkin it was 'the paradigm of the suffering of both body and soul in disease'. It is justifiably considered a window on brain function. And yet its story is more than simply a medical narrative, but one influenced also by scientific, societal and personal themes. Written for a medical and non-medical readership, this book describes the major developments in epilepsy between 1860-2020, a turbulent era in which science dominated as an explanatory model, medical theories and practices steered an erratic course, and societal attitudes and approaches to epilepsy fluctuated dramatically. In the middle of this maelstrom was the person with epilepsy at the mercy of social attitudes and legislation, and at times harmed as well as helped by medicine and science. So entangled is the history that intriguingly, as an entity, epilepsy may now be thought not even to exist.

The Motoneurone and its Muscle Fibres presents a state-of-the-art summary of knowledge concerning the motoneurones, vital for innervating and commanding skeletal muscles. No muscle action would be possible without motoneurones. These cells are therefore absolutely essential for the execution of normal behaviour and for life support. It is their degeneration that leads to various kinds of motoneurone disease (e.g. ALS) that are often ultimately lethal. However, the study of motoneurones is also important for general insights as to how neurones work, because the motoneurone is probably the best understood kind of nerve cell so far in neuroscience. Motoneurones of the spinal cord were the first type of central nerve cell to be subjected to detailed physiological measurements, and much is known about how their activity is regulated by synapses from other central neurones. For most of the individual neurones within the central nervous system, the precise functional tasks are difficult to define. However, for motoneurones much is now known about their short- and long-term interactions with their main targets, the skeletal muscle fibres. Functions of neurones must be analyzed in relation to the response properties of their target cells. Therefore, this book deals with both, summarizing classical as well as recent knowledge concerning the motoneurone and its muscle fibres. This is the first time that so many aspects of this broad subject matter are treated in one comprehensive monograph.

This book is an amalgamation of knowledge, experience, and expertise in various aspects of nanotechnology, by experts who are proficient in designing of novel nanoformulations that are used in the treatment of various challenging and prevalent diseases. It is an exhaustive compilation of the multi-faceted arena of nanoformulations and the healthcare system that caters to the needs of academicians, scholars, researchers etc. The most important aspect of the book covers various types of nanoformulations and their applications in treatment of communicable and non-communicable diseases. Each chapter focuses on a particular nanoformulation as well as a disease including the pathophysiology of the disease, the current treatment modalities of diseases, the role of nanoformulation in treatment and other future aspects and directions for further work. Coverage includes neuropathic pain, colon targeting, nose-to-brain drug delivery, skin cancer, arthritis and tuberculosis.

Manifesting Happy is a journey of self-care for educators. The book is recognition of the essential capacity that educators fulfill each and every day. By combining two foundational theories, the dimensions of wellness and applied behavior analysis, readers will create a comprehensive self-care plan by which they can manifest a stronger sense of self and well-being. The book provides an overview of the eight dimensions of wellness and introduces opportunities to gain a better sense of holistic balance. Readers will be exposed to the science of behavior analysis and the benefits of grounding wellness to the scientific principle of the functions of behavior. Through an easy to follow four step planning process of Discover, Define, Design, and Do educators can create a self-care plan that will help them to manifest their happy in order to best support students in the classroom. The book also includes self-care strategies to practice and even ideas to implement with students.

The disorders induced by iodine deficiency affect at least one billion people. Because ofits effects on brain development, iodinedeficiency is the single most preventable cause of mental retardation in the world. Therefore, the United Nations and the Heads of State of almost all the world's countries represented at the Summit for Children in 1990 adopted resolutions to eradicate the disorders induced by iodine deficiency (IDD) by the year 2000. For geological and socio-economic reasons, most of the populations affected by iodine deficiency disorders live in isolated and usually mountainous areas, in pre industrialized parts ofthe world. The problem of iodine deficiency in Europe has been greatly underestimated in the last decades. After the remarkable studies on the effects of iodine deficiency and their prevention and correction in Switzerland, IDD was generally considered no longer a significant public health problem in Europe. However, surveys carried out in the early 1980's under the auspices of the European Thyroid Association, clearly demonstrated the persistence of moderately or even severely affected areas. These surveys also highlighted the lack ofinformation about large parts ofEurope, especially its eastern part. It is only quite recently, following major changes in international relations and thanks to the support of UNICEF, WHO, the International Council for the Control of Iodine Deficiency Disorders and the European Thyroid Association, that more extensive surveys have been conducted in several parts of Europe hitherto almost unexplored. These surveys showed that most European countries were iodine deficient."

Respiratory function is a major determinant of the overall quality of health and well-being of an individual. This book runs the gamut of chapters devoted to chronic cough-related conditions in children and adults, health care quality and safety, environmental pollution health effects, efficiency of therapeutic approaches and a mutual dependence of respiratory and non-respiratory illnesses. An integrated approach to the investigation and treatment of sleep disordered breathing as well as the use of new and more efficient diagnostic strategies for pleural tuberculosis are presented. Chapters focus on translating science into practice, with an eye on presymptomatic identification of serious ailments for which there could be more effective therapy, leading to improved general health outcomes. This book includes chapters about disorders which will be of interest to clinicians, family practitioners and medical researchers.

This up-to-date reference book discusses the synthesis, production, and application of various microbial enzymes and metabolites for health. Microorganisms like bacteria (lactic acid bacteria, Bacillus species), yeasts, and filamentous fungi have been globally exploited for their biotechnological applications. This book discusses ways to use them commercially. Chapters include the production of fibrinolytic enzymes, microbial lipases, bacteriocin production by lactic acid bacteria, and bioactives produced. It also covers microbial synthesis of alkaloids, terpenoids, and steroids. The book is useful for researchers, academicians, and industry experts in microbiology and biotechnology.

This up-to-date reference book compiles the recent developments, innovations, and perspectives on second and third-generation bioplastics. It discusses the main commercialized bioplastics, such as polylactic acid (PLA) and polyhydroxyalkanoates (PHAs). Chapters include the use of alternative raw materials and innovations in bioplastic production processes to reduce costs and decrease environmental impacts. It covers bioplastic production from lignocellulosic biomass, sugars, or oils produced by microbes and municipal waste material. It also includes techno-economic aspects. The book is meant for researchers and industry experts in biotechnology, environmental sciences, and applied microbiology.

Challenging the concept that since the discovery of the plague bacillus in 1894 the study of the disease was dominated by bacteriology, Ethnographic Plague argues for the role of ethnography as a vital contributor to the configuration of plague at the turn of the nineteenth century. With a focus on research on the Chinese-Russian frontier, where a series of pneumonic plague epidemics shook the Chinese, Russian and Japanese Empires, this book examines how native Mongols and Buryats came to be understood as holding a traditional knowledge of the disease. Exploring the forging and consequences of this alluring theory, this book seeks to understand medical fascination with culture, so as to underline the limitations of the employment of the latter as an explanatory category in the context of infectious disease epidemics, such as the recent SARS and Ebola outbreaks.

Genomic and Precision Medicine: Foundations, Translation, and Implementation highlights the various points along the continuum from health to disease where genomic information is impacting clinical decision-making and leading to more personalization of health care. The book pinpoints the challenges, barriers, and solutions that have been, or are being, brought forward to enable translation of genome based technologies into health care. A variety of infrastructure (data systems and EMRs), policy (regulatory, reimbursement, privacy), and research (comparative effectiveness research, learning health system approaches) strategies are also discussed. Readers will find this volume to be an invaluable resource for the translational genomics and implementation science that is required to fully realize personalized health care.