Biologics and Biosimilars: Drug Discovery and Clinical Applications is a systematic integration and evaluation of all aspects of biologics and biosimilars, encompassing research and development, clinical use, global regulation, and more. Biosimilars are biological therapeutic agents designed to imitate a reference biologic with high similarities in structure, efficacy, and safety, but also with potential clinical effective and cost-efficient options for the manufacturers, payers, clinicians, and patients. Most of the top-selling prescription drugs in the current market are biologics, which have revolutionized the treatment strategies and modalities for life-threatening and/or rare diseases. This book outlines the key processes and challenges in drug development, regulations, and clinical applications of biologics, biosimilars, and even interchangeable biosimilars. Global experts in the field discuss essential categories and prototype drugs of biologics and biosimilars in clinical practice such as allergenics, blood and blood components, cell treatment, gene therapy, recombinant therapeutic proteins or peptides, tissues, and vaccines. Additional features: Integrates the latest bench and bedside evidence of drug development and regulations of biologics and biosimilars Contains key study questions for each chapter to guide the readers, as well as drug charts for all therapeutic applications of biologics and biosimilars Presents detailed schematic illustrations to explain the drug development, clinical trials, regulations, and clinical applications of biologics and biosimilars This book is an invaluable tool for health care professional students, providers, and pharmaceutical and health care industries, as well as the public, providing readers with educational updates about the drug development and clinical affairs of biological medications and their similar drugs.

This book is designed to provide a comprehensive and state-of-the-art resource for clinicians who care for patients with sepsis and research scientist alike, . Patients with severe sepsis requiring ICU admission have very high rates of ICU and overall hospital mortality, with estimates ranging from 18 to 50%. Risk factors for death from sepsis include underlying illness, increased age, and multi-system organ failure. This is compounded by the significant variation in the management of early severe sepsis. Care of these patients and clinical conditions can be quite complex, and materials are collected from the most current, evidence-based resources. Book sections have been structured to review the overall definitions and epidemiology of sepsis as well as current insights into the pathophysiology of sepsis. This review summarizes the evidence for the international consensus guidelines for the identification and management of sepsis. The latter part of this book reviews emerging concepts and approaches in the diagnosis and management of sepsis that may significantly reduce mortality in the future. Sepsis: Pathophysiology, Definitions and the Challenge of Bedside Management represents a collaboration between authors drawn from a variety of disciplines and contributions from basic scientists and highly recognized clinical opinion leaders with expertise in clinical trials.

During the last 1500 years, Rome was the inspiration of artists, the coronation stage of German emperors, the distant desire of pilgrims, and the seat of the Roman popes. Yet Rome also lies within the northern range of P. falciparum malaria, the deadliest strain of the disease, against which northern Europeans had no intrinsic or acquired defenses. As a result, Rome lured a countless number of unacclimated transalpine Europeans to their deaths in the period from 500 to 1850 AD. This book examines how Rome's allure to European visitors and its resident malaria species impacted the historical development of Europe. It covers the environmental and biological factors at play and focuses on two of the periods when malaria potentially had the greatest impact on the continent: the heyday of the medieval German Empire and its conflicts with the papacy (c. 800-1300) and the Protestant Reformation (c.1500). Through explorations into the history of religion, empire, disease, and culture, this book tells the story of how the veritable capital of the world became the graveyard of nations.

In this work, leading physicians; hepatologists; pharmacologists; pathologists; and transplant surgeons discuss the most recent advances in the field of liver disease and its treatment. Attention is focused on epidemiology; the diagnosis of disease (clinical chemistry, histopathology, medical imaging analysis); prognosis; prediction; and clinical management. Pathogenesis of diseases such as liver cirrhosis following viral disease or alcohol abuse are discussed at length, and special attention is dedicated to high risk patients (children, fulminant hepatitis). The other major topics include terminal liver failure, for which transplantation is now routine. The latter is discussed in depth, starting from the organ donor management; organ evaluation and preservation; new surgical techniques; post-transplant patient follow-up including side effects of immunosuppression; and reports of the latest drugs used to prevent rejection.

The book provides a comprehensive overview to understanding the integrated impact of the concepts of cellular and molecular aspects, models, environmental factors, and lifestyle involved in premature aging. Additionally, it examines how functional food, dietary nutraceuticals or pharmacological compounds can reverse inflammation and premature aging based on personalized medicine. This book is a valuable resource for health professionals, scientists and researchers, nutritionists, health practitioners, students and for all those who wish to broaden their knowledge in the allied field.
Includes models of aging, including worm, mouse and humanExplores the relationship of inflammation with diseases, including ocular health, Alzheimer's and Parkinson's disease, and muscle healthEncompasses a variety of lifestyle impacts, including diet, exercise and nutritionIncludes suggested nutritional interventions

The international symposium "Syringomyelia 2000" in Kobe, Japan, brought together experts in neurosurgery, neurology, and neuropathology. The decade leading up to this event saw remarkable developments in surgery and imaging technology. The symposium was thus an opportunity for researchers and clinicians to enhance and broaden the scope of their knowledge and to become more aware of work being done in complementary fields. With its collection of papers presented at the Kobe conference, this volume contains a thorough and comprehensive description of syringomyelia - its classification, pathology, and pathophysiology; experimental studies; and its association with abnormalities of the craniocervical junction, Chari II malformation, tethered cord, and other disorders. This compilation provides valuable state-of-the-art information for professionals in the fields of neurosurgery, neurology, and neuropathology and for all others concerned with syringomelia.

Medicinal Chemistry Approaches to Malaria and Other Tropical Disease, Volume 53 in the Annual Reports in Medicinal Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Individuals with serious and persistent mental illnesses, including schizophrenia and affective disorders, often experience cognitive deficits that make it challenging to perform everyday tasks. For example, they may have difficulty paying attention, remembering and learning, thinking quickly, and solving problems, and this may interfere with functioning at work, school, and in social and living situations. Cognitive remediation is an evidence-based behavioral treatment for people who are experiencing cognitive impairments that interfere with role functioning. Cognitive Remediation for Psychological Disorders contains all the information therapists need to set up a cognitive remediation program that helps clients strengthen the cognitive skills necessary for everyday functioning. The program described is called Neuropsychological and Educational Approach to Remediation (NEAR), an evidence-based approach that utilizes carefully crafted instructional techniques which promote learning. The goals of NEAR are to provide a positive learning experience and to promote independent learning and optimal cognitive functioning in daily life. The second edition of this popular Therapist Guide provides step-by-step instructions on how to implement NEAR techniques with patients. Guidelines for setting up and running a successful cognitive remediation program are laid out in an easy-to-follow format. Therapists will learn how to choose appropriate cognitive exercises, recruit and work with clients, perform intakes, and create treatment plans. This Guide comes complete with all the tools necessary for facilitating treatment, including program evaluation forms and client handouts.

Master the nurse's role in therapeutic nutrition and in teaching dietary health! Nutritional Foundations and Clinical Applications: A Nursing Approach, 8th Edition describes nutritional healing and wellness from the nurse's perspective. It covers dietary guidelines with a humanistic, personal touch, using first-hand accounts to show how nutrition principles apply to patients in real-world practice. This edition is updated with the most current guidelines and the latest research on nutrition. Written by noted educators Michele Grodner, Sylvia Escott-Stump, and Suzie Dorner, this leading nutrition text promotes healthy diets and shows how nutrition may be used in treating and controlling diseases and disorders. Applying Content Knowledge and Critical Thinking: Clinical Applications case studies help you apply nutrition principles to real-world practice situations. Personal Perspective box in each chapter offers a firsthand account of the ways in which nutrition affects patients' lives, demonstrating the personal touch for which this book is known. Teaching Tool boxes include strategies for providing nutrition counseling to patients. The Nursing Approach boxes analyze a realistic nutritional case study according to the nursing process. Social Issue boxes show how ethical, social, and community concerns can influence health and wellness. Health Debate boxes address the nurse's response to differing opinions or controversies about food, nutrition, and health concerns. Cultural Considerations boxes show how to understand and respect the food and health customs of specific ethnic groups. Key terms and a glossary make it easy to learn key vocabulary and concepts. NEW! Nursing Approach sections include Next Generation NCLEX (R) terminology as well as single-episode cases and questions, with answers on the Evolve website.

Biotherapy is defined as the use of living organisms in the treatment and diagnosis of human and animal diseases. This volume is an evocative exploration of the history, scientific basis and practical use of the major biotherapy modalities. The authors provide researchers and practitioners interested in this field, with cutting-edge material on the latest key advances in the following fields of biotherapy: Maggot Therapy, Hirudotherapy, Bee Venom Therapy, Apitherapy, Ichthyotherapy, Helminth Therapy, Phage Therapy, Animal Assisted Therapy, Canine Olfactory Detection. In addition, the authors provide with their chapters an extensive bibliography that represents a state-of-the-art survey of the literature. Comprehensive and current, this fresh volume of reviews is an essential resource for professionals who need to stay ahead of the game in the exciting field of biotherapy.

This book is open access under a CC BY license.
The grand narrative of twentieth-century medicine is the conquering of acute infectious diseases and the rise in chronic, degenerative diseases. The history of fungal infections does not fit this picture; indeed, it runs against it - this book charts the path of fungal infections from the mid nineteenth century to the dawn of the twenty-first century, both in Britain and the United States. It examines how fungal infections became more prevalent and serious over the century, a rise that was linked to the increased incidence of chronic diseases and to social, technological and medical 'progress'. In 1900, conditions such as ringworm, athlete's foot and thrush were minor, external and mostly chronic conditions - irritating, but mostly self-limiting. In the subsequent decades, these infections remained very common, but were better controlled by antifungal drugs. However, by the year 2000 doctors were faced by a growing number of serious and life-threatening fungal infections, such as invasive aspergillosis and systemic candidiasis. These infections principally affect patients who have benefited from medical advances, such as antibiotic treatment and transplantation, and those with immuno-compromised conditions.

Genomic and Precision Medicine: Foundations, Translation, and Implementation highlights the various points along the continuum from health to disease where genomic information is impacting clinical decision-making and leading to more personalization of health care. The book pinpoints the challenges, barriers, and solutions that have been, or are being, brought forward to enable translation of genome based technologies into health care. A variety of infrastructure (data systems and EMRs), policy (regulatory, reimbursement, privacy), and research (comparative effectiveness research, learning health system approaches) strategies are also discussed. Readers will find this volume to be an invaluable resource for the translational genomics and implementation science that is required to fully realize personalized health care.

Part of the "What Do I Do Now?: Palliative Care" series, Pain uses thought-provoking, real-world cases to illustrate concepts, approaches to therapy, and potential barriers to optimal care presented by a diverse panel of interdisciplinary authors. Pain is a frequent and distressing symptom encountered by those with serious or life-limiting illness and may present in a multitude of fashions and from a wide array of etiologies. This book intertwines pharmacologic, nonpharmacologic, and ethical principles of pain control within case-based discussions, allowing readers to expect: * Unique perspectives of pain control, from numerous essential members of the healthcare team; * An engaging collection of cases that illustrate the most current approaches to the most commonly encountered pain syndromes in palliative care; * Chapters that begin with cases and that utilize a conversational tone throughout, like a "curb-side" consult with a seasoned colleague. Consisting of 46 chapters that cover everything from antidepressants to cannabis, cultural competency to bone pain, this volume is also a self-assessment tool that tests the reader's ability to answer the question, "What do I do now?"

This book presents an up-to-date survey of the current scientific understanding of obesity and the metabolic syndrome, as well as an overview of the most significant changes to the field over the past 30 years. The book defines obesity and realistically assesses its prevalence. It further examines and evaluates the success of traditional cognitive behavioral treatment. This volume is a thorough reference for obesity and the metabolic syndrome.

Manifesting Happy is a journey of self-care for educators. The book is recognition of the essential capacity that educators fulfill each and every day. By combining two foundational theories, the dimensions of wellness and applied behavior analysis, readers will create a comprehensive self-care plan by which they can manifest a stronger sense of self and well-being. The book provides an overview of the eight dimensions of wellness and introduces opportunities to gain a better sense of holistic balance. Readers will be exposed to the science of behavior analysis and the benefits of grounding wellness to the scientific principle of the functions of behavior. Through an easy to follow four step planning process of Discover, Define, Design, and Do educators can create a self-care plan that will help them to manifest their happy in order to best support students in the classroom. The book also includes self-care strategies to practice and even ideas to implement with students.

Manifesting Happy is a journey of self-care for educators. The book is recognition of the essential capacity that educators fulfill each and every day. By combining two foundational theories, the dimensions of wellness and applied behavior analysis, readers will create a comprehensive self-care plan by which they can manifest a stronger sense of self and well-being. The book provides an overview of the eight dimensions of wellness and introduces opportunities to gain a better sense of holistic balance. Readers will be exposed to the science of behavior analysis and the benefits of grounding wellness to the scientific principle of the functions of behavior. Through an easy to follow four step planning process of Discover, Define, Design, and Do educators can create a self-care plan that will help them to manifest their happy in order to best support students in the classroom. The book also includes self-care strategies to practice and even ideas to implement with students.

The field ofneurodegenerative diseases is undergoing an unprecedented revolution. The past decade has seen the identification of new mutation mecha- nisms, such as triplet repeat expansions, and new genes causing familial forms of common neurodegenerative diseases, such as Parkinson's and Alzheimer's diseases. Cellular and animal models based on this genetic information are now available and, importantly, common mechanisms are rapidly emerging among diseases that were once considered unrelated. The field is poised for the development of new therapies based on high throughput screenings and a bet- ter understanding of the molecular and cellular mechanisms leading to neurodegeneration. Molecular Mechanisms of Neurodegenerative Diseases reviews recent progress in this exploding field. By nature, such a book cannot be all inclu- sive. It focuses on Alzheimer's, Parkinson's, and CAG triplet repeat diseases. In the first chapter, Bill Klein reviews the role of A~ toxicity in the patho- physiology of Alzheimer's disease. This controversial issue is further exam- ined in the context of transgenic models of Alzheimer's disease by LaFerla and colleagues. Sue Griffin and Robert Mrak, and Caleb Finch and collabora- tors, then examine the role of glial cells and inflammation in Alzheimer's disease; a review of the role of proteolysis in the generation of abnormal pro- tein fragments by Hook and Mende-Mueller follows. Therapeutic opportuni- ties offered by a better understanding of Alzheimer's disease pathophysiology are examined by Perry Molinoff and his colleagues at Bristol-Myers Squibb.

Foods and Dietary Supplements in the Prevention and Treatment of Disease in Older Adults focuses on the ways in which food and dietary supplements affect the major health problems of aging adults. Researchers in nutrition, diet, epidemiology, and aging studies, as well as healthcare providers who work with elderly patients will use this comprehensive resource as a tool in their long-term goal of preventing and treating chronic disease within the elderly. This book brings together a broad range of experts working on the different aspects of foods and dietary supplements (vitamins, herbs, plant extracts, etc.) in health promotion and disease prevention. They have contributed chapters which define a range of ways in which foods, nutriceuticals, and dietary supplements prevent disease and promote health in older adults. They begin by reviewing the medicinal role of foods, herbal, and dietary supplements in health promotion in older adults, as well as some of the most commonly used supplements in elder "self-medication." They review the most recent studies of how foods, herbal, and dietary supplements are effective in the prevention and treatment of cancer, cardiovascular disease, diabetes, and other obesity associated diseases in older adults. Then they consider alcohol, other drugs, and plant based drugs of abuse which can adversely affect the health of older adults. Lastly, they consider foods and dietary supplements in gene regulation in older adults.

This book reviews how mathematical and computational approaches can be useful to help us understand how killer T-cell responses work to fight viral infections. It also demonstrates, in a writing style that exemplifies the point, that such mathematical and computational approaches are most valuable when coupled with experimental work through interdisciplinary collaborations. Designed to be useful to immunoligists and viroligists without extensive computational background, the book covers a broad variety of topics, including both basic immunological questions and the application of these insights to the understanding and treatment of pathogenic human diseases.

The fields of rare diseases research and orphan products development continue to expand with more products in research and development status. In recent years, the role of the patient advocacy groups has evolved into a research partner with the academic research community and the bio-pharmaceutical industry. Unique approaches to research and development require epidemiological data not previously available to assist in protocol study design and patient recruitment for clinical trials required by regulatory agencies prior to approval for access by patents and practicing physicians.

Various foods, herbs and spices are used to treat or prevent disease and there have been considerable advances in scientific techniques over the last few decades. These have been used to examine the composition and applications of traditional cures. Modern science has also seen the investigation of herbs, spices and botanicals beyond their traditional usage. Contributions are from leading national and international experts including those from world renowned institutions. Please target oncologists, cancer specialists, physicians, health scientists, healthcare workers, pharmacologists, and research scientists. The audience also includes federal and state program directors. It is valuable to academic libraries that cover the domains of health and medical sciences. It is also suitable for undergraduates, postgraduates, lecturers, and academic professors.

Clinical Management of Renal Transplantation presents The Belfast City and University Hospital experience in renal transplantation. Over the years, the Belfast Renal Transplant Unit has acquired considerable experience in all aspects of renal transplantation which have led to excellent results. The team working in the Belfast Renal Transplant Unit has built up an outstanding reputation which has become widely known. This volume is a comprehensive, practical reference work for senior medical students and nurses as well as for the established nephrologist and transplantation surgeon. It provides a clear and concise picture of the care needed by patients who are being prepared for renal transplantation or who have recently received a kidney transplant.