A reporter uncovers the secrets behind the scientific scam of the century. The news breaks first as a tale of fear and pity. Doctors at a London hospital claim a link between autism and a vaccine given to millions of children: MMR. Young parents are terrified. Immunisation rates slump. And as a worldwide 'anti-vax' movement kicks off, old diseases return to sicken and kill. But a veteran reporter isn't so sure, and sets out on an epic investigation. Battling establishment cover-ups, smear campaigns, and gagging lawsuits, he exposes rigged research and secret schemes, the heartbreaking plight of families struggling with disability, and the scientific deception of our time. Here's the story of Andrew Wakefield: a man in search of greatness, who stakes his soul on big ideas that, if right, might transform lives. But when the facts don't fit, he can't face failure. He'll do whatever it takes to succeed.

The second edition of "Syncope: Mechanisms and Management" has been completely updated and revised and remains the most comprehensive textbook ever published on this common clinical entity. It provides up-to-date coverage of virtually every known cause of syncope, integrating knowledge of pathophysiology with practical guidelines for diagnosis and management. Incorporating clinical, investigative and experimental work conducted by leading authorities from all over the world, this book will serve as a practical resource for practicing cardiologists, electrophysiologists, neurologists, internists, pediatricians, and family physicians, as well as residents and fellows in these disciplines.

Great American Diseases: Their Effects on the Course of North American History presents medical history as it pertains to the major infectious diseases of North America. The book is designed to provide an interesting and engaging introduction to microbiology, immunology and epidemiology. With the advent of COVID-19, this book will serve as a reference on the history of previous epidemics. The book presents pandemics in an easy-to-read volume and provides concise chapters on the history of a disease, progression of understanding on the pathogen (agent of the disease), and their social ramifications through the history of North America.

This selection of articles from the Encyclopedia of the Eye covering retina, optics/optic nerve and comparative topics constitutes the first reference for scientists, post docs, and graduate students with an interest beyond standard textbook materials. It covers the full spectrum of research on the retina - from the basic biochemistry of how nerve cells are created to information on neurotransmitters, comparisons of the structure and neuroscience of peripheral vision systems in different species, and all the way through to injury repair and other clinical applications.

*The first single volume to integrate comparative studies into a comprehensive resource on the neuroscience of the retina

*Chapters are carefully selected from the Encyclopedia of the Eye by one of the world's leading vision researchers

*The best researchers in the field provide their conclusions in the context of the latest experimental results

Understanding how digestive organs develop, their physiology and structure is important for determining new therapies to combat diseases of the digestive organs. This volume reviews the latest research and developments in this field.

* Discusses new discoveries, approaches, and ideas * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields

Cancer is a leading cause of death among adults. Although about 250f Americans develop cancer in their lifetime, in some populations this rate has been reduced by lifestyle changes. Increasing numbers of people are turning to the use of dietary vegetables, medicinal herbs, and plant extracts to prevent or treat cancer. Their ready availability as "over the counter" supplements has contributed to an explosion in the use of herbal extracts and related compounds for health enhancement.

The spectacular growth of the multi-billion dollar functional food and nutraceutical business, touting health claims sometimes based upon limited research data, underscores the need for this up-to-date reference. "Functional Foods and Nutraceuticals in Cancer Prevention" brings together a leading group of experts on the different aspects of nutrient supplementation, foods, and plant extracts in cancer prevention and treatment. Their conclusions and recommendations present the most current knowledge from which to springboard future research and create a scientific database for accurate health claims.

. This up-to-date resource is a must-have for research professionals, both basic and applied, and marketers in the worldwide functional foods/nutritional supplements industry. It is an essential reference for hospital-based dietitians and nutritionists, physicians specializing in oncology, and cancer researchers. Food and drug officials who determine allowable health claims need this information as well, as do academics in all of these fields

This ground-breaking book brings together scholars from the humanities and social and physical sciences to address the question of how recent work in the genetics, zoology, and epidemiology of plague's causative organism (Yersinia pestis) can allow a rethinking of the Black Death pandemic and its larger historical significance. This book is available as Open Access.

Get the tools and knowledge you need for effective diagnosis, evaluation, and management of patients with acute myocardial infarction. Myocardial Infarction: A Companion to Braunwald's Heart Disease, by David A. Morrow, MD, is a comprehensive, hands-on resource that provides practical guidance from a name you trust. Concise and easy to use, this text explores the most recent tools for diagnosis and therapeutic decision-making, as well as the full range of available management strategies, providing outcomes data for each strategy. Myocardial Infarction also includes regular updates with late-breaking clinical trials, reviews of important new articles, and the latest guidance on clinical practice, all selected and masterfully edited by Dr. Eugene Braunwald. Provides thorough discussions of ECG, established and emerging biochemical markers, angiography, nuclear cardiology, echocardiography, and cardiac MRI and CT. Features an extensive treatment section that covers the latest drugs and most recent clinical trials of antiplatelet therapy, coronary revascularization, gene therapy, and approaches to reperfusion injury and ventricular remodeling. Discusses special considerations for the evaluation of acute coronary syndromes in the emergency department, and use of advanced technologies in cardiac critical care. Covers key topics such as in-hospital complications, cardiogenic shock, transitions to post-discharge care, and cardiac rehabilitation. Includes Clinical Practice/Controversy chapters that highlight management-focused, practical topics covering expert approaches for areas of uncertainty. Offers guidance on the management of special populations. Online content includes animations illustrating key pathobiology, including dynamic thrombosis, platelet adherence-activation-aggregation and adverse ventricular remodeling, as well as management strategies and procedural techniques. Regularly updated Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

This title includes proceedings of the 3rd European Congress on Obesity, Nice, France, 1991.

Over 50% of known flaviviruses have been associated with human disease. The "Flavivirus" genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat.
Detection, Diagnosis and Vaccine Development, the third volume of The Flaviviruses details the current status of technologies for detection and differentiation of these viruses, their use in surveillance and outbreak investigation, and also reviews the latest clinical research.
* Comprehensive approach to the scientific disciplines needed to unravle the complexities of virus-host interactions
* Descibes the technologies that have contributed to our current knowledge about the Flaviviruses
* Identifies the major problems faced in understanding the virus-host interactins that result in disease
* An exhaustive compendium of current and past knowledge on the Flavivirus family

The only book on the market that combines friendliness and visual appeal with complete guidance on managing both type 1 and type 2 diabetes.

If you or a loved one is living with type 1 or type 2 diabetes, you need this friendly guide to managing health, diet, physical activity, and treatment. This book is packed with simple, easy-to-understand explanations of how diabetes works and practical, positive advice for preventing or living with it. Illustrated in full colour throughout, it includes step-by-step illustrated sequences, flowcharts, and diagrams. Routines such as how to monitor and control blood glucose are explained in the clearest possible way. Find out how the types of diabetes differ, what signs to look out for, how to care for children with diabetes, how to reduce the risk of long-term complications, what to do in emergencies, and how to stay motivated and positive.

The Diabetes Handbook will help you make successful lifestyle choices to promote health, be active, eat healthily, and thrive, not just survive.

A complete guide to the side-effects and treatments - both conventional and alternative - for endometriosis, from a respected name in the field who also suffers from endometriosis.

Endometriosis is a debilitating reproductive and immunological disease that affects 7-10 million American women each year. The disease occurs when the same kind of tissue that lines the walls of the uterus grows outside the uterus in the pelvic cavity or some other area of the body, usually significantly affecting the woman's fertility and often causing pelvic pain. And as with any condition that affects fertility, the results are often emotional and psychological as well as physical.

As someone who suffers from endometriosis, and who has connections to a wide network of healthcare professionals, Morris is the perfect person to guide sufferers through diagnosis, treatment and living well with the condition. Like the previous titles in our successful Living Well series, this book will offer a holistic approach to living with the disease. The author will offer strategies for coping with the psychological aspects of endometriosis, including how best to tell others about the condition; treatment options including alternative and complementary treatment plans; dealing with infertility; and weighing the hysterectomy option. The author will draw on her relationship with fellow sufferers as well as medical professionals to help readers, making this the most comprehensive guide to endometriosis available.

Kerry-Ann Morris was diagnosed with endometriosis in 1999. Since then she has become one of the most active members of the endometriosis community, and has started an outreach website for the disease.She has relationships with many fellow sufferers and experts in the medical community, making her the perfect author for a book on holistic treatment.

The importance of appropriate and effective management of patient with long term chronic conditions cannot be underestimated, and both the Department of Health and the public are expecting much from the improvements and changes outlined in the recently published review by Lord Darzi.
"Case Management of Long Term Conditions" aims to provide all appropriate practitioners across all the professions (nurses, pharmacists, physiotherapists including social care practitioners) who might be involved in delivery of proactive case management with a practical understanding of how their knowledge and skills can be utilised to improve outcomes for people with Chronic Long Term Conditions. The text contains some broad reflections on care and service delivery based on reviews of evidence and views from clinicians in the use of these skills and competencies to deliver improved outcomes for these clients.

Metabolic bone degeneration (osteoporosis) affects millions of people--primarily postmenopausal women--and is directly responsible for debilitating hip, vertebral, and limb fractures in the elderly. Incorporating advances made within just the past five years, The Osteoporotic Syndrome: Detection, Prevention, and Treatment serves as an up-to-date, practical guide to the major clinical aspects of osteoporosis. The text is liberally illustrated with detailed figures.
As a resource for the clinician dealing with metabolic bone degeneration, this book represents an excellent source of information on the diagnosis and day-to-day management of osteoporosis.
Topics covered include
* Therapy with Vitamin D metabolites, sodium fluoride, thiazides, and isoflavones
* Biochemical markers of bone turnover
* Calcium, Vitamin D, and bone metabolism
* Estrogens and tissue selective estrogens for prevention and treatment of osteoporosis
* The effects of osteoporosis on orthopaedic surgery
* The therapy of glucocorticoid bone disease
* Effects of aging on bone structure and metabolism
* Management of osteoporotic patients in our health care delivery system
* The genetics of osteoporosis
* Bisphosphonate therapy for osteoporosis
* Calcitonin
* Bone mass measurement techniques in clinical practice
* Osteoporosis and the bone biopsy

This book is an introductory text to spinal disorders. Based on the highly successful forerunner to this volume, Practical Orthopaedic Medicine, the book still retains the original philosophy of this text which is to systematically cover all the joints discussing examination, diagnosis and treatment. The full spectrum of therapies is covered with particular emphasis on Maitland's widely practised spinal manipulation techniques - how they are assessed clinically and their role in the management of spinal problems. A complete review of the current literature has been undertaken and a valuable new chapter on the spine in sport has been added. This book will be essential reading for students and practitioners involved in sports medicine, orthopaedic medicine and physiotherapy.

This text highlights the value of a team approach to appreciating the commplexity of spinal pain and a range of treatment approaches. Contributions from epidemiology, anatomy, pathology, biomechanics, clinical medicine orthopaedics, chiropractic, osteopathy and physiotherapy are presented. Each section is written by an experienced practitioner and provides a summary of pertinent material, seeking to improve the reader's understanding of the causes of cervical spine pain The volume is part of a series of three books bringing together a multidisciplinary approach to the management of mechanical spinal pain.

Metabolic Bone Disease, Third Edition is the new, expanded edition of the classic text, featuring the latest advancements and research information in this fast-moving field. The Third Edition includes the most up-to-date information on molecular mechanisms, basic biology, pathophysiology, and diagnosis and management strategies of metabolic bone disease.
Key Features
* Edited by "fathers of the field"
* An expanded version of a classic AP text
* Complete coverage of a fast-growing field

Atrial fibrillation is a heart condition that causes an irregular and often abnormally fast heart rate. It can cause problems including dizziness, shortness of breath and tiredness and a patient may be aware of noticeable heart palpitations, where the heart feels like it is pounding, fluttering or beating irregularly, often for a few seconds or, in some cases, a few minutes (NHS Choices). This comprehensive guide presents clinicians with the latest developments in the diagnosis and management of atrial fibrillation. Divided into seven sections, the book covers clinical spectrum, diagnosis, therapeutic strategies, interventions, and new technologies used in its treatment and prevention. Complete sections are dedicated to other arrhythmias, to cardiac surgery and to future directions in atrial fibrillation. With more than 1000 pages providing in depth coverage of the topic, this manual is further enhanced by clinical photographs, diagrams and tables. Key Points Comprehensive guide to latest developments in diagnosis and treatment of atrial fibrillation More than 1000 pages discuss clinical spectrum, diagnosis, treatment options, interventions, and new technologies Complete sections dedicated to other arrhythmias, cardiac surgery, and future directions Highly illustrated with clinical photographs, diagrams and tables

'Billy Connolly says he's no idea who Parkinson was and just wishes he'd kept his disease to himself. He should read this book.' Jeremy Paxman Parkinson's disease is one of the most common forms of dementia, with 10,000 new cases each year in the UK alone, and yet few know anything about the man the disease is named after. In 1817 - exactly 200 years ago - James Parkinson (1755-1824) defined the disease so precisely that we still diagnose it today by recognising the symptoms he identified. The story of this remarkable man's contributions to the Age of the Enlightenment is told through his three passions - medicine, politics and fossils. As a political radical Parkinson was interrogated over a plot to kill King George III and revealed as the author of anti-government pamphlets, a crime for which many were transported to Australia; while helping Edward Jenner set up smallpox vaccination stations across London, he wrote the first scientific study of fossils in English, which led to fossil-hunting becoming the nation's latest craze - just a glimpse of his many achievements. Cherry Lewis restores this neglected pioneer to his rightful place in history, while creating a vivid and pungent portrait of life as an 'apothecary surgeon' in Georgian London.

Vitamin D deficiency, circulating levels lower than 15 ng/ml, is an epidemic disease worldwide with more than a billion people suffering of it in the beginning of the 21-century. Besides its impact on mineral and bone metabolism, these low vitamin D levels are also associated with a diversity of non-skeletal complications, among them cardiovascular disease, diabetes mellitus, multiple sclerosis, cancer, tuberculosis, and immune system dysfunction. Chronic Kidney Disease is also a very common disease, affecting more than 10% of the world population, ranging from stage 1 to stage 5 before dialysis. Approximately 1% of the population in industrialized countries is affected by end-stage renal disease (ESRD), needing a renal replacement therapy either hemodialysis or peritoneal dialysis, and ultimately by renal transplantation. Those CKD patients are more susceptible to exhibit reduced vitamin D stocks. Consequently, more than eighty percent of CKD patients have either insufficient or deficient vitamin D levels for multiple reasons.

Noncommunicable diseases (NCDs) - including cardiovascular disease, diabetes, asthma and other chronic respiratory conditions, and cancers - are the leading causes of death worldwide. An estimated 36 million people die from such diseases each year; this represents roughly two out of three deaths globally. Eighty percent of these fatalities occur in developing countries. The statistics are staggering, yet millions of these deaths are preventable. This is an urgent global health issue that demands analysis of gaps in NCD research, new policies and practices, and actionable recommendations to close the gaps. The Johns Hopkins Institute for Applied Economics, Global Health, and the Study of Business Enterprise convened an NCD Working Group of leading scholars to examine a wide range of issues that both the private and public sectors must address to make sustainable progress in NCD prevention and treatment in lower- and middle-income countries. Collected in this volume are essays on five key areas where strengthened policies and health systems can have the most impact in the near future. Features: accelerating regulatory harmonization; structuring supply chains; improving access to interventions; restructuring primary care; and promoting multisectoral and intersectoral action. While there is a growing literature on the problem of NCDs, none of the available studies provides background on the range of challenges matched with specific steps that can be taken by the public sector, private sector, and civil society working together. Noncommunicable Diseases in the Developing World presents a framework for understanding the salience of specific policy recommendations and detailed steps that can be taken now to move forward in the global campaign against NCDs. This book will be of interest to practitioners, scholars, and students in public health as well as those framing and implementing health policies in the private and public sectors.