Like the successful first edition, this improved, updated and expanded second edition covers the presentation of the common orofacial disorders and a wide range of less common and some rare disorders. It also now includes treatment recommendations for the most common oral diseases, tailored to the pediatric age group.

Any health professional called upon to diagnose and treat children who have orofacial problems will benefit from the wealth of material offered here.

Stresses molecular and biochemical studies of opportunistic and frank fungal pathogens
This book gives a comprehensive overview of human pathogenic fungi that offers a current and concise survey of virulence factors, host responses and recognition, treatment and diagnosis of infections, invasive enzymes, intracellular survival, morphogenesis, adaptation, and properties of major fungal pathogens that contribute to disease.
Focuses on human fungal infections, including candidiasis, pneumocystosis, aspergillosis, and cryptococcosis.
With over 3700 references to accommodate continuing study, Fungal Pathogenesis
covers natural and acquired immunity, vaccine development, and immune reconstitution
outlines rapid identification of major mycoses utilizing antigen capture and molecular assays
details signaling and phenotypic switching
discusses the value of genomics in validation
highlights state-of-the-art molecular methodologies to study disease-causing organisms
describes available and potential antifungal drug targets and drug development
considers predicting the consequences of drug resistance on patient management
presents topical observations on strain typing and variation
and more
Containing research into the virulence, immunity, diagnosis, and therapy of most common fungal infections, Fungal Pathogenesis is an unparalleled reference for microbiologists, virologists, pathologists and phytopathologists, infectious disease specialists, molecular and cell biologists, biochemists, immunologists, medical mycologists, biotechnologists, and geneticists, and an exceptional text for upper-level undergraduate, graduate, and medical school students in these disciplines.

Individuals with serious and persistent mental illnesses, including schizophrenia and affective disorders, often experience cognitive deficits that make it challenging to perform everyday tasks. For example, they may have difficulty paying attention, remembering and learning, thinking quickly, and solving problems, and this may interfere with functioning at work, school, and in social and living situations. Cognitive remediation is an evidence-based behavioral treatment for people who are experiencing cognitive impairments that interfere with role functioning. Cognitive Remediation for Psychological Disorders contains all the information therapists need to set up a cognitive remediation program that helps clients strengthen the cognitive skills necessary for everyday functioning. The program described is called Neuropsychological and Educational Approach to Remediation (NEAR), an evidence-based approach that utilizes carefully crafted instructional techniques which promote learning. The goals of NEAR are to provide a positive learning experience and to promote independent learning and optimal cognitive functioning in daily life. The second edition of this popular Therapist Guide provides step-by-step instructions on how to implement NEAR techniques with patients. Guidelines for setting up and running a successful cognitive remediation program are laid out in an easy-to-follow format. Therapists will learn how to choose appropriate cognitive exercises, recruit and work with clients, perform intakes, and create treatment plans. This Guide comes complete with all the tools necessary for facilitating treatment, including program evaluation forms and client handouts.

This book describes our current understanding of the transport of ions, amino acids, nucleosides, sugars, water and gases across the red blood cell membrane. It also outlines the necessary theoretical background to understand the dynamics of membrane constituents together with the mechanisms of transport pathways (pumps, channels, carriers/cotransporters, residual passive permeability). Separate chapters describe our present ideas about membrane and metabolic disorders as well as red blood cell diseases like malaria, sickle cell disease, and hypertension. The latest findings are explained on the basis of well-established principles. The book and its chapters are thus structured in a manner that makes the material accessible to beginners in the field of red blood cell physiology and biophysics. Active researchers will also benefit from this carefully organized compilation. 51 worldwide leading experts in the field of erythrocyte research contributed to the 31 chapters of this book.

This detailed volume presents a series of protocols that are representative of recent developments and improvements in induced pluripotent stem cells (iPS cells) and corresponding human disease models. Reflecting the latest technology for generating induced pluripotent stem cells (iPS cells) and their initial characterization, the book explores techniques invaluable both for studies of disease-specific cell types and for their potential applications in regenerative medicine. Written for the highly successful Methods in Molecular Biology series, chapters include introduction to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Induced Pluripotent Stem Cells and Human Disease: Methods and Protocols serves as a vital guide that is valuable for not only experts but also novices in the stem cell field.

Learn to handle the problems that Parkinson's patients face
Through Parkinson's Disease and Quality of Life, you will discover common problem areas seen in patients with Parkinson's disease. This book explores problems that interfere with functional independence of patients and gives examples of occupational therapy intervention and treatment techniques. Parkinson's Disease and Quality of Life boldly deals with many seldom talked about real-life issues facing people with Parkinson's disease, including continued sexual intimacy and urinary incontinence. Although these issues may not be curable, this book provides you with effective treatments through data and case studies.
Parkinson's Disease and Quality of Life offers caregivers a step-by-step plan to get organized. It includes a plan to put together a workbook of all relevant information, as well as tips on how to safeguard every room for a Parkinson's disease patient. This book helps remind you that the families of the patient must not be forgotten and that they can get the help they need through support groups, community resources, and from professional staffing such as nurses and aides. Parkinson's Disease and Quality of Life will assist you in helping your patients by:

• using music therapy to help calm patients
• realizing the legal impact of Parkinson's disease by discussing living wills, health care proxies, durable power of attorney, and revocable and irrevocable trusts with your clients
• discovering that cognitive changes, dementia, and depression can complicate the treatment of the disease and be more disabling than the loss of motor function
• exploring the nursing home as a viable options for clients as well as their families

This book examines the technologies and processes for the development and commercial production of stem cells according to cGMP guidelines. The initial chapter of the book discusses the therapeutic potentials of stem cells for the treatment of various diseases, including degenerative disorders and genetic diseases. The book then reviews the recent developments in the cultivation of stem cells in bioreactors, including critical cultural parameters, possible bioreactor configuration and integrations of novel technologies in bioprocess developmental stages. The book also introduces microscopic, molecular, and cellular techniques for characterization of stem cells for regulatory approvals. Further, it describes optimal cell transporting conditions to maintain cell viability and properties. Further, it summarizes characterization strategies of clinical grade stem cells for stem cell therapy. This book is an invaluable contribution to having an academic and industrial understanding with respect to R&D and manufacturing of clinical grade stem cells.

Syringobulbia offers neurologists a thorough discussion of the disease and the literature on it-- brought up to the present. In addition, the book presents a number of case studies--valuable because they trace the course of the disease from initial presentation to death.

Dr. Jay A. Goldstein 's Betrayal by the Brain can be a daunting treatise to the layperson as well as a challenge for the physician who is not versed in neurology, psychiatry, immunology, and endocrinology. Here, in A Companion Volume to Dr. Jay A. Goldstein 's Betrayal by the Brain: A Guide for Patients and Their Physicians, Author Katie Courmel, a longtime sufferer of chronic fatigue syndrome and fibromyalgia, presents in layperson 's terms the salient points of the book to lead readers to an understanding of Dr. Goldstein 's theory and methods of treatment. This guide provides CFS and FMS patients with an understanding of how their brains should function as opposed to how they are now dysfunctioning. It explains the proper role and function of each brain structure and neural assembly and the neurochemicals believed to be implicated in CFS and fibromyalgia along with the dysfunctions found in CFS/FMS patients. These dysfunctions, as a whole, form the basis of Dr. Goldstein 's unified theory behind the possible causes of CFS and FMS. Patients involved in or contemplating Dr. Goldstein 's treatment can use A Companion Volume to Dr. Jay A. Goldstein 's Betrayal by the Brain to gain an explanation of the process from a firsthand perspective and can follow along to learn why they are given particular drugs and what response Dr. Goldstein hopes to elicit from their bodies. This understanding gives patients a sense of control and helps them weather the ups and downs their bodies experience as a normal response to the treatment. The strength of A Companion Volume to Dr. Jay A. Goldstein 's Betrayal by the Brain lies in its ability to simplify without sacrificing the body of information that one must understand to make sense of the multitude of seemingly unrelated manifestations of these diseases of the brain. A thorough understanding will allow sufferers of CFS/FMS to approach Dr. Goldstein 's treatment method with an open mind and improve their chances for success. Specific questions answered for readers include: how safe is this protocol? should I go alone or take a companion? what should I expect during my initial consultation? what are the effects of so many drugs? why doesn t the same drug work for everyone? if my treatment is successful, how long will it last? what happens when I leave Dr. Goldstein 's care? A Companion Volume to Dr. Jay A. Goldstein 's Betrayal by the Brain prepares readers for a unique, sometimes scary, often perplexing, hopefully miraculous, leap-of-faith experience. It helps patients deal with the very natural sense of uneasiness they may be feeling and helps them understand, in layperson 's terms, what Dr. Goldstein 's protocol can accomplish and how it can be so successful.

The autoimmune thyroid diseases and familial thyroid cancers are the current target of molecular thyroid genetics. Unlike the situation in monogenic thyroid diseases, for which the molecular genetics has largely been clarified over the past 20 years, a methodological approach to these more complex forms of thyroid disease has not yet been well established. The determination of susceptibility genes, for example, remains a major challenge. The contributors to this volume are attempting to meet that challenge in research on molecular genetics. Meeting at the first International Symposium on the Genetics of Complex Thyroid Diseases, held in Kyoto, Japan, 20 distinguished researchers from five countries in addition to Japan shared their latest results and engaged in intense discussion, focusing on the autoimmune thyroid diseases and familial thyroid cancers. Their papers collected here are a valuable contribution to the field of the genetics of complex thyroid diseases.

This work presents an examination of Crohn's disease (CD), from an historical evaluation of the field to future developments of aetiopathogenesis, diagnostic evaluation and therapeutic management. It reviews possible aetiologic agents, the various ways in which CD progresses, novel diagnostic techniques and standard and innovative therapies. The application of recent advances in basic research to clinical management of the disease is emphasized.

The harmful consequences of alcoholism for the unborn child are still largely unknown. This book presents a detailed description of fetal alcohol syndrome as well as fetal alcohol spectrum disorders with respect to their clinical presentation, diagnosis, epidemiology, and pathogenesis. It also includes detailed considerations of underlying psychopathology, prevention, and therapy as well as the social consequences and impacts to patients.

Constipation and incontinence are of considerable importance to a great number of patients but many put it under taboo. Both functional disturbances comprise a wide spectrum of pathophysiological findings of neuro-muscular changes of the colon or the pelvic floor, but psychological factors may play an important role as well. In recent years much progress has been made in several disciplines which are important for the understanding and handling of constipation and incontinence. This volume, the proceedings of Falk Symposium No. 95 held in Freiburg, Germany, October 28-30, 1996, concentrates on clinically relevant and open questions rather than trying to cover the whole field in all details.

Emphasizing the clinical problems surrounding urogenital tract dysfunction, this up-to-date reference details the basic science, differential diagnosis, and treatment of a wide range of neurourological conditions.
Covering recent advances in the neurobiology of the pelvic organs, the Handbook of Neuro-Urology
reviews the neural control processes that govern pelvic organs
discusses the pathogenic mechanisms behind neurological and smooth muscle disorders that produce bladder dysfunction
describes the management of impaired bladder, bowel, and sexual function after brain damage and spinal cord injury
examines various conditions that affect the autonomic nervous system and specifically result in bladder and sexual dysfunction
investigates lower urinary tract function in the elderly
suggests practical measures to manage urinary incontinence such as the use of pads, underpants, and appliances
and more!

The mechanistic basis of chronic inflammation remains unclear. The research sheds new light on the immune cells expressing the activation markers HLA-DR and regulatory T cells (Tregs) and the cells expressing Siglec receptors as being key players in the immune system responsiveness to antigens and thus in lung tissue damage of chronic inflammation. The results help understand the mechanisms of action of common drugs used in COPD, such as formoterol, tiotropium, or corticosteroids, and point to novel drug targets. The chapters also deal with brain damaging effects, by far unrecognized, of inhaled corticosteroid therapy, a time-proven management of chronic inflammatory airway conditions; asthma being a case in point. Novel methods, likely less producing side effects, of macrolide antibiotics administration by inhalation are discussed, emphasizing not only bacteriostatic but also anti-inflammatory action.

Somatic psychology and bodymind therapy (the simultaneous study of the mind and body) are challenging contemporary understandings of the psyche, of what it means to be human and how to heal human suffering. This book discusses these areas of study.

This thoughtful new book presents strategies for helping end-stage renal disease patients and their families deal with the psychosocial aspects of the chronic long-term illness. Technological advances in the treatment of this disease have offered much hope for improved quality in living which has led caregivers to have a greater concern for preserving the quality of life of their patients. In Psychosocial Aspects of End-Stage Renal Disease leaders in the field of many disciplines share knowledge and reveal problems that are still evident to them in the confrontation with this potentially fatal illness.Five comprehensive sections devote special attention to the different areas of concern for the psychosocial well-being of end-stage renal disease patients. The impact of renal disease on family relationships is covered by examining issues of family responses and coping measures such as marital and family reactions to home and hospital dialysis treatment. Ethical issues in treatment are explored, including the ethics of treatment refusal and a Jewish perspective on kidney transplants. Relations between staff and patients and a timely section on renal disease and special populations, particularly the elderly and AIDS patients, make up the final two sections of this informative volume. Professionals in all allied health disciplines will benefit from this important volume as it demonstrates a model approach, if not the definitive one, for the treatment of the psychosocial aspects of end-stage renal disease as well as other chronic illnesses.

The authors introduce readers to some common germs that are very likely residing in their bodies. They explain how these infections cause a chronically elevated cortisol level with all its negative effects, eventually leading to the potbelly syndrome. It explains what steps readers can take to protect themselves. The authors also address other causes of high cortisol levels, since these contribute even further to ill health. The book clarifies the cause of hypercortisolism so that readers can do something about it.

In this unique title, the full range of chronic respiratory conditions and their association with psychiatric comorbidities are explored and targeted management options are outlined. Indeed recent studies indicate a far higher prevalence of depression and anxiety in patients afflicted with chronic respiratory conditions than in patients with other chronic disorders. Unlike other publications in the field of pulmonary disease, Depression and Anxiety in Patients with Chronic Respiratory Diseases details this significant correlation. The book is comprehensive in scope, covering such topics as depression and anxiety across the age spectrum, diagnostic tools for anxiety and depression, anxiety and depression in COPD patients, depression and anxiety in adult patients with asthma, and end-stage lung disease and lung transplantation, among others. In this novel work, the volume Editors enlist a team of renowned experts in the fields of respiratory and psychiatric disorders to combine a thorough synthesis of the literature with targeted, practical strategies for management. Depression and Anxiety in Patients with Chronic Respiratory Diseases is an invaluable resource for all clinicians who care for patients with chronic and advanced lung diseases.

Now that Helicobacter pylori is generally accepted as a key aetiological agent in gastric cancer as well as the main agent in peptic ulcer, it can claim to be the most important new discovery in clinical gastroenterology of the last decade, and yet there is no up-to-date book available on the subject that is designed primarily for the clinical gastroenterologist. This book aims to fill that niche. It should also be of interest to the basic scientist, to those providing a clinical laboratory service (microbiologists and histopathologists), and to epidemiologists and others involved in clinical research.