Investigating Human Diseases with the Microbiome: Metagenomics Bench to Bedside is a summary of underlying principles for human health and disease studies from a microbiome point-of-view. From birth to old age, microbiomes in fecal, oral/nasal, vaginal, and skin samples contain important information that can predict disease risks in the future. Tissue samples also contain microbes that are relevant for diseases. The microbiome connects genetic and environmental factors and is poised to greatly facilitate precision medicine, including prevention, diagnosis and effective treatment of many complex diseases. Based in traditional microbiology and adding a more wholistic view of the advent of high-throughput sequencing, this reference poses the key questions of the total number of microbial cells and their distribution in the human body while also considering concepts from macroecology and from causal reasoning. An entire chapter is dedicated to methods, providing hands-on information for important considerations when collecting samples for metagenomic studies.

Sjoegren's syndrome is a chronic autoimmune disease which can cause debilitating fatigue and pain. Diagnosis is often challenging due to the variability of symptoms and severity, and a multidisciplinary approach to management and treatment is required, yet there are few comprehensive resources covering everything clinicians need to know. The Oxford Textbook of Sjoegren's Syndrome bridges this gap by offering extensive coverage of system by system manifestations and treatments, as well as practical, evidence-based advice on diagnosing and managing this condition. Bringing together recent advances in research and therapies, this up-to-date guide covers everything clinicians need to know from the fundamental science and clinical characteristics of this condition, to the immunological and biochemical aspects, investigative procedures such as biopsy techniques and imaging modalities, and pharmacological and non-pharmacological interventions.

Fly Models of Human Diseases provides users with a comprehensive survey on fly models of human diseases in the field of developmental biology. It is ideal for researchers in animal and plant development, and for students and professionals working in a variety of fields related to the topic.

This book is an introductory text to spinal disorders. Based on the highly successful forerunner to this volume, Practical Orthopaedic Medicine, the book still retains the original philosophy of this text which is to systematically cover all the joints discussing examination, diagnosis and treatment. The full spectrum of therapies is covered with particular emphasis on Maitland's widely practised spinal manipulation techniques - how they are assessed clinically and their role in the management of spinal problems. A complete review of the current literature has been undertaken and a valuable new chapter on the spine in sport has been added. This book will be essential reading for students and practitioners involved in sports medicine, orthopaedic medicine and physiotherapy.

This text highlights the value of a team approach to appreciating the commplexity of spinal pain and a range of treatment approaches. Contributions from epidemiology, anatomy, pathology, biomechanics, clinical medicine orthopaedics, chiropractic, osteopathy and physiotherapy are presented. Each section is written by an experienced practitioner and provides a summary of pertinent material, seeking to improve the reader's understanding of the causes of cervical spine pain The volume is part of a series of three books bringing together a multidisciplinary approach to the management of mechanical spinal pain.

The onset of the quadruple burden of disease in South Africa, the challenges faced by the medical establishment to curtail the rapid growth of multiple epidemics, the inadequate response by the state to various inequities in the health system, and the public debates associated with it, have all combined to draw attention to the sociological aspects of health and disease. Sociology as a resource of knowledge and a unique analytical and conceptual perspective can be used to understand, explain and positively influence the course of health and disease in South African society and our responses to it. As a health practitioner or scholar you must be equipped with the skills to critically evaluate research and debates in your profession, be able to adapt to changes and contribute to the development of knowledge and best practice. This reader will familiarise you with relevant content and assist you to develop the analytical capacity and conceptual skills you will need. Society, Health and Disease in South Africa is authored by experienced educators and researchers in the fi elds of sociology, social work, anthropology, healthcare policy and practice.

Have you ever wondered what it is like to be dying? Knowing that you are within sight of reaching your own mortality? Sitting in a body that is not even recognised by your brain? Cilla knew! PSP (Progressive Supranuclear Palsy) affects thousands, yet there is little known about it. Perhaps the similarities between this illness and others have masked the effects, and for some this may come far too late due to misdiagnosis. This insight into the unique illness of PSP has been painstakingly put together for the exact purposes of showing how an illness can affect one person's life. The devotion to 'open up' in this frank, 'no holds barred' biography is to allow you, the reader, to see how an ordinary life can change in such a short time. This honest approach should allow both the sufferer and their eventual carers to help come to terms with both their illness and their own transience. Maybe, by proving how similar we all are, there might be an eventual understanding, which hopefully will go well beyond just one person. With the help of others, it has been possible to recall some human elements. Although, in truth, it is the sufferers own underlying feelings and personal memories that make this book so special. In this instance, like many of us, Cilla remembered what it felt like to be invincible. To be able to run, skip, hop, jump, climb and generally be able to do almost anything. Through this book, Cilla thought that if her experiences were made public then she could, at least, help othersa | indirectly or otherwise. The latter stages of the book, sadly, reflect the concluding stages of lifea | so be prepared to get to know Cilla in both life and her eventual death.

Bristol - 1953 It's Coronation Year. A new beginning in the aftermath of war, but there are still battles to be fought and secrets to be kept. Charlotte Hennessey-White copes with the shortcomings of her marriage and throws herself into helping refugees unwelcome by some and exploited by others. Edna Burbage has three beautiful children and considers herself lucky until the advent of a deadly twentieth century disease makes her think otherwise. Polly Chandler still hopes for a better life, but there are too many obstacles standing in her way. These three women lived through a war, can they now cope with the demands of peace? Praise for Lizzie Lane: 'A gripping saga and a storyline that will keep you hooked' Rosie Goodwin 'The Tobacco Girls is another heartwarming tale of love and friendship and a must-read for all saga fans.' Jean Fullerton 'Lizzie Lane opens the door to a past of factory girls, redolent with life-affirming friendship, drama, and choices that are as relevant today as they were then.' Catrin Collier 'If you want an exciting, authentic historical saga then look no further than Lizzie Lane.' Fenella J Miller

Great American Diseases: Their Effects on the Course of North American History presents medical history as it pertains to the major infectious diseases of North America. The book is designed to provide an interesting and engaging introduction to microbiology, immunology and epidemiology. With the advent of COVID-19, this book will serve as a reference on the history of previous epidemics. The book presents pandemics in an easy-to-read volume and provides concise chapters on the history of a disease, progression of understanding on the pathogen (agent of the disease), and their social ramifications through the history of North America.

Food selection plays an important role in ensuring pro- and anti-inflammatory balance. Certain foods are responsible for increasing inflammation while others have anti-inflammation properties. Western diets especially, rich in red meat, simple carbohydrates, and refined grains, increase the levels of pro-inflammatory markers, C-reactive protein (CRP), and interleukin-6 (IL-6). Additionally, short- and long-chain fatty acids, various micronutrients including zinc, selenium, iron, vitamin A, probiotics, and prebiotic foods affect inflammation. As inflammation can be linked to a variety of diseases, more studies are needed about nutrition and its ability to prevent inflammation. Role of Nutrition in Providing Pro-/Anti-Inflammatory Balance: Emerging Research and Opportunities is an essential publication that examines balancing inflammation through nutrition and nutritional strategies. Firstly, information about the formation process of inflammation, biomarkers used for diagnosis, diseases affected by inflammation, and their incidence in society are discussed. Subsequently, balancing inflammation in individuals through macro- and micro-nutrient consumption, nutritional supplements (probiotics and prebiotics), bioactive proteins and peptides, and dietary forms is examined. Featuring research covering a broad range of topics including food supplements, diet types, and bioactive proteins, this book is ideally designed for nutritionists, dieticians, clinicians, doctors, nurses, healthcare providers, researchers, academicians, and students.