Epilepsy has a fascinating history. To the medical historian Oswei Temkin it was 'the paradigm of the suffering of both body and soul in disease'. It is justifiably considered a window on brain function. And yet its story is more than simply a medical narrative, but one influenced also by scientific, societal and personal themes. Written for a medical and non-medical readership, this book describes the major developments in epilepsy between 1860-2020, a turbulent era in which science dominated as an explanatory model, medical theories and practices steered an erratic course, and societal attitudes and approaches to epilepsy fluctuated dramatically. In the middle of this maelstrom was the person with epilepsy at the mercy of social attitudes and legislation, and at times harmed as well as helped by medicine and science. So entangled is the history that intriguingly, as an entity, epilepsy may now be thought not even to exist.

Severe pain, debilitating fatigue, sleep disruption, severe gastrointestinal distress a" these hallmarks of chronic illness complicate treatment as surely as they disrupt patientsa (TM) lives, in no small part because of the overlap between biological pathology and resulting psychological distress. Cognitive Behavioral Therapy for Chronic Illness and Disability cuts across formal diagnostic categories to apply proven therapeutic techniques to potentially devastating conditions, from first assessment to end of treatment.

Four extended clinical case examples of patients with chronic fatigue, rheumatoid arthritis, inoperable cancer, and Crohna (TM)s disease are used throughout the book to demonstrate how cognitive-behavioral interventions can be used to effectively address ongoing medical stressors and their attendant depression, anxiety, and quality-of-life concerns. At the same time, they highlight specific patient and therapist challenges commonly associated with chronic conditions.

From implementing core CBT strategies to ensuring medication compliance, Renee Taylor offers professionals insights for synthesizing therapeutic knowledge with practical understanding of chronic disease. Her nuanced client portraits also show how individual patients can varya "even within themselves.

This book offers clinicians invaluable help with

- Conceptualizing patient problems

- Developing the therapeutic relationship

- Pacing of therapy

- Cognitive restructuring

- Behavioral modification

- Problem solving

- Fostering coping and adapting skills

Taylora (TM)s coverage is both clean and hands-on, with helpful assessments and therapyworksheets for quick reference. Cognitive Behavioral Therapy for Chronic Illness and Disability gives practitioners of CBT new insights into this population and provides newer practitioners with vital tools and tactics. All therapists will benefit as their clients can gain new confidence and regain control of their lives.

Outbreak: Cases in Real-World Microbiology, 2nd Edition, is the newest edition of this fascinating textbook designed for introductory microbiology students and instructors. Thoroughly revised, this collection of case studies of real-world disease outbreaks, generously illustrated in full color, offers material that directly impacts college-level students, while the book's unique presentation offers instructors the flexibility to use it effectively in a number of ways. More than 90 outbreak case studies, organized into six sections according to the human body system affected, illustrate the wide range of diseases caused by microbial pathogens. The studies are presented at differing levels of difficulty and can be taught at all undergraduate levels. Each case study includes questions for students to think about, discuss, and answer, and the book includes an appendix that directs students to the specific reference material on which each case was based, providing the opportunity to investigate further and to apply the reference content to the case being studied. Each of the six sections of the book concludes with a College Perspective and a Global Perspective case study. The College Perspective provides a direct and practical link between the microbiology course and the daily lives of students. The Global Perspective connects students with outbreaks that have occurred in countries around the world to facilitate understanding of the social, religious, economic, and political values at play in the treatment and prevention of infectious disease. At the end of every section, detailed descriptions offer concise yet complete information on each disease involved in that section.

A handy manual for cornea specialists, this book provides detailed practical information about a complex, sight-threatening disease that can be challenging to diagnose and manage. This text features chapters dedicated to outlining all facets of diagnosis and management while covering both medical and surgical treatment options. Peripheral Ulcerative Keratitis, supplemented with useful references and appendices to provide simple step by step algorithms, is written by internationally renowned authors who are experts in the field.Including practical tips and guidelines for diagnosis and therapy of these disorders, Peripheral Ulcerative Keratitis is designed to serve as a guide for comprehensive ophthalmologists and should find itself on the bookshelves of ophthalmology clinics, corneal practices and training programs across the country.

In the United States alone, roughly 300,000 children suffer from some form of arthritis or rheumatic disease, and millions more are at risk of developing one of these diseases. In this marvelously down-to-earth guide, Thomas Lehman--the head of one of the leading pediatric rheumatology programs in the world--offers a gold mine of expert advice invaluable for pediatricians who want to become more proficient in understanding, diagnosing, and treating rheumatic disease in children. Dr. Lehman helps pediatricians interpret their patients' complaints and determine whether and what type of medical attention is needed, explaining what symptoms to look for, what questions to ask, what tests to run, and what to expect when treatment begins. Using illustrative anecdotes, this book sheds light on a wide range of rheumatic disorders--including juvenile arthritis, Lyme disease, lupus, Kawasaki disease, fibromyalgia, and chronic fatigue syndrome--and it addresses such crucial topics as drug safety, genetic considerations, the potential risks to children posed by medications, the difficulty of family life when a child has a chronic disease, and much more.
A Clinician's Guide to Rheumatic Diseases in Children captures the expertise of a dedicated physician with over thirty years of hands-on experience helping children lead normal, happy lives. It will help pediatricians make sure that patients achieve the best possible outcome.

Now in paperback - Chris Wark's bestselling guide can help you beat cancer through a toxin-free diet and lifestyle and embark on your own journey towards wellness and healing. Millions of readers have followed Chris Wark's journey on his blog and podcast, and in Chris Beat Cancer, he dives deep into the reasoning and scientific foundation behind the approach and strategies that he used to successfully heal his body from stage III colon cancer. Drawing from the most up-to-date and rigorous research, as well as his deep faith, Chris provides clear guidance and continuous encouragement for his healing strategies, including his Beat Cancer Mindset; radical diet and lifestyle changes; and means for mental, emotional and spiritual healing. Packed with both intense personal insight and extensive healing solutions, this Wall Street Journal bestseller will inspire and guide you on your own journey.

Functional somatic syndromes are defined as physical syndromes without an organic disease explanation, demonstrable structural changes, or established biochemical abnormalities. This book reviews the state of scientific and clinical understanding of the nine most common functional somatic syndromes. For each syndrome, expert contributors provide a brief historical perspective, a current definition, a case presentation, confirmatory and contradictory research findings, a discussion of the leading pathogenetic hypotheses, and guidelines for diagnosis and treatment. Chapters offer advice for the determination of disability of patients with these medically unexplained disorders, while describing both medical and psychiatric interventions. Stressing the importance of a sound therapeutic relationship as a basis for treatment, this is an invaluable resource for professionals in primary care and many other disciplines.

In this up-to-date survey and critical assessment of transgenic and knockout models in neuropsychiatry and behavior, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond. The authors focus on transgenic and knockout models of neurocognitive dysfunction and neuropsychiatric dysfunction. The discussion of neurobiological problems covers mental retardation, polyglutamate, and speech disorders, as well as disorders that involve cognitive, social, speech, and language dysfunction. The neuropsychiatric dysfunctions examined include psychosis and schizophrenia, anxiety, depression, and bipolar disorder.

Medicinal Chemistry Approaches to Malaria and Other Tropical Disease, Volume 53 in the Annual Reports in Medicinal Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

The Motoneurone and its Muscle Fibres presents a state-of-the-art summary of knowledge concerning the motoneurones, vital for innervating and commanding skeletal muscles. No muscle action would be possible without motoneurones. These cells are therefore absolutely essential for the execution of normal behaviour and for life support. It is their degeneration that leads to various kinds of motoneurone disease (e.g. ALS) that are often ultimately lethal. However, the study of motoneurones is also important for general insights as to how neurones work, because the motoneurone is probably the best understood kind of nerve cell so far in neuroscience. Motoneurones of the spinal cord were the first type of central nerve cell to be subjected to detailed physiological measurements, and much is known about how their activity is regulated by synapses from other central neurones. For most of the individual neurones within the central nervous system, the precise functional tasks are difficult to define. However, for motoneurones much is now known about their short- and long-term interactions with their main targets, the skeletal muscle fibres. Functions of neurones must be analyzed in relation to the response properties of their target cells. Therefore, this book deals with both, summarizing classical as well as recent knowledge concerning the motoneurone and its muscle fibres. This is the first time that so many aspects of this broad subject matter are treated in one comprehensive monograph.

This book is an amalgamation of knowledge, experience, and expertise in various aspects of nanotechnology, by experts who are proficient in designing of novel nanoformulations that are used in the treatment of various challenging and prevalent diseases. It is an exhaustive compilation of the multi-faceted arena of nanoformulations and the healthcare system that caters to the needs of academicians, scholars, researchers etc. The most important aspect of the book covers various types of nanoformulations and their applications in treatment of communicable and non-communicable diseases. Each chapter focuses on a particular nanoformulation as well as a disease including the pathophysiology of the disease, the current treatment modalities of diseases, the role of nanoformulation in treatment and other future aspects and directions for further work. Coverage includes neuropathic pain, colon targeting, nose-to-brain drug delivery, skin cancer, arthritis and tuberculosis.

The disorders induced by iodine deficiency affect at least one billion people. Because ofits effects on brain development, iodinedeficiency is the single most preventable cause of mental retardation in the world. Therefore, the United Nations and the Heads of State of almost all the world's countries represented at the Summit for Children in 1990 adopted resolutions to eradicate the disorders induced by iodine deficiency (IDD) by the year 2000. For geological and socio-economic reasons, most of the populations affected by iodine deficiency disorders live in isolated and usually mountainous areas, in pre industrialized parts ofthe world. The problem of iodine deficiency in Europe has been greatly underestimated in the last decades. After the remarkable studies on the effects of iodine deficiency and their prevention and correction in Switzerland, IDD was generally considered no longer a significant public health problem in Europe. However, surveys carried out in the early 1980's under the auspices of the European Thyroid Association, clearly demonstrated the persistence of moderately or even severely affected areas. These surveys also highlighted the lack ofinformation about large parts ofEurope, especially its eastern part. It is only quite recently, following major changes in international relations and thanks to the support of UNICEF, WHO, the International Council for the Control of Iodine Deficiency Disorders and the European Thyroid Association, that more extensive surveys have been conducted in several parts of Europe hitherto almost unexplored. These surveys showed that most European countries were iodine deficient."

Respiratory function is a major determinant of the overall quality of health and well-being of an individual. This book runs the gamut of chapters devoted to chronic cough-related conditions in children and adults, health care quality and safety, environmental pollution health effects, efficiency of therapeutic approaches and a mutual dependence of respiratory and non-respiratory illnesses. An integrated approach to the investigation and treatment of sleep disordered breathing as well as the use of new and more efficient diagnostic strategies for pleural tuberculosis are presented. Chapters focus on translating science into practice, with an eye on presymptomatic identification of serious ailments for which there could be more effective therapy, leading to improved general health outcomes. This book includes chapters about disorders which will be of interest to clinicians, family practitioners and medical researchers.

This up-to-date reference book compiles the recent developments, innovations, and perspectives on second and third-generation bioplastics. It discusses the main commercialized bioplastics, such as polylactic acid (PLA) and polyhydroxyalkanoates (PHAs). Chapters include the use of alternative raw materials and innovations in bioplastic production processes to reduce costs and decrease environmental impacts. It covers bioplastic production from lignocellulosic biomass, sugars, or oils produced by microbes and municipal waste material. It also includes techno-economic aspects. The book is meant for researchers and industry experts in biotechnology, environmental sciences, and applied microbiology.

William H. Foege, one of the most respected leaders in global public health, takes readers on a tour of his time at the CDC. In its seventy years, the Centers for Disease Control and Prevention (CDC) has evolved from a malaria control program to an institution dedicated to improving health for all people across the world. The Fears of the Rich, The Needs of the Poor is a revealing account of the CDC's development by its former director, public health luminary William H. Foege. Dr. Foege tells the stories of pivotal moments in public health, including the eradication of smallpox (made possible due in part to Foege's research) and the discovery of Legionnaires' disease, Reye syndrome, toxic shock syndrome, and HIV/AIDS. With good humor and optimism, he recounts the various crises he surmounted, from threats of terrorist attacks to contentious congressional hearings and funding cuts. Highlighting the people who made possible some of public health's biggest successes, Foege outlines the work required behind the scenes and describes the occasional tensions between professionals in the field and the politicians in charge of oversight. In recent years, global public health initiatives have come from unanticipated sources. Giants in the field now include President Jimmy Carter and his wife, Rosalynn, who promote programs aimed at neglected diseases. Melinda and Bill Gates have invigorated the field through research and direct program support, especially in the area of vaccine-preventable diseases. And the Merck Mectizan program has dramatically reduced river blindness in Africa. Foege has been involved in all of these efforts, among others, and he brings to this book the knowledge and wisdom derived from a long and accomplished career. The Fears of the Rich, The Needs of the Poor is an inviting but unvarnished account of that career and offers a plethora of lessons for those interested in public health.

This up-to-date reference book discusses the synthesis, production, and application of various microbial enzymes and metabolites for health. Microorganisms like bacteria (lactic acid bacteria, Bacillus species), yeasts, and filamentous fungi have been globally exploited for their biotechnological applications. This book discusses ways to use them commercially. Chapters include the production of fibrinolytic enzymes, microbial lipases, bacteriocin production by lactic acid bacteria, and bioactives produced. It also covers microbial synthesis of alkaloids, terpenoids, and steroids. The book is useful for researchers, academicians, and industry experts in microbiology and biotechnology.

Challenging the concept that since the discovery of the plague bacillus in 1894 the study of the disease was dominated by bacteriology, Ethnographic Plague argues for the role of ethnography as a vital contributor to the configuration of plague at the turn of the nineteenth century. With a focus on research on the Chinese-Russian frontier, where a series of pneumonic plague epidemics shook the Chinese, Russian and Japanese Empires, this book examines how native Mongols and Buryats came to be understood as holding a traditional knowledge of the disease. Exploring the forging and consequences of this alluring theory, this book seeks to understand medical fascination with culture, so as to underline the limitations of the employment of the latter as an explanatory category in the context of infectious disease epidemics, such as the recent SARS and Ebola outbreaks.

Cancer is a leading cause of death among adults. Although about 250f Americans develop cancer in their lifetime, in some populations this rate has been reduced by lifestyle changes. Increasing numbers of people are turning to the use of dietary vegetables, medicinal herbs, and plant extracts to prevent or treat cancer. Their ready availability as "over the counter" supplements has contributed to an explosion in the use of herbal extracts and related compounds for health enhancement.

The spectacular growth of the multi-billion dollar functional food and nutraceutical business, touting health claims sometimes based upon limited research data, underscores the need for this up-to-date reference. "Functional Foods and Nutraceuticals in Cancer Prevention" brings together a leading group of experts on the different aspects of nutrient supplementation, foods, and plant extracts in cancer prevention and treatment. Their conclusions and recommendations present the most current knowledge from which to springboard future research and create a scientific database for accurate health claims.

. This up-to-date resource is a must-have for research professionals, both basic and applied, and marketers in the worldwide functional foods/nutritional supplements industry. It is an essential reference for hospital-based dietitians and nutritionists, physicians specializing in oncology, and cancer researchers. Food and drug officials who determine allowable health claims need this information as well, as do academics in all of these fields

Genomic and Precision Medicine: Foundations, Translation, and Implementation highlights the various points along the continuum from health to disease where genomic information is impacting clinical decision-making and leading to more personalization of health care. The book pinpoints the challenges, barriers, and solutions that have been, or are being, brought forward to enable translation of genome based technologies into health care. A variety of infrastructure (data systems and EMRs), policy (regulatory, reimbursement, privacy), and research (comparative effectiveness research, learning health system approaches) strategies are also discussed. Readers will find this volume to be an invaluable resource for the translational genomics and implementation science that is required to fully realize personalized health care.

Atlas of Mycobacterium Tuberculosis reveals in-depth information about mycobacterium tuberculosis which has never before been reported. Using atomic force microscopy (AFM), the in-depth phenotypic interaction that occurs in different stages of the tuberculosis lifecycle is illustrated, including resting, exponential, and dormant states. Coverage also includes the macroscopic and microscopic anatomy of mycobacterium, including pigmentation, morphology of colonies, size and shape, and the phenotypic changes from susceptible to resistant, all shown with images from electronic and atomic force microscopes. This book will open a new window into the results of molecular changes at the cellular level, guiding researchers and scientists to think in new ways about the area of cell wall and the reproductive and drug resistance phenomena surrounding tuberculosis.