Medical Neurobiology, Second Edition continues the work of Dr. Peggy Mason as one of the few single author textbooks available. Written in an engaging style for the vast majority of medical students who will choose to specialize in internal medicine, orthopedics, oncology, cardiology, emergency medicine, and the like, as well as the student interested in neurology, psychiatry, or ophthalmology, this textbook provides a sturdy scaffold upon which a more detailed specialized knowledge can be built. Unlike other neuroscience textbooks, this new edition continues to focus exclusively on the human, covering everything from neuroanatomy to perception, motor control, homeostasis, and pathophysiology. Dr. Mason uniquely explains how disease and illness affect one's neurobiological functions and how they manifest in a person. Thoroughly updated as a result of student feedback, the topics are strictly honed and logically organized to meet the needs of the time-pressed student studying on-the-go. This textbook allows the reader to effortlessly absorb fundamental information critical to the practice of medicine through the use of memorable stories, metaphors, and clinical cases. Students will gain the tools and confidence to make novel connections between the nervous system and human disease. This is the perfect reference for any medical student, biology student, as well as any clinician looking to expand their knowledge of the human nervous system. New To the Second Edition of Medical Neurobiology: * New sections on cerebral palsy, brain cancer, traumatic brain injury, neurodegenerative diseases, aphasia, and Kallmann syndrome; * Incorporates easy to understand visual guides to brain development, eye movements, pupillary light reflex, pathways involved in Horner's syndrome; * Presents real-life dilemmas faced by clinicians are discussed from both the medical point of view and the patient's perspective; and * Additional reading lists are provided at the end of each chapter that include first-hand accounts of neurological cases and scientific discoveries (e.g. HM). Key Features Include: * Written in an accessible and narrative tone; * Uses metaphors and clinical examples to help the reader absorb the fundamentals of neurobiology; and * Highly illustrated with over 300 figures and tables for full comprehension of topics covered.

This issue of Primary Care: Clinics in Office Practice, Guest Edited by Dr. Mark B. Stephens, is devoted to Cardiovascular Disease. Articles in this issue include: State of the Heart: Overview of disease burden of cardiovascular disease from an epidemiologic perspective; Heavy Heart: Economic burden of heart disease with projections/implications for impact on the health care system; Prevention of Heart Disease; Coronary Artery Disease; Congestive Heart Failure; Valvular Heart Disease; Peripheral Vascular Disease; The Athlete's Heart and Sudden Death; Metabolic Syndrome: systems thinking in heart disease; Women and Heart Disease; Heart Disease in Children; and Cardiac Imaging.

The Management of Lithiasis: The Rational Deployment of Technology addresses the latest developments in the treatment of urolithiasis and biliary stones. The emphasis of the book is on the selection of the cheapest and most effective treatment and is based upon the experience of editors and authors from both the Western countries as well as developing countries in Asia. With health care budgets becoming increasingly restricted, there is a growing interest in cost-controlled and effective treatment methods. This volume covers urinary tract calculi as well as biliary tract calculi, including epidemiology, etiology, choices in the management of calculi, efficacy and safety of treatment and the prevention of urolithiasis.

Rick and Brenda's lives were changed forever when Rick went to the doctor to get a prescription refill. The doctor unexpectedly decided to perform a prostate exam. When he did, he felt a suspicious lump. Weeks later, a biopsy confirmed that Rick had prostate cancer. As a couple, they found their lives changed in unexpected ways following robotic surgery. They decided to share an intimate glimpse into their lives after surgery so other couples would be more prepared than they were. If you are thinking about surgery, or if you just had surgery, you will want to read about their experiences and the life lessons they learned along the way.

Despite what you may have read in the popular press and in social media, Precision Medicine is not devoted to finding unique treatments for individuals, based on analyzing their DNA. To the contrary, the goal of Precision Medicine is to find general treatments that are highly effective for large numbers of individuals who fall into precisely diagnosed groups. We now know that every disease develops over time, through a sequence of defined biological steps, and that these steps may differ among individuals, based on genetic and environmental conditions. We are currently developing rational therapies and preventive measures, based on our precise understanding of the steps leading to the clinical expression of diseases. Precision Medicine and the Reinvention of Human Disease explains the scientific breakthroughs that have changed the way that we understand diseases, and reveals how medical scientists are using this new knowledge to launch a medical revolution.

This book is the one I wish I'd come across when I joined the fraternity or soon thereafter. It takes a hard look at some of the non-medical issues you may not have thought about. If it has succeeded, you'll recognize them when they turn up in your life. You'll learn how some other men have dealt with them and get ideas about how you might manage them in your own way. Not least, you'll discover some new ways to think about your situation.

What this book is not about is treating prostate cancer. There are countless volumes on that topic. It's about dealing and living with prostate cancer; about handling unfamiliar situations that are going to arise; about regaining a sense of control; about living productively, well and yes, happily to the outerlimits of possibilities.

Nicotine and Other Tobacco Compounds in Neurodegenerative and Psychiatric Diseases: Epidemiological Data on Smoking and Preclinical and Clinical Data on Nicotine provides a comprehensive summary of the epidemiological data on smoking and several neurological disorders, including Alzheimer's disease, Parkinson's disease, Multiple Sclerosis, Tourette's syndrome, schizophrenia, anxiety, depression and ADHD, as well as preclinical and clinical data on the effects of nicotine. Despite the obvious and undisputed harmful nature of smoking, evidence suggests that some tobacco and tobacco smoke-derived constituents may offer neuroprotective effects, possibly in combinations, rather than individually. This unprecedented book describes the complex relationships between smoking and neurological disease and the bioactive compounds found in tobacco. It provides a comprehensive review of nicotine and other compounds found in tobacco plant, with scientific evidence of neuroprotective and anti-inflammatory effects that may act in conjunction with nicotine to exert neuroprotective effects observed in smokers. By presenting findings beyond harmful cigarette smoke effects, attention can be drawn to individual compounds of tobacco that may serve as inspiration for further therapy development.

This issue of Medical Clinics, guest edited by Drs. Michael P. Pignone and Kirsten Bibbins-Domingo, is devoted to Disease Prevention. Articles in this issue address prevention for various diseases, including: Breast Cancer; Cervical Cancer; Colorectal Cancer; Lung Cancer; Prostate Cancer; and Screening for Depression. Lipids, CV Risk Assessment, Blood Pressure, and Aspirin for Primary Prevention will also be addressed.

Chronic Medical Disease and Cognitive Aging: Toward a Healthy Body and Brain explores the important and often overlooked connection between how chronic medical diseases of the body can affect cognitive function and brain health. As population demographics shift to that of an aging population it has become more important to understand and improve cognitive function in late life. Chronic medical diseases often increase the risk of cognitive impairment, and those with cognitive impairment may be less able to effectively manage their medical conditions, suggesting a reciprocal relationship may exist where medical disease impacts cognition that in turn may exacerbate physical health. Chronic Medical Disease and Cognitive Aging discusses current research on the association between a variety of chronic medical diseases and cognition and, where appropriate, promising interventions or accepted treatment strategies. While a cure for many diseases continues to be elusive, insights garnered from the interplay between diseases of the body and mind may help point the way to novel therapeutic strategies to improve cognitive function in late life.

This issue of the Cardiac Electrophysiology Clinics, edited by Drs. Amin Al- Ahmad and Francis Marchlinski, will cover Ventricular Tachycardia in Structural Heart Disease. Topics discussed in the issue include, but are not limited to, ECG localization of VT in patients with structural heart disease; Anatomy for VT ablation in structural heart disease; Ablation of VT in ischemic and non-ischemic heart disease; Pace mapping; Ablation of VT in ARVD; Epicardial VT ablation; and VT clinical trials, among others.

Get the tools and knowledge you need for effective diagnosis, evaluation, and management of patients with acute myocardial infarction. Myocardial Infarction: A Companion to Braunwald's Heart Disease, by David A. Morrow, MD, is a comprehensive, hands-on resource that provides practical guidance from a name you trust. Concise and easy to use, this text explores the most recent tools for diagnosis and therapeutic decision-making, as well as the full range of available management strategies, providing outcomes data for each strategy. Myocardial Infarction also includes regular updates with late-breaking clinical trials, reviews of important new articles, and the latest guidance on clinical practice, all selected and masterfully edited by Dr. Eugene Braunwald. Provides thorough discussions of ECG, established and emerging biochemical markers, angiography, nuclear cardiology, echocardiography, and cardiac MRI and CT. Features an extensive treatment section that covers the latest drugs and most recent clinical trials of antiplatelet therapy, coronary revascularization, gene therapy, and approaches to reperfusion injury and ventricular remodeling. Discusses special considerations for the evaluation of acute coronary syndromes in the emergency department, and use of advanced technologies in cardiac critical care. Covers key topics such as in-hospital complications, cardiogenic shock, transitions to post-discharge care, and cardiac rehabilitation. Includes Clinical Practice/Controversy chapters that highlight management-focused, practical topics covering expert approaches for areas of uncertainty. Offers guidance on the management of special populations. Online content includes animations illustrating key pathobiology, including dynamic thrombosis, platelet adherence-activation-aggregation and adverse ventricular remodeling, as well as management strategies and procedural techniques. Regularly updated Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Inner Hygiene explores the serious health threat of constipation, and discusses the extraordinary variety of preventive and curative measures that have been developed to save people from the toxic effects of intestinal irregularity. The book examines the evolution over the last two centuries of the belief that constipation is a disease brought on by an unnatural lifestyle of urban, industrial society. Particular attention is given to the many constipation therapies that people have used, including laxatives, enemas, mineral waters, bran cereals, yogurts, electrotherapy, calisthenics, rectal dilation devices, and many other remedies. The story is carried up to the present and demonstrates that many of constipation therapies of the nineteenth and twentieth centuries are continuing into the twenty-first.

This book describes how epigenetic context, in a large sense, affects gene expression and the development of an organism, using the asymptotic limit theorems of information theory to construct statistical models useful in data analysis. The approach allows deep understanding of how embedding context affects development. We find that epigenetic information sources act as tunable catalysts, directing ontogeny into characteristic pathways, a perspective having important implications for epigenetic epidemiology. In sum, environmental stressors can induce a broad spectrum of developmental dysfunctions, and the book explores a number of pandemic chronic diseases, using U.S. data at different scales and levels of organization. In particular, we find the legacy of slavery has been grossly compounded by accelerating industrial decline and urban decay. Individual chapters are dedicated to obesity and its sequelae, coronary heart disease, cancer, mental disorders, autoimmune dysfunction, Alzheimer's disease, and other conditions. Developmental disorders are driven by environmental factors channeled by historical trajectory and are unlikely to respond to medical interventions at the population level in the face of persistent individual and community stress. Drugs powerful enough to affect deleterious epigenetic programming will likely have side effects leading to shortened lifespan. Addressing chronic conditions and developmental disorders requires significant large-scale changes in public policy and resource allocation.

This volume includes the information necessary to understand recent critical advances in the mechanisms of intestinal tumorigenesis and to comprehend the complexity of the process. The volume aims to entice new researchers to participate in relevant studies, and to provide a forum for discussion within the scientific community to shape future research in this field. Discoveries in intestinal tumorigenesis lead to further understanding of mechanisms involved in colon cancer. Additionally, advancements in techniques and methods open the doors for new approaches to better define the molecular and organismal mechanisms of intestinal tumorigenesis. Chapters are authored by widely published authorities in the field. Each year, there are close to 150,000 new cases of colorectal cancer, which results in approximately 50,000 deaths per year in the United States; these figures render colorectal cancer a significant health concern. Studies attempting to understand the mechanisms of development and progression of colorectal cancer have been ongoing for decades and each year brings new discoveries yielding a better comprehension of the underlying processes at work.

The conquest of scurvy by James Cook during his three famous circumnavigations of 1768-1780 was a product of Cook's character, of his leadership, and of the wisdom of the naturalists who accompanied Cook; specialists who helped locate antiscorbutic plants during stopovers. In this book, Dr. Cuppage shows the importance of careful observation, and of controlled clinical trials. This is an account of the lasting medical effects of Cook's voyages as he tried to liberate mankind from the scourge of scurvy. Cuppage captures the sense of adventure that explorers and scientists share.

This new volume of Current Topics in Developmental Biology provides a comprehensive set of reviews on bHLH transcription factors. bHLH factors are vastly recognized for their diverse roles in developmental processes and their dysfunction underlies various human pathologies. Each chapter is authoritatively written by a leading expert in the field and discusses every possible aspect of this huge and diverse field.

Mitochondria, the "power plants" of eukaryotic cells, are best known for the generation of adenosine triphosphate (ATP), the universal cellular "energy currency" of the cell, and the synthesis of different essential components. Mitochondrial dysfunction is known to lead to various degenerative disorders, disease, and aging. The Mitochondrion in Aging and Disease works to unravel the processes leading to mitochondrial impairments and of pathways involved in mitochondrial quality control and their impact on health and aging will be addressed.