The Neuronal Ceroid Lipofuscinoses is a lysosomal disease which have recently been confirmed by important genetic studies on the NCL which revealed a diversity of at least 8 gene loci related to this group of diseases. ECA-"NCL" represents a multi-national, multi-disciplinary network of researchers on the NCL which have provided new data on this group of diseases. In this book, clinical features, neuroradiological and electrophysiological data, morphological aspects, genetic data and biochemical results will be provided. This book is written for active researchers on NCL and other lysosomal and neurodegenerative diseases, as well as for those interested in NCL for other reasons, foremost patients (and their parents). Tables, illustrations, and most recent references will accompany the text produced and edited by an editorial board consisting of participants of this ECA-"NCL." At the end of this presentation, future lines of research including therapies - will be outlined and emphasized what will have to be done to arrive at complete elucidation of this group of progressive neurodegenerative disorders.

Challenging the concept that since the discovery of the plague bacillus in 1894 the study of the disease was dominated by bacteriology, Ethnographic Plague argues for the role of ethnography as a vital contributor to the configuration of plague at the turn of the nineteenth century. With a focus on research on the Chinese-Russian frontier, where a series of pneumonic plague epidemics shook the Chinese, Russian and Japanese Empires, this book examines how native Mongols and Buryats came to be understood as holding a traditional knowledge of the disease. Exploring the forging and consequences of this alluring theory, this book seeks to understand medical fascination with culture, so as to underline the limitations of the employment of the latter as an explanatory category in the context of infectious disease epidemics, such as the recent SARS and Ebola outbreaks.

An Irish Times book of the year 2022 A powerful, probing book about PTSD. As a journalist Keane has covered conflict and brutality across the world for more than thirty years, from Rwanda, Sudan, South Africa, Somalia, Iraq, Afghanistan, Ukraine and many more. Driven by an irresistible compulsion to be where the night is darkest, he made a name for reporting with humanity and empathy from places where death and serious injury were not abstractions, and tragedy often just a moment's bad luck away. But all this time he struggled not to be overwhelmed by another story, his acute 'complex post-traumatic stress disorder', a condition arising from exposure to multiple instances of trauma experienced over a long period. This condition has caused him to suffer a number of mental breakdowns and hospitalisations. Despite this, and countless promises to do otherwise, he has gone back to the wars again and again. Why? In this powerful and intensely personal book, Keane interrogates what it is that draws him to the wars, what keeps him there and offers a reckoning of the damage done. PTSD affects people from all walks of life. Trauma can be found in many places, not just war. Keane's book speaks to the struggle of all who are trying to recover from injury, addiction and mental breakdown. It is a survivor's story drawn from lived experience, told with honesty, courage and an open heart.

Chronic pain seldom presents alone. Pain patients frequently have comorbid psychiatric conditions and those suffering from mental illness often experience pain. Nonetheless, pain conditions and psychiatric disorders have customarily been understood and treated as different and separate clinical entities, to the detriment of patients' wellbeing. This book will describe the complex and striking relationships between pain and psychiatric disorders, offering the first comprehensive review of the challenging and neglected intersection between pain medicine and psychiatry. Written by world-renowned experts in the fields of pain and psychiatry, chapters contribute a valuable array of clinical and theoretical perspectives and include illustrative case examples throughout.

This book describes how epigenetic context, in a large sense, affects gene expression and the development of an organism, using the asymptotic limit theorems of information theory to construct statistical models useful in data analysis. The approach allows deep understanding of how embedding context affects development. We find that epigenetic information sources act as tunable catalysts, directing ontogeny into characteristic pathways, a perspective having important implications for epigenetic epidemiology. In sum, environmental stressors can induce a broad spectrum of developmental dysfunctions, and the book explores a number of pandemic chronic diseases, using U.S. data at different scales and levels of organization. In particular, we find the legacy of slavery has been grossly compounded by accelerating industrial decline and urban decay. Individual chapters are dedicated to obesity and its sequelae, coronary heart disease, cancer, mental disorders, autoimmune dysfunction, Alzheimer's disease, and other conditions. Developmental disorders are driven by environmental factors channeled by historical trajectory and are unlikely to respond to medical interventions at the population level in the face of persistent individual and community stress. Drugs powerful enough to affect deleterious epigenetic programming will likely have side effects leading to shortened lifespan. Addressing chronic conditions and developmental disorders requires significant large-scale changes in public policy and resource allocation.

This issue of Medical Clinics of North America, edited by Dr. Irl Hirsch, is devoted to Diabetes Management. Articles in this issue include: Diabetes Classification Update; Internet Diabetes Management: An Effective, Efficient, and Cost Effective Approach; Monitoring Glycemia in Diabetes; Glycemic Targets: What is the Evidence?; Lifestyle Modification in Diabetes; Metformin, Sufonlyureas, Acarbose, Thiazolidnediones, Bromocriptine, and Colesevalam; Incretins; SGLT-2 inhibitors; Insulin therapy in Type 1 Diabetes; Insulin Therapy in Type 2 Diabetes; Non-Glycemic Targets for Patients with Diabetes; Screening and Treatment for the Primary Care Provider of Common Diabetes Complications; and Polycystic Ovarian Syndrome.

This volume includes the information necessary to understand recent critical advances in the mechanisms of intestinal tumorigenesis and to comprehend the complexity of the process. The volume aims to entice new researchers to participate in relevant studies, and to provide a forum for discussion within the scientific community to shape future research in this field. Discoveries in intestinal tumorigenesis lead to further understanding of mechanisms involved in colon cancer. Additionally, advancements in techniques and methods open the doors for new approaches to better define the molecular and organismal mechanisms of intestinal tumorigenesis. Chapters are authored by widely published authorities in the field. Each year, there are close to 150,000 new cases of colorectal cancer, which results in approximately 50,000 deaths per year in the United States; these figures render colorectal cancer a significant health concern. Studies attempting to understand the mechanisms of development and progression of colorectal cancer have been ongoing for decades and each year brings new discoveries yielding a better comprehension of the underlying processes at work.

This new volume of Current Topics in Developmental Biology provides a comprehensive set of reviews on bHLH transcription factors. bHLH factors are vastly recognized for their diverse roles in developmental processes and their dysfunction underlies various human pathologies. Each chapter is authoritatively written by a leading expert in the field and discusses every possible aspect of this huge and diverse field.

Mitochondria, the "power plants" of eukaryotic cells, are best known for the generation of adenosine triphosphate (ATP), the universal cellular "energy currency" of the cell, and the synthesis of different essential components. Mitochondrial dysfunction is known to lead to various degenerative disorders, disease, and aging. The Mitochondrion in Aging and Disease works to unravel the processes leading to mitochondrial impairments and of pathways involved in mitochondrial quality control and their impact on health and aging will be addressed.

The conquest of scurvy by James Cook during his three famous circumnavigations of 1768-1780 was a product of Cook's character, of his leadership, and of the wisdom of the naturalists who accompanied Cook; specialists who helped locate antiscorbutic plants during stopovers. In this book, Dr. Cuppage shows the importance of careful observation, and of controlled clinical trials. This is an account of the lasting medical effects of Cook's voyages as he tried to liberate mankind from the scourge of scurvy. Cuppage captures the sense of adventure that explorers and scientists share.

The purpose in writing this book was to fill a void that I noticed in the texts that I was able to read authored by others. I have a unique experience and point of view of musculoskeletal pain honed over 36 years and 45,000 patients. The experience of treating patients directly has been outstanding for me in a professional and personal sense. The advice given in this text is similar to what you would have heard if I had treated you directly. Of course, I have to disclaim any direct results to you if you read this text, because I have not examined you. The ideas are sound, and proven over those many years and great number of patients. The outcome studies verify the validity of the approaches to pain that are written in this text. The approaches we use are scientific, in that the results are predictable, which is the hallmark of science. The examples given as part of the discussion in the text are from my records. This book will empower you to make decisions about your pain.

"Rare Diseases and Orphan Drugs" shows that much of what we now know about common diseases has been achieved by studying rare diseases. It proposes that future advances in the prevention, diagnosis, and treatment of common diseases will come as a consequence of our accelerating progress in the field of rare diseases.

Understanding the complex steps in the development of common diseases, such as cancer, cardiovascular disease, and metabolic diseases, has proven a difficult problem. Rare diseases, however, are often caused by aberrations of a single gene. In rare diseases, we may study how specific genetic defects can trigger a series of events that lead to the expression of a particular disease. Often, the disease process manifested in a certain rare disease is strikingly similar to the disease process observed in a common disease.

This work ties the lessons learned about rare diseases to our understanding of common ones. Chapters covering the number of common diseases are minimized, while rare diseases are introduced as single diseases or as members of diseases classes. After reading this book, readers will appreciate how further research into the rare diseases may lead to new methods for preventing, diagnosing, and treating all diseases, rare or common.
Makes rare diseases relevant to clinicians and researchers by tying lessons learned about the rare diseases to our understanding of the common diseasesStresses basic pathologic mechanisms that account for human disease (e.g., disorders of cell development, replication, maintenance, function and structure), that can be understood without prior training in pathologyDiscusses advanced concepts in molecular biology and genetics in a simple, functional context appropriate for medical trainees and new researchersOffers insights into how further research into rare diseases may lead to new methods for preventing, diagnosing, and treating all diseases.

With the development of advanced screening procedures and techniques, certain limitations of the existing screening processes for disease methodologies and paradigms have been noted. More accurate and less invasive screening methods are needed to diagnose and treat health disorders and diseases before symptoms appear. Pre-Screening Systems for Early Disease Prediction, Detection, and Prevention is a pivotal reference source that utilizes advanced ICT techniques to solve problems in health data collection, analysis, and interpretation, as well as improve existing health systems for the advanced screening of diseases. Using non-invasive biomedical sensor devices and internet of things technology, this book examines safer methods to accelerate disease detection and effectively treat patients while challenging previously used pre-screening processes. While highlighting topics such as the applications of machine learning, patient safety, diagnostics models, and condition management, this publication is ideally designed for healthcare specialists, researchers in health informatics, industry practitioners, and academics.

1. Non-Ulcer Dyspepsia.- 2. Cellular Mechanisms: The Potential Role of Polyamines in Intestinal Adaptation.- 3. From Both Sides Now: The Modulation of Enterocyte Function by Contraluminal and Luminal Factors.- 4. Intestinal Microcirculation: Implications for the Pathogenesis of Gastrointestinal Disease.- 5. Radiation Effects on Normal Intestinal Tissue.- 6. Newly Recognized Bacteria Associated with Gastrointestinal Illness in Humans: Vero Cytotoxin-Producing Escherichia Coli.- 7. Food-Associated Toxicants.- 8. Central Organization of Gastrointestinal Vagal Reflexes.- 9. New Insights into the Pathogenesis and Pathophysiology of Irritable Bowel Syndrome.- 10. Management of the Irritable Bowel.- 11. Cholesterol Gallstones: Recent Advances with Particular Reference to Diet and the Relevance of Changing the Bile Acids of Animal Models.- 12. Diagnosis of Chronic Pancreatic Disease.- 13. Copper Metabolism and Wilson's Disease: An "Ion" Recent Advances.- 14. New Therapeutic Strategies for Chronic Hepatitis..- 15. Therapies for PBC.- 16. Gastrointestinal and Hepatobiliary Complications of Cystic Fibrosis.- 17. Sex Hormones and the Liver.

This issue is the first of a two-part series on Life-Threatening Infections, edited by Dr. Anand Kumar. Article topics include: Meningitis and other non-viral CNS infections, Encephalitis and viral meningitis, Community Acquired Pneumonia, Hospital Acquired Pneumonia/Ventilator Associated Pneumonia, Clostridial gangrene and bacterial myositis, Acute peritonitis and bowel perforations, Post-operative wound and surgical site infections and Fulminant viral hepatitis.

Now in paperback - Chris Wark's bestselling guide can help you beat cancer through a toxin-free diet and lifestyle and embark on your own journey towards wellness and healing. Millions of readers have followed Chris Wark's journey on his blog and podcast, and in Chris Beat Cancer, he dives deep into the reasoning and scientific foundation behind the approach and strategies that he used to successfully heal his body from stage III colon cancer. Drawing from the most up-to-date and rigorous research, as well as his deep faith, Chris provides clear guidance and continuous encouragement for his healing strategies, including his Beat Cancer Mindset; radical diet and lifestyle changes; and means for mental, emotional and spiritual healing. Packed with both intense personal insight and extensive healing solutions, this Wall Street Journal bestseller will inspire and guide you on your own journey.

Global Handbook on Noncommunicable Diseases and Health Promotion David V. McQueen, editor A scan of health challenges around the globe readily brings to mind a range of infectious illnesses, from HIV to influenza. Yet chronic non-contagious conditions--heart disease, asthma, diabetes, cancer--are more prevalent, and their rates soaring, across the developed and developing worlds. The Global Handbook on Noncommunicable Diseases and Health Promotion is an important resource for understanding and approaching chronic illnesses and their prevention. This timely text balances theory and strategies to provide an integrative context for health-affecting behaviors regarding tobacco use, food choices, and physical activity. Coverage expands on current medical/clinical public health perspectives, arguing that closer attention to social context is crucial to better use of health resources and more relevant preventive efforts. Possible roles for hospitals, the workplace, government agencies, NGOs, and other institutions are analyzed, as is the potential for addressing larger underlying health factors (e.g., inequities and poverty) at the societal level. Topics covered include: The nature of causality: beyond traditional evidence Learning from the social sciences in chronic disease health promotion Contextual factors in health and illness Understanding and applying a social determinants of health framework for addressing NCDs Public health, NCDs, health promotion and business partnering NCDs and civil society: a history and a roadmap As the authors of the Global Handbook on Noncommunicable Diseases and Health Promotion make abundantly clear, opportunities are as numerous as the issues, and researchers and graduate students in global public health, health promotion, and chronic disease epidemiology will find these chapters positive and realistic.p>

Por mas de 17 anos, el Dr. Bordenave se ha dedicado a tratar todo tipo de paciente. Durante ese tiempo ha estado expuesto y se a mantenido al frente de multiples avances de tecnologia y de la medicina que ha permitido que la poblacion siga avanzando en edad. Durante estos tiempos tambien se ha visto, un aumento enorme en enfermedades basado en la obesidad, la dieta y nuestro estilo de vida sedentaria. Enfermedades como la diabetes, el cancer, enfermedades cardiovasculares y muchos otros que pueden ser afectado por nuestra nutricion. Durante el transcurso de estos anos, el Dr. Bordenave a tratado y sigue viendo personas de variada y amplia gama socio-economico. Desde figuras importantes de la politica Latino-Americano, a pacientes de bajo o sin recursos economico, a estrellas de television, cine y peliculas norte-americana. Desde jovenes de edad a centenarios, jovenes de corazon. Tal vez hasta algun familiar o vecino suyo, ha sido tratado por el Dr. Bordenave. Siendo tercera generacion de medico, reconoce las tradiciones de la medicina, como la de tratar a cada paciente como un ser individual, cada uno requiriendo un cuidado exclusivo para esa persona. La sanacion del individuo que comprende del cuidado del padecimiento de salud actual, a su estado de salud mental y bienestar completo. Sanacion que empieza al escuchar, tocar, comprender y dialogar con el paciente sin apuro. Tradiciones medicas que desgraciadamente se ha perdido en estos tiempos "modernos" de tecnologia y aumento en volumen de pacientes a ser examinados.

Este libro les hara ver la comida de otra manera. Entendera la importancia de los alimentos que estamos comiendo con el desarrollo de muchas enfermedades, y males que padecemos. Les hara pensar y para muchos le hara cambiar costumbres de alimentacion que han llevado por anos. El Dr. Bordenave sera su guia para poder entender maneras que usted puede tomar para mejorar la salud propia y la de su familia e hijos.

This book contributes to better understand how lifestyle modulations can effectively halt the emergence and progression of human diseases. The book will allow the reader to gain a better understanding of the mechanisms by which the environment interferes with the bio-molecular regulatory processes underlying the emergence and progression of complex diseases, such as cancer. Focusing on key and early cellular bio-molecular events giving rise to the emergence of degenerative chronic disease, it builds on previous experience on the development of multi-cellular organisms, to propose a mathematical and computer based framework that allows the reader to analyze the complex interplay between bio-molecular processes and the (micro)-environment from an integrative, mechanistic, quantitative and dynamical perspective. Taking the wealth of empirical evidence that exists it will show how to build and analyze models of core regulatory networks involved in the emergence and progression of chronic degenerative diseases, using a bottom-up approach.