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Books > Medicine > Clinical & internal medicine > Diseases & disorders > General
In this book, the discussion of the normal and pathological aspects of anxiety is critically examined. A chapter on the molecular basis of anxiety is included, outlining the potential of such approach in the discovery of novel effective pharmacological interventions. The face validity, predictability and usefulness of animal models in the design of valid new efficacious products are discussed. Separate chapters dedicated to each particular type of anxiety such as generalized anxiety disorder, social phobia, posttraumatic stress disorder, panic and obsessive-compulive disorder are included. This book should be of benefit to psychiatrists, clinical psychologists, general practitioners, nurses, students and all those engaged in neuropsychiatric research.
Since the cloning of the cystic fibrosis transmembrane conductance re- lator (CFTR) nearly a decade ago, cystic fibrosis (CF) research has witnessed a dramatic expansion into new scientific areas. Basic researchers, clinicians, and patients increasingly rely on fundamental techniques of genetics, molecular biology, electrophysiology, biochemistry, cell biology, microbiology, and immunology to understand the molecular basis of this complex disease. Research into the pathophysiology of CF has established numerous paradigms of ion channel dysfunction that extend from inflammation and infection in the airways of patients to basic mechanisms of protein processing and regulation in intracellular components. With these rapid advances has come an increasing need for research scientists to understand and utilize a growing array of basic laboratory tools. This volume of Methods in Molecular Medicine, Cystic Fibrosis Methods and Protocols satisfies that need by providing detailed protocols for the laboratory techniques used throughout CF research. From electrophysiology and cell biology, to animal models and gene therapy, the comprehensive set of methods covered here provide step-by-step instructions needed for investigators to incorporate new approaches into their research programs. Contributions have been chosen to reflect the rich diversity of techniques and to provide a cohesive framework for understanding challenges that are currently at the forefront of CF research. It is hoped that this volume will serve as a valuable reference that will not only foster interdisciplinary investigations into current problems encountered in CF, but also facilitate the translation of new scientific discoveries into clinical solutions.
Rising occurrences of various diseases and epidemics have pressurized the already-burdened health system across the globe, and this imposes an unprecedented challenge on our current research in identifying disease-specific biomarkers and molecular targets, in particular for cancers, neurological disorders and unexplained infertility. Despite decades of efforts in deciphering the fundamental biology underlying various diseases at discrete levels using an array of advanced technologies, attempts to identify reliable and disease-indicating markers for detection and biomolecules or cellular structures for targeting are still in vain. This monograph describes and discusses the updated findings in this field with a specific aim to compile prior and recent literature and from there to acquire some insights to facilitate future research to expand options of understanding, detecting and treating diseases. Among the many possible areas of biomedical research, this content comprises two themes: disease biomarkers and molecular targets. The book also covers topics that are more advanced in development to emerging scientific discoveries. In particular, this monograph includesconcepts on the renovated use of oncofetal molecules in cancer prediction and treatment, the evolving development in cancer biology at the cellular and molecular levels and the recent involvement on new classes of molecules in diseases.Thisbook renews established concepts in the field, and at the same time leads to important insights for research and development of drugs, diagnostics, and interventions for managing diseases of unmet medical needs.
This book, the proceedings of Falk Symposium 133 on Mechanisms of Intestinal Inflammation: Implications for Therapeutic Intervention in IBD', held in Berlin, Germany, on 10-11 June 2003, summarizes present knowledge in the area of unspecific and specific immune reactions in the gut, recording the gaps in our knowledge and, in particular, presenting the possibilities of targeted intervention. The link to inflammatory bowel diseases - Crohn's disease and ulcerative colitis - is always in focus. Chapters by an international panel of basic scientists, clinical researchers and clinicians also record the problems which can originate through today's possible modulation of the immune reaction, setting the basis for review of clinical problems. This book is valuable readings for all scientists and physicians, who, from different perspectives, have an interest in research on IBD and in the clinical management of these diseases.
No one expected this journey. Jessica Carmel was born with a severe congenital heart condition. At four days old, her parents learned she would need heart surgery. They had no idea that her future held multiple surgeries and even more unexpected challenges. Fast-forward sixteen years. As Jessica sat in her cardiologist's office for a routine checkup, he told her and her mom that there was nothing more he could do for her. Jessica needed a heart transplant. Three weeks later, Jessica underwent heart transplant surgery. Her recovery was long, but good. Feeling healthier than ever, she went on to graduate high school and college. Soon after her college graduation,however, she began to feel "off." She visited the emergency room for what she thought was severe stomach pain, but it turned out her heart was the real issue. She was admitted to the hospital to relieve fluid, and a couple of days into her stay, a transplant nephrologist informed her she was going to need a kidney transplant. Nearly ten years had passed since Jessica had received her heart transplant, and now she was in desperate need for a kidney. Her only hope to survive was her hero and sister, Amy. Amy came through-right away, she agreed to offer up one of her kidneys. Now, it wasn't enough that Jessica's mom was going to see one daughter off to the operating room, as she had done with Jessica many times before. She would be seeing both her daughters heading into surgery. In The Hearts of a Girl, Jessica shares that story and the story of her many years of struggle to survive and thrive after a long history of challenging surgeries. It's a story that informs and inspires.
Every cell and organism faces the problem of spaces, made up of the two leaflets of the lipid generating a confined space in which metabolic bilayer. The importance of traffic and signaling across membranes is reflected by the estimate and anabolic reactions take place and at the same time allowing entry and exit of metabo that 20% of all genes in the human genome encode membrane proteins. A failure of any of lites, ions, proteins, and signals across its bor der. Evolution has solved the problem by these proteins may have dramatic con se generating lipid membranes that contain trans quences for ceH function. In recent years much porters, ion channels, and receptors. In eukary attention has been paid to diseases resulting otic cells, this problem is exacerbated by the from nonfunctional ion channels ("chan presence of multiple organelles, which are con nelopathies"). Not surprisingly, many of these fined spaces in their own right. Even the lipid diseases affect the excitability of cells. membrane consists of two relatively separate Transporter diseases (perhaps coined "carrier vi PREFACE diseases") are more related to metabolic dis Each chapter is concluded by a summary, and eases, Transporters are frequently found at the most chapters also contain an overview of the beginning or the end of metabolic pathways clinical features of a particular transporter and as a result can have similar effects to disease. a missing enzyme."
"Paindemic is a brutally honest portrayal of our current sick care medical model. No other book gives you such an in-depth and thought-provoking overview of how pain should be assessed and treated. Dr. Cady has truly outdone herself!"-Jamie L. Guyden, MD, Integrative Medicine Physician Are you suffering from chronic pain? Do you feel that everyone, including your physician, thinks you are crazy? Are your loved ones and friends tired of hearing you complain? Are you becoming more depressed and anxious because of your pain? Do you find that you are isolating yourself from others? Are you sick of taking pain medications? Do you question whether injections or surgery are right for you? Is the medical system frustrating you or letting you down? Are you searching for a better way to address your pain? Answering yes to any of these questions means you are part of the very serious pain epidemic in our society. You are not alone! Millions are suffering. The United States is the most advanced society in the world; yet, the majority of pain medications, procedures, and surgeries are not solving this Paindemic. Paindemic will open your eyes to what you should know. Too many unnecessary and risky interventions are being done with little benefit and at great expense. It's time to gain a better perspective to guide you down a more rational path to address and improve chronic pain, even low back pain. Ignorance is not bliss. What you don't know about your pain could hurt you.
Until recently few suffers of cystic fibrosis have survived past
childhood: now they have hope for their future. In the face of major developments, this book brings together
leading research material to provide a concise, informative, and
up-to-date text. With contributions from renowned specialists
worldwide, it explains the new major findings on genetic origins of
the disease together with implementation of treatment. Particular
emphasis is placed on tropical, ethical, and psychosocial
issues. Contents include: This is an invaluable text for respiratory and primary physicians, paediatricians, and all medical professionals seeking knowledge of this dynamic subject.
Discover why millions rely on the #1 New York Times best-selling
Medical Medium for health answers and natural healing protocols they
can’t find anywhere else to over 100 symptoms, nervous system diseases,
and disorders.
Only recently have we begun to appreciate the role of microbiome in health and disease. Environmental factors and change of life style including diet significantly shape human microbiome that in turn appears to modify gut barrier function affecting nutrient & electrolyte absorption and inflammation. Approaches that can reverse the gut dysbiosis represent as reasonable and novel strategies for restoring the balance between host and microbes. In the book, we offer summary and discussion on the advances in understanding of pathophysiological mechanisms of microbial host interactions in human diseases. We will not only discuss intestinal bacterial community, but also viruses, fungi and oral microbiome. Microbiome studies will facilitate diagnosis, functional studies, drug development and personalized medicine. Thus, this book will further highlight the microbiome in the context of health and disease, focusing on mechanistic concepts that underlie the complex relationships between host and microbes.
Magnetic resonance cholangiopancreatography (MRCP) is a novel non-invasive technique for diagnosis of pancreatic-biliary disease. The purpose of this book is to highlight the advantages, limitations and indications of MRCP. Specific examples have been selected to showcase the utility of this technique in a large variety of clinical conditions. Each example is purposefully used to stress important technical features, to give practical advice, or to discuss the role of MRCP in specific clinical situations. Important features of the book are the high quality of the illustrations, the reduction of the text to relevant and practically useful issues, and the simple and logic organisation of the case material. The book should show: the optimal technique in MRCP, the pitfalls and limitations.
In the past five years, so much additional progress has been made in ourunderstanding of both the basic and c1inical aspects of a wide variety of thyroid disorders that a second edition of Diseases of the Thyroid was considered a necessary addition to the Contem porary Endocrinology series. Fresh perspectives also seemed warranted, so we recruited new authors for many of the chapters and believe that this edition will provide the reader with further insights into the pathophysiology and c1inical presentation and treatment of thyroid disease. It inc1udes topics ranging from neonatal thyroid screening, thyroid dysfunction during infancy and childhood, peripartum thyroid disorders, thyroid disease in the elderly, and the c1inical relevance of the sodiurnliodide symporter (NIS) to the pathogenesis and treatment of nodular goiter, thyroid cancer, thyrotoxicosis, and hypothyroidism. The worldwide problem of iodine deficiency and its eradication is also discussed, along with environmental goitrogens and iodine-induced thyroid disease. I am indebted to all the contributors for their cooperation and expertise in providing their chapters in an extremely timely fashion, to Mr. Thomas Moore and Mr. Craig Adams from Humana Press for their expert assistance, and to Ms. Christine Archung for providing superb administrative assistance. Lewis E. Braverman, MD v CONTENTS Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix Molecular Mechanisms of Nuclear Thyroid Hormone Action William W. Chin and Paul M. Yen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2 Nongenomic Actions of Thyroid Hormone Paul 1. Davis and F aith B. Davis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 3 Thyroid Testing: A Clinical Approach Laurie A. Kane and Hossein Gharib . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ."
Disease is an ever-present threat faced by all human societies. Today, this concept has become an influential area of study known as the global burden of disease, which encompasses contemporary health concerns such as the economic costs of disease, the societal impact of illness in developing nations, and infectious diseases resulting from lifestyle exposures. Before we can ease this global burden, it is essential to establish an accurate view of the current status of human health and disease around the world. Addressing key areas that reflect our understanding of disease, The Changing Face of Disease: Implications for Society explores the evolution of disease, the implications for human societies, its ecology, and the current human response. This volume aims to broaden our view of disease at the dawn of the 21st century through topics such as epidemiological transition, mathematical modeling of disease evolution, parasitic disease, urban pollution and illness, and under-nutrition and obesity. Contributions to the text reflect the authors' diverse perspectives and studies on human population biology, biological anthropology, and biomedical and public health issues. This authoritative volume traces the evolution of modern disease and explores contemporary health challenges resulting from genetic, environmental, economic, and lifestyle factors. Through many levels of analysis, it provides a clear picture of the present state of health and disease and reminds us of the global burdens that have yet to be remedied.
The Japanese Ministry of Health, Labor and Welfare, officially recognizing that various risk factors for disease are present in our environment, has proposed the concept of lifestyle-related diseases. These include those diseases that are tied to such lifestyle choices as excessive alcohol consumption, cigarette smoking, exposure to stress, and poor diet. Ongoing attention to this issue led to an International Symposium on Free Radicals and Health: Molecular Interventions and Protection of Lifestyle-Related Diseases bringing together the top experts in that area. With the belief that the recognition of the occurrence of risk factors and their identification are important to overcoming lifestyle-related diseases, three of those experts invited prominent participants at the symposium to contribute to a book. Molecular Interventions in Lifestyle-Related Diseases is the result of that effort. This book is divided into three main sections: Free Radicals, Lifestyle-Related Diseases, and Their Protection Free Radicals, Brain Diseases, and Their Protection Nutraceuticals, Functional Foods, Micronutrients, and Pharmacological Interventions When bad lifestyle choices cause oxidants and free radicals to have a negative influence on cell signaling and gene expression, lifestyle-related diseases are set into motion, which in turn lead to further oxidative stress. Molecular Interventions in Lifestyle-Related Diseases addresses the molecular basis of free radicals and lifestyle-related diseases and preventive/therapeutic approaches including the use of nutraceuticals, functional foods, and pharmacological interventions. Each section contains several chapters addressing critical molecular mechanisms, therapeutic interventions, and other issues of relevance to human health that will be of interest to students and researchers in the health professions including nutritional and environmental scientists, molecular and cell biologi
The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this book, the environmental factors are reviewed, including infectious agents, vaccines as triggers of autoimmunity, smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases. An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), is also included, along with other diseases that are now recognized as having an autoimmune etiopathogenesis.
Current thinking holds that obesity derives primarily from overnutrition (though compelling arguments for other mechanisms, like endocrine disruption by environmental pollutants, also gain support from the literature). In animals, overnutrition is initially handled by adipose tissue expansion; however, exhaustion of this route of lipid sequestering results in oversupply of lipid to other tissues including skeletal muscle, heart, liver, and others. Failure of these tissues to clear excess lipids through either metabolism or sequestration into putatively inert triacylglycerols results in perturbation of bioactive lipid metabolism in cells. In particular, aberrant generation of bioactive sphingolipids is implicated in a multitude of pathological outcomes of metabolic disease including insulin resistance, inflammation, cardiomyopathy, and others. This volume addresses not only the fundamentals of sphingolipid metabolism and analysis, but also the roles of sphingolipids in these disease processes.
Helicobacter pylori Protocols offers an outstanding collection of state-of-the-art protocols for the identification and molecular manipulation of H. pylori. The authoritative contributors supply detailed and readily reproducible protocols for the culturing of H. pylori, for the isolation and restriction endonuclease digestion of H. pylori chromosomal DNA, and for the transformation and insertional mutagenesis of H. pylori. They also provide molecular epidemiological techniques, including ribotyping, PCR-RFLP, and RAPD-PCR. These procedures have been developed by leading practitioners to solve the difficult technical problems created by the application of the powerful bacterial genetic and molecular cloning techniques to H. pylori.
This book documents the primary role of acute hunger (semi- and frank starvation) in the 'fulminant' malaria epidemics that repeatedly afflicted the northwest plains of British India through the first half of colonial rule. Using Punjab vital registration data and regression analysis it also tracks the marked decline in annual malaria mortality after 1908 with the control of famine, despite continuing post-monsoonal malaria transmission across the province. The study establishes a time-series of annual malaria mortality estimates for each of the 23 plains districts of colonial Punjab province between 1868 and 1947 and for the early post-Independence years (1948-60) in (East) Punjab State. It goes on to investigate the political imperatives motivating malaria policy shifts on the part of the British Raj. This work reclaims the role of hunger in Punjab malaria mortality history and, in turn, raises larger epistemic questions regarding the adequacy of modern concepts of nutrition and epidemic causation in historical and demographic analysis. Part of The Social History of Health and Medicine in South Asia series, this book will be useful to scholars and researchers of colonial history, modern history, social medicine, social anthropology and public health.
It is now widely accepted that there are important links between inactivity and lifestyle-related chronic diseases, and that exercise can bring tangible therapeutic benefits to people with long-term chronic conditions. Exercise and Chronic Disease: An Evidence-Based Approach offers the most up-to-date survey currently available of the scientific and clinical evidence underlying the effects of exercise in relation to functional outcomes, disease-specific health-related outcomes and quality of life in patients with chronic disease conditions. Drawing on data from randomized controlled trials and observational evidence, and written by a team of leading international researchers and medical and health practitioners, the book explores the evidence across a wide range of chronic diseases, including:
Each chapter addresses the frequency, intensity, duration and modality of exercise that might be employed as an intervention for each condition and, importantly, assesses the impact of exercise interventions in relation to outcomes that reflect tangible benefits to patients. No other book on this subject places the patient and the evidence directly at the heart of the study, and therefore this book will be essential reading for all exercise scientists, health scientists and medical professionals looking to develop their knowledge and professional practice.
Gain insight on diseases and treatment options for better patient care! Explore human diseases and disorders…from a patient’s perspective! Join the generations of students who have relied on this popular text to introduce them to common human diseases and disorders. Its concise, well-organized approach makes learning about the conditions nearly painless! You’ll better understand your patient’s condition and more easily form a plan of care. And it emphasizes the condition from the perspective of the patient, so you can empathize with the patient as you’re providing care. You’ll want to keep this book long after you’ve finished your program! Access more online. Redeem thecode inside new, printed texts to gain access to a wealth of resources online, including videos, animations, and chapter review podcasts.
Various foods, herbs and spices are used to treat or prevent disease and there have been considerable advances in scientific techniques over the last few decades. These have been used to examine the composition and applications of traditional cures. Modern science has also seen the investigation of herbs, spices and botanicals beyond their traditional usage. Contributions are from leading national and international experts including those from world renowned institutions. Please target oncologists, cancer specialists, physicians, health scientists, healthcare workers, pharmacologists, and research scientists. The audience also includes federal and state program directors. It is valuable to academic libraries that cover the domains of health and medical sciences. It is also suitable for undergraduates, postgraduates, lecturers, and academic professors.
Whilst the body has recently assumed greater sociological significance, there has been less engagement in social work and social care on the bodily experience of health, illness and disease. This innovative volume redresses the balance by exploring chronic illness and social work, through the specific lens of autoimmunity, engaging in wider debates around vulnerability, resistance and the lived experience of ongoing ill-health. Moving beyond existing conceptualisations of vulnerability as an issue of mental distress, ageing, child protection and poverty, Price and Walker demonstrate the role that society has to play in actively engaging the physical body, rather than working around and through it. The book focuses on auto-immune conditions such as lupus, multiple sclerosis, rheumatoid arthritis and scleroderma. Conditions like these allow for an exploration of the materiality of illness which exacerbates social and economic vulnerability and may precipitate personal and social crises, requiring a variety of interventions and support. The risks and challenges associated with chronic illness include disruptions to a sense of self and identity, altered relationships and the renegotiation of roles and responsibilities in a variety of relationships in addition to an economic impact, with the potential for disruption to employment status and financial insecurity. This text opens up a range of debates around some of the central concerns of the social work profession, including vulnerability, ill-health, and independence. It will be of interest to scholars and students of social work, nursing, disability studies, medicine and the social sciences.
LA WRENCE G. RAISZ, MD Division of Endocrinology and Metabolism, University of Connecticut Health Center. Farmington. CT The rapid transfer of new knowledge concerning the pathogenesis, diagnosis, preven tion, and treatment of disease into clinical practice has always been a major challenge in medicine. This challenge is particularly difficult to meet in osteoporosis, not only because has been so much new knowledge generated in recent years, but also because this there disorder has not caught the attention of many practicing physicians. The goal of this volume is to help primary care physicians develop a better understanding of osteoporosis and a more effective approach to diagnosis, prevention, and treatment. As primary care physicians become more and more responsible for the maintenance of health and the prevention of disease, osteoporosis must become one of their important concerns. The magnitude of the problem of osteoporosis has been widely publicized. Within the next 30 years, the cost of hip fractures alone is expected to exceed $40 billion a year in the United States and will be a major cause ofincreased mortality. In addition, vertebral crush fractures will cripple more and more of our elderly population, both men and women. This enormous toll is not inevitable. Current methods of identifying individuals at risk and applying preventive programs could reduce the incidence offractures by 50% or more. This should be the minimum goal of clinicians."
Reversibility of Chronic Disease and Hypersensitivity, Volume 4: The Environmental Aspects of Chemical Sensitivity is the fourth of an encyclopedic five-volume set describing the basic physiology, chemical sensitivity, diagnosis, and treatment of chronic degenerative disease studied in a 5x less polluted controlled environment. This text focuses on treatment techniques, strategies, protocols, prescriptions, and technologies. Distinguishing itself from previous works on chemical sensitivity, it explains newly understood mechanisms of chronic disease and hypersensitivity, involving core molecular function. The authors discuss new information on ground regulation system, genetics, the autonomic nervous system, and immune and non-immune functions. The book also includes the latest technology and cutting-edge techniques, numerous figures, and supporting research.
Anthocyanins, polyphenolic compounds abundant in certain foods, are responsible for the orange-red to blue-violet hues evident in many fruits, vegetables, cereal grains, and flowers. Interest in these pigments has intensified due to their potential health-promoting properties as dietary antioxidants, as well as their use as natural dyes in a variety of products. Mechanistic studies from in vitro experiments as well as in vivo clinical trials demonstrate wide-ranging efficacy and biological activity of anthocyanins. Anthocyanins in Health and Disease presents the first comprehensive review of modern-day research on the relationship of anthocyanins to human health and disease. Written by an interdisciplinary group of distinguished scientists, this book examines the bioavailability, chemistry, metabolism, and efficacy of anthocyanins, as well as their role in protecting the body from several age- and obesity-related chronic diseases. Chapters cover the absorption, digestion, metabolism, and excretion of anthocyanins; current methodology for the assessment of anthocyanins in the blood, plasma, urine, and tissues; and anthocyanins as potent antioxidants. The book discusses health-related topics such as anthocyanins and protection against disease, including cardiovascular disease, metabolic syndrome, type-2 diabetes, and cancers of the gastrointestinal tract. It also addresses health-promoting effects of anthocyanins, namely, maintenance of normal vision and prevention of ocular pathologies, protective effects against skin aging, and their role in innate immunity and exercise. Covering a wide array of specialized knowledge, this book provides an authoritative source of information on the role of anthocyanins in health and disease, an important step toward advancing research and enhancing communication on these functional ingredients. |
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