Key Points: 1. Discusses the role of microbial enzymes in functional food and nutraceutical production 2. Covers a range of enzymes like proteases, pullulanases, lipases 3. Explores various microbial sourcess and processing techniques 4. Reviews application of enzymes in synthesis of chiral drug intermediates 5. Examines molecular techniques on improving microbial enzymes properties and ability

Noncommunicable Diseases: A Compendium introduces readers to noncommunicable diseases (NCDs) - what they are, their burden, their determinants and how they can be prevented and controlled. Focusing on cardiovascular disease, diabetes, cancer and chronic respiratory disease and their five shared main risk factors (tobacco use, harmful use of alcohol, unhealthy diet, physical inactivity and air pollution) as defined by the United Nations, this book provides a synopsis of one of the world's biggest challenges of the 21st century. NCDs prematurely claim the lives of millions of people across the world every year, with untold suffering to hundreds of millions more, trapping many people in poverty and curtailing economic growth and sustainable development. While resources between and within countries largely differ, the key principles of surveillance, prevention and management apply to all countries, as does the need to focus resources on the most cost-effective and affordable interventions and the need for strong political will, sufficient resources, and sustained and broad partnerships. This compendium consists of 59 short and accessible chapters in six sections: (i) describing and measuring the burden and impact of NCDs; (ii) the burden, epidemiology and priority interventions for individual NCDs; (iii) social determinants and risk factors for NCDs and priority interventions; (iv) global policy; (v) cross-cutting issues; and (vi) stakeholder action. Drawing on the expertise of a large and diverse team of internationally renowned policy and academic experts, the book describes the key epidemiologic features of NCDs and evidence-based interventions in a concise manner that will be useful for policymakers across all parts of society, as well as for public health and clinical practitioners.

It has been around since the first rear-impact automobile accident and it will continue to be a problem as long as humans have large, heavy heads perched on slender, highly mobile cervical spines. The subject is whiplash, and some of the brightest minds on the topic gathered in Banff, Alberta, Canada, for the Eighth International Symposium by the Physical Medicine Research Foundation. Editor Dr. Murray E. Allen, Chairman of the Symposium, has collected the findings in Musculoskeletal Pain Emanating From the Head and Neck: Current Concepts in Diagnosis, Management, and Cost Containment to help physicians, physical therapists, chiropractors, and researchers better understand "the new whiplash," make reliable clinical assessments, and provide more effective treatment.This thorough collection includes bump studies with human volunteers, research into safer automobile seat backs and head restraints, postmortem cervical spine examinations, reviews of the literature, and other investigations from around the world. Readers of Musculoskeletal Pain Emanating From the Head and Neck will learn specifically about: injury mechanisms, threshold for injury, and impact severity long-term outcomes of whiplash injury psychological aspects of chronic pain and disability dizziness, imbalance, and chronic incapacity intervertebral joint injuries and cervical synovial joint injuries the Neck Disability Index manipulation and mobilization therapies temporomandibular disorders/temporomandibular pain and dysfunction syndrome (TMPDS)Musculoskeletal Pain Emanating From the Head and Neck is not simply a collection of studies presenting data and findings--rather, it is a compilation of knowledge that illuminates the challenges of treating whiplash and makes some strong and straightforward recommendations for improvement. The contributors and the editor stress to the reader that in order to provide the best possible care, providers must be alert to the many secondary manifestations of whiplash, test for the perception of dysfunction, and be reassuring whenever possible. They must foster an atmosphere of confidence, encourage very early activation, and help persons maintain the momentum of their lives. Furthermore, Dr. Allen calls for caregivers to stop most (if not all) drug treatments, avoid passive failure-mode treatments, and avoid prolonged medicalization of any form of treatment. By studying the findings and following the recommendations of the international experts contributing to Musculoskeletal Pain Emanating From the Head and Neck, physicians, chiropractors, and physical therapists will foster self-reliance in their patients and improve diagnosis, treatment, and cost containment of whiplash.

The only complete, scientifically rigorous, fully integrated reference giving a wide ranging and in-depth perspective on cerebral palsy and related neurodevelopment disabilities. It considers all aspects of cerebral palsy from the causes to clinical problems and their implications for individuals. Leading scientists present the evidence on the role of pre-term birth, inflammation, hypoxia, endocrinological and other pathways. They explore opportunities for neuroprotection leading to clinical applications. An international team of experts provides clinicians and researchers with key information on the mechanisms underlying impairments in movement, development, cognition, communication, vision, feeding, behaviour, sexuality, and musculoskeletal deformities. They present a wide range of person-centred assessment approaches, including clinical evaluation, measurement scales, neuroimaging and gait analysis. The principles of multi-disciplinary management are presented, in terms of therapist intervention, medication and surgery. The perspective of the book spans the lifelong course of cerebral palsy, taking into account worldwide differences in socio-economic and cultural factors. Many chapters are illustrated with clinical vignettes enabling direct translation into practice. Full integrated colour, with extensive cross-referencing make this a highly attractive and useful reference.

A physician with thirty-five years of experience treating people with brain injuries shares the latest research on concussions and best practices for care. The explosion of attention to sports concussions has many of us thinking about the addled brains of our football and hockey heroes. But concussions happen to everyone, not just elite athletes. Children fall from high chairs, drivers and cyclists get into accidents, and workers encounter unexpected obstacles on the job. Concussions are prevalent, occurring even during everyday activities. In fact, in less time than it takes to read this sentence, three Americans will experience a concussion. The global statistics are no less staggering. Shaken Brain offers expert advice and urgently needed answers. Elizabeth Sandel, MD, is a board-certified physician who has spent more than three decades treating patients with traumatic brain injuries, training clinicians, and conducting research. Here she explains the scientific evidence for what happens to the brain and body after a concussion. And she shares stories from a diverse group of patients, educating readers on prevention, diagnosis, and treatment. Few people understand that what they do in the aftermath of their injury will make a dramatic difference to their future well-being; patient experiences testify to the best practices for concussion sufferers and their caregivers. Dr. Sandel also shows how to evaluate risks before participating in activities and how to use proven safety strategies to mitigate these risks. Today concussions aren't just injuries-they're big news. And, like anything in the news, they're the subject of much misinformation. Shaken Brain is the resource patients and their families, friends, and caregivers need to understand how concussions occur, what to expect from healthcare providers, and what the long-term consequences may be.

This series of pocketbooks sets out to provide easily-assimilable, essential information on the diagnosis and treatment of the most common medical conditions. This volume deals with reflux and oesophageal problems.

A useful and comprehensive resource for anyone who has fallen through the medical cracks, 'Healing Is Possible' provides readers with new hope for healing. Through direct, hands-on experience, Dr. Nathan has brought countless people relief from their long-term symptoms and illnesses. Like a top-notch medical detective, Dr. Nathan gathers the facts and uncovers the clues one by one to bring about a steady improvement in his patients' health.

Informed by an amalgamation of psychoanalytic and attachment theories, the techniques offered in this book can be employed alongside a variety of therapeutic modalities, such as evidenced-based cognitive-behavioral treatment; social learning, family systems, emotion-focused, Ericksonian, and solution-focused approaches; gestalt, psychodynamic, and narrative therapies; as well as play therapy and the therapies of the creative arts. 'Evocative strategies' have been developed for the purpose of engaging children in an emotionally meaningful process. Crenshaw illustrates that in order to create moments of transformation and change in and through the therapy process, we have to learn the language of the heart-where children in their essence live.

Medical Nutrition and Disease: A Case-Based Approach is an ideal way for medical students, physician assistant students, dietetic students, dietetic interns, and medical residents to advance their nutrition knowledge and skills. Dietitians in clinical practice and dietetic educators will also benefit from the updated nutrition concepts and case-based approach. The 5th edition of this best-selling text has been fully updated and includes 13 chapters and 29 cases, with 6 brand new cases. The text is a practical guide to the role that nutrition plays in disease prevention, treatment, and management and also provides 48 self-study continuing education credits (C.E.) for dietitians. Medical Nutrition and Disease: Features learning objectives and current references in every chapter and case Teaches you how to diagnose and manage nutritional problems, integrate nutrition into clinical practice, and answer your patients most common questions Includes nutritional advice for children, teenagers, pregnant women, and older adults Includes contributions from nationally recognized nutritionists and physicians who teach nutrition in medical schools, and undergraduate and dietetic programs Registered dietitians can earn 48 C.E. credits from the Academy of Nutrition and Dietetics by successfully completing the updated multiple-choice questions included in the book. Everything has been pre-approved by the Commission on Dietetic Registration and there are no additional fees.

This volume utilizes various neurological diseases as its organizing principle, focusing specifically on their personal, social, and cognitive consequences. In so doing, it provides neuropsychologists, clinical psychologists, and those in related disciplines with an accessible survey of the available research on the psychological functioning of patients with the various disorders. Each chapter consists of a background review of the major features of one of the diseases, including symptom pattern, neuroanatomical bases, neuropathology, genetic factors, and epidemiology. Finally, the psychological and cognitive deficits established by research are reviewed, and their practical implications are discussed.

First published in 1963, Advances in Parasitology contains comprehensive and up-to-date reviews in all areas of interest in contemporary parasitology. Advances in Parasitology includes medical studies of parasites of major influence, such as Plasmodium falciparum and trypanosomes. The series also contains reviews of more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications. The 2012 impact factor is 3.778.

This book is open access under a CC BY license.
The grand narrative of twentieth-century medicine is the conquering of acute infectious diseases and the rise in chronic, degenerative diseases. The history of fungal infections does not fit this picture; indeed, it runs against it - this book charts the path of fungal infections from the mid nineteenth century to the dawn of the twenty-first century, both in Britain and the United States. It examines how fungal infections became more prevalent and serious over the century, a rise that was linked to the increased incidence of chronic diseases and to social, technological and medical 'progress'. In 1900, conditions such as ringworm, athlete's foot and thrush were minor, external and mostly chronic conditions - irritating, but mostly self-limiting. In the subsequent decades, these infections remained very common, but were better controlled by antifungal drugs. However, by the year 2000 doctors were faced by a growing number of serious and life-threatening fungal infections, such as invasive aspergillosis and systemic candidiasis. These infections principally affect patients who have benefited from medical advances, such as antibiotic treatment and transplantation, and those with immuno-compromised conditions.

Volume 109 of "Current Topics in Developmental Biology" covers mouse models of the nuclear envelopathies and related diseases, with contributions from an international board of authors. The chapters provide a comprehensive set of reviews covering such topics as mouse models neurodegenerative diseases including Parkinson s and dystonia, muscle ageing and sarcopenia, cardiac failure and repair, ageing and prospects lifespan extension, lipodystrophy and the significance in fat regulation, also identifying developmental mutations in mammals and nuclear envelope and LINC complex in disease.
Covers the area of mouse models of developmental genetic diseaseInternational board of authors Provides a comprehensive set of reviews covering such topics as mouse models neurodegenerative diseases including Parkinson s, muscle aging, lipodystrophy, and more"

The author of the bestselling Plant Paradox series takes a fresh look at one of the top health issues plaguing Americans-fatigue-and offers a revolutionary plan for boosting energy and revitalizing mental and physical stamina. In his bestselling books, The Plant Paradox and The Longevity Paradox, Dr. Steven R. Gundry offered game-changing perspectives on our wellbeing. In The Energy Paradox, Dr. Gundry expands upon his previous discussions of gut, microbiome, and mitochondrial health, linking immune malfunction to the mental and physical symptoms of fatigue-including exhaustion, brain fog, depression, anxiety, and low metabolism. As Dr. Gundry explains, feeling tired, moody, and zapped of energy is not normal, no matter your workload or age. Fatigue is an SOS flare from the body, one that is intended to alert us that something is wrong. In his clinical work, Dr. Gundry has found that his patients who complain of feeling sick and tired all the time almost always have something in common: the inflammation markers of a leaky gut. In The Energy Paradox, Dr. Gundry will offer readers the information and tools necessary to quiet the autoimmune battle raging within-a battle that depletes precious energy reserves, leaving you drained and prone to mood disorders and weight gain. With new guidelines on how to increase mitochondrial energy production and nourish the microbiome; 30 new Plant Paradox-approved recipes; and lists of energy-boosting foods to consume and energy-depleting foods to avoid, The Energy Paradox will help readers take back their lives, giving them the energy they need to feel, look, and be their best.

CFS is an elusive, difficult to treat condition. Symptoms include fatigue, muscle and joint pain, felling unwell after exercise, unrefreshing sleep, and memory/concentration problems. This groundbreaking book directly addresses the myriad causes of CFS and offers restorative vitamin and other treatments capable of safely reducing symptoms.

A fascinating exploration of the skin in its multifaceted physical, psychological, and social aspects Providing a cover for our delicate and intricate bodies, the skin is our largest and fastest-growing organ. We see it, touch it, and live in it every day. It is a habitat for a mesmerizingly complex world of micro-organisms and physical functions that are vital to our health and our survival. It is also a waste removal plant, a warning system for underlying disease and a dynamic immune barrier to infection. One of the first things people see about us, skin is crucial to our sense of identity, providing us with social significance and psychological meaning. And yet our skin and the fascinating way it functions is largely unknown to us. In prose as lucid as his research underlying it is rigorous, blending in memorable stories from the past and from his own medical experience, Monty Lyman has written a revelatory book exploring our outer surface that will surprise and enlighten in equal measure. Through the lenses of science, sociology, and history--on topics as diverse as the mechanics and magic of touch (how much goes on in the simple act of taking keys out of a pocket and unlocking a door is astounding), the close connection between the skin and the gut, what happens instantly when one gets a paper cut, and how a midnight snack can lead to sunburn--Lyman leads us on a journey across our most underrated and unexplored organ and reveals how our skin is far stranger, more wondrous, and more complex than we have ever imagined.

An accessible, comforting and practical book for anyone experiencing anxiety, from the author of The Recovery Letters and How to Tell Depression to Piss Off. Despite more and more people opening up about their mental health, anxiety is still taboo. We're not supposed to be anxious; we're supposed to be resilient and able to 'get on with it'. We are expected to excel while juggling a hectic, pressurised schedule at home and at work, despite the lines between the two being more blurred than ever. This book dispels that taboo. It is for anyone who has experienced general anxiety disorder, trauma-related anxiety, clinical anxiety and those with 'low-level' anxieties. At once empathetic and entertaining, How to Tell Anxiety to Sod Off offers 40 ways to get to a better place with anxiety. They are born out of the author's personal experience of managing his own anxiety and his many years of working as a counselor helping people with their mental health.

"At last... a book about chronic pain that covers every aspect of this huge issue. A possible solution for nearly everyone who is suffering." -Christiane Northrup, M.D., New York Times-bestselling author Do you have arthritis, back pain, fibromyalgia, or another form of pain? This foundational book on chronic pain offers a holistic guide to living pain-free, which incorporates traditional medicine and natural solutions such as supplements, reflexology, meditation, cannabis, and more. In Rethink Chronic Pain, medical doctor and proven chronic pain expert, Dr. Gaetan Brouillard, identifies the physical and psychological roots of pain and recommends not one single treatment (as the vast majority of pain books do) but many: he combines osteopathy, hypnotherapy, acupuncture, nutrition, mindfulness, and natural products (including cannabis and CBD) into his tried-and-tested approach, which he has used to heal patients in his own practice. Dr. Brouillard also draws on his years of experience as an emergency room doctor, clinician, and medical researcher to explain scientific breakthroughs in pain treatment and how to use traditional medicine and surgery when necessary. Throughout the book, Dr. Brouillard explores all aspects of pain. He explains the connection between pain and depression and anxiety; the biological and environmental causes of pain; the impact of pain on our finances; the importance of sleep for chronic pain recovery; and the relationship between pain and what we eat. Finally, he shares the benefits of meditation and creative thinking for living a pain-free life. An illustrated Pain Guide covers an abundance of different pain types and their treatment options including: Arthritis and osteoarthritis Fibromyalgia Headaches Neck Pain Scoliosis Herniated discs Carpal tunnel syndrome Sciatica Plantar fasciitis And so much more Readers will come away with new understandings of their pain and different treatment options-as well as renewed confidence for healing chronic pain at its source.

This book aims to redefine the requirements of an effective care for the chronic diseases, and their difficulties of implementation; to analyze the processes allowing to reinforce quality and to contain the costs and the expenditure related to this care; and to release the dynamic processes of development of an efficient care, the organisational forms and the corresponding strategies.