This book will identify the top dermatological conditions for patients with skin of color and provide essential features which contrast these conditions in darker skin types. The reader will be able to formulate informed treatment regimens for patients with skin of color. The book will also provide clinical pearls to guide decision making, as well as important cultural beliefs that must be considered in order to provide optimal care to patients with skin of color. Clinical cases are a key component in modern medical education, assisting the trainee or recertifying clinician to work through unusual cases using best practice techniques. Dermatology is an important discipline in this regard since it is a highly visual subject requiring the reader to describe often very subtle differences in the presentation of patients and define accurately the diagnostic and management criteria to base their clinical decision-making on. By the year 2050, people with skin of color (including Africans, African Americans, Asians, Native Americans and Hispanics) will represent more than half of the U.S. population. There is now an increasing demand for dermatologic treatments in patients with skin of color, as well as an accompanying need for education and training in this quickly expanding market. Skin of Color is a key topic within dermatology as specific conditions can be harder to diagnose effectively in darker skin, and their treatment can be compromised by this. Conditions such as psoriasis, eczema, and atopic dermatitis may be more difficult to diagnose in darker skin. There are various other conditions that can provide a challenge in management, including postinflammatory hyperpigmentation, melasma, scarring, alopecias, and pseudofolliculitis barbae. If these skin disorders are not diagnosed and treated properly, the initial lesions can become darker as they heal, and the darker spots can last for years in some cases.

This book contains a series of contributions from internationally renowned academics with special expertise in one or other diseases which collectively are grouped under the heading myeloproliferative disorders. There have been many recent developments in understanding the pathophysiology and a number therapeutic innovations in this area. A feature of this book is the speed with which it has been produced - an important factor in this rapidly moving field.

Phosphoinositides (PIs) are minor components of cellular membranes that play critical regulatory roles in several intracellular functions. This book describes the main enzymes regulating the turnover of each of the seven PIs in mammalian cells, some of their intracellular functions and some evidence of their involvement in human diseases. Due to the complex inter-relation between the distinct PIs and the plethora of functions that they can regulate inside a cell, this book is not meant to be a comprehensive coverage of all aspects of PIs signalling but rather an overview on the current state of the field and where it could go from here. Phosphoinositide and inositol phosphates interact with and modulate the recruitment and activation of key regulatory proteins and in doing so control diverse functions including cell growth and proliferation, apoptosis, cytoskeletal dynamics, insulin action, vesicle trafficking and nuclear function. Initially, inositide signaling was limited to the PLC pathway; however, it is now clear that all the seven phosphoinositides and more than 30 different inositol phosphates likely have specific signaling functions. Moreover there is a growing list of proteins that are regulated by inositol signaling. This has raised the question as to how inositol signaling can control diverse processes and yet maintain signaling specificity. Controlling the levels of inositol signaling molecules and their subcellular compartmentalisation is likely to be critical. This meeting will bring together scientists from different backgrounds to discuss how understanding inositol signaling may be used to target complex human diseases that manifest themselves when inositol signaling is deregulated.

The global outbreak of Covid-19 appears to be unprecedented in a world which has not suffered a serious pandemic for a century, while society had almost forgotten the enormous impact of highly infectious diseases throughout history. Pestilence, however, has played a major role in ending the Golden Age of Athens, wrecking Justinian's plans to restore the Roman Empire to its former glory, and killing untold millions in Latin America after the Spanish invasion. Despite its importance, historians have tended to minimise the role of infectious disease, partly because of a lack of scientific knowledge. This has resulted in a distorted view both of the past and of the danger of disease to modern society. In Armies of Pestilence, R.S. Bray, a distinguished biologist and an able historian, corrects this view with an exploration of the influence of disease on history. The book surveys the principal epidemics around the world and across the centuries, including scholarly discussion around those which cannot be certainly identified. In each case, Bray examines the origins of the outbreaks, as well as the symptoms, the mortality rate and the social and economic turmoil left in their wake. Bray pays special attention to the infamous organism that caused the Black Death, Yersina pestis, as well as other grimly familiar bogey-men of pestilential history including malaria, smallpox, typhus, cholera and influenza, and AIDS. Government responses to outbreaks are assessed, and the inability of governments to deal effectively with disease is a recurring theme. The relationship between disease and war, with the former often responsible for more deaths than the latter, is also considered in detail, as was the case during the last great influenza pandemic of 1918-19, at the end of the First World War

Epilepsy has a fascinating history. To the medical historian Oswei Temkin it was 'the paradigm of the suffering of both body and soul in disease'. It is justifiably considered a window on brain function. And yet its story is more than simply a medical narrative, but one influenced also by scientific, societal and personal themes. Written for a medical and non-medical readership, this book describes the major developments in epilepsy between 1860-2020, a turbulent era in which science dominated as an explanatory model, medical theories and practices steered an erratic course, and societal attitudes and approaches to epilepsy fluctuated dramatically. In the middle of this maelstrom was the person with epilepsy at the mercy of social attitudes and legislation, and at times harmed as well as helped by medicine and science. So entangled is the history that intriguingly, as an entity, epilepsy may now be thought not even to exist.

The two parts of this volume feature seventeen and six extended conference abstracts corresponding to selected talks given by participants at "Joint CRM-Imperial College Workshop in Complex Systems" and "Emergence, Spread and Control of Infectious Diseases" respectively, both held at the Centre de Recerca Matematica in Barcelona in spring 2013. Most of them are short articles giving preliminary presentations of new results not yet published in regular research journals. The articles are the result from a direct collaboration among active researchers in the area after working in a dynamic and productive atmosphere.Almost everything that is interesting and important for society is complex; here, examples scattered across science are presented in order to illustrate the cross-disciplinary richness of state-of-the-art complex systems research: fracture avalanches and rain showers that mimic earthquakes; highly organized graphs that account for processes in neural networks, metabolic networks, food webs, or language; models for DNA dynamics; or statistical methods to test complexity in the form of structure along many different scales. The mathematics is put to work for the modeling of the real system, and the models are kept at a minimum level to allow the understanding of the essentials of the real system. The book is intended for established researchers, as well as for PhD and postdoc students who wish to learn more about the latest advances in these active areas of research."

This comprehensive textbook addresses one of the major public health concerns of our era - obesity. Clearly and simply, "Obesity: science to practice" provides a balanced, coherent account of obesity: how to define and measure it, its epidemiology, the physiological basis, associated diseases, how to assess, manage and treat it, and also strategies for prevention. The book is generously illustrated, including graphs and flow charts for easy reference. The chapters cite key references so that interested readers may pursue a given topic in more detail. Well presented and thoroughly edited by one of the leading experts in the field, this is the textbook of choice for anyone working in obesity.

Rising occurrences of various diseases and epidemics have pressurized the already-burdened health system across the globe, and this imposes an unprecedented challenge on our current research in identifying disease-specific biomarkers and molecular targets, in particular for cancers, neurological disorders and unexplained infertility. Despite decades of efforts in deciphering the fundamental biology underlying various diseases at discrete levels using an array of advanced technologies, attempts to identify reliable and disease-indicating markers for detection and biomolecules or cellular structures for targeting are still in vain. This monograph describes and discusses the updated findings in this field with a specific aim to compile prior and recent literature and from there to acquire some insights to facilitate future research to expand options of understanding, detecting and treating diseases. Among the many possible areas of biomedical research, this content comprises two themes: disease biomarkers and molecular targets. The book also covers topics that are more advanced in development to emerging scientific discoveries. In particular, this monograph includes concepts on the renovated use of oncofetal molecules in cancer prediction and treatment, the evolving development in cancer biology at the cellular and molecular levels and the recent involvement on new classes of molecules in diseases. This book renews established concepts in the field, and at the same time leads to important insights for research and development of drugs, diagnostics, and interventions for managing diseases of unmet medical needs.

Providing essential support to schools and universities that offer yoga therapy training programs, this comprehensive, edited textbook develops robust curricula, enabling them to prepare yoga therapists to integrate into healthcare settings safely and effectively. The book includes a large and international list of contributors from diverse lineages and backgrounds such as Matthew Taylor, Gail Parker and Steffany Moonaz, and is the first resource on yoga therapy that aligns with the educationl competencies of the International Association of Yoga Therapists (IAYT). It covers yoga foundations (philosophical background, ayurveda, tantra), biomedical and psychological foundations, yoga therapy tools and therapeutic skills, yogic and biopsychosocial-spiritual assessments, and professional practices. As the field of yoga therapy continues to root and grow, this book is essential for both new yoga therapy practitioners, and for schools developing training programs.

The overall objective of this book is to provide standards for the knowledge, skills, and attitudes expected of all hospitalists and to provide a framework for ongoing professional and curriculum development for learners at all levels. The framework is intended for use by hospital medicine program directors, directors of medical student clerkships, residency programs, fellowships, and continuing medical education, as well as other educators involved in curriculum development. The competencies do not focus on specific content, but rather general learning objectives within the skills, knowledge, and attitudes related to each topic. Attaining competency in the areas defined in these chapters is expected to require post-residency training. This training is most likely to be obtained through a combination of work experience, local mentorship, and engagement in specific educational programs or fellowship. Hospitalists, directors, and educators can create specific instructional activities and methods chosen to reflect the characteristics of the intended learners and context of the practice environment.

Within each section, individual chapters on focused topics provide competencies in three domains of educational outcomes: the Cognitive Domain (Knowledge), the Psychomotor Domain (Skills), and the Affective Domain (Attitudes). To reflect the emphasis of hospital medicine practice on improving healthcare systems, a fourth section entitled Systems Organization and Improvement is also included. An attempt has been made to make the objectives timeless, allowing for creation of curriculum that can be nimble and reactive to new discoveries.

Although the entire document can be a resource for comprehensive program development, each chapter is intended to stand-alone and thus support curriculum development specific to the needs of individual programs.

This Brief provides a concise review of chaperonopathies, i.e., diseases in which molecular chaperones play an etiologic-pathogenic role. Introductory chapters deal with the chaperoning system and chaperoning teams and networks, HSP-chaperone subpopulations, the locations and functions of chaperones, and chaperone genes in humans. Other chapters present the chaperonopathies in general, including their molecular features and mechanistic classification into by defect, excess, or mistake. Subsequent chapters discuss the chaperonopathies in more detail, focusing on their distinctive characteristics: primary or secondary; quantitative and/or qualitative; structural and hereditary or acquired; genetic polymorphisms; gene dysregulation; age-related; associated with cancer, chronic inflammatory conditions, and autoimmune diseases. The interconnections between the chaperoning and the immune systems in cancer development, chronic inflammation, autoimmunity, and ageing are outlined, which leads to a discussion on the future prospects of chaperonotherapy. The latter may consist of chaperone gene and protein replacement/supplementation in cases of deficiency and of gene or protein blocking when the chaperone actively promotes disease. The last chapter presents the extracellular chaperones and details on how the chaperone Hsp60 is secreted into the extracellular space and, thus, appears in the blood of cancer patients with potential to participate in carcinogenesis and chronic inflammation and autoimmunity. Chaperones as clinically useful biomarkers are mentioned when pertinent. Likewise, guidelines for clinical evaluation of chaperonopathies and for their histopathological and molecular identification are provided throughout. The book also provides extensive bibliography organized by chapter and topic with comments. "

This book contains selected contributions to the 16th European Conference on Psychosomatic Research, held in Athens from September 6 to 11, 1986. The t of psychosomatic medicine was one of the two basic topics of the meeting. We thought that, since this topic has a touch of history in it, it would be appropriate for a conference held in Greece. It is really amazing how advanced the psychosomatic conceptions of the ancient Greek philosophers and physicians were. It was the basic psychosomatic ideology that Socrates was expressing when he taught: "S"lOTT :: P O

Proteases are everywhere from prokaryotes to eukaryotes, from virus to bacteria and in all human tissues, playing a role in many biological functions. Among these functions, the inflammatory reaction is of particular interest. In inflamed tissues, proteases can have a microbial and/or host origin and are involved not only in tissue remodeling, but also in specific signaling to resident or inflammatory cells, thereby contributing to the innate immune response.

This volume presents all advances in our knowledge of the role proteases and their inhibitors play in various diseases associated with inflammatory response. Mechanisms involved in protease signaling to cells are presented, and the different types of proteases that are present at inflammatory sites and their effects on the course of inflammation are discussed. Finally, the evidence for considering proteases and their receptors as potential molecular targets for therapeutic interventions in the treatment of inflammatory diseases is discussed in the context of specific organ inflammatory pathologies (the lung, gastrointestinal tract, skin, joints, etc.).

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The book will provide an overview of the roles of vascular adhesion molecules in health and disease, with chapters on their cell biology, followed by chapters reviewing their importance in specific disease processes. Vascular adhesion molecules are vital for the physiological processes of leukocyte trafficking and also critically involved in the enhanced leukocyte emigration that is a key feature of all inflammatory and immune diseases. The book is designed to provide up-to-date, linked reviews of the subject suitable for postgraduate students entering the field or research workers from allied disciplines needing a modern overview.

Literally thousands of papers have been published on nitric oxide over the past ten years. But there is no single monograph available that has previously attempted to summarize the important features of the roles of nitric oxide in inflammation. The voluminous literature regarding the incredible range of chemical and biological effects of nitric oxide and reactive nitrogen oxide species, RNOS, may present a tangle of confusing information to the researcher. This volume brings together experts from nitric oxide and inflammation research and presents a concise up-to-date overview as well as future aspects of this rapidly growing field.

Thousands of people from more than eighty countries have traveled to China since 2001 to undergo fetal cell transplantation. Galvanized by the potential of stem and fetal cells to regenerate damaged neurons and restore lost bodily functions, people grappling with paralysis and neurodegenerative disorders have ignored the warnings of doctors and scientists back home in order to stake their futures on a Chinese experiment. Biomedical Odysseys looks at why and how these individuals have entrusted their lives to Chinese neurosurgeons operating on the forefront of experimental medicine, in a world where technologies and risks move faster than laws can keep pace. Priscilla Song shows how cutting-edge medicine is not just about the latest advances in biomedical science but also encompasses transformations in online patient activism, surgical intervention, and borderline experiments in health care bureaucracy. Bringing together a decade of ethnographic research in hospital wards, laboratories, and online patient discussion forums, Song opens up important theoretical and methodological horizons in the anthropology of science, technology, and medicine. She illuminates how poignant journeys in search of fetal cell cures become tangled in complex webs of digital mediation, the entrepreneurial logics of postsocialist medicine, and fraught debates about the ethics of clinical experimentation. Using innovative methods to track the border-crossing quests of Chinese clinicians and their patients from around the world, Biomedical Odysseys is the first book to map the transnational life of fetal cell therapies.

This volume contains contributions by well-known scientists and clinicians in the fields of microbiology, infectious diseases, physiology, internal medicine, surgery, anaesthesiology, and intensive care medicine. It provides an up-to-date overview of the mediators and pathophysology of sepsis and septic shock as well as the latest therapeutic approaches.

JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.

Jaundice ofnewbom infants was described by several authors in the 17th century. The condition, however, was usually thought of as being similar to adult jaundice and due ro occlusion of the bile ducts by 'glutinous humours'. On the other hand, some writers reported on the fact that more than one consecutive baby was often affected, and there is a classic example of the disease in twins written by Louyse Bourgeois, the midwife of Marie de Medici, in 1609. It was not until early in the 20th century that it was realised that the common link between these familial cases was anaemia, and later still that this was of the haemolytic type. The breakthrough, in terms of an idea, came in 1938, when Darrow postulated that the baby's red cells were destroyed by an immune reaction on the part of the mother, the result of immunisation by paternal factors in the fetus. Shortly afterwards Wiener discovered an entirely new blood group system, 'Rh', and it was found that it was in compatibility within this system that was responsible for the vast majority of cases of haemolytic disease of the newborn."

This book discusses how human beings cope with serious physical ill ness and injury. A conceptual model for understanding the process of coping with the crisis of illness is provided, and basic adaptive tasks and types of coping skills are identified. The major portion of the book is organized around various types of physical illness. These physical illnesses, which almost all people face either in themselves or their family members, raise common relevant coping issues. The last few sections cover "the crisis of treatment," emphasizing the importance of unusual hospital environments and radical new medical treatments, of stresses on professional staff, and of issues related to death and the fear of dying. The material highlights the fact that people can successfully cope with life crises such as major ill ness and inj ury, rather than the fact that severe symptoms and/or breakdowns sometimes occur. The importance of support from professional care-givers, such as physicians, nurses, and social workers, and from family, friends, and other sources of help in the community, is emphasized. Many of the selections include case examples which serve to illustrate the material. Coping with Physical Illness has been broadly conceived to meet the needs of a diverse audience. There is substantial information about how human beings cope with illness and physical disability, but this material has never been collected in one place.

G Serratrice Les organisateurs de ce symposium en ont choisi le titre: " Syndrome de fatigue chronique ", titre dont chacun des termes doit etre defini avec precision, ce qui, paradoxalement, n'est pas aise. Syndrome: ensemble de symptomes ou de signes s'observant dans des etats pathologiques differents mais ne determinant pas a eux seuls la cause de la maladie. Fatigue: symptome plus ou moins exprime, moteur, intellectuel, sensoriel, sexuel selon les cas. Mais aussi signe traduit par l'incapacite a maintenir une force initiale pendant un effort continu. Ceci separe la fatigue de la faiblesse, qui est l'incapacite a produire une force. Stricto sensu, l'asthenie et la fai- blesse sont equivalentes. Mais l'usage, tout au moins en France, fait souvent confondre asthenie et fatigue. Chronique enfin. C'est sans doute sur cet adjectif que s'accumulent les plus grandes ambiguites. La simple lecture du programme d'aujour- d'hui indique la difficulte de se situer entre une definition stricte - chronique signi- fiant " permanent ", " qui dure " - et l'usage, surtout dans l'acception anglo-ameri- caine, qui reserve l'appellation de chronique a une forme particuliere de fatigue, parfois dite post-virale. En fait, il convient, pour une claire comprehension, de sepa- rer ce que l'on pourrait nommer les etats de fatigue chronique " determines " dans leur mecanisme et ceux qui restent " indetermines ". A l'evidence, les etats dont le mecanisme est determine sont tres diversifies.

Francois Delaporte's Chagas Disease chronicles Brazilian medicine's encounter with a disease, an insect, and a history of discovery. Between 1909 and 1911, Carlos Chagas described an infection (pathogenic trypanosome), its intermediate host, and the illness that he believed it caused, parasitic thyroiditis. Chagas's work did not lack significance: the disease that came to share his name would be one of Latin America's most serious endemic diseases. However, the clinical identification of the disease through "Romana's sign" (a palpebral edema or swelling of the eyelid) some decades later marked a transformation in the general medical knowledge of the disease and its basis altogether. Not only was the disease entity that Chagas had described shown to be a nosological illusion, but twenty-five years of scientific controversy turned out to have been based on a misunderstanding. The continued use of the term "Chagas's Disease" even after Cecilio Romana's discovery thus refers to a fundamental ambiguity. Delaporte dispels this ambiguity by re-examining the various discoveries, dead ends, controversies, and major epistemological transformations that marked the history of the disease--a history that begins with the creation of the Oswaldo Cruz Institute in Rio de Janeiro and ends in the forests of Santa Fe in northern Argentina. Delaporte's study shows how an epistemological focus can add depth to the history of medicine and complexity to accounts of scientific discovery.

Sir Francis Avery Jones 149 Harley Street, London, WlN 2DE, U.K. This first international symposium on Mucus in Health and Disease brought together medical scientists, physiologists, pharmacologists, physicians, surgeons, gynaecologists, ophthalmologists, anatomists, biologists, medical engineers and biochemists - a spectrum which indicates the wide field of interest in mucus both in health and in disease. The idea for the meeting came from Dr. S. Gottfried whose researches led to the development of carbenoxolone, a substance which stimulates mucus production and in this way favours the healing of peptic ulcers. The idea was enthusiastically welcomed by Professor Dennis Parke and he, and Mr. Max Elstein, have been the dynamo behind the meeting. The opening keynote address by Professor Clamp set the scene for the Symposium, painting a broad canvas and highlighting the main features. We cannot do without mucus, irritating though it may be if there is too much or too little, and in so many systems of the body it plays a vital role. For the first time the specialists in different systems of the body have had the opportunity of coming together and discussing their special problems - a cross-fertilisation which proved to be most valuable, not only for one another but also for the medical scientists who had been closely concerned with the chemistry and physical properties of mucus.