The past few years have witnessed rapid progress in the characterization of mechanisms that underlie the generation and processing of inter- and intracellular signals. While there have been significant corollary advances in the area of signaling in disease processes, there is as yet no single resource that connects these advances with an understanding of disease processes and applications for novel therapeutics. Collecting chapters from the leading experts in their respective fields, editors Toren Finkel and Silvio Gutkind deliver a much-needed introduction to signaling and a fruitful discussion of promising directions for future research.

Signal Transduction and Human Disease capitalizes on the current emphasis on translational research and biological relevance in biotechnology and, conversely, the importance of molecular approaches for clinical research. Each chapter conveys the sense of a disease process, what it affects, how it presents, how common it is, and what the treatments are. Clinical descriptions are not exhaustive but rather serve as an outline regarding the disease’s manifestations and current treatment options. Following this introduction, the authors present an in-depth discussion of one or two signal transduction pathways or biological processes relevant to the disease. The editors divide their study into five sections:

• Cardio-Pulmonary Disease
• Oncology
• Endocrinology
• Infectious Disease
• Allergy/Rheumatology
• Neurology/Psychiatry

Biochemists, molecular and cell biologists, immunologists, pharmacologists, and clinical researchers, as well as graduate students in a variety of scientific disciplines, will find Signal Transduction and Human Disease to be an invaluable addition to the literature.

Is lowering your temperature when you have a fever helpful? Do you really need to finish every course of antibiotics? Or could some of the treatments you think are healing you actually be harming you? Medicine has significantly advanced in the last few decades. But while we have learned a lot, we still rely on medical interventions that are vastly out of date and can adversely affect our health. In this game-changing book, infectious-disease expert and Rotavirus vaccine inventor Dr Offit highlights fifteen common medical interventions still recommended and practised by medical professionals, despite clear evidence that they are harmful - including the treatment of acid reflux in babies and the reliance on heart stents and knee surgery. By presenting medical alternatives, Overkill gives patients invaluable information to help them ask their doctors better questions and to advocate for their own health.

** With a new introduction by Russell T Davies ** A new edition of the award-winning, ground-breaking account of the early AIDS crisis in Britain. 'A remarkable journalistic achievement.' Time Out 'Powerful . . . Indispensable.' Observer 'Superb.' London Review of Books Winner of the Somerset Maugham Prize How does a country control a virus that is killing increasing numbers of people? How does a government contain an epidemic spread by sex, drug use and blood products? And how does a population react when told that everyone is at risk from infection? By 1986, when the British Government woke up to the problem of AIDS, it estimated that 30,000 people had already been infected with HIV. Why was it so slow to act? Would the situation have been different if most of those affected had not been gay men? Award-winning journalist Simon Garfield presents a story of political intrigue, of panic and hysteria, of wasted opportunities and of a medical battle conducted against seemingly impossible odds. Including interviews with key figures in the fight against the virus as well as those facing personal devastation and prejudice, The End of Innocence is an important and powerful story, compellingly told. Features a new afterword by the author.

Research into the role of diet in chronic disease can be difficult to interpret. Measurement errors in different studies often produce conflicting answers to the same questions. Seventh-day Adventists and other groups with many vegetarian members are ideal study populations because they have a wide range of dietary habits that adds power and clarity to research findings.

This book analyses the results of such studies, focusing on heart disease and cancer. These studies support the benefits of a vegetarian diet and in addition provide evidence about the effects of individual foods and food groups on disease risk that is relevant to all who are interested in good health. The author places the findings in the broader context of well-designed nutritional studies of the general population. He discusses the degree of confidence we can have in particular relationships between diet and disease based on the strength of the evidence. The book is written in a clear style with an extensive glossary, and should be accessible to a wide audience.

Key Points: 1. Discusses the role of microbial enzymes in functional food and nutraceutical production 2. Covers a range of enzymes like proteases, pullulanases, lipases 3. Explores various microbial sourcess and processing techniques 4. Reviews application of enzymes in synthesis of chiral drug intermediates 5. Examines molecular techniques on improving microbial enzymes properties and ability

Addressing a major field of interest for oncologists, cell biologists, and other biomedical researchers, Beyond Apoptosis provides an overview of how different biological mechanisms of cell death, senescence and mitotic catastrophe stop the growth of tumor cells treated with anticancer agents.

Written by internationally renowned contributors, this text includes:

• morphological illustrations, as well as a DVD containing documents and video clips from various time-lapse microscopic studies of cell death and mitotic catastrophe
• the role and limitations of apoptosis as a determinant of the toxicity of anticancer agents
• alternative mechanisms of the antiproliferative actions of anticancer drugs and radiation, such as non-apoptotic cell death, cell senescence, and mitotic catastrophe
• non-apoptotic forms of cell death, such as necrosis, paraptosis, autophagic cell death, and others
• morphological and kinetic differences of the various forms of cell death

Showcasing the expertise of top-tier specialists who contributed to the newly released guidelines for the care of thrombosis in cancer patients, this exciting guide was written and edited by members of the American Society of Clinical Oncology panel, (ASCO), on the prevention and treatment of cancer-associated thrombosis, among others, and provides an authoritative discussion of strategies to effectively implement and interpret the new ASCO/NCCN directives. Standing as the only up-to-date source to readily examine exciting new translational science findings regarding the biology of cancer-associated thrombosis, as well as new clinical recommendations, this guide supplies an authoritative and current discussion of the mechanisms, management, and prevention of cancer-associated thrombosis.

about the book... Assisting clinicians in the differential diagnosis of the wide range of disorders responsible for fever of unknown origin (FUO), this source stands as the only recent and comprehensive differential diagnosis of these conditions. This guide provides a clear overview of diagnostic approaches and offers expert recommendations that are invaluable to anyone caring for patients with prolonged undiagnosed fever. Written by clinicians for clinicians, this single authoritative source emphasizes the syndromic approach in the diagnosis of FUOs...discusses the etiology and distribution of disorders causing FUOs...and stresses the importance of a focused history, physical examination, and laboratory tests in the differential diagnosis of the FUO patient. about the editor... BURKE A. CUNHA is Chief, Infectious Disease Division, Winthrop-University Hospital, Mineola, New York, and Professor of Medicine, State University of New York School of Medicine, Stony Brook. Dr. Cunha is the author or coauthor of more than 150 abstracts, 100 electronic publications, 1000 articles, and 150 book chapters. He has edited 20 books on various infectious disease topics and is Editor-in-Chief of the journals Infectious Disease Practice and Antibiotics for Clinicians. Dr. Cunha is a Fellow of the Infectious Diseases Society of America. Dr. Cunha is internationally recognized as a teacher-clinician and is the recipient of many teaching awards including the prestigious Aesculapius Award. Dr. Cunha is a Master the American College of Physicians awarded for lifetime achievement as a master clinician and teacher of infectious diseases. Dr. Cunha received the M.D. degree from Pennsylvania State UniversityCollege of Medicine, Hershey.

An intensive-care doctor reveals the long-term problems caused by ICUs, and how these can be prevented. Thousands of people are admitted to intensive-care units (ICUs) every day, and this is only increasing with the Covid-19 pandemic. Most of these admissions will be sudden, unexpected, and harrowing - an experience that can alter patients and their families in physical, emotional, and spiritual ways, with effects that endure for years. But there is hope. Dr Ely is a leading ICU doctor. His unconventional methods minimise patients being harmed by the cutting-edge technologies that are saving their lives; post-intensive care syndrome (PICS) is a well-established complication that millions of ICU survivors battle, which Dr Ely aims to eradicate. His cutting-edge studies have convinced doctors around the world to change their ICU practices for the better. Through captivating stories, Dr Ely shows how he and colleagues from around the world have re-introduced humanity into the ICU, creating pathways that bring hope and healing to healthcare. This is the future of medicine, and is a must-read for healthcare professionals, patients, and their families.

Patients with mental and substance use disorders have shown higher rates of morbidity and mortality from medical illnesses than the general population, and physicians are also increasingly aware of adverse effects of psychiatric medications on metabolic and cardiovascular health. In light of these problems, this book addresses an important unmet need of patients with mental disorders -- namely, the lack of integration of general medical care with psychiatric care and the related problem of barriers to collaboration and communication among health care providers. Managing Metabolic Abnormalities in the Psychiatrically Ill is the first book to provide a current review of the relationships among psychiatric illnesses, metabolic abnormalities, and treatment, focusing on how clinicians can tailor care to those doubly-afflicted patients.

The book integrates research findings into practical clinical guidelines that spell out what psychiatrists need to know when their patients with mental illness suffer from -- or are at risk of developing -- obesity, diabetes, cardiovascular disease, or the metabolic syndrome. The contributors address those risks that need to be considered in the overall context of treatment, background risks of medical illnesses associated with specific psychiatric disorders themselves, and the means of applying these data to treatment recommendations, monitoring, and clinical practice. Among the specific topics addressed are: - Potential effects of psychotropics on appetite, body weight, and metabolic parameters in obese patients, and the potential effects of anti-obesity agents on psychotic, manic, and depressive syndromes- Increased risk of type 2 diabetes among individuals with psychotic and mood disorders due to neurobiological changes and behavioral effects associated with these disorders- Greater risk for cardiovascular disease among the mentally ill, stressing the importance of mental health providers understanding cardiovascular risk classification and modification strategies- An association between dysregulation of glucose and lipid metabolism and the related risk of type 2 diabetes during treatment with any of the eight second-generation antipsychotics currently available in the United States- Guidance in choice of medications and appropriate monitoring strategies for hyperlipidemia, along with recognition of which antipsychotics pose the greatest risk and an understanding of the common dyslipidemia patterns seen with their use

Chapters include key clinical concepts, quick-reference tables, and extensive references, and a final chapter provides an assessment tool for evaluating patients' metabolic risk. Together, the chapters in this book constitute an authoritative clinical guide that enables psychiatrists to better integrate the treatment of patients' mental disorders with their metabolic conditions.

About the book: Standing alone as the first definitive and comprehensive book on the subject, this guide describes the most recent studies on the brain-gut connection and psychosocial issues related to patients experiencing visceral pain. Bringing together leading experts from the top-tiers of the science, this source provides 33 engaging chapters and spans basic concepts in pharmacology, neurobiology, physiology, and psychology to provide a practical approach to the treatment of chronic pain. Examining a condition that affects up to 25% of the general U.S. population, this source is the only book on the subject to cover both clinical syndromes and neurobiology and ranges from basic mechanisms to diagnosis and clinical treatment of specific syndromes including inflammatory bowel disease, functional abdominal pain, dyspepsia, non-cardiac chest pain, and pelvic pain syndromes; analyses the latest scientific advances including the role of functional imaging in patient care; integrates fundamental scientific concepts with a practical clinical approach; and; supplies 250 figures, and more than 16 color photographs. About the editors: P.Jay Pasricha is Chief, Division of Gastroenterology research that includes pain and motility disorders. Dr. Pasricha has served on numerous national gastroenterological committees and on NIH panels. He holds several patents related to gastrointestinal diagnostics and therapeutics and is a consultant to many companies. He received the M.D. degree (1982) from the All-India Institute of Medical Sciences, New Delhi. William D. Willis is Director, Cecil H. and Ida M. Green Chair, and Chief of the Division of Comparative Neurobiology, Marine Biomedical Institute; Professor and Chairman, Department of Anatomy & Neurosciences; and Professor, Department of Physiology & Biophysics; University of Texas Medical Branch, Galveston. Dr.Willis has been President of the Society for Neuroscience (1984-1985), the Association of Neuroscience Departments and Programs (1982-1983), and the American Pain Society (1982-1983). He has also been on the Executive Committee of the American Association of Anatomists (1982-1986) and the Council of the International Association for the Study of Pain (1984-1990). He received the M.D. degree (196) from the University of Texas Southwestern Medi Gebghart is Head, Department of Pharmacology, University of Iowa, Iowa City. The author or editor of numerous professional publications, he is editor-in-chief of the Journal of Pain and is the recipient of the Purdue Pharma Prize for Pain Research (2004).

What causes chronic and persistent fatigue in so many people? How is it best prevented and treated? What can patients and physicians do to better understand this common medical issue? Fatigue is an extremely common component of many physical and mental disorders, from anxiety and depression to heart disease and hypertension. Many patients even find themselves suffering from persistent fatigue with little understanding of how to safely and effectively treat the issue, especially if their symptoms don’t qualify for diagnosis as Chronic Fatigue Syndrome, which can make them “fall through the cracks� of the medical system.   But now, with Fatigue and Dysautonomia: Chronic or Persistent, What’s the Difference?, physicians Joseph Colombo and Nicholas L. DePace aim to close those cracks, offering a simplified analysis and discussion focusing on this common patient complaint and how best to treat it. Topics covered include: ​ Parasympathetic and Sympathetic (P&S) causes of both chronic and “persistent� fatigue Natural therapies to help relieve fatigue and promote wellness.  Concepts of fatigue, the six-pronged Mind-Body Wellness Program, and the P&S nervous systems.  Causal relationships between fatigue and P&S dysfunction (a more specific description of autonomic dysfunction or dysautonomia) How to treat fatigue with supplements and lifestyle modifications that have been documented to work without the added side-effects of most pharmaceutical therapies.  Presenting discussions with patients and doctors side-by-side to help physicians see how to present information to their patients and patients to learn what physicians need to know to tailor therapy to their individual needs, Fatigue and Dysautonomia is an essential resource for anyone concerned with fatigue, from medical professionals to patients to family and friends.

Providing a detailed coverage that is impossible in broader-based textbooks, "Urogenital Ultrasound, Second Edition", is a comprehensive study of genitourinary ultrasound that has been completely revised to keep up-to-date with this rapidly changing field. Reflecting the obviously visual nature of ultrasound imaging, "Urogenital Ultrasound, Second Edition" contains more than 1,000 images, including those from more technically advanced ultrasound machines than were in the first edition. Aiding the reader in recognizing various disease states and recommending effective therapeutic or surgical measures, this new edition also covers all recent developments, explained in a pragmatic style that is easily read and understood.

This reference is the most current and comprehensive source on the many aspects of sarcoidosis, covering topics ranging from the basic science and pathophysiology of the disease to patient evaluation and treatment. It provides a detailed analysis of the pulmonary aspects of the condition and includes chapters on radiographic manifestations, bronchoalveolar lavage research, pulmonary function studies, and proposed markers for the diagnosis and management of the disease.

A detailed compilation of the latest research and recommendations for the diagnosis and assessment of esophageal disorders, this reference delves into a wide range of applications and technologies currently utilized in the field including radiology, endoscopy, endoscopic ultrasonography, manometry, ambulatory manometry, pH testing, catheter-free pH testing, bilitec monitoring, and impedance plethysmography.

The Understanding GERD chart presents a detailed overview of the symptoms and causes of Gastroesophageal Reflux Disease (GERD). Several views show normal esophagus and stomach anatomy, as well as GERD, esophagitis and Barrett's esophagus. Heavy gauge 3ml lamination with sealed edges and two metal eyelets for hanging makes chart highly durable. Write-on/wipe-off with dry erase marker (not included).

This book summarizes the most current research on the anemia of chronic disease and identifies effective diagnostic strategies for this common clinical condition-covering key topics related to the design and selection of therapeutic options including the treatment of the underlying disease, the biology of erythropoietin and the regulation of erythropoiesis, the disturbance of iron homeostasis, and the complex nature of the systemic inflammatory response.